CN110269814A - A kind of preparation method of the crease-resistant composite skin care product containing Argireline - Google Patents
A kind of preparation method of the crease-resistant composite skin care product containing Argireline Download PDFInfo
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- CN110269814A CN110269814A CN201910209573.8A CN201910209573A CN110269814A CN 110269814 A CN110269814 A CN 110269814A CN 201910209573 A CN201910209573 A CN 201910209573A CN 110269814 A CN110269814 A CN 110269814A
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- argireline
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- crease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
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- Cosmetics (AREA)
Abstract
A kind of preparation method of the crease-resistant composite skin care product containing Argireline of the disclosure of the invention of this composite skin care product preparation technical field, should crease-resistant composite skin care product containing Argireline by component ratio include: Argireline: 0.5-6 parts；Sodium Hyaluronate: 0.1-0.5 parts；- 5:0.5-2 parts of palmityl tripeptides；Butanediol: 2 parts；[water, oligopeptides -1, dipotassium hydrogen phosphate, sodium chloride, glycerol]: 0.5 part；Water: 90 parts；Arginine: 0.1 part；Argireline of the present invention can be affected in such a way that percutaneous drug delivery penetrates because of personal metabolic rate and dosage frequency; so to reach crease-resistant personal nursing effect; it needs to be nursed for static wrinkle with dynamic expression line; the present invention can improve the permeability of Argireline and the reparation of static wrinkle; and present invention can apply to the facial mask essence in skin care item, Essence, lotions; the addition of maintenance skin effect object of cream, and protect product stability.
Description
Technical field
The present invention relates to skin care field more particularly to a kind of crease-resistant composite skin care products containing Argireline
Preparation method.
Background technique
Skin care item are many kinds of on the market at present, and effect is different, including whitening, moisturizing, nti-freckle and anti-aging etc..But it is very much
Product is more or less added to some chemical substances being harmful to the human body, although these substances have short-term beauty to the skin of people
The skin care effects such as white, anti-aging can make skin severely damaged, long acne, color spot and oil occur instead but if being used for a long time
Rouge dyssecretosis etc.；Argireline is commonly called as Argireline between imitative, is the N-terminal analogies of SNAP-25, can be with SNARE
Originally existed protein s NAP-25 competitive position in compound, any ingredient without destroying compound can destroy it
The stability of formation, when SNARE compound becomes slightly unstable, vesica cannot be released effectively neurotransmitter, as a result, flesh
Meat becomes relaxation but does not generate paralysis, and microgroove and wrinkle are formed and reduced, and is declared with this to reach crease-resistant, but use second merely
Acyl group hexapeptide -8 can be affected in such a way that percutaneous drug delivery penetrates because of personal metabolic rate and dosage frequency, therefore, we
Propose a kind of preparation method of crease-resistant composite skin care product containing Argireline.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, and the one kind proposed contains acetyl group six
The preparation method of the crease-resistant composite skin care product of peptide -8.
To achieve the goals above, present invention employs following technical solutions: a kind of to contain the crease-resistant of Argireline
The preparation method of composite skin care product, being somebody's turn to do the crease-resistant composite skin care product containing Argireline by component ratio includes:
Preferably, a kind of preparation of the crease-resistant composite skin care product containing Argireline as described in claim 1
Method, the preparation method for being somebody's turn to do the crease-resistant composite skin care product containing Argireline include the following steps:
S1: raw material screening: by the component of compositing formula in claim 1 than being equipped with raw material: Argireline:
0.5-6 parts；Sodium Hyaluronate: 0.1-0.5 parts；- 5:0.5-2 parts of palmityl tripeptides；Butanediol: 2 parts；[water, oligopeptides -1, phosphoric acid
Hydrogen dipotassium, sodium chloride, glycerol]: 0.5 part；Water: 90 parts；Arginine: 0.1 part；
S2: stir for the first time: by Sodium Hyaluronate: 0.1-0.5 parts and water: 90 parts are sufficiently mixed in ultrasonic oscillator
Uniformly after be heated to 70 DEG C, then pour the mixture into homogeneous 3min in homogenizer, after be cooled to 40 DEG C, it is spare to obtain mixture；
S3: second stirs: by Argireline: 0.5-6 parts；- 5:0.5-2 parts of palmityl tripeptides；Butanediol: 2
Part；Arginine: 0.1 part is put into the resulting mixture of above-mentioned steps S1, is stirred in ultrasonic oscillator, is adjusted
PH to 6.5 is saved, continuously add [water, oligopeptides -1, dipotassium hydrogen phosphate, sodium chloride, glycerol]: 0.5 part stirs, and 20 DEG C quiet
It sets 16h and obtains composition finished product.
