CN104873565A - 一种药物的制备方法 - Google Patents

一种药物的制备方法 Download PDF

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CN104873565A
CN104873565A CN201510359742.8A CN201510359742A CN104873565A CN 104873565 A CN104873565 A CN 104873565A CN 201510359742 A CN201510359742 A CN 201510359742A CN 104873565 A CN104873565 A CN 104873565A
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索南仁青
卡洛
杨成龙
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Qinghai Tibetan Bath Bio Tech Ltd
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Priority to PCT/CN2016/086533 priority patent/WO2016206575A1/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

本发明涉及药物制备技术领域，尤其是药物的制备方法，包括步骤：分别取100份的刺柏、烈香杜鹃、大籽蒿混合后粉碎成药粉；将100份麻黄、100份水柏枝粉碎后加水煎煮、过滤获得浓缩液；将所述浓缩液与所述药粉搅拌均匀，灭菌后获得成品药物。本发明工艺简单、制作方便，成本低廉。制备获得的药物具有发汗，消炎，止痛，平黄水，活血通络的作用。用于治疗痹病即风湿性关节炎、类风湿性关节炎、痛风等症具有优异效果。

Description

一种药物的制备方法
技术领域
本发明涉及一种药物的组分及其制备技术。
背景技术
患有风湿性关节炎、类风湿性关节炎、痛风等病症的人们日夜遭受病痛煎熬，人们期待开发一种快速有效治疗该病症、且方便易用的药物。
发明内容
为减轻患病人们的痛苦，本发明提供一种药物的制备方法，分别取100份的刺柏、烈香杜鹃、大籽蒿混合后粉碎成药粉；将100份麻黄、100份水柏枝粉碎后加水煎煮1～2小时后过滤，获得浓缩液；将所述浓缩液与所述药粉搅拌均匀，灭菌后获得成品药物。
进一步地，所述药粉还通过孔径不大于100目筛子进行筛选。
进一步地，所述麻黄、水柏枝的质量和与水的质量比为1：6～8。
有益效果：
本发明工艺简单、制作方便，成本低廉。制备获得的药物具有发汗，消炎，止痛，平黄水，活血通络的作用。用于治疗痹病即风湿性关节炎、类风湿性关节炎、痛风等症具有优异效果。
附图说明
图1为本发明实施例的制作流程图。
具体实施方式
下面将结合附图对本发明实施例作详细说明。
藏药“五味甘露贴”由刺柏、烈香杜鹃、大籽蒿、麻黄、水柏枝五味单药组成，其中刺柏作用为补肾；烈香杜鹃作用为清热消肿，补肾；藏大籽蒿作用为清热解毒，散肿止血，利肾；麻黄作用为发汗解表，宣肺平喘，利水；水柏枝作用为清热解毒，发散透疹。
因此，五味甘露贴具有发汗，消炎，止痛，平黄水，活血通络的作用。用于治疗痹病即风湿性关节炎、类风湿性关节炎、痛风等症，并具有显著的疗效。本发明通过反复实验对其生产工艺及质量标准进行了研究，进一步加强了生产过程中的中间体及产品的质量控制，提高了制剂的质量。
本发明药物的制备方法，包括如下步骤，如图1所示：
净选处方五味药材刺柏、烈香杜鹃、大籽蒿、麻黄、水柏枝在不高于50℃的温度进行干燥，然后分别取100份的刺柏、烈香杜鹃、大籽蒿混合后粉碎成药粉，所述药粉通过孔径不大于100目筛子进行筛选，备用。
另行将100份麻黄、100份水柏枝粉碎，加入水煎煮获得浓缩液。其中，麻黄和水柏枝总质量与水的质量比为1：6～8。例如，第一次煎煮加入8倍分量的水煎煮2小时；第二次煎煮加入6倍分量的水煎煮1小时，最后合并两次煎煮后过滤获得的药液，获得所述浓缩液。将所述浓缩液与所述药粉搅拌均匀，在灭菌室辐射灭菌后获得成品药物。
最后，抽中间品进行质量检验，检验合格后进行制贴，包装，取成品检验合格，入库。
本实施例还对制得的药物成品的性状、含膏量、赋形性、微生物限量等质量控制的试验资料分析如下：
性状：本品为褐棕色的片状膏；气清香。
鉴别：(1)取本品置显微镜下观察：纤维状下皮细胞易见，木质化或硅质化，多成束，长480～960μm，直径10～16μm；叶表皮细胞多角形或类长圆形，胞壁微弯或平直，直径15～20μm；不定式气孔类圆形或长圆形，直径17～20μm，长约20～29μm，副卫细胞3～5个；木纤维淡黄色，细胞长条形，微木化。
(2)称取本品约5g，捣碎，加乙醚20ml，与浓氨试液2ml，密塞、放置2小时，时时振摇，滤过，残渣用15ml乙醚分3次洗涤，滤过、合并滤液，加稀盐酸试液2滴，摇匀、蒸干、残渣加乙醇2ml使溶解，滤过，滤液作为供试品溶液。另取盐酸麻黄碱对照品，加甲醇制成每1ml含1mg的溶液，作为对照品溶液。照薄层色谱法(附录57页)试验，吸取上述两种溶疲各5μl，分别点于同一硅胶G薄层板上，以氯仿-甲醇-浓氨试液(20：5：0.5)为展开剂，展开，取出，晾干，喷以茚三酮试液，在105℃烘约10分钟。供试品色谱中，在与对照品色谱相应的位置上，显相同的颜色斑点。
含膏量：按《中华人民共和国卫生部药品标准》检测，取供试品10片，精密称定，撕开内衬除去膏体，再精密称定盖衬和背衬，将得出的重量在之前测定的重量中减去，剩下的重量记为含膏量，标示含膏量范围在1.5g以上至6g的含膏量差异限度为±7％，结果：符合规定。
赋形性：按照《中国药典》2010年版一部(附录II)贴膏项下的赋形性方法检查，取供试品1片，置37℃，相对湿度64％的恒湿恒温箱中30分钟，取出，用夹子将供试品固定在一平整钢板上，钢板与水平面的倾斜角为60°，放置24小时，膏面应无流淌现象。结果：符合规定。
微生物限度：按《中国药典》2010年版一部(附录XIIIC)微生物限度检查法，因含药材原料，微生物限度标准，细菌数每1克不得超过l0000cfu，霉菌和酵母菌每克不得超过l00cfu，大肠埃希菌不得检出，大肠菌群每克小于100个。金黄色葡萄球菌、铜绿假单胞菌每1g不得检出，供样品检验结果：低于限度指数，符合规定。
将制得的药物样品用成品包装后，在室温下，相对温度75％±5％条件下放置18个月，分别在0月、3月、6月、9月、12月、18月，月末取样检测。在试验期间取样6次，结论：通过对样品进行稳定性研究，结果表明样品在稳定性考察过程中各项结果均符合要求，说明该药品质量稳定，药品包装材料的颜色等外观均没有发生变化。说明本发明制得的药物在18个月内保持稳定。

