CN110160854A - It is a kind of to keep the device of bead suspension uniformity, method and application thereof - Google Patents
It is a kind of to keep the device of bead suspension uniformity, method and application thereof Download PDFInfo
- Publication number
- CN110160854A CN110160854A CN201910435466.7A CN201910435466A CN110160854A CN 110160854 A CN110160854 A CN 110160854A CN 201910435466 A CN201910435466 A CN 201910435466A CN 110160854 A CN110160854 A CN 110160854A
- Authority
- CN
- China
- Prior art keywords
- hole location
- bead suspension
- reagent
- bead
- rotation structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F29/00—Mixers with rotating receptacles
- B01F29/10—Mixers with rotating receptacles with receptacles rotated about two different axes, e.g. receptacles having planetary motion
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/10—Mixers with shaking, oscillating, or vibrating mechanisms with a mixing receptacle rotating alternately in opposite directions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
- G01N2001/386—Other diluting or mixing processes
Abstract
First aspect present invention discloses a kind of device for keeping bead suspension uniformity comprising rotation reagent platform (1)；There are bead suspension container (3) thereon, the outer wall of the suspension magnetic bead container (3) is provided with the first cause rotation structure；Non-rotary cylinder (2), it is provided in its peripheral surface and causes the second of rotation structure cooperation to cause rotation structure with described first, so that the suspension magnetic bead container (3) is driven the rotation in hole location while revolution when rotating reagent platform (1) rotation.Second aspect of the present invention discloses the method for keeping bead suspension uniformity using described device.Third aspect present invention discloses described device for keeping the purposes of bead suspension uniformity in elongated vessel of the draw ratio greater than 2.The present apparatus maintains the uniformity of entire reaction system mixing, is especially suitable for the mixed process of micro liquid in elongated tubular.
Description
Technical field
The present invention relates to Life Science Instruments and medical test apparatus field, and in particular to a kind of holding bead suspension is equal
The device of even property, method and application thereof.
Background technique
In the analysis method and clinical medicine diagnostic field for life science, partial size is in sub-micron between tens microns
Magnetic particle (or magnetic bead) be used as a key analytical reagent component, be typically used to enrichment and separation complexity tested sample
Measured object in (such as blood, urine or other body fluid).Especially in the clinical immunization based on all kinds of chemiluminescence principles point
It analyses in instrument system, surface-functionalized magnetic particle and other reagents are (as the signal antibody after marking, biotinylated capture are anti-
Antigen etc. after body and functionalization) together as a reagent component individually packed in kit.
In the immunoassay of a kind of referred to as sandwich (sandwich) method, when these reagents are by the amount (volume × concentration) of setting
Mixed with sequence with tested sample (such as blood), and in certain temperature after reacting for a period of time, the measured object in sample just by
The antibody capture on magnetic particle surface " is caught with the signal antibody after label in magnetic bead surfaces formation on magnetic particle, and further
Obtain antibody-target measured object-signal antibody " the so-called sandwich product that successively combines, i.e. immunocomplex.This process is claimed
To be incubated for process.After being incubated for completion, using the paramagnetic properties of magnetic bead, under the action of externally-applied magnetic field, with immunocomplex
The measured object that form is enriched in magnetic bead surfaces can be separated with other in sample at split-phase by Magneto separate and cleaning process,
To avoid the interference of a large amount of existing red blood cells, white blood cell, blood platelet, bilirubin in other materials such as blood in sample,
Greatly improve detection sensitivity.
Due to the effect of gravity, the micron order magnetic bead being suspended in kit can gradually be sunk to after standing in kit
The bottom of reagent container causes pipettor such as liquid-transfering gun, liquid-transfering needle or sampling probe that cannot get or cannot accurately get and sets
Quantitative magnetic bead, so as to cause the analysis result of mistake.In past instrument system, solve the problems, such as that this scheme has two
It is a: first is that first protruding into the container bottom for holding magnetic bead by magnetic bead again with mechanical stirring paddle every time before pipettor draws magnetic bead
Suspension gets up to form mixed uniformly bead suspension and draw immediately；Second is that being in the entire mistake of test job state in instrument
Cheng Zhong makes the container for holding magnetic bead continuous or with gap in rotating or shaking state to guarantee bead suspension in instrument work
During state always uniformly.Elecsys and cobas series of the first method in Roche Diagnistics (Roche Diagnostics)
It is used on Electrogenerated chemiluminescent immunoassay instrument.Other commercial system uses second method, general to utilize a reciprocal fortune
It dynamic rack gear and drives magnetic bead container to make reciprocating rotary in the gear of magnetic bead container outer wall, or can also allow the appearance for holding magnetic bead
Device is in continuous or gap concussion state to avoid magnetic bead from settling or the particle settled is allowed to float again.
