CN1721000A - Gastrointestinal ultrasonic contrast medium with echo and its preparation process - Google Patents
Gastrointestinal ultrasonic contrast medium with echo and its preparation process Download PDFInfo
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- CN1721000A CN1721000A CN 200510050197 CN200510050197A CN1721000A CN 1721000 A CN1721000 A CN 1721000A CN 200510050197 CN200510050197 CN 200510050197 CN 200510050197 A CN200510050197 A CN 200510050197A CN 1721000 A CN1721000 A CN 1721000A
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Abstract
The invention discloses a gastrointestinal ultrasonic contrast medium with echo and its preparation process, wherein the contrast agent is prepared from distilled apple grain, maize flour and lotus root starch as raw material, and the contrast agent is made into the forms of particles, powders and solvents through three different techniques. The prepared contrast agent has good taste and causes no side effect to stomach and intestine.
Description
One, technical field:
The present invention relates to a kind of contrast agent of checking gastrointestinal disease and preparation method thereof that is used to, belong to the medical supplies technical field.
Two, background technology:
At present, employed contrast agent product category is various in the ultrasonic diagnosis of gastrointestinal disease is checked, its representational as: the color gastrointestinal ultrasonic contrast medium patent (number of patent application CN1535730) of the color gastrointestinal ultrasonic contrast medium patent (number of patent application CN1403160) of Bao Yuxia application and Zhang Fudong application, and " heart jade tablet " board stomach window acoustic contrast of producing of Hu Qingyu Pharmaceutical Workshop, Hangzhou, Zhejiang province and " all over the world " board gastro intestinal ultrasonic contrast agent of Huzhou City East Asia medical supplies company limited production.The contrast agent that preceding binomial patent application is put down in writing is to adopt Chinese medicine preparation to constitute, though it has certain health protection and therapeutic action, but the ultrasonic image display effect is general, and use modulator approach comparatively complicated, loaded down with trivial details, do not note slightly taking care or modulating inadequate, will cause pseudomorphism, influence diagnosis effect." all over the world " then to exist granule big for board gastro intestinal ultrasonic contrast agent, and echo owes evenly to reach water and easily layering of contrast agent (solute), forms hot spot and easily causes shortcomings such as pseudomorphism, thereby influenced its diagnosis effect.And that " heart jade tablet " board stomach window acoustic contrast exists infusion is loaded down with trivial details, and easily the caking deposition forms shortcomings such as hot spot influence diagnosis.
Three, summary of the invention:
In view of the problem of above-mentioned existence, the purpose of this invention is to provide a kind of production has prescription of echo for stomach and intestine acoustic contrast agent and preparation method thereof.That adopts that this prescription and preparation method thereof produces has an echo for stomach and intestine acoustic contrast agent, and granule exquisiteness, simple and convenient, anhydrous, the solute demix of modulation can not form hot spot and cause pseudomorphism, thereby its ultrasonic resolution are high.
Of the present invention to have the echo for stomach and intestine acoustic contrast agent to adopt apple pomace, Semen Maydis powder, Amylum Nelumbinis Rhizomatis be that preparation of raw material forms, and its prescription is (weight ratio %):
Apple pomace: 30%-60%
Semen Maydis powder: 25%-50%
Amylum Nelumbinis Rhizomatis: 5%-20%
Of the present invention a kind ofly have the manufacture method of echo for stomach and intestine acoustic contrast agent to have three kinds, and they are respectively: granular pattern has manufacture method, the powder-type of echo for stomach and intestine acoustic contrast agent that the manufacture method of echo for stomach and intestine acoustic contrast agent and the manufacture method that solvent-borne type has the echo for stomach and intestine acoustic contrast agent are arranged.
1, granular pattern has the technological process of echo for stomach and intestine acoustic contrast agent manufacture method:
After apple pomace, corn after frying or boiling pulverized, adopting micro-nano technology scales that apple pomace, Semen Maydis powder and Amylum Nelumbinis Rhizomatis are processed into the footpath grain is 100 nanometers-15 micron powder, carry out high-temperature sterilization simultaneously, adopt activating technology that it is mixed, granulates then, and pack, promptly make the corpuscular echo for stomach and intestine acoustic contrast agent that has.
2, powder-type has the technological process of echo for stomach and intestine acoustic contrast agent manufacture method:
After apple pomace, corn after frying or boiling pulverized, adopting micro-nano technology scales that apple pomace, Semen Maydis powder and Amylum Nelumbinis Rhizomatis are processed into the footpath grain is 100 nanometers-15 micron powder, carry out high-temperature sterilization simultaneously, and adopt activating technology that it is mixed, weight standard (50 gram/bags, 100 gram/bags) is packed in accordance with regulations then, and that promptly makes powder-type has an echo for stomach and intestine acoustic contrast agent.
