CN110150673A - It is a kind of to remarkably promote the nutrient composition and preparation that calcium source efficient absorption utilizes - Google Patents

It is a kind of to remarkably promote the nutrient composition and preparation that calcium source efficient absorption utilizes Download PDF

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Publication number
CN110150673A
CN110150673A CN201910385236.4A CN201910385236A CN110150673A CN 110150673 A CN110150673 A CN 110150673A CN 201910385236 A CN201910385236 A CN 201910385236A CN 110150673 A CN110150673 A CN 110150673A
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calcium
parts
vitamins
electronics
composition
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陈松
陈晨
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KUNMING LONGSHINE BIOTECHNOLOGY Co Ltd
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KUNMING LONGSHINE BIOTECHNOLOGY Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A23L33/165—Complexes or chelates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention relates to a kind of nutrient compositions that promotion calcium source efficient absorption utilizes, and are made of multi-vitamins electronics chelating calcium, zinc citrate.Wherein: multi-vitamins electronics chelates the predetermined substance that calcium is certain aspects of the present invention preparation, is mixed to prepare the present composition with special ratios and zinc citrate.Compared to inorganic acid calcium, calcium of organic acid, amino acid calcium and combinations thereof and preparation, the present composition uses multi-vitamins electronics chelating calcium as calcium source for the first time, has higher bio-dissipative and availability.While mutually being cooperateed between fully considering composition specific composition material nutrition element, single replenish the calcium caused savings and GI irritation are significantly reduced, realizes the technical effect that calcium source efficient absorption utilizes, various nutrients collaboration supplements.

Description

It is a kind of to remarkably promote the nutrient composition and preparation that calcium source efficient absorption utilizes
Technical field
The nutrient composition and preparation that calcium source efficient absorption utilizes are remarkably promoted the present invention relates to a kind of, belongs to biological doctor The big health field of medicine.
Background technique
Calcium is macroelement indispensable in human life, and it is even dead that calcium deficiency will lead to whole body Multiple organs disorders.By In Chinese residents with cereal for main dietary structure, calcium source content and the higher food of quality for example milk, dried small shrimp, sardine, Sesame, hyacinth bean, kelp, nut etc. seldom enter dining table, lead to the universal calcium deficiency of Chinese.Chinese Soclety of Nutrition's statistics, it is adult every Its calcium deficiency amount is about 400mg, the daily calcium deficiency amount of Children and teenager is 600-800mg, pregnant woman wet nurse and the daily calcium deficiency of the elderly Amount is about 600mg.
Calcium creates benefit dazzling in the market to the objective fact of human health importance and the universal calcium deficiency of Chinese Calcium product.Make a general survey of domestic and international calcium nutrient research and development application situation: its calcium source is predominantly inorganic/organic calcium salt；It, which is studied, applies shape Formula is mainly single calcium source supplement, calcium source and vitamin D3Compounding, calcium source and multivitamin minerals simple combination.From lack Calcium, mechanism of replenishing the calcium and balanced nutritious angle, the prior art at least have following bottlenecks: 1. calcium uptake utilization rate is relatively low, long Phase or excessive supplement easily cause digestive system, urinary system deposition, lead to constipation or stone in urinary system；2. the nothing in conjunction with calcium source There is stimulation in various degree to gastrointestinal tract in machine/organic acid anions, easily cause the gastrointestinal discomforts symptoms such as pernicious, vomiting, excessive Or there are acid ions to put aside poisoning risk for long-term consumption；3. considering while replenishing the calcium the collaboration of other nutrients, antagonism It is less, it is eaten for a long time unbalanced between may aggravating needed by human body nutrient.
The present invention calcium nutrient research and development application there are aiming at the problem that and bottleneck, initiative use technical solution of the present invention system Standby multi-vitamins electronics chelating calcium is combined with zinc citrate, while realizing that calcium source is quick, efficient absorption utilizes, sufficiently Consider collaboration, antagonism between each specific composition substance of composition and nutrient, it is ensured that each nutrient is balanced while replenishing the calcium.
