CN103211978B - Chinese medicine composition for treating kidney-yang deficiency type aplastic anemia - Google Patents
Chinese medicine composition for treating kidney-yang deficiency type aplastic anemia Download PDFInfo
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Abstract
The invention relates to a Chinese medicine composition for treating kidney-yang deficiency type aplastic anemia. The Chinese medicine composition is prepared by using phellinus torulosus, black soybean, common hawksbeard, Orthosiphon aristatus, cistanche, silverweed cinquefoil root, Semen cuscutae, tea tree root, uniflower swisscentaury root, Oldenlandia diffusa, clove and elk horn. The Chinese medicine composition is clinically used for treating kidney-yang deficiency type aplastic anemia.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine composition, especially relate to a kind of Chinese medicine composition for the treatment of Asthenic-yang Type Aplastic Anemia.
Background technology
Aplastic anemia is a kind of different substantiality disease, is the marrow hematopoiesis function failure because a variety of causes causes, and shows as the anemia illness of pancytopenia.Primary disease clinical manifestation except anemia, hemorrhage except, normal companion infects and heating.Scholar is had to think in recent years, the pathogenesis mainly dysimmunity of chronic aplastic anemia.Modern medicine generally adopts Blood transfusion and western thing therapeutic alliance to Asthenic-yang Type Aplastic Anemia, but untoward reaction is heavier, is difficult to prolonged application.Long-term practice through inventor draws, Chinese medicine is controlled Asthenic-yang Type Aplastic Anemia and had better effect, obtains good effect.
Summary of the invention
The object of the present invention is to provide that a kind of therapeutic effect is good, effective percentage is high, Chinese medicine composition to the treatment Asthenic-yang Type Aplastic Anemia of human non-toxic's side effect.
The object of the present invention is achieved like this, according to Chinese medical theory, utilize the property of medicine of Chinese medicine uniqueness, adopt sword skin tree bacterium, Testa sojae atricolor, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), kidney grass, Herba Cistanches, Radix potentillae anserinae, Semen Cuscutae, Radix Camelliae sinensis, Radix Rhapontici, Herba Hedyotidis Diffusae, Flos Caryophylli, angle of flocking together, according to certain compatibility requirement, pass through and are processed into.
Prepare Chinese medicine composition of the present invention to be made up of following raw material medicaments: sword skin tree bacterium 50-70 part, Testa sojae atricolor 35-50 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 35-45 part, kidney grass 35-45 part, Herba Cistanches 20-30 part, Radix potentillae anserinae 20-30 part, Semen Cuscutae 20-30 part, Radix Camelliae sinensis 10-20 part, Radix Rhapontici 10-20 part, Herba Hedyotidis Diffusae 10-20 part, Flos Caryophylli 10-15 part, angle 5-8 part of flocking together.
Optimum weight part of traditional Chinese medicinal composition raw materials of the present invention is: sword skin tree bacterium 60 parts, Testa sojae atricolor 45 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 40 parts, kidney grass 40 parts, Herba Cistanches 25 parts, Radix potentillae anserinae 25 parts, Semen Cuscutae 25 parts, Radix Camelliae sinensis 15 parts, Radix Rhapontici 15 parts, Herba Hedyotidis Diffusae 15 parts, Flos Caryophylli 12 parts, 6 parts, angle of flocking together.
The pharmacological action of Chinese medicine of the present invention is as follows:
Sword skin tree bacterium: enrich blood.Clinical in anemia.
Testa sojae atricolor: sweet, cool.Return spleen, lung, kidney channel.To nourish blood suppressing the hyperactive liver, removing toxic substances of dispeling the wind.Cure mainly headache, deficiency of YIN dysphoria with smothery sensation, night sweat, migratory arthralgia, noxious dampness, carbuncle skin ulcer, dizzy etc.
Crepis crocea Babc.(C.turczaninowii C.A.Mey.): bitter, sweet, warm.Liver and kidney tonifying, invigorating spleen to remove dampness.Clinical in having a dizzy spell, soreness of the waist and knees, edema, leukorrhagia infantile malnutrition, the diseases such as hypogalactia.
Kidney grass: sweet, warm.Kidney-reinforcing Yang-strengthening, nourish blood tonify deficiency, dehumidifying of regulating the flow of vital energy.For asthenia, eyes is dim-sighted, sexual impotence, seminal emission, painful and swollen testis, anemia, nebulousurine, the diseases such as leucorrhea.
