CN110201069A - A kind of rheumatism bone disease magistral medicines that can act on trauma skin surface - Google Patents
A kind of rheumatism bone disease magistral medicines that can act on trauma skin surface Download PDFInfo
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Abstract
A kind of rheumatism bone disease magistral medicines that can act on trauma skin surface, the formula include: borneol, Radix Aconiti, amber, pyrolusite, calcined gypsum, olibanum, the root of Dahurain angelica, the root of fangji, radix saposhnikoviae, corydalis tuber, pearl, Radix Angelicae Pubescentis, lycopodium calvatum, myrrh, cortex cinnamomi, Moschus, safflower, calamine.Affected part can only be affixed on the present invention overcomes traditional plaster and cannot can be treated toward the drawbacks for the treatment of is pasted at skin wound newly puncture epidermis position patch, and making thoroughly to eradicate rheumatism becomes possible.The indexs such as DAS28, VAS pain scores, erythrocyte sedimentation rate, C reactive protein can be significantly improved simultaneously, improve the quality of life of patient, to provide New methods in working by Chinese traditional treatment rheumatic bone pain.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, in particular to a kind of rheumatism bone disease that can act on trauma skin surface is matched
Recipe.
Background technique
Rheumatism bone disease includes arthritis, rheumatalgia, osteoproliferation, cervical vertebra pain, pain in the loins, scapulohumeral periarthritis, sciatica, loins
Disk is prominent, and the mainly blood circulation due to caused by chill is obstructed, cause include flesh, ligament, synovial bursa, fascia nutrition supply
Disease caused by bad, or because standing or walking for a long time and be held in certain posture for a long time, due to muscle drawing or tear
De-, bleeding, organization of hematoma form the disease of osteoproliferation of thorn-like or lip sample etc.Arthropathy in addition to having pain still with
Swelling and moving obstacle, in breaking-out with alleviate the alternate chronic course of disease, some patientss and may occur in which that joint is disabled and viscera function
Failure.
Treatment for rheumatism bone disease is usually drug therapy and Dressed plaster, and currently on the market for treating rheumatic bone
The drug of disease is mostly Western medicine, and side effect is larger, is not easy to patient's long-term use, and Dressed plaster is more troublesome, and will affect patient
Bathing is made troubles to minimal invasive treatment.The common drawback of these plaster is that curative effect is slow, and the patch treatment time is long, and efficacy time is short, recurrence
Rate is high；And its allergy rate is high, and numerous patients cannot be used continuously；Furthermore it avoids when most of rheumatic bone pain medicine use toward wound
Place's patch, cannot exactly use at the new cut of skin, therefore narrow application range.
Summary of the invention
It is an object of the invention to overcome the deficiency of the above-mentioned prior art, trauma skin surface can be acted on by providing one kind
Rheumatism bone disease magistral medicines, its good effect, drug effect is lasting, patient patch after allergy rate it is low, it is applied widely.
The purpose of the present invention is what is realized by following proposal:
One kind proposed by the present invention can act on the rheumatism bone disease magistral medicines on trauma skin surface, including following parts by weight
Raw material: 5-10 parts of borneol, 10-20 parts of Radix Aconiti, 20-30 parts of amber, 10-20 parts of pyrolusite, 25-35 parts of calcined gypsum, olibanum
20-30 parts, 20-25 parts of the root of Dahurain angelica, 30-40 parts of the root of fangji, 10-15 parts of radix saposhnikoviae, 15-20 parts of corydalis tuber, 20-30 parts of pearl, Radix Angelicae Pubescentis 15-25
Part, 10-30 parts of lycopodium calvatum, 25-35 parts of myrrh, 15-20 parts of cortex cinnamomi, 8-13 parts of Moschus, 15-25 parts of safflower, calamine 15-25
Part；
Preferably, the raw material including following parts by weight: 7-9 parts of borneol, 14-18 parts of Radix Aconiti, 24-28 parts of amber, unknown
12-18 parts different, 28-32 parts of calcined gypsum, 23-27 parts of olibanum, 22-24 parts of the root of Dahurain angelica, 33-38 parts of the root of fangji, radix saposhnikoviae 12-14 parts, corydalis tuber
16-18 parts, 22-28 parts of pearl, 17-22 parts of Radix Angelicae Pubescentis, 15-25 parts of lycopodium calvatum, 28-32 parts of myrrh, 16-18 parts of cortex cinnamomi, Moschus 10-
12 parts, 18-22 parts of safflower, 18-22 parts of calamine；
Preferably, preparation method includes the following steps:
Step 1, pre-treatment: choose borneol 5-10 parts, 10-20 parts of Radix Aconiti, 20-30 parts of amber, 10-20 parts of pyrolusite,
25-35 parts of calcined gypsum, 20-30 parts of olibanum, 20-25 parts of the root of Dahurain angelica, 30-40 parts of the root of fangji, 10-15 parts of radix saposhnikoviae, 15-20 parts of corydalis tuber, treasure
20-30 parts of pearl, 15-25 parts of Radix Angelicae Pubescentis, 10-30 parts of lycopodium calvatum, 25-35 parts of myrrh, 15-20 parts of cortex cinnamomi, 8-13 parts of Moschus, safflower
15-25 parts, 15-25 parts of calamine, cleaning, drying；
Step 2 crushes, sieving: crushing after traditional Chinese medicinal material raw materials that step 1 obtains are mixed and obtains medicinal powder, then by medicinal powder
Sieving, obtains thin medicinal powder；
Step 3 adjusts medicine, pill: the stirring of thin medicinal powder, the kneading that step 2 is obtained obtain pill；
Step 4, polishing, capping: the pill that step 3 is obtained is put into pellet processing machine and is polished and heated, and obtains finished product
Rheumatism bone disease pill；
Preferably, in the step 1, the drying temperature is 70~78 DEG C；
Preferably, in the step 2, the sieving is that medicinal powder is crossed to No. seven sieves；
Preferably, in the step 3, the medicinal spoon of tune is poured into the stirring basin for filling medicinal powder, then with stirring
Stick carries out circumference stirring, until can't see dry medicinal powder in basin until stirring, then with the hands integrates again, obtains bolus.
