CN1408363A - Equalizing nutrient effervescent tablet and its preparing method - Google Patents
Equalizing nutrient effervescent tablet and its preparing method Download PDFInfo
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- CN1408363A CN1408363A CN 02125868 CN02125868A CN1408363A CN 1408363 A CN1408363 A CN 1408363A CN 02125868 CN02125868 CN 02125868 CN 02125868 A CN02125868 A CN 02125868A CN 1408363 A CN1408363 A CN 1408363A
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Abstract
The equalizing nutrient effervescent tablet is prepared with nutrient matters containing vitamins and trace elements and capable of providing human body with essential nutrient matters. It has its acid and alkali nutrient matters separately embedded. It has the advantages of long guarantee period, good taste, easy absorption and capacity of providing equalized nutrients.
Description
Technical field
The present invention relates to a kind of supplementary, particularly relate to a kind of equalizing nutrient effervescent tablet and preparation method thereof.
Background technology
All kinds of in the market nutrient prime replenisher sales volumes are considerable, but all have many problems.Common has:
1), prescription not exclusively, nutrition is unbalanced;
Replenish the calcium merely, ferrum, zinc class: the effect of the single nutrient of lay special stress on such as calcium, ferrum or zinc, and ignored the ubiquitous calcium deficiency of Chinese, ferrum, VA, VC, VB
2, Zn the fact, especially unilateral heavy dose is replenished the absorption that one nutrient may influence other nutrients.
The compound nutrients sheet is (as Theragran, Centrum etc.): this series products is with Theragran, Centrum is representative, from abroad, be basic research with Hesperian human body situation all, ubiquity is not suitable for Chinese prescription problem, as in the product every contain VA5000IU, VD400IU, replenishing so a large amount of general Chinese of fatsoluble vitamin every day can not be so a large amount of, might cause some potential safety issues.In addition, seldom contain mineral and trace element such as calcium that Chinese more need, ferrum, zinc in this series products.
2), prescription is out-of-date;
At present the vitamin products of prescription are mainly offshore company and produce, just applied for domestic medicine certificate before the more than ten years, fill a prescription to before the external more than ten years or even exploitation decades ago, do not make full use of the achievement in research of modern field of nutrition in recent years.
3), absorption is relatively poor;
Present supplementary mostly adopts the dosage form of swallowing, and enters often disintegrate fully behind the digestive tract, causes suitable nutrient not dissolve fully, absorbs relatively poor.
By last analysis as can be seen, research and develop a kind of be fit to Chinese, comprehensive nutrition is balanced, the supplementary of easy absorption, just seems very necessary.
At present the compound nutrients effervescent tablet all is that German product is general or be vitamin basically in the similar products at home and abroad, or be trace element, does not contain multivitamin and trace element simultaneously.This mainly be because: the interpolation simultaneously of vitamin and trace element can react, and it is very poor to add so many nutrient taste, and consumer is difficult to accept.
Microcapsule technology belongs to the embedding techniques of medical technical field, and it is technology, the new technique of nearly 30 years drug application, and it utilizes natural macromolecular material as cyst membrane wall shell, with Drug Storage shape microcapsule solid-state or that the liquid drug parcel forms, is called for short microcapsule.Microcapsule is the new technology of medicinal application in recent years, an outstanding representative in the new technique.The tenth secondary microencapsulation international conference that in JIUYUE, 1999 is held in London, to the microencapsulation of peptide class, protein drug, new method, the new technology of research microcapsule structure are used for orally to nanocapsule, and all there is significant progress aspects such as pulmonary or non-intestinal mucosa.
The microcapsule technique for packing of equalizing nutrient effervescent tablet application of advanced of the present invention is to solve the problems that exist in the production.
The microcapsule packaging method is a lot, we are according to raw material properties, has adopted complex coacervation in the physico-chemical process and the spray drying method in the physical dryness method respectively.