Preferably, Argireline used in described composition uses Lipotec ARGIRELINE, thoroughly
Bright matter acid sodium uses Roelmihpc Cube3, and palmityl tripeptides -5 use DSM Syn-Coll, [water, oligopeptides -1,
Dipotassium hydrogen phosphate, sodium chloride, glycerol] use the transdermal small peptide of Long Sheng biotechnology company.
Preferably, the cooling in the step S2 is natural cooling.
Preferably, homogenizer model RX-200l in the step S2.
A kind of preparation method of crease-resistant composite skin care product containing Argireline provided by the invention, acetyl group six
Peptide -8 can be affected in such a way that percutaneous drug delivery penetrates because of personal metabolic rate and dosage frequency, so to reach crease-resistant
Personal nursing effect needs to be nursed for static wrinkle with dynamic expression line, and the present invention can improve acetyl group hexapeptide-
The reparation of 8 permeability and static wrinkle, and present invention can apply to the facial mask essence in skin care item, Essence, creams
Liquid, the addition of maintenance skin effect object of cream, and protect product stability.
Detailed description of the invention
Fig. 1 is preparation flow figure of the present invention；
Fig. 2 is that the present invention lifts crease-resistant effect comparison diagram；
Fig. 3 is water-soluble material test comparison chart of the present invention；
Fig. 4 is percutaneous absorbtion increase rate comparison diagram of the present invention；
Fig. 5 is the present inventor's weight structure epidermis transdermal penetration experimental comparison figure.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, below in conjunction with specific embodiment, to this
Invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, not
For limiting the present invention.
A kind of preparation method of the crease-resistant composite skin care product containing Argireline should contain Argireline
Crease-resistant composite skin care product includes: by component ratio
The preparation method of the crease-resistant composite skin care product for containing Argireline includes the following steps:
S1: raw material screening: by the component of compositing formula in claim 1 than being equipped with raw material: Argireline:
0.5-6 parts；Sodium Hyaluronate: 0.1-0.5 parts；- 5:0.5-2 parts of palmityl tripeptides；Butanediol: 2 parts；[water, oligopeptides -1, phosphoric acid
Hydrogen dipotassium, sodium chloride, glycerol]: 0.5 part；Water: 90 parts；Arginine: 0.1 part；
S2: stir for the first time: by Sodium Hyaluronate: 0.1-0.5 parts and water: 90 parts are sufficiently mixed in ultrasonic oscillator
Uniformly after be heated to 70 DEG C, then pour the mixture into homogeneous 3min in homogenizer, after be cooled to 40 DEG C, it is spare to obtain mixture；
S3: second stirs: by Argireline: 0.5-6 parts；- 5:0.5-2 parts of palmityl tripeptides；Butanediol: 2
Part；Arginine: 0.1 part is put into the resulting mixture of above-mentioned steps S1, is stirred in ultrasonic oscillator, is adjusted
PH to 6.5 is saved, continuously add [water, oligopeptides -1, dipotassium hydrogen phosphate, sodium chloride, glycerol]: 0.5 part stirs, and 20 DEG C quiet
It sets 16h and obtains composition finished product.
Wherein, Argireline used in described composition uses Lipotec ARGIRELINE, transparent
Matter acid sodium uses Roelmihpc Cube3, and palmityl tripeptides -5 use DSM Syn-Coll, [water, oligopeptides -1, phosphorus
Sour hydrogen dipotassium, sodium chloride, glycerol] use the transdermal small peptide of Long Sheng biotechnology company；Cooling in the step S2 is
Natural cooling；Homogenizer model RX-200l in the step S2.
