CN110179948A - A kind of application and preparation method thereof ached of releiving - Google Patents
A kind of application and preparation method thereof ached of releiving Download PDFInfo
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- CN110179948A CN110179948A CN201910406047.0A CN201910406047A CN110179948A CN 110179948 A CN110179948 A CN 110179948A CN 201910406047 A CN201910406047 A CN 201910406047A CN 110179948 A CN110179948 A CN 110179948A
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- essential oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- Oil, Petroleum & Natural Gas (AREA)
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- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
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- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention provides a kind of applications and preparation method thereof ached of releiving that can effectively ensure that active constituent.The preparation method of the application ached of releiving, comprising the following steps: take essential oil composition, emulsifier to be uniformly mixed, obtain oily phase；It is uniformly mixed to remove ionized water, preservative, obtains water phase；Water phase and oil are mixed, oil-in-water soak is obtained；Medicinal chart is immersed in oil-in-water soak, obtains the medicinal chart for being attached with essential oil composition；Wherein, essential oil composition includes turmeric essential oil, powder grapefruit essential oil, olibanum essential oil and black pepper essential oil.This programme obtains essential oil soak by cold technique: oil-in-water emulsified system is made in essential oil composition, then is impregnated by medicinal chart；It is different from traditional boiling herbal medicine and obtains the mode of soak, small-molecule active substance that can utmostly in retention of oil helps to promote the effect obtained that relieve the soreness applied.
Description
Technical field
The present invention relates to biologic product technology field, in particular to a kind of application and preparation method thereof ached of releiving.
Background technique
The rhythm of life of office worker is getting faster in modernization metropolis, the multiple pressure of work and life, irregular
Situations such as work and rest and shortage movement, makes more and more crowds the state of inferior health occur, and this kind of sub-health state usually shows
The symptoms such as ache for fatigue and weak, muscle arthrosis.These muscle arthrosis ache etc. symptoms again can further to the work of people and
Life brings more negative effects, to form the vicious circle of inferior health.The physiological reason that this kind of muscle arthrosis is ached is
Musculature, the damage of connective tissue and the acidic materials such as non-bacteria inflammation or lactic acid are hoarded.Common settling mode
It is to take anodyne or by physical therapies such as massage, scraping, cuppings.But anodyne can damage stomach lining mostly, side effect compared with
Greatly, it should not take for a long time；And physical therapy process is complicated, it is beautiful to influence, if careless manipulation also will cause infection.
The existing traditional handicraft for the application ached of releiving is mainly by herbal raw material mixing, boiling, tanning drug
It is applied on medicinal chart after cream and obtains applicator material, but the loss of raw material active constituent is larger in this technical process, applied
Patch effect is less obvious, and the alleviation ached to body is weaker.Therefore, it is necessary to provide a kind of active constituent of can effectively ensure that
The preparation method for the application ached of releiving.
Summary of the invention
A technical problem to be solved by this invention, which is how to provide, a kind of can effectively ensure that relaxing for active constituent
The preparation method of the slow application ached.
According to the first aspect of the invention, the present invention provides a kind of preparation method of application releived and ached, according to
The embodiment of the present invention, the preparation method of the application ached of releiving, comprising the following steps:
It takes essential oil composition, emulsifier to be uniformly mixed, obtains oily phase；
It is uniformly mixed to remove ionized water, preservative, obtains water phase；
Water phase and oil are mixed, oil-in-water soak is obtained；
Medicinal chart is immersed in oil-in-water soak, obtains the medicinal chart for being attached with essential oil composition；
Wherein, essential oil composition includes turmeric essential oil, powder grapefruit essential oil, olibanum essential oil and black pepper essential oil.
According to an embodiment of the invention, this is releived, the composition ached at least is had the advantages that
This programme obtains essential oil soak by cold technique: oil-in-water emulsified system is made in essential oil composition, then is passed through
Medicinal chart impregnates.In the present solution, on the one hand, essential oil is obtained by cold extraction mode, wherein containing the activity of more small molecule
On the other hand substance is protected essential oil molecule therein, further subtracted by the addition of emulsifier to form oil-in-water emulsified system
The loss of few wherein active material；Compared in conventional method by high temperature boil etc. the obtained small-molecule active substance of modes compared with
Few Chinese medical concrete, the small-molecule active substance that the method applied in the present invention can utmostly in retention of oil, facilitates
Promote the effect obtained that relieve the soreness applied.
In addition, the composition ached can also have following supplementary technology special according to an embodiment of the invention, this is releived
Sign:
In some embodiments of the invention, based on the total weight of oil-in-water system, the weight of essential oil composition is 3-
8%.