Complex coacervation is as the capsule material with arabic gum, gelatin, raw material is scattered in the capsule material, with the gelatin solution pH value from transferring to more than the isoelectric point, IP below the isoelectric point, IP, make it positively charged (pH value 4.0-4.5), and arabic gum is still electronegative, because electric charge attracts each other and is cross-linked into the complex of positive and negative electric charge, dissolubility reduces and the cohesion encystation.In complex coacervation, want the strict sour speed of controlling when transferring pH value that adds, arabic gum and gelatin are slowly condensed, film forming is even, adding arabic gum should constantly stir, acid is uniformly dispersed, help arabic gum, gelatin progressively wraps up, solution temperature remains at 50-55 ℃, this liquid is more than congealing point, the gelatin viscosity reduces, help aggregation, microcapsule forms i.e. cooling, dilute with water, stop aggregation, make gelatin viscosity increase the cyst membrane typing, be cooled at last below 5 ℃, cyst membrane is finalized the design fully.Add formaldehyde and solidify and must under alkali condition gelatin molecule is cross-linked with each other, PH8-9 be crosslinked fully.Add acrylic resin simultaneously and make compact agent,, solve the leakage material problem of cyst membrane with the hole of the few cyst membrane of alkali.
Spray drying method is that raw material is dispersed in the capsule material solution, in inert thermal current, the solution of pocket material is evaporated rapidly, and the capsule material shrinks, and forms semi-transparent film on the raw material surface.Microcapsule falls into catcher after cyclonic separation, the about 5 μ m-600 μ m of the microcapsule diameter that makes like this.
Spray drying method, equipment comprises steam device, spray gun, spray chamber, blower, exhaust fan, cyclone dust extractor, product catcher, and key will be controlled the viscosity uniformity, raw material and the concentration of material of mixed liquor, speed, spray method and the dry rate etc. of spraying aborning.Dry rate is by the concentration and the out temperature decision of mixed liquor, and capsule core material can not wrap up too greatly, because cyst membrane is with holes, the products obtained therefrom bulk density is less.
The microcapsule static electrification easily causes adhesion, also be so at drying stage, so the Polyethylene Glycol that adds solubility in the capsule material can reduce adhesion as antiplastering aid.Adopt continuous nebulization can reduce the adhesion of microcapsule.
Summary of the invention
The objective of the invention is to overcome the above-mentioned shortcoming of prior art, a kind of long shelf-life is provided, mouthfeel is good, and can provide balanced nutritious equalizing nutrient effervescent tablet for human body.
The present invention also aims to provide the preparation method of this equalizing nutrient effervescent tablet.
For achieving the above object, equalizing nutrient effervescent tablet of the present invention is by making for human body provides balanced nutritious nutrient substance, and the acid that reacts to each other easily, alkali two class nutrient substance are to carry out embedding respectively, and described nutrient substance comprises multivitamin and trace element
As optimization, have differently smell flavor, meet light or in air easily oxidized nutrient substance also carry out embedding.
As optimization, described embedding mode is a microcapsule.
As optimization, described nutrient substance comprises:
VitA, VitB
1, VitB
2, VitB
6, VitB
12, VitPP (biotin), VitC, VitD, VitE, VitK, folic acid, pantothenic acid, Ca, Fe, Zn, Se, Cr, P, taurine, Mn, lycopene.
As optimization, the weight proportion of described nutrient substance is:
VitA 0.1-1; VitB
10.2-2; VitB
20.2-2; VitB
60.2-2; VitB
120.0002-0.002; VitPP (biotin) 2-20; VitC 10-200; VitD0.001-0.02; VitE 5-100; VitK 0.005-0.1; Folic acid 0.05-0.5; Pantothenic acid 1-10; Ca 50-500; Fe 2-10; Zn 2-10; Se 0.005-0.1; Cr 0.005-0.1; P 0.05-0.4; Taurine 0 or 10-100; Mn0 or 0.5-5; Lycopene 0 or 10-200.
As optimization, described pantothenic acid, Ca, Fe, Zn, Se, Cr, the existence form of P is respectively a calcium pantothenate, CaCO
3, NaFeEDTA or ferric phrophosphate, zinc lactate, sodium selenate, Chlorizate chromium, calcium hydrogen phosphate or potassium dihydrogen phosphate.
