RU2622020C1 - Complex cosmetic composition for the skin treatment - Google Patents

Abstract

FIELD: cosmetology.

SUBSTANCE: invention represents cosmetic composition for the skin treatment that involves a colloidal nanogold, a dimethylaminoethanol, a colloidal nanosilver, a ergothioneine, a arginine and additive components where the additive components correspond to the emollients, and/or ultraviolet-light filters, and/or moisturizers, and/or emulsifying agents, and/or co-emulsifying agents, and/or structure-forming agents, and/or preservation agents, and/or enhancer, and/or anti-oxidizing agents, and/or pH-adjusting agents, and/or rejuvenescent components, and/or gelatinization agents, and/or recovering components, and/or complexing compound, and/or active substance, and/or prebiotic, and/or decomposers where the components in the composition correlate with each other in wt %.

EFFECT: obtention of the hypoallergic beauty product with a supple and delicate texture, rejuvenating effect and a barrier action.

8 cl, 7 tbl, 3 ex

Description

The invention relates to cosmetology, in particular to the creation of a comprehensive cosmetic product based on a cosmetic composition containing colloidal nanogold and colloidal nanosilver, for skin care with anti-aging, protective, anti-inflammatory effect and lifting effect, in addition, the complex cosmetic product has a delicate texture and quickly absorbed without residue.

Consumers need cosmetics for skin care that are easily and quickly applied to the skin in the form of a layer that should not be thick, easily absorbed without residue and do not create the effect of oily skin, as well as anti-aging skin products.

Such products typically contain active ingredients with anti-aging activity and colored particles, such as pigments or nacre, to mask signs of aging.

Hyaluronic acid-based products described in patent sources of the Russian Federation 2078561, RF 2438648, as well as products based on a composition consisting of hyaluronic acid and colloidal silver (RF patent 2514003) can be named among complex anti-aging cosmetics. Alpha hydroxy acids such as lactic acid and citric acid, beta hydroxy acids such as salicylic acid, as well as jasmonic acid derivatives, in particular those described in EP 1333021, may be mentioned among anti-aging skin active ingredients.

However, hyaluronic acid obtained by a biotechnological method inevitably contains toxins, since it is produced by microorganisms pathogenic to the human body (staphylococci), which significantly reduces the biological activity of these agents.

Jasmonic acid derivatives have the advantage of being well tolerated and not causing skin discomfort, such as tingling, tightness or redness. However, the introduction of such compounds into cosmetic formulations, in particular in the form of emulsions, can significantly alter stability and cause phase reversal.

The closest technical solution to the problem is the cream "Sensai" manufacturer Kanebo (Japan), which has a complex cosmetic effect. However, the product creates the effect of oiliness of the skin, there is no protection against ultraviolet radiation, it has a strong fragrance, which can cause an allergic reaction.

Thus, there is a need for cosmetics that are hypoallergenic and have good properties for cosmetic use.

The technical result of the present invention is the creation of a hypoallergenic cosmetic product for the care of aging skin with a soft and delicate texture, with a rejuvenating effect and a protective effect.

The technical result is achieved by creating a cosmetic composition in the following ratio of components (%):

colloidal nanogold 1-10 dimethylaminoethanol 1-5 colloidal nanosilver 0.1-5 ergotionein 0.01-1 arginine 0.01-1 additional components rest

In another embodiment, the invention relates to the use of a cosmetic composition for the preparation of a comprehensive cosmetic skin care product.

In another embodiment, the invention relates to a comprehensive cosmetic skin care product containing a cosmetic composition in which the additional components are represented by an emollient in an amount of 0.01-35% and / or an ultraviolet filter of 3-25%, and / or a moisturizer is 0 , 1-10%, and / or emulsifier - 5-25%, and / or co-emulsifier - 2-10%, and / or structure-forming agent - 0.5-10%, and / or preservative - 0.2-2 %, and / or enhancer - 0.1-0.5%, and / or antioxidant - 0.2-1%, and / or acidity regulator - 0.1-0.5%, and / or anti-aging component - 0 , 1-25%, and / or gel by a carrier agent - 0.2-2%, and / or a regenerating component - 0.5-3%, and / or a complexing agent - 0.1-0.5%, and / or an active substance - 0.1-0.5% , and / or prebiotic - 0.1-0.5%, and with a solvent up to 100%.

