CN110236973A - 一种改善口干症的组合物及其在口腔护理用品中的应用 - Google Patents
一种改善口干症的组合物及其在口腔护理用品中的应用 Download PDFInfo
- Publication number
- CN110236973A CN110236973A CN201910507107.8A CN201910507107A CN110236973A CN 110236973 A CN110236973 A CN 110236973A CN 201910507107 A CN201910507107 A CN 201910507107A CN 110236973 A CN110236973 A CN 110236973A
- Authority
- CN
- China
- Prior art keywords
- oral care
- care implement
- sodium
- xerostomia
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 206010013781 dry mouth Diseases 0.000 title claims abstract description 38
- 208000005946 Xerostomia Diseases 0.000 title claims abstract description 37
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims abstract description 66
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 229960003237 betaine Drugs 0.000 claims abstract description 34
- 229960003624 creatine Drugs 0.000 claims abstract description 33
- 239000006046 creatine Substances 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- 235000019441 ethanol Nutrition 0.000 claims description 20
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 16
- 229940034610 toothpaste Drugs 0.000 claims description 15
- 239000000606 toothpaste Substances 0.000 claims description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000049 pigment Substances 0.000 claims description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 8
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000011775 sodium fluoride Substances 0.000 claims description 8
- 235000013024 sodium fluoride Nutrition 0.000 claims description 8
- 229960000414 sodium fluoride Drugs 0.000 claims description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 7
- 235000011187 glycerol Nutrition 0.000 claims description 7
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 6
- 239000004909 Moisturizer Substances 0.000 claims description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 235000003599 food sweetener Nutrition 0.000 claims description 6
- 230000006872 improvement Effects 0.000 claims description 6
- 230000001333 moisturizer Effects 0.000 claims description 6
- 239000003002 pH adjusting agent Substances 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 229940085605 saccharin sodium Drugs 0.000 claims description 6
- 239000000377 silicon dioxide Substances 0.000 claims description 6
- 239000003765 sweetening agent Substances 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 5
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 5
- 235000019634 flavors Nutrition 0.000 claims description 5