As optimization, its raw material also comprises other auxiliary material.
As optimization, described auxiliary material comprises or is selected from following raw materials according:
Citric acid, malic acid, sodium bicarbonate, aspartame, the peace thiophene is phonetic, beta-carotene, flavoring orange essence, ethyl maltol, Polyethylene Glycol, glucose, PVP (acrylic resin), dehydrated alcohol.
The preparation method of equalizing nutrient effervescent tablet of the present invention is to make effervescent tablet for human body provides balanced nutritious nutrient substance, and is to carry out embedding respectively to acid, the alkali two class nutrient substance that react to each other easily.
As optimization, differently smell flavor to having, meet light or in air easily oxidized nutrient substance also carry out embedding, described embedding mode is to make microcapsule.
The balanced effervescent tablet of the present invention contains necessary nutrient and the various adjuvants of human body such as multivitamin, ferrum, zinc, taurine, to regulate mouthfeel, numerous elements can be suppressed in flakes, evenly be dissolved in the water, be convenient to absorption of human body, increase operation rate, contain the foreign odor flavor as ferrum, zinc what from multielement, have; Chemical change takes place in element in process of production mutually that have, even causes variable color, and the element that has is owing to chance light or in air easily oxidized (as vitamin); Because this product is to utilize acid, alkali to produce chemical change, produce carbon dioxide, in the effervescent process, make multiple element dissolving, therefore, acid, alkali be present in simultaneously be easy in the tablet take place chemical negative side should so that can't suppress in flakes, therefore in order to address the above problem, in process of production, some element is adopted micro-capsule package technology, to reach its intended purposes.
Owing to adopted embedding techniques, make the various raw materials in the balanced sheet can keep its stability (acid-base raw materials does not react to each other), reduce aerial oxidation, particularly vitamins.Cover the solubility property of raw material, thereby improved the solubility of product, improved absorbance.Be convenient to the adjustment of mouthfeel etc., thereby improve the quality of product.
With battalion defend cooperation in we have utilized novel medicament preparation micro-encapsulation technology the embedding respectively of granulates, alkali granule, vitamin, trace element, make nutrient effervescent tablets, avoided between the soda acid, reacting to each other between vitamin and the trace element, prolonged the holding time.Simultaneously, because effervescent becomes one glass of good to eat beverage before taking, nutrient is fully dissolving in water, has improved the absorbance of nutrient.In addition, micro-encapsulation technology has also solved ferrum and zinc influence taste in beverage problem, make effervescent tablet of the present invention become nutrition good, delicious, absorb better nutrient prime replenisher, be subjected to the popular welcome of consumer.Wherein:
1, child form:
A, solved the most general nutrition problem of Chinese----calcium deficiency.Every calcic 220mg is in one bag of milk, phosphorous 110mg simultaneously, and calcium phosphorus ration is suitable, is more conducive to the growth promoter of child's skeleton.
B, the solution the most serious nutrition problems of Chinese----iron deficiency.Every iron content 8mg, the form of EDTA complexation ferrum, easier absorption.Iron deficiency can cause anemia, influences baby's early intelligence and grows, and the student is absent minded on class, and achievement descends.
The problem----intelligence development that c, the solution head of a family pay close attention to the child most.Add taurine 50mg and zinc 6mg.All help the growth of child's nerve, improve intelligence.Zinc can also improve child's anorexia, and advance growth is grown.
D, balanced Replacement Battalion shape improve comprehensively and grow (20 kinds vitamin and mineral).
E, effervescent dosage form, easier absorption.
Do not contain sodium common in other effervescent tablets (risk factors for hypertension) in f, the product, product is healthy more.
2, adult type:
A, balanced prescription replenish 22 kinds of necessary vitamin of human body and mineral comprehensively, help keeping abundant energy.
B, be rich in the antioxidation nutrient,, add the strongest lycopene of antioxidation in the food, help the naturally-aged of human body opposing cell according to newest research results.