Above two method has the shortcomings that certain, and the effect of the Strong shear of mechanical stirring paddle is easily destroyed the function of magnetic bead surfaces
Can property substance, and after the design and movement of instrument complicate, increase fallibility.The rack drives magnetic bead of reciprocating motion
Container does reciprocating rotary can be in the uneven distribution for being formed radially magnetic bead particles of elongated tube-type receptacle, while rack and pinion is past
The fixed regular noise to rub again is also unpleasant.Concussion method is effective to the suspension mixing of superficial layer, and to elongated tubular
The mixed effect of depths sedimented particle in type container is bad.
Two schemes are required at least one motor and electric machine control system, therefore in the design of miniature instrument, above-mentioned
The variation of structure brought by the attachment device used in two methods and equipment instrument is all unfavorable.
Therefore, under the premise of not increasing the volume and mechanism complexity of detecting instrument as far as possible, how to keep being placed in life
The uniformity of bead suspension in analyte detection or medical diagnostic equipment is always field of biological detection or automatic lmunoassays analyzer
A problem to be solved in device design.
Summary of the invention
In order to solve the above problem, the present invention is proposed.
The present invention drives the rotation of magnetic bead container using the original necessary rotation of the kit being loaded on instrument, thus
Realize the uniformity of bead suspension.
First aspect present invention provides a kind of device for keeping bead suspension uniformity comprising,
Reagent platform 1 is rotated, there is at least one reagent wells hyte in circumferential array, the reagent wells hyte packet thereon
The first hole location is included, places bead suspension container 3 in first hole location, the outer wall of the bead suspension container 3 is provided with
First causes rotation structure；
Non-rotary cylinder 2, peripheral surface are contacted with the outer wall of all bead suspension containers 3, circumferential table
It is provided on face and causes the second of rotation structure cooperation to cause rotation structure with described first, so that being rotated in the rotation reagent platform 1
When, the bead suspension container 3 will be driven the rotation in first hole location while revolution.
Certain cylinder 2 can be less than the cylinder of round diameter, i.e. disk for height.
Preferably, described device further includes shell 6, and the reagent wells hyte further includes the second hole location and third hole location, institute
It states and places the second Reagent Tube 4 and third Reagent Tube 5 in the second hole location and third hole location respectively or inherently constitute the second Reagent Tube 4
With third Reagent Tube 5.
Preferably, described first rotation structure and second is caused to cause rotation structure for gear；Or described first cause rotation structure and the
Different rotation structure is friction material layer independently of one another, or the surface that is coarse or having decorative pattern being arranged on wall surface；Or institute
N number of radially protruding part that the first cause rotation structure is the cylinder (2) is stated, wherein N is the positive integer more than or equal to 1.
Preferably, each reagent wells hyte includes first hole location and at least one second hole location and at least one
Third hole location.
Preferably, the height of the bead suspension container 3 is at least 2 times of internal diameter.
Preferably, the shell 6 is non-covered container, and the non-rotary cylinder 2 is fixed on the non-covered container bottom.
Preferably, the shell 6 is the cup-like containers for having detachable lid 7, and the non-rotary cylinder 2 is fixed on described
The inside of lid 7.
Preferably, the lid 7 is transparent or partially transparent.
Second aspect of the present invention provides a kind of method for keeping bead suspension uniformity, using described in first aspect
Device comprising the steps of:
A, bead suspension is put into the bead suspension container 3 being placed in the first hole location；
B, open described device, the bead suspension container 3 it is described rotation reagent platform 1 drive under revolve and according to
It is driven the rotation in first hole location by the first cause rotation structure and the second cause rotation structure, so that the bead suspension
Spin occurs so that magnetic bead therein does not settle.
Preferably, in step A, two reagents are respectively put into the second Reagent Tube being placed in the second hole location and third hole location
4 and third Reagent Tube 5 or the second Reagent Tube 4 and third Reagent Tube 5 that are made of the second hole location and third hole location itself in.
Preferably, wherein the diameter of the magnetic bead is not more than 10 microns.
Preferably, described device further includes the binding bracket 8 for fixing the reagent wells hyte.
