CN110251694A - A kind of contrast medium for stomach and intestine ultrasonic imaging and preparation method thereof - Google Patents
A kind of contrast medium for stomach and intestine ultrasonic imaging and preparation method thereof Download PDFInfo
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- 239000002872 contrast media Substances 0.000 title claims abstract description 73
- 210000002784 stomach Anatomy 0.000 title claims abstract description 66
- 238000003384 imaging method Methods 0.000 title claims abstract description 52
- 210000000936 intestine Anatomy 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims description 23
- 241001313857 Bletilla striata Species 0.000 claims abstract description 29
- 240000002853 Nelumbo nucifera Species 0.000 claims abstract description 28
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims abstract description 28
- 241000209140 Triticum Species 0.000 claims abstract description 26
- 235000021307 Triticum Nutrition 0.000 claims abstract description 26
- 239000002994 raw material Substances 0.000 claims abstract description 25
- 210000000582 semen Anatomy 0.000 claims abstract description 21
- 235000013312 flour Nutrition 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims description 40
- 230000001954 sterilising effect Effects 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 238000005538 encapsulation Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 235000020985 whole grains Nutrition 0.000 claims description 4
- 230000000295 complement effect Effects 0.000 claims description 3
- 238000010411 cooking Methods 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
- 239000003814 drug Substances 0.000 abstract description 9
- 239000002245 particle Substances 0.000 abstract description 6
- 238000002604 ultrasonography Methods 0.000 abstract description 6
- 238000003759 clinical diagnosis Methods 0.000 abstract description 4
- 229920002472 Starch Polymers 0.000 abstract description 3
- 206010061577 Ulcer haemorrhage Diseases 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 3
- 230000001926 lymphatic effect Effects 0.000 abstract description 3
- 235000019698 starch Nutrition 0.000 abstract description 3
- 239000008107 starch Substances 0.000 abstract description 3
- 239000002562 thickening agent Substances 0.000 abstract description 3
- 241001313855 Bletilla Species 0.000 abstract description 2
- 238000010410 dusting Methods 0.000 description 24
- 238000012360 testing method Methods 0.000 description 19
- 230000002496 gastric effect Effects 0.000 description 8
- 238000009835 boiling Methods 0.000 description 6
- 238000003745 diagnosis Methods 0.000 description 4
- 230000036541 health Effects 0.000 description 3
- 239000010977 jade Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000002601 radiography Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
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Abstract
The present invention provides a kind of contrast medium for stomach and intestine ultrasonic imaging, it is prepared by the raw material of following weight proportion: 40~70 parts of wheat flour, 15~30 parts of Semen sesami nigrum, 5~18 parts of lotus root, 1~10 part of the bletilla striata.Contrast medium for stomach and intestine ultrasonic imaging particle of the present invention is fine and smooth, modulates simple and convenient, anhydrous, solute layering, not will form hot spot and causes pseudomorphism, ultrasonic resolution ratio is high, and obtained ultrasound image is very clear, more conducively clinical diagnosis.Bletilla stem tuber can make thickener, can also be used as medicine containing lymphatic temperament and starch etc. simultaneously, have dual-purpose of drug and food, have a certain effect to protection hemorrhagic ulcer stomach lining.
Description
Technical field
The invention belongs to medical supplies technical fields, and in particular to a kind of contrast medium for stomach and intestine ultrasonic imaging and preparation method thereof.
Background technique
The imageological examination of gastrointestinal disease is always based on gastroscope, barivm meal fluoroscopy (screem) and CT, due to stomach intestinal gas and interior
Tolerant interference, ultrasound are limited in the application of gastrointestinal tract.This situation has been broken in the appearance of contrast medium for stomach and intestine ultrasonic imaging, keeps stomach and intestine super
Acoustic inspection is possibly realized.Currently, in the contrast medium for stomach and intestine ultrasonic imaging product of clinical use, it is representational such as: thin jade rosy clouds application
Color gastrointestinal ultrasonic contrast medium patent (number of patent application CN1403160) and Zhang Fudong application color gastrointestinal ultrasonic contrast medium
Patent (number of patent application CN1535730) and " heart jade tablet " board stomach window acoustic contrast of Hangzhou, Zhejiang province Hu Qingyu Pharmaceutical Workshop production
" world " board gastro intestinal ultrasonic assistant produced with Huzhou City East Asia medical supplies Co., Ltd.Recorded in preceding binomial patent application
Contrast agent using Chinese medicine preparation constitute, though they have certain health protection and therapeutic action, ultrasonic image display effect
Generally, and it is complex cumbersome using modulator approach, do not pay attention to slightly looking or modulating inadequate, will result in pseudomorphism, influence to examine
Disconnected effect.That then there is particles is big for " world " board gastro intestinal ultrasonic assistant, and echo is owed uniformly and water and contrast agent solute are easily layered,
The disadvantages of hot spot causes pseudomorphism is formed, to influence its diagnosis effect.Also there is brewed for " heart jade tablet " board stomach window acoustic contrast
Cumbersome, easily agglomeration deposits, and forms the disadvantages of hot spot influences diagnosis.As it can be seen that current contrast medium for stomach and intestine ultrasonic imaging localization diagnosis effect is all
It has certain problems.