- RRLOOYQHUHGIRJ-UHFFFAOYSA-M sodium;ethyl sulfate Chemical compound [Na+].CCOS([O-])(=O)=O RRLOOYQHUHGIRJ-UHFFFAOYSA-M 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- 239000004376 Sucralose Substances 0.000 claims description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- 239000004088 foaming agent Substances 0.000 claims description 4
- 239000003205 fragrance Substances 0.000 claims description 4
- 229940051250 hexylene glycol Drugs 0.000 claims description 4
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 235000019408 sucralose Nutrition 0.000 claims description 4
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 4
- 239000004408 titanium dioxide Substances 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- 239000000811 xylitol Substances 0.000 claims description 4
- 235000010447 xylitol Nutrition 0.000 claims description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 4
- 229960002675 xylitol Drugs 0.000 claims description 4
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 4
- 241000206575 Chondrus crispus Species 0.000 claims description 3
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 claims description 3
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 3
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims description 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 2
- 108010011485 Aspartame Proteins 0.000 claims description 2
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 claims description 2
- 229960000458 allantoin Drugs 0.000 claims description 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 2
- 239000000605 aspartame Substances 0.000 claims description 2
- 235000010357 aspartame Nutrition 0.000 claims description 2
- 229960003438 aspartame Drugs 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 2
- 229930182470 glycoside Natural products 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 230000000474 nursing effect Effects 0.000 claims description 2
- 229960000502 poloxamer Drugs 0.000 claims description 2
- 229920001983 poloxamer Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000001508 potassium citrate Substances 0.000 claims description 2
- 229960002635 potassium citrate Drugs 0.000 claims description 2
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 2
- 235000011082 potassium citrates Nutrition 0.000 claims description 2
- 239000006041 probiotic Substances 0.000 claims description 2
- 235000018291 probiotics Nutrition 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 claims description 2
