CN110251630A - 一种藏药巴桑浓缩片剂及其制备方法 - Google Patents
一种藏药巴桑浓缩片剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种藏药巴桑浓缩片剂及其制备方法,该片剂由以下药材和辅料制成:主药方:诃子、毛诃子、余甘子、黄精、天冬、迷果芹、喜马拉雅紫茉莉和蒺藜,辅助方:刺柏、烈香杜鹃花、水柏枝和大籽蒿,咔擦尔方和辅料:藏糖、蜂蜜、冰糖、酥油和犏牛奶,本发明的片剂采用浓缩工艺,辅料相对减少,使得黄精、天冬、迷果芹等主药方有效成分增加且作用更大,特别是辅料的减少使药丸或药片的油腻性减少,容易消化,适用人群范围更广。
Description
技术领域
本发明属于藏医药领域,具体涉及一种藏药巴桑浓缩片剂及其制备方法。
背景技术
巴萨酥油丸,始载于藏医经典古籍《四部医典》中,已有1300年的应用历史。具有有病治病,无病保健的作用,在藏药传统方剂中具有重要的地位和价值,深受养生保健人群和中老年人患者的青睐。
巴萨酥油丸的处方中主药方由黄精、天冬、迷果芹、喜马拉雅紫茉莉、蒺藜,再加辅方药和咔擦尔方药等,共有31种药材进行分类加工,其中含有如冬虫夏草、红参、雪蛙等贵稀藏药材。主要用于心悸失眠、脾胃不和、老年虚弱、经络不利、肢体僵硬、免疫力低下、肾虚、阳痿不举、虚损不足等症。具有良好的药效和保健作用。
巴桑酥油丸配方较多,主要以加减药味不同而配制,因而本方的配方和药效也显然不同。该方组方合理、疗效确切、易于成型的最佳配方,更适用于青中老年人都使用,在诸多藏医药古籍文献中都以秘诀内容加以记载,在藏医药界临床上使用几百年,疗效确切。
本发明人在传统藏药剂型巴桑酥油丸的生产和临床使用中发现诸多需要改进的问题。第一、原剂型巴萨酥油丸生产过程中由于原料药种类较多,导致工艺复杂,生产周期长。第二、原处方主要以酥油制丸,酥油量多不适用于年轻人及赤巴型人服用,容易引起胆囊类和消化不良等方面的疾病。第三、原处方中蜂蜜和白砂糖、藏糖的量比较多,糖分含量高,不适用于心脑血管疾病、糖尿病、肥胖者等服用。
基于传统巴桑酥油丸存在较多缺点,本发明人通过探索和研究,将原有传统剂型“巴萨酥油丸”进行减少含糖量、减加酥油,采用超微粉碎、真空干燥等现代制药设备和技术,将巴桑酥油丸开发为巴桑浓缩片剂,制定其最佳制备工艺方法;简化工艺、提高疗效。使其更好的发挥药效,为传统藏药开拓了更广泛的使用范围和使用方法,为人们的健康服务做出更大的。
发明内容
本发明的目的在于提供了一种藏药巴桑浓缩片剂及其制备方法。
在一实施方案中,本发明的藏药巴桑浓缩片剂,由以下重量份的主药方、辅方、咔擦尔方和辅料制成,所述主药方由诃子7-10份、毛诃子7-10份、余甘子7-10份、黄精7-10份、天冬6-10份、迷果芹6-10份、喜马拉雅紫茉莉0.006-0.01份、蒺藜6-10份组成,所述辅方由刺柏0.5-3份、烈香杜鹃花3-7份、水柏枝1-4份、大籽蒿0.5-3份组成,所述咔擦尔方由红参1-2份、冬虫夏草0.050-0.200份、雪蛙1-2只、手参0.5-2份、寒水石0.2-0.5份、草寇0.3-0.8份、渣驯膏0.5-0.8份昂纳赛保0.2-0.6份、荜拨0.2-0.6份、石榴皮0.2-0.7份组成,其中所述雪蛙1-2只按红参1-2份计,所述辅料由藏糖5-15份、蜂蜜10-20份、冰糖10-15份、酥油5-15份、犏牛奶50-90份组成。
优选的,本发明的巴桑浓缩片剂,所述主药方由诃子9.2份、毛诃子9.2份、余甘子9.2份、黄精9.2份、天冬8.2份、迷果芹8.2份、喜马拉雅紫茉莉0.0082份和蒺藜8.2份(重量份)组成,所述辅方由刺柏2.0份、烈香杜鹃花5份、水柏枝2.5份、大籽蒿2份(重量份)组成,所述咔擦尔方由红参1.5份、冬虫夏草0.12份、雪蛙1只、手参1.2份、寒水石0.35份、草寇0.5份、渣驯膏0.7份、昂纳赛保0.4份、荜拨0.4份、石榴皮0.45份组成,其中所述雪蛙1只按红参1.5份计,所述辅料由藏糖10份、蜂蜜15份、冰糖12份、酥油10份、犏牛奶70份组成。