In the present invention, olibanum, myrrh, pyrolusite, safflower be blood circulation and stasis-eliminating medicine, safflower can also removing pattogenic heat from the blood and toxic material from the body, the root of fangji,
Member is acted like a bully medicine for rheumatism, and lycopodium calvatum, Radix Aconiti, calcined gypsum have the effect of heat-clearing, myogenic, convergence, and amber is sedative, solely
Living, pearl is that anti-inflammatory drug is ached in town, and Moschus, borneol are awaking drug, and radix saposhnikoviae, the root of Dahurain angelica, cortex cinnamomi are warm-pungent diaphoretic drug, and calamine is external application
Medicine, said medicine share energy activating microcirculation and removing stasis medicinal, dispelling wind and eliminating dampness, clearing and activating the channels and collaterals, swelling and pain relieving, dephlogistication and promoting nuscle growth.
Beneficial effects of the present invention:
1, the present invention is applied widely.Traditional plaster cannot be acted on to paste at the new cut of skin and be treated, and the present invention is reversible
The patch of traditional plaster treats method, can treat newly puncture epidermis position patch, and making thoroughly to eradicate rheumatism becomes possible.
2, the present invention has and expels pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, promoting blood circulation to remove blood stasis, and the effect of regulating qi-flowing for relieving pain solves rheumatism, bone
The problem of the patient medications such as disease inconvenience, has no toxic side effect, and manufacture craft is simple.
3, the present invention can significantly improve arthroncus number, arthralgia degree, improve DAS28, VAS pain scores, erythrocyte sedimentation rate,
The indexs such as C reactive protein improve the quality of life of patient, to provide new approaches, new side by Chinese traditional treatment rheumatic bone pain
Method.
Specific embodiment
Combined with specific embodiments below the present invention is made further to explain.
Embodiment one
A kind of magistral medicines for treating rheumatism bone disease is proposed in the present embodiment, the raw material including following parts by weight: borneol 5
Part, 10 parts of Radix Aconiti, 20 parts of amber, 10 parts of pyrolusite, 25 parts of calcined gypsum, 20 parts of olibanum, 20 parts of the root of Dahurain angelica, 30 parts of the root of fangji, radix saposhnikoviae
10 parts, 15 parts of corydalis tuber, 20 parts of pearl, 15 parts of Radix Angelicae Pubescentis, 10 parts of lycopodium calvatum, 25 parts of myrrh, 15 parts of cortex cinnamomi, 8 parts of Moschus, safflower 15
Part, 15 parts of calamine；
Its production method the following steps are included:
Step 1
Pre-treatment: 5 parts of the higher borneol of quality for meeting " Chinese Pharmacopoeia " 2015 editions, 10 parts of Radix Aconiti, amber 20 are chosen
Part, 10 parts of pyrolusite, 25 parts of calcined gypsum, 20 parts of olibanum, 20 parts of the root of Dahurain angelica, 30 parts of the root of fangji, windproof 10 parts, 15 parts of corydalis tuber, pearl 20
Part, 15 parts of Radix Angelicae Pubescentis, 10 parts of lycopodium calvatum, 25 parts of myrrh, 15 parts of cortex cinnamomi, 8 parts of Moschus, 15 parts of safflower, 15 parts of calamine.
Cleaning: being put into clear water reserviors for above-mentioned medicinal material and be rinsed, and removes impurity.
Drying: the Chinese medicine after above-mentioned cleaned uniformly being laid in drying box and carries out drying and processing, drying temperature
It is 70 DEG C.
Step 2
It crushes, mixing: the traditional Chinese medicinal material raw materials after above-mentioned drying being put into model DLF-18 Chinese medicine pulverizer and are carried out
It crushes, then smashed medicinal material mixture is put into medicine powder mixer and is uniformly mixed, after taking-up, obtains medicinal powder.
Sieving: above-mentioned medicinal powder is crossed into No. seven sieves, obtains thin medicinal powder.
Step 3
It adjusts medicine: pouring into the stirring basin for filling thin medicinal powder, then carry out circumference stirring with stirring rod, seen until in stirring basin
It until less than dry medicinal powder, then with the hands integrates again, obtains bolus.
Pill: above-mentioned bolus is machined to multiple pills by Chinese medicine pilling, obtains pill.
Step 4
Polishing, capping: above-mentioned pill is put into the roller of model HK-93B Chinese medicinal pills preparing machine and is polished and is added
Heat after taking-up, obtains finished product rheumatism bone disease pill.