- 229940083982 sodium phytate Drugs 0.000 claims description 2
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 2
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 claims description 2
- -1 stevioside glycosides Chemical class 0.000 claims description 2
- 239000004575 stone Substances 0.000 claims description 2
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 2
- 239000011592 zinc chloride Substances 0.000 claims description 2
- 235000005074 zinc chloride Nutrition 0.000 claims description 2
- 229960001939 zinc chloride Drugs 0.000 claims description 2
- 239000011746 zinc citrate Substances 0.000 claims description 2
- 229940068475 zinc citrate Drugs 0.000 claims description 2
- 235000006076 zinc citrate Nutrition 0.000 claims description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims 1
- 229940036350 bisabolol Drugs 0.000 claims 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 1
- 235000010333 potassium nitrate Nutrition 0.000 claims 1
- 239000004323 potassium nitrate Substances 0.000 claims 1
- 229940093928 potassium nitrate Drugs 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 claims 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
- 235000010199 sorbic acid Nutrition 0.000 claims 1
- 239000004334 sorbic acid Substances 0.000 claims 1
- 229940075582 sorbic acid Drugs 0.000 claims 1
- 229940013618 stevioside Drugs 0.000 claims 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims 1
- 235000019202 steviosides Nutrition 0.000 claims 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 abstract description 20
- 210000004400 mucous membrane Anatomy 0.000 abstract description 11
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 6
- 201000010099 disease Diseases 0.000 abstract description 5
- 230000003020 moisturizing effect Effects 0.000 abstract description 5
- 230000000638 stimulation Effects 0.000 abstract description 4
- 208000010266 Aggressive Periodontitis Diseases 0.000 abstract description 3
- 208000007565 gingivitis Diseases 0.000 abstract description 3
- 201000006727 periodontosis Diseases 0.000 abstract description 3
- 210000003296 saliva Anatomy 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 238000009472 formulation Methods 0.000 description 5
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 5
- 235000010234 sodium benzoate Nutrition 0.000 description 5
- 239000004299 sodium benzoate Substances 0.000 description 5
- 238000013461 design Methods 0.000 description 4
- 230000001151 other effect Effects 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 230000000675 anti-caries Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000002324 mouth wash Substances 0.000 description 3