Summary of the invention
The first object of the present invention is to provide a kind of nutrient composition for remarkably promoting calcium source efficient absorption and utilizing, Two are designed to provide the preparation method of the composition；Third is designed to provide the composition application.Battalion provided by the invention Feeding promotor composition not only remarkably promotes calcium source and is absorbed and utilized, and has and absorb fastly, without deposition and GI irritation, nutrient equilibrium The features such as.
The first object of the present invention is achieved through the following technical solutions.
Firstly, the present invention provides a kind of nutrient composition for remarkably promoting calcium source efficient absorption and utilizing, the composition It is made of multi-vitamins electronics chelating calcium, zinc citrate.It is characterized by:
1. multi-vitamins electronics chelates calcium system by homogeneous homogenization process, using sodium carboxymethylcellulose slurrying, by lemon The abundant homogeneous homogenate of lemon acid calcium, D-VB5 calcium, multivitamin composite powder, lactose, low temperature drying are made；Wherein, calcareous amount hundred Dividing content is 14.14%~18.65%, preferably 15.89%~17.40%, further preferably 16.63%~16.67%.
2. by mass percentage, accounting is 0.51%~0.80%, preferably 0.61% to zinc citrate in the composition ~0.74%, further preferably 0.65%~0.70%.
Secondly, by weight, the multi-vitamins electronics chelates calcium, by parts by weight 1397.73~2329.43 Part calcium citrate, 4.37~7.64 parts of D-VB5 calcium, 2.40~5.20 parts of multivitamin composite powder, 678.12~ 978.12 parts of lactose is homogenized using 1.0%~3.0% sodium carboxymethylcellulose homogeneous and is made.
Preferably, the multi-vitamins electronics chelates calcium, by 1759.52~1966.16 parts of lemon of parts by weight Sour calcium, 5.46~7.64 parts of D-VB5 calcium, 3.32~4.72 parts of multivitamin composite powder, 753.15~903.12 parts Lactose is homogenized using 1.5%~2.5% sodium carboxymethylcellulose homogeneous and is made.
It is further preferred that the multi-vitamins electronics chelates calcium, by 1860.00~1865.84 parts of parts by weight Calcium citrate, 7.36~7.64 parts of D-VB5 calcium, 3.63~4.42 parts of multivitamin composite powder, 826.37~ 829.26 parts of lactose is homogenized using 1.8%~2.2% sodium carboxymethylcellulose homogeneous and is made.
Again, the multivitamin composite powder communicates Over emulsfication homogeneous by water phase, oil, spray drying is made.It is special Sign is: water phase is ascorbic acid, vitamin B1, vitamin B2, starch Sodium Octenyl Succinate, cornstarch, maltodextrin One or more of；Oily is mutually vitamin D3, vitamin E, vitamin A, sunflower oil, one of Glycerin, mixed triester with caprylic acid capric acid or It is several.
Further, the mass percent of the multivitamin composite powder, water phase and oily phase is 10.4~15.9: 84.1~89.6, preferably 11.2~14.0:86.0~88.8, further preferably 12.0~13.4:86.6~88.0.
Still further, the multivitamin composite powder contains vitamin D based on mass percentage3For 0.25%~ 0.55%, preferably 0.25%~0.40%, further preferably 0.25%~0.30%；It is 1%~5% containing ascorbic acid, Preferably 2%~5%, further preferably 3%~4%.
The second object of the present invention is realized by following technical proposals.
Preparation method of composition provided by the invention includes the preparation of multivitamin composite powder, multi-vitamins electronics chelating Calcium preparation, the present composition prepare three steps:
Step 1: the preparation of multivitamin composite powder
The preparation of water phase: aqueous phase substance is mixed and sets kettle, adds appropriate amount of water in 50 DEG C or less low temperature stirring and dissolvings, sufficiently stirs Mix to solution it is uniform, stablize be suspended, 100 mesh filter screens filtration, filtrate heat preservation it is spare.