3, solvent-borne type has the technological process of echo for stomach and intestine acoustic contrast agent manufacture method:
With the apple pomace after frying or boiling, after corn is pulverized, adopt micro-nano technology scales with apple pomace, it is 100 nanometers-15 micron powder that Semen Maydis powder and Amylum Nelumbinis Rhizomatis are processed into the footpath grain, carry out high-temperature sterilization simultaneously, and adopt activating technology that it is mixed, the powder-type that is made into the echo for stomach and intestine acoustic contrast agent arranged, then, by part (50 a gram/bag) the echo for stomach and intestine acoustic contrast agent that has of powder-type is inserted in the container, and add 500 milliliters aqueous solution, it is stirred, after sterilization and aseptic process, encapsulate, promptly make the solvent type echo for stomach and intestine acoustic contrast agent that has.
The granular pattern that adopts above-mentioned raw materials prescription and manufacture method to produce has echo for stomach and intestine acoustic contrast agent and powder-type that the echo for stomach and intestine acoustic contrast agent is arranged, modulate with boiled water and to take, can not cause water, solute demix after entering gastrointestinal, also can not form hot spot and cause pseudomorphism, thereby its ultrasonic resolution is high; And adopting above-mentioned raw materials prescription and manufacture method to make the solvent type echo for stomach and intestine acoustic contrast agent that has, mouthfeel is good, can directly take, and through clinical use, can not cause side effect to gastrointestinal, thereby is a kind of very good contrast medium for stomach and intestine ultrasonic imaging.
Four, the specific embodiment:
Embodiment one: granular pattern has the preparation of echo for stomach and intestine acoustic contrast agent
In proportion, get apple pomace 25g, corn 20g, Amylum Nelumbinis Rhizomatis 5g, apple pomace, corn are fried or boil, after pulverizing, adopting micro-nano technology that apple pomace, Semen Maydis powder and Amylum Nelumbinis Rhizomatis are carried out ultra-fine grinding, attrition process, to become the footpath grain be 100 nanometers-15 micron powder, carry out high-temperature sterilization simultaneously, adopt activating technology that it is mixed, granulates then, and pack, promptly make the corpuscular echo for stomach and intestine acoustic contrast agent that has.
During use, have the echo for stomach and intestine acoustic contrast agent to be modulated into pasty state granular pattern with boiled water, take to carrying out gastro intestinal ultrasonic radiography person, show that through clinical B ultrasonic image effect is splendid, contrast is also very clear.
Embodiment two: powder-type has the preparation of echo for stomach and intestine acoustic contrast agent
In proportion, get apple pomace 25g, corn 20g, Amylum Nelumbinis Rhizomatis 5g, apple pomace, corn are fried or boil, after pulverizing, adopting micro-nano technology that apple pomace, Semen Maydis powder and Amylum Nelumbinis Rhizomatis are carried out ultra-fine grinding, attrition process, to become the footpath grain be 100 nanometers-15 micron powder, carry out high-temperature sterilization simultaneously, adopt activating technology that it is mixed then, weight standard (50 gram/bags, 100 gram/bags) is packed in accordance with regulations then, and that promptly makes powder-type has an echo for stomach and intestine acoustic contrast agent.
During use, have the echo for stomach and intestine acoustic contrast agent to be modulated into pasty state powder-type with boiled water, take to carrying out gastro intestinal ultrasonic radiography person, show that through clinical B ultrasonic image effect is splendid, contrast is also very clear.
Embodiment three: solvent-borne type has the preparation of echo for stomach and intestine acoustic contrast agent
In proportion, get apple pomace 25g, corn 20g, Amylum Nelumbinis Rhizomatis 5g, with apple pomace, corn fries or boils, after pulverizing, adopt micro-nano technology with apple pomace, Semen Maydis powder and Amylum Nelumbinis Rhizomatis carry out ultra-fine grinding, it is 100 nanometers-15 micron powder that attrition process becomes the footpath grain, carry out high-temperature sterilization simultaneously, and adopt activating technology that it is mixed, the powder-type that is made into the echo for stomach and intestine acoustic contrast agent arranged, then, by part (50 a gram/bag) the echo for stomach and intestine acoustic contrast agent that has of powder-type is inserted in the container, and add 500 milliliters aqueous solution, it is stirred, after sterilization and aseptic process, encapsulate, promptly make the solvent type echo for stomach and intestine acoustic contrast agent that has.
It is very easy that solvent-borne type has the echo for stomach and intestine acoustic contrast agent to take.During use, opening solvent-borne type has sealing of the molten device of echo for stomach and intestine acoustic contrast agent, can take to carrying out gastro intestinal ultrasonic radiography person.After taking, show that through clinical B ultrasonic image effect is splendid, contrast is also very clear.
Claims (5)
1, a kind of have echo for stomach and intestine acoustic contrast agent and preparation method thereof, it is characterized in that this has the echo for stomach and intestine acoustic contrast agent to adopt apple pomace, Semen Maydis powder, Amylum Nelumbinis Rhizomatis is that preparation of raw material forms, and its prescription is (weight ratio %):
Apple pomace: 30%-60%
Semen Maydis powder: 25%-50%
Amylum Nelumbinis Rhizomatis: 5%-20%
2, a kind of echo for stomach and intestine acoustic contrast agent and preparation method thereof that has according to claim 1, it is characterized in that this manufacture method has three kinds, they are respectively: the manufacture method that granular pattern has the manufacture method of echo for stomach and intestine acoustic contrast agent or manufacture method that powder-type has the echo for stomach and intestine acoustic contrast agent or solvent-borne type that the echo for stomach and intestine acoustic contrast agent is arranged.
