CN110236973A - 一种改善口干症的组合物及其在口腔护理用品中的应用 - Google Patents
一种改善口干症的组合物及其在口腔护理用品中的应用 Download PDFInfo
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- CN110236973A CN110236973A CN201910507107.8A CN201910507107A CN110236973A CN 110236973 A CN110236973 A CN 110236973A CN 201910507107 A CN201910507107 A CN 201910507107A CN 110236973 A CN110236973 A CN 110236973A
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- oral care
- care implement
- sodium
- xerostomia
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Abstract
本发明公开了一种改善口干症的组合物及其在口腔护理用品中的应用。所述改善口干症的组合物包括肌酸和甜菜碱；其在口腔护理用品中的质量百分比：肌酸0.1％‑1.4％、甜菜碱0.1％‑5.0％。本发明组合物能够缓解和降低外物对口腔黏膜的刺激、锁水保湿、保护口腔黏膜。本发明添加该组合物的口腔护理用品可以改善口干症，进一步改善口腔其他疾病，如龋齿、牙周病、牙龈炎症等，安全有效，易于在口腔护理用品配方中添加且生产工艺简单。
Description
技术领域
本发明涉及口腔护理技术领域，具体涉及一种改善口干症的口腔护理用品。
背景技术
正常情况下，口腔中唾液的分泌和消耗要达到平衡，即口腔中剩余一定量的唾液，以润滑、保护口腔中的黏膜、牙体和牙周组织。如果口腔中唾液分泌量减少或消耗量增加，则口腔中就会出现唾液分泌和消耗的负平衡，即口干。
口干症临床表现为口唇干裂、舌背干燥，龟裂；口腔黏膜处于炎症充血状态等。唾液缺失会破坏口腔的防御能力，失去唾液滋润的口腔软硬组织更容易遭受治病微生物的侵袭，因此口干患者口腔中最常见的并发症为白色念珠菌病和龋齿。口腔唾液分泌少、口干症患者人群并不少，特别是老人、糖尿病患者等。
专利公开号CN101678217A涉及一种包含橄榄油、三甲基甘氨酸和木糖醇的用于治疗口干燥症以及与其相关的病症的组合物，其在增加非受激性唾液流或减轻口干燥症症状以及改善患者的生活质量方面有非常好的作用。
专利申请公布号CN104955447A涉及一种含牛磺酸、丙二醇和木糖醇的局部口腔组合物，以及用于减轻或消除口干燥的症状和/或预防或治疗口溃疡的用途。
专利申请公布号CN106729656A涉及一种包含中草药提取物和生物酶的治疗口干口腔护理组合物，该口腔护理组合物既能刺激唾液分泌，又包含与唾液中的蛋白或酶相似的组分，能起到人工唾液的作用。
本领域已知减少口腔干燥症的有效成分大多为中草药提取物、多元醇、多糖类组合物或人工唾液等。改善、预防或治疗口干症的口腔护理用品技术比较多，但是市面销售此类产品却非常少。因此开发一款配方简单、易于生产、价格适中、安全有效、可以日常使用的改善口干症的口腔护理用品具有非常好的市场前景。
肌酸天然存在于人体中，是一种氨基酸衍生物。肌酸通过增加细胞能量储备来强化细胞防御机制，使细胞膜免受应激，缓解刺激，起到保护口腔黏膜的作用。肌酸可结合口腔黏膜内的水分，起到锁水保湿的作用，改善口干症。
甜菜碱是源于甜菜根的天然氨基酸衍生物。甜菜碱具有杰出的锁水能力、保湿功效。甜菜碱可以有效降低表面活性剂对皮肤及口腔黏膜的刺激性，能有效缓解口腔干燥症状。