- 229940051866 mouthwash Drugs 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 2
- 239000000120 Artificial Saliva Substances 0.000 description 2
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 239000004302 potassium sorbate Substances 0.000 description 2
- 235000010241 potassium sorbate Nutrition 0.000 description 2
- 229940069338 potassium sorbate Drugs 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000002195 soluble material Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 235000021537 Beetroot Nutrition 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 241000790917 Dioxys <bee> Species 0.000 description 1
- 244000147568 Laurus nobilis Species 0.000 description 1
- 235000017858 Laurus nobilis Nutrition 0.000 description 1
- 235000019738 Limestone Nutrition 0.000 description 1
- DMGNFLJBACZMRM-UHFFFAOYSA-N O[P] Chemical compound O[P] DMGNFLJBACZMRM-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- 244000228451 Stevia rebaudiana Species 0.000 description 1
- 235000006092 Stevia rebaudiana Nutrition 0.000 description 1
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- ZHQXROVTUTVPGO-UHFFFAOYSA-N [F].[P] Chemical compound [F].[P] ZHQXROVTUTVPGO-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000003862 amino acid derivatives Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- 208000020670 canker sore Diseases 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000004676 glycans Polymers 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000006028 limestone Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- IRPDISVJRAYFBI-UHFFFAOYSA-N nitric acid;potassium Chemical compound [K].O[N+]([O-])=O IRPDISVJRAYFBI-UHFFFAOYSA-N 0.000 description 1
- HLERILKGMXJNBU-UHFFFAOYSA-N norvaline betaine Chemical compound CCCC(C([O-])=O)[N+](C)(C)C HLERILKGMXJNBU-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 210000004261 periodontium Anatomy 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Birds (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
Abstract
本发明公开了一种改善口干症的组合物及其在口腔护理用品中的应用。所述改善口干症的组合物包括肌酸和甜菜碱;其在口腔护理用品中的质量百分比:肌酸0.1%‑1.4%、甜菜碱0.1%‑5.0%。本发明组合物能够缓解和降低外物对口腔黏膜的刺激、锁水保湿、保护口腔黏膜。本发明添加该组合物的口腔护理用品可以改善口干症,进一步改善口腔其他疾病,如龋齿、牙周病、牙龈炎症等,安全有效,易于在口腔护理用品配方中添加且生产工艺简单。
Description
技术领域
本发明涉及口腔护理技术领域,具体涉及一种改善口干症的口腔护理用品。
背景技术
正常情况下,口腔中唾液的分泌和消耗要达到平衡,即口腔中剩余一定量的唾液,以润滑、保护口腔中的黏膜、牙体和牙周组织。如果口腔中唾液分泌量减少或消耗量增加,则口腔中就会出现唾液分泌和消耗的负平衡,即口干。