3, a kind of echo for stomach and intestine acoustic contrast agent and preparation method thereof that has according to claim 1 is characterized in that described granular pattern has the technological process of the manufacture method of echo for stomach and intestine acoustic contrast agent to be:
After apple pomace, corn after frying or boiling pulverized, adopting micro-nano technology scales that apple pomace, Semen Maydis powder and Amylum Nelumbinis Rhizomatis are processed into the footpath grain is 100 nanometers-15 micron powder, carry out high-temperature sterilization simultaneously, adopt activating technology that it is mixed, granulates then, and pack, promptly make the corpuscular echo for stomach and intestine acoustic contrast agent that has.
4, a kind of echo for stomach and intestine acoustic contrast agent and preparation method thereof that has according to claim 1 is characterized in that described powder-type has the technological process of the manufacture method of echo for stomach and intestine acoustic contrast agent to be:
After apple pomace, corn after frying or boiling pulverized, adopting micro-nano technology scales that apple pomace, Semen Maydis powder and Amylum Nelumbinis Rhizomatis are processed into the footpath grain is 100 nanometers-15 micron powder, carry out high-temperature sterilization simultaneously, and adopt activating technology that it is mixed, weight standard (50 gram/bags, 100 gram/bags) is packed in accordance with regulations then, and that promptly makes powder-type has an echo for stomach and intestine acoustic contrast agent.
5, a kind of echo for stomach and intestine acoustic contrast agent and preparation method thereof that has according to claim 1 is characterized in that described solvent-borne type has the technological process of the manufacture method of echo for stomach and intestine acoustic contrast agent to be:
With the apple pomace after frying or boiling, after corn is pulverized, adopt micro-nano technology scales with apple pomace, it is 100 nanometers-15 micron powder that Semen Maydis powder and Amylum Nelumbinis Rhizomatis are processed into the footpath grain, carry out high-temperature sterilization simultaneously, and adopt activating technology that it is mixed, the powder-type that is made into the echo for stomach and intestine acoustic contrast agent arranged, then, by part (50 a gram/bag) the echo for stomach and intestine acoustic contrast agent that has of powder-type is inserted in the container, and add 500 milliliters aqueous solution, it is stirred, after sterilization and aseptic process, encapsulate, promptly make the solvent type echo for stomach and intestine acoustic contrast agent that has.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510050197 CN1721000A (en) | 2005-06-22 | 2005-06-22 | Gastrointestinal ultrasonic contrast medium with echo and its preparation process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510050197 CN1721000A (en) | 2005-06-22 | 2005-06-22 | Gastrointestinal ultrasonic contrast medium with echo and its preparation process |
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| CN1721000A true CN1721000A (en) | 2006-01-18 |
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| CN 200510050197 Pending CN1721000A (en) | 2005-06-22 | 2005-06-22 | Gastrointestinal ultrasonic contrast medium with echo and its preparation process |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110251694A (en) * | 2019-07-15 | 2019-09-20 | 陕西中医药大学 | A kind of contrast medium for stomach and intestine ultrasonic imaging and preparation method thereof |
| CN111265676A (en) * | 2020-03-02 | 2020-06-12 | 吉林大学 | Gastrointestinal ultrasonic contrast agent and preparation method thereof |
| DE102023125436A1 (en) | 2022-10-12 | 2024-04-18 | Shandong Branden Medical Device Co., Ltd. | Development agents for gastrointestinal sonography and manufacturing processes thereof |
| DE102023125435A1 (en) | 2022-10-13 | 2024-04-18 | Shandong Branden Medical Device Co., Ltd. | Two-component auxiliary winding agent for gastric sonography and manufacturing process thereof |
-
2005
- 2005-06-22 CN CN 200510050197 patent/CN1721000A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110251694A (en) * | 2019-07-15 | 2019-09-20 | 陕西中医药大学 | A kind of contrast medium for stomach and intestine ultrasonic imaging and preparation method thereof |
| CN110251694B (en) * | 2019-07-15 | 2022-08-12 | 陕西中医药大学 | Gastrointestinal ultrasonic contrast agent and preparation method thereof |
| CN111265676A (en) * | 2020-03-02 | 2020-06-12 | 吉林大学 | Gastrointestinal ultrasonic contrast agent and preparation method thereof |
| DE102023125436A1 (en) | 2022-10-12 | 2024-04-18 | Shandong Branden Medical Device Co., Ltd. | Development agents for gastrointestinal sonography and manufacturing processes thereof |
| DE102023125435A1 (en) | 2022-10-13 | 2024-04-18 | Shandong Branden Medical Device Co., Ltd. | Two-component auxiliary winding agent for gastric sonography and manufacturing process thereof |
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