The chemical liver injury that c, antioxidation element can prevent ethanol to cause.
D, effervescent dosage form, easier absorption.
Do not contain sodium common in other effervescent tablets (risk factors for hypertension) in e, the product, product is healthy more.
The specific embodiment
Below in conjunction with example, the present invention is further illustrated:
The weight proportion of its raw material is:
Nutrient title proportioning (unit is a gram) child form/sheet adult type/sheet
VitA 0.1、0.5、1； 350μg 400μg
VitB
1 0.2、1、2； 0.5mg 0.8mg
VitB
2 0.2、1、2； 0.5mg 0.8mg
VitB
6 0.2、1、2； 0.4mg 0.6mg
VitB
12 0.0002、0.001、0.002； 0.6μg 1.2μg
VitPP (biotin) 2,10,20; 5mg 8mg
VitC 10、55、200； 30mg 50mg
VitD 0.001、0.01、0.02； 5μg 2.5μg
VitE 5、50、100； 15mg 30mg
VitK 0.005、0.01、0.1； 10μg 20μg
Folic acid 0.05,0.2,0.5; 100 μ g, 200 μ g
Pantothenic acid (calcium pantothenate) 1,5,10; 2mg 2.5mg
Ca (calcium carbonate) 50,200,500; 220mg 220mg
Fe(NaFeEDTA)2、5、10； 4mg 4mg
Zn (zinc lactate) 2,5,10; 6mg 7.5mg
Se (sodium selenate) 0.005,0.05,0.1; 10 μ g, 30 μ g
Cr (Chlorizate chromium) 0.005,0.01,0.1; 25 μ g, 30 μ g
P (calcium hydrogen phosphate or potassium dihydrogen phosphate)
0.05、0.1、0.4； 150mg 150mg
Taurine 0 or 10,50,100; 50mg
Mn 0 or 0.5,2,5; 2.5mg
Lycopene 0 or 10,100,200.25mg
The consumption of other auxiliary materials can be grasped flexibly, and its content of every can be:
Citric acid 1250mg, malic acid 400mg, sodium bicarbonate 571mg, aspartame 25mg, the phonetic 25mg of peace thiophene, beta-carotene 0.25mg, flavoring orange essence 80mg, ethyl maltol 22mg, Polyethylene Glycol 250mg, glucose 459mg, PVP 1.3mg, dehydrated alcohol 35mg.
Its preparation method: comprise that acid, alkali two class nutrient substance to reacting to each other easily are to carry out embedding respectively, and differently smell flavor to having, meet light or in air easily oxidized nutrient substance also carry out embedding, described embedding mode is to make microcapsule.
The preparation method of described microcapsule is: use arabic gum, gelatin as the capsule material, raw material is scattered in the capsule material, with the gelatin solution pH value from transferring to more than the isoelectric point, IP below the isoelectric point, IP, make it positively charged (pH value 4.0-4.5), and arabic gum is still electronegative, because electric charge attracts each other and is cross-linked into the complex of positive and negative electric charge, dissolubility reduces and the cohesion encystation.In complex coacervation, want the strict sour speed of controlling when transferring pH value that adds, arabic gum and gelatin are slowly condensed, film forming is even, adding arabic gum should constantly stir, acid is uniformly dispersed, help arabic gum, gelatin progressively wraps up, solution temperature remains at 50-55 ℃, this liquid is more than congealing point, the gelatin viscosity reduces, help aggregation, microcapsule forms i.e. cooling, dilute with water, stop aggregation, make gelatin viscosity increase the cyst membrane typing, be cooled at last below 5 ℃, cyst membrane is finalized the design fully.Add formaldehyde and solidify and must under alkali condition gelatin molecule is cross-linked with each other, PH8-9 be crosslinked fully.Add acrylic resin simultaneously and make compact agent,, solve the leakage material problem of cyst membrane with the hole of the few cyst membrane of alkali.The microcapsule that raw material forms through parcel back respectively is through detecting, the mensuration of the envelop rate of raw material and rate of release etc. in the mensuration of the particle diameter of microcapsule, microcapsules medicine Determination on content, the microcapsule, qualified after, become balanced tablet with other mixed raw material.