In a preferred embodiment, the invention relates to a complex cosmetic product in which the emollient is represented by at least one substance selected from the group: ethylhexyl palmitate, hydrogenated polydecene, dimethicone, olive squalene, apricot oil, Rosa Canina fruit oil, isopropyl myristate, isononyl isononanoate, g oil cetyl palmitate, tertylhexanoin, phytosterols, macadamia nut oil, cholesteryl stearate, dimethicone / vinyl demiconcrosspolymer, avocado oil. The ultraviolet filter is represented by at least one substance selected from the group: ethylhexylmethoxycinnamate, cetylethylhexanoate, benzophenone-3, ethylhexyltriazone, a humectant is represented by at least one substance selected from the group: glycerin, hydrolyzed soy protein, hydrolyzed sodium hydroxide, vegetable protein Centaurea Cyanus, Ampelopsis grossedentata extract, sodium DND, Moms Alba root extract, Paeonia Albiflora root extract, Aloe Ferox leaf extract, Sophora Angustifolia root extract, Pseudoalteromonas Exopolysaccharides, Farm extract that Pseudoalteromonas.

The emulsifier is represented by at least one substance selected from the group: sorbitan stearate, glyceryl stearate, the co-emulsifier is represented by at least one substance selected from the group: stearoxyhydroxypropyl methyl cellulose, hydrogenated lecithin.

The builder is represented by at least one substance selected from the group: behenyl alcohol, xanthan gum, hetearyl alcohol, cetyl alcohol. The preservative is represented by at least one substance selected from the group: methylparaben, polyparaben, the enhancer is sodium dextran sulfate. The antioxidant is represented by at least one substance selected from the group: tocopherol acetate, thiatin, the acidity regulator is citric acid. The anti-aging component is represented by at least one substance selected from the group: ascorbyltetraisopalmitate, acetylhexapeptide, tripeptide-10 citrulline, tripeptide-1.

The gelling agent is represented by at least one substance selected from the group: pectin, carbomer, ascorbyl tetraisopalmitate.

The regenerating component is represented by at least one substance selected from the group: dipotassium glycyrrhizinate, stearyl glycyrrhetinate.

The complexing agent is represented by the tetrasodium salt of EDTA,

The active substance is an olive leaf extract.

Prebiotic is represented by inulin.

The solvent is represented by at least one substance selected from the group: water, 1,3-butylene glycol.

In a most preferred embodiment, the invention relates to a cosmetic product in the following ratio of components:

In a preferred embodiment, the invention relates to a cosmetic product made in the form of a cream and intended for the care of facial skin.

In another embodiment, the invention relates to a comprehensive cosmetic skin care product containing a cosmetic composition in which the additional components are a moisturizer of 0.1-10% and / or an acidity regulator of 0.1-10%, and / or an emollient component 0, 1-10%, and / or a solubilizer of 1-5%, and / or a gelling agent of 2-10%, and / or a flavoring agent of 0.1-2%, and / or a preservative of 0.1-2%, and / or a warming component 0.1-2%, and / or a cooling agent 0.1-3%, and / or a complexing agent 0.1-3%, and / or vitamins 0.1-10%, and / or a regenerating component volume of 0.1-3%, and solvent up to 100%.

In a most preferred embodiment, the invention relates to a cosmetic product in which

the humidifier is represented by at least one substance selected from the group:

glycerin, butylene glycol, sodium hyaluronate, milk protein, lactose,

the acidity regulator is represented by at least one substance selected from the group: lactic acid, glycolic acid, sodium salicylate, citric acid, sodium lactate, malic acid, sodium citrate, tartaric acid,

the emollient component is represented by at least one substance selected from the group: panthenol, ethyl panthenol, panthenyl ethyl ether,

the solubilizer is represented by at least one substance selected from the group:

