CN110169993A - Complex composition containing Coelomactra antiquata and its preparation method and application - Google Patents

Complex composition containing Coelomactra antiquata and its preparation method and application Download PDF

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CN110169993A
CN110169993A CN201910580276.4A CN201910580276A CN110169993A CN 110169993 A CN110169993 A CN 110169993A CN 201910580276 A CN201910580276 A CN 201910580276A CN 110169993 A CN110169993 A CN 110169993A
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parts
composition containing
coelomactra antiquata
complex composition
coelomactra
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刘克
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
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Abstract

The present invention provides a kind of complex composition containing Coelomactra antiquata, according to parts by weight, including following components: 1-5 parts of Honeysuckle flower, 0.1-1 parts of Chinese rhubarb extract, 1-3 parts of Coelomactra antiquata, 0.1-2 parts of American Ginseng.Can promote the production of body fluid to quench thirst, toxin-expelling and face nourishing, relieving restlessness is refreshed oneself, health takes care of health, the clear kidney gut purge stomach that clear liver but also the anti-hemorrhoid of anti-cancer anti-three are high, commonly use without side-effects.

Description

Complex composition containing Coelomactra antiquata and its preparation method and application
Technical field
The invention belongs to food, drug, health product technology field, more particularly to complex composition containing Coelomactra antiquata and its preparations Method and purposes.
Technical background
Nowadays as life stress is increasing, the daily schedule is unstable, and diet is more and more irregular, easily causes body In sub-health state, the puzzlement of many diseases is faced what is more.
Hemorrhoid are that the one or more that the veniplex under rectum end mucous membrane and under skin of anus occurs varicose and formed is soft Soft venous mass is clinically often divided into internal piles, external piles and mixed hemorrhoid.Hemorrhoid are a kind of common chronic anorectal disease, morbidity Rate is up to 55~75%；And the serious symptoms such as long-term or intermittent hematochezia, rectal tenesmus, pain affect the normal of patient Life.The reason of forming hemorrhoid mainly has the greasy pungent product of more food raw foods, gastrointestinal dysfunction to cause to defecate disturbance of defecation with either dry or loose stool, long Nine rows of station overwork long is sat, and people walks upright, particularly sitting causes anus area to be chronically at high pressure, thrombosis is to be formed The basic reason of hemorrhoid, therefore have the saying of " ten people, nine hemorrhoid, a people just finish hemorrhoid operation ".The method for the treatment of hemorrhoid has hand at present Art, for oral administration or external drug, easy to recur after operation, endo-medicine adverse reaction is more, and external drug (especially Chinese medicine) is controlled It treats hemorrhoid and is increasingly subject to the attention of people since simple and easy to do, adverse reaction is less.
Hypertension (hypertension) refers to that it is main for increasing with systemic arterial blood pressure (systolic pressure and/or diastolic pressure) Feature (systolic pressure >=140 millimetress of mercury, diastolic pressure >=90 millimetress of mercury), can be with the function or device matter of the organs such as the heart, brain, kidney Property damage clinical syndrome.Hypertension is the most common chronic disease and the most important risk factor of cardiovascular and cerebrovascular diseases.Normally The blood pressure of people fluctuates in a certain range with internal and external environment variation.In whole crowd, blood pressure level gradually rises with the age, to receive Contracting pressure becomes apparent, but downward trend is presented in diastolic pressure after 50 years old, and pulse pressure also increases therewith；It is primary in China's high blood pressure Property hypertension accounts for about 90%, and symptomatic hypertension accounts for about 10%, including chronic nephritis, Renal vascular lesions, aortic coaractation, Primary aldosteronism, Cushing's syndrome, pheochromocytoma etc..From the point of view of pathogenic factors, disease incidence height: male's ratio Women is high, and the north is higher than south, and city is higher than rural area, and mental labour is higher than manual labor, and the partially salty ratio of heavy drinking, diet is not Drink drink less, the height that diet is light, it is nervous, the ratio mental relaxation of psychologically upset, psychological balance it is high, have hypertension The ratio of family history is without the high of family history of hypertension.
