CN110179890A - A kind of prevention and treatment myopia and its Chinese medicine composition of complication and preparation method thereof - Google Patents

A kind of prevention and treatment myopia and its Chinese medicine composition of complication and preparation method thereof Download PDF

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CN110179890A
CN110179890A CN201910601720.6A CN201910601720A CN110179890A CN 110179890 A CN110179890 A CN 110179890A CN 201910601720 A CN201910601720 A CN 201910601720A CN 110179890 A CN110179890 A CN 110179890A
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于丽文
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/68Plantaginaceae (Plantain Family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/10Ophthalmic agents for accommodation disorders, e.g. myopia

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Abstract

A kind of prevention and treatment myopia provided by the invention and its Chinese medicine composition of complication and preparation method thereof, the Chinese medicine composition includes the raw material of following weight proportion: 20-25 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China, 15-20 parts of cassia seed, 15-20 parts of lycium barbarum, 10-15 parts of radix rehmanniae preparata, 10-15 parts of Radix Rehmanniae, 5-10 parts of radix bupleuri, 1-5 parts of Radix Paeoniae Alba, radix paeoniae rubra 1-5 parts of river preferably further include 5-10 parts of the shell of seaear, 10-15 parts of semen plantaginis;The Chinese medicine composition the preparation method is as follows: respectively by impregnating, drying, crush, wherein cassia seed stir-fries to kind skin by iron pan and pops and crush again, then stirs evenly according to the weight ratio canned into non-woven fabrics, forms traditional Chinese medicine powder packet;The application method of the traditional Chinese medicine powder packet is as follows: the traditional Chinese medicine powder packet is put into stifling instrument, Chinese medicine steam, which is formed, by stifling atomization directly acts on eye, improve ocular cell and blood circulation, dredging the channel, the promoting flow of qi and blood circulation, the passages through which vital energy circulates for hindering silt is unimpeded, to the significant effect of prevention and treatment myopia and its complication.