PEG-40 hydrogenated castor oil, PPG-26-Butez-26,

the gelling agent is represented by polyacrylic cross-polymer-6,

the flavoring is represented by at least one substance selected from the group:

eucalyptus oil, peppermint oil, Nigerian ginger essential oil,

a preservative is represented by at least one substance selected from the group:

methylisothiazolinone, methylchloroisothiazolinone,

the heating component is vanilla butyl ether,

the cooling agent is represented by at least one substance selected from the group: methyl PKA, methyl lactate,

the complexing agent is represented by the tetrasodium salt of EDTA,

vitamins are represented by at least one substance selected from the group:

niacinamide, ascorbic acid, biotin,

the regenerating component is represented by at least one substance selected from the group: pyridoxine hydrochloride, apigenin, oleanolic acid, inositol, acetylcysteine, acetylmethionine, biotinoyl tripeptide-1,

the solvent is represented by at least one substance selected from the group: water, isopentyldiol, dipropylene glycol, denatured alcohol.

In a preferred embodiment, the invention relates to a cosmetic product in the following ratio of components

In a preferred embodiment, the invention relates to a gel-based cosmetic product intended for the care of the scalp.

The compositions of the invention are cosmetic compositions intended for skin care. The resulting compositions have an anti-aging effect and a protective effect.

The term "Comprehensive cosmetic product" means a product of any form, preferably a cream or gel, which simultaneously has a regenerating, anti-aging, emollient, protective and anti-inflammatory effect.

Compositions of the invention include colloidal (nano) gold, colloidal (nano) silver, DMAE, ergotionine and arginine.

Gold

- interacts with proteases and copper that hydrolyze collagen, with elastases and other active components of connective tissues;

- trace element gold is able to enhance the bactericidal properties of silver, providing an antiseptic effect on bacteria and viruses;

- participates in the body's immune processes;

- participates in the processes of hormone binding in tissues;

- Gold in its nanostate penetrates the skin, attracts and holds in the deep layers of the water molecule, which enters the intercellular spaces. This causes “hydration from the inside” - hydration of not only the outer, but also the deep layers of the skin;

- with regular use, creates another layer, namely, a gold mesh;

- targeted delivery of useful drugs by gold nanobots directly to the cell at its atomic level.

Gold nanoparticles are significantly smaller in size and are able to penetrate deep into the skin tissue, not lingering in its upper layers and getting directly into the dermis. Gold nanoparticles are coated with a natural stabilizer and are absolutely biocompatible. Penetrating into the dermis, they stimulate the production of collagen by the cells of the dermis, and trigger the rejuvenation mechanisms laid down by nature, which is much more natural and environmentally friendly for the skin than injections (Botox, hyaluronic acid, etc.).

Gold nanoparticles trigger the mechanism of collagen production and help the skin to replenish, thereby giving a unique natural and eco-friendly anti-aging effect.

Due to its small size, gold nanoparticles penetrate into the deeper layers of the skin and effectively deliver active substances to where it is needed. Active substances placed on the surface of a particle penetrate with it into deep layers and are not consumed during delivery. Once in the cell, they immediately enter into metabolic processes and quickly saturate the cell with useful elements.

Silver

Colloidal (nano) silver is a universal antibacterial agent with a wide spectrum of action. The effect of the drug spreads to many bacteria. As a result of interaction with bacterial DNA molecules, silver ions destroy their functions, inhibiting the growth of microorganisms. It is noted that its variety can also affect microorganisms that are not able to acquire resistance to it. In addition, it was noted that colloidal silver does not have a destructive effect on tissue cells that produce beneficial enzymes. All of the above allows you to create new generation cosmetics on their basis.

Cosmetic effects of nanosilver:

1. Elimination of the causes of pustular and inflammatory rashes of pathogenic microorganisms.

Most inflammatory processes on the skin are associated with penetration of harmful microorganisms deep into its pores, which cannot be washed or eliminated in any other way. Silver nanoparticles, due to their size, are able to penetrate the lowest layers of the skin, and destroy all harmful microflora.

2. Skin regeneration. Silver nanoparticles effectively kill weak and old skin cells, causing a regenerative reaction of the body and accelerating the process of renewal of skin tissue.

3. Preservation. Silver nanoparticles are used as a natural preservative even in the food industry. Their ability to destroy microorganisms allows you to create hygienic and cosmetic products with a long shelf life.