The preparation of oily phase: oil phase substance being mixed and sets oil cauldron, and 60 DEG C or less low-temperature heats are dissolved to solution clear, The filtration of 100 mesh filter screens, filtrate heat preservation are spare.
Emulsifying homogeneous: it is -0.08~-0.06Mpa that emulsion pot, which is evacuated to vacuum degree, and water phase is evacuated to emulsion pot, is heated It is kept the temperature to 55 DEG C.Maintain vacuum degree constant, the oily phase of suction under stirring, heat preservation, pressure maintaining emulsifying homogeneous 30 minutes, microscopy inclusion rate >= 95% discharging.
Spray drying: emulsifying homogeneous liquid is spray-dried, and multivitamin composite powder, granularity >=100 mesh is made.
Step 2: the chelated calcium preparation of multi-vitamins electronics
1. the multi-vitamins powder of step 1 preparation is mixed with lactose, appropriate amount of water is added to dissolve, 100 mesh filtration, filtrate moves to Homogeneous refiner.
2. calcium citrate mixed 80 meshes with D-VB5 calcium, it is added slowly in homogeneous refiner, is fully ground to paste Shape.
3. sodium carboxymethylcellulose slurrying, standing takes supernatant to be added slowly to homogeneous refiner, adjusts homogeneous refiner To 3000 revs/min, abundant homogeneous is homogenized 30 minutes revolving speed.
4. homogeneous homogenate crushed 80 meshes in 60 DEG C or less low temperature dryings, multi-vitamins electronics chelating calcium is obtained.
Step 3: the preparation of composition
Zinc citrate is crossed 80 meshes and is moved back to three mixing machines, and the multi-vitamins electronics chelating of step 2 preparation is added Calcium, booting mixing 30-45 minutes, range estimation upper, middle and lower layer powder color one to upper, middle and lower layer calcium mass percentage testing result It discharges when RSD≤2%, the present composition is made.
The purpose of third of the present invention, is achieved through the following technical solutions.
Firstly, the present composition contains calcium, zinc and multi-vitamins, multivitamin, mineral nutrient can be used as Source is applied to drug, health food, functional ordinary food, special medicine formula food, special diet food.
Secondly, the present composition can add or not add drug, health food, functional ordinary food, special medicine Formula food, the acceptable auxiliary material of special diet food, are made pulvis, granule, tablet, capsule, soft capsule, capsule and pill, drop A variety of oral preparations such as ball.
The present composition can be used as calcium, zinc and multivitamin source,
Compared to inorganic acid calcium, calcium of organic acid, amino acid calcium and combinations thereof and preparation, the present composition uses for the first time Multi-vitamins electronics chelates calcium as calcium source, has higher bio-dissipative and availability.Fully considering composition spy While determining mutually to cooperate between component nutrient, savings and GI irritation caused by single replenish the calcium are significantly reduced, is realized The technical effect that calcium source efficient absorption utilizes, various nutrients collaboration supplements.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to Limit the present invention.
The preparation 1 of example 1 group conjunction object
Step 1: the preparation 1 of multivitamin composite powder
The preparation of water phase: by vitamin B112mg, matrix starch Sodium Octenyl Succinate 61.5mg, cornstarch 183mg Kettle is set in mixing, adds appropriate amount of water in 50 DEG C or less low temperature stirring and dissolvings, is stirred well to that solution is uniform, stablizes and is suspended, the filter of 100 mesh Net filtration, obtains water phase 256.5mg, and filtrate heat preservation is spare.
The preparation of oily phase: by vitamin D3Oil is set in 0.9mg, vitamin A 0.6mg, matrix Glycerin, mixed triester with caprylic acid capric acid 42mg mixing Pot, 60 DEG C or less low-temperature heats are dissolved to solution clear, and the filtration of 100 mesh filter screens obtains oily phase 43.5mg, and filtrate heat preservation is standby With.
