CN110179689A - A kind of liniment based on gene recombinant protein Ta-hMsrA - Google Patents
A kind of liniment based on gene recombinant protein Ta-hMsrA Download PDFInfo
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- CN110179689A CN110179689A CN201910436511.0A CN201910436511A CN110179689A CN 110179689 A CN110179689 A CN 110179689A CN 201910436511 A CN201910436511 A CN 201910436511A CN 110179689 A CN110179689 A CN 110179689A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of liniments based on gene recombinant protein Ta-hMsrA, it include gene recombinant protein Ta-hMsrA, the each component quality proportioning of the liniment includes: glycerol 5~35%, trehalose 1~5%, 0.5~3.5% gelling agent, 0.5~5% gene recombinant protein Ta-hMsrA, 0.1~1% surfactant, and surplus is emulsified bases and water.The present invention has effects that crease-resistant, anti-oxidant, removing free radical, and can preferably keep the activity of gene recombinant protein Ta-hMsrA, has huge market prospects.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of liniment based on gene recombinant protein Ta-hMsrA.
Background technique
A large amount of modern neuros scientific investigations showed that, the pathology damage of Mediated by Free Radicals participates in a variety of great diseases of nervous system
The occurrence and development of disease.Brain lipid content abundant and the opposite antioxidant enzyme levels lacked are easier to it in oxidative stress
It is impaired.Many factors (such as abnormal folded protein accumulation, ischemical reperfusion injury) are lured by approach such as mitochondria aerobic respiration
It leads neuron and generates more active oxygens (ROS), such as O2-.、H2O2, OH and1O2, and be often accompanied by ROS in aging course and remove system
It unites the decrease of (such as glutathione reducing system, superoxide dismutase), so as to cause the different of oxygen radical or oxidation product
Often accumulation causes the generation of nervous system major disease.
Methionine sulfoxide reductase A (methionine sulfoxide reductase A, MsrA) is presently found
The main antioxidant enzyme system for reversing protein methionine residue oxidation structure variation and function damage can be restored in vivo.
MsrA has hair into plant and mammal in many organisms, from archeobacteria Escherichia coli very ancient in evolution
Existing, antioxidation has especially important meaning for the existence of organism.A large number of studies show that MsrA is a kind of presence
Anti-oxidant reparative factor in organism.Human T-cell caused by oxidative stress, people can significantly be mitigated by being overexpressed MsrA gene
Lens cell, PC12 cell and the isocellular damage of WI-38SV40 and apoptosis.There is research to think, MsrA and aging and lactation are moved
The object service life is closely related.Therefore, the gene expression for adjusting MsrA to anti-aging and crease-resistant can play preferable effect.
Chinese patent " CN101974089B ", which discloses fusion, has TAT protein transduction structural domain and humanized's methionine sub-
Sulfoxide reductase hMsrA and sulphur hydrogen reduction albumen Trx are formed by fusion protein and preparation method thereof and in neurocyte protection
The application of aspect.But the preparation of above-mentioned albumen only resides within laboratory stage at present, scale volume production is difficult, and has
Body is applied to cosmetics or medicine field, saves and activity keeps highly difficult.
Summary of the invention
The present invention for the technical problems in the prior art, provides a kind of based on gene recombinant protein Ta-hMsrA's
Liniment has effects that crease-resistant, anti-oxidant, removing free radical, and can preferably keep gene recombinant protein Ta-hMsrA
Activity, have huge market prospects.
The technical scheme to solve the above technical problems is that a kind of wiping based on gene recombinant protein Ta-hMsrA
Agent, includes gene recombinant protein Ta-hMsrA, and each component quality proportioning of the liniment includes: glycerol 5~35%, trehalose
1~5%, 0.5~3.5% gelling agent, 0.5~5% gene recombinant protein Ta-hMsrA, 0.1~1% surfactant, surplus
For emulsified bases and water.
The beneficial effects of the present invention are: product of the present invention contains gene recombinant protein Ta-hMsrA, have anti-oxidant, anti-
Multiple efficacies, the sp acts such as wrinkle, reduction melanin, firm skin can effectively eliminate the free radical of human skin, repair
Lead to the cell of damage because of oxidation；Meanwhile product of the present invention further includes the glycerol, trehalose and a small amount of surface of certain content
The collective effect of activating agent, three can effectively keep the activity of gene recombinant protein Ta-hMsrA under normal temperature conditions can
Ensure that gene recombinant protein Ta-hMsrA all has activity in a long time, convenient for the transport and preservation of product of the present invention.