Claims (3)

1.一种药物的制备方法，其特征在于，分别取100份的刺柏、烈香杜鹃、大籽蒿混合后粉碎成药粉；将100份麻黄、100份水柏枝粉碎后加水煎煮1～2小时后过滤，获得浓缩液；将所述浓缩液与所述药粉搅拌均匀，灭菌后获得成品药物。
2.根据权利要求1所述的药物制备方法，其特征在于，所述药粉还通过孔径不大于100目筛子进行筛选。
3.根据权利要求1所述的药物制备方法，其特征在于，所述麻黄、水柏枝的质量和与水的质量比为1：6～8。
CN201510359742.8A 2015-06-25 2015-06-25 一种药物的制备方法 Pending CN104873565A (zh)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016206575A1 (zh) * 2015-06-25 2016-12-29 朱伯秦 一种药物的制备方法
CN107569533A (zh) * 2017-09-18 2018-01-12 次旺 具有增强骨密度功效的组合物及其应用、制备方法
CN110251630A (zh) * 2019-07-11 2019-09-20 金诃藏药股份有限公司 一种藏药巴桑浓缩片剂及其制备方法
CN113577125A (zh) * 2021-08-27 2021-11-02 西藏藏医药大学 一种具有抗炎作用的五味甘露软膏剂及其制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114306698A (zh) * 2022-01-27 2022-04-12 云南养尊堂生物科技有限公司 一种应用乙醇对中药进行渗透性控制微生物的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1238944A (zh) * 1998-06-11 1999-12-22 西藏宇妥藏药研究所 将天然植物药浴液加工成粉状药的方法
CN1660051A (zh) * 2005-01-21 2005-08-31 西藏宇妥藏药研究有限公司 一种藏药浴散剂的制备方法及其质量控制方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1813861A (zh) * 2005-11-29 2006-08-09 久美彭措 五味药浴颗粒
CN104873565A (zh) * 2015-06-25 2015-09-02 青海藏浴生物科技有限公司 一种药物的制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1238944A (zh) * 1998-06-11 1999-12-22 西藏宇妥藏药研究所 将天然植物药浴液加工成粉状药的方法
CN1660051A (zh) * 2005-01-21 2005-08-31 西藏宇妥藏药研究有限公司 一种藏药浴散剂的制备方法及其质量控制方法

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016206575A1 (zh) * 2015-06-25 2016-12-29 朱伯秦 一种药物的制备方法
CN107569533A (zh) * 2017-09-18 2018-01-12 次旺 具有增强骨密度功效的组合物及其应用、制备方法
CN110251630A (zh) * 2019-07-11 2019-09-20 金诃藏药股份有限公司 一种藏药巴桑浓缩片剂及其制备方法
CN113577125A (zh) * 2021-08-27 2021-11-02 西藏藏医药大学 一种具有抗炎作用的五味甘露软膏剂及其制备方法
CN113577125B (zh) * 2021-08-27 2022-03-15 西藏藏医药大学 一种具有抗炎作用的五味甘露软膏剂及其制备方法

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