Other steps also have:
(1) preprocessing raw material and auxiliary material
Citric acid, malic acid, potassium dihydrogen phosphate, potassium bicarbonate, anhydrous glucose, taurine, vitamin C, vitamin B
6Pulverized 80 mesh sieves.
(2) granulate: (by 10,000 in every material)
1, takes by weighing citric acid according to the production prescription and mixed 40 mesh sieves with calcium carbonate and potassium dihydrogen phosphate, add mix homogeneously in the V-Mixer, incorporation time is 20 minutes, take out and add the 10%PVP ethanol solution, be mixed and made into suitable soft material, soft material is granulated with 20 order stainless steel meshs, wet granular is 50-55 ℃ of drying in electric oven, about 2-3 hour, dried granule is with 20 eye mesh screen granulate, write bucket after dried granule is weighed and sign, indicate the name of an article, lot number, weight, date of operation and operator, be placed on appointed positions.
2, take by weighing vitamin A, the vitamin B of recipe quantity
1, vitamin B
2, vitamin B
6, vitamin B
12, vitamin PP, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, calcium pantothenate, zinc lactate, taurine, with glucose according to equivalent dilution method mix homogeneously, cross 40 mesh sieves.
3, mixture 2 with citric acid, malic acid, mixed 40 mesh sieves, add mix homogeneously in the V-Mixer, incorporation time is 20 minutes, take out back adding dehydrated alcohol and be mixed and made into suitable soft material, soft material is with 16 order nylon wire granulate, write bucket after weighing and sign, indicate the name of an article, lot number, weight, date of operation and operator, be placed on appointed positions.
4, take by weighing biotin with glucose by the dilution method mix homogeneously that progressively increases, cross 80 mesh sieves.Add aspartame, flavoring orange essence, carotene mix homogeneously are crossed 80 mesh sieves.
5, take by weighing sodium bicarbonate and 4 mix homogeneously, cross 80 mesh sieves.
6, take by weighing after granule 1,3 and mixture 5 mix, put mix homogeneously in the V-Mixer, incorporation time 20 minutes is loaded in the double-layer plastic bag, writes bucket and signs, and indicates the name of an article, lot number, weight, date of operation and operator.Put two bags of silica gel in the bag.Bag mouth is bent to be pricked, and is placed on appointed positions.
(3) tabletting:
With 21 stamping machines, the plane punch tabletting of diameter 25mm.Every 4.0 gram, sheet heavily is controlled at+5%-5%.The face THICKNESS CONTROL is at 5.8-6mm, and unilateral must not have tangible sticking phenomenon.
(4) packing
Pack 6 of every plates with aluminum-aluminum blister packaging machine.The requirement pressing is tight, and cutting is neat, and gas leakage, collapse phenomenon must not be arranged.
(5) outer package
Box in the dress, 30 in every box is adorned big case, box in every case 36.Use the adhesive tape joint sealing.
(6) product inspection warehouse-in
(7) fill in protocol, the site clearing.
Three, operation notice:
1, taking acid, alkali to granulate used container respectively should be separately strict, can not obscure, in order to avoid produce reaction.
2, acid, alkali wet granular should be distinguished drying, produce reaction in order to avoid mix.
3,, therefore, after the diluted mixture of must taking to progressively increase is even, mix with other raw material again because this product is a multivitamin, and dosage is little.Behind multivitamin elder generation and the glucose mix homogeneously, mix with anhydrous citric acid, malic acid again.
4, baking temperature is strict controlled under the low temperature, in order to avoid vitamin is subjected to heat damage.
5, because the dried granule therefore unsuitable disposable granulate of the moisture absorption very easily, should a small amount of earlier granulate, tabletting limit, limit granulate is in case dried granule is in the lay up period moisture absorption.According to the pellet moisture situation, dry again to acid, alkali granule in case of necessity.
6, should note mix homogeneously because the adjuvant that adds is more.This product very easily produces sticking, and therefore Ying Qin changes drift in operation.
