CN110170013A - A kind of draft emulsifiable paste and preparation method thereof for treating wind-heat cough and asthma - Google Patents

A kind of draft emulsifiable paste and preparation method thereof for treating wind-heat cough and asthma Download PDF

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Publication number
CN110170013A
CN110170013A CN201910436874.4A CN201910436874A CN110170013A CN 110170013 A CN110170013 A CN 110170013A CN 201910436874 A CN201910436874 A CN 201910436874A CN 110170013 A CN110170013 A CN 110170013A
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parts
draft
emulsifiable paste
asthma
wind
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刘金权
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Sichuan Jin Huiai Health Management Co Ltd
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Sichuan Jin Huiai Health Management Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884—Arisaema, e.g. Jack in the pulpit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

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Abstract

The invention discloses a kind of draft emulsifiable pastes and preparation method thereof for treating wind-heat cough and asthma, including following component by weight: 25-35 parts of the root of Dahurain angelica, 6-15 parts of asarum, 10-16 parts of semen armeniacae amarae, 2-12 parts of gypsum, 8-13 parts of arisaema cum bile, 4-10 parts of pheretima, it is campanulaceae 7-20 parts wide, a kind of reed mentioned in ancient books 5-15 parts withered, 3-8 parts of chrysanthemum.The present invention is used to be applied with by the way that emulsifiable paste is made in draft Chinese medicine, eliminates the inconvenience of patient's medication, and is targetedly applied with, treating both manifestation and root cause of disease, so that emulsifiable paste is quick, good effect, effective percentage up to 95%.