Based on the above technical solution, the present invention can also be improved as follows.
Further, the content preferably 2~4% of the gene recombinant protein Ta-hMsrA.
Beneficial effect using above-mentioned further scheme is to can effectively ensure that human body can be right using above-mentioned additive amount
The Transdermal absorption of gene recombinant protein Ta-hMsrA avoids additive amount excessive, causes human body that can not fully absorb and waste；Together
When, above-mentioned additive amount can ensure that human body takes in enough gene recombinant protein Ta-hMsrA, participate in oxidation reaction, repair simultaneously
Damaged tissues.
Further, one of the preferred carbomer of the gelling agent, reed fragrant plant glue, propylene glycol and polysorbate.
Beneficial effect using above-mentioned further scheme is that above-mentioned gelling agent is nontoxic, good at colloidality, to skin without sensitization,
It is nonirritant.
Further, the preferred Cocoamidopropyl betaine of the surfactant, lauric acid and dodecyl polyethylene glycol
One of ether；The content of the trehalose preferably 2~3%, the content of the surfactant preferably 0.1~0.2%.
Beneficial effect using above-mentioned further scheme is nontoxic to skin, non-stimulated using above-mentioned surfactant；Together
When, above-mentioned surfactant has preferable dispersion effect to gene recombinant protein Ta-hMsrA, can effectively avoid albumen solidifying
Knot；Using the adding proportion of preferred trehalose and surfactant, gene recombinant protein Ta-hMsrA can be effectively kept to exist
Activity under room temperature.
Further, the liniment further includes having hyaluronic acid, and the mass percentage content of the hyaluronic acid is 0.001~
0.01%.
Beneficial effect using above-mentioned further scheme is can be effectively improved skin-nourishing metabolism, makes that skin is tender, light
It slides, goes wrinkle, increase elasticity, prevent aging, skin can be promoted to the Transdermal absorption of effective component again while moisturizing.
Further, the mass percentage content of the emulsified bases preferably 10~20%.
Beneficial effect using above-mentioned further scheme is can to effectively improve the comfort of product, and reduction used
Sense of discomfort in journey promotes skin to the Transdermal absorption of effective component.
Further, the liniment further includes having watermiscible vitamin E, and the mass percent of the watermiscible vitamin E contains
Amount preferably 0.1~0.5%, most preferably 0.4~0.5%.
Beneficial effect using above-mentioned further scheme is can to further increase anti-oxidant and crease-resistant effect, and prevention is scorching
Disease dermatoses protect the skin from the injury of ultraviolet light and pollution, reduce the deposition of scar and pigment.
Further, the preferred deionized water of the water.
Beneficial effect using above-mentioned further scheme is can to effectively improve the stability of product, while can effectively drop
The low stimulation to skin.
Specific embodiment
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
A kind of liniment based on gene recombinant protein Ta-hMsrA, includes gene recombinant protein designed by the present invention
Ta-hMsrA, each component quality proportioning of the liniment include: glycerol 5~35%, trehalose 1~5%, 0.5~3.5% gel
Agent, 0.5~5% gene recombinant protein Ta-hMsrA, 0.1~1% surfactant, surplus are emulsified bases and water.The base
Because of the content preferably 2~4% of recombinant protein Ta-hMsrA.
Gene recombinant protein Ta-hMsrA is core of the invention ingredient, with anti-oxidant, crease-resistant, reduction melanin, tightly
The multiple efficacies such as skin are caused, sp act can effectively eliminate the free radical of human skin, and reparation causes to damage because of oxidation
Cell.Gene recombinant protein Ta-hMsrA used in the present invention can use Publication No. " CN101974089A ", title
Content to record in " recombination Trx-TAT-hMsrA fusion protein and its application in terms of neurocyte protection " obtains Trx-
TAT-hMsrA fusion protein is then obtained through enterokinase digestion removal " Trx ".
The application difficult point of gene recombinant protein Ta-hMsrA is that protein active is difficult to keep, can using the form of freeze-dried powder
To keep its activity, but it is difficult in medicine adornment and cosmetics.Therefore gene recombinant protein Ta-hMsrA be applied to medicine adornment and
Maximum difficult point is to need to make albumen can keep higher activity for a long time under normal temperature conditions in cosmetics.
Present invention auxiliary is added to: glycerol 5~35%, the surfactant of trehalose 1~5% and 0.1~1%.Can have
Effect solves the problems, such as that gene recombinant protein Ta-hMsrA keeps activity.