Herba Cistanches: sweet, salty, warm.Return kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, intestine moistening road.Cure mainly kidney yang deficiency, the sexual impotence of asthenia of essence and blood, seminal emission, nebulousurine, lumbago flaccidity of the lower limbs, tinnitus order flower, menstruation is spread out the phase, infertility, dryness of the intestine constipation etc.
Radix potentillae anserinae: sweet, bitter, cold.Return spleen, stomach warp.Fill blood, strengthening the spleen and stomach, promoting the production of body fluid to quench thirst.For diarrhea due to hypofunction of the spleen, anemia after being ill, malnutrition, edema, rheumatic arthralgia etc.
Semen Cuscutae: pungent, sweet, put down, return liver,kidney,spleen warp.The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, Gu tire stopping leak.For soreness of waist and knee joint, seminal emission, sexual impotence, premature ejaculation, sterile, quench one's thirst, stranguria with turbid discharge, the enuresis etc.
Radix Camelliae sinensis: bitter, cool.GUIXIN, kidney channel.Heart tonifying diuresis, promoting blood flow to regulate menstruation, heat-clearing and toxic substances removing.For heart disease, edema, hepatitis, dysmenorrhea, aphtha, the diseases such as herpes zoster.
Radix Rhapontici: bitter, cold.Return stomach, large intestine, Liver Channel.Heat-clearing and toxic substances removing, lactogenesis of invigorating blood circulation.For furuncle toxic swelling, hemorrhoid complicated by anal fistula, scabies prurigo, conjunctival congestion and swelling pain, hyperlipidemia, dysentery, ascarid is stomachache early, rheumatic arthralgia, lumbar sprain and QI divergeny, traumatic injury, the diseases such as lack of lactation after delivery.Herba Hedyotidis Diffusae: sweet, cold.GUIXIN, liver, spleen, large intestine channel.Heat-clearing and toxic substances removing, dampness removing.For dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria etc.
Flos Caryophylli: pungent, warm.Return spleen, stomach, kidney channel.Warming middle-JIAO to send down the adverse QI, dispersing cold for relieving pain, warming the kidney to activate YANG., carbuncle of yin nature cold for gastrofrigid vomiting, coldness and pain in the epigastrium, impotence due to deficiency of the kidney, the acid of waist knee joint etc.
To flock together angle: sweet, warm.Return kidney channel.Warming the kidney to invigorate YANG, adds essence and mends marrow, bone and muscle strengthening, beneficial blood vessels.For insufficiency of kidney-YANG, asthenia damage of essence, soreness of the waist and knees, bones and muscles pain, Blood deficiency etc.
Aplastic anemia, according to its anemia, hemorrhage, asthenia, dizziness, the clinical manifestation such as weak, belongs to motherland's medical science " asthenia ", " deficient " and " blood disorder " category.Injure QI and blood internal organs mainly due to six climate exopathogens, seven emotions, eating and drinking without temperance, exhaustion due to sexual indulgence, evil poison etc., especially have influence on spleen, kidney and bone marrow, its pathogenesis is " with kidney asthenia as the principal aspect ".Therefore Asthenic-yang Type Aplastic Anemia is the obstacle of hemopoietic function, from the understanding of traditional Chinese medical science the kidney generating marrow and dominating bone, based on the kidney invigorating, pay attention to reinforce spleen and kidney together, the treatment that Liver and kidney is ruled together, both meet traditional Chinese medical science traditional theory also have modern science according to.In the present invention, sword skin tree bacterium has nourishing blood function, and be monarch drug, Testa sojae atricolor nourishes blood suppressing the hyperactive liver, removing toxic substances of dispeling the wind, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) liver and kidney tonifying, kidney grass kidney-reinforcing Yang-strengthening, nourish blood tonify deficiency, is ministerial drug, Herba Cistanches kidney-replenishing, benefiting essence-blood, Radix potentillae anserinae fills blood, Semen Cuscutae the kidney invigorating and essence nourishing, Radix Camelliae sinensis promoting blood flow to regulate menstruation, heat-clearing and toxic substances removing, Radix Rhapontici heat-clearing and toxic substances removing, invigorates blood circulation, Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, Flos Caryophylli warming the kidney to activate YANG, angle warming the kidney to activate YANG of flocking together.All medicines share plays warming and recuperating the kidney-YANG, heat-clearing and toxic substances removing altogether, and regulating QI is nourished blood, effect of compensate qi and blood, finds through clinical practice, has unique curative effect to Asthenic-yang Type Aplastic Anemia.