Fig. 2-5, we have done an experiment, improve water soluble ingredient by the percutaneous absorbtion rate of Cube3 and utilize CD44
The reciprocation of receptor and transdermal peptide promote the Percutaneously absorbable of this skin care compositions, then cooperate Argireline
Reach the effect of crease-resistant.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (5)
1. a kind of preparation method of the crease-resistant composite skin care product containing Argireline, it is characterised in that: this contains acetyl
The crease-resistant composite skin care product of base hexapeptide -8 includes: by component ratio
2. a kind of preparation method of the crease-resistant composite skin care product containing Argireline as described in claim 1, special
Sign is: the preparation method for being somebody's turn to do the crease-resistant composite skin care product containing Argireline includes the following steps:
S1: raw material screening: by the component of compositing formula in claim 1 than being equipped with raw material: Argireline: 0.5-6
Part；Sodium Hyaluronate: 0.1-0.5 parts；- 5:0.5-2 parts of palmityl tripeptides；Butanediol: 2 parts；[water, oligopeptides -1, phosphoric acid hydrogen two
Potassium, sodium chloride, glycerol]: 0.5 part；Water: 90 parts；Arginine: 0.1 part；
S2: stir for the first time: by Sodium Hyaluronate: 0.1-0.5 part and water: 90 parts be sufficiently mixed in ultrasonic oscillator it is uniform
After be heated to 70 DEG C, then pour the mixture into homogeneous 3min in homogenizer, after be cooled to 40 DEG C, it is spare to obtain mixture；
S3: second stirs: by Argireline: 0.5-6 parts；- 5:0.5-2 parts of palmityl tripeptides；Butanediol: 2 parts；Smart ammonia
Acid: 0.1 part is put into the resulting mixture of above-mentioned steps S1, is stirred in ultrasonic oscillator, adjust pH to
6.5, continuously add [water, oligopeptides -1, dipotassium hydrogen phosphate, sodium chloride, glycerol]: 0.5 part stirs, 20 DEG C of standing 16h
Obtain composition finished product.
3. a kind of preparation method of crease-resistant composite skin care product containing Argireline according to claim 1 or 2,
It is characterized by: Argireline used in described composition uses Lipotec ARGIRELINE, hyalomitome
Sour sodium uses Roelmihpc Cube3, and palmityl tripeptides -5 use DSM Syn-Coll, [water, oligopeptides -1, phosphoric acid
Hydrogen dipotassium, sodium chloride, glycerol] use the transdermal small peptide of Long Sheng biotechnology company.
4. a kind of preparation method of crease-resistant composite skin care product containing Argireline according to claim 2,
Be characterized in that: the cooling in the step S2 is natural cooling.
5. a kind of preparation method of crease-resistant composite skin care product containing Argireline according to claim 2,
It is characterized in that: homogenizer model RX-200l in the step S2.