Trehalose has magical protective effect to organism, is because trehalose is in high temperature, high and cold, hyperosmosis and does
Unique protective film can be formed in cell surface under the severe environmental conditions such as dry dehydration, is effectively protected protein molecule invariance
Inactivation, thus the life process and biological characteristic of the body that sustains life.This unique functional characteristic, so that trehalose is in addition to can be with
Excellent activity protective agent as pharmaceutical grade protein, enzyme, vaccine and other biological product.And gene recombinant protein Ta-hMsrA
Matter is very unstable, is difficult to keep its activity merely by trehalose, inventor is adjusted in any case by test discovery for a long time
The additive amount of trehalose, all it is difficult to ensure that gene recombinant protein Ta-hMsrA keeps activity at normal temperature for a long time.
Inventor has found after furtheing investigate to this, cause gene recombinant protein Ta-hMsrA inactivation mainly there are two because
Element influences: being that the albumen is easier to be condensed into blocks first, leads to deactivation；Followed by the albumen influences environmental stimuli and environment
React more sensitive, a little environmental stimuli and environment influence can all cause it to lose activity.Inventor after constantly testing by sending out
It is existing, using glycerol as moisturizing and ambient stable agent, and be added after a small amount of surfactant can preferably solve it is above-mentioned two
The influence of factor.Therefore, present invention determine that with 5~35% glycerol, 1~5% trehalose and 0.1~1% surfactant work
Active retention agent for product auxiliary material, as gene recombinant protein Ta-hMsrA.Meanwhile main original of the glycerol as cosmetics
Material, moreover it is possible to play the effect of moisturizing.
Based on above-mentioned consideration, while based on the considerations of safety and sensitization.The preferred carbomer of gelling agent of the invention, reed
One of fragrant plant glue, propylene glycol and polysorbate.The preferred Cocoamidopropyl betaine of surfactant, lauric acid and dodecane
One of base polyglycol ether.The content of the trehalose preferably 2~3%, the content of the surfactant preferably 0.1~
0.2%.The mass percentage content of the emulsified bases preferably 10~20%.The preferred deionized water of water.
In order to further increase moisturizing, the anti-wrinkle effect of product of the present invention, the present invention can also include hyaluronic acid, institute
The mass percentage content for stating hyaluronic acid is 0.001~0.01%.
In order to further increase the oxidation resistant effect of product of the present invention, the present invention can also include watermiscible vitamin E,
The mass percentage content of the watermiscible vitamin E preferably 0.1~0.5%, most preferably 0.4~0.5%.
Embodiment 1
(1) configuration of lotion: the common emulsified bases of cosmetics is add to deionized water according to conventional ratio, is stirred
Mixing is mixed, is mixed, lotion is formed.
(2) the first of liniment is matched: adding said components according to the proportion of glycerol 5%, trehalose 1%, surfactant 0.1%
It is added in lotion, water supplement to formula ratio is stirred, mixes.
(3) configuration of liniment: 0.5% gene recombinant protein Ta-hMsrA freeze-dried powder is added in the liniment just matched, vibration
Mixing is swung, is shaken up；Then 3.5% gelling agent is added, oscillation mixing shakes up, liniment finished product is made after plastic.
Embodiment 2
(1) configuration of lotion: the common emulsified bases of cosmetics being added in purified water, is stirred, and is mixed, and is formed
Lotion.
(2) the first of liniment is matched: on the basis of emulsified bases mass percentage 10%, with glycerol 35%, trehalose
2%, said components are added in lotion by the proportion of surfactant 0.4%, and water supplement to formula ratio is stirred, mixes.
(3) configuration of liniment: 1.5% gene recombinant protein Ta-hMsrA freeze-dried powder is added in the liniment just matched, vibration
Mixing is swung, is shaken up；Then 0.5% gelling agent is added, oscillation mixing shakes up, liniment finished product is made after plastic.
Embodiment 3
(1) configuration of lotion: the common emulsified bases of cosmetics being added in purified water, is stirred, and is mixed, and is formed
Lotion.
(2) the first of liniment is matched: on the basis of emulsified bases mass percentage 15%, with glycerol 30%, trehalose
4%, said components are added in lotion by the proportion of surfactant 0.8%, and water supplement to formula ratio is stirred, mixes.