Hyperlipemia refers to that high cholesterol, three rouge of high glycerine, very low density lipoprotein increase to be reduced with high-density lipoprotein Lipoprotein metabolism abnormality disease.High cholesterol is the range for belonging to hyperlipidemia, and hyperlipidemia is also hyperlipidemia.Hyperlipidemia It is cholesterol, triglycerides and the raising of low-density lipoprotein white level and the high density lipoprotein level in the blood plasma as caused by a variety of causes A kind of a kind of disease of white too low whole body matter metabolic disorder, clinic are divided into I, II, III, IV, V 5 seed types, any in five types One type matter metabolic disorder can all cause certain specific lipoprotein to increase, by the raising for judging which type lipoprotein, so that it may judge It is the hyperlipidemia of which kind, most commonly II familial combined hyperlipidemia.
Hyperglycemia refers to when blood glucose value is higher than normal range (NR).Be fasting blood-glucose normal value in 6.1mmol/L hereinafter, postprandial two The normal value of hour blood glucose is in 7.8mmol/L hereinafter, if being higher than this range, referred to as hyperglycemia.Under normal circumstances, human body energy Enough ensure that the source of blood glucose and outlet keep balancing by hormone control and nerve modulation this two big regulating system, maintains blood glucose In certain level.But inherent cause (such as Diabetes family history) and environmental factor (such as unreasonable diet, obesity) Under collective effect, two big regulatory functions get muddled, and just will appear the raising of blood glucose level.Blood glucose rise, glucose in urine increase, and can draw Osmotic diuresis is sent out, so as to cause the symptom of diuresis；Blood glucose rise, large quantity of moisture are lost, and blood osmotic pressure also can be increased accordingly, high Blood seep can Hypothalamic Stimulation thirst center, so as to cause symptom that is thirsty, more drinking；It is lacked since insulin is opposite or absolute It is weary, cause internal glucose that cannot be utilized, protein and fat consumption increase, so as to cause out of strength, weight loss；In order to mend The sugar of loss is repaid, body activities are maintained, needs feed more；Which forms typical " three-many-one-little " symptoms.Patient of diabetes The severity of more drinks of person, diuresis symptom and the state of an illness is proportional.Moreover, it is noted that patient eats more, blood glucose is just Higher, mistake sugar is also more in urine, and hunger is also more severe, has eventually led to vicious circle.
Cancer, that is, malignant tumour is a kind of disease for seriously jeopardizing human life.It is treated using the means of traditional Chinese medicine swollen Tumor disease is a urgently channel leaved for development, this is because traditional Chinese medicine has the features such as medicinal peace, applied widely, therefore As the effect for having its original in terms of oncotherapy.
Summary of the invention
The prior art rarely have about report can simultaneously effectively prevent and/or treating cancer, hemorrhoid and three high drugs, this hair It is bright to be designed to provide a kind of composition not only there is single effect, while also having good effect in other effects.Tool Body, applicants have found that preventing and/or controlling the compatible use of Honeysuckle flower, Chinese rhubarb extract, Coelomactra antiquata and American Ginseng Treating on cancer, hemorrhoid and three height has good effect.
Specific scheme is as follows:
A kind of complex composition containing Coelomactra antiquata, according to parts by weight, including following components: 1-5 parts of Honeysuckle flower, rheum officinale extract 0.1-1 parts of object, 1-3 parts of Coelomactra antiquata, 0.1-2 parts of American Ginseng.
Including following components preferably, according to parts by weight: 3 parts of Honeysuckle flower, 0.5 part of Chinese rhubarb extract, 1 part of Coelomactra antiquata, 0.5 part of American Ginseng.
Research is found added with the effect for being conducive to improve prevention and treatment hemorrhoid after lilac, specifically, further including lilac 1-6 Part.
In a specific embodiment of the invention, the Chinese rhubarb extract is selected from rheum emodin.
In a specific embodiment of the invention, the composition further includes one or more acceptable in corresponding field Auxiliary material is used to prepare into drug, food, drink or health care product.