发明内容
发明目的：本发明的目的是为了弥补现有研究技术的不足，提供了一种改善口干症的口腔护理用品，其有效成分为肌酸和甜菜碱。肌酸和甜菜碱能够缓解和降低外物对口腔黏膜的刺激、锁水保湿、保护口腔黏膜，从而改善口干症，进一步改善口腔其他疾病，如龋齿、牙周病、牙龈炎症等。肌酸和甜菜碱均为水溶性原料，安全有效，易于在口腔护理用品配方中添加且生产工艺简单。
技术方案：一种改善口干症的组合物，包括肌酸和甜菜碱。
改善口干症的组合物在口腔护理用品中的质量百分比：肌酸0.1％-1.4％、甜菜碱0.1％-5.0％。
进一步地，改善口干症的组合物在口腔护理用品中的质量百分比：肌酸0.5％-1.4％，甜菜碱2.5％-5.0％。
本发明还公开了上述组合物在口腔护理用品中用于改善口干症的应用。
一种改善口干症的口腔护理用品，所述的口腔护理用品为牙膏，以质量百分比计，包括：肌酸：0.1％-1.4％、甜菜碱：0.1％-5.0％、保湿剂：15.0％-65.0％、摩擦剂：10.0％-50.0％、发泡剂：0.1％-3.0％、增稠剂：0.1％-1.5％、甜味剂：0.01％-0.4％、色素：0％-1.0％、其他活性物：0％-10.0％、pH调节剂：0％-1.0％、防腐剂：0％-1.0％、香精香料：0.1％-1.5％、水：余量。
进一步地，所述的摩擦剂为但不限于二氧化硅、二水合磷酸氢钙、碳酸氢钠中任意一种或至少两种组成；所述的发泡剂为但不限于月桂醇硫酸酯钠、月桂酰肌氨酸钠、椰油酰胺丙基甜菜碱、甲基椰油酰基牛磺酸钠中任意一种或至少两种组成；所述的色素为但不限于二氧化钛、水溶性色素、珠光粉、彩色粒子中任意一种或至少两种组成。
一种改善口干症的口腔护理用品，所述的口腔护理用品为口腔护理液，包括漱口水、口气清新剂和口腔护理啫喱等形式，以质量百分比计，肌酸：0.1％-1.4％、甜菜碱：0.1％-5.0％、保湿剂：5.0％-60.0％、乙醇：0-30.0％、增溶剂：0％-6.0％、增稠剂：0％-2.0％、甜味剂：0％-0.2％、色素：0％-0.1％、其他活性物：0％-6.0％、pH调节剂：0％-1.0％、防腐剂：0％-1.0％、香精香料：0％-1.0％、水：余量。
进一步地，所述的增溶剂为但不限于PEG-40氢化蓖麻油、PEG-60氢化蓖麻油、吐温-20、泊洛沙姆中任意一种或至少两种组成；所述的色素为水溶性色素、油溶性色素中任意一种或至少两种组成。
进一步地，保湿剂为但不限于山梨(糖)醇、甘油、聚乙二醇、丙二醇、木糖醇中的任意一种或至少两种组成；所述的增稠剂为但不限于纤维素胶、羟乙基纤维素、卡拉胶、黄原胶、卡波姆的任意一种或至少两种组成；所述的甜味剂为但不限于糖精钠、三氯蔗糖、甜叶菊苷、阿斯巴甜中的任意一种或至少两种组成；所述的pH调节剂为但不限于柠檬酸、柠檬酸钠、氢氧化钠中的任意一种或至少两种组成；所述的防腐剂为但不限于苯甲酸及其盐类、山梨酸及其盐类、尼泊金酯类及其盐、辛甘醇、己二醇中的任意一种或至少两种组成。
进一步地，其他活性物为但不限于单氟磷酸钠、氟化钠、柠檬酸锌、氯化锌、硝酸钾、柠檬酸钾、植酸钠、三聚磷酸钠、西吡氯铵、羟基磷酸石、尿囊素、益生菌、薁磺酸钠、红没药醇中的任意一种或至少两种组成。
配方中添加的各组分，可以根据口腔护理用品的外观、理化性质和功能设计进行选择性添加。如设计无香配方时，可以不添加香精香料；如设计无色素配方时，可以不添加色素；如设计无乙醇配方时，可以不添加乙醇；如设计一款同时具有改善口干症和预防龋齿的牙膏，可以添加氟化钠或单氟磷酸钠。
口腔护理用品生产制备时，将肌酸和甜菜碱加入水中，溶解均匀即可，其他各组分按照现有生产工艺操作。
本发明的口腔护理用品添加了肌酸和甜菜碱两种水溶性原料，能够缓解和降低外物对口腔黏膜的刺激、锁水保湿、保护口腔黏膜，从而改善口干症，进一步改善口腔其他疾病，如龋齿、牙周病、牙龈炎症等，安全有效，易于在口腔护理用品配方中添加且生产工艺简单。