Embodiment two
A kind of magistral medicines for treating rheumatism bone disease is proposed in the present embodiment, the raw material including following parts by weight: borneol 10
Part, 20 parts of Radix Aconiti, 30 parts of amber, 20 parts of pyrolusite, 35 parts of calcined gypsum, 30 parts of olibanum, 25 parts of the root of Dahurain angelica, 40 parts of the root of fangji, radix saposhnikoviae
15 parts, 20 parts of corydalis tuber, 30 parts of pearl, 25 parts of Radix Angelicae Pubescentis, 30 parts of lycopodium calvatum, 35 parts of myrrh, 20 parts of cortex cinnamomi, 13 parts of Moschus, safflower
25 parts, 25 parts of calamine；
Its production method the following steps are included:
Step 1
Pre-treatment: 10 parts of the higher borneol of quality for meeting " Chinese Pharmacopoeia " 2015 editions, 20 parts of Radix Aconiti, amber 30 are chosen
Part, 20 parts of pyrolusite, 35 parts of calcined gypsum, 30 parts of olibanum, 25 parts of the root of Dahurain angelica, 40 parts of the root of fangji, windproof 15 parts, 20 parts of corydalis tuber, pearl 30
Part, 25 parts of Radix Angelicae Pubescentis, 30 parts of lycopodium calvatum, 35 parts of myrrh, 20 parts of cortex cinnamomi, 13 parts of Moschus, 25 parts of safflower, 25 parts of calamine.
Cleaning: being put into clear water reserviors for above-mentioned medicinal material and be rinsed, and removes impurity.
Drying: the Chinese medicine after above-mentioned cleaned uniformly being laid in drying box and carries out drying and processing, drying temperature
It is 78 DEG C.
Step 2
It crushes, mixing: the traditional Chinese medicinal material raw materials after above-mentioned drying being put into model DLF-18 Chinese medicine pulverizer and are carried out
It crushes, then smashed medicinal material mixture is put into medicine powder mixer and is uniformly mixed, after taking-up, obtains medicinal powder.
Sieving: above-mentioned medicinal powder is crossed into No. seven sieves, obtains thin medicinal powder.
Step 3
It adjusts medicine: pouring into the stirring basin for filling thin medicinal powder, then carry out circumference stirring with stirring rod, seen until in stirring basin
It until less than dry medicinal powder, then with the hands integrates again, obtains bolus.
Pill: above-mentioned bolus is machined to multiple pills by Chinese medicine pilling, obtains pill.
Step 4
Polishing, capping: above-mentioned pill is put into the roller of model HK-93B Chinese medicinal pills preparing machine and is polished and is added
Heat after taking-up, obtains finished product rheumatism bone disease pill.
Embodiment three
A kind of magistral medicines for treating rheumatism bone disease is proposed in the present embodiment, the raw material including following parts by weight: borneol 7
Part, 14 parts of Radix Aconiti, 24 parts of amber, 12 parts of pyrolusite, 28 parts of calcined gypsum, 23 parts of olibanum, 22 parts of the root of Dahurain angelica, 33 parts of the root of fangji, radix saposhnikoviae
12 parts, 16 parts of corydalis tuber, 22 parts of pearl, 17 parts of Radix Angelicae Pubescentis, 15 parts of lycopodium calvatum, 28 parts of myrrh, 16 parts of cortex cinnamomi, 10 parts of Moschus, safflower
18 parts, 18 parts of calamine；
Its production method the following steps are included:
Step 1
Pre-treatment: 7 parts of the higher borneol of quality for meeting " Chinese Pharmacopoeia " 2015 editions, 14 parts of Radix Aconiti, amber 24 are chosen
Part, 12 parts of pyrolusite, 28 parts of calcined gypsum, 23 parts of olibanum, 22 parts of the root of Dahurain angelica, 33 parts of the root of fangji, windproof 12 parts, 16 parts of corydalis tuber, pearl 22
Part, 17 parts of Radix Angelicae Pubescentis, 15 parts of lycopodium calvatum, 28 parts of myrrh, 16 parts of cortex cinnamomi, 10 parts of Moschus, 18 parts of safflower, 18 parts of calamine.
Cleaning: being put into clear water reserviors for above-mentioned medicinal material and be rinsed, and removes impurity.
Drying: the Chinese medicine after above-mentioned cleaned uniformly being laid in drying box and carries out drying and processing, drying temperature
It is 72 DEG C.
Step 2
It crushes, mixing: the traditional Chinese medicinal material raw materials after above-mentioned drying being put into model DLF-18 Chinese medicine pulverizer and are carried out
It crushes, then smashed medicinal material mixture is put into medicine powder mixer and is uniformly mixed, after taking-up, obtains medicinal powder.
Sieving: above-mentioned medicinal powder is crossed into No. seven sieves, obtains thin medicinal powder.
Step 3
It adjusts medicine: pouring into the stirring basin for filling thin medicinal powder, then carry out circumference stirring with stirring rod, seen until in stirring basin
It until less than dry medicinal powder, then with the hands integrates again, obtains bolus.
Pill: above-mentioned bolus is machined to multiple pills by Chinese medicine pilling, obtains pill.
Step 4
Polishing, capping: above-mentioned pill is put into the roller of model HK-93B Chinese medicinal pills preparing machine and is polished and is added
Heat after taking-up, obtains finished product rheumatism bone disease pill.