In an of the invention specific embodiment, the dosage form of the composition includes liquid agent, solid formulation, semisolid agent, Including but not limited to following dosage form, as oral solution, granule, pill, powder, paste, sublimed preparation, suspension, pulvis, solution, Injection, suppository, creme, spray etc..
The present invention also provides a kind of preparation methods of complex composition containing Coelomactra antiquata, including the following contents: by each component It is prepared into powder, is mixed according to the ratio, or is aided in other pharmacy or food acceptable auxiliary material or complementary ingredient again according to existing There is common process disclosed in technology to carry out the product that corresponding dosage form is prepared；Wherein, powder includes being prepared into Ultramicro-powder.
After either each group lease making water is mentioned, obtained by the operation preparations such as being concentrated, drying, or be equipped with other auxiliary material systems again For at corresponding dosage form.Particularly, wherein Chinese rhubarb extract can add when mixing in the later period, and other components are not limited to select Select the product that water mentions.
The present invention also provides the complex composition containing Coelomactra antiquata is applied to preparation prevention and/or treating cancer, hemorrhoid Sore or three high drugs, food, drink or field of health care products.
In a specific embodiment of the invention, the dosage form of drug of the present invention includes tablet, sugar coated tablet, Film coated tablets Agent, enteric coated tablet, capsule, oral solution, mouth containing agent, granule, electuary, pill, powder, paste, sublimed preparation, suspension, powder Agent, solution, injection, suppository, ointment, emplastrum, creme, spray, drops or patch.
The dosage form of the health care product include pulvis, tablet, capsule, liquid agent, suspension, emulsion, oral solution, jelly or Electuary.
Food, drink can be prepared into existing disclosed all dosage forms.
Adaptable acceptable auxiliary material in the art can be added in preparing each dosage form.
Composition of the invention, oral preparation can contain common excipient, such as adhesive, filler, diluent, Tablet agent, lubricant, disintegrating agent, colorant, flavoring agent and wetting agent when necessary can be coated tablet.
Applicable filler includes cellulose, mannitol, lactose and other similar fillers.Suitable disintegrating agent packet Include starch, polyvinylpyrrolidone and starch derivatives, such as sodium starch glycollate.Suitable lubricant includes, such as firmly Fatty acid magnesium.Suitable pharmaceutically acceptable wetting agent includes lauryl sodium sulfate.It can be filled, tabletting etc. is common by mixing Method prepare solid oral composition.Carrying out mixing repeatedly can make active material be distributed in that for entirely using a large amount of fillers In a little compositions.
The form of oral liquid for example can be aqueous or oily suspensions, solution, emulsion, syrup or elixir, Or it can be a kind of dry products that can be compounded with water or other suitable carriers before use.This liquid preparation can contain Conventional additive, such as suspending agent, such as sorbierite, syrup, methylcellulose, gelatin, hydroxyethyl cellulose, carboxymethyl are fine Dimension element, aluminium stearate gel or hydrogenated edible fats, emulsifier, such as lecithin, anhydro sorbitol monooleate or Arab Glue；Non-aqueous carrier (they may include edible oil), for example, apricot kernel oil, fractionated coconut oil, such as glycerol ester oily ester, Propylene glycol or ethyl alcohol；Preservative, such as para hydroxybenzene methyl esters or propylparaben or sorbic acid, and if desired, Contain conventional flavouring agent or colorant.
For injection, the fluid unit dosage form of preparation contains active material and sterile carrier of the invention.According to carrier And concentration, this compound can be suspended or be dissolved.The preparation of solution is usually by the way that active material is dissolved in a kind of load In body, disinfection is filtered before being loaded into a kind of suitable bottle or ampoule, is then sealed.For example a kind of local anaesthesia of auxiliary material Agent, preservative and buffer are also soluble in this carrier.It, can be after being packed into bottle by this in order to improve its stability Kind composition frost, and under vacuum remove water.