Summary of the invention
To solve the above-mentioned problems, the present invention provides a kind of contrast medium for stomach and intestine ultrasonic imaging and preparation method thereof.
The present invention provides a kind of contrast medium for stomach and intestine ultrasonic imaging, it is prepared by the raw material of following weight proportion: wheat
40~70 parts of powder, 15~30 parts of Semen sesami nigrum, 5~18 parts of lotus root, 1~10 part of the bletilla striata.
Further, contrast medium for stomach and intestine ultrasonic imaging above-mentioned is prepared by the raw material of following weight proportion: wheat flour 60
Part, 25 parts of Semen sesami nigrum, 10 parts of lotus root, 5 parts of the bletilla striata；
Or 50 parts of wheat flour, 20 parts of Semen sesami nigrum, 15 parts of lotus root, 5 parts of the bletilla striata.
Further, the wheat flour is that will crush after wheat frying, the powder sieved with 100 mesh sieve；The Semen sesami nigrum
Will to be crushed after Semen sesami nigrum frying, the powder sieved with 100 mesh sieve；The lotus root is to crush after cooking lotus root, sieves with 100 mesh sieve to obtain
Powder；The bletilla striata is that the bletilla striata is boiled to no Bai Xinhou to the powder for crushing, sieving with 100 mesh sieve.
Further, it crushes after the frying by wheat to be fried with slow fire yellow, cools, crush；It is described to fry Semen sesami nigrum
Crushing after system is that mild fire is fried 3-5 minutes, cools, crushes；It is described lotus root is cooked after crush to dry after cooking lotus root, crush；Institute
It states to boil the bletilla striata to no Bai Xinhou and crush to boil the bletilla striata to no Bai Xinhou, taking-up is dried, and crust is removed, and is crushed.
Further, contrast medium for stomach and intestine ultrasonic imaging above-mentioned is after being mixed by the raw material of the weight proportion, in addition pharmaceutically
The contrast agent that acceptable auxiliary material preparation or complementary ingredient are prepared.
Further, the contrast agent is powder-type contrast agent, granular pattern contrast agent or solvent type contrast agent.
The present invention also provides a kind of preparation methods of contrast medium for stomach and intestine ultrasonic imaging above-mentioned, it includes the following steps: to weigh
The raw material of aforementioned weight proportion, after raw material is mixed, in addition the preparation of pharmaceutically acceptable auxiliary material or complementary ingredient, i.e.,
?.
Further, preparation method above-mentioned includes the following steps:
Weigh aforementioned weight proportion raw material, raw material is mixed directly, sterilize, encapsulation to get；
Or, weighing the raw material of aforementioned weight proportion, raw material is uniformly mixed, it is dry, it carries out expanding treatment and is in granular form, it is whole
Grain, sterilizing, encapsulation to get；
Or, weighing the raw material of aforementioned weight proportion, raw material is uniformly mixed, the water of 5 times of amounts (v/w) is added, stirs evenly,
Sterilizing, encapsulation to get.
Further, the sterilizing is high-temperature sterilization.
V/w is mL/g in the present invention, represents volume mass ratio.
Contrast medium for stomach and intestine ultrasonic imaging particle of the present invention is fine and smooth, and modulation is simple and convenient, and anhydrous, solute layering not will form hot spot
Pseudomorphism is caused, ultrasonic resolution ratio is high, and obtained ultrasound image is very clear, more conducively clinical diagnosis.Bletilla simultaneously
Stem tuber can make thickener, can also be used as medicine containing lymphatic temperament and starch etc., have dual-purpose of drug and food, glutinous to protection hemorrhagic ulcer stomach
Film has a certain effect.