Example IV
A kind of magistral medicines for treating rheumatism bone disease is proposed in the present embodiment, the raw material including following parts by weight: borneol 9
Part, 18 parts of Radix Aconiti, 28 parts of amber, 18 parts of pyrolusite, 32 parts of calcined gypsum, 27 parts of olibanum, 24 parts of the root of Dahurain angelica, 38 parts of the root of fangji, radix saposhnikoviae
14 parts, 18 parts of corydalis tuber, 28 parts of pearl, 22 parts of Radix Angelicae Pubescentis, 25 parts of lycopodium calvatum, 32 parts of myrrh, 18 parts of cortex cinnamomi, 12 parts of Moschus, safflower
22 parts, 22 parts of calamine；
Its production method the following steps are included:
Step 1
Pre-treatment: 9 parts of the higher borneol of quality for meeting " Chinese Pharmacopoeia " 2015 editions, 18 parts of Radix Aconiti, amber 28 are chosen
Part, 18 parts of pyrolusite, 32 parts of calcined gypsum, 27 parts of olibanum, 24 parts of the root of Dahurain angelica, 38 parts of the root of fangji, windproof 14 parts, 18 parts of corydalis tuber, pearl 28
Part, 22 parts of Radix Angelicae Pubescentis, 25 parts of lycopodium calvatum, 32 parts of myrrh, 18 parts of cortex cinnamomi, 12 parts of Moschus, 22 parts of safflower, 22 parts of calamine.
Cleaning: being put into clear water reserviors for above-mentioned medicinal material and be rinsed, and removes impurity.
Drying: the Chinese medicine after above-mentioned cleaned uniformly being laid in drying box and carries out drying and processing, drying temperature
It is 76 DEG C.
Step 2
It crushes, mixing: the traditional Chinese medicinal material raw materials after above-mentioned drying being put into model DLF-18 Chinese medicine pulverizer and are carried out
It crushes, then smashed medicinal material mixture is put into medicine powder mixer and is uniformly mixed, after taking-up, obtains medicinal powder.
Sieving: above-mentioned medicinal powder is crossed into No. seven sieves, obtains thin medicinal powder.
Step 3
It adjusts medicine: pouring into the stirring basin for filling thin medicinal powder, then carry out circumference stirring with stirring rod, seen until in stirring basin
It until less than dry medicinal powder, then with the hands integrates again, obtains bolus.
Pill: above-mentioned bolus is machined to multiple pills by Chinese medicine pilling, obtains pill.
Step 4
Polishing, capping: above-mentioned pill is put into the roller of model HK-93B Chinese medicinal pills preparing machine and is polished and is added
Heat after taking-up, obtains finished product rheumatism bone disease pill.
Embodiment five
A kind of magistral medicines for treating rheumatism bone disease is proposed in the present embodiment, the raw material including following parts by weight: borneol 8
Part, 15 parts of Radix Aconiti, 26 parts of amber, 15 parts of pyrolusite, 30 parts of calcined gypsum, 25 parts of olibanum, 23 parts of the root of Dahurain angelica, 35 parts of the root of fangji, radix saposhnikoviae
13 parts, 17 parts of corydalis tuber, 25 parts of pearl, 20 parts of Radix Angelicae Pubescentis, 20 parts of lycopodium calvatum, 30 parts of myrrh, 17 parts of cortex cinnamomi, 11 parts of Moschus, safflower
20 parts, 20 parts of calamine；
Its production method the following steps are included:
Step 1
Pre-treatment: 8 parts of the higher borneol of quality for meeting " Chinese Pharmacopoeia " 2015 editions, 15 parts of Radix Aconiti, amber 26 are chosen
Part, 15 parts of pyrolusite, 30 parts of calcined gypsum, 25 parts of olibanum, 23 parts of the root of Dahurain angelica, 35 parts of the root of fangji, windproof 13 parts, 17 parts of corydalis tuber, pearl 25
Part, 20 parts of Radix Angelicae Pubescentis, 20 parts of lycopodium calvatum, 30 parts of myrrh, 17 parts of cortex cinnamomi, 11 parts of Moschus, 20 parts of safflower, 20 parts of calamine.
Cleaning: being put into clear water reserviors for above-mentioned medicinal material and be rinsed, and removes impurity.
Drying: the Chinese medicine after above-mentioned cleaned uniformly being laid in drying box and carries out drying and processing, drying temperature
It is 76 DEG C.
Step 2
It crushes, mixing: the traditional Chinese medicinal material raw materials after above-mentioned drying being put into model DLF-18 Chinese medicine pulverizer and are carried out
It crushes, then smashed medicinal material mixture is put into medicine powder mixer and is uniformly mixed, after taking-up, obtains medicinal powder.
Sieving: above-mentioned medicinal powder is crossed into No. seven sieves, obtains thin medicinal powder.
Step 3
It adjusts medicine: pouring into the stirring basin for filling thin medicinal powder, then carry out circumference stirring with stirring rod, seen until in stirring basin
It until less than dry medicinal powder, then with the hands integrates again, obtains bolus.
Pill: above-mentioned bolus is machined to multiple pills by Chinese medicine pilling, obtains pill.
Step 4
Polishing, capping: above-mentioned pill is put into the roller of model HK-93B Chinese medicinal pills preparing machine and is polished and is added
Heat after taking-up, obtains finished product rheumatism bone disease pill.