Chinese medicine composition of the present invention was in 2004 to 2009 the routine patients of clinical observation Asthenic-yang Type Aplastic Anemia 47, and clinical report is as follows:
1, physical data
Man 20 example, female 27 example, at 19 ~ 65 years old age, average 35 years old, all meets the diagnostic criteria of Asthenic-yang Type Aplastic Anemia.
2, diagnostic criteria
(1) Western medicine diagnose standard: with reference to " diagnosis of hematological diseases and criterion of therapeutical effect " 3 editions.
1) pancytopenia, reticulocyte reduces.Lymphocyte increases relatively.
2) bone marrow at least 1 position hypoplasia or severe lower (as active proliferation, megalokaryocyte must be had obviously to reduce and lymphocyte increases relatively), bone marrow granule non-hematopoietic cell increases that (person of having ready conditions does bone marrow biopsy, display hemopoietic tissue reduces, and fatty tissue increases).
3) other diseases of pancytopenia is caused except energy, as the pancytopenia of paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome, autoantibody mediation, acute aplastic crisis, myelofibrosis, acute from disorders of blood, malignant histocytosis etc.
(2) TCM syndrome diagnostic criteria: with reference to " new Chinese medicine guideline of clinical investigations " (trying).
Aplastic anemia patient cardiopalmus, dizzy, the whole body is weak, and complexion, lip, fingernail are pale, coldness of the body with chills, and waist knee joint epidemic disease is soft, sexual hypofunction, large loose stool, and how without hemorrhage or slightly hemorrhage, pale tongue, deep-thready pulse or empty large, belongs to Asthenic-yang Type Aplastic Anemia.
4, Therapeutic Method
4.1 prescriptions: sword skin tree bacterium 60g, Testa sojae atricolor 45g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 40g, kidney grass 40g, Herba Cistanches 25g, Radix potentillae anserinae 25g, Semen Cuscutae 25g, Radix Camelliae sinensis 15g, Radix Rhapontici 15g, Herba Hedyotidis Diffusae 15g, Flos Caryophylli 12g, flock together angle 6g.
4.2 methods of preparation and use: said medicine routinely technique makes decoction, every day 1 dose, every day 2 times 25 days was 1 course for the treatment of.5, therapeutic outcome:
5.1 clinical efficacy standards: with reference to " diagnosis of hematological diseases and criterion of therapeutical effect " 3 editions
Cure: anemia, bleeding disappear, and hemoglobin reaches 120g/L (man) or 100g/L (female), and numeration of leukocyte reaches 4 × 10
9/ L, platelet count reaches 80 × 10
9/ L, follows up a case by regular visits to and does not recur for more than 1 year.
Effective: anemia, bleeding disappear, and hemoglobin reaches 120g/L (man) or 100g/L (female), and numeration of leukocyte reaches 3.5 × 10
9about/L, platelet count also has necessarily spends increase, follows up a case by regular visits to 3 months stable disease or continues progressive.
Effective: anemia, bleeding are clearly better, in not blood transfusion situation, hemoglobin comparatively to be treated in first 1 month modal value and is increased more than 30g/L, and maintains 3 months and do not fall.
Invalid: through fully treating, symptom, hemogram do not reach obvious progress.
5.2 results: in 47 routine patients, cure 15 examples (31.9%), effective 17 examples (36.2%), effective 10 examples (21.3%), and invalid 5 examples (10.6%), total effective rate is 89.4%.
6, model case
6.1 grandsons, female, 35 years old.Patient's complexion is greyish white, and the whole body is weak, chronognosis cold extremities, and dizzy, cardiopalmus, has gingival hemorrhage, and extremity are cold, large loose stool, light red tongue, white and thin fur, deep-thready pulse.Routine blood test shows: hemoglobin 63g/L, platelet 25 × 10
9/ L.Bone marrow (ilium) puncture is shown: three is that hypertrophy is bad, meets Asthenic-yang Type Aplastic Anemia bone marrow smear.Take medicine of the present invention, treat 1 course for the treatment of, patient's subjective symptoms takes a turn for the better, the whole body unable comparatively before slightly take a turn for the better, limbs are gradually warm, do, have half congealed thin during stool time dizzy, and tongue arteries and veins is the same, and routine blood test shows: hemoglobin 79g/L, platelet 51 × 10
9/ L.Continue to take 2 courses for the treatment of, patients symptomatic takes a turn for the better, and the whole body is still strong, and anemia comparatively before has clear improvement, without dizzy, receive can, peace of sleeping night, two just adjust, light red tongue, white and thin fur, thready pulse.Routine blood test shows: hemoglobin 107g/L, platelet 83 × 10
9/ L.Recovery from illness, follow up a case by regular visits to 1 year, patient is not recurred.
