CN110237159A - A kind of Medical cold application and preparation method thereof - Google Patents
A kind of Medical cold application and preparation method thereof Download PDFInfo
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- CN110237159A CN110237159A CN201910612971.4A CN201910612971A CN110237159A CN 110237159 A CN110237159 A CN 110237159A CN 201910612971 A CN201910612971 A CN 201910612971A CN 110237159 A CN110237159 A CN 110237159A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0203—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
- A61F2007/0215—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor containing liquids other than water
- A61F2007/0219—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention belongs to field of medical article technology, it is applied more particularly to a kind of Medical cold, including several cold compress patch monomers and connection strap, cold compress patch monomer and connection strap are structure as a whole, it is separated using connection strap between every two adjacent cold compress patch monomer, strip-shaped hole is uniformly provided on connection strap, cold compress patch monomer successively includes back sheet, gel layer and coating from top to bottom.The present invention passes through the component of optimization gel layer and the proportion of each component, gel layer good permeability obtained, it is nonirritant, without sensitization, it can take off repeatedly and pull and stick, it can also make skin moisturizing moisturizing, skin aging is prevented, meanwhile, it is strong with the compatibility of skin, it is also beneficial to Drug Percutaneous Absorption, wherein, drug ingedient is mainly derived from the Chinese herbal medicine extract, and each raw material coordinates compatibility in the Chinese herbal medicine extract, mutual gain, play the role of activating blood circulation and dispersing blood clots jointly, remove obstruction in channels to relieve pain, good effect is rapid-action, cure rate is high, and nontoxic, without side-effects.
Description
Technical field
The invention belongs to field of medical article technology, and in particular to a kind of Medical cold application and preparation method thereof.
Background technique
Medical cold application is improved according to traditional cold compress mode, and the TDDS prepared based on high-molecular gel is new
Type drug delivery system is core, is made of back sheet, gel layer, adherent layer.Pass through contained humidity in high-molecular gel and day
Heat is taken away in the vaporization of right cooling ingredient, can achieve partial cooling, drug ingedient therein is combined with hydrogel, passes through water
Cooperation is used, and drug ingedient can be made to readily penetrate through fat deposit, be penetrated into subcutaneous tissue, and go directly lesions position, is acted on affected part, is reached
To the effect of cold compress pain relieving, percutaneous absorbtion, sustained-release administration.Medical cold application can be such that local capillary shrinks, and mitigate part and fill
Blood can make the sensibility of nerve endings reduce and mitigate pain, and cooling is brought down a fever, and regional flow can be reduced, and prevents inflammation and suppuration
Diffusion.Cold compress is suitable for the tissue damage of early stage local software, hyperpyretic patient and heatstroke person, toothache etc. and needs cold compress crowd.
Such as application No. is the patents of CN201811327045.4 to disclose a kind of Medical cold application and preparation method thereof, described
Medical cold application, including back sheet, medicine layer and adherent layer, medicine layer are made of traditional Chinese medicinal components and auxiliary material, and traditional Chinese medicinal components include:
Ground bettle, vomiting nut, Southern Star, tuber of pinellia etc.；Auxiliary material includes: carbomer part, Sodium Polyacrylate part, glycerol part, purifying moisture content.The hair
Bright Medical cold application has effects that activating microcirculation and removing stasis medicinal, swelling and pain relieving, clearing damp eliminating impediment, be mainly used for various neck-shoulder pain, lumbago and leg pains,
The closed soft tissue injuries such as disc herniation, sciatica, rheumatic arthritis, traumatic injury and the treatment ached, still
The Medical cold application water conservation performance of keeping humidity of the invention is undesirable, easily stimulates skin output after sticking, and the compatibility with skin
Difference is unfavorable for Drug Percutaneous Absorption.
Summary of the invention
The purpose of the present invention is being directed to existing issue, a kind of Medical cold application and preparation method thereof is provided.
The present invention is achieved by the following technical solutions: a kind of Medical cold application, including several cold compress patch monomers and
Connection strap, which is characterized in that the cold compress patch monomer and the connection strap are structure as a whole, every two adjacent cold compress patch monomer
Between be separated using the connection strap, strip-shaped hole is uniformly provided on the connection strap, the cold compress patch monomer is by upper
It include successively down back sheet, gel layer and coating, the raw material of the gel layer includes: carbomer 25~40 by weight
Part, 6~8 parts of Sodium Polyacrylate, 3~5 parts of ethyl alcohol, 2~4 parts of moisturizer, 4~7 parts of transdermal enhancer, the Chinese herbal medicine extract 15~20
Part, 60~80 parts of purified water；
Wherein, the moisturizer is compounded by Sodium Hyaluronate and decyl glucoside according to mass ratio 3:2；The transdermal enhancer
By N- acetyl proline amylalcohol ester and menthol according to mass ratio (1~2): 5 compound.
