CN110229732A - A kind of alcoholic drink mixed with fruit juice and preparation method thereof - Google Patents
A kind of alcoholic drink mixed with fruit juice and preparation method thereof Download PDFInfo
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- CN110229732A CN110229732A CN201910533830.3A CN201910533830A CN110229732A CN 110229732 A CN110229732 A CN 110229732A CN 201910533830 A CN201910533830 A CN 201910533830A CN 110229732 A CN110229732 A CN 110229732A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
- C12G3/05—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs with health-improving ingredients, e.g. flavonoids, flavones, polyphenols or polysaccharides
- C12G3/055—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs with health-improving ingredients, e.g. flavonoids, flavones, polyphenols or polysaccharides extracted from plants
Abstract
The embodiment of the invention discloses a kind of alcoholic drink mixed with fruit juice and preparation method thereof, belong to wine technical field.The alcoholic drink mixed with fruit juice is mixed by wine base and auxiliary material, the wine base is the white wine that alcoholic strength is 50-65 °, and the auxiliary material is made of the medicinal material of following parts by weight: 20-30 parts of pueraria lobata, 20-30 parts of semen coicis, 20-30 parts of semen ziziphi spinosae, 20-30 parts of honeysuckle, 10-15 parts of fructus lycii, 10-15 parts of raspberry, 10-15 parts of hoveniae semoveniae semen, 5-10 parts of hawthorn.The alcoholic drink mixed with fruit juice clear of the embodiment of the present invention, glossy, deposit-free and suspended matter, Chinese medicine perfume (or spice) and aroma are coordinated, aftertaste is long, lingering fragrance assails the nostrils, and alcoholic strength is moderate, and flavour relaxes along coordination, free from extraneous odour, with good organoleptic quality, while also there is the health-care effect of kidney tonifying, restoring consciouness, inducing diaphoresis, protect liver, sleeping, the alcoholic drink mixed with fruit juice health-nutrition, safe and reliable, long-term use is good for health.
Description
Technical field
The present embodiments relate to wine technical fields, and in particular to a kind of alcoholic drink mixed with fruit juice and preparation method thereof.
Background technique
Alcoholic drink mixed with fruit juice is one of assembled alcoholic drinks, also referred to as fragrance of a flower liquid medicine.It is with Spirit, fermented wine or edible alcohol are
Wine base, with edible animals and plants, it is in perfume, flavor, present-color material that food additives, which are used as, is process, changes by certain production technology
The alcoholic drink of former wine base style is become.It is a part of China's tradition spirits culture, has thousands of years of history so far.In the past, by
Living condition developmental limitation is slow, and with the continuous improvement of people's living standards, alcoholic drink mixed with fruit juice is due to its color and has one
Fixed nourishing health function along with the variation of people's consumption demand, thus receives more concerns.
But there are still some problems for the production of alcoholic drink mixed with fruit juice at present, existing alcoholic drink mixed with fruit juice is to promote mouthfeel, often be joined a large amount of
Additive, excessive additive reduces the quality of alcoholic drink mixed with fruit juice, its health effect caused to be deteriorated；Existing alcoholic drink mixed with fruit juice is to material composition
Extraction mainly by alcohol impregnate, raw material availability is not high, leads to the waste of material, while mouthfeel is also not highly desirable.
Since the increase of modern's operating pressure and intensity, especially spirit are for a long time for anxiety, the states such as oppressive, melancholy
Crowd, be easier to occur more women than men, the health of people made to receive great threat.Since ancient times, Chinese traditional treatment root
This principle is more women than men to alleviate based on Yin Yang balancing, adjustment QI-blood circulation, improves people's sub-health state, improves crowd
Quality of life, traditional Chinese medicine theory guidance under, select traditional Chinese medicine through scientific formula, develop with health care function
Alcoholic drink mixed with fruit juice has great importance.
Summary of the invention
For this purpose, the embodiment of the present invention provides a kind of alcoholic drink mixed with fruit juice and preparation method thereof, the alcoholic drink mixed with fruit juice clear is glossy, without heavy
Starch and suspended matter, Chinese medicine perfume (or spice) and aroma are coordinated, and aftertaste is long, and lingering fragrance assails the nostrils, and alcoholic strength is moderate, and flavour relaxes along coordination, are no different
Taste has good organoleptic quality, while also having the health-care effect of kidney tonifying, restoring consciouness, inducing diaphoresis, protect liver, sleeping, alcoholic drink mixed with fruit juice health
Nutrition, safe and reliable, long-term use is good for health.