Description

A kind of draft emulsifiable paste and preparation method thereof for treating wind-heat cough and asthma
Technical field
The invention belongs to traditional Chinese medicine emulsifiable paste technical fields, and in particular to a kind of draft emulsifiable paste for treating wind-heat cough and asthma and its preparation Method.
Background technique
Wind-heat cough and asthma is experienced the heresy of wind-heat, cough caused by lung qi obstruction by body.Because ferritic fire is contained, or feel outside wind-heat Heresy, attacking the lung first, lung qi obstruction, heat refining body fluid are shown in cough at phlegm, and expectoration Huang is thick, dry；The heresy of wind-heat invades fleshy exterior, defends Sun is held back, and heresy just disaccords, therefore fever with adversion to wind；The main catharsis of wind, wind-heat violate table, and fur opening of sweat pores is let out, therefore perspire；Wind-heat troubling is smoked Throat is steamed, therefore pharyngalgia of having a headache；Thin lingual fur is yellow, superficial and rapid pulse, for wind-heat invade in lung defend as.
The drug for the treatment of wind-heat cough and asthma is various at present, and mainly Western medicine and Chinese patent drug, western medicine class are Chemical composition thats, mainly It is treated using antiviral, antipyretic-antalgic and antibiotic, the curative effect that do not eradicate, the state of an illness is easy repeatedly, and there are certain pairs Effect；And Chinese patent drug is then plurality of Chinese to be crushed molding to be made, and Chinese patent drug is a lot of to the effect of prevention, therapeutic effect is not Obviously, and slow curative effect.
It is existing treatment wind-heat cough and asthma drug be substantially it is oral, the oral of Western medicine is easy to cause tablet to cover when oral Trunnion causes discomfort to pill taker；Since Chinese patent drug is mostly that traditional Chinese medicine forms, Chinese patent drug is mostly bitter, to cause Majority do not like.
Summary of the invention
The technical problems to be solved by the invention are in view of the above shortcomings of the prior art, to provide and a kind of treat wind-heat cough Draft emulsifiable paste of asthma and preparation method thereof, the draft emulsifiable paste are formulated using pure Chinese medicine, traditional oral medication are changed to Application treatment avoids oral drugs to discomfort caused by pill taker, while using Chinese medicine application, and quick, good effect can reach To the purpose of radical cure.
The technical scheme adopted by the invention is that: a kind of draft emulsifiable paste that treating wind-heat cough and asthma, including by weight Following component: 25-35 parts of the root of Dahurain angelica, 6-15 parts of asarum, 10-16 parts of semen armeniacae amarae, 2-12 parts of gypsum, 8-13 parts of arisaema cum bile, pheretima 4- 10 parts, it is campanulaceae 7-20 parts wide, a kind of reed mentioned in ancient books 5-15 parts withered, 3-8 parts of chrysanthemum.
Preferably, the wind-heat cough and asthma draft emulsifiable paste includes 10 parts of 30 parts of the root of Dahurain angelica, asarum, semen armeniacae amarae by weight 10 parts, 10 parts of gypsum, 10 parts of arisaema cum bile, 10 parts of pheretima, 10 parts of wide campanulaceae, 10 parts of withered a kind of reed mentioned in ancient books, 6 parts of chrysanthemum.
A kind of preparation method of draft emulsifiable paste that treating wind-heat cough and asthma, comprising the following steps:
(1) root of Dahurain angelica, asarum, semen armeniacae amarae, gypsum, arisaema cum bile, pheretima, wide campanulaceae, withered a kind of reed mentioned in ancient books, chrysanthemum are chosen according to the ratio；
(2) raw material of selection is crushed, crush temperature be 0-10 DEG C, grinding time 25-30min, it is smashed Hybrid particles mesh number is 280-320 mesh；
(3) smashed hybrid particles are emulsified, emulsifying temperature control is at 60-75 DEG C, emulsification times 30- 60min treats the draft emulsifiable paste of wind-heat cough and asthma after emulsification.
Preferably, the speed of agitator in step (3) in emulsion process is controlled in 40-60r/min.
The root of Dahurain angelica: property is acrid in flavour and warm in nature；Enter lung, spleen, stomach meridian；For wind-dispelling, eliminating dampness is reduced swelling, analgesic.Control headache, pain in the supra-orbital bone, tooth Bitterly, nasosinusitis, cold-dampness stomachache, intestines wind anal fistula, leukorrhea with reddish discharge, ulcer sores, skin itchy, scabies；
Asarum: it is acrid in flavour and warm in nature, it is slightly poisonous.Relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping is sensible, warming lung and resolving fluid.Anemofrigid cold is had a headache, toothache, Rheumatic arthralgia, nasosinusitis, lung cold cough；
Semen armeniacae amarae: main cough with dyspnea is thunderous, sore throat, lower gas, galactopoiesis metal-inflicted wound, bitterly disappointed renal mass；For cough and asthma, fullness sensation in chest phlegm More, deficiency of blood saliva is withered, dry constipation of intestines；
Gypsum: it is cool in nature, it is clearing heat and detoxicating.With the root of Dahurain angelica, clearing heat-fire, swelling and pain relieving；
Arisaema cum bile: bitter, micro-pungent, it is cool.Return lung, liver, the spleen channel.Clearing heat and eliminating phlegm, dispelling wind and relieving convulsion.For phlegm-heat cough, Huang of coughing up phlegm It is thick, stroke and phlegm confusing heart, demented frightened epilepsy；
Pheretima: its is cold in nature, taste is salty, and heat-clearing arresting convulsion, dysmenorrhea is active, diuresis of relievining asthma；For cerebral thrombosis, cerebral infarction, coronary heart disease, Apoplexy, joint paralysis, extremity numbness, hemiplegia, the illnesss such as vascular hypertension；
Wide campanulaceae: wide campanulaceae, antibechic, expectorant.Promoting the dispersing function of the lung, relieving sore-throat, eliminating the phlegm, apocenosis.For coughing with a lot of sputum, chest distress, Pharyngalgia, hoarse voice, lung carbuncle pyemesis, sore purulence at；