As further improvement of these options, the preparation process of the Chinese herbal medicine extract are as follows:
(1) Chinese medicine material of following parts by weight: 6~8 parts of the rhizome of davallia, 3~5 parts of Radix Notoginseng, 4~6 parts of vomiting nut, safflower 3 is weighed
~5 parts, 2~4 parts of ground bettle, 2~4 parts of Baeckea frutescens L., 2~3 parts of the root of Dahurain angelica, 1~2 part of ramulus mori, after above-mentioned Chinese medicine material is cleaned up
It is placed in 20~30min of sterilization processing in ultraviolet disinfection tank to take out, under sterile working, being crushed to partial size is 3mm hereinafter, setting appearance again
The water that 5~8 times of weight is uniformly mixed and added in device, obtains mixed material；
(2) to said mixture material row Microwave Extraction, Microwave Extraction 460~520W of power, Extracting temperature is 45~48 DEG C, the time
For 40~60min, it is 200~300W that power is used while Microwave Extraction, and the ultrasonic wave that frequency is 30~35KHz carries out auxiliary
Ultrasonic extraction is helped, the complex enzyme that 0.8~1.2wt% is then added into mixed material at 40~45 DEG C is digested, and carbon is used
It is 7.0~7.5 that sour hydrogen sodium, which adjusts pH value, and constant temperature is kept to digest 2~3h；
(3) after digesting, then the ethyl alcohol of 0.5~0.8 times of weight of mixed material is added, control temperature to 55~68 DEG C of holdings 2
~4h, filtering, obtains the first filtrate；The water of 1~3 times of weight of filter residue, control temperature to 65~75 DEG C of 1~3h of holding, mistake are added again
Filter obtains the second filtrate, merges the filtrate extracted twice, is concentrated after being cooled to room temperature, and recycles ethyl alcohol to get Chinese herbal medicine is arrived
Extracting solution.
As further improvement of these options, step (2) is compound in the preparation process of the Chinese herbal medicine extract
Enzyme is to be mixed by cellulase, phytase and protease according to mass ratio 1:1:2.
As further improvement of these options, the concentration of step (3) in the preparation process of the Chinese herbal medicine extract
The volume ratio of front and back is 4:1.
As further improvement of these options, the back sheet is non-woven fabrics or compound nonwoven cloth, the coating
For any one in film layer, layer of polypropylene foil, polycarbonate film layer.
As further improvement of these options, a kind of preparation method of Medical cold application, comprising the following steps:
(1) raw material required for gel layer is weighed respectively, it is spare；
(2) carbomer and Sodium Polyacrylate are dissolved in a part of purified water, impregnate 30~40min of swelling under normal temperature conditions,
Then the stirring rate of 100~150r/min stirs 10~20min, after stirring and evenly mixing, as component one；
(3) ethyl alcohol, moisturizer and transdermal enhancer are added in the purified water of remainder, with 150~200r/min under normal temperature condition
Stirring rate stir 20~30min, after stirring and evenly mixing, as component two；
(4) by component one, component two after 40~50 DEG C of 10 min of water-bath, then by component one and the Chinese herbal medicine extract
It is added together into component two, then 30~50min is stirred with the stirring rate of 150~200r/min, after stirring and evenly mixing, coagulated
Glue；
(5) punching is carried out continuously to connection strap upper surface using punch machines, then gel is spread evenly across each cold compress patch list
On the back sheet of body, upper caldding layer is pressed, cured, packaging can obtain Medical cold application.