To achieve the goals above, the embodiment of the present invention provides the following technical solutions:
According to a first aspect of the embodiments of the present invention, the embodiment of the invention provides a kind of alcoholic drink mixed with fruit juice, and the alcoholic drink mixed with fruit juice is by wine base
Be mixed with auxiliary material, the wine base is the white wine that alcoholic strength is 50-65 °, the auxiliary material by following parts by weight medicinal material system
At: 20-30 parts of pueraria lobata, 20-30 parts of semen coicis, 20-30 parts of semen ziziphi spinosae, 20-30 parts of honeysuckle, 10-15 parts of fructus lycii, raspberry
10-15 parts, 10-15 parts of hoveniae semoveniae semen, 5-10 parts of hawthorn.
Further, the auxiliary material is made of the medicinal material of following parts by weight: 25 parts of pueraria lobata, 25 parts of semen coicis, semen ziziphi spinosae
25 parts, 25 parts of honeysuckle, 12 parts of fructus lycii, 12 parts of raspberry, 12 parts of hoveniae semoveniae semen, 8 parts of hawthorn.
According to a second aspect of the embodiments of the present invention, the embodiment of the invention provides a kind of production sides of above-mentioned alcoholic drink mixed with fruit juice
Method the described method comprises the following steps:
1) pueraria lobata, semen coicis, semen ziziphi spinosae, honeysuckle, fructus lycii, raspberry, the hoveniae semoveniae semen, mountain of corresponding parts by weight are weighed
Above-mentioned medicinal material is placed in extractor, adds water to cook by short, bristly hair or beard, the isolated dregs of a decoction and medical fluid, and medical fluid refrigeration is spare；
2) dregs of a decoction for obtaining step 1), which are placed in cylinder, carries out spontaneous fermentation 22-25 days, then adds 2 parts of yellow rice wine, salt 1
Part, 1 part of ginger, 2 parts of vinegar continue fermentation 5-8 days；
3) mixture that step 2) obtains is placed in extractor, and the medical fluid got ready in step 1) is then added to extractor
In, it decocts, filtering obtains extracting solution, and the extracting solution is concentrated under reduced pressure into concentrate；
4) concentrate is added in wine base, mixes, alcoholic drink mixed with fruit juice can be configured to.
Further, in step 1), described the step of adding water to cook are as follows: the water that 6-8 times of medicinal material total weight of addition is measured is in 90-
It is decocted 1-1.5 hours at 100 DEG C.
In step 2), the effect that yellow rice wine, salt, ginger, vinegar is added is to increase the activity of drug, has promoting blood circulationization whirlpool, dissipating bind benefit
The effect of gallbladder, appetizing removing toxic substances.And the dissolubility of active pharmaceutical ingredient is improved, so that extraction efficiency and the utilization rate of raw material increase
Add.
Further, in step 2), fermentation temperature is 30-37 DEG C, and fermentation humidity is 70-80%.
Further, in step 3), the step of the decoction are as follows: 80-100 DEG C decoction 1-1.5 hours.
Further, it in step 3), is filtered using strainer, pore size filter 0.1mm.
Further, in step 3), the extracting solution is concentrated under reduced pressure at being 1.25-1.27 in 60 DEG C of relative densities
Concentrate.
Further, in step 4), in every 500ml wine base, 1ml concentrate is added, alcoholic drink mixed with fruit juice can be configured to.
The effect of each medicinal material in alcoholic drink mixed with fruit juice of the present invention, is described below:
Pueraria lobata: for the dry root of pulse family elegant jessamine or sweet kudzu, Compendium of Material Medica carries that its is cool in nature, gas is flat, sweet in flavor, tool heat-clearing,
Fall fire, toxin expelling effect.Civil brought down a fever with pueraria lobata is promoted the production of body fluid.Pueraria lobata contains 12% flavone compound, such as Puerarin, daizeol
The nutritional ingredients such as glycosides, peanut element are also containing the minerals such as protein, amino acid, sugar and iron needed by human, calcium, copper, selenium
Rare invigorant suitable for people of all ages has the good reputation of " thousand Nian Rencan ".