Embodiment six
A kind of magistral medicines for treating rheumatism bone disease is proposed in the present embodiment, the raw material including following parts by weight: borneol 9
Part, 16 parts of Radix Aconiti, 26 parts of amber, 15 parts of pyrolusite, 31 parts of calcined gypsum, 25 parts of olibanum, 23 parts of the root of Dahurain angelica, 32 parts of the root of fangji, radix saposhnikoviae
13 parts, 18 parts of corydalis tuber, 25 parts of pearl, 20 parts of Radix Angelicae Pubescentis, 21 parts of lycopodium calvatum, 30 parts of myrrh, 17 parts of cortex cinnamomi, 11 parts of Moschus, safflower
21 parts, 19 parts of calamine；
Its production method the following steps are included:
Step 1
Pre-treatment: 9 parts of the higher borneol of quality for meeting " Chinese Pharmacopoeia " 2015 editions, 16 parts of Radix Aconiti, amber 26 are chosen
Part, 15 parts of pyrolusite, 31 parts of calcined gypsum, 25 parts of olibanum, 23 parts of the root of Dahurain angelica, 32 parts of the root of fangji, windproof 13 parts, 18 parts of corydalis tuber, pearl 25
Part, 20 parts of Radix Angelicae Pubescentis, 21 parts of lycopodium calvatum, 30 parts of myrrh, 17 parts of cortex cinnamomi, 11 parts of Moschus, 21 parts of safflower, 19 parts of calamine.
Cleaning: being put into clear water reserviors for above-mentioned medicinal material and be rinsed, and removes impurity.
Drying: the Chinese medicine after above-mentioned cleaned uniformly being laid in drying box and carries out drying and processing, drying temperature
It is 75 DEG C.
Step 2
It crushes, mixing: the traditional Chinese medicinal material raw materials after above-mentioned drying being put into model DLF-18 Chinese medicine pulverizer and are carried out
It crushes, then smashed medicinal material mixture is put into medicine powder mixer and is uniformly mixed, after taking-up, obtains medicinal powder.
Sieving: above-mentioned medicinal powder is crossed into No. seven sieves, obtains thin medicinal powder.
Step 3
It adjusts medicine: pouring into the stirring basin for filling thin medicinal powder, then carry out circumference stirring with stirring rod, seen until in stirring basin
It until less than dry medicinal powder, then with the hands integrates again, obtains bolus.
Pill: above-mentioned bolus is machined to multiple pills by Chinese medicine pilling, obtains pill.
Step 4
Polishing, capping: above-mentioned pill is put into the roller of model HK-93B Chinese medicinal pills preparing machine and is polished and is added
Heat after taking-up, obtains finished product rheumatism bone disease pill.
Comparative example 1-3 is for evaluating the effect to trauma skin such as lycopodium calvatum, Radix Aconiti, calcined gypsum
Comparative example 1
A kind of magistral medicines for treating rheumatism bone disease is proposed in the present embodiment, the raw material including following parts by weight: borneol 7
Part, 14 parts of Radix Aconiti, 24 parts of amber, 12 parts of pyrolusite, 28 parts of calcined gypsum, 23 parts of olibanum, 22 parts of the root of Dahurain angelica, 33 parts of the root of fangji, radix saposhnikoviae
12 parts, 16 parts of corydalis tuber, 22 parts of pearl, 17 parts of Radix Angelicae Pubescentis, 28 parts of myrrh, 16 parts of cortex cinnamomi, 10 parts of Moschus, 18 parts of safflower, calamine
18 parts；
Its production method the following steps are included:
Step 1
Pre-treatment: 7 parts of the higher borneol of quality for meeting " Chinese Pharmacopoeia " 2015 editions, 14 parts of Radix Aconiti, amber 24 are chosen
Part, 12 parts of pyrolusite, 28 parts of calcined gypsum, 23 parts of olibanum, 22 parts of the root of Dahurain angelica, 33 parts of the root of fangji, windproof 12 parts, 16 parts of corydalis tuber, pearl 22
Part, 17 parts of Radix Angelicae Pubescentis, 28 parts of myrrh, 16 parts of cortex cinnamomi, 10 parts of Moschus, 18 parts of safflower, 18 parts of calamine.
Cleaning: being put into clear water reserviors for above-mentioned medicinal material and be rinsed, and removes impurity.
Drying: the Chinese medicine after above-mentioned cleaned uniformly being laid in drying box and carries out drying and processing, drying temperature
It is 72 DEG C.
Step 2
It crushes, mixing: the traditional Chinese medicinal material raw materials after above-mentioned drying being put into model DLF-18 Chinese medicine pulverizer and are carried out
It crushes, then smashed medicinal material mixture is put into medicine powder mixer and is uniformly mixed, after taking-up, obtains medicinal powder.
Sieving: above-mentioned medicinal powder is crossed into No. seven sieves, obtains thin medicinal powder.
Step 3
It adjusts medicine: pouring into the stirring basin for filling thin medicinal powder, then carry out circumference stirring with stirring rod, seen until in stirring basin
It until less than dry medicinal powder, then with the hands integrates again, obtains bolus.
Pill: above-mentioned bolus is machined to multiple pills by Chinese medicine pilling, obtains pill.
Step 4
Polishing, capping: above-mentioned pill is put into the roller of model HK-93B Chinese medicinal pills preparing machine and is polished and is added
Heat after taking-up, obtains finished product rheumatism bone disease pill.