4. Delivery of active components. Nanoparticles are used as effective suppliers of active ingredients to the deep layers of the skin. On their surface, you can precipitate a large number of different proteins and acids that penetrate into the desired areas and will not be stopped by the upper layers of the skin, which can significantly reduce the amount of active ingredient used and significantly increase the effectiveness of its use.

Arginine

This is one of the most important amino acids - a material for the synthesis of proteins, which is involved in the production of collagen necessary for skin elasticity, helps restore and heal, and also significantly improves complexion. Nitric oxide produced with arginine normalizes microcirculation in tissues and increases the tone of blood vessels.

Nitric oxide (arginine) is involved in the formation of substances that dilate blood vessels and stimulate the growth of blood vessels, improving blood circulation. So arginine improves the nutrition of all body tissues (and hair), prolonging their youth and improving recovery. This was proved by American scientists in the early 1990s, for which they were awarded the Nobel Prize in 1998. This amino acid is also able to increase creatine levels in tissues.

Cosmetic effects of arginine:

- lifting

- Stimulates microcirculation

- healing action

- Skin regeneration

- UV skin protection

- Protective function

- Conditioning hair. Arginine improves blood supply to the hair follicles, allowing them to get the maximum nutritional components for normal growth, shine and restoration of the structure.

DMAE

DMAE or dimethylaminoethanol is a natural nootropic, a precursor to acetylcholine, which is present in food and the human body and is produced by the body itself.

The effect of DMAE on the body:

- Retains water in connective tissue.

- Increases the conductivity of nerve impulses from the brain to the muscles, which tightens the muscles, delays progressive sagging (aging).

- Cleans cells from brown molecular waste (lipofuscin), thereby removing age spots.

- It has immunomodulatory and anti-inflammatory effects.

- the addition of dimethylaminoethanol to canned blood doubled its shelf life.

Ergotionein

- Ergotionein is by its nature an amino acid with a very powerful antioxidant activity of a wide spectrum of action, which can be used in the manufacture of cosmetics as an alternative to tocopherol and its derivatives. This is one of the few antioxidants (along with vitamins A, C and E) that has such a powerful protective effect that it can show beneficial effects in several directions at once. So, ergotionine as part of our skin care cosmetics protects epidermal cells from oxidative damage, DNA mutations, and also prevents dysfunction of the cell’s energy stations - mitochondria. In particular, ergotionine facilitates the transport of essential fatty acids to the mitochondria, which helps them use oxygen more efficiently and produce more energy. Thus, ergotionine indirectly increases cellular metabolism and simultaneously increases ATP synthesis, cellular respiration and cellular activity. Regarding the protection of DNA, ergotionein provides it by preventing oxidation of the guanine nucleotide.

- This ingredient has many other advantages - in particular, it prevents ultraviolet-induced damage to the skin and the destruction of collagen fibers. In addition to ultraviolet radiation, ergotionine protects the skin from many other aggressive environmental factors, such as heavy metals, air pollution, chlorine in water, etc. In addition, this component counteracts hyperpigmentation: when applied to the skin, ergotionein inhibits tyrosinase synthesis and, thus, slows down the production of melanin and evens skin tone.

Compositions of the invention may include amounts in%:

colloidal gold 1, 2, 3, 4, 5, 6, 7, 8, 9, 10

colloidal silver 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1

1.1, 1.2, 3.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2

2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3

3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4

4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 5

DMAE 1,2,3,4,5

Arginine 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1

Ergotionine 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1.

The amount of substance in the composition is given as a percentage of the total weight.

The quantitative interval of each substance of the cosmetic composition includes all the intermediate values of this interval.

Production technology

Face cream

Weigh the components of the fat phase.

Weigh the water and components of the aqueous phase.

Preheat the fat phase to 80 degrees.

Heat water with water-soluble additives to 90 degrees in a device with a water jacket and a homogenizing mixer.

With stirring, add the hot fat phase to the hot aqueous phase, mix and turn on the homogenizing device.

Homogenize for 10 minutes.

Put the unit on cooling.

At 40 degrees add the active ingredients and preservative, mix.

Check the mass for pH, give it to control.

Pack up.

Hair gel

Dissolve gelling agents in water. Stir and homogenize until smooth.