在另一实施方案中,本发明提供一种上述本发明的藏药巴桑浓缩片剂的方法,包括以下步骤:
1)将主药方的药材加入6-10倍量(重量倍)水,第一次提取0.8-1.5h后,过滤,收集滤液,滤渣再加5-7倍量水,第二次提取0.5-1小时,过滤,除去滤渣,收集滤液,合并两次提取滤液;
2)将辅方的药材加6-10倍量水,第一次提取0.8-1.5h后,过滤,收集滤液,滤渣再加5-7倍量水,第二次提取0.5-1小时,过滤,除去滤渣,收集滤液,合并两次提取滤液。
3)将咔擦尔方药材粉碎成药粉,过120目筛;
4)步骤1)的主药方提取滤液和辅方的提取滤液混合,加入牛奶和少量酥油进行浓缩,浓缩至密度为1.3以上后再加入步骤3)的咔擦尔方药粉,进行搅拌混匀,对浸膏进行真空干燥(干燥温度不高于80℃)、粉碎、过筛;
5)将辅料蜂密、冰糖、藏糖粉末与上步的浸膏粉进行混合、搅拌均匀,制软材,制粒、整粒,干燥,过筛、压片即得。
优选的,本发明所述的方法,步骤1)中,所述第一次提取,加水量为主药方的药材总重量的8倍,提取时间为1小时,所述第二次提取,加水量为主药方的药材总重量的6倍,提取时间为45分钟;步骤2)中,所述第一次提取,加水量为辅方的药材总重量的8倍,提取时间为1小时,所述第二次提取,加水量为辅方的药材总重量的6倍,提取时间为45分钟。
本发明在传统巴桑酥油丸基础上,通过开发最佳新配方、改剂型(片剂)和生产工艺方法,并解决了以下的技术问题:
1)研究出组方合理、疗效确切、易于成型的最佳配方。
2)研究和开发出巴萨浓缩片的最佳制备工艺流程。
3)解决了传统巴桑酥油丸在心脑血管疾病、糖尿病、肥胖者等人群的使用受限的问题。
4)解决原有传统巴桑酥油丸剂型不易包装、不易存贮的问题,提升原有剂型的口感。
5)采用现代工艺技术,为传统藏药剂型开拓了新的方法,有利简化工艺、提高疗效。
6)对部分难以粉碎和混合的药材,采用了现代提取浸膏的方式,更加提高了疗效。
7)与原酥油丸相比,酥油减量和白糖、藏糖、蜂蜜各减少3分之2。
附图说明
图1为藏药巴桑浓缩片剂生产工艺流程图。
具体实施方式
以下实施例仅是代表性的具体实施方案,用于理解和阐明本发明的精神实质,但不以此限制本发明的范围。
实施例1巴桑浓缩片剂
处方如下:
主药方:诃子9.2kg、毛诃子9.2kg、余甘子9.2kg、黄精9.2kg、天冬8.2kg、迷果芹8.2kg、喜马拉雅紫茉莉0.0082kg和蒺藜8.2kg
辅方:由刺柏2.0kg、烈香杜鹃花5kg、水柏枝2.5kg、大籽蒿2kg
咔擦尔方:由红参1.5kg、冬虫夏草0.12kg、雪蛙1只、手参1.2kg、寒水石0.35kg、草寇0.5kg、渣驯膏0.7kg、昂纳赛保0.4kg、荜拨0.4kg、石榴皮0.45kg组成,
辅料:藏糖10kg、蜂蜜15kg、冰糖12kg、酥油10kg、犏牛奶70kg。
制备工艺如下:
1)主药方药材:诃子、毛诃子、余甘子、黄精、天冬、迷果芹、喜马拉雅紫茉莉、蒺藜等8种药材进行拣选干净,称量。
2)辅方药材:刺柏、烈香杜鹃、麻黄、大籽蒿等药材进行拣选干净,称量。
3)咔擦尔方药材:红参、冬虫夏草、雪蛙、手参、寒水石、草寇、渣驯膏、昂纳赛保、荜拨、石榴皮等贵稀藏药材进行拣选、称量、粉碎、过筛120目筛,得到咔擦尔方药粉。
4)辅料:犏牛奶,酥油,蜂密(炼制)、藏糖、冰糖等5种药材称量备用。
5)将主药方药材加入8倍量(药材总重量)水,第一次煮沸提取1h后,过滤,收集滤液,滤渣再加入6倍量水,第二次煮沸提取45分钟,过滤,去滤渣,收集滤液,合并两次提取滤液混合,得主药方提取液,加热减压浓缩成浸膏,浸膏收率是药材投入量的25%。
6)将辅方药加入8倍量(辅方药材总重量)水,第一次煮提1h,过滤,收集滤液,滤渣再加入6倍量水,第二次煮提45分钟,过滤,去滤渣,收集滤液,合并两次提取滤液混合,得辅方提取液,加热减压浓缩成浸膏,浸膏收率是药材投入量的25%。
7)将上述步骤5)主药方和步骤6)辅方的提取液混合,加牛奶和少量酥油精制浓缩,浓缩液中加入咔擦尔方药粉,进行搅拌,混合均匀,然后进行真空干燥、粉碎、过筛。