Obviously, above content according to the present invention is not being departed from according to the ordinary technical knowledge and customary means of this field
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The specific embodiment of form by the following examples remakes further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on above content of the present invention
The technology realized all belongs to the scope of the present invention.
Specific embodiment
Raw material, equipment used in the specific embodiment of the invention are known product, are obtained by purchase commercial product.
The preparation of embodiment 1, contrast medium for stomach and intestine ultrasonic imaging of the present invention
Wheat 60g, Semen sesami nigrum 25g, lotus root 10g, bletilla striata 5g are weighed in proportion.Net wheat is set in frying container, mild fire is fried
It to yellow, takes out, cools when tack-free, crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Net Semen sesami nigrum is set frying to hold
In device, mild fire is fried 3-5 minutes, is taken out, is cooled when tack-free, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Lotus root is washed
Only, after slice cooks, taking-up is dried, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；The net bletilla striata is set boiled in boiling water to
Without the white heart, taking-up is dried, and removes crust, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Above-mentioned fine powder is uniformly mixed,
High-temperature sterilization, is packaged according to 50g/ bags of standard, that is, the contrast medium for stomach and intestine ultrasonic imaging of powder-type is made.
The preparation of embodiment 2, contrast medium for stomach and intestine ultrasonic imaging of the present invention
Wheat 60g, Semen sesami nigrum 25g, lotus root 10g, bletilla striata 5g are weighed in proportion.Net wheat is set in frying container, mild fire is fried
It to yellow, takes out, cools when tack-free, crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Net Semen sesami nigrum is set frying to hold
In device, mild fire is fried 3-5 minutes, is taken out, is cooled when tack-free, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Lotus root is washed
Only, after slice cooks, taking-up is dried, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；The net bletilla striata is set boiled in boiling water to
Without the white heart, taking-up is dried, and removes crust, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Above-mentioned fine powder is uniformly mixed,
It is dry, it carries out expanding treatment and is in granular form, after whole grain, high-temperature sterilization is packaged according to 50g/ bags of standard, that is, particle is made
The contrast medium for stomach and intestine ultrasonic imaging of type.
The preparation of embodiment 3, contrast medium for stomach and intestine ultrasonic imaging of the present invention
Wheat 60g, Semen sesami nigrum 25g, lotus root 10g, bletilla striata 5g are weighed in proportion.Net wheat is set in frying container, mild fire is fried
It to yellow, takes out, cools when tack-free, crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Net Semen sesami nigrum is set frying to hold
In device, mild fire is fried 3-5 minutes, is taken out, is cooled when tack-free, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Lotus root is washed
Only, after slice cooks, taking-up is dried, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；The net bletilla striata is set boiled in boiling water to
Without the white heart, taking-up is dried, and removes crust, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Above-mentioned fine powder is uniformly mixed,
Then the contrast medium for stomach and intestine ultrasonic imaging of powder-type is placed in container by part (50 grams/bag), and 500 milliliters of aqueous solution is added, it will
It is stirred, and high-temperature sterilization is packaged, that is, solvent type contrast medium for stomach and intestine ultrasonic imaging is made.
The preparation of embodiment 4, contrast medium for stomach and intestine ultrasonic imaging of the present invention
Wheat 50g, Semen sesami nigrum 20g, lotus root 15g, bletilla striata 5g are weighed in proportion.Net wheat is set in frying container, mild fire is fried
It to yellow, takes out, cools when tack-free, crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Net Semen sesami nigrum is set frying to hold
In device, mild fire is fried 3-5 minutes, is taken out, is cooled when tack-free, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Lotus root is washed
Only, after slice cooks, taking-up is dried, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；The net bletilla striata is set boiled in boiling water to
Without the white heart, taking-up is dried, and removes crust, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Above-mentioned fine powder is uniformly mixed,
High-temperature sterilization, is packaged according to 50g/ bags of standard, that is, the contrast medium for stomach and intestine ultrasonic imaging of powder-type is made.