Semen coicis: the dry mature kernal also known as adlay of gramineae, Semen Coicis etc. are annual or perennial
Herbaceous plant is one of China's integration of drinking and medicinal herbs resource.Compendium of Material Medica records the bright medicine of semen coicis sun, energy invigorating the spleen, beneficial stomach.It is empty then
Its mother is mended, therefore consumptive lung disease pulmonary abscess uses it.The disease of muscles and bones, with Zhi Yangming for this, therefore muscular constricture muscular contracture, wandering arthritis person use it.Native energy unboiled water removes
It is wet, therefore let out dysentery oedema and use it.Modern research shows that: semen coicis has a variety of active ingredients, has antitumor, anti-inflammatory, antipyretic, battle array
Bitterly, the effects of hypoglycemic, induction ovulation and strengthen immunity, edible value with higher.
Semen ziziphi spinosae: the seed of zizyphus phytic acid jujube is a kind of common dual-purpose of drug and food substance.With mental-tranquilization, arrest sweating
Effect, clinic are usually used in palpitation and insomnia, the diseases such as body void hidrosis.The study found that semen ziziphi spinosae contains triterpene and saponin(e, flavonoids, life
The chemical components such as alkaloids, fatty acid have a variety of pharmacological activity such as tranquilizing soporific, anti-arrhythmia, analgesia, anticonvulsion.
Honeysuckle: also known as honeysuckle, belong to Caprifoliaceae.Li Shizhen of the Ming Dynasty is compiled to be spent in Compendium of Material Medica with it and just be opened as white,
Then become the feature of yellow, name honeysuckle, after continue up using so far.Honeysuckle usage history of being used as medicine is long, China
Ancient times are earliest to be expressly recited the effect of Chinese medicine monograph Shennong's Herbal is clearing heat and detoxicating to its, activating microcirculation and removing stasis medicinal.
Fructus lycii: being the ripening fruits of matrimony vine of solanaceae plant, sweet in flavor, mild-natured, return liver, kidney essense, has benefiting shrewd head, yin-nourishing
Moistening lung, qi-restoratives strengthening the essence and other effects.Mainly contain polysaccharides, carotenoid, glycine betaine and other functional ingredient.Modern study table
Bright, polysaccharides has immunological regulation, neuroprotection, anti-oxidant, anti-aging, liver protecting, adjusts the function such as blood lipid, hypoglycemic
Effect.
Raspberry: for rose family rubus plant, have and invigorate the kidney and stop nocturnal emission, is supporing yang and other effects.A large number of studies show that covering basin
Rich in ellagic acid, polysaccharide, anthocyanidin, superoxides, Polyphenols, flavones, Superoxide Dismutase etc. in sub- fruit, have anti-ageing
Always, treatment of urinary tract infections, weight-reducing, anti-cancer and cancer-preventing, cardioprotection, anti-oxidant, reducing blood lipid, it is hypoglycemic, prevent cardiovascular disease
Equal pharmacological actions.
Hoveniae semoveniae semen: being one kind of Rhamnaceae trifoliate orange Dulcis subordinate.Hoveniae semoveniae semen is not only edible can be also used as medicine, and belong to yin-nourishing, promote the production of body fluid, moisten
It is dry, quench the thirst, cool blood class drug, Chinese medicine thinks that it has the effect of reducing fever and causing diuresis, relieving alcoholism, cure mainly wine poison, dysphoria with smothery sensation, it is thirsty, vomiting,
The diseases such as difficulty in urination and defecation.Modern medicine believes that, hoveniae semoveniae semen has the effects of significant diuresis, antitumor, hoveniae semoveniae semen has significant
Liver protection and antialcoholism function.
Hawthorn: for the dry mature fruit of rosaceous plant large-fruited Chinese hawthorn or hawthorn, there is food digesting stomach fortifying, scattered stasis, change
Turbid lipid-loweringing and other effects, while containing triterpene and flavones two major classes chemical component in hawthorn, make it to blood pressure lowering, norcholesterol, relaxes
Opening heart coronary artery has remarkable effect.