The mechanism of action of the invention is: carbomer is a kind of third be crosslinked with pentaerythrite etc. with acrylic acid in raw material
Olefin(e) acid crosslinked resin is a kind of outstanding gel-type vehicle, there is the important uses such as thickening, suspension, and Sodium Polyacrylate has extremely strong
Thicken water retaining function, product purity is high, performance is extremely stable, odorless, tasteless, deposit long it is not corrupt, to select carbomer and poly- third
Olefin(e) acid sodium has preferable affinity collectively as carrier base material, to skin, and good permeability can be taken off repeatedly and pull and stick, and
Can long duration of action in affected part；Moisturizer is compounded by Sodium Hyaluronate and decyl glucoside, and the two mutually cooperates with energy
It effectively prevent gel layer to harden, also gel layer moisture evaporation can be prevented too fast, improve moistening effect, wherein quality is lesser
Bright matter acid sodium can also penetrate into skin epidermis, promote the supply of skin-nourishing and the excretion of waste, moreover it is possible to which playing prevents skin old
The effect of change, decyl glucoside surface tension is low, wetting power is strong, nontoxic to skin, harmless, and can also reduce gel layer and match
The irritation of side；Transdermal enhancer is compounded by N- acetyl proline amylalcohol ester and menthol, wherein N- acetyl proline amylalcohol
Ester is artificial synthesized transdermal enhancer, and transdermal enhancer is natural transdermal enhancer, and compounding between the two can significantly improve drug ingedient and infiltrate through
The ability of skin can also reduce the usage amount of transdermal enhancer, reduce unnecessary toxic side effect, in addition, menthol can also
Play local antipruritic, only sick and refrigerant and slight local anaesthesia effect.
The raw material of the Chinese herbal medicine extract chooses the rhizome of davallia, Radix Notoginseng, vomiting nut, safflower, ground bettle, Baeckea frutescens L., the root of Dahurain angelica and mulberry
Branch, in which:
The rhizome of davallia-meridian distribution of property and flavor: bitter, temperature.Return kidney, Liver Channel.Major function: The strong bone of kidney tonifying, continues and hinders pain relieving.For lumbago due to the kidney deficiency,
Hiccough and deaf, tooth mobility, falling winks frustrates, injured bone；Control outward alopecia areata, leucoderma.
Radix Notoginseng-meridian distribution of property and flavor: temperature, sweet, slight bitter；Return liver, stomach meridian；Major function: dissipating stasis and stanching bleeding, detumescence ding-tong.For spitting blood, spit
Blood, bleeding from five sense organs or subcutaneous tissue, hematochezia, metrorrhagia and metrostaxis, traumatic hemorrhage, chest and abdomen shouting pain, tumbling and swelling.
Vomiting nut-meridian distribution of property and flavor: temperature, it is bitter；Return liver, the spleen channel；Big poison；Major function: remove obstruction in channels to relieve pain, mass dissipating and swelling eliminating.For
Rheumatoid arthritis stubborn paralysis and numbness, injury from falling down, ulcer sore pain；Sequelae of infantile paralysis, rheumatoid arthritis.
Safflower-meridian distribution of property and flavor: taste sweet and neutral enters the heart, Liver Channel.Major function: there is activating microcirculation and removing stasis medicinal, the function of Yu Kaijie is dissipated,
Troubled thoughts pent-up is controlled, chest diaphragm ruffian is bored, spits blood, and typhoid fever is gone mad, and shies and is afraid of in a trance, women's menostasis, postpartum blood stasis abdominal pain, tumbling and swelling.
Ground bettle-meridian distribution of property and flavor: it is cold, it is salty；Return liver warp；Mild toxicity；Major function: broken stasis of blood blood, continuous muscles and bones.It is rolled over for muscles and bones
Wound, blood stasis closed, miasma lump in the abdomen lump in the abdomen.
Baeckea frutescens L.-meridian distribution of property and flavor: it is bitter in taste, it trembles with fear, it is nontoxic.Major function: there are stasis eliminatings, relieve pain, diuresis, the function of desinsection is controlled
Traumatic injury, rheumatalgia, stranguria syndrome, scabies, the ringworm of the foot.
The root of Dahurain angelica-meridian distribution of property and flavor: warm-natured, acrid flavour.Return stomach meridian, large intestine channel, lung channel.Major function: relieve heat dehumidifying, it is sensible only
Bitterly, detumescence and apocenosis.Belong to the warm-pungent diaphoretic drug of diaphoretic medicine subordinate classification.
Ramulus mori-meridian distribution of property and flavor: slight bitter；It is mild-natured.Enter Liver Channel.Major function: wind-damp dispelling, sharp joint, row aqueous vapor.It is wet to control chill
Numbness, spasm of limbs, beriberi edema, human body pruritus.
Above-mentioned all medicines coordinate compatibility, and mutual gain is played the role of activating blood circulation and dispersing blood clots jointly, remove obstruction in channels to relieve pain, good effect, work
Fastly, cure rate is high, and nontoxic, without side-effects, the present invention can be used for pain caused by treating closed soft tissue injury, swelling and
The symptoms such as numbness.