Add all other ingredients, including preservative and mix.

Check pH and check.

Pack up.

Physicochemical properties

Technical requirements

Face cream

TP TS 009/2011 “On the safety of perfumes and cosmetics”, Appendix 6, Appendix 7, Group 2, GOST 31460-2012 “Cosmetic creams. General specifications "

Technical requirements

Hair gel

TP TS 009/2011 "On the safety of perfumes and cosmetics", appendix 6, appendix 7, group 2, GOST 31695-2012 "Cosmetic gels. General specifications "

The invention will now be more fully explained using the following examples, which should not be construed as limiting it to the described embodiments.

Example 1

Face cream

Regulatory and technical documentation: TP TS 009/2011 "On the safety of perfumes and cosmetics", Appendix 6, Appendix 7, Group 2, GOST 31460-2012 "Cosmetic creams. General specifications "

Example 2

Hair Growth Gel

Example 3

Studies conducted on the skin of people of different ages have shown that the proposed complex cosmetic product with anti-aging and lifting effect maintains cellular activity (integral coefficient) at a level (0.46-0.48), close to the activity of cells of younger skin (0 , 51-0.53), which is reflected in the table.

Of particular note is the use of colloidal gold as a part of the claimed complex cosmetic product, due to which the formation of the finest golden mesh, which supports constant oxygenation and skin hydration, provides a continuous regeneration process, and externally tightens the skin of the face, making it and the face itself much younger. Regarding hair, a gradual restoration of their structure is ensured, growth is normalized, shine and density appear.

The combination of colloidal (nano) gold, colloidal (nano) silver, DMAE, ergotionein and arginine provides a triple effect:

1. colloidal (nano) gold has a lifting effect in the surface layers of the skin.

2. Nanoparticles of elements due to their small size penetrate to the basal layers of the skin and stimulate the processes of physiological renewal of the skin (anti-aging effect).

3. A colloidal solution of silver relieves inflammatory processes in the skin and powerfully stimulates local skin immunity.

In addition, the tool is hypoallergenic due to the use of natural organic substances for humans.

Sensory assessment.

A group of 4 women aged 20 to 50 years are invited to apply two cosmetics, one for each half of the face.

The assessment showed that the cosmetic product of example 1 (invention) is more convenient to use, smoother and more comfortable. Cosmetic prototype (comparison) gives a more oil effect for the skin, it is absorbed worse with a tendency to increase the visibility of protruding defects (pores, wrinkles). After application, such a tool leads to a harder and stickier film.

As a result, women from the group preferred the cosmetic product of example 1 (invention).

Claims (10)

