CN110267954A - 苯胺取代的1,2-二氢吡咯并[3,4-c]吡啶/嘧啶-3-酮衍生物及用途 - Google Patents

苯胺取代的1,2-二氢吡咯并[3,4-c]吡啶/嘧啶-3-酮衍生物及用途 Download PDF

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CN110267954A
CN110267954A CN201880010505.2A CN201880010505A CN110267954A CN 110267954 A CN110267954 A CN 110267954A CN 201880010505 A CN201880010505 A CN 201880010505A CN 110267954 A CN110267954 A CN 110267954A
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alkoxy
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halogenated
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CN110267954B (zh
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郭淑春
周福生
陈祥
赵金柱
黄栋
谢婧
乔长江
何宛
张凯
陈曦
兰炯
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Yangtze River Pharmaceutical Group Co Ltd
Shanghai Haiyan Pharmaceutical Technology Co Ltd
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Shanghai Haiyan Pharmaceutical Technology Co Ltd
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Abstract

本发明涉及N‑(3‑氨基苯基)丙烯酰胺取代的1,2‑二氢吡咯并[3,4‑c]吡啶/嘧啶‑3‑酮衍生物、其制法与医药上的用途。具体地，本发明公开了式(II)化合物或其药学上可接受的盐、立体异构体、溶剂化物或前药，及其制备方法和应用，式中各基团的定义详见说明书和权利要求书。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201880010505.2A 2017-09-28 2018-08-03 苯胺取代的1,2-二氢吡咯并[3,4-c]吡啶/嘧啶-3-酮衍生物及用途 Active CN110267954B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710897909 2017-09-28
CN2017108979095 2017-09-28
PCT/CN2018/098479 WO2019062328A1 (zh) 2017-09-28 2018-08-03 苯胺取代的1,2-二氢吡咯并[3,4-c]吡啶/嘧啶-3-酮衍生物及用途

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CN110267954A true CN110267954A (zh) 2019-09-20
CN110267954B CN110267954B (zh) 2022-05-10

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CN201880010483.XA Active CN110366553B (zh) 2017-09-28 2018-08-03 4,6,7-三取代1,2-二氢吡咯并[3,4-c]吡啶/嘧啶-3-酮衍生物及用途
CN201880010505.2A Active CN110267954B (zh) 2017-09-28 2018-08-03 苯胺取代的1,2-二氢吡咯并[3,4-c]吡啶/嘧啶-3-酮衍生物及用途
CN202210278145.2A Active CN114478544B (zh) 2017-09-28 2018-08-03 4,6,7-三取代1,2-二氢吡咯并[3,4-c]吡啶/嘧啶-3-酮衍生物及用途

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US (2) US11174254B2 (zh)
EP (1) EP3689871B1 (zh)
JP (1) JP6922085B2 (zh)
CN (3) CN110366553B (zh)
AU (1) AU2018342342B2 (zh)
CA (1) CA3077238C (zh)
DK (1) DK3689871T3 (zh)
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Cited By (1)

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CN113061137A (zh) * 2021-04-02 2021-07-02 广西医科大学 含氮杂环衍生物或其药学上可接受的盐和用途

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KR20190043437A (ko) 2017-10-18 2019-04-26 씨제이헬스케어 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
CA3109765A1 (en) * 2019-03-18 2020-09-24 Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Btk inhibitor, pharmaceutically acceptable salt, polymorph and application thereof
WO2022048551A1 (zh) * 2020-09-01 2022-03-10 上海海雁医药科技有限公司 布鲁顿酪氨酸激酶抑制剂的多晶型物及其制备方法和应用

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Publication number Priority date Publication date Assignee Title
CN113061137A (zh) * 2021-04-02 2021-07-02 广西医科大学 含氮杂环衍生物或其药学上可接受的盐和用途

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US11155546B2 (en) 2021-10-26
CN114478544B (zh) 2023-06-16
EP3689871A1 (en) 2020-08-05
JP6922085B2 (ja) 2021-08-18
AU2018342342B2 (en) 2021-01-07
JP2020535170A (ja) 2020-12-03
US20200223846A1 (en) 2020-07-16
SG11202002767RA (en) 2020-04-29
CN110366553B (zh) 2022-04-15
EP3689871A4 (en) 2020-08-05
WO2019062328A1 (zh) 2019-04-04
DK3689871T3 (da) 2021-12-06
CN110267954B (zh) 2022-05-10
US11174254B2 (en) 2021-11-16
EP3689871B1 (en) 2021-09-29
WO2019062329A1 (zh) 2019-04-04
AU2018342342A1 (en) 2020-04-16
CN114478544A (zh) 2022-05-13
US20200048248A1 (en) 2020-02-13
CA3077238A1 (en) 2019-04-04
CN110366553A (zh) 2019-10-22
CA3077238C (en) 2022-04-12

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