(3) configuration of liniment: 3.5% gene recombinant protein Ta-hMsrA freeze-dried powder is added in the liniment just matched, vibration
Mixing is swung, is shaken up；Then 1.5% gelling agent is added, oscillation mixing shakes up, liniment finished product is made after plastic.
Embodiment 4
(1) configuration of lotion: the common emulsified bases of cosmetics being added in purified water, is stirred, and is mixed, and is formed
Lotion.
(2) the first of liniment is matched: on the basis of emulsified bases mass percentage 20%, with glycerol 20%, trehalose
5%, said components are added in lotion by the proportion of surfactant 1%, and water supplement to formula ratio is stirred, mixes.
(3) configuration of liniment: 5% gene recombinant protein Ta-hMsrA freeze-dried powder is added in the liniment just matched, oscillation
Mixing, shakes up；Then 2.5% gelling agent is added, oscillation mixing shakes up, liniment finished product is made after plastic.
Embodiment 5
(1) configuration of lotion: the common emulsified bases of cosmetics being added in purified water, is stirred, and is mixed, and is formed
Lotion.Emulsified bases can using dimethyl silicone polymer as major ingredient, be aided in stearyl alcohol, glycerin monostearate and tween one
Kind or several be mixed to get.
(2) the first of liniment is matched: on the basis of emulsified bases mass percentage 10%, with glycerol 10%, trehalose
2%, Cocoamidopropyl betaine 0.3%, hyaluronic acid 0.001% proportion said components are added in lotion, add
Water is stirred, mixes to formula ratio.
(3) configuration of liniment: 2% gene recombinant protein Ta-hMsrA freeze-dried powder is added in the liniment just matched, oscillation
Mixing, shakes up；Then 2.5% carbomer is added, oscillation mixing shakes up, liniment finished product is made after plastic.
Embodiment 6
(1) configuration of lotion: the common emulsified bases of cosmetics being added in purified water, is stirred, and is mixed, and is formed
Lotion.Emulsified bases can using dimethyl silicone polymer as major ingredient, be aided in stearyl alcohol, glycerin monostearate and tween one
Kind or several be mixed to get.
(2) the first of liniment is matched: on the basis of emulsified bases mass percentage 15%, with glycerol 15%, trehalose
2%, Brij-35 0.15%, hyaluronic acid 0.003% proportion said components are added in lotion, add
Water is stirred, mixes to formula ratio.
(3) configuration of liniment: 2.5% gene recombinant protein Ta-hMsrA freeze-dried powder is added in the liniment just matched, vibration
Mixing is swung, is shaken up；Then 1.5% reed fragrant plant glue is added, oscillation mixing shakes up, liniment finished product is made after plastic.
Embodiment 7
(1) configuration of lotion: the common emulsified bases of cosmetics being added in purified water, is stirred, and is mixed, and is formed
Lotion.Emulsified bases can using dimethyl silicone polymer as major ingredient, be aided in stearyl alcohol, glycerin monostearate and tween one
Kind or several be mixed to get.
(2) the first of liniment is matched: on the basis of emulsified bases mass percentage 20%, with glycerol 10%, trehalose
3%, the proportion of Brij-35 0.2%, watermiscible vitamin E 0.2%, hyaluronic acid 0.006% is by above-mentioned group
Divide and be added in lotion, water supplement to formula ratio is stirred, mixes.
(3) configuration of liniment: 3.5% gene recombinant protein Ta-hMsrA freeze-dried powder is added in the liniment just matched, vibration
Mixing is swung, is shaken up；Then 2% propylene glycol is added, oscillation mixing shakes up, liniment finished product is made after plastic.
Embodiment 8
(1) configuration of lotion: the common emulsified bases of cosmetics being added in purified water, is stirred, and is mixed, and is formed
Lotion.Emulsified bases can using dimethyl silicone polymer as major ingredient, be aided in stearyl alcohol, glycerin monostearate and tween one
Kind or several be mixed to get.
(2) the first of liniment is matched: on the basis of emulsified bases mass percentage 15%, with glycerol 20%, trehalose
2.5%, lauric acid 0.1%, watermiscible vitamin E 0.1%, hyaluronic acid 0.008% proportion said components are added to cream
In liquid, water supplement to formula ratio is stirred, mixes.
(3) configuration of liniment: 4% gene recombinant protein Ta-hMsrA freeze-dried powder is added in the liniment just matched, oscillation
Mixing, shakes up；Then 3.5% polysorbate is added, oscillation mixing shakes up, liniment finished product is made after plastic.