Suitable pharmaceutically acceptable load is optionally added pharmaceutical composition of the invention when being prepared into medicament Body, the pharmaceutically acceptable carrier are selected from: mannitol, sorbierite, sodium pyrosulfite, sodium hydrogensulfite, sodium thiosulfate, salt Sour cysteine, thioacetic acid, methionine, injection Vitamin B_6 DTA disodium, Ethylenediaminetetraacetic Acid Calcium Salt, carbonate, the acetic acid of monovalence alkali metal Salt, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acid, sodium chloride, potassium chloride, sodium lactate, xylitol, wheat Bud sugar, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its Derivative, alginates, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surface-active Agent, polyethylene glycol, cyclodextrin, beta-cyclodextrin, phospholipid material, kaolin, talcum powder, calcium stearate, magnesium stearate etc..
Above-mentioned each auxiliary material such as carrier, excipient are not limited to the use in specific dosage form.
It is tangible that the existing disclosed institute such as teabag drink, tea bag, tea beverage can be made in application in health care product, drink or food Formula.
Compared with prior art, beneficial effects of the present invention:
Honeysuckle flower of the present invention can be clearing heat and detoxicating, promotes the production of body fluid and only drinks, and reduces the activity of liver catalase and choline enzyme Power, it is possible to which anti-curing cancers, rheum emodin energy expelling wind and removing dampness, can treat outside rheumatism jaundice at broken stasis of blood promoting menstruation, moreover it is possible to stomach is cleared up, Admittedly hemorrhoid can be prevented.Coelomactra antiquata energy enriching yin nutrient solution, heat-clearing cool liver, tonifying yin strengthening the essence, profit internal organs stop polydipsia.It is American Ginseng benefit lung yin, clear The fire of deficiency type promotes the production of body fluid to quench thirst.For the present invention using Coelomactra antiquata as monarch drug in a prescription, Honeysuckle flower, rheum emodin, American Ginseng are ministerial drug, and American Ginseng is assistant, makes Medicine provides a kind of composition of monarch compatibility, can promote the production of body fluid to quench thirst, toxin-expelling and face nourishing, relieving restlessness is refreshed oneself, health takes care of health, clearly The clear kidney gut purge stomach of liver, the anti-hemorrhoid that can give protection against cancer again anti-three are high, commonly use without side-effects.
Specific embodiment
Technical solution of the present invention will be clearly and completely described below, it is clear that described embodiment is only A part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art Every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term " and or " used herein includes one or more phases Any and all combinations of the listed item of pass.
In the application, if can be commercially available by commercially available without raw material selected by special statement, auxiliary material.
The present invention provides formula as below:
Honeysuckle flower be selected from 1,1.5,2,2.5,3,3.2,3.5,4.5,5 part etc., Chinese rhubarb extract be selected from 0.1,0.2,0.3, 0.4,0.5,0.6,0.7,0.8,0.9,15 part etc., Coelomactra antiquata be selected from 1,1.5,2,2.4,2.5,3 part etc., American Ginseng 0.1,0.2, 0.3, the ratio of any combination such as 0.4,0.5,0.6,1,1.5,2 part, then be equipped with lilac 1,1.5,2,2.5,3,3.5, 4, the mixture of 4.5,5,5.5,6 parts etc. of composition.
Following no specified otherwise with 3 parts of Honeysuckle flower, 0.5 part of Chinese rhubarb extract, 1 part of Coelomactra antiquata, 0.5 part of American Ginseng ratio For the composition of example.
Utilize the clinical statistics data of the various hemorrhoid patients of drug therapy of the present invention:
By the clinical use of 100 patients, wherein male patient 60, female patient 40, the age is minimum in medication object 14 years old, maximum 75 years old.Wherein internal piles patient 35 all cure；External piles patient 40, healing 37, effective 2, nothing Effect 1；Mixed hemorrhoid patient 10, cure 9, effective 1；Anal fistula patient 15, cure 13, invalid 2.
The application method of drug of the present invention: the present composition is prepared into externally applied drug, and is applied to affected part, medication cycle seven It, daily medication is primary.
Hemorrhoid diagnostic criteria:
Internal piles: showing as hematochezia, rectal prolapse, and itch flows mucus, falling inflation, eczema of anus and constipation.
External piles: showing as falling inflation, and pain has foreign body sensation and has fistulae.