8)制片:将辅料中蜂密(炼制)、藏糖、冰糖粉末作为赋形剂与步骤7)的浸膏粉进行多次混合,搅拌均匀,制软材,制粒、整粒,干燥,过筛、压片成浓缩片。
每片重500-1000mg,患者根据不同病因服用3-6片,根据不同的病情,给予一日1-3次,优选一日1次,每次3-6片晚上服用。
实施例2片剂的制备
处方:
主药方:诃子7-10份、毛诃子7-10份、余甘子7-10份、黄精7-10份、天冬6-10份、迷果芹6-10份、喜马拉雅紫茉莉0.006-0.01份、蒺藜6-10份;
辅方由刺柏0.5-3份、烈香杜鹃花3-7份、水柏枝1-4份、大籽蒿0.5-3份;
咔擦尔方:红参1-2份、冬虫夏草0.050-0.200份、雪蛙1-2只、手参0.5-2份、寒水石0.2-0.5份、草寇0.3-0.8份、渣驯膏0.5-0.8份、昂纳赛保0.2-0.6份、荜拨0.2-0.6份、石榴皮0.2-0.7份组成,其中所述雪蛙1-2只按红参1-2份计,
辅料:藏糖5-15份、蜂蜜10-20份、冰糖10-15份、酥油5-15份、犏牛奶50-90份组成。
制备工艺如下:
参照实施例的工艺,分别制备主药方提取液69.6公斤浓缩液,辅方药浓缩液38.9公斤浓缩液,将主药方浓缩液与辅方浓缩液进行混合,加牛奶、少量酥油一起浓缩,浓缩至对密度为1.3以上,向浓缩液加入咔擦尔方药粉,进行搅拌混合,再进行真空干燥(温度低于80℃)、粉碎、再加入藏糖、蜂蜜、冰糖粉搅拌均匀,制软材,制粒、整粒,干燥,过筛、压片成浓缩片。
稳定性实验:按以上工艺配方量配制3批,对处方量、工艺参数进行稳定性工艺验证,经验证各工序的参数可控、稳定、均一。
经临床验证,临床疗效好于或与传统的巴桑酥油丸相当。但剂量减少,具有更好的依从性。
Claims (9)
1.一种藏药巴桑浓缩片剂,由以下重量份的主药方、辅方、咔擦尔方和辅料制成,所述主药方由诃子7-10份、毛诃子7-10份、余甘子7-10份、黄精7-10份、天冬6-10份、迷果芹6-10份、喜马拉雅紫茉莉0.006-0.01份、蒺藜6-10份组成,所述辅方由刺柏0.5-3份、烈香杜鹃花3-7份、水柏枝1-4份、大籽蒿0.5-3份组成,所述咔擦尔方由红参1-2份、冬虫夏草0.050-0.200份、雪蛙1-2只、手参0.5-2份、寒水石0.2-0.5份、草寇0.3-0.8份、渣驯膏0.5-0.8份昂纳赛保0.2-0.6份、荜拨0.2-0.6份、石榴皮0.2-0.7份组成,其中所述雪蛙1-2只按红参1-2份计,所述辅料由藏糖5-15份、蜂蜜10-20份、冰糖10-15份、酥油5-15份、犏牛奶50-90份组成。
2.如权利要求1所述的片剂,所述主药方由诃子9.2份、毛诃子9.2份、余甘子9.2份、黄精9.2份、天冬8.2份、迷果芹8.2份、喜马拉雅紫茉莉0.0082份和蒺藜8.2份组成。
3.如权利要求1所述的片剂,所述辅方由刺柏2.0份、烈香杜鹃花5份、水柏枝2.5份、大籽蒿2份组成。
4.如权利要求1所述的片剂,所述咔擦尔方由红参1.5份、冬虫夏草0.12份、雪蛙1只、手参1.2份、寒水石0.35份、草寇0.5份、渣驯膏0.7份昂纳赛保0.4份、荜拨0.4份、石榴皮0.45份组成,其中所述雪蛙1只按红参1.5份计。
5.如权利要求1所述的片剂,所述辅料由藏糖10份、蜂蜜15份、冰糖12份、酥油10份、犏牛奶70份组成。
6.一种制备权利要求1的藏药巴桑浓缩片剂的方法,包括以下步骤:
1)将主药方的药材加入6-10倍量(重量倍)水,第一次提取0.8-1.5h后,过滤,收集滤液,滤渣再加5-7倍量水,第二次提取0.5-1小时,过滤,除去滤渣,收集滤液,合并两次提取滤液;
2)将辅方的药材加6-10倍量水,第一次提取0.8-1.5h后,过滤,收集滤液,滤渣再加5-7倍量水,第二次提取0.5-1小时,过滤,除去滤渣,收集滤液,合并两次提取滤液。
3)将咔擦尔方药材粉碎成药粉;
4)步骤1)的主药方提取滤液和步骤2)辅方药的提取滤液混合,加入牛奶和少量酥油进行浓缩,浓缩浸膏中再加入步骤3)的咔擦尔方药粉,进行搅拌混合均匀,对浸膏进行真空干燥、粉碎、过筛;