Compared with prior art, the present invention passes through the component of optimization gel layer and the proportion of each component, gel layer obtained
Good permeability, it is nonirritant, without sensitization, can take off repeatedly and pull and stick, moreover it is possible to make skin moisturizing moisturizing, prevent skin aging,
Meanwhile it is strong with the compatibility of skin, it is also beneficial to Drug Percutaneous Absorption, wherein drug ingedient is mainly derived from Chinese herbal medicine extraction
Liquid can play the role of activating blood circulation and dispersing blood clots, remove obstruction in channels to relieve pain, and good effect is rapid-action, and cure rate is high.In the preparation of the Chinese herbal medicine extract
In the process, it is extracted using microwave and assisting ultrasonic, is then digested using complex enzyme, will not only be destroyed in product
Natural sex ingredient, moreover it is possible to promote the effective component in Chinese medicine to be fully dissolved out, easy to operate, time saving and energy saving, extraction efficiency is high；?
When preparing gel with the Chinese herbal medicine extract, the matrix carbomer of gel need to maintain in just have consistency to alkalescent, so can not be with
Acids skin-active composition is simultaneously deposited, therefore plant acid in Chinese herbal medicine is neutralized using sodium bicarbonate, and extracting solution is made to keep mild alkaline conditions.Separately
Outside, preparation method of the invention is at low cost, and high production efficiency is suitable for large-scale promotion application.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
Needed for having in technical description；Attached drawing to be used is briefly described.It should be evident that the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
It obtains other drawings based on these drawings.
Fig. 1 is structural schematic diagram of the invention；
Fig. 2 is the schematic cross-section of cold compress patch monomer in the present invention.
Wherein, 1- cold compress patch monomer, 101- back sheet, 102- gel layer, 103- coating, 2- connection strap, 3- strip-shaped hole.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention,
Technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is the present invention one
Divide embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not making
Every other embodiment obtained, shall fall within the protection scope of the present invention under the premise of creative work.
As shown in Figs. 1-2, a kind of Medical cold application, including several cold compress patch monomers 1 and connection strap 2, cold compress patch monomer 1
It is structure as a whole, is separated using connection strap 2 between every two adjacent cold compress patch monomer 1, connection strap 2 with connection strap 2
On be uniformly provided with strip-shaped hole 3, the trend of strip-shaped hole 3 be for straight line, such design on the one hand in packaging convenient for pair
Cold compress patch monomer 1 is folded, on the other hand reducing occupied space can determine using cold compress patch monomer 1 according to injured area
Number, it is practical, while cutting operation also very simple, only scissors need to be taken to cut off along the trend of strip-shaped hole 3, cold compress
Paste monomer 1 successively includes back sheet 101, gel layer 102 and coating 103 from top to bottom.
Embodiment 1
A kind of Medical cold application, including several cold compress patch monomers and connection strap, the cold compress patch monomer successively wrap from top to bottom
Back sheet, gel layer and coating are included, the raw material of the gel layer includes: 25 parts of carbomer, Sodium Polyacrylate 6 by weight
Part, 3 parts of ethyl alcohol, 2 parts of moisturizer, 4 parts of transdermal enhancer, 15 parts of the Chinese herbal medicine extract, 60 parts of purified water；
Wherein, the moisturizer is compounded by Sodium Hyaluronate and decyl glucoside according to mass ratio 3:2；The transdermal enhancer
It is compounded by N- acetyl proline amylalcohol ester and menthol according to mass ratio 1:5.