口干症临床表现为口唇干裂、舌背干燥,龟裂;口腔黏膜处于炎症充血状态等。唾液缺失会破坏口腔的防御能力,失去唾液滋润的口腔软硬组织更容易遭受治病微生物的侵袭,因此口干患者口腔中最常见的并发症为白色念珠菌病和龋齿。口腔唾液分泌少、口干症患者人群并不少,特别是老人、糖尿病患者等。
专利公开号CN101678217A涉及一种包含橄榄油、三甲基甘氨酸和木糖醇的用于治疗口干燥症以及与其相关的病症的组合物,其在增加非受激性唾液流或减轻口干燥症症状以及改善患者的生活质量方面有非常好的作用。
专利申请公布号CN104955447A涉及一种含牛磺酸、丙二醇和木糖醇的局部口腔组合物,以及用于减轻或消除口干燥的症状和/或预防或治疗口溃疡的用途。
专利申请公布号CN106729656A涉及一种包含中草药提取物和生物酶的治疗口干口腔护理组合物,该口腔护理组合物既能刺激唾液分泌,又包含与唾液中的蛋白或酶相似的组分,能起到人工唾液的作用。
本领域已知减少口腔干燥症的有效成分大多为中草药提取物、多元醇、多糖类组合物或人工唾液等。改善、预防或治疗口干症的口腔护理用品技术比较多,但是市面销售此类产品却非常少。因此开发一款配方简单、易于生产、价格适中、安全有效、可以日常使用的改善口干症的口腔护理用品具有非常好的市场前景。
肌酸天然存在于人体中,是一种氨基酸衍生物。肌酸通过增加细胞能量储备来强化细胞防御机制,使细胞膜免受应激,缓解刺激,起到保护口腔黏膜的作用。肌酸可结合口腔黏膜内的水分,起到锁水保湿的作用,改善口干症。
甜菜碱是源于甜菜根的天然氨基酸衍生物。甜菜碱具有杰出的锁水能力、保湿功效。甜菜碱可以有效降低表面活性剂对皮肤及口腔黏膜的刺激性,能有效缓解口腔干燥症状。
发明内容
发明目的:本发明的目的是为了弥补现有研究技术的不足,提供了一种改善口干症的口腔护理用品,其有效成分为肌酸和甜菜碱。肌酸和甜菜碱能够缓解和降低外物对口腔黏膜的刺激、锁水保湿、保护口腔黏膜,从而改善口干症,进一步改善口腔其他疾病,如龋齿、牙周病、牙龈炎症等。肌酸和甜菜碱均为水溶性原料,安全有效,易于在口腔护理用品配方中添加且生产工艺简单。
技术方案:一种改善口干症的组合物,包括肌酸和甜菜碱。
改善口干症的组合物在口腔护理用品中的质量百分比:肌酸0.1%-1.4%、甜菜碱0.1%-5.0%。
进一步地,改善口干症的组合物在口腔护理用品中的质量百分比:肌酸0.5%-1.4%,甜菜碱2.5%-5.0%。
本发明还公开了上述组合物在口腔护理用品中用于改善口干症的应用。
一种改善口干症的口腔护理用品,所述的口腔护理用品为牙膏,以质量百分比计,包括:肌酸:0.1%-1.4%、甜菜碱:0.1%-5.0%、保湿剂:15.0%-65.0%、摩擦剂:10.0%-50.0%、发泡剂:0.1%-3.0%、增稠剂:0.1%-1.5%、甜味剂:0.01%-0.4%、色素:0%-1.0%、其他活性物:0%-10.0%、pH调节剂:0%-1.0%、防腐剂:0%-1.0%、香精香料:0.1%-1.5%、水:余量。
进一步地,所述的摩擦剂为但不限于二氧化硅、二水合磷酸氢钙、碳酸氢钠中任意一种或至少两种组成;所述的发泡剂为但不限于月桂醇硫酸酯钠、月桂酰肌氨酸钠、椰油酰胺丙基甜菜碱、甲基椰油酰基牛磺酸钠中任意一种或至少两种组成;所述的色素为但不限于二氧化钛、水溶性色素、珠光粉、彩色粒子中任意一种或至少两种组成。
一种改善口干症的口腔护理用品,所述的口腔护理用品为口腔护理液,包括漱口水、口气清新剂和口腔护理啫喱等形式,以质量百分比计,肌酸:0.1%-1.4%、甜菜碱:0.1%-5.0%、保湿剂:5.0%-60.0%、乙醇:0-30.0%、增溶剂:0%-6.0%、增稠剂:0%-2.0%、甜味剂:0%-0.2%、色素:0%-0.1%、其他活性物:0%-6.0%、pH调节剂:0%-1.0%、防腐剂:0%-1.0%、香精香料:0%-1.0%、水:余量。
进一步地,所述的增溶剂为但不限于PEG-40氢化蓖麻油、PEG-60氢化蓖麻油、吐温-20、泊洛沙姆中任意一种或至少两种组成;所述的色素为水溶性色素、油溶性色素中任意一种或至少两种组成。
进一步地,保湿剂为但不限于山梨(糖)醇、甘油、聚乙二醇、丙二醇、木糖醇中的任意一种或至少两种组成;所述的增稠剂为但不限于纤维素胶、羟乙基纤维素、卡拉胶、黄原胶、卡波姆的任意一种或至少两种组成;所述的甜味剂为但不限于糖精钠、三氯蔗糖、甜叶菊苷、阿斯巴甜中的任意一种或至少两种组成;所述的pH调节剂为但不限于柠檬酸、柠檬酸钠、氢氧化钠中的任意一种或至少两种组成;所述的防腐剂为但不限于苯甲酸及其盐类、山梨酸及其盐类、尼泊金酯类及其盐、辛甘醇、己二醇中的任意一种或至少两种组成。
进一步地,其他活性物为但不限于单氟磷酸钠、氟化钠、柠檬酸锌、氯化锌、硝酸钾、柠檬酸钾、植酸钠、三聚磷酸钠、西吡氯铵、羟基磷酸石、尿囊素、益生菌、薁磺酸钠、红没药醇中的任意一种或至少两种组成。
配方中添加的各组分,可以根据口腔护理用品的外观、理化性质和功能设计进行选择性添加。如设计无香配方时,可以不添加香精香料;如设计无色素配方时,可以不添加色素;如设计无乙醇配方时,可以不添加乙醇;如设计一款同时具有改善口干症和预防龋齿的牙膏,可以添加氟化钠或单氟磷酸钠。
口腔护理用品生产制备时,将肌酸和甜菜碱加入水中,溶解均匀即可,其他各组分按照现有生产工艺操作。
本发明的口腔护理用品添加了肌酸和甜菜碱两种水溶性原料,能够缓解和降低外物对口腔黏膜的刺激、锁水保湿、保护口腔黏膜,从而改善口干症,进一步改善口腔其他疾病,如龋齿、牙周病、牙龈炎症等,安全有效,易于在口腔护理用品配方中添加且生产工艺简单。
具体实施方式
下面通过具体实施例对本发明进行说明,但本发明并不局限于此。下述实施例中所述实验方法,如无特殊说明,均为常规方法;所述试剂和材料,如无特殊说明,均可从商业途径获得,下面实施例并非用以限制本发明的专利范围,凡未脱离本发明所为的等效实施或变更,均应包含于本专利保护范围中。
实施例1:
牙膏配方(质量百分比):肌酸:0.5%、甜菜碱:5.0%、山梨(糖)醇:30.0%、聚乙二醇-8:10.0%、二氧化硅:20.0%、月桂醇硫酸酯钠:1.0%、月桂酰肌氨酸钠:2.0%、羟基磷灰石:5.0%、氟化钠:0.32%、纤维素胶:0.3%、黄原胶:0.5%、糖精钠:0.2%、辛甘醇:0.2%,己二醇:0.3%、二氧化钛:0.3%、香精:1.5%、水:22.88%。