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| CN201910209573.8A CN110269814A (en) | 2019-03-19 | 2019-03-19 | A kind of preparation method of the crease-resistant composite skin care product containing Argireline |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110604711A (en) * | 2019-10-17 | 2019-12-24 | 广州市玉鑫化妆品有限公司 | Multi-effect eye mask and preparation method thereof |
| CN110613654A (en) * | 2019-11-04 | 2019-12-27 | 菲朗生物科技(湖北)有限公司 | Polypeptide compact mask liquid and preparation method thereof |
| CN110721144A (en) * | 2019-11-27 | 2020-01-24 | 广州元美盛化妆品有限公司 | Preservative-free anti-wrinkle mask and preparation method thereof |
| CN111557884A (en) * | 2020-05-29 | 2020-08-21 | 广州韩逆素生物科技有限公司 | Skin-refreshing and beautifying skin-penetrating liquid and preparation method thereof |
| CN112472638A (en) * | 2019-10-10 | 2021-03-12 | 广东丸美生物技术股份有限公司 | Anti-aging matrix and preparation method and application thereof |
| CN113679628A (en) * | 2021-09-02 | 2021-11-23 | 广州睿森生物科技有限公司 | Skin care composition for comprehensively improving skin problems and application thereof |
| CN115177636A (en) * | 2022-07-18 | 2022-10-14 | 陕西科美致尚生物科技有限公司 | Composition for treating prostate calcification and preparation method and application thereof |
| CN115400043A (en) * | 2022-08-04 | 2022-11-29 | 广州环亚化妆品科技股份有限公司 | Anti-wrinkle composition, preparation method thereof and application thereof in cosmetics |
| CN115737472A (en) * | 2022-12-01 | 2023-03-07 | 河北纳科生物科技有限公司 | Composition containing recombinant collagen and capable of immediately relieving expression wrinkles and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106726673A (en) * | 2017-02-28 | 2017-05-31 | 广州诚予化妆品有限公司 | A kind of humidity-preserving type has the stoste formula and its technique for repairing crease-resistant function |
| CN108703894A (en) * | 2018-08-21 | 2018-10-26 | 广东博然堂生物科技有限公司 | It is a kind of that there is whitening, anti-ageing complex polypeptide composition and preparation method thereof |
-
2019
- 2019-03-19 CN CN201910209573.8A patent/CN110269814A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106726673A (en) * | 2017-02-28 | 2017-05-31 | 广州诚予化妆品有限公司 | A kind of humidity-preserving type has the stoste formula and its technique for repairing crease-resistant function |
| CN108703894A (en) * | 2018-08-21 | 2018-10-26 | 广东博然堂生物科技有限公司 | It is a kind of that there is whitening, anti-ageing complex polypeptide composition and preparation method thereof |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112472638A (en) * | 2019-10-10 | 2021-03-12 | 广东丸美生物技术股份有限公司 | Anti-aging matrix and preparation method and application thereof |
| CN112472638B (en) * | 2019-10-10 | 2022-05-31 | 广东丸美生物技术股份有限公司 | Anti-aging matrix and preparation method and application thereof |
| CN110604711A (en) * | 2019-10-17 | 2019-12-24 | 广州市玉鑫化妆品有限公司 | Multi-effect eye mask and preparation method thereof |
| CN110613654A (en) * | 2019-11-04 | 2019-12-27 | 菲朗生物科技(湖北)有限公司 | Polypeptide compact mask liquid and preparation method thereof |
| CN110721144A (en) * | 2019-11-27 | 2020-01-24 | 广州元美盛化妆品有限公司 | Preservative-free anti-wrinkle mask and preparation method thereof |
| CN111557884A (en) * | 2020-05-29 | 2020-08-21 | 广州韩逆素生物科技有限公司 | Skin-refreshing and beautifying skin-penetrating liquid and preparation method thereof |
| CN113679628A (en) * | 2021-09-02 | 2021-11-23 | 广州睿森生物科技有限公司 | Skin care composition for comprehensively improving skin problems and application thereof |
| CN115177636A (en) * | 2022-07-18 | 2022-10-14 | 陕西科美致尚生物科技有限公司 | Composition for treating prostate calcification and preparation method and application thereof |
| CN115400043A (en) * | 2022-08-04 | 2022-11-29 | 广州环亚化妆品科技股份有限公司 | Anti-wrinkle composition, preparation method thereof and application thereof in cosmetics |
| CN115400043B (en) * | 2022-08-04 | 2023-10-31 | 广州环亚化妆品科技股份有限公司 | Anti-wrinkle composition, preparation method thereof and application thereof in cosmetics |
| CN115737472A (en) * | 2022-12-01 | 2023-03-07 | 河北纳科生物科技有限公司 | Composition containing recombinant collagen and capable of immediately relieving expression wrinkles and preparation method thereof |
| CN115737472B (en) * | 2022-12-01 | 2024-01-02 | 河北纳科生物科技有限公司 | Composition containing recombinant collagen and capable of immediately relieving expression lines and preparation method thereof |
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Application publication date: 20190924 |
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