Emulsifying homogeneous: it is -0.08~-0.06Mpa that emulsion pot, which is evacuated to vacuum degree, and water phase is evacuated to emulsion pot, is heated It is kept the temperature to 55 DEG C.Maintain vacuum degree constant, the oily phase of suction under stirring, heat preservation, pressure maintaining emulsifying homogeneous 30 minutes, microscopy inclusion rate >= 95% discharging.
Spray drying: emulsifying homogeneous liquid is spray-dried, obtained multivitamin composite powder 300mg, granularity >=100 mesh, Through detecting vitamin D3Content be 0.3%.
Step 2: the chelated calcium preparation 1 of multi-vitamins electronics
1. the multivitamin composite powder 0.3g of step 1 preparation is mixed with lactose 70g, appropriate amount of water is added to dissolve, the filter of 100 mesh It crosses, filtrate moves to homogeneous refiner.
2. calcium citrate 142g mixed 80 meshes with D-VB5 calcium 0.45g, it is added slowly in homogeneous refiner, sufficiently It is ground to paste.
3. 1.0% sodium carboxymethylcellulose slurrying, standing takes supernatant to be added slowly to homogeneous refiner, and it is even to adjust homogeneous To 3000 revs/min, abundant homogeneous is homogenized 30 minutes pulp grinder revolving speed.
4. homogeneous homogenate crushed 80 meshes in 60 DEG C or less low temperature dryings, multi-vitamins electronics chelating calcium is obtained 212.75g, the content for being detected calcium is 16.12%.
Step 3: the preparation 1 of composition
Zinc citrate 1.4g crosses 80 meshes and moves back to three mixing machines, adds the multi-vitamins electronics chela of step 2 preparation Close calcium 212.75g, booting mixing 30-45 minutes, range estimation upper, middle and lower layer powder color one to upper, middle and lower layer calcium mass percentage It discharges when testing result RSD≤2%, 1 214.15g of the present composition is made, the content for being detected calcium is 16.01%.
The preparation 2 of 2 composition of embodiment
Step 1: the preparation 2 of multivitamin composite powder
The preparation of water phase: by vitamin B25mg, matrix starch Sodium Octenyl Succinate 75mg, maltodextrin 365.5mg are mixed Kettle is set in conjunction, adds appropriate amount of water in 50 DEG C or less low temperature stirring and dissolvings, is stirred well to that solution is uniform, stablizes and is suspended, 100 mesh filter screens Filtration, obtains water phase 445.5mg, and filtrate heat preservation is spare.
The preparation of oily phase: by vitamin D3Oil is set in 2mg, vitamin E 2.5mg, matrix Glycerin, mixed triester with caprylic acid capric acid 50mg mixing Pot, 60 DEG C or less low-temperature heats are dissolved to solution clear, and the filtration of 100 mesh filter screens obtains oily phase 54.5mg, and filtrate heat preservation is standby With.
Emulsifying homogeneous: the preparation method is the same as that of Example 1.
Spray drying: emulsifying homogeneous liquid is spray-dried, obtained multivitamin composite powder 500mg, granularity >=100 mesh, Through detecting vitamin D3Content be 0.4%.
Step 2: the chelated calcium preparation 2 of multi-vitamins electronics
1. the multivitamin composite powder 0.5g of step 1 preparation is mixed with lactose 78g, appropriate amount of water is added to dissolve, the filter of 100 mesh It crosses, filtrate moves to homogeneous refiner.
2. calcium citrate 164.7g mixed 80 meshes with D-VB5 calcium 0.57g, it is added slowly in homogeneous refiner, fills Divide and is ground to paste.
3. 1.8% sodium carboxymethylcellulose slurrying, standing takes supernatant to be added slowly to homogeneous refiner, and it is even to adjust homogeneous To 3000 revs/min, abundant homogeneous is homogenized 30 minutes pulp grinder revolving speed.
4. homogeneous homogenate crushed 80 meshes in 60 DEG C or less low temperature dryings, multi-vitamins electronics chelating calcium is obtained 243.77g, the content for being detected calcium is 16.32%.