The preparation of embodiment 5, contrast medium for stomach and intestine ultrasonic imaging of the present invention
Wheat 50g, Semen sesami nigrum 20g, lotus root 15g, bletilla striata 5g are weighed in proportion.Net wheat is set in frying container, mild fire is fried
It to yellow, takes out, cools when tack-free, crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Net Semen sesami nigrum is set frying to hold
In device, mild fire is fried 3-5 minutes, is taken out, is cooled when tack-free, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Lotus root is washed
Only, after slice cooks, taking-up is dried, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；The net bletilla striata is set boiled in boiling water to
Without the white heart, taking-up is dried, and removes crust, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Above-mentioned fine powder is uniformly mixed,
It is dry, it carries out expanding treatment and is in granular form, after whole grain, high-temperature sterilization is packaged according to 50g/ bags of standard, that is, particle is made
The contrast medium for stomach and intestine ultrasonic imaging of type.
The preparation of embodiment 6, contrast medium for stomach and intestine ultrasonic imaging of the present invention
Wheat 50g, Semen sesami nigrum 20g, lotus root 15g, bletilla striata 5g are weighed in proportion.Net wheat is set in frying container, mild fire is fried
It to yellow, takes out, cools when tack-free, crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Net Semen sesami nigrum is set frying to hold
In device, mild fire is fried 3-5 minutes, is taken out, is cooled when tack-free, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Lotus root is washed
Only, after slice cooks, taking-up is dried, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；The net bletilla striata is set boiled in boiling water to
Without the white heart, taking-up is dried, and removes crust, and crushing is ground, and is crossed 100 mesh dusting covers, is obtained fine powder, spare；Above-mentioned fine powder is uniformly mixed,
Then the contrast medium for stomach and intestine ultrasonic imaging of powder-type is placed in container by part (50 grams/bag), and 500 milliliters of aqueous solution is added, it will
It is stirred, and high-temperature sterilization is packaged, that is, solvent type contrast medium for stomach and intestine ultrasonic imaging is made.
Beneficial effects of the present invention are proved below by way of specific test example.
The research of test example 1, contrast medium for stomach and intestine ultrasonic imaging ultrasonic image display effect of the present invention
Acoustic contrast agent of the present invention, is modulated by acoustic contrast agent prepared by Example 1 with 37 DEG C of warm waters of 500ml
Paste is given gastro intestinal ultrasonic radiography person to be carried out and is taken, and disposably takes orally 200ml, carries out ultrasonic examination after taking immediately, according to
Stomach and intestine fill situation and increase radiography dosage, and research on maximum utilized quantity is no more than 500ml.It is shown through clinical ultrasound image, gastral cavity entrant sound is good
Uniformly, 5 layers of Structure Comparison degree of stomach wall " Sanming City two is dark " are clear, and imaging results are good.
The comparison of test example 2, contrast medium for stomach and intestine ultrasonic imaging ultrasonic image display effect
Test group: contrast medium for stomach and intestine ultrasonic imaging prepared by the embodiment of the present invention 1.
Control group: raw material proportioning is wheat 40g, Semen sesami nigrum 15g, lotus root 10g, bletilla striata 5g, according to the preparation method of embodiment 1
Prepare contrast medium for stomach and intestine ultrasonic imaging.
Using Health College Students as subjects, men and women is unlimited, and the age 10-23 years old, control group and test group each 50, with stomach
Chamber entrant sound, display stomach wall " Sanming City two is dark " structure are target, compare the imaging results of different ratio.In clear 5 layers of stomach wall of display
Configuration aspects, control group clearly show 36, and test group clearly shows 47, and test group is better than control group (p < 0.05)；In stomach
In terms of chamber entrant sound, control group entrant sound is uniform 33 good, and test group entrant sound is uniform 46 good, and test group is better than control group (p <
0.05)。
The comparison of test example 3, contrast medium for stomach and intestine ultrasonic imaging ultrasonic image display effect
Test group: contrast medium for stomach and intestine ultrasonic imaging prepared by the embodiment of the present invention 5.
Control group: raw material is Semen sesami nigrum 90g, prepares contrast medium for stomach and intestine ultrasonic imaging according to the preparation method of embodiment 5.
Using Health College Students as subjects, men and women is unlimited, and the age 10-23 years old, control group and test group each 50, with stomach
Chamber entrant sound, display stomach wall " Sanming City two is dark " structure are target, compare the imaging results of control group and test group.In clearly display stomach
5 layers of configuration aspects of wall, control group clearly show 5, and test group clearly shows 46, and test group is better than control group (p < 0.05)；
In terms of gastral cavity entrant sound, control group entrant sound is uniform 4 good, and test group entrant sound is uniform 48 good, and test group is better than control group
(p < 0.05).