牙膏生产工艺:肌酸、甜菜碱、糖精钠和氟化钠在水中溶解均匀,真空反应釜吸入水相溶液、山梨(糖)醇和聚乙二醇-8并搅拌均匀,再吸入二氧化硅、羟基磷灰石、二氧化钛、纤维素胶和黄原胶,真空搅拌均匀,最后加入香精、辛甘醇、己二醇、月桂醇硫酸酯钠和月桂酰肌氨酸钠,搅拌均匀,真空脱泡。
本实施例牙膏添加了肌酸、甜菜碱、羟基磷灰石、氟化钠四种活性物,该牙膏具有改善口干症、预防龋齿、强健牙膏等功效。
实施例2:
牙膏配方(质量百分比):肌酸:0.5%、甜菜碱:2.5%、山梨(糖)醇:12.0%、甘油:12.0%、二水合磷酸氢钙:45.0%、二氧化硅:5.0%、月桂醇硫酸酯钠:1.0%、椰油酰胺丙基甜菜碱:1.5%、黄原胶:1.0%、糖精钠:0.3%、单氟磷酸钠:0.76%、焦磷酸钠:0.5%、二氧化钛:1.0%、尼泊金甲酯:0.1%、尼泊金丙酯:0.1%、香精:1.2%、水:15.54%。
本实施例牙膏生产工艺参照实施例1,本实施例牙膏添加了肌酸、甜菜碱和单氟磷酸钠三种活性物,该牙膏具有改善口干症和预防龋齿等功效。
实施例3:
牙膏配方(质量百分比):肌酸:0.1%、甜菜碱:0.1%、山梨(糖)醇:60.0%、聚乙二醇-8:5.0%、二氧化硅:18.0%、椰油酰胺丙基甜菜碱:2.0%、纤维素胶:0.5%、卡拉胶:0.2%、糖精钠:0.2%、苯甲酸钠:0.5%,珠光粉:0.1%、香精:1.0%、水:12.3%。
本实施例牙膏生产工艺参照实施例1,本实施例牙膏添加了肌酸和甜菜碱两种种活性物,该牙膏具有改善口干症功效。
实施例4:
漱口水配方(质量百分比):肌酸:1.4%、甜菜碱:5.0%、氟化钠:0.05%、甘油:5.0%、乙醇:5.0%、三氯蔗糖:0.05%、西吡氯铵:0.05%、吐温-20:2.0%、PEG-40氢化蓖麻油:4.0%、香精:1.0%、亮蓝:0.0005%、苯甲酸钠:0.5%、水:75.9495%。
漱口水生产工艺:肌酸、甜菜碱、三氯蔗糖、氟化钠、苯甲酸钠、甘油、亮蓝在水中溶解均匀;香精、西吡氯铵、吐温-20、PEG-40氢化蓖麻油和乙醇混合均匀,再与水相溶液搅拌均匀。
本实施例漱口水添加了肌酸、甜菜碱和西吡氯铵,该漱口水具有改善口干症、清新口气、减少口腔细菌等功效。
实施例5:
口腔护理啫喱配方(质量百分比):肌酸:0.5%、甜菜碱:2.5%、山梨(糖)醇:50.0%、甘油:10.0%、纤维素胶:2.0%、苯甲酸钠:0.5%、山梨酸钾:0.5%、水:34.0%。
口腔护理啫喱生产工艺:肌酸、甜菜碱、苯甲酸钠、山梨酸钾和山梨(糖)醇在水中溶解均匀;纤维素胶在甘油中分散均匀,再缓慢加入水相溶液中,并搅拌均匀。
本实施例口腔护理啫喱添加了肌酸和甜菜碱,该口腔护理啫喱具有改善口干症和清新口气等功效。
Claims (10)
1.一种改善口干症的组合物,其特征在于:包括肌酸和甜菜碱。
2.如权利要求1所述的组合物,其特征在于:在口腔护理用品中的质量百分比:肌酸0.1%-1.4%、甜菜碱0.1%-5.0%。
3.如权利要求1所述的组合物,其特征在于:在口腔护理用品中的质量百分比:肌酸0.5%-1.4%,甜菜碱2.5%-5.0%。
4.一种如权利要求1-3中任一项所述的组合物在口腔护理用品中用于改善口干症的应用。
5.一种改善口干症的口腔护理用品,所述的口腔护理用品为牙膏,其特征在于:以质量百分比计,包括:肌酸:0.1%-1.4%、甜菜碱:0.1%-5.0%、保湿剂:15.0%-65.0%、摩擦剂:10.0%-50.0%、发泡剂:0.1%-3.0%、增稠剂:0.1%-1.5%、甜味剂:0.01%-0.4%、色素:0%-1.0%、其他活性物:0%-10.0%、pH调节剂:0%-1.0%、防腐剂:0%-1.0%、香精香料:0.1%-1.5%、水:余量。
6.如权利要求5所述的改善口干症的口腔护理用品,其特征在于:所述的摩擦剂为但不限于二氧化硅、二水合磷酸氢钙、碳酸氢钠中任意一种或至少两种组成;所述的发泡剂为但不限于月桂醇硫酸酯钠、月桂酰肌氨酸钠、椰油酰胺丙基甜菜碱、甲基椰油酰基牛磺酸钠中任意一种或至少两种组成;所述的色素为但不限于二氧化钛、水溶性色素、珠光粉、彩色粒子中任意一种或至少两种组成。
7.一种改善口干症的口腔护理用品,所述的口腔护理用品为口腔护理液,其特征在于:以质量百分比计,肌酸:0.1%-1.4%、甜菜碱:0.1%-5.0%、保湿剂:5.0%-60.0%、乙醇:0-30.0%、增溶剂:0%-6.0%、增稠剂:0%-2.0%、甜味剂:0%-0.2%、色素:0%-0.1%、其他活性物:0%-6.0%、pH调节剂:0%-1.0%、防腐剂:0%-1.0%、香精香料:0%-1.0%、水:余量。
8.如权利要求7所述的改善口干症的口腔护理用品,其特征在于:所述的增溶剂为但不限于PEG-40氢化蓖麻油、PEG-60氢化蓖麻油、吐温-20、泊洛沙姆中任意一种或至少两种组成;所述的色素为水溶性色素、油溶性色素中任意一种或至少两种组成。
9.如权利要求5或7所述的改善口干症的口腔护理用品,其特征在于:保湿剂为但不限于山梨(糖)醇、甘油、聚乙二醇、丙二醇、木糖醇中的任意一种或至少两种组成;所述的增稠剂为但不限于纤维素胶、羟乙基纤维素、卡拉胶、黄原胶、卡波姆的任意一种或至少两种组成;所述的甜味剂为但不限于糖精钠、三氯蔗糖、甜叶菊苷、阿斯巴甜中的任意一种或至少两种组成;所述的pH调节剂为但不限于柠檬酸、柠檬酸钠、氢氧化钠中的任意一种或至少两种组成;所述的防腐剂为但不限于苯甲酸及其盐类、山梨酸及其盐类、尼泊金酯类及其盐、辛甘醇、己二醇中的任意一种或至少两种组成。