The embodiment of the present invention has the advantages that
1, alcoholic drink mixed with fruit juice of the invention is original with pueraria lobata, semen coicis, semen ziziphi spinosae, honeysuckle, fructus lycii, raspberry, hoveniae semoveniae semen, hawthorn
Material is made, wherein pueraria lobata, semen coicis relieving muscles diaphoresis, invigorating vital function and promoting eruption；Fructus lycii, the nourishing liver and kidney of raspberry temperature, qi-restoratives strengthening the essence；Wild jujube
Benevolence, the honeysuckle promoting flow of qi and blood circulation, promoting blood circulation；Hoveniae semoveniae semen reducing fever and causing diuresis, relieving alcoholism；Hawthorn digesting stomach invigorating, scattered stasis.All medicines close
With play kidney-replenishing, yin-nourishing gas, Qiang Jingqi, it is promoting blood circulation and removing obstruction in channels the effect of, manufactured alcoholic drink mixed with fruit juice have preferable kidney tonifying, restoring consciouness, inducing diaphoresis,
Protect liver, sleeping health-care effect.
2, the extraction process that the present invention is combined using water extract method with fermentation method, farthest ensure that in drug
The utilization rate of effective component, extraction efficiency and raw material is high, further by blending the extraction concentrate of medicinal material with wine base
It is prepared, the preparation method simple process, easy to operate, suitable large-scale production.
Specific embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this explanation
Content disclosed by book is understood other advantages and efficacy of the present invention easily, it is clear that described embodiment is the present invention one
Section Example, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not doing
Every other embodiment obtained under the premise of creative work out, shall fall within the protection scope of the present invention.Unless otherwise specified,
" part " in following embodiment and comparative example refers to " parts by weight ".
Embodiment 1
The production method of the alcoholic drink mixed with fruit juice of the present embodiment the following steps are included:
1) weigh 28 parts of pueraria lobata, 20 parts of semen coicis, 26 parts of semen ziziphi spinosae, 30 parts of honeysuckle, 10 parts of fructus lycii, 10 parts of raspberry,
14 parts of hoveniae semoveniae semen, 6 parts of hawthorn, above-mentioned medicinal material is placed in extractor, and the water that 8 times of medicinal material total weight amounts are added decocts at 90 DEG C
1.5 hours, the isolated dregs of a decoction and medical fluid, medical fluid refrigeration were spare；
2) dregs of a decoction for obtaining step 1) are placed in spontaneous fermentation 25 days in cylinder, and fermentation temperature is 35 DEG C, and fermentation humidity is
70%, 2 parts of yellow rice wine, 1 part of salt, 1 part of ginger, 2 parts of vinegar are then added, fermentation 5 days is continued；
3) mixture that step 2) obtains is placed in extractor, and the medical fluid got ready in step 1) is then added to extractor
In, it decocts 1 hour, is filtered using strainer, pore size filter 0.1mm obtains extracting solution, mentions obtained at 90 DEG C
Liquid is taken to be concentrated under reduced pressure into the concentrate for being 1.25 in 60 DEG C of relative densities；
4) in the white wine that every 500ml alcoholic strength is 55 °, 1ml concentrate is added, alcoholic drink mixed with fruit juice can be configured to.
Embodiment 2
The production method of the alcoholic drink mixed with fruit juice of the present embodiment the following steps are included:
1) weigh 25 parts of pueraria lobata, 25 parts of semen coicis, 25 parts of semen ziziphi spinosae, 25 parts of honeysuckle, 12 parts of fructus lycii, 12 parts of raspberry,
12 parts of hoveniae semoveniae semen, 8 parts of hawthorn, above-mentioned medicinal material is placed in extractor, and the water that 6 times of medicinal material total weight amounts are added decocts at 95 DEG C
1 hour, the isolated dregs of a decoction and medical fluid, medical fluid refrigeration were spare；
2) dregs of a decoction for obtaining step 1), which are placed in cylinder, carries out fermentation 22 days, and fermentation temperature is 30 DEG C, and fermentation humidity is
75%, 2 parts of yellow rice wine, 1 part of salt, 1 part of ginger, 2 parts of vinegar are then added, fermentation 8 days is continued；
3) mixture that step 2) obtains is placed in extractor, and the medical fluid got ready in step 1) is then added to extractor
In, it decocts 1.5 hours, is filtered using strainer, pore size filter 0.1mm obtains extracting solution, will be obtained at 85 DEG C
Extracting solution is concentrated under reduced pressure into the concentrate for being 1.25 in 60 DEG C of relative densities；
4) in the white wine that every 500ml alcoholic strength is 50 °, 1ml concentrate is added, alcoholic drink mixed with fruit juice can be configured to.