The preparation process of the Chinese herbal medicine extract are as follows:
(1) Chinese medicine material of following parts by weight: 6 parts of the rhizome of davallia, 3 parts of Radix Notoginseng, 4 parts of vomiting nut, 3 parts of safflower, ground bettle 2 is weighed
Part, 3 parts of Baeckea frutescens L., 2 parts of the root of Dahurain angelica, 1 part of ramulus mori, above-mentioned Chinese medicine material is cleaned up and is placed on sterilization processing in ultraviolet disinfection tank
20min takes out, and under sterile working, is crushed to partial size as 3mm and 5 times of weight are uniformly mixed and added in container hereinafter, setting again
Water obtains mixed material；
(2) to said mixture material row Microwave Extraction, Microwave Extraction power 460W, Extracting temperature is 45 DEG C, time 40min,
It is 200W that power is used while Microwave Extraction, and the ultrasonic wave that frequency is 30KHz carries out assisting ultrasonic extraction, then at 40 DEG C
The lower complex enzyme that 0.8wt% is added into mixed material is digested, and wherein complex enzyme is by cellulase, phytase and albumen
Enzyme is mixed according to mass ratio 1:1:2, and adjusting pH value with sodium bicarbonate is 7.0, and constant temperature is kept to digest 2h；
(3) after digesting, then the ethyl alcohol of 0.5 times of weight of mixed material is added, control temperature to 55~68 DEG C of holding 2h, mistake
Filter, obtains the first filtrate；The water of 1 times of weight of filter residue, control temperature to 65 DEG C of holding 1h are added again, and filtering obtains the second filtrate, merges
The filtrate extracted twice is concentrated after being cooled to room temperature, and the volume ratio of the filtrate concentration front and back after merging is 4:1, recycling
Ethyl alcohol to get arrive the Chinese herbal medicine extract.
A kind of preparation method of Medical cold application, comprising the following steps:
(1) raw material required for gel layer is weighed respectively, it is spare；
(2) carbomer and Sodium Polyacrylate are dissolved in a part of purified water, impregnate swelling 30min under normal temperature conditions, then
The stirring rate of 100r/min stirs 10min, after stirring and evenly mixing, as component one；
(3) ethyl alcohol, moisturizer and transdermal enhancer are added in the purified water of remainder, with the stirring of 150r/min under normal temperature condition
Rate stirs 20min, after stirring and evenly mixing, as component two；
(4) component one, component two are then added component one and the Chinese herbal medicine extract after 40 DEG C of water-bath 10min together
Enter into component two, then 30min is stirred with the stirring rate of 150r/min, after stirring and evenly mixing, obtains gel；
(5) punching is carried out continuously to connection strap upper surface using punch machines, then gel is spread evenly across each cold compress patch list
On the back sheet of body, upper caldding layer is pressed, cured, packaging can obtain Medical cold application.
Embodiment 2
A kind of Medical cold application, including several cold compress patch monomers and connection strap, the cold compress patch monomer successively wrap from top to bottom
Back sheet, gel layer and coating are included, the raw material of the gel layer includes: 30 parts of carbomer, Sodium Polyacrylate 7 by weight
Part, 4 parts of ethyl alcohol, 3 parts of moisturizer, 5 parts of transdermal enhancer, 18 parts of the Chinese herbal medicine extract, 70 parts of purified water；
Wherein, the moisturizer is compounded by Sodium Hyaluronate and decyl glucoside according to mass ratio 3:2；The transdermal enhancer
It is compounded by N- acetyl proline amylalcohol ester and menthol according to mass ratio 2:5.
The preparation process of the Chinese herbal medicine extract are as follows:
(1) Chinese medicine material of following parts by weight: 7 parts of the rhizome of davallia, 4 parts of Radix Notoginseng, 5 parts of vomiting nut, 4 parts of safflower, ground bettle 3 is weighed
Part, 3 parts of Baeckea frutescens L., 3 parts of the root of Dahurain angelica, 2 parts of ramulus mori, above-mentioned Chinese medicine material is cleaned up and is placed on sterilization processing in ultraviolet disinfection tank
25min takes out, and under sterile working, is crushed to partial size as 3mm and 6 times of weight are uniformly mixed and added in container hereinafter, setting again
Water obtains mixed material；
(2) to said mixture material row Microwave Extraction, Microwave Extraction power 480W, Extracting temperature is 46 DEG C, time 50min,
It is 250W that power is used while Microwave Extraction, and the ultrasonic wave that frequency is 32KHz carries out assisting ultrasonic extraction, then at 42 DEG C
The lower complex enzyme that 1.0wt% is added into mixed material is digested, and wherein complex enzyme is by cellulase, phytase and albumen
Enzyme is mixed according to mass ratio 1:1:2, and adjusting pH value with sodium bicarbonate is 7.3, and constant temperature is kept to digest 2.5h；
(3) after digesting, then the ethyl alcohol of 0.7 times of weight of mixed material is added, control temperature to 62 DEG C of holding 3h, filtering obtains
First filtrate；The water of 2 times of weight of filter residue, control temperature to 70 DEG C of holding 2h are added again, and filtering obtains the second filtrate, merges twice
The filtrate of extraction is concentrated after being cooled to room temperature, and the volume ratio of filtrate after merging concentration front and back is 4:1, recycling ethyl alcohol,
Obtain the Chinese herbal medicine extract.