Comparative example 2
A kind of magistral medicines for treating rheumatism bone disease is proposed in the present embodiment, the raw material including following parts by weight: borneol 7
Part, 24 parts of amber, 12 parts of pyrolusite, 28 parts of calcined gypsum, 23 parts of olibanum, 22 parts of the root of Dahurain angelica, 33 parts of the root of fangji, windproof 12 parts, corydalis tuber 16
Part, 22 parts of pearl, 17 parts of Radix Angelicae Pubescentis, 15 parts of lycopodium calvatum, 28 parts of myrrh, 16 parts of cortex cinnamomi, 10 parts of Moschus, 18 parts of safflower, calamine
18 parts；
Its production method the following steps are included:
Step 1
Pre-treatment: 7 parts of the higher borneol of quality for meeting " Chinese Pharmacopoeia " 2015 editions, 24 parts of amber, pyrolusite 12 are chosen
Part, 28 parts of calcined gypsum, 23 parts of olibanum, 22 parts of the root of Dahurain angelica, 33 parts of the root of fangji, radix saposhnikoviae 12 parts, 16 parts of corydalis tuber, 22 parts of pearl, 17 parts of Radix Angelicae Pubescentis,
15 parts of lycopodium calvatum, 28 parts of myrrh, 16 parts of cortex cinnamomi, 10 parts of Moschus, 18 parts of safflower, 18 parts of calamine.
Cleaning: being put into clear water reserviors for above-mentioned medicinal material and be rinsed, and removes impurity.
Drying: the Chinese medicine after above-mentioned cleaned uniformly being laid in drying box and carries out drying and processing, drying temperature
It is 72 DEG C.
Step 2
It crushes, mixing: the traditional Chinese medicinal material raw materials after above-mentioned drying being put into model DLF-18 Chinese medicine pulverizer and are carried out
It crushes, then smashed medicinal material mixture is put into medicine powder mixer and is uniformly mixed, after taking-up, obtains medicinal powder.
Sieving: above-mentioned medicinal powder is crossed into No. seven sieves, obtains thin medicinal powder.
Step 3
It adjusts medicine: pouring into the stirring basin for filling thin medicinal powder, then carry out circumference stirring with stirring rod, seen until in stirring basin
It until less than dry medicinal powder, then with the hands integrates again, obtains bolus.
Pill: above-mentioned bolus is machined to multiple pills by Chinese medicine pilling, obtains pill.
Step 4
Polishing, capping: above-mentioned pill is put into the roller of model HK-93B Chinese medicinal pills preparing machine and is polished and is added
Heat after taking-up, obtains finished product rheumatism bone disease pill.
Comparative example 3
A kind of magistral medicines for treating rheumatism bone disease is proposed in the present embodiment, the raw material including following parts by weight: borneol 7
Part, 14 parts of Radix Aconiti, 24 parts of amber, 12 parts of pyrolusite, 23 parts of olibanum, 22 parts of the root of Dahurain angelica, 33 parts of the root of fangji, windproof 12 parts, corydalis tuber 16
Part, 22 parts of pearl, 17 parts of Radix Angelicae Pubescentis, 15 parts of lycopodium calvatum, 28 parts of myrrh, 16 parts of cortex cinnamomi, 10 parts of Moschus, 18 parts of safflower, calamine
18 parts；
Its production method the following steps are included:
Step 1
Pre-treatment: 7 parts of the higher borneol of quality for meeting " Chinese Pharmacopoeia " 2015 editions, 14 parts of Radix Aconiti, amber 24 are chosen
Part, 12 parts of pyrolusite, 23 parts of olibanum, 22 parts of the root of Dahurain angelica, 33 parts of the root of fangji, radix saposhnikoviae 12 parts, 16 parts of corydalis tuber, 22 parts of pearl, 17 parts of Radix Angelicae Pubescentis,
15 parts of lycopodium calvatum, 28 parts of myrrh, 16 parts of cortex cinnamomi, 10 parts of Moschus, 18 parts of safflower, 18 parts of calamine.
Cleaning: being put into clear water reserviors for above-mentioned medicinal material and be rinsed, and removes impurity.
Drying: the Chinese medicine after above-mentioned cleaned uniformly being laid in drying box and carries out drying and processing, drying temperature
It is 72 DEG C.
Step 2
It crushes, mixing: the traditional Chinese medicinal material raw materials after above-mentioned drying being put into model DLF-18 Chinese medicine pulverizer and are carried out
It crushes, then smashed medicinal material mixture is put into medicine powder mixer and is uniformly mixed, after taking-up, obtains medicinal powder.
Sieving: above-mentioned medicinal powder is crossed into No. seven sieves, obtains thin medicinal powder.
Step 3
It adjusts medicine: pouring into the stirring basin for filling thin medicinal powder, then carry out circumference stirring with stirring rod, seen until in stirring basin
It until less than dry medicinal powder, then with the hands integrates again, obtains bolus.
Pill: above-mentioned bolus is machined to multiple pills by Chinese medicine pilling, obtains pill.
Step 4
Polishing, capping: above-mentioned pill is put into the roller of model HK-93B Chinese medicinal pills preparing machine and is polished and is added
Heat after taking-up, obtains finished product rheumatism bone disease pill.
As a result with analysis
1, the influence of mouse model wound healing situation is scratched to operation knife spine portion
(1) scalpel back scratches the foundation of mouse model
Take healthy Kunming mouse 135,18~22g of weight.All mouse anesthesia back parts depilation 3cm × 2cm.It uses
Scalpel scratches back of mice region 1cm × 1cm, depth 1cm, sufficiently exposes the surface of a wound, and back is selected to scratch mouse model 120
Only, 10 groups, every group 12 are randomly divided into.