7, the humidity of strictly controlled environment in whole process of production reduces personnel's discrepancy as far as possible.Should be in the time of must coming in and going out with closing the door.
Note wearing masks when 8, operating, altex glove, glove should in time be changed if any breakage.
Attached: operation 2,3 combination processes:
1, takes by weighing VA, VB according to recipe quantity
1, VB
2, VB
6, VB
12, VC, VD, VE, VK, VPP, folic acid and calcium pantothenate mix homogeneously, cross 40 mesh sieves, cross 40 mesh sieves with the about 0.5kg mix homogeneously of the glucose of equivalent again.
2, take by weighing ferric phrophosphate, zinc lactate, taurine and 1 mix homogeneously, cross 40 mesh sieves, the glucose mix homogeneously of adding is crossed 40 mesh sieves, adds remaining glucose mix homogeneously, crosses 40 mesh sieves.
3, take by weighing citric acid and malic acid and 2 mix homogeneously, cross 40 mesh sieves.
4, mixture 3 is put mix homogeneously in the V-Mixer, incorporation time is 20 minutes.
Claims (10)
1, a kind of equalizing nutrient effervescent tablet is characterized in that the acid that reacts to each other easily, alkali two class nutrient substance are to carry out embedding respectively by making for human body provides balanced nutritious nutrient substance, and described nutrient substance comprises multivitamin and trace element
2, equalizing nutrient effervescent tablet according to claim 1, it is characterized in that having differently smell flavor, meet light or in air easily oxidized nutrient substance also carry out embedding.
3, equalizing nutrient effervescent tablet according to claim 1 is characterized in that described embedding mode is a microcapsule.
4, equalizing nutrient effervescent tablet according to claim 1 is characterized in that described nutrient substance comprises:
VitA, VitB
1, VitB
2, VitB
6, VitB
12, VitPP (biotin), VitC, VitD, VitE, VitK, folic acid, pantothenic acid, Ca, Fe, Zn, Se, Cr, P, taurine, Mn, lycopene.
5, equalizing nutrient effervescent tablet according to claim 4 is characterized in that the weight proportion of described nutrient substance is:
VitA 0.1-1; VitB
10.2-2; VitB
20.2-2; VitB
60.2-2; VitB
120.0002-0.002; VitPP (biotin) 2-20; VitC 10-200; VitD0.001-0.02; VitE 5-100; VitK 0.005-0.1; Folic acid 0.05-0.5; Pantothenic acid 1-10; Ca 50-500; Fe 2-10; Zn 2-10; Se 0.005-0.1; Cr 0.005-0.1; P 0.05-0.4; Taurine 0 or 10-100; Mn0 or 0.5-5; Lycopene 10-200.
6, equalizing nutrient effervescent tablet according to claim 5 is characterized in that described pantothenic acid, Ca, and Fe, Zn, Se, Cr, the existence form of P is respectively a calcium pantothenate, CaCO
3, NaFeEDTA, zinc lactate, sodium selenate, Chlorizate chromium, calcium hydrogen phosphate or potassium dihydrogen phosphate.
7,, it is characterized in that its raw material also comprises other auxiliary material according to claim 1,2,3,4,5 or 6 described equalizing nutrient effervescent tablets.
8, equalizing nutrient effervescent tablet according to claim 7 is characterized in that described auxiliary material comprises or is selected from following raw materials according:
Citric acid, malic acid, sodium bicarbonate, aspartame, the peace thiophene is phonetic, beta-carotene, flavoring orange essence, ethyl maltol, Polyethylene Glycol, glucose, PVP, dehydrated alcohol.
9, the preparation method of equalizing nutrient effervescent tablet of the present invention is characterized in that and can make effervescent tablet for human body provides balanced nutritious nutrient substance, and is to carry out embedding respectively to acid, the alkali two class nutrient substance that react to each other easily.
10, the preparation method of equalizing nutrient effervescent tablet according to claim 9, it is characterized in that differently smelling flavor to having, meet light or in air easily oxidized nutrient substance also carry out embedding, described embedding mode is to make microcapsule.