Description

A kind of prevention and treatment myopia and its Chinese medicine composition of complication and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition and its preparation for preventing and treating myopia and its complication Method.
Background technique
In recent years, due to universal, and the becoming younger using crowd of smart phone, pad, TV, cause Chinese children green Juvenile totality rate of myopia rises year by year, but there are many product and method of the existing prevention and treatment myopia in market and its complication, still Resultant effect is not ideal.
Myopia laser surgey: although effect can embody quickly, along with very big operation risk and nothing Poor sequelae;Visual training instrument: although without risk and obvious sequelae, usually increase eyesight burden, effect is not Obviously, or even myopia problem is caused to aggravate;Eye drops: it needs medicament dropping to enter intraocularly, increase application risk, while effect is not yet Obviously;Chinese medicine eye ointment: existing Chinese medicine eye ointment is to be applied to periocualr skin, and skin absorbs slower, it more difficult to effective traditional Chinese medicine ingredients It is transported to intraocularly, so effect is generally unobvious.
Summary of the invention
The present invention provides a kind of prevention and treatment myopia and its Chinese medicine composition of complication and preparation method thereof, using this method The traditional Chinese medicine powder packet being prepared into, is put into stifling instrument, the method being atomized by heating fumigating, directly acts on eyes and all flaw-pieces Skin improves ocular cell and blood circulation, dredging the channel, the promoting flow of qi and blood circulation, and the passages through which vital energy circulates for hindering silt is unimpeded, to prevention and treatment myopia and its simultaneously The significant effect of disease is sent out, and without any risk and sequelae.
The invention patent, a kind of prevention and treatment myopia and its Chinese medicine composition of complication and preparation method thereof, the Chinese medicine group Close the Chinese medicine material that object includes following weight proportion: 20-25 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China, 15-20 parts of cassia seed, 15-20 parts of lycium barbarum, ripe Ground 10-15 parts, 10-15 parts of Radix Rehmanniae, 5-10 parts of radix bupleuri, 1-5 parts of Radix Paeoniae Alba, radix paeoniae rubra 1-5 parts of river.
Preferably, a kind of prevention and treatment myopia and its Chinese medicine composition of complication and preparation method thereof, the Chinese medicine composition It further include the Chinese medicine material of weight proportion: 5-10 parts of the shell of seaear, 10-15 parts of semen plantaginis.
Preferably, a kind of prevention and treatment myopia and its Chinese medicine composition of complication and preparation method thereof, the Chinese medicine composition Chinese medicine material comprising following weight proportion: 22 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China, 18 parts of cassia seed, 17 parts of lycium barbarum, 12 parts of radix rehmanniae preparata, Radix Rehmanniae 12 Part, 8 parts of radix bupleuri, 3 parts of Radix Paeoniae Alba, 3 parts of river radix paeoniae rubra, 7 parts of the shell of seaear, 13 parts of semen plantaginis.
The preparation method of Chinese medicine composition described in the invention patent mainly consists of the following steps:
(1) it is impregnated respectively 45 minutes with the water of 5-10 degree, drying box is respectively put into after immersion and is dried, dry Hang Bai When chrysanthemum, cassia seed, lycium barbarum, Radix Paeoniae Alba, river radix paeoniae rubra, the shell of seaear, semen plantaginis, the control of drying box temperature is dried ripe in 40-45 degree When ground, Radix Rehmanniae, radix bupleuri, drying box temperature control in 55-60 degree, drying time be 30 minutes, place room temperature after it is spare.
(2) iron pan is heated with mild fire, iron pan is heated to hand to set a sense of warmth on pot being degree, about 170 degrees Celsius of left sides When right, by cassia seed in pot, stir-frying to kind skin pops, the micro- blistering in surface, can be pulverized with hand for degree.
(3) grind respectively, cross 120 meshes, then weigh and mix in proportion, stir evenly, it is canned enter 5cm*5cm In non-woven bag, it is prepared into traditional Chinese medicine powder packet.
In above-mentioned each traditional Chinese medicine ingredients:
FLOS CHRYSANTHEMI ALBA from Haizhou of China: mildly bitter flavor, property gas peace have the effect of relieve heat heat-clearing, calming the liver and improving eyesight, are monarch drug in a prescription.
Cassia seed: bitter but sweet flavor, it is cool in nature, there are clearing liver, improving eyesight, wind-heat cute conjunctivitis, optic atrophy, night blindness etc. can be controlled and taken a disease, be Ministerial drug.
Fructus lycii: sweet in flavor, property gas peace has the effect of nourshing kidney, moistening lung, tonifying liver, improving eyesight, is ministerial drug.
Semen plantaginis: the effect of sweet in flavor, cold nature has reducing fever and causing diuresis, and excreting dampness is treating stranguria, improving eyesight, eliminating the phlegm is ministerial drug.
The shell of seaear: taste is salty, cold in nature, have it is calming the liver, the effect of clearing liver and improving vision, be adjutant.
Radix rehmanniae preparata, it is sweet in flavor, it is warm-natured and, have effects that enriching yin of enriching blood, for adjutant.
Radix Rehmanniae: it is sweet in flavor, bitter, it is cold in nature, there is the effect of clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, be adjutant.