Withered a kind of reed mentioned in ancient books: bitter, it is cold in nature.Return lung, gallbladder, spleen, large intestine, small intestinl channel.Heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis；
Chrysanthemum: bitter, sweet, cold nature.Relieve heat heat-clearing, calming the liver and improving eyesight are clearing heat and detoxicating.
The beneficial effects of the present invention are:
(1) it is used to be applied with by the way that emulsifiable paste is made in draft Chinese medicine, eliminates the inconvenience of patient's medication, and first cross is avoided to imitate It answers and the peak valley phenomenon of oral medicine and half-life period influences；
(2) it is directed to wind-heat cough and asthma, emulsifiable paste is applied at corresponding acupuncture point, emulsifiable paste pharmacological property enters acupuncture point relevant to wind-heat cough and asthma In, it is targetedly applied with, so that emulsifiable paste is quick, good effect, there is no any side effects, can be applied with for a long time.
The present invention is formed using draft drug matching, and is targetedly applied with, treating both manifestation and root cause of disease, has good treatment Effect, effective percentage up to 95%.
Specific embodiment
Below in conjunction with specific embodiment, invention is further described in detail.
Embodiment 1
The draft emulsifiable paste for the treatment of wind-heat cough and asthma provided in this embodiment, is prepared by following steps:
(1) 30 parts of the root of Dahurain angelica, 10 parts of asarum, 10 parts of semen armeniacae amarae, 10 parts of gypsum, 10 parts of arisaema cum bile, pheretima are chosen by weight 10 parts, 10 parts of wide campanulaceae, 10 parts of withered a kind of reed mentioned in ancient books, 6 parts of chrysanthemum；
(2) raw material of selection is crushed, crush temperature be 8 DEG C, grinding time 28min, smashed mixing Grain mesh number is 320 mesh；
(3) smashed hybrid particles are emulsified, emulsifying temperature controls the emulsification at 60 DEG C, emulsification times 45min The speed of agitator of emulsifying homogeneous machine controls the draft emulsifiable paste that wind-heat cough and asthma is treated after 45r/min, emulsification in the process.
Embodiment 2
The draft emulsifiable paste for the treatment of wind-heat cough and asthma provided in this embodiment, is prepared by following steps:
(1) 32 parts of the root of Dahurain angelica, 15 parts of asarum, 12 parts of semen armeniacae amarae, 4 parts of gypsum, 9 parts of arisaema cum bile, pheretima 8 are chosen by weight Part, 16 parts of wide campanulaceae, 5 parts of withered a kind of reed mentioned in ancient books, 4 parts of chrysanthemum；
(2) raw material of selection is crushed, crush temperature be 3 DEG C, grinding time 28min, smashed mixing Grain mesh number is 300 mesh；
(3) smashed hybrid particles are emulsified, emulsifying temperature controls the emulsification at 68 DEG C, emulsification times 55min The speed of agitator of emulsifying homogeneous machine controls the draft emulsifiable paste that wind-heat cough and asthma is treated after 50r/min, emulsification in the process.
Embodiment 3
The draft emulsifiable paste for the treatment of wind-heat cough and asthma provided in this embodiment, is prepared by following steps:
(1) 26 parts of the root of Dahurain angelica, 8 parts of asarum, 15 parts of semen armeniacae amarae, 8 parts of gypsum, 12 parts of arisaema cum bile, pheretima 4 are chosen by weight Part, 8 parts of wide campanulaceae, 14 parts of withered a kind of reed mentioned in ancient books, 8 parts of chrysanthemum；
(2) raw material of selection is crushed, crush temperature be 8 DEG C, grinding time 30min, smashed mixing Grain mesh number is 320 mesh；
(3) smashed hybrid particles are emulsified, emulsifying temperature controls the emulsification at 72 DEG C, emulsification times 35min The speed of agitator of emulsifying homogeneous machine controls the draft emulsifiable paste that wind-heat cough and asthma is treated after 60r/min, emulsification in the process.
The draft emulsifiable paste of present invention treatment wind-heat cough and asthma is externally applied to feishu cave and SHANZHONG acupoint by application method of the invention, Each external application early, middle and late daily is primary, and 3 as a treatment course.
Clinical trial:
(1) clinical data
It is selected in more than 200 example of anemofrigid cold patient altogether and carries out clinical observation, male 108, female 96, the age was at 20-60 years old Between.
(2) diagnostic criteria
The cough mainly shown according to patient, no phlegm, or have phlegm color Huang thick, it is not easy expectoration, dry throat pain, fever, sweat Out, headache, dizzy, tongue is red, moss thin yellow judges；
(3) the draft emulsifiable paste of present invention treatment anemofrigid cold is externally applied to feishu cave and SHANZHONG acupoint by treatment method, early daily, In, evening it is each be applied with primary, 3 are as a treatment course, need two courses for the treatment of, first course for the treatment of is treatment stage, and second stage is Consolidation phase.
(4) efficacy assessment standard
Recovery from illness: the pains such as headache, dizziness, dry throat pain disappear；The symptoms such as cough, dry cough, sweating disappear；
Effective: the symptoms such as headache, dizziness, dry throat pain greatly mitigate alleviation, with a small amount of cough and fever；
Improve: the symptoms such as headache, dizziness, dry throat pain are mitigated, and are faint yellow, hair with a large amount of cough, expectoration Heat, dizziness；
Invalid: the symptoms such as headache, dizziness, dry throat pain still continue, and with cough, phlegm color Huang is thick, dry throat pain, hair The symptoms such as heat, sweating.
(5) treatment results
More than 200 example patients are treated and the later period tracks, improvement rate 100%, obvious effective rate 97.75%, cure rate 92.28%, therapeutic effect is significant.
The above is only the preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, any The transformation and replacement carried out based on technical solution provided by the present invention and inventive concept should all be covered in protection model of the invention In enclosing.