具体实施方式
下面通过具体实施例对本发明进行说明，但本发明并不局限于此。下述实施例中所述实验方法，如无特殊说明，均为常规方法；所述试剂和材料，如无特殊说明，均可从商业途径获得，下面实施例并非用以限制本发明的专利范围，凡未脱离本发明所为的等效实施或变更，均应包含于本专利保护范围中。
实施例1：
牙膏配方(质量百分比)：肌酸：0.5％、甜菜碱：5.0％、山梨(糖)醇：30.0％、聚乙二醇-8:10.0％、二氧化硅：20.0％、月桂醇硫酸酯钠：1.0％、月桂酰肌氨酸钠：2.0％、羟基磷灰石：5.0％、氟化钠：0.32％、纤维素胶：0.3％、黄原胶：0.5％、糖精钠：0.2％、辛甘醇：0.2％，己二醇：0.3％、二氧化钛：0.3％、香精：1.5％、水：22.88％。
牙膏生产工艺：肌酸、甜菜碱、糖精钠和氟化钠在水中溶解均匀，真空反应釜吸入水相溶液、山梨(糖)醇和聚乙二醇-8并搅拌均匀，再吸入二氧化硅、羟基磷灰石、二氧化钛、纤维素胶和黄原胶，真空搅拌均匀，最后加入香精、辛甘醇、己二醇、月桂醇硫酸酯钠和月桂酰肌氨酸钠，搅拌均匀，真空脱泡。
本实施例牙膏添加了肌酸、甜菜碱、羟基磷灰石、氟化钠四种活性物，该牙膏具有改善口干症、预防龋齿、强健牙膏等功效。
实施例2：
牙膏配方(质量百分比)：肌酸：0.5％、甜菜碱：2.5％、山梨(糖)醇：12.0％、甘油:12.0％、二水合磷酸氢钙：45.0％、二氧化硅：5.0％、月桂醇硫酸酯钠：1.0％、椰油酰胺丙基甜菜碱：1.5％、黄原胶：1.0％、糖精钠：0.3％、单氟磷酸钠：0.76％、焦磷酸钠：0.5％、二氧化钛：1.0％、尼泊金甲酯：0.1％、尼泊金丙酯：0.1％、香精：1.2％、水：15.54％。
本实施例牙膏生产工艺参照实施例1，本实施例牙膏添加了肌酸、甜菜碱和单氟磷酸钠三种活性物，该牙膏具有改善口干症和预防龋齿等功效。
实施例3：
牙膏配方(质量百分比)：肌酸：0.1％、甜菜碱：0.1％、山梨(糖)醇：60.0％、聚乙二醇-8:5.0％、二氧化硅：18.0％、椰油酰胺丙基甜菜碱：2.0％、纤维素胶：0.5％、卡拉胶：0.2％、糖精钠：0.2％、苯甲酸钠：0.5％，珠光粉：0.1％、香精：1.0％、水：12.3％。
本实施例牙膏生产工艺参照实施例1，本实施例牙膏添加了肌酸和甜菜碱两种种活性物，该牙膏具有改善口干症功效。
实施例4：
漱口水配方(质量百分比)：肌酸：1.4％、甜菜碱：5.0％、氟化钠：0.05％、甘油：5.0％、乙醇：5.0％、三氯蔗糖：0.05％、西吡氯铵：0.05％、吐温-20:2.0％、PEG-40氢化蓖麻油：4.0％、香精：1.0％、亮蓝：0.0005％、苯甲酸钠：0.5％、水：75.9495％。
漱口水生产工艺：肌酸、甜菜碱、三氯蔗糖、氟化钠、苯甲酸钠、甘油、亮蓝在水中溶解均匀；香精、西吡氯铵、吐温-20、PEG-40氢化蓖麻油和乙醇混合均匀，再与水相溶液搅拌均匀。
本实施例漱口水添加了肌酸、甜菜碱和西吡氯铵，该漱口水具有改善口干症、清新口气、减少口腔细菌等功效。
实施例5：
口腔护理啫喱配方(质量百分比)：肌酸：0.5％、甜菜碱：2.5％、山梨(糖)醇：50.0％、甘油：10.0％、纤维素胶：2.0％、苯甲酸钠：0.5％、山梨酸钾：0.5％、水：34.0％。
口腔护理啫喱生产工艺：肌酸、甜菜碱、苯甲酸钠、山梨酸钾和山梨(糖)醇在水中溶解均匀；纤维素胶在甘油中分散均匀，再缓慢加入水相溶液中，并搅拌均匀。
本实施例口腔护理啫喱添加了肌酸和甜菜碱，该口腔护理啫喱具有改善口干症和清新口气等功效。
Claims (10)
1.一种改善口干症的组合物，其特征在于：包括肌酸和甜菜碱。