Radix bupleuri: acrid flavour, hardship, cold nature, have and inducing diaphoresis in, be adjutant the effect of soothing liver-qi stagnation.
Radix Paeoniae Alba: it is sweet in flavor, pungent, it is warm-natured and, there is dispersing stagnated hepatoqi, soft liver blood-nourishing, delay in analgesic, the effect of calming the liver and astringing yin, be Make medicine.
River radix paeoniae rubra: bitter, cold nature have the effect of clearing heat and cooling blood, removing blood stasis and acesodyne, to make medicine.
The application method of Chinese medicine composition described in the invention patent is as follows:
The traditional Chinese medicine powder packet that the Chinese medicine composition is prepared into is put into stifling instrument, the Chinese medicinal steaming formed by stifling atomization Gas directly acts on eye, improves ocular cell and blood circulation, dredging the channel, the promoting flow of qi and blood circulation, and the passages through which vital energy circulates for hindering silt is unimpeded, right The significant effect of prevention and treatment myopia and its complication.
Specific embodiment
The present invention is described in further detail below with reference to embodiment, embodiments of the present invention are not limited thereto.
Embodiment 1:
It preferably, include following 22 parts of parts by weight Chinese medicine material FLOS CHRYSANTHEMI ALBA from Haizhou of China, 18 parts of cassia seed, 17 parts of lycium barbarum, radix rehmanniae preparata 12 parts, 12 parts of Radix Rehmanniae, 8 parts of radix bupleuri, 3 parts of Radix Paeoniae Alba, 3 parts of river radix paeoniae rubra, 7 parts of the shell of seaear, 13 parts of semen plantaginis.
Specific preparation method following steps:
(1) it is impregnated respectively 45 minutes with the water of 5-10 degree, drying box is respectively put into after immersion and is dried, dry Hang Bai When chrysanthemum, cassia seed, lycium barbarum, Radix Paeoniae Alba, river radix paeoniae rubra, the shell of seaear, semen plantaginis, the control of drying box temperature is dried ripe in 40-45 degree When ground, Radix Rehmanniae, radix bupleuri, drying box temperature control in 55-60 degree, drying time be 30 minutes, place room temperature after it is spare.
(2) iron pan is heated with mild fire, iron pan is heated to hand to set a sense of warmth on pot being degree, about 170 degrees Celsius of left sides When right, by cassia seed in pot, stir-frying to kind skin pops, the micro- blistering in surface, can be pulverized with hand for degree.
(3) grind respectively, cross 120 meshes, then weigh and mix in proportion, stir evenly, it is canned enter 5cm*5cm In non-woven bag, it is prepared into traditional Chinese medicine powder packet.
Specifically used method is as follows:
The Chinese medicine composition is prepared into traditional Chinese medicine powder packet to be put into stifling instrument, the Chinese medicine steam formed by stifling atomization Directly act on eye.
Clinical observation on the therapeutic effect:
(1) general information
Selection of clinical patient 360, wherein male 180, female 180, wherein 5-15 years old 90,15-30 years old 90,30- 45 years old 90,45-60 years old 90.
(2) diagnostic criteria
Effective: eyesight promotes effect, and observes 2-3 months without rebound person.
Improve: eyesight is slightly promoted, and can not be deteriorated in existing eyesight level.
It is invalid: invalid after use.
(3) treatment method
Embodiment 1 made of traditional Chinese medicine powder packet, be put into stifling instrument, early daily, evening is respectively stifling primary to patient, Stifling preceding replacement traditional Chinese medicine powder packet every time, 30 days as one therapeutic course.
(4) treatment results
For 360 clinical samples, using embodiment 1 made of traditional Chinese medicine powder packet, after carrying out fumigation treatment: effective 255, obvious effective rate 70.8%;It improves 98, improvement rate 27.2%;Invalid 7, inefficiency 1.9%.
Typical case is as follows:
Case 1: week not certain, female, 5.5 years old, left eye: 0.2, right eye: 0.5-1, once used Chinese medicine eye ointment smeared treatment, effect It is unobvious, after one course for the treatment of of product of embodiment 1, left eye: 0.8, right eye: 1.0;At the end of three courses for the treatment of, left eye: 1.0, Right eye: 1.1;Eyes reach 1.2 after continuing to use three courses for the treatment of, have been discontinued 2 years, anopsia rebound sign, without bad anti- It answers.
Case 2: Liu, female 16 years old, two former eyesights were 0.5, and with instrument training eyesight, eyesight is anti-later for a period of time And 0.4 is dropped to, after three courses for the treatment of of product of embodiment 1, vision restoration to 0.8, after continuing to use three courses for the treatment of, eyesight is extensive It is multiple to be discontinued 3 years to 1.1, anopsia rebound sign has no adverse reaction.
Case 3: Zhang, female 31 years old, binocular vision 0.4 once did myopia laser before and performed the operation, but eyesight after 2 years Rebound, binocular vision have been returned to 0.4, and after six courses for the treatment of of product of embodiment 1, binocular vision all reaches 0.7, at present Still in active treatment.
Case 4: Xu so-and-so, female 47 years old, binocular vision 0.5 continued nearly 28 years of myopia, and eye drops is used for a long time, makes After six courses for the treatment of of product of embodiment 1, binocular vision all reaches 0.8, has stopped treating due to personal.
Certainly, there are also other a variety of cases to be familiar with without deviating from the spirit and substance of the present invention by the present invention One of skill in the art makes various corresponding adjustment in accordance with the present invention, but these corresponding variations all should belong to this hair Bright protection scope.