Embodiment 3
The production method of the alcoholic drink mixed with fruit juice of the present embodiment the following steps are included:
1) weigh 20 parts of pueraria lobata, 25 parts of semen coicis, 24 parts of semen ziziphi spinosae, 20 parts of honeysuckle, 15 parts of fructus lycii, 12 parts of raspberry,
14 parts of hoveniae semoveniae semen, 8 parts of hawthorn, above-mentioned medicinal material is placed in extractor, and the water that 8 times of medicinal material total weight amounts are added is decocted at 100 DEG C
It boils 1 hour, the isolated dregs of a decoction and medical fluid, medical fluid refrigeration is spare；
2) dregs of a decoction for obtaining step 1) are placed in cylinder and ferment 23 days, and fermentation temperature is 37 DEG C, and fermentation humidity is 70%, so
2 parts of yellow rice wine, 1 part of salt, 1 part of ginger, 2 parts of vinegar are added afterwards, continue fermentation 6 days；
3) mixture that step 2) obtains is placed in extractor, and the medical fluid got ready in step 1) is then added to extractor
In, it decocts 1.2 hours, is filtered using strainer, pore size filter 0.1mm obtains extracting solution, will be obtained at 95 DEG C
Extracting solution is concentrated under reduced pressure into the concentrate for being 1.27 in 60 DEG C of relative densities；
4) in the white wine that every 500ml alcoholic strength is 58 °, 1ml concentrate is added, alcoholic drink mixed with fruit juice can be configured to.
Embodiment 4
The production method of the alcoholic drink mixed with fruit juice of the present embodiment the following steps are included:
1) weigh 30 parts of pueraria lobata, 25 parts of semen coicis, 20 parts of semen ziziphi spinosae, 22 parts of honeysuckle, 15 parts of fructus lycii, 10 parts of raspberry,
15 parts of hoveniae semoveniae semen, 5 parts of hawthorn, above-mentioned medicinal material is placed in extractor, and the water that 8 times of medicinal material total weight amounts are added decocts at 90 DEG C
1 hour, the isolated dregs of a decoction and medical fluid, medical fluid refrigeration were spare；
2) dregs of a decoction for obtaining step 1) are placed in cylinder and ferment 25 days, and fermentation temperature is 32 DEG C, and fermentation humidity is 80%, so
2 parts of yellow rice wine, 1 part of salt, 1 part of ginger, 2 parts of vinegar are added afterwards, continue fermentation 8 days；
3) mixture that step 2) obtains is placed in extractor, and the medical fluid got ready in step 1) is then added to extractor
In, it decocts 1.5 hours, is filtered using strainer, pore size filter 0.1mm obtains extracting solution, will be obtained at 80 DEG C
Extracting solution is concentrated under reduced pressure into the concentrate for being 1.25 in 60 DEG C of relative densities；
4) in the white wine that every 500ml alcoholic strength is 62 °, 1ml concentrate is added, alcoholic drink mixed with fruit juice can be configured to.
Embodiment 5
The production method of the alcoholic drink mixed with fruit juice of the present embodiment the following steps are included:
1) weigh 24 parts of pueraria lobata, 30 parts of semen coicis, 30 parts of semen ziziphi spinosae, 28 parts of honeysuckle, 12 parts of fructus lycii, 15 parts of raspberry,
10 parts of hoveniae semoveniae semen, 10 parts of hawthorn, above-mentioned medicinal material is placed in extractor, and the water that 8 times of medicinal material total weight amounts are added is decocted at 95 DEG C
It boils 1.5 hours, the isolated dregs of a decoction and medical fluid, medical fluid refrigeration is spare；
2) dregs of a decoction for obtaining step 1) are placed in cylinder and ferment 25 days, and fermentation temperature is 30 DEG C, and fermentation humidity is 70%, so
2 parts of yellow rice wine, 1 part of salt, 1 part of ginger, 2 parts of vinegar are added afterwards, continue fermentation 5 days；
3) mixture that step 2) obtains is placed in extractor, and the medical fluid got ready in step 1) is then added to extractor
In, it decocts 1.2 hours, is filtered using strainer, pore size filter 0.1mm obtains extracting solution, will be obtained at 90 DEG C
Extracting solution is concentrated under reduced pressure into the concentrate for being 1.26 in 60 DEG C of relative densities；
4) in the white wine that every 500ml alcoholic strength is 65 °, 1ml concentrate is added, alcoholic drink mixed with fruit juice can be configured to.