Step 3: the preparation 2 of composition
Zinc citrate 1.6g crosses 80 meshes and moves back to three mixing machines, adds the multi-vitamins electronics chela of step 2 preparation Close calcium 243.77g, booting mixing 30-45 minutes, range estimation upper, middle and lower layer powder color one to upper, middle and lower layer calcium mass percentage It discharges when testing result RSD≤2%, 2 245.37g of the present composition is made, the content for being detected calcium is 16.21%.
The preparation 3 of 3 composition of embodiment
Step 1: the preparation 3 of multivitamin composite powder
The preparation of water phase: by ascorbic acid 14.16mg, matrix starch Sodium Octenyl Succinate 118mg, maltodextrin Kettle is set in 274.704mg mixing, adds appropriate amount of water in 50 DEG C or less low temperature stirring and dissolvings, it is uniform, stable mixed to be stirred well to solution Outstanding, the filtration of 100 mesh filter screens obtains water phase 406.864mg, and filtrate heat preservation is spare.
The preparation of oily phase: by vitamin D32.36mg, vitamin E 1.416mg, matrix sunflower oil 61.36mg mixing are set Oil cauldron, 60 DEG C or less low-temperature heats are dissolved to solution clear, and the filtration of 100 mesh filter screens obtains oily phase 65.136mg, and filtrate is protected Warm standby is used.
Emulsifying homogeneous: the preparation method is the same as that of Example 1.
Spray drying: emulsifying homogeneous liquid is spray-dried, obtained multivitamin composite powder 472mg, granularity >=100 mesh, Through detecting vitamin D3Content be 0.5%, ascorbic acid content 3.0%.Step 2: multi-vitamins electronics is chelated calcium Preparation 3
1. the multivitamin composite powder 0.472g of step 1 preparation is mixed with lactose 96.3g, appropriate amount of water is added to dissolve, 100 Mesh filtration, filtrate move to homogeneous refiner.
2. calcium citrate 230g mixed 80 meshes with D-VB5 calcium 0.63g, it is added slowly in homogeneous refiner, sufficiently It is ground to paste.
3. 2.5% sodium carboxymethylcellulose slurrying, standing takes supernatant to be added slowly to homogeneous refiner, and it is even to adjust homogeneous To 3000 revs/min, abundant homogeneous is homogenized 30 minutes pulp grinder revolving speed.
4. homogeneous homogenate crushed 80 meshes in 60 DEG C or less low temperature dryings, multi-vitamins electronics chelating calcium is obtained 327.402g, the content for being detected calcium is 16.96%.
Step 3: the preparation 3 of composition
Zinc citrate 2.07g crosses 80 meshes and moves back to three mixing machines, adds the multi-vitamins electronics of step 2 preparation Chelate calcium 327.402g, booting mixing 30-45 minutes, range estimation upper, middle and lower layer powder color one to the calcareous amount percentage of upper, middle and lower layer It discharges when content detection result RSD≤2%, 3 329.472g of the present composition is made, the content through detecting calcium is 16.85%.
The preparation 4 of 4 composition of embodiment
Step 1: the preparation 4 of multivitamin composite powder
The preparation of water phase: by ascorbic acid 0.32g, matrix starch Sodium Octenyl Succinate 1.36g, maltodextrin 5.268g Kettle is set in mixing, adds appropriate amount of water in 50 DEG C or less low temperature stirring and dissolvings, is stirred well to that solution is uniform, stablizes and is suspended, the filter of 100 mesh Net filtration, obtains water phase 6.948g, and filtrate heat preservation is spare.
The preparation of oily phase: by vitamin D3Oil cauldron is set in 0.02g, vitamin E 0.032g, matrix sunflower oil 1g mixing, 60 DEG C or less low-temperature heats are dissolved to solution clear, and the filtration of 100 mesh filter screens obtains oily phase 1.052g, and filtrate heat preservation is spare.
Emulsifying homogeneous: the preparation method is the same as that of Example 1.