A kind of preparation method of Medical cold application, comprising the following steps:
(1) raw material required for gel layer is weighed respectively, it is spare；
(2) carbomer and Sodium Polyacrylate are dissolved in a part of purified water, impregnate swelling 35min under normal temperature conditions, then
The stirring rate of 130r/min stirs 15min, after stirring and evenly mixing, as component one；
(3) ethyl alcohol, moisturizer and transdermal enhancer are added in the purified water of remainder, with the stirring of 170r/min under normal temperature condition
Rate stirs 25min, after stirring and evenly mixing, as component two；
(4) component one, component two are then added component one and the Chinese herbal medicine extract after 45 DEG C of water-bath 10min together
Enter into component two, then 40min is stirred with the stirring rate of 180r/min, after stirring and evenly mixing, obtains gel；
(5) punching is carried out continuously to connection strap upper surface using punch machines, then gel is spread evenly across each cold compress patch list
On the back sheet of body, upper caldding layer is pressed, cured, packaging can obtain Medical cold application.
Embodiment 3
A kind of Medical cold application, including several cold compress patch monomers and connection strap, the cold compress patch monomer successively wrap from top to bottom
Back sheet, gel layer and coating are included, the raw material of the gel layer includes: 40 parts of carbomer, Sodium Polyacrylate 8 by weight
Part, 5 parts of ethyl alcohol, 4 parts of moisturizer, 7 parts of transdermal enhancer, 20 parts of the Chinese herbal medicine extract, 80 parts of purified water；
Wherein, the moisturizer is compounded by Sodium Hyaluronate and decyl glucoside according to mass ratio 3:2；The transdermal enhancer
By N- acetyl proline amylalcohol ester and menthol, according to mass ratio, (2:5 is compounded.
The preparation process of the Chinese herbal medicine extract are as follows:
(1) Chinese medicine material of following parts by weight: 8 parts of the rhizome of davallia, 5 parts of Radix Notoginseng, 6 parts of vomiting nut, 5 parts of safflower, ground bettle 4 is weighed
Part, 4 parts of Baeckea frutescens L., 3 parts of the root of Dahurain angelica, 2 parts of ramulus mori, above-mentioned Chinese medicine material is cleaned up and is placed on sterilization processing in ultraviolet disinfection tank
30min takes out, and under sterile working, is crushed to partial size as 3mm and 8 times of weight are uniformly mixed and added in container hereinafter, setting again
Water obtains mixed material；
(2) to said mixture material row Microwave Extraction, Microwave Extraction power 520W, Extracting temperature is 48 DEG C, time 60min,
It is 300W that power is used while Microwave Extraction, and the ultrasonic wave that frequency is 35KHz carries out assisting ultrasonic extraction, then at 45 DEG C
The lower complex enzyme that 1.2wt% is added into mixed material is digested, and wherein complex enzyme is by cellulase, phytase and albumen
Enzyme is mixed according to mass ratio 1:1:2, and adjusting pH value with sodium bicarbonate is 7.5, and constant temperature is kept to digest 3h；
(3) after digesting, then the ethyl alcohol of 0.8 times of weight of mixed material is added, control temperature to 68 DEG C of holding 4h, filtering obtains
First filtrate；The water of 3 times of weight of filter residue, control temperature to 75 DEG C of holding 3h are added again, and filtering obtains the second filtrate, merges twice
The filtrate of extraction is concentrated after being cooled to room temperature, and the volume ratio of filtrate after merging concentration front and back is 4:1, recycling ethyl alcohol,
Obtain the Chinese herbal medicine extract.
A kind of preparation method of Medical cold application, comprising the following steps:
(1) raw material required for gel layer is weighed respectively, it is spare；
(2) carbomer and Sodium Polyacrylate are dissolved in a part of purified water, impregnate swelling 40min under normal temperature conditions, then
The stirring rate of 150r/min stirs 20min, after stirring and evenly mixing, as component one；
(3) ethyl alcohol, moisturizer and transdermal enhancer are added in the purified water of remainder, with the stirring of 200r/min under normal temperature condition
Rate stirs 30min, after stirring and evenly mixing, as component two；
(4) component one, component two are then added component one and the Chinese herbal medicine extract after 50 DEG C of 10 min of water-bath together
Enter into component two, then 50min is stirred with the stirring rate of 200r/min, after stirring and evenly mixing, obtains gel；
(5) punching is carried out continuously to connection strap upper surface using punch machines, then gel is spread evenly across each cold compress patch list
On the back sheet of body, upper caldding layer is pressed, cured, packaging can obtain Medical cold application.