Embodiment 9
(1) configuration of lotion: the common emulsified bases of cosmetics being added in purified water, is stirred, and is mixed, and is formed
Lotion.Emulsified bases can using dimethyl silicone polymer as major ingredient, be aided in stearyl alcohol, glycerin monostearate and tween one
Kind or several be mixed to get.
(2) the first of liniment is matched: on the basis of emulsified bases mass percentage 15%, with glycerol 12%, trehalose
2%, the proportion of Brij-35 0.1%, watermiscible vitamin E 0.5%, hyaluronic acid 0.002% is by above-mentioned group
Divide and be added in lotion, water supplement to formula ratio is stirred, mixes.
(3) configuration of liniment: 2.5% gene recombinant protein Ta-hMsrA freeze-dried powder is added in the liniment just matched, vibration
Mixing is swung, is shaken up；Then 1% carbomer is added, oscillation mixing shakes up, liniment finished product is made after plastic.
Embodiment 10
(1) configuration of lotion: the common emulsified bases of cosmetics being added in purified water, is stirred, and is mixed, and is formed
Lotion.Emulsified bases can using dimethyl silicone polymer as major ingredient, be aided in stearyl alcohol, glycerin monostearate and tween one
Kind or several be mixed to get.
(2) the first of liniment is matched: on the basis of emulsified bases mass percentage 10%, with glycerol 15%, trehalose
3%, the proportion of Brij-35 0.2%, watermiscible vitamin E 0.4%, hyaluronic acid 0.01% is by above-mentioned group
Divide and be added in lotion, water supplement to formula ratio is stirred, mixes.
(3) configuration of liniment: 3.5% gene recombinant protein Ta-hMsrA freeze-dried powder is added in the liniment just matched, vibration
Mixing is swung, is shaken up；Then 1.5% reed fragrant plant glue is added, oscillation mixing shakes up, liniment finished product is made after plastic.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of liniment based on gene recombinant protein Ta-hMsrA, which is characterized in that include gene recombinant protein Ta-
HMsrA, each component quality proportioning of the liniment include: glycerol 5~35%, trehalose 1~5%, 0.5~3.5% gelling agent,
0.5~5% gene recombinant protein Ta-hMsrA, 0.1~1% surfactant, surplus are emulsified bases and water.
2. a kind of liniment based on gene recombinant protein Ta-hMsrA according to claim 1, it is characterised in that: the gene
The content of recombinant protein Ta-hMsrA is 2~4%.
3. a kind of liniment based on gene recombinant protein Ta-hMsrA according to claim 1, it is characterised in that: the gel
Agent is one of carbomer, reed fragrant plant glue, propylene glycol and polysorbate.
4. a kind of liniment based on gene recombinant protein Ta-hMsrA according to claim 1, it is characterised in that: the surface
Activating agent is one of Cocoamidopropyl betaine, lauric acid and Brij-35.
5. a kind of liniment based on gene recombinant protein Ta-hMsrA according to claim 1, it is characterised in that: the seaweed
The content of sugar is 2~3%, and the content of the surfactant is 0.1~0.2%.
6. a kind of liniment based on gene recombinant protein Ta-hMsrA according to claim 1, it is characterised in that: the liniment
It further include having hyaluronic acid, the mass percentage content of the hyaluronic acid is 0.001~0.01%.
7. a kind of liniment based on gene recombinant protein Ta-hMsrA according to claim 1, it is characterised in that: the emulsification
The mass percentage content of matrix is 10~20%.
8. a kind of liniment based on gene recombinant protein Ta-hMsrA according to claim 1, it is characterised in that: the liniment
It further include having watermiscible vitamin E, the mass percentage content of the watermiscible vitamin E is 0.1~0.5%.
9. a kind of liniment based on gene recombinant protein Ta-hMsrA according to claim 6, it is characterised in that: described water-soluble
Property vitamin E mass percentage content be 0.4~0.5%.
10. a kind of liniment based on gene recombinant protein Ta-hMsrA described in any one according to claim 1~9, special
Sign is: the water is deionized water.
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Cited By (1)
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| CN101974089A (en) * | 2010-06-11 | 2011-02-16 | 华中科技大学 | Recombination fusion protein Trx-TAT-hMsrA and application thereof to aspect of nerve cell protection |
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Cited By (1)
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|---|---|---|---|---|
| CN111110585A (en) * | 2019-12-31 | 2020-05-08 | 武汉华肽生物科技有限公司 | Hair-blacking composition based on gene recombinant protein Tat-hMsrA and application thereof |
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