Spray drying: emulsifying homogeneous liquid is spray-dried, obtained multivitamin composite powder 8.00g, granularity >=100 mesh, Through detecting vitamin D3Content be 0.25%, ascorbic acid content 4.0%.Step 2: multi-vitamins electronics chelates calcium Preparation 4
1. the multivitamin composite powder 4.00g of step 1 preparation is mixed with lactose 828.12g, appropriate amount of water is added to dissolve, 100 Mesh filtration, filtrate move to homogeneous refiner.
2. calcium citrate 1863.00g mixed 80 meshes with D-VB5 calcium 7.64g, it is added slowly in homogeneous refiner, It is fully ground to paste.
3. 2.0% sodium carboxymethylcellulose slurrying, standing takes supernatant to be added slowly to homogeneous refiner, and it is even to adjust homogeneous To 3000 revs/min, abundant homogeneous is homogenized 30 minutes pulp grinder revolving speed.
4. homogeneous homogenate crushed 80 meshes in 60 DEG C or less low temperature dryings, multi-vitamins electronics chelating calcium is obtained 2.7kg, the content for being detected calcium is 16.67%.
Step 3: the preparation 4 of composition
Zinc citrate 18.66g crosses 80 meshes and moves back to three mixing machines, adds the multi-vitamins electronics of step 2 preparation Chelate calcium 2.7kg, booting mixing 30-45 minutes, range estimation upper, middle and lower layer powder color one to upper, middle and lower layer calcium mass percentage It discharges when testing result RSD≤2%, 4 2.72kg of the present composition is made, the content for being detected calcium is 16.54%.
Embodiment 5: the preparation of granule
Composition 200g prepared by Example 4 through wet granulation, squeezes sieving, the obtained granule of 50 DEG C of low temperature dryings.
Embodiment 6: the preparation of tablet
Composition 200g prepared by Example 4 adds sodium carboxymethyl starch, PVP K30, Magnesium Stearate proper quantity, warp Mixing, granulation, tabletting, are made tablet.
Embodiment 7: the preparation of capsule
Composition 200g prepared by Example 4 adds suitable amount of sucrose, lactose, microcrystalline cellulose, silica, tristearin Sour magnesium, through mixing, granulation, filling, hard capsule processed.
Embodiment 8: the preparation of dripping pill
Example 4 prepare composition 200g, add appropriate Macrogol 4000, Macrogol 6000, odium stearate, Glycerol, gelatin, polyoxyl 40 stearate through mixing, dissolution, pill, polish obtained dripping pill.
In order to further be illustrated to present composition technical effect, the present invention chooses group prepared by embodiment 4 Conjunction object is test specimen, and number is 6., it is real to choose commercially available low calcium feed, calcium carbonate, calcium gluconate oral solution with effect and the present invention Apply the calcium citrate that example 4 uses, multi-vitamins electronics chelating calcium prepared by embodiment 4 is control sample, 1. number is respectively Commercially available low calcium feed, 2. calcium carbonate, 3. calcium citrate, 4. calcium gluconate oral solution with effect, 5. multi-vitamins electronics chelate calcium, open Calcium apparent absorptivity and the test of calcium storage rate are opened up, as a result as follows:
Calcium apparent absorptivity and storage rate measurement
1. instrument and material
Zoonit700 atomic absorption spectrophotometer: Jena, Germany production
SD rat (Sprague-Dawley): 4 week old, weight 70-80g, cleaning grade；Feeding environment: temperature (22 ± 2) DEG C, humidity 60% ± 5%.Shanghai western Poole-Bi Kai experimental animal Co., Ltd provides
Low calcium feed: commercially available.Calcium content is 0.1%；
Calcium carbonate (analysis is pure): commercially available.Calcium carbonate content is 99.8% (being equivalent to calcium 39.96%)；
Calcium gluconate oral solution with effect: commercially available.100mg/ml containing calcium gluconate (is equivalent to calcium 9mg/ml)
Calcium citrate: (being equivalent to calcium 23.60%) containing calcium citrate 97.84%
Multi-vitamins electronics chelates calcium: calcium content 16.67%
The present composition: calcium content 16.54%
2. experimental method
(1) dosage
Composition (sample is 6.) 60kg adult's dosage is determined as 2.72g/ days, rolls over accordingly according to the present invention Calculating daily rat dosage is 0.283g/kg BW, while 1. group gives isodose deionized water, the dosage such as foundation to sample It is administered daily referring to composition of the present invention (adult human body mass 60kg) than principle (using the dosage of calcium as parameter) Take in calcium content 450mg, conversion control sample daily administration dosage is sample 2. 0.12g/kg BW, sample 3. 0.20g/kg BW, sample 4. 5.21ml/kg BW, sample 5. 0.281g/kg BW.