Comparative example 1
A kind of Medical cold application, compared with Example 2, in the raw material proportioning of gel layer, all Sodium Hyaluronates of moisturizer,
Other compositions and preparation step are all the same in addition to this.
Comparative example 2
A kind of Medical cold application, compared with Example 2, in the raw material proportioning of gel layer, all decyl glucose of moisturizer,
Other compositions and preparation step are all the same in addition to this.
Comparative example 3
Patent No. CN201810966118.8, patent name are a kind of Medical cold application and preparation method thereof.
Experiment 1
Medical cold prepared by embodiment and comparative example 1~3 is applied according to Pharmacopoeia of People's Republic of China standard (version in 2015)
It is tested for the property, test result such as table 1:
Table 1
Experiment 2
To Medical-use cold compress exchange premium row skin irritation test prepared by Examples 1 to 3 and comparative example 1~3, specific experiment step is such as
Under: 120 healthy rabbits are taken, and rabbit is divided into 6 groups, the quantity of each group of rabbit is 20, then to each
Family's rabbit back carries out shaving, and the size of shaving is 3cm × 3cm, respectively in each rabbit shaving bonding partially cold compress after 24 h
Patch, wherein first group of rabbit pastes the product of embodiment 1, second group of rabbit pastes the product of embodiment 2, similarly, third group pair
Answer embodiment 3, the 4th group of corresponding comparative example 1, the 5th group of corresponding comparative example 2, observer after the 6th group of 3,48 h of corresponding comparative example
Rabbit skin stimulate the reaction, test result such as table 2:
Table 2
Experiment 3
Carry out clinical observation on the therapeutic effect experiment, the specific steps are as follows: 30 closed soft tissue injury patients are chosen, first by closed
Pain caused by soft tissue injury, swelling, numbness position, after cleaning is dried, then cold compress patch prepared by the embodiment of the present invention 2
It is pasted on affected part, every note sticks for 24 hours, 5 one courses for the treatment of of patch, as a result, it has been found that cure rate is 93.4%.
To sum up, it can be seen from above three experiment product made from the present embodiment 1~3 it is nonirritant, without sensitization, can be anti-
It takes off again and pulls and stick, moreover it is possible to make skin moisturizing moisturizing, prevents skin aging, meanwhile, it is strong with the compatibility of skin, it is also beneficial to medicine
Object Transdermal absorption, wherein drug ingedient is mainly derived from the Chinese herbal medicine extract, the raw material of the Chinese herbal medicine extract choose the rhizome of davallia,
Radix Notoginseng, vomiting nut, safflower, ground bettle, Baeckea frutescens L., the root of Dahurain angelica and ramulus mori, above-mentioned all medicines coordinate compatibility, and mutual gain is played jointly
The effect activate blood circulation and disperse blood clots, removed obstruction in channels to relieve pain, good effect is rapid-action, and cure rate is high, and nontoxic, without side-effects.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
Invention is explained in detail, those skilled in the art should understand that: it still can be to aforementioned each implementation
Technical solution documented by example is modified or equivalent replacement of some of the technical features；And these modification or
Replacement, the spirit and scope for technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution.
Claims (6)
1. a kind of Medical cold application, including several cold compress patch monomers and connection strap, which is characterized in that the cold compress patch monomer and
The connection strap is structure as a whole, and is separated using the connection strap between every two adjacent cold compress patch monomer, described
It is uniformly provided with strip-shaped hole on connection strap, the cold compress patch monomer successively includes back sheet, gel layer and coating from top to bottom,
The raw material of the gel layer includes: 25~40 parts of carbomer, 6~8 parts of Sodium Polyacrylate, 3~5 parts of ethyl alcohol, protects by weight
2~4 parts of humectant, 4~7 parts of transdermal enhancer, 15~20 parts of the Chinese herbal medicine extract, 60~80 parts of purified water；
Wherein, the moisturizer is compounded by Sodium Hyaluronate and decyl glucoside according to mass ratio 3:2；The transdermal enhancer
By N- acetyl proline amylalcohol ester and menthol according to mass ratio (1~2): 5 compound.