6.2 money, man, 45 years old.Patient's lusterless complexion, skin mucosa is dispersed in petechia, gingival hemorrhage, dizzy, cardiopalmus, and soreness of the waist and knees is unable, and sexual life is barren, sleeps night and still pacifies, large loose stool, and urine is normal, and tongue is dim red, white and thin fur, thready pulse.Routine blood test shows: hemoglobin 65g/L, platelet 24 × 10
9/ L; Bone marrow examination is shown: grain system, red system hypertrophy are all low, have no megalokaryocyte, meet Asthenic-yang Type Aplastic Anemia bone marrow smear.Take medicine of the present invention, treat 1 course for the treatment of, subjective symptoms takes a turn for the better, anemia comparatively before slightly improve, skin mucosa without petechia, time the whole body weak, dizzy, cardiopalmus situation alleviate, two just adjust, and tongue arteries and veins is the same.Routine blood test shows: hemoglobin 85g/L, platelet 51 × 10
9/ L.Continue to take 3 courses for the treatment of, subjective symptoms is obviously improved, and skin mucosa has no petechia, and the whole body is strong, and without symptoms such as dizziness, soreness of the waist and knees, sexual function improving, peace of sleeping night, two just adjust, light red tongue, white and thin fur, rolling pulse.Routine blood test shows: hemoglobin 123g/L, platelet 85 × 10
9/ L, period non-row treatment of blood transfusion, recovery from illness.Follow up a case by regular visits to 1 year, patient experiences stable disease, do not recur.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, and this embodiment following does not only limit the present invention for illustration of the present invention.
Embodiment 1, a kind of Chinese medicine composition for the treatment of Asthenic-yang Type Aplastic Anemia, be set bacterium 50g, Testa sojae atricolor 35g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 35g, kidney grass 35g, Herba Cistanches 20g, Radix potentillae anserinae 20g, Semen Cuscutae 20g, Radix Camelliae sinensis 10g, Radix Rhapontici 10g, Herba Hedyotidis Diffusae 10g by sword skin, Flos Caryophylli 10g, the angle 5g that flocks together make.
Embodiment 2, a kind of Chinese medicine composition for the treatment of Asthenic-yang Type Aplastic Anemia, be set bacterium 60g, Testa sojae atricolor 45g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 40g, kidney grass 40g, Herba Cistanches 25g, Radix potentillae anserinae 25g, Semen Cuscutae 25g, Radix Camelliae sinensis 15g, Radix Rhapontici 15g, Herba Hedyotidis Diffusae 15g by sword skin, Flos Caryophylli 12g, the angle 6g that flocks together make.
Embodiment 3, a kind of Chinese medicine composition for the treatment of Asthenic-yang Type Aplastic Anemia, be set bacterium 70g, Testa sojae atricolor 50g, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 45g, kidney grass 45g, Herba Cistanches 30g, Radix potentillae anserinae 30g, Semen Cuscutae 30g, Radix Camelliae sinensis 20g, Radix Rhapontici 20g, Herba Hedyotidis Diffusae 20g by sword skin, Flos Caryophylli 15g, the angle 8g that flocks together make.
Claims (2)
1. treat a Chinese medicine composition for Asthenic-yang Type Aplastic Anemia, it is characterized in that it is made up of following raw material medicaments:
Sword skin tree bacterium 50-70 part, Testa sojae atricolor 35-50 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 35-45 part, kidney grass 35-45 part, Herba Cistanches 20-30 part, Radix potentillae anserinae 20-30 part, Semen Cuscutae 20-30 part, Radix Camelliae sinensis 10-20 part, Radix Rhapontici 10-20 part, Herba Hedyotidis Diffusae 10-20 part, Flos Caryophylli 10-15 part, angle 5-8 part of flocking together.
2. Chinese medicine composition according to claim 1, is characterized in that it is made up of following raw material medicaments:
Sword skin tree bacterium 60 parts, Testa sojae atricolor 45 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 40 parts, kidney grass 40 parts, Herba Cistanches 25 parts, Radix potentillae anserinae 25 parts, Semen Cuscutae 25 parts, Radix Camelliae sinensis 15 parts, Radix Rhapontici 15 parts, Herba Hedyotidis Diffusae 15 parts, Flos Caryophylli 12 parts, 6 parts, angle of flocking together.
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