10.如权利要求5或7所述的改善口干症的口腔护理用品,其特征在于:所述的其他活性物为但不限于单氟磷酸钠、氟化钠、柠檬酸锌、氯化锌、硝酸钾、柠檬酸钾、植酸钠、三聚磷酸钠、西吡氯铵、羟基磷酸石、尿囊素、益生菌、薁磺酸钠、红没药醇中的任意一种或至少两种组成。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910507107.8A CN110236973A (zh) | 2019-06-12 | 2019-06-12 | 一种改善口干症的组合物及其在口腔护理用品中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910507107.8A CN110236973A (zh) | 2019-06-12 | 2019-06-12 | 一种改善口干症的组合物及其在口腔护理用品中的应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110236973A true CN110236973A (zh) | 2019-09-17 |
Family
ID=67886853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910507107.8A Withdrawn CN110236973A (zh) | 2019-06-12 | 2019-06-12 | 一种改善口干症的组合物及其在口腔护理用品中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110236973A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113995688A (zh) * | 2021-09-29 | 2022-02-01 | 安徽丽润科技有限公司 | 含有椰油酰甲基牛磺酸牛磺酸钠组合物的牙膏 |
-
2019
- 2019-06-12 CN CN201910507107.8A patent/CN110236973A/zh not_active Withdrawn
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113995688A (zh) * | 2021-09-29 | 2022-02-01 | 安徽丽润科技有限公司 | 含有椰油酰甲基牛磺酸牛磺酸钠组合物的牙膏 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR102196459B1 (ko) | 항균 성능이 개선된 치약 조성물 및 이를 포함하는 치약 | |
KR101449453B1 (ko) | 구취제거, 플라그제거 및 항균효과가 우수한 치약 조성물 | |
RU2457829C2 (ru) | Минерально-витаминный комплекс для укрепления эмали зубов, композиция для гигиены полости рта и зубная паста | |
EP3378466A1 (en) | Composition for use in oral cavity | |
JP7417454B2 (ja) | 口腔用組成物 | |
CN110236973A (zh) | 一种改善口干症的组合物及其在口腔护理用品中的应用 | |
RU2362543C1 (ru) | Дентальная липосомальная композиция и зубная паста, включающая указанную липосомальную композицию | |
KR101293893B1 (ko) | 가수분해 실크를 함유하는 구강용 조성물 | |
JPH04182419A (ja) | 口腔用組成物 | |
JP7477291B2 (ja) | 口腔用組成物 | |
EP3217951B1 (en) | Oral care composition | |
JP7417453B2 (ja) | 口腔用組成物 | |
US20050180927A1 (en) | Novel anti-bacterial compositions | |
RU2607931C2 (ru) | Лечебно-профилактическая композиция для ухода за полостью рта гематоонкологических больных | |
EP1716859B1 (de) | Pflanzenextrakte gegen Halitosis, Gingivitis oder Parodontitis | |
AU2017208371B2 (en) | Oral care composition | |
JP2022001557A (ja) | 口腔粘膜炎又は口腔感染症の痛み抑制剤及びこれを含有する口腔用組成物 | |
CN110613631A (zh) | 一种用于口腔护理产品的岩藻多糖清幽抑菌组合物 | |
RU2068688C1 (ru) | Лечебно-профилактическая зубная паста "фортуна" | |
KR20170125752A (ko) | 구강용 조성물 | |
DE68914451T2 (de) | Mundversorgungsmittel. | |
KR20070065955A (ko) | 마이크로캡슐 내에 기능성 원료를 함유한 치약 | |
JPH02264711A (ja) | 歯磨組成物 | |
AU2003213864B2 (en) | Novel anti-bacterial compositions | |
KR20180045614A (ko) | 폴리크레줄렌을 함유하는 구강용 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190917 |
|
WW01 | Invention patent application withdrawn after publication |