Comparative example 1
The production method of the alcoholic drink mixed with fruit juice of this comparative example is same as Example 1, the difference is that only, the alcoholic drink mixed with fruit juice of this comparative example by
10 parts of pueraria lobata, 20 parts of semen coicis, 26 parts of semen ziziphi spinosae, 30 parts of honeysuckle, 28 parts of fructus lycii, 10 parts of raspberry, 14 parts of hoveniae semoveniae semen, hawthorn
6 parts are made.
Comparative example 2
The production method of the alcoholic drink mixed with fruit juice of this comparative example is same as Example 1, the difference is that only, the alcoholic drink mixed with fruit juice of this comparative example by
28 parts of pueraria lobata, 20 parts of Poria cocos, 26 parts of semen ziziphi spinosae, 30 parts of honeysuckle, 10 parts of fructus lycii, 10 parts of raspberry, 14 parts of hoveniae semoveniae semen, hawthorn 6
Part is made.
Test case
1, quality is tested and assessed
Experienced composition of personnel appraisal group of judging is chosen respectively to feel alcoholic drink mixed with fruit juice made from 1-5 of the embodiment of the present invention
Official's metrics evaluation, as a result are as follows:
Appearance: clear, glossy, deposit-free and suspended matter；Fragrance: Chinese medicine perfume (or spice) and aroma are coordinated, and aftertaste is long,
Lingering fragrance assails the nostrils；Flavour: alcoholic strength is moderate, and flavour relaxes along coordination, free from extraneous odour.
Physical and chemical index: (20 DEG C) of alcoholic strength are 18-23%, and sugar-free extract >=15g/L, total reducing sugar (with glucose meter) is 50-
75g/L, total acid (in terms of tartaric acid) are 0.2-0.35g/L.
Microorganism defends index: Escherichia coli flora < 2, total number of bacteria≤10, pathogenic bacteria are not detected.
2, toxicity test
10 healthy BALB/c mouses (female, fifty-fifty, the weight 18-22g of hero) are taken, carry out adaptable fed 12h, room before testing
Interior temperature is (25 ± 2) DEG C.Mouse is randomly divided into control group and test group, every group each 5, control group: is normally raised.Test
Group: alcoholic drink mixed with fruit juice made from stomach-filling embodiment 1, stomach-filling amount are 2mL/10gbw, and conventinal breeding is carried out after stomach-filling, and daily stomach-filling is primary,
Continuous gavage 1 week.Be observed continuously after stomach-filling 14 days, the mouse fur of control group and test group is smooth, appearance, behavior,
Situations such as diet, activity, secretion, excreta, is showed no exception, without dead mouse.
The result shows that: the alcoholic drink mixed with fruit juice of the embodiment of the present invention belongs to nontoxic grade.
3, function for tonifying kidney evaluation test
120 healthy BALB/c mouses (male, weight 18-22g) are taken, carry out adaptable fed 12h, Indoor Temperature before testing
Degree is (25 ± 2) DEG C.Mouse is randomly divided into model group, blank control group, test 1-5 group, control 1-2 group, wine base control group,
Every group each 12.
Modeling: in addition to blank control group, other each groups daily intramuscular injection hydrocortisone 25mg/kg, continuous 7 days.
Administration: modeling starts simultaneously at gastric infusion, wherein alcoholic drink mixed with fruit juice made from test 1-5 group difference tank stomach embodiment 1-5,
Compare 1-2 group: alcoholic drink mixed with fruit juice made from tank stomach comparative example 1-2 respectively, the white wine that wine base control group tank stomach alcoholic strength is 55 °, model group
Give isometric distilled water respectively with blank control group, it is 0.2mL/10gbw that the dosage of the above each group is identical, is filled daily
Stomach 1 time, continuous gavage 3 days.After last stomach-filling 1h, weight, the body temperature, autonomic activities number of each group mouse are recorded, the results are shown in Table
1。
Table 1
* the P < 0.05 compared with model group；* P < 0.01 compared with model group.