Mixed hemorrhoid: inside and outside hemorrhoid symptom complex is shown as.
Criterion of therapeutical effect:
Recovery from illness standard: internal piles, external piles, the symptom of mixed hemorrhoid completely disappear.
Effective standard:
Internal piles: the symptom of hematochezia, itch, stream mucus, falling inflation, eczema of anus and its constipation disappears, and rectal prolapse mitigates；
External piles: falling inflation, pain and the symptom disappearance for having foreign body sensation, fistulae mitigate；
Mixed hemorrhoid: for internal piles, the general performance of effective standard of external piles.
Null criterion: internal piles, external piles, the symptom of mixed hemorrhoid do not change.
Typical case:
1, patient: Mr. Wang, 14 years old, male suffered from internal piles 1 year, once did hemorrhoids operation, if excessive internal heat amount of bleeding increases, It often takes medicine, with all kinds of acne creams, does not feel any better.It uses and just works on the day of medication after the present composition, fully recover after 5 days, 2 It pays a return visit, has not relapsed so far after year.
2, patient: Zhang, 70 years old, female suffered from external piles 7 years, and hemorrhoid are serious, and hematochezia is serious, walk not aspect.It is a variety of Medication treatment is not cured, recurrent exerbation, daily to smear using paste prepared by the present invention, after medication 3 days i.e. effectively, continues to make With being discontinued after 10 days, hematochezia symptom fades away, and fully recovers after a week.It is paid a return visit after 3 years, no recurrence.
3, patient: Yao so-and-so, 45 years old, male, suffer from mixed hemorrhoid 4 years, hemorrhoid are serious, and hematochezia is serious, and frequent itch is hard to bear, and companion Have that anus is moist, it is the same that perceptual image goes out viscous sweat, walk not in terms of, it is invalid often to smear medicine.Smearing one time daily, medication 5 days, After drug withdrawal, hematochezia, pruritis fade away, and fully recover after 15 days.Follow-up after 2 years, does not recur.
At random to wherein 30 patients, using 3 parts of Honeysuckle flower, 0.5 part of Chinese rhubarb extract, 1 part of Coelomactra antiquata, American Ginseng 0.5 Part, the composition of 3 parts of lilac of ratio.
It is found in the use process to patient, in the case where same dosage, after the patient medication containing lilac Universal onset time can shorten 0.5 day or so, and medication cycle can shorten 1-3 days, in same or similar (sick time, hemorrhoid portion Position etc.) under the state of an illness compared to not using patient's cure time of lilac shorter, about can shorten 3-5 days.
Randomly choose 50 patients again, wherein it is inside and outside, mixed hemorrhoids Proportion of patients is roughly equal, be set as control group, i.e., Without Coelomactra antiquata component, other components dosage is identical.
Applicant further has found that the compatible use of Coelomactra antiquata and rheum emodin is conducive to improve the effect for the treatment of hemorrhoid, Under same or approximate condition, patient group (being randomly assigned, the inside and outside, mixed hemorrhoids patient) discovery without Coelomactra antiquata contains west The effective percentage and cure rate and recurrence rate for applying the patient group of tongue are significantly worse than the patient group containing Coelomactra antiquata, wherein it is efficient and Cure rate wants poor 7%, 6%, and high recurrence rate 2%, patient group effective percentage and cure rate and recurrence rate containing Coelomactra antiquata are respectively 99%, 97%, 0.5%.
According to the factor for suffering from the various aspects such as feelings, medication subjective feeling of patient, can be treated using different pharmaceutical formula Hemorrhoid, shorter treatment time, medication be more comfortable, rapid-onset and other effects to obtaining, it is above do not enumerate completely it is all Medication combination and using these combination patient's embodiment.
Utilize the clinical statistics data of the various the three high patients of drug therapy of the present invention:
Chinese materia medica preparation instructions of taking of the invention is: it is oral, 2 times a day, and before meals with warm water delivery service, 5-10 grams every time, A month as a course for the treatment of.