In some embodiments of the invention, based on the total weight of oil-in-water system, the weight of black pepper essential oil is 0.1-
3%.Wherein, when the weight of essential oil composition is when being greater than 3%, the content of adjustable other essential oils makes wherein black pepper essence
The weight of oil is 3%；And when the weight of essential oil composition is 3%, the total weight of black pepper essential oil is less than 3%.
In some embodiments of the invention, the weight ratio of essential oil composition and emulsifier is 1:(0.1-3).
In some embodiments of the invention, it is different to be selected from -20/ isosteareth -20/ of methyl gluceth for emulsifier
Ceteth -20, cetostearyl alcohol, stearine, dimethyl silicone polymer, dimethyl silicone polymer cross-linked polymeric
At least one of the smooth oleate of object, laureth -7, sorb, Polyoxyethylene Sorbitan Monooleate.
In some embodiments of the invention, preservative is selected from Phenoxyethanol, Sensiva SC50, methyl hydroxybenzoate, oxybenzene
At least one of ethyl ester, propylene glycol.
It in some embodiments of the invention, further include mixing the medicinal chart for being attached with essential oil composition with exothermic material
The step of conjunction.
In some embodiments of the invention, essential oil composition is obtained by the method for cold extraction.
According to the second aspect of the invention, the present invention provides a kind of application releived and ached, realities according to the present invention
Example is applied, which is made by above-mentioned preparation method.
Specific embodiment
It is clearly and completely described below with reference to technical effect of the embodiment to design and generation of the invention, with
It is completely understood by the purpose of the present invention, feature and effect.
Embodiment 1:
A kind of application ached of releiving, prepares in accordance with the following methods:
(1) 2 parts by weight of turmeric essential oil, 5 parts by weight of powder grapefruit essential oil, 5 parts by weight of olibanum essential oil, black pepper essential oil 1 are taken
Oily 15 parts by weight of parts by weight, Queensland nut seed, put into oily phase agitated kettle with 5 parts by weight of stearine, are warming up to 70-80
DEG C, mixing speed 20-40rpm, mixing time 20-30min obtain oily phase；
(2) remove 300 parts by weight of ionized water, 5 parts by weight of Phenoxyethanol investment water phase agitated kettle in, be warming up to 70-80 DEG C,
Mixing speed is 20-40rpm, and mixing time 20-30min obtains water phase；
(3) oil that step 1 obtains mutually is put into water phase agitated kettle, after stirring homogeneous, is cooled to room temperature to obtain oil-in-water
Soak；
(4) medicinal chart is immersed in oil-in-water soak, and stirs medicinal chart, medicinal chart is made to be thoroughly impregnated oil-in-water soak；
(5) medicinal chart of soakage water packet oil soak is dried using desiccant；
(6) several medicinal charts and the heating material bed of material are glued together, be eased the application ached.
Embodiment 2:
A kind of application ached of releiving, prepares in accordance with the following methods:
(1) turmeric clean dry is taken, crushes, is extracted using carbon dioxide supercritical extraction method, extracting pressure 30-
40Mpa, 30-50 DEG C of extraction temperature, separator pressure 20-30Mpa, 55-65 DEG C of separator temperature, disengaging time 3-5h, dioxy
Change carbon flow 20-40L/h, collection extract is Turmeric P.E；
(2) powder grapefruit essential oil, olibanum essential oil, black pepper essential oil are prepared using similar method；
(3) 10 parts by weight of turmeric essential oil, 12 parts by weight of powder grapefruit essential oil, 15 parts by weight of olibanum essential oil, black pepper essence are taken
Oily 6 parts by weight, oxidation 61 parts by weight of corn oil, put into oily phase agitated kettle with 10 parts by weight of laureth -7, are warming up to
75-85 DEG C, mixing speed 20-40rpm, mixing time 20-30min obtains oily phase；
(4) 280 parts by weight of ionized water, 5 parts by weight of Phenoxyethanol, 5 parts by weight of methyl hydroxybenzoate investment water phase agitated kettle are removed
It is interior, it is warming up to 75-85 DEG C, mixing speed 20-40rpm, mixing time 20-30min and obtains water phase；
(5) oil that step 1 obtains mutually is put into water phase agitated kettle, after stirring homogeneous, is cooled to room temperature to obtain oil-in-water
Soak；
(6) medicinal chart is immersed in oil-in-water soak, and stirs medicinal chart, medicinal chart is made to be thoroughly impregnated oil-in-water soak；
(7) medicinal chart of soakage water packet oil soak is dried using desiccant；
(8) several medicinal charts and the heating material bed of material are glued together, be eased the application ached.