5)将辅料蜂密、冰糖、藏糖粉末与上步的浸膏粉进行混合、搅拌均匀,制软材,制粒、整粒,干燥,过筛、压片即得。
7.如权利要求5所述的方法,步骤1)中,所述第一次提取,加水量为主药方的药材总重量的8倍,提取时间为1小时,所述第二次提取,加水量为主药方的药材总重量的6倍,提取时间为45分钟。
8.如权利要求5所述的方法,步骤2)中,所述第一次提取,加水量为辅方的药材总重量的8倍,提取时间为1小时,所述第二次提取,加水量为辅方的药材总重量的6倍,提取时间为45分钟。
9.如权利要求5所述的方法,步骤3)中,进一步包括将粉碎的药材过120目。
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111358884A (zh) * | 2020-04-14 | 2020-07-03 | 青海大学 | 一种藏药果佳曼玛的组方及其制备方法 |
CN111821379A (zh) * | 2020-07-17 | 2020-10-27 | 西藏藏医药大学 | 用于提高免疫力的藏药巴桑母酥油丸软胶囊的制备方法 |
CN117679485A (zh) * | 2024-01-30 | 2024-03-12 | 烟台优达生物技术开发有限公司 | 一种葛根肽及其应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1099986A (zh) * | 1994-01-13 | 1995-03-15 | 徐晓东 | 强身浸膏 |
CN1546135A (zh) * | 2003-12-04 | 2004-11-17 | 玲 张 | 鹿精培元胶囊的配方和制备工艺及剂型 |
CN104873565A (zh) * | 2015-06-25 | 2015-09-02 | 青海藏浴生物科技有限公司 | 一种药物的制备方法 |
-
2019
- 2019-07-11 CN CN201910622874.3A patent/CN110251630A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1099986A (zh) * | 1994-01-13 | 1995-03-15 | 徐晓东 | 强身浸膏 |
CN1546135A (zh) * | 2003-12-04 | 2004-11-17 | 玲 张 | 鹿精培元胶囊的配方和制备工艺及剂型 |
CN104873565A (zh) * | 2015-06-25 | 2015-09-02 | 青海藏浴生物科技有限公司 | 一种药物的制备方法 |
Non-Patent Citations (3)
Title |
---|
张实著: "《云南藏医药历史与文化》", 31 October 2007, 云南大学出版社 * |
李瑶卿等主编: "《小病上药店 国家非处方中成药简明手册 修订版》", 31 August 2002, 江西科学技术出版社 * |
桑罗却佩著: "《藏医药选编》", 31 December 1982, 青海人民出版社 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111358884A (zh) * | 2020-04-14 | 2020-07-03 | 青海大学 | 一种藏药果佳曼玛的组方及其制备方法 |
CN111821379A (zh) * | 2020-07-17 | 2020-10-27 | 西藏藏医药大学 | 用于提高免疫力的藏药巴桑母酥油丸软胶囊的制备方法 |
CN117679485A (zh) * | 2024-01-30 | 2024-03-12 | 烟台优达生物技术开发有限公司 | 一种葛根肽及其应用 |
CN117679485B (zh) * | 2024-01-30 | 2024-05-10 | 烟台优达生物技术开发有限公司 | 一种葛根肽及其应用 |
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