(2) grouping administration and index determining
All groups are administered according to following dosage regimens:
Chinese medicine composition coating medicine-feeding prepared by embodiment 1-6 and comparative example 1-3, meanwhile, control group applies physiology salt outside
Water；Corresponding drug is applied outside every 8h, and template is affixed on surface of a wound description surface of a wound figure by daily 14:00 after scuffing, by paper weight
It is converted into surface of a wound area.And using the 1st day surface of a wound area as initial surface of a wound area, by the 1st day, 3 days, 5 days, 7 days surface of a wound
Healing area be compared with initial surface of a wound area, calculate the 3rd day, 7 days Wound healing rates, and to healing rate carry out t inspection
Compare.Healing rate=(initial surface of a wound area-do not heal surface of a wound area)/initial surface of a wound area × 100%.Define the surface of a wound completely on
Time needed for skin is wound healing time, and epithelialization is relied on and visually observed.Wound healing time is recorded, and to healing time
It carries out t inspection to compare, as a result see the table below.
Influence of the 1 inventive formulation medicine of table to wounds in mice healing state is scratched
| Group | 3d Wound healing rate/% | 7d Wound healing rate/% | Healing time/d |
| Model control group | 11.5±6.4 | 17.7±7.6 | 36.5±4.3 |
| Embodiment 1 | 75.3±15.2 | 91.2±15.3 | 12.3±2.8 |
| Embodiment 2 | 68.6±12.1 | 86.3±12.5 | 13.6±3.2 |
| Embodiment 3 | 78.6±14.4 | 96.6±11.1 | 8.1±2.0 |
| Embodiment 4 | 72.3±11.7 | 88.6±14.3 | 13.9±3.5 |
| Embodiment 5 | 76.6±14.1 | 92.3±12.6 | 12.8±3.5 |
| Embodiment 6 | 74.6±12.4 | 89.6±11.5 | 13.4±3.4 |
| Comparative example 1 | 21.5±6.2 | 34.7±5.6 | 28.6±4.2 |
| Comparative example 2 | 16.9±5.4 | 26.8±6.4 | 32.5±4.1 |
| Comparative example 3 | 13.2±6.5 | 19.9±6.5 | 34.1±3.9 |
(3) test result is shown in Table:
1) compared with model control group, each treatment group 3d, 7d Wound healing rate and wound healing time all have significantly
Sex differernce, the drug that each treatment group in this surface can be used as treatment skin trauma use.
2) compared with control group 1-3, embodiment 1-6 group healing rate is greatly improved, and healing time shortens, and is healed in 3d, 7d
All there is significant difference (p < 0.05) in terms of rate and healing time.The Chinese medicine that the embodiment of the present invention Chinese medicine composition uses
Composition (see embodiment 3) increases lycopodium calvatum compared with the drug that comparative example 1-3 Chinese medicine composition group uses, Radix Aconiti, forges
Gypsum.As it can be seen that lycopodium calvatum, Radix Aconiti, the addition of calcined gypsum and original drug matching use can promote wound healing, this may
The effect of enhancing hemostasis and pain-relieving, detumescence and promoting granulation with lycopodium calvatum, Radix Aconiti, calcined gypsum is related.
2, the therapeutic evaluation of rheumatic bone pain
Selection is hospitalized and the rheumatic bone of outpatient clinic aches patient 100, is divided into control group and examination using random digits table
Test group.Control group 50, wherein male 14, female 36, age 22-51 (35.46 ± 6.26) years old；Treatment group 50, wherein male
13, female 37, age 20-50 (34.52 ± 5.43) years old.In therapeutic process treatment group 1 do not defer to this programme medication and by
It rejects, 2 fall off；Control group 4 fall off.93 completion treatment observations.Two groups of Genders and age differences are anticipated without statistics
Adopted (P > 0.05).
Chinese medicine composition coating medicine-feeding prepared by embodiment 1-6 and comparative example 1-3, is uniformly applied in dressing, is affixed on pass
Swelling, painful area are saved, daily dressing 1 time (sticking 18h, be spaced 6h) continuous use 7d, this is first course for the treatment of, is discontinued medication
1d, then continuous use 7d terminate, and are second course for the treatment of.It observes time point: before treatment, treating 1 week, treatment half a month；The course for the treatment of is total to half a month.It is logical
The index analysis such as complex treatment front and back DAS28, VAS pain scores, erythrocyte sedimentation rate, C reactive protein are crossed, its curative effect is judged, treats simultaneously
Row Liver and kidney function and blood routine examination after preceding and treatment, and record patient's malaise symptoms.
The comparison of 2 patient outcomes of table
| Group | The effective percentage of after one week treatment | Effective percentage after treating two weeks |
| Embodiment 1 | 75.8% | 93.2% |
| Embodiment 2 | 75.3% | 92.6% |
| Embodiment 3 | 78.4% | 95.6% |
| Embodiment 4 | 75.1% | 90.1% |
| Embodiment 5 | 78.2% | 96.8% |
| Embodiment 6 | 72.4% | 92.1% |
| Comparative example 1 | 75.2% | 94.8% |
| Comparative example 2 | 72.8% | 93.9% |
| Comparative example 3 | 76.1% | 94.1% |
By to discovery, treatment 1 week, after half a month and treats half a month total effective rate without significant difference at two groups of treatments 1 week,
It is not statistically significant.Have no obvious adverse reaction simultaneously, patient tolerability is good, proves by clinical practice, by using this hair
Bright prescription can be such that the slight illness of patient greatly reduces, and promote inflammatory parameters to subside, delay disease progression, treat for rheumathritis
Provide practicable clinical method.