As can be seen from Table 1, compared with model group, the weight of each group mouse, body temperature, autonomic activities number have increase.
Wherein, the weight of the mouse in 2 groups of test, body temperature, autonomic activities number have conspicuousness increase, and increasing degree is obvious
Higher than other groups, illustrate that the ratio in embodiment 2 between each component is more particularly suitable.
4, sobering up and liver protecting functions evaluation test
96 healthy BALB/c mouses (female, fifty-fifty, the weight 18-22g of hero) are taken, carry out adaptable fed 12h, room before testing
Interior temperature is (25 ± 2) DEG C.Mouse is randomly divided into model control group, test 1-5 group, compares 1-2 group, every group each 12.
In addition to model control group, alcoholic drink mixed with fruit juice made from test 1-5 group difference stomach-filling embodiment 1-5, control 1-2 group difference tank stomach
Alcoholic drink mixed with fruit juice made from comparative example 1-2, model control group give isometric distilled water, and the dosage of the above each group is identical, is 0.4mL/
10gbw, daily stomach-filling 1 time, continuous gavage 6 days.After last stomach-filling 1h, every intragastric administration on mice gives 56 degree of Red Star strong, colourless liquor distilled from sorghum
16ml/kg.Pluck eyeball after 1h and take blood, separate serum, by kit specification requirement measure glutamic-pyruvic transaminase (ALT) in serum,
The activity of glutamic-oxalacetic transaminease (AST).It takes cervical dislocation after blood to put to death, takes liver to weigh, 10% liver homogenate liquid is made.It is said by kit
Bright book requires measurement hepatic tissue GSH-PX activity (GSH), malonaldehyde (MDA), the activity of alcohol dehydrogenase (ADH).It the results are shown in Table
2。
Table 2
| Group | Glutathione (mg/g) | Malonaldehyde (μm ol/g) | Alcohol dehydrogenase (U/mg) |
| Model control group | 9.3±1.8 | 6.4±0.8 | 11.5±3.7 |
| Test 1 group | 12.0±1.5 | 5.0±0.7 | 16.4±3.0 |
| Test 2 groups | 12.8±0.9** | 4.6±0.7* | 17.2±2.8** |
| Test 3 groups | 11.8±1.0 | 4.8±0.9 | 15.8±2.5 |
| Test 4 groups | 11.5±1.2 | 4.8±1.0 | 16.2±3.2 |
| Test 5 groups | 12.2±1.7 | 4.7±0.6 | 16.0±4.5 |
| Compare 1 group | 10.6±0.9 | 5.8±0.8 | 14.0±2.9 |
| Compare 2 groups | 10.2±1.2 | 6.1±1.0 | 14.4±3.1 |
* the P < 0.05 compared with model control group；* P < 0.01 compared with model control group.
As can be seen from Table 2, compared with model control group, the alcoholic drink mixed with fruit juice of the embodiment of the present invention and comparative example can reduce animal
The activity of malonaldehyde in liver organization increases the activity of glutathione and alcohol dehydrogenase, to cause hepatic injury to have alcohol
Protective effect.Compared with control 1-2 group, the alcoholic drink mixed with fruit juice of the present embodiment causes the protective value of hepatic injury more excellent alcohol.
5, clinical test
Choose the subject of this test of 180 voluntary participations, subject's symptom: soreness and weakness of waist and knees, dysphoria in chestpalms-soles, the dry pharynx of mouth
It is dry, hectic fever night sweat, insomnia forgetfulness.Men and women each 90.All subjects are randomly divided into five groups, every group each 36.Every group of patient
It is not statistically significant (P > 0.05) in the basic documents comparing difference such as gender, age, course of disease, it is comparable.
Five groups of subjects drink alcoholic drink mixed with fruit juice made from 1-5 of the embodiment of the present invention respectively, and 10mL/ times, 3 times/day, 4 weeks are 1 treatment
Journey, is used continuously 3 courses for the treatment of, observation subject before the treatment, after clinical efficacy.
Efficacy determination: symptom disappear or mostly disappear is to cure；It is effective that symptom, which has clear improvement,；Symptom is nothing without improving
Effect.Treatment results are shown in Table 3.