2.如权利要求1所述的组合物，其特征在于：在口腔护理用品中的质量百分比：肌酸0.1％-1.4％、甜菜碱0.1％-5.0％。
3.如权利要求1所述的组合物，其特征在于：在口腔护理用品中的质量百分比：肌酸0.5％-1.4％，甜菜碱2.5％-5.0％。
4.一种如权利要求1-3中任一项所述的组合物在口腔护理用品中用于改善口干症的应用。
5.一种改善口干症的口腔护理用品，所述的口腔护理用品为牙膏，其特征在于：以质量百分比计，包括：肌酸：0.1％-1.4％、甜菜碱：0.1％-5.0％、保湿剂：15.0％-65.0％、摩擦剂：10.0％-50.0％、发泡剂：0.1％-3.0％、增稠剂：0.1％-1.5％、甜味剂：0.01％-0.4％、色素：0％-1.0％、其他活性物：0％-10.0％、pH调节剂：0％-1.0％、防腐剂：0％-1.0％、香精香料：0.1％-1.5％、水：余量。
6.如权利要求5所述的改善口干症的口腔护理用品，其特征在于：所述的摩擦剂为但不限于二氧化硅、二水合磷酸氢钙、碳酸氢钠中任意一种或至少两种组成；所述的发泡剂为但不限于月桂醇硫酸酯钠、月桂酰肌氨酸钠、椰油酰胺丙基甜菜碱、甲基椰油酰基牛磺酸钠中任意一种或至少两种组成；所述的色素为但不限于二氧化钛、水溶性色素、珠光粉、彩色粒子中任意一种或至少两种组成。
7.一种改善口干症的口腔护理用品，所述的口腔护理用品为口腔护理液，其特征在于：以质量百分比计，肌酸：0.1％-1.4％、甜菜碱：0.1％-5.0％、保湿剂：5.0％-60.0％、乙醇：0-30.0％、增溶剂：0％-6.0％、增稠剂：0％-2.0％、甜味剂：0％-0.2％、色素：0％-0.1％、其他活性物：0％-6.0％、pH调节剂：0％-1.0％、防腐剂：0％-1.0％、香精香料：0％-1.0％、水：余量。
8.如权利要求7所述的改善口干症的口腔护理用品，其特征在于：所述的增溶剂为但不限于PEG-40氢化蓖麻油、PEG-60氢化蓖麻油、吐温-20、泊洛沙姆中任意一种或至少两种组成；所述的色素为水溶性色素、油溶性色素中任意一种或至少两种组成。
9.如权利要求5或7所述的改善口干症的口腔护理用品，其特征在于：保湿剂为但不限于山梨(糖)醇、甘油、聚乙二醇、丙二醇、木糖醇中的任意一种或至少两种组成；所述的增稠剂为但不限于纤维素胶、羟乙基纤维素、卡拉胶、黄原胶、卡波姆的任意一种或至少两种组成；所述的甜味剂为但不限于糖精钠、三氯蔗糖、甜叶菊苷、阿斯巴甜中的任意一种或至少两种组成；所述的pH调节剂为但不限于柠檬酸、柠檬酸钠、氢氧化钠中的任意一种或至少两种组成；所述的防腐剂为但不限于苯甲酸及其盐类、山梨酸及其盐类、尼泊金酯类及其盐、辛甘醇、己二醇中的任意一种或至少两种组成。
10.如权利要求5或7所述的改善口干症的口腔护理用品，其特征在于：所述的其他活性物为但不限于单氟磷酸钠、氟化钠、柠檬酸锌、氯化锌、硝酸钾、柠檬酸钾、植酸钠、三聚磷酸钠、西吡氯铵、羟基磷酸石、尿囊素、益生菌、薁磺酸钠、红没药醇中的任意一种或至少两种组成。
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| CN113995688A (zh) * | 2021-09-29 | 2022-02-01 | 安徽丽润科技有限公司 | 含有椰油酰甲基牛磺酸牛磺酸钠组合物的牙膏 |
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| CN113995688A (zh) * | 2021-09-29 | 2022-02-01 | 安徽丽润科技有限公司 | 含有椰油酰甲基牛磺酸牛磺酸钠组合物的牙膏 |
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