The comparison of test example 4, contrast medium for stomach and intestine ultrasonic imaging ultrasonic image display effect
In order to further verify the effect of this contrast medium for stomach and intestine ultrasonic imaging, it is provided with and the limited public affairs of Huzhou City East Asia medical supplies
Take charge of the check experiment of " world " board gastro intestinal ultrasonic assistant of production.By between 2 months in March, 2019 in 2018, Shaanxi traditional Chinese medicine
The patient that the stomach and intestine outpatient service of affiliated hospital, university needs to do gastro intestinal ultrasonic is randomly divided into 2 groups, and first group and second group are 235 people, the age,
Gender, weight isobase condition are without statistics difference (p > 0.05), and using gastroscope or pathology as goldstandard, it is super to compare two kinds of stomach and intestine
The imaging of sound contrast agent and diagnosis effect.First group takes the acoustic contrast agent of the preparation of the embodiment of the present invention 1, and second group takes control group
" world " board gastro intestinal ultrasonic assistant, two groups of contrast agent taking doses are the optimal dosage of the contrast agent effect.Clear
Clear 5 layers of configuration aspects of display stomach wall, this contrast agent clearly show 221, and " world " board contrast agent clearly shows 207, originally makes
Shadow agent is better than " world " board contrast agent (p < 0.05)；In terms of diagnosing gastric ulcer, this contrast agent diagnoses 43, and " world " board is made
Shadow agent diagnoses 35, this contrast agent is better than " world " board contrast agent (p < 0.05).
Test result explanation, contrast medium for stomach and intestine ultrasonic imaging imaging results prepared by the present invention are greatly improved, better than existing
There is the contrast medium for stomach and intestine ultrasonic imaging in technology, obtained ultrasound image is more clear, more conducively clinical diagnosis.
To sum up, contrast medium for stomach and intestine ultrasonic imaging particle of the present invention is fine and smooth, and modulation is simple and convenient, and anhydrous, solute layering not will form
Hot spot causes pseudomorphism, and ultrasonic resolution ratio is high, and obtained ultrasound image is very clear, more conducively clinical diagnosis.Chinese medicine simultaneously
Bletilla striata stem tuber can make thickener, can also be used as medicine containing lymphatic temperament and starch etc., have dual-purpose of drug and food, to protection hemorrhagic ulcer
Stomach lining has a certain effect.
Claims (9)
1. a kind of contrast medium for stomach and intestine ultrasonic imaging, it is characterised in that: it is prepared by the raw material of following weight proportion: wheat flour 40
~70 parts, 15~30 parts of Semen sesami nigrum, 5~18 parts of lotus root, 1~10 part of the bletilla striata.
2. contrast medium for stomach and intestine ultrasonic imaging according to claim 1, it is characterised in that: it is by the raw material system of following weight proportion
It is standby to form: 60 parts of wheat flour, 25 parts of Semen sesami nigrum, 10 parts of lotus root, 5 parts of the bletilla striata；
Or 50 parts of wheat flour, 20 parts of Semen sesami nigrum, 15 parts of lotus root, 5 parts of the bletilla striata.
3. contrast medium for stomach and intestine ultrasonic imaging according to claim 1 or 2, it is characterised in that: the wheat flour is by wheat frying
After crush, the powder sieved with 100 mesh sieve；The Semen sesami nigrum is that will crush after Semen sesami nigrum frying, the powder sieved with 100 mesh sieve
End；The lotus root is to crush after cooking lotus root, the powder sieved with 100 mesh sieve；The bletilla striata is to boil the bletilla striata to no Bai Xinhou powder
Powder that is broken, sieving with 100 mesh sieve.
4. contrast medium for stomach and intestine ultrasonic imaging according to claim 3, it is characterised in that: crush after the frying by wheat as mild fire
It fries to yellow, cools, crush；It crushes after the frying by Semen sesami nigrum and is fried 3-5 minutes for mild fire, cooled, crushed；It is described to steam lotus root
It after crushing after ripe to cook lotus root, dries, crushes；Described boil the bletilla striata to no Bai Xinhou crushes to boil the bletilla striata to without the white heart
Afterwards, taking-up is dried, and removes crust, is crushed.