Table 3
| Group | Number of cases | It cures | Effectively | In vain | Total effective rate/% |
| Embodiment 1 | 36 | 21 | 12 | 3 | 91.7 |
| Embodiment 2 | 36 | 23 | 11 | 2 | 94.4 |
| Embodiment 3 | 36 | 18 | 15 | 3 | 91.7 |
| Embodiment 4 | 36 | 15 | 17 | 4 | 88.9 |
| Embodiment 5 | 36 | 20 | 13 | 3 | 91.7 |
As can be seen from Table 3, for subject after using alcoholic drink mixed with fruit juice made from the embodiment of the present invention, total effective rate is higher than 88%,
And all subjects do not occur adverse reaction, illustrate the alcoholic drink mixed with fruit juice of the embodiment of the present invention can safely and effectively improve insomnia,
The symptom of kidney deficiency.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention are fallen within the scope of the claimed invention.
Claims (9)
1. a kind of alcoholic drink mixed with fruit juice, which is characterized in that the alcoholic drink mixed with fruit juice is mixed by wine base and auxiliary material, and the wine base is that alcoholic strength is 50-
65 ° of white wine, the auxiliary material are made of the medicinal material of following parts by weight: 20-30 parts of pueraria lobata, 20-30 parts of semen coicis, semen ziziphi spinosae
20-30 parts, 20-30 parts of honeysuckle, 10-15 parts of fructus lycii, 10-15 parts of raspberry, 10-15 parts of hoveniae semoveniae semen, 5-10 parts of hawthorn.
2. alcoholic drink mixed with fruit juice according to claim 1, which is characterized in that the auxiliary material is made of the medicinal material of following parts by weight: Pueraria lobota
25 parts of root, 25 parts of semen coicis, 25 parts of semen ziziphi spinosae, 25 parts of honeysuckle, 12 parts of fructus lycii, 12 parts of raspberry, 12 parts of hoveniae semoveniae semen, hawthorn 8
Part.
3. a kind of production method of alcoholic drink mixed with fruit juice described in claim 1, which is characterized in that the described method comprises the following steps:
1) pueraria lobata, semen coicis, semen ziziphi spinosae, honeysuckle, fructus lycii, raspberry, the hoveniae semoveniae semen, hawthorn of corresponding parts by weight are weighed, it will
Above-mentioned medicinal material is placed in extractor, is added water to cook, the isolated dregs of a decoction and medical fluid, and medical fluid refrigeration is spare；
2) dregs of a decoction for obtaining step 1) are placed in cylinder spontaneous fermentation 22-25 days, then add 2 parts of yellow rice wine, 1 part of salt, 1 part of ginger,
2 parts of vinegar, continue fermentation 5-8 days；
3) mixture that step 2) obtains is placed in extractor, and then the medical fluid got ready in step 1) is added in extractor,
It decocts, filtering obtains extracting solution, and the extracting solution is concentrated under reduced pressure into concentrate；
4) concentrate is added in wine base, mixes, alcoholic drink mixed with fruit juice can be configured to.
4. the production method of alcoholic drink mixed with fruit juice according to claim 3, which is characterized in that in step 1), the step added water to cook
Suddenly are as follows: the water that 6-8 times of medicinal material total weight is measured is added and is decocted 1-1.5 hours at 90-100 DEG C.
5. the production method of alcoholic drink mixed with fruit juice according to claim 3, which is characterized in that in step 2), fermentation temperature 30-37
DEG C, fermentation humidity is 70-80%.
6. the production method of alcoholic drink mixed with fruit juice according to claim 3, which is characterized in that in step 3), the step of the decoction are as follows:
80-100 DEG C decoction 1-1.5 hours.
7. the production method of alcoholic drink mixed with fruit juice according to claim 3, which is characterized in that in step 3), carried out using strainer
Filter, pore size filter 0.1mm.
8. the production method of alcoholic drink mixed with fruit juice according to claim 3, which is characterized in that in step 3), the extracting solution is depressurized
It is condensed into, in the concentrate that 60 DEG C of relative densities are 1.25-1.27.
9. the production method of alcoholic drink mixed with fruit juice according to claim 8, which is characterized in that in step 4), in every 500ml wine base, add
Enter 1ml concentrate, alcoholic drink mixed with fruit juice can be configured to.
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