Although above having used general explanation, specific embodiment and test, the present invention is made to retouch in detail
It states, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Range.
Claims (6)
1. the rheumatism bone disease magistral medicines that one kind can act on trauma skin surface, which is characterized in that the magistral medicines includes
The raw material of following parts by weight: 5-10 parts of borneol, 10-20 parts of Radix Aconiti, 20-30 parts of amber, 10-20 parts of pyrolusite, calcined gypsum 25-
35 parts, 20-30 parts of olibanum, 20-25 parts of the root of Dahurain angelica, 30-40 parts of the root of fangji, 10-15 parts of radix saposhnikoviae, 15-20 parts of corydalis tuber, 20-30 parts of pearl,
15-25 parts of Radix Angelicae Pubescentis, 10-30 parts of lycopodium calvatum, 25-35 parts of myrrh, 15-20 parts of cortex cinnamomi, 8-13 parts of Moschus, 15-25 parts of safflower, furnace
Sweet stone 15-25 parts.
2. the rheumatism bone disease magistral medicines that one kind as described in claim 1 can act on trauma skin surface, which is characterized in that
The magistral medicines includes the raw material of following parts by weight: 7-9 parts of borneol, 14-18 parts of Radix Aconiti, 24-28 parts of amber, pyrolusite
12-18 parts, 28-32 parts of calcined gypsum, 23-27 parts of olibanum, 22-24 parts of the root of Dahurain angelica, 33-38 parts of the root of fangji, 12-14 parts of radix saposhnikoviae, corydalis tuber 16-
18 parts, 22-28 parts of pearl, 17-22 parts of Radix Angelicae Pubescentis, 15-25 parts of lycopodium calvatum, 28-32 parts of myrrh, 16-18 parts of cortex cinnamomi, Moschus 10-12
Part, 18-22 parts of safflower, 18-22 parts of calamine.
3. one kind as described in claim 1 can act on the preparation method of the rheumatism bone disease magistral medicines on trauma skin surface,
It is characterized in that, the preparation method the following steps are included:
Pre-treatment: step 1 chooses borneol 5-10 parts, 10-20 parts of Radix Aconiti, 20-30 parts of amber, 10-20 parts of pyrolusite, forges stone
25-35 parts of cream, 20-30 parts of olibanum, 20-25 parts of the root of Dahurain angelica, 30-40 parts of the root of fangji, 10-15 parts of radix saposhnikoviae, 15-20 parts of corydalis tuber, pearl 20-
30 parts, 15-25 parts of Radix Angelicae Pubescentis, 10-30 parts of lycopodium calvatum, 25-35 parts of myrrh, 15-20 parts of cortex cinnamomi, 8-13 parts of Moschus, safflower 15-25
Part, 15-25 parts of calamine, cleaning, drying.
Step 2 crushes, sieving: it is crushed after the traditional Chinese medicinal material raw materials that step 1 obtains are mixed and obtains medicinal powder, then medicinal powder is sieved,
Obtain thin medicinal powder.
Step 3 adjusts medicine, pill: the stirring of thin medicinal powder, the kneading that step 2 is obtained obtain pill.
Step 4, polishing, capping: the pill that step 3 is obtained is put into pellet processing machine and is polished and heated, and obtains finished product rheumatism
Osteopathy pill.
4. one kind as claimed in claim 3 can act on the preparation method of the rheumatism bone disease magistral medicines on trauma skin surface,
It is characterized in that, the drying temperature is 70~78 DEG C in the step 1.
5. one kind as claimed in claim 3 can act on the preparation method of the rheumatism bone disease magistral medicines on trauma skin surface,
It is characterized in that, the sieving is that medicinal powder is crossed to No. seven sieves in the step 2.
6. one kind as claimed in claim 3 can act on the preparation method of the rheumatism bone disease magistral medicines on trauma skin surface,
It is characterized in that, in the step 3, the medicinal spoon of tune is poured into the stirring basin for filling medicinal powder, then with stirring rod into
Then the stirring of row circumference with the hands integrates again until can't see dry medicinal powder in basin until stirring, obtains bolus.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1165011A (en) * | 1996-12-16 | 1997-11-19 | 刘彦如 | Enternal use adhesive plaster for treatment of rheumatism |
| CN102526235A (en) * | 2012-01-06 | 2012-07-04 | 高用谋 | Chinese medicinal formulation for treating rheumatic and rheumatoid diseases and preparation method of same |
-
2019
- 2019-06-28 CN CN201910578985.9A patent/CN110201069A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1165011A (en) * | 1996-12-16 | 1997-11-19 | 刘彦如 | Enternal use adhesive plaster for treatment of rheumatism |
| CN102526235A (en) * | 2012-01-06 | 2012-07-04 | 高用谋 | Chinese medicinal formulation for treating rheumatic and rheumatoid diseases and preparation method of same |
Non-Patent Citations (1)
| Title |
|---|
| 卫国等: "活血通络搽剂配合冲击波在治疗骨科慢性疼痛中的临床应用", 《中国中医骨伤科杂志》 * |
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Application publication date: 20190906 |