(2) rat experimental group and feeding patterns
SD rat after a week, selects the weight rat that there was no significant difference 60 through adaptable fed, is divided into 6 groups: low calcium Feed control group (1.), calcium carbonate group (2.), calcium citrate group (3.), calcium gluconate group (4.), multi-vitamins electronics chela Calcium group (5.), composition group (6.) are closed, every group of 1O is only.Each group rat ad lib low calcium feed drinks deionized water, in this base Daily stomach-filling is carried out on plinth to raise 8 weeks.
(3) measurement of calcium apparent absorptivity and storage rate
Rat body weight need to weigh daily, feed to after 4 weeks rat being put into collection 3d excrement, urine to 100 in metabolic cage Dry in DEG C air dry oven, grinds the results are shown in Table 1 using calcium content in Flame Atomic Absorption metabolin after constant weight.
Calcium apparent absorptivity (%)=(intake calcium-excrement calcium)/intake calcium × 100
Calcium storage rate (%)=(intake calcium-excrement calcium-urinary calcium)/intake calcium × 100
1 calcium apparent absorptivity of table and storage rate measurement (N=10)
As shown in Table 1, sample 6. compared to sample 2., 3., the 4. extremely significant reduction (P < 0.01) of excrement calcium content, compared to 5. excrement calcium content significantly reduces (P < 0.05) to sample；Sample 6. compared to sample 2., 3. extremely significant reduction (the P < of urinary calcium content 0.01), compared to sample, 4., 5. urinary calcium content significantly reduces (P < 0.05)；6. compared to sample, 2., 3., 4. calcium is apparent for sample The extremely significant raising (P < 0.01) of absorptivity, calcium storage rate content, compared to sample 5. calcium apparent absorptivity, calcium storage rate content It is significant to increase (P < 0.05)；I.e. 6. (present composition) sample shows that good promotion calcium source is absorbed and utilized and improves calcium The activity of storage rate.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to restrict the invention, all in essence of the invention Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.

Claims (9)

1. a kind of nutrient composition for remarkably promoting calcium source efficient absorption and utilizing chelates calcium, lemon by multi-vitamins electronics Sour zinc composition.It is characterized by:
1. multi-vitamins electronics chelates calcium system and uses sodium carboxymethylcellulose slurrying, by calcium citrate, D-VB5 calcium, Duo Zhongwei Raw element composite powder, lactose are homogenized by homogeneous, and low temperature drying is made.Wherein, calcium mass percentage be 14.14%~ 18.65%, preferably 15.89%~17.40%, further preferably 16.63%~16.67%.
2. by mass percentage, zinc citrate in the composition accounting be 0.51%~0.80%, preferably 0.61%~ 0.74%, further preferably 0.65%~0.70%.
2. multi-vitamins electronics as described in claim 1 chelates calcium, by 1397.73~2329.43 parts of lemon of parts by weight Lemon acid calcium, 4.37~7.64 parts of D-VB5 calcium, 2.40~5.20 parts of multivitamin composite powder, 678.12~978.12 parts Lactose, using 1.0%~3.0% sodium carboxymethylcellulose homogeneous be homogenized be made.