Preferably, the bead suspension container 3 can be hanged in the magnetic bead by clockwise and be counterclockwise alternately rotated
It forms surge in supernatant liquid container 3 magnetic bead for having fallen to container bottom is suspended and mixed again.
Third aspect present invention provides device described in first aspect for keeping magnetic in elongated vessel of the draw ratio greater than 2
The purposes of pearl suspension uniformity.
Beneficial effects of the present invention:
(1) rotation function of rotation reagent platform of the invention is to meet to move up in fixed position and take the requirement of reagent
And must be provided in Instrument Design, it is not to be added for magnetic bead mixing.Therefore, in addition to adding cylinder in the apparatus
Component, and the outer wall of magnetic bead container is modified slightly to meet outside its gear drive or frictional drive with cylindrical member, this
Invention is achieved that holding magnetic bead uniformly hangs during instrument work without increasing additional complex mechanism and automatic control unit
Floating purpose.Compared with past scheme, reduce at least one motor and electric machine control system.
(2) rotation for the bead suspension container that the device of the invention is driven using the rotation of rotation reagent platform is to drive
The spin of its interior liquid maintains the uniformity of entire reaction system mixing, avoids the sedimentation of magnetic bead, and do not destroy magnetic bead table
The functional materials in face, the shortcomings that avoiding concussion and be stirred.
(3) the device of the invention is especially suitable for the mixed process of micro bead suspension in elongated tubular, can be used for biological doctor
Learn detection field.
(4) the device of the invention is suitble to batch incubation reaction and detection operation, can be used in automated detection system, and because
To avoid rotating device relevant to more agitating paddles and driving device, can detection device be minimized.
Detailed description of the invention
Fig. 1 is a kind of top view for the device specific structure for keeping bead suspension uniformity of embodiment 1.
Fig. 2 is a kind of perspective view for the device specific structure for keeping bead suspension uniformity of embodiment 2.
Fig. 3 is a kind of top view for the device specific structure for keeping bead suspension uniformity of embodiment 3.
Reference signs list:
1, reagent platform is rotated；2, cylinder；3, bead suspension pipe；4, signal antibody Reagent Tube；5, antibody reagent is captured
Pipe；6, shell；7, lid；8, bracket is bundled.
Specific embodiment
The contents of the present invention are further illustrated below by specific embodiment.
Embodiment 1
A kind of device keeping bead suspension uniformity, as shown in Figure 1, include,
Non-covered container shell 6；
Reagent platform 1 is rotated, there is four reagent wells hytes in circumferential array, each reagent wells hyte packet thereon
First hole location, second hole location, a third hole location are included, bead suspension pipe 3 is placed in first hole location, it is described
Signal antibody Reagent Tube 4 and capture antibody reagent pipe 5, the bead suspension pipe 3 are placed in second hole location, third hole location respectively
Outer wall be provided with friction material layer, inner wall be it is coarse, the length of the bead suspension pipe is 2 times of internal diameter；For solid
The binding bracket 8 of the fixed reagent wells hyte；
Non-rotary cylinder 2, peripheral surface are contacted with the outer wall of all magnetic bead containers 3, are set in peripheral surface
It is equipped with and causes the second of rotation structure cooperation to cause rotation structure with described first, so that in the rotation reagent platform 1 rotation, it is described
Bead suspension container 3 will be driven the rotation in the inside hole location while revolution.
By adjusting rotation 1 size of reagent platform, reagent wells hyte size, non-rotary cylinder 2 diameter and magnetic bead pipe 3
Size, the magnetic bead even suspension in one or more sets reagents may be implemented using the device.
Embodiment 2
Another keeps the device of bead suspension uniformity, as shown in Fig. 2, being with Fig. 1 difference, the shell 6
To there is the cup-like containers of dismountable all-transparent lid 7, the non-rotary cylinder 2 is fixed on the inside of the lid 7.Lid
7, which are designed as transparent facilitating, observes device internal-response situation.
Embodiment 3
Fig. 3 shows the third device for keeping bead suspension uniformity, essentially consists in Fig. 1 difference, described second
Hole location and third hole location are sequentially arranged on the same radius of rotation reagent platform 1.