1. Cosmetic composition for skin care, consisting of colloidal nano-gold, dimethylaminoethanol, colloidal nanosilver, ergotionine, arginine and additional components, where the additional components are emollients selected from at least one of the group: ethylhexyl palmitate, hydrogenated polydecene, hydrogenated , olive squalene, apricot oil, Rosa Canina fruit oil, isopropyl myristate, isononyl isononanoate, jojoba oil, cetyl palmitate, tertylhexanoin, phytosterols, macadamia nut oil, cholest eryl stearate, dimethicone / vinyl demythiconcrosspolymer, avocado oil; and / or ultraviolet filters selected from at least one of the group: ethylhexylmethoxycinnamate, cetylethylhexanoate, benzophenone-3, ethylhexyltriazone; and / or humectants selected from at least one of the group: glycerin, hydrolyzed soy protein, hydrolyzed vegetable protein, sodium hyaluronate, Centaurea cyanus flower extract, sodium sodium salt, Morus Alba root extract, Paeonia albiflora root extract, leaf extract Aloe Ferox, Sophora Angustifolia root extract, Pseudoalteromonas exopolysaccharides, Pseudoalteromonas enzyme extract; and / or emulsifiers selected from at least one of the group: sorbitan stearate, glyceryl stearate; and / or co-emulsifiers selected from at least one of the group: stearoxy hydroxypropyl methyl cellulose, hydrogenated lecithin; and / or structurants selected from at least one of the group: behenyl alcohol, xanthan gum, hetearyl alcohol, cetyl alcohol; and / or preservatives selected from at least one of the group: methylparaben, propylparaben; and / or an enhancer, which is sodium dextran sulfate; and / or antioxidants selected from at least one of the group: tocopherol acetate, thiatin; and / or an acidity regulator, which is citric acid; and / or anti-aging components selected from at least one of the group: ascorbyltetraisopalmitate, acetylhexapeptide-37, tripeptide-10 citrulline, tripeptide-1; and / or gelling agents selected from at least one of the group: pectin, carbomer; and / or regenerating components selected from at least one of the group: dipotassium glycyrrhizinate, stearyl glycyrrhetinate; and / or a complexing agent, which is a tetrasodium salt of EDTA; and / or an active substance, which is an extract of olive leaves; and / or a prebiotic representing inulin; and / or solvents selected from at least one of the group: water, 1,3-butylene glycol, where the components of the composition are in the following ratio in wt.%: colloidal nanogold 1-10 dimethylaminoethanol 1-5 colloidal nanosilver 0.1-5 ergotionein 0.01-1 arginine 0.01-1 additional components: emollients 0.01-35 ultraviolet filters 3-25 humidifiers 0,1-10 emulsifiers 5-25 co-emulsifiers 2-10 builders 0.5-10 preservatives 0.2-2 enhancers 0.1-0.5 antioxidants 0.2-1 acidity regulator 0.1-0.5 anti-aging components 0.1-25 gelling agents 0.2-2 regenerative components 0.5-3 complexing agents 0.1-0.5 active substance 0.1-0.5 prebiotic 0.1-0.5 solvents up to 100 2. The cosmetic composition according to claim 1, characterized in that it is intended for facial skin care. 3. The cosmetic composition according to claim 1, characterized in that it is intended for the care of the scalp. 4. The cosmetic composition according to claim 1, characterized in that it is made in the form of a cream. 5. The use of the cosmetic composition according to claim 1 to obtain a comprehensive cosmetic products for skin care. 6. A comprehensive cosmetic skin care product consisting of colloidal nano-gold, dimethylaminoethanol, colloidal nanosilver, ergotionine, arginine and auxiliary components, where the additional components are moisturizers selected from at least one of the group: glycerin, butylene glycol, hyaluronate sodium, milk protein, lactose; and / or acidity regulators selected from at least one of the group: lactic acid, glycolic acid, sodium salicylate, citric acid, sodium lactate, malic acid, sodium citrate, tartaric acid; and / or emollients selected from at least one of the group: panthenol, ethyl panthenol, panthenyl ethyl ether; and / or solubilizers selected from at least one of the group: PEG-40 hydrogenated castor oil, PPG-26-Butez-26; and / or a gelling agent, which is a polyacrylic cross-polymer-6; and / or flavorings selected from at least one of the group: eucalyptus oil, peppermint oil, Nigerian ginger essential oil; and / or preservatives selected from at least one of the group: methylisothiazolinone, methylchloroisoisiazolinone; and / or a heating component, which is vanilla butyl ether; and / or cooling agents selected from at least one of the group: methyl PKA, methyl lactate; and / or a complexing agent, which is a tetrasodium salt of EDTA; and / or vitamins selected from at least one of the group: niacinamide, ascorbic acid, biotin; and / or regenerating components selected from at least one of the group: pyridoxine hydrochloride, apigenin, oleanolic acid, inositol; and solvents selected from at least one of the group: water, isopentyldiol, dipropylene glycol, denatured alcohol, where the components of the composition are in the following ratio, in wt.%: colloidal nanogold 1-10 dimethylaminoethanol 1-5 colloidal nanosilver 0.1-5 ergotionein 0.01-1 arginine 0.01-1 additional components: humidifiers 0,1-10 acidity regulators 0,1-10 emollient components 0,1-10 solubilizers 1-5 gelling agents 2-10 flavorings 0.1-2 preservatives 0.1-2 heating components 0.1-2 cooling agents 0.1-3 complexing agents 0.1-3 vitamins 0,1-10 gelling agents 0.2-2 regenerative components 0.1-3 solvents up to 100 7. The complex cosmetic product according to claim 6, characterized in that it is intended for the care of the scalp. 8. The complex cosmetic according to claim 6, characterized in that it is made in the form of a gel.