3. as multi-vitamins electronics claimed in claims 1-2 chelates calcium, by 1759.52~1966.16 parts of parts by weight Calcium citrate, 5.46~7.64 parts of D-VB5 calcium, 3.32~4.72 parts of multivitamin composite powder, 753.15~903.12 The lactose of part is homogenized using 1.5%~2.5% sodium carboxymethylcellulose homogeneous and is made.
4. the multi-vitamins electronics as described in claim 1-3 chelates calcium, by 1860.00~1865.84 parts of parts by weight Calcium citrate, 7.36~7.64 parts of D-VB5 calcium, 3.63~4.42 parts of multivitamin composite powder, 826.37~829.26 The lactose of part is homogenized using 1.8%~2.2% sodium carboxymethylcellulose homogeneous and is made.
5. the multivitamin composite powder as described in claim 1-4 communicates Over emulsfication homogeneous by water phase, oil, spray drying is made ?.It is characterized by: water phase is ascorbic acid, vitamin B1, vitamin B2, starch Sodium Octenyl Succinate, cornstarch, wheat One or more of bud dextrin；Oily is mutually vitamin D3, vitamin E, vitamin A, sunflower oil, in Glycerin, mixed triester with caprylic acid capric acid It is one or more of.
6. multivitamin composite powder as claimed in claim 5, it is characterised in that: the mass percent of water phase and oily phase is 10.4~15.9:84.1~89.6, preferably 11.2~14.0:86.0~88.8, further preferably 12.0~13.4:86.6 ~88.0.
7. the multivitamin composite powder as described in claim 5-6, it is characterised in that: based on mass percentage, contain vitamin D3 It is 0.25%~0.55%, preferably 0.25%~0.40%, further preferably 0.25%~0.30%；It is containing ascorbic acid 1%~5%, preferably 2%~5%, further preferably 3%~4%.
8. the nutrient composition as described in claim 1-7, it is characterised in that: the composition can be used as multivitamin, mine Material nutrition usually source is applied to drug, health food, functional ordinary food, special medicine formula food, special diet food Product.
9. the nutrient composition as described in claim 1-8, it is characterised in that: the composition can add or not add drug, Health food, functional ordinary food, special medicine formula food, the acceptable auxiliary material of special diet food, be made pulvis, The many kinds of solids oral preparation such as granula, tablet, capsule, soft capsule, capsule and pill, dripping pill.
CN201910385236.4A 2019-05-09 2019-05-09 It is a kind of to remarkably promote the nutrient composition and preparation that calcium source efficient absorption utilizes Pending CN110150673A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1408363A (en) * 2002-07-31 2003-04-09 北京世纪劲得保健品有限公司 Equalizing nutrient effervescent tablet and its preparing method
CN102716087A (en) * 2012-05-31 2012-10-10 浙江中同科技有限公司 Vitamin powder and preparation method thereof
CN104187624A (en) * 2014-08-07 2014-12-10 逯明福 Comprehensive nutrition powder and preparation method thereof
US20160278415A1 (en) * 2015-01-30 2016-09-29 Nutrient Foods, Llc Food Compositions Containing All Essential Nutrients
US20160324204A1 (en) * 2015-01-22 2016-11-10 Mingfu LU Complete Nutritional Powder and Preparation Method Thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1408363A (en) * 2002-07-31 2003-04-09 北京世纪劲得保健品有限公司 Equalizing nutrient effervescent tablet and its preparing method
CN102716087A (en) * 2012-05-31 2012-10-10 浙江中同科技有限公司 Vitamin powder and preparation method thereof
CN104187624A (en) * 2014-08-07 2014-12-10 逯明福 Comprehensive nutrition powder and preparation method thereof
US20160324204A1 (en) * 2015-01-22 2016-11-10 Mingfu LU Complete Nutritional Powder and Preparation Method Thereof
US20160278415A1 (en) * 2015-01-30 2016-09-29 Nutrient Foods, Llc Food Compositions Containing All Essential Nutrients

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Application publication date: 20190823