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|---|---|---|---|
| CN 02125868 CN1408363A (en) | 2002-07-31 | 2002-07-31 | Equalizing nutrient effervescent tablet and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02125868 CN1408363A (en) | 2002-07-31 | 2002-07-31 | Equalizing nutrient effervescent tablet and its preparing method |
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| Publication Number | Publication Date |
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Family
ID=4745680
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005011639A3 (en) * | 2003-07-17 | 2005-04-14 | Menarini Int Operations Lu Sa | Effervescent pharmaceutical compositions containing vitamin d, calcium and phospate and their therapeutic use |
| CN102178266A (en) * | 2011-04-14 | 2011-09-14 | 吉林大学 | Quick-dissolving egg effervescent tablet |
| JP2014240379A (en) * | 2013-05-16 | 2014-12-25 | 大正製薬株式会社 | Solid preparations |
| CN104248036A (en) * | 2014-09-19 | 2014-12-31 | 青海诺蓝杞生物科技开发有限公司 | Lycium ruthenicum Murr procyanidine effervescent tablet and production method thereof |
| CN105495263A (en) * | 2015-12-15 | 2016-04-20 | 北京农学院 | Tomato effervescent tablet and process thereof |
| CN107753507A (en) * | 2016-08-22 | 2018-03-06 | 宜兴市江山生物科技有限公司 | Multivitamin and mineral substance composite effervescent tablet and preparation method thereof |
| WO2018154383A1 (en) * | 2017-02-21 | 2018-08-30 | DA SILVA, João Carlos, Pinho | Compound and method of measuring intestinal permeability and leaky gut |
| CN109843270A (en) * | 2016-10-20 | 2019-06-04 | 固荣私人有限公司 | Oral drug preparation |
| CN110123836A (en) * | 2019-05-20 | 2019-08-16 | 昆明朗盛生物科技有限公司 | The application of calcium zinc vitamin D pantothenic acid piece |
| CN110150673A (en) * | 2019-05-09 | 2019-08-23 | 昆明朗盛生物科技有限公司 | It is a kind of to remarkably promote the nutrient composition and preparation that calcium source efficient absorption utilizes |
-
2002
- 2002-07-31 CN CN 02125868 patent/CN1408363A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005011639A3 (en) * | 2003-07-17 | 2005-04-14 | Menarini Int Operations Lu Sa | Effervescent pharmaceutical compositions containing vitamin d, calcium and phospate and their therapeutic use |
| CN102178266A (en) * | 2011-04-14 | 2011-09-14 | 吉林大学 | Quick-dissolving egg effervescent tablet |
| JP2014240379A (en) * | 2013-05-16 | 2014-12-25 | 大正製薬株式会社 | Solid preparations |
| CN104248036A (en) * | 2014-09-19 | 2014-12-31 | 青海诺蓝杞生物科技开发有限公司 | Lycium ruthenicum Murr procyanidine effervescent tablet and production method thereof |
| CN105495263A (en) * | 2015-12-15 | 2016-04-20 | 北京农学院 | Tomato effervescent tablet and process thereof |
| CN107753507A (en) * | 2016-08-22 | 2018-03-06 | 宜兴市江山生物科技有限公司 | Multivitamin and mineral substance composite effervescent tablet and preparation method thereof |
| CN109843270A (en) * | 2016-10-20 | 2019-06-04 | 固荣私人有限公司 | Oral drug preparation |
| WO2018154383A1 (en) * | 2017-02-21 | 2018-08-30 | DA SILVA, João Carlos, Pinho | Compound and method of measuring intestinal permeability and leaky gut |
| CN110150673A (en) * | 2019-05-09 | 2019-08-23 | 昆明朗盛生物科技有限公司 | It is a kind of to remarkably promote the nutrient composition and preparation that calcium source efficient absorption utilizes |
| CN110123836A (en) * | 2019-05-20 | 2019-08-16 | 昆明朗盛生物科技有限公司 | The application of calcium zinc vitamin D pantothenic acid piece |
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