Embodiment 4
A method of bead suspension uniformity is kept, device described in embodiment 1 is utilized, this method includes following
Step:
A, bead suspension is put into the bead suspension container 3 being placed in the first hole location, by signal antibody reagent and
Capture antibody reagent is respectively put into the signal antibody Reagent Tube 4 being placed in the second hole location and third hole location and capture antibody reagent pipe
In 5；
B, open described device, the bead suspension container 3 it is described rotation reagent platform 1 drive under revolve and according to
It is driven the rotation in first hole location by the first actuating structure and the second actuating structure, so that the bead suspension
Spin occurs so that magnetic bead therein does not settle.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be subject to the protection scope in claims.
Claims (10)
1. a kind of device for keeping bead suspension uniformity, which is characterized in that including,
It rotates reagent platform (1), there is at least one reagent wells hyte in circumferential array thereon, the reagent wells hyte includes
First hole location, first hole location is interior to place bead suspension container (3), the outer wall setting of the bead suspension container (3)
There is the first cause rotation structure；
Non-rotary cylinder (2), peripheral surface are contacted with the outer wall of all bead suspension containers (3), circumferential table
It is provided on face and causes the second of rotation structure cooperation to cause rotation structure with described first, so that being revolved in the rotation reagent platform (1)
When turning, the bead suspension container (3) will be driven the rotation in first hole location while revolution.
2. the apparatus according to claim 1, which is characterized in that described device further includes shell (6), the reagent wells hyte
Further include the second hole location and third hole location, places the second Reagent Tube (4) and third in second hole location and third hole location respectively
Reagent Tube (5) inherently constitutes the second Reagent Tube (4) and third Reagent Tube (5).
3. the apparatus according to claim 1, which is characterized in that described first causes rotation structure and second to cause rotation structure for tooth
Wheel；Or the first cause rotation structure and the second cause rotation structure are friction material layer independently of one another, or are arranged on wall surface
Surface that is coarse or having decorative pattern or the first cause rotation structure are N number of radially protruding part of the cylinder (2), and wherein N is
Positive integer more than or equal to 1.
4. the apparatus according to claim 1, which is characterized in that each reagent wells hyte includes at least one second hole
Position and at least one third hole location.
5. the apparatus according to claim 1, which is characterized in that the height of the bead suspension container (3) is at least interior
2 times of diameter.
6. the apparatus according to claim 1, which is characterized in that the shell (6) is non-covered container, the non-rotary circle
Column (2) is fixed on the non-covered container bottom, it is preferable that the lid (7) is transparent or partially transparent.
7. the apparatus according to claim 1, which is characterized in that the shell (6) is to have the cup-shaped of detachable lid (7) to hold
Device, the non-rotary cylinder (2) are fixed on the inside of the lid (7).
8. a kind of method for keeping bead suspension uniformity, which is characterized in that utilize device described in claim 1, include
Following steps:
A, bead suspension is put into the bead suspension container (3) being placed in the first hole location；
B, open described device, the bead suspension container (3) it is described rotation reagent platform (1) drive under revolve and according to
It is driven the rotation in first hole location by the first cause rotation structure and the second cause rotation structure, so that the bead suspension
Spin occurs so that magnetic bead therein does not settle；
Preferably, in step A, other two reagent is respectively put into the second Reagent Tube being placed in the second hole location and third hole location
(4) and third Reagent Tube (5) or the second Reagent Tube (4) and third Reagent Tube that are made of the second hole location and third hole location itself
(5) in.
9. according to the method described in claim 8, wherein the diameter of the magnetic bead is not more than 10 microns.
10. device described in claim 1 is for keeping the use of bead suspension uniformity in elongated vessel of the draw ratio greater than 2
On the way.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910435466.7A CN110160854B (en) | 2019-05-23 | 2019-05-23 | Device and method for keeping uniformity of magnetic bead suspension and application of device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910435466.7A CN110160854B (en) | 2019-05-23 | 2019-05-23 | Device and method for keeping uniformity of magnetic bead suspension and application of device |
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| CN110160854A true CN110160854A (en) | 2019-08-23 |
| CN110160854B CN110160854B (en) | 2022-07-15 |
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| CN201910435466.7A Active CN110160854B (en) | 2019-05-23 | 2019-05-23 | Device and method for keeping uniformity of magnetic bead suspension and application of device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115364732A (en) * | 2022-08-01 | 2022-11-22 | 沈阳富创精密设备股份有限公司 | Uniform treatment method for micro-nano material suspension |
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| CN103235148A (en) * | 2013-04-25 | 2013-08-07 | 深圳市国赛生物技术有限公司 | Reagent disk |
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