Embodiment 3:
A kind of application ached of releiving, prepares in accordance with the following methods:
(1) 2 parts by weight of turmeric essential oil, 12 parts by weight of powder grapefruit essential oil, 5 parts by weight of olibanum essential oil, black pepper essential oil 5 are taken
Oily 30 parts by weight of parts by weight, Queensland nut seed, put into oily phase agitated kettle with 5 parts by weight of stearine, are warming up to 70-80
DEG C, mixing speed 20-40rpm, mixing time 20-30min obtain oily phase；
(2) it removes in smooth 5 parts by weight of the oleate investment water phase agitated kettle of 100 parts by weight of ionized water, sorb, is warming up to 70-
80 DEG C, mixing speed 20-40rpm, mixing time 20-30min obtain water phase；
(3) oil that step 1 obtains mutually is put into water phase agitated kettle, after stirring homogeneous, is cooled to room temperature to obtain oil-in-water
Soak；
(4) medicinal chart is immersed in oil-in-water soak, and stirs medicinal chart, medicinal chart is made to be thoroughly impregnated oil-in-water soak；
(5) medicinal chart of soakage water packet oil soak is dried using desiccant；
(6) by several medicinal charts and exothermic material hybrid package, be eased the application ached.
Obviously, embodiments described above is only a part of the embodiments of the present invention, instead of all the embodiments.
Within the technical scope of the present disclosure, any changes or substitutions that can be easily thought of by anyone skilled in the art,
It should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be with the protection model of claims
Subject to enclosing.
Claims (6)
1. a kind of preparation method for the application ached of releiving, which comprises the following steps:
It takes essential oil composition, emulsifier to be uniformly mixed, obtains oily phase；
It is uniformly mixed to remove ionized water, preservative, obtains water phase；
Water phase and oil are mixed, oil-in-water soak is obtained；
Medicinal chart is immersed in the oil-in-water soak, obtains the medicinal chart for being attached with essential oil composition；
Wherein, the essential oil composition includes turmeric essential oil, powder grapefruit essential oil, olibanum essential oil and black pepper essential oil.
2. the preparation method of application according to claim 1 that ache of releiving, which is characterized in that based on oil-in-water system
Total weight, the weight of the essential oil composition are 3-8%.
3. the preparation method of application according to claim 2 that ache of releiving, which is characterized in that based on oil-in-water system
Total weight, the weight of the black pepper essential oil are 0.1-3%.
4. the preparation method of application according to claim 1-3 that ache of releiving, which is characterized in that further include by
The step of medicinal chart for being attached with essential oil composition is mixed with exothermic material.
5. the preparation method of application according to claim 1-3 that ache of releiving, which is characterized in that the essential oil
Composition is obtained by the method for cold extraction.
6. a kind of application ached of releiving, which is characterized in that be made by the described in any item preparation methods of claim 1-5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910406047.0A CN110179948A (en) | 2019-05-15 | 2019-05-15 | A kind of application and preparation method thereof ached of releiving |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201910406047.0A CN110179948A (en) | 2019-05-15 | 2019-05-15 | A kind of application and preparation method thereof ached of releiving |
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| CN110179948A true CN110179948A (en) | 2019-08-30 |
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|---|---|---|---|
| CN201910406047.0A Pending CN110179948A (en) | 2019-05-15 | 2019-05-15 | A kind of application and preparation method thereof ached of releiving |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101686700A (en) * | 2007-05-30 | 2010-03-31 | 雀巢产品技术援助有限公司 | Oil-in-water emulsion and its use for the delayed release of active elements |
| CN105726385A (en) * | 2016-02-04 | 2016-07-06 | 广州静美化妆品科技有限公司 | Stimulation-free skin protection lotion containing essential oil and preparing method thereof |
| CN109745510A (en) * | 2019-03-28 | 2019-05-14 | 无限极（中国）有限公司 | It is a kind of to have effects that the essential oil composition relieved pain and its application and preparation method |
-
2019
- 2019-05-15 CN CN201910406047.0A patent/CN110179948A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101686700A (en) * | 2007-05-30 | 2010-03-31 | 雀巢产品技术援助有限公司 | Oil-in-water emulsion and its use for the delayed release of active elements |
| CN105726385A (en) * | 2016-02-04 | 2016-07-06 | 广州静美化妆品科技有限公司 | Stimulation-free skin protection lotion containing essential oil and preparing method thereof |
| CN109745510A (en) * | 2019-03-28 | 2019-05-14 | 无限极（中国）有限公司 | It is a kind of to have effects that the essential oil composition relieved pain and its application and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 熊蕊等: "《身体护理技术》", 31 January 2017, 华中科技大学出版社 * |
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Application publication date: 20190830 |
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