Claims (4)

1. a kind of prevention and treatment myopia and its Chinese medicine composition of complication and preparation method thereof, which is characterized in that matched by following weight The Chinese medicine material of ratio is prepared: 20-25 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China, 15-20 parts of cassia seed, 15-20 parts of lycium barbarum, 10-15 parts of radix rehmanniae preparata, 10-15 parts of Radix Rehmanniae, 5-10 parts of radix bupleuri, 1-5 parts of Radix Paeoniae Alba, radix paeoniae rubra 1-5 parts of river.
2. Chinese medicine composition according to claim 1, which is characterized in that further include the Chinese medicine material shell of seaear of weight proportion 5-10 parts, 10-15 parts of semen plantaginis.
3. Chinese medicine composition according to claim 1, it is characterised in that following preparation method:
(1) it is impregnated respectively 45 minutes with the water of 5-10 degree, drying box is respectively put into after immersion and is dried, drying FLOS CHRYSANTHEMI ALBA from Haizhou of China is determined When pine torch, lycium barbarum, Radix Paeoniae Alba, river radix paeoniae rubra, the control of drying box temperature dries radix rehmanniae preparata, Radix Rehmanniae, radix bupleuri, Shi Jue in 40-45 degree When bright, semen plantaginis, drying box temperature is controlled in 55-60 degree, drying time be 30 minutes, place spare after room temperature.
(2) iron pan is heated with mild fire, iron pan is heated to hand and sets on pot a sense of warmth as degree, when about 170 degrees centigrade, By cassia seed in pot, stir-frying to kind skin pops, the micro- blistering in surface, can be pulverized with hand for degree.
(3) grind respectively, cross 120 meshes, then weigh and mix in proportion, stir evenly, it is canned enter 5cm*5cm nonwoven In cloth bag, traditional Chinese medicine powder packet is formed.
4. Chinese medicine composition according to claim 1, it is characterised in that following application method:
The traditional Chinese medicine powder packet that the Chinese medicine composition is prepared into is put into stifling instrument, the Chinese medicine steam formed by stifling atomization is straight It connects and acts on eye, improve ocular cell and blood circulation, dredging the channel, the promoting flow of qi and blood circulation, the passages through which vital energy circulates for hindering silt is unimpeded, to prevention and treatment The significant effect of myopia and its complication.
CN201910601720.6A 2019-07-05 2019-07-05 A kind of prevention and treatment myopia and its Chinese medicine composition of complication and preparation method thereof Pending CN110179890A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101647908A (en) * 2009-09-27 2010-02-17 贾晓萍 Chinese traditional medicine for treating eyesight and preparation method and use method thereof
CN102028817A (en) * 2009-09-24 2011-04-27 于丽文 Externally applied drug for preventing and treating myopia and amblyopia and using method of drug
CN104689107A (en) * 2015-02-10 2015-06-10 潘雄峰 Traditional Chinese medicine for treating nearsightedness and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102028817A (en) * 2009-09-24 2011-04-27 于丽文 Externally applied drug for preventing and treating myopia and amblyopia and using method of drug
CN101647908A (en) * 2009-09-27 2010-02-17 贾晓萍 Chinese traditional medicine for treating eyesight and preparation method and use method thereof
CN104689107A (en) * 2015-02-10 2015-06-10 潘雄峰 Traditional Chinese medicine for treating nearsightedness and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王勇: "《古今中医效验秘方宝典 精选古今文献中的效验秘方》", 31 January 2017, 天津:天津科学技术出版社 *

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Application publication date: 20190830