Claims (4)

1. a kind of draft emulsifiable paste for treating wind-heat cough and asthma, it is characterised in that: including following component by weight: root of Dahurain angelica 25- 35 parts, 6-15 parts of asarum, 10-16 parts of semen armeniacae amarae, 2-12 parts of gypsum, 8-13 parts of arisaema cum bile, 4-10 parts of pheretima, wide campanulaceae 7-20 Part, it is a kind of reed mentioned in ancient books 5-15 parts withered, 3-8 parts of chrysanthemum.
2. a kind of draft emulsifiable paste for treating wind-heat cough and asthma according to claim 1, it is characterised in that: including by weight 30 parts of the root of Dahurain angelica, 10 parts of asarum, 10 parts of semen armeniacae amarae, 10 parts of gypsum, 10 parts of arisaema cum bile, 10 parts of pheretima, 10 parts of wide campanulaceae, withered a kind of reed mentioned in ancient books 10 Part, 6 parts of chrysanthemum.
3. a kind of preparation method of draft emulsifiable paste for treating wind-heat cough and asthma according to claim 1, it is characterised in that: including Following steps:
(1) root of Dahurain angelica, asarum, semen armeniacae amarae, gypsum, arisaema cum bile, pheretima, wide campanulaceae, withered a kind of reed mentioned in ancient books, chrysanthemum are chosen according to the ratio；
(2) raw material of selection is crushed, crush temperature be 0-10 DEG C, grinding time 25-30min, smashed mixing Particle mesh number is 280-320 mesh；
(3) smashed hybrid particles are emulsified, emulsifying temperature is controlled at 60-75 DEG C, emulsification times 30-60min, cream The draft emulsifiable paste of wind-heat cough and asthma is treated after change.
4. a kind of preparation method of draft emulsifiable paste for treating wind-heat cough and asthma according to claim 3, it is characterised in that: step (3) speed of agitator in emulsion process is controlled in 40-60r/min.
CN201910436874.4A 2019-05-23 2019-05-23 A kind of draft emulsifiable paste and preparation method thereof for treating wind-heat cough and asthma Pending CN110170013A (en)

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