2. a kind of Medical cold application as described in claim 1, which is characterized in that the preparation process of the Chinese herbal medicine extract are as follows:
(1) Chinese medicine material of following parts by weight: 6~8 parts of the rhizome of davallia, 3~5 parts of Radix Notoginseng, 4~6 parts of vomiting nut, safflower 3 is weighed
~5 parts, 2~4 parts of ground bettle, 2~4 parts of Baeckea frutescens L., 2~3 parts of the root of Dahurain angelica, 1~2 part of ramulus mori, after above-mentioned Chinese medicine material is cleaned up
It is placed in 20~30min of sterilization processing in ultraviolet disinfection tank to take out, under sterile working, being crushed to partial size is 3mm hereinafter, setting appearance again
The water that 5~8 times of weight is uniformly mixed and added in device, obtains mixed material；
To said mixture material row Microwave Extraction, Microwave Extraction 460~520W of power, Extracting temperature is 45~48 DEG C, and the time is
40~60min, it is 200~300W that power is used while Microwave Extraction, and frequency is that the ultrasonic wave of 30~35KHz is assisted
Ultrasonic extraction, the complex enzyme that 0.8~1.2wt% is then added into mixed material at 40~45 DEG C are digested, and carbonic acid is used
It is 7.0~7.5 that hydrogen sodium, which adjusts pH value, and constant temperature is kept to digest 2~3h；
(3) after digesting, then the ethyl alcohol of 0.5~0.8 times of weight of mixed material is added, control temperature to 55~68 DEG C of holdings 2
~4h, filtering, obtains the first filtrate；The water of 1~3 times of weight of filter residue, control temperature to 65~75 DEG C of 1~3h of holding, mistake are added again
Filter obtains the second filtrate, merges the filtrate extracted twice, is concentrated after being cooled to room temperature, and recycles ethyl alcohol to get Chinese herbal medicine is arrived
Extracting solution.
3. a kind of Medical cold application as claimed in claim 2, which is characterized in that walked in the preparation process of the Chinese herbal medicine extract
Suddenly the complex enzyme of (2) is to be mixed by cellulase, phytase and protease according to mass ratio 1:1:2.
4. a kind of Medical cold application as claimed in claim 2, which is characterized in that walked in the preparation process of the Chinese herbal medicine extract
Suddenly the volume ratio before and after the concentration of (3) is 4:1.
5. a kind of Medical cold application as described in claim 1, which is characterized in that the back sheet is non-woven fabrics or composite non woven
Cloth, the coating are film layer, layer of polypropylene foil, any one in polycarbonate film layer.
6. a kind of preparation method of Medical cold application as described in claim 1, which comprises the following steps:
(1) raw material required for gel layer is weighed respectively, it is spare；
(2) carbomer and Sodium Polyacrylate are dissolved in a part of purified water, impregnate 30~40min of swelling under normal temperature conditions,
Then the stirring rate of 100~150r/min stirs 10~20min, after stirring and evenly mixing, as component one；
(3) ethyl alcohol, moisturizer and transdermal enhancer are added in the purified water of remainder, with 150~200r/min under normal temperature condition
Stirring rate stir 20~30min, after stirring and evenly mixing, as component two；
(4) by component one, component two after 40~50 DEG C of 10 min of water-bath, then by component one and the Chinese herbal medicine extract
It is added together into component two, then 30~50min is stirred with the stirring rate of 150~200r/min, after stirring and evenly mixing, coagulated
Glue；
(5) punching is carried out continuously to connection strap upper surface using punch machines, then gel is spread evenly across each cold compress patch list
On the back sheet of body, upper caldding layer is pressed, cured, packaging can obtain Medical cold application.
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| CN201910612971.4A CN110237159A (en) | 2019-07-09 | 2019-07-09 | A kind of Medical cold application and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113101045A (en) * | 2021-04-24 | 2021-07-13 | 华中科技大学同济医学院附属协和医院 | Medical ice bag water-insulating sleeve and mounting method thereof |
| CN115287821A (en) * | 2022-07-27 | 2022-11-04 | 泉州蓝凯纺织科技有限公司 | Novel non-woven fabric production process |
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2019
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113101045A (en) * | 2021-04-24 | 2021-07-13 | 华中科技大学同济医学院附属协和医院 | Medical ice bag water-insulating sleeve and mounting method thereof |
| CN115287821A (en) * | 2022-07-27 | 2022-11-04 | 泉州蓝凯纺织科技有限公司 | Novel non-woven fabric production process |
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Application publication date: 20190917 |