To show Chinese materia medica preparation of the invention to the therapeutic effect of three high diseases, the present inventor sees 150 case clinics It examines, wherein 80 people of male, 70 people of women, the age 35-80 years old, course of disease 3-7, wherein hypertension 50, hyperlipidemia 50, glycosuria Disease 50.By long-term drinking drink of the invention, the state of an illness is effectively relieved, and for cure rate up to 89%, effective percentage is 99%.
Typical clinical case
1, Mr. Wang, male 65 years old, suffers from hypertension 5 years, after drinking 4 months, blood pressure stabilization, physical condition is normal so far.
2, certain is thanked, female 50 years old, suffers from hyperlipidemia 3 years, and after drinking 3 months, blood lipid is stablized, and physical condition is normal so far.
3, Zhang, male 36 years old, suffer from hyperglycemia 2 years, after drinking 7 months, glucostasis, physical condition is normal so far.
It is found surprisingly that, wherein checking discovery cancer in hospital after also suffering from patient's long-period drinking of said product of cancer simultaneously Stable disease has obtained preferable control.
Further, to 40 random patients, setting is free of the control group 1 of Coelomactra antiquata, and other components dosage is constant；With And the control group 2 containing lilac, other components dosage are constant.
In same or approximate situation, wherein drinking the patient of the drink containing Coelomactra antiquata, cancer improvement better off is special Other is to drink the improvement situation of the patient containing Coelomactra antiquata and lilac simultaneously to be substantially better than other patients.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of complex composition containing Coelomactra antiquata, which is characterized in that according to parts by weight, including following components: Honeysuckle flower 1-5 Part, 0.1-1 parts of Chinese rhubarb extract, 1-3 parts of Coelomactra antiquata, 0.1-2 parts of American Ginseng.
2. complex composition containing Coelomactra antiquata according to claim 1, which is characterized in that according to parts by weight, including with the following group Point: 3 parts of Honeysuckle flower, 0.5 part of Chinese rhubarb extract, 1 part of Coelomactra antiquata, 0.5 part of American Ginseng.
3. complex composition containing Coelomactra antiquata according to claim 1, it is characterised in that: further include 1-6 parts of lilac.
4. complex composition containing Coelomactra antiquata according to claim 1, it is characterised in that: the Chinese rhubarb extract is selected from rheum officinale Element.
5. complex composition containing Coelomactra antiquata according to claim 1, it is characterised in that: the composition further includes a kind of or more The food or pharmaceutically acceptable auxiliary material of kind.
6. complex composition containing Coelomactra antiquata according to claim 1, it is characterised in that: the dosage form of the composition includes Liquid agent, solid formulation, semisolid agent.
7. the preparation method of the complex composition containing Coelomactra antiquata as described in claim 1-6 is any, which is characterized in that including following interior Hold: each component is mixed according to the ratio to get.
8. complex composition containing Coelomactra antiquata is in preparation prevention and/or treating cancer, hemorrhoid or three as described in claim 1-6 is any Application in high drug, food, drink or health care product.
9. applying according to claim 8, it is characterised in that: the dosage form of the drug include tablet, capsule, oral solution, Mouth containing agent, granule, pill, powder, paste, sublimed preparation, suspension, pulvis, solution, injection, suppository, creme, spray, Drops or patch.
10. applying according to claim 8, it is characterised in that: the dosage form of the health care product include pulvis, tablet, capsule, Liquid agent, suspension, emulsion, oral solution, jelly or electuary.
CN201910580276.4A 2019-06-28 2019-06-28 Complex composition containing Coelomactra antiquata and its preparation method and application Pending CN110169993A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102727528A (en) * 2012-06-21 2012-10-17 王德亮 Hemorrhoid treatment medicine and its preparation method
CN106619854A (en) * 2016-11-28 2017-05-10 马志恒 External traditional Chinese medicine composition for treating haemorrhoids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102727528A (en) * 2012-06-21 2012-10-17 王德亮 Hemorrhoid treatment medicine and its preparation method
CN106619854A (en) * 2016-11-28 2017-05-10 马志恒 External traditional Chinese medicine composition for treating haemorrhoids

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