5. contrast medium for stomach and intestine ultrasonic imaging according to claim 1 or 2, it is characterised in that: it is by the original of the weight proportion
After material mixing, in addition the contrast agent that the preparation of pharmaceutically acceptable auxiliary material or complementary ingredient are prepared.
6. contrast medium for stomach and intestine ultrasonic imaging according to claim 5, it is characterised in that: the contrast agent be powder-type contrast agent,
Granular pattern contrast agent or solvent type contrast agent.
7. a kind of preparation method of the described in any item contrast medium for stomach and intestine ultrasonic imaging of claim 1~6, it is characterised in that: it includes
Following steps: weighing the raw material of aforementioned weight proportion, after raw material is mixed, in addition the preparation or auxiliary of pharmaceutically acceptable auxiliary material
Helping property ingredient to get.
8. preparation method according to claim 7, it is characterised in that: it includes the following steps:
Weigh aforementioned weight proportion raw material, raw material is mixed directly, sterilize, encapsulation to get；
Or, weighing the raw material of aforementioned weight proportion, raw material is uniformly mixed, it is dry, it carries out expanding treatment and is in granular form, whole grain,
Sterilizing, encapsulation to get；
Or, weighing the raw material of aforementioned weight proportion, raw material is uniformly mixed, the water of 5 times of amounts (v/w) is added, stirs evenly, goes out
Bacterium, encapsulation to get.
9. preparation method according to claim 8, it is characterised in that: the sterilizing is high-temperature sterilization.
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87105799A (en) * | 1987-08-26 | 1988-04-06 | 贵阳中医学院第二附属医院 | The manufacturing process of B ultrasonic gastrointestinal contrast agent |
| CN1403160A (en) * | 2001-09-04 | 2003-03-19 | 薄玉霞 | Color gastrointestinal ultrasonic contrast medium |
| CN1634600A (en) * | 2004-11-12 | 2005-07-06 | 蓝锋 | Ultrasonic contrast medium with echo for stomach and intestine |
| CN1721000A (en) * | 2005-06-22 | 2006-01-18 | 蓝锋 | Gastrointestinal ultrasonic contrast medium with echo and its preparation process |
| CN105497924A (en) * | 2016-02-18 | 2016-04-20 | 卢立征 | Development assistance traditional Chinese medicine used for B ultrasonography |
| CN106075477A (en) * | 2016-05-27 | 2016-11-09 | 任玉锋 | A kind of color ultrasound is with helping shadow medicine |
| CN107551280A (en) * | 2016-12-26 | 2018-01-09 | 王淑霞 | A kind of alimentary canal acoustic contrast agent suitable for the unbalance patient of gut flora |
| CN108419983A (en) * | 2018-02-16 | 2018-08-21 | 张雷 | A kind of gastrointestinal tract ultrasonic wave imaging assistant meal replacement powder and preparation method thereof |
-
2019
- 2019-07-15 CN CN201910636746.4A patent/CN110251694B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87105799A (en) * | 1987-08-26 | 1988-04-06 | 贵阳中医学院第二附属医院 | The manufacturing process of B ultrasonic gastrointestinal contrast agent |
| CN1403160A (en) * | 2001-09-04 | 2003-03-19 | 薄玉霞 | Color gastrointestinal ultrasonic contrast medium |
| CN1634600A (en) * | 2004-11-12 | 2005-07-06 | 蓝锋 | Ultrasonic contrast medium with echo for stomach and intestine |
| CN1721000A (en) * | 2005-06-22 | 2006-01-18 | 蓝锋 | Gastrointestinal ultrasonic contrast medium with echo and its preparation process |
| CN105497924A (en) * | 2016-02-18 | 2016-04-20 | 卢立征 | Development assistance traditional Chinese medicine used for B ultrasonography |
| CN106075477A (en) * | 2016-05-27 | 2016-11-09 | 任玉锋 | A kind of color ultrasound is with helping shadow medicine |
| CN107551280A (en) * | 2016-12-26 | 2018-01-09 | 王淑霞 | A kind of alimentary canal acoustic contrast agent suitable for the unbalance patient of gut flora |
| CN108419983A (en) * | 2018-02-16 | 2018-08-21 | 张雷 | A kind of gastrointestinal tract ultrasonic wave imaging assistant meal replacement powder and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 邱伟等: "一种高效廉价的胃肠超声造影剂替代品的探讨", 《临床合理用药》 * |
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