CN1101184C - Process for preparing medical particles Qingkailing by wrapping chololic acid and animal extract with cyclodextrin - Google Patents
Process for preparing medical particles Qingkailing by wrapping chololic acid and animal extract with cyclodextrin Download PDFInfo
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- CN1101184C CN1101184C CN99112844A CN99112844A CN1101184C CN 1101184 C CN1101184 C CN 1101184C CN 99112844 A CN99112844 A CN 99112844A CN 99112844 A CN99112844 A CN 99112844A CN 1101184 C CN1101184 C CN 1101184C
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- extractum
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- cholic acid
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- benexate hydrochloride
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Abstract
The present invention relates to a technology for preparing medical particles Qingkailing by wrapping chololic acid and animal extract with cyclodextrin, which is characterized in that cholic acid is added in ethanol, and a pH value is regulated to 9 through sodium hydroxide, and beta-cyclodextrin is added to obtain a clathrate compound after dissolution. Buffalo horn and nacre are hydrolyzed and concentrated to make extractum, and beta-cyclodextrin is added to make a raw material of the clathrate compound, and then, gardenia, isatis root, extract of honeysuckle, baicalin and supplementary materials are added; the materials are pelletized and dried to make Qingkailing particles. The product has the advantages of enhancement of bioavailability and good taste in the mouth. The present invention is especially suitable for children to take, and has very high practicability.
Description
Technical field: the present invention relates to the preparation method of a kind of heat-clearing and toxic substances removing, tranquillizing and allaying excitement medicine.
Background technology: Qingkailing granule is the dosage form of developing in recent years, this product has the effect of heat-clearing and toxic substances removing, tranquillizing and allaying excitement, be applicable to the high fever that causes by epidemic febrile disease, disease such as dysphoria, laryngopharynx swelling and pain, the curative effect height, side effect is little, is classified as essential drugs by health ministry, is the clinical acute disease medication.But because cholic acid and animal extractum in the composition of this product have bitterness, and have off-odor, bring discomfort to the patient, particularly child patient is difficult to use.
Summary of the invention: the objective of the invention is to propose a kind ofly to prepare the technology of Qingkailing granule, adopt this technology can eliminate this medicine bitterness and abnormal flavour, improve bioavailability of medicament with cyclodextrin inclusion compound cholic acid and animal extractum.The present invention is on the basis of existing production Qingkailing granule, adopt beta-cyclodextrin inclusion compound cholic acid and animal extractum, mix with Radix Isatidis, Fructus Gardeniae, Flos Lonicerae extract, baicalin and adjuvant again, granulation, drying are made Qingkailing granule, it is characterized in that: Hyodeoxycholic Acid, taurine add in the alcoholic solution, transfer pH value to 9 with 20% sodium hydroxide, after the dissolving, make the cholic acid Benexate Hydrochloride fully with beta-schardinger dextrin-; Cornu Bubali, Concha Margaritifera Usta hydrolysate are condensed into extractum, make animal extractum Benexate Hydrochloride with beta-schardinger dextrin-; Spray powder, cholic acid Benexate Hydrochloride, animal extractum Benexate Hydrochloride, Icing Sugar, the dextrin of Flos Lonicerae, Radix Isatidis, Fructus Gardeniae extract are mixed, adding baicalin becomes saline solution fully to mix, make granule with 75% ethanol, drying is made Qingkailing granule.Said cholic acid Benexate Hydrochloride, its molar ratio, cholic acid: beta-schardinger dextrin-=1: 0.8-3.0.Said animal extractum Benexate Hydrochloride, its weight ratio that feeds intake, animal extractum: beta-schardinger dextrin-=1: 1-5.The Benexate Hydrochloride preparation technology of cholic acid among the present invention and animal extractum: cholic acid Benexate Hydrochloride preparation: by ratio requirement, taurine and Hyodeoxycholic Acid are placed 2 times of amount 75% alcoholic solution, transfer pH value to 9 to make its CL with 20% sodium hydroxide.1, polishing: after beta-schardinger dextrin-ground well with 2 times of deionized waters, add above-mentioned cholic acid alcoholic solution and grind, drying is pulverized, and makes the cholic acid clathrate; 2, full Heshui solwution method: above-mentioned cholic acid alcoholic solution is added in the full Heshui solution of beta-schardinger dextrin-, stirred 90 minutes at 60 ℃, put cold putting more than 24 hours in the refrigerator with the magnetic force heating stirrer, sucking filtration is collected solids, drying, pulverize, make the cholic acid clathrate; 3, colloid milling: above-mentioned cholic acid alcoholic solution is added beta-schardinger dextrin-, milled 15 minutes with colloid mill, the colloid mill face gap 5 μ m that rub, rotating speed 1500 commentariess on classics/min, drying, pulverizing promptly gets the cholic acid clathrate.Animal extractum (Cornu Bubali, Concha Margaritifera) Benexate Hydrochloride preparation: animal extractum preparation: water intaking horn powder, stir slowly to be added on down to be heated in 8 times of amount 4mol/l barium hydroxide solutions and boil, stir and keep little boiling 6-7 hour down, at any time add the deionized water filtered while hot, twice of small amount of thermal water washing of filtering residue, filter, merging filtrate is standby; Get Concha Margaritifera powder, stir down and slowly joins in the 4mol/l aqueous sulfuric acid of 8 times of amounts, be heated to and boil and kept little 6-7 of boiling hour, at any time add deionized water, filtering residue filters with small amount of thermal water washing twice, merging filtrate is put cold back white, needle-shaped crystals and is separated out, and filters.Under agitation slowly join in the Cornu Bubali hydrolysate, add again after all adding into the solid hydrogen Barium monoxide and transfer pH value to 4, place precipitation fully, filter, be concentrated into 2-3 times of material quantity, put cold, add ethanol under stirring to content 70%, place filtration in 24 hours, reclaim alcohol to nothing alcohol flavor, transfer pH value to 7 with 20% sodium hydroxide, be condensed into extractum.Animal extractum Benexate Hydrochloride preparation: 1, polishing: after beta-schardinger dextrin-added 2 times of deionized waters and grind well, add above-mentioned animal extractum and grind, drying is pulverized, and makes animal extractum clathrate.2, full Heshui solwution method: above-mentioned animal extractum is added in the full Heshui solution of beta-schardinger dextrin-, stirred 90 minutes for 60 ℃ with the magnetic force heating stirrer, put cold putting more than 24 hours in the refrigerator, sucking filtration is collected solids, and drying is pulverized, and makes animal extractum clathrate.3, colloid milling: after beta-schardinger dextrin-added 2 times of deionized waters and grind well, add animal extractum, with the colloid mill 15min that mills, the colloid mill face gap 5 μ m that rub, rotating speed 1500 commentariess on classics/min, drying, pulverizing promptly gets animal extractum clathrate.The present invention compared with prior art, because beta-cyclodextrin inclusion compound cholic acid and animal extractum are adopted in this invention, bitterness in cholic acid, the animal cream and specific peculiar smell are eliminated, make Qingkailing granule with Flos Lonicerae, Radix Isatidis, Fructus Gardeniae spray powder etc. again, make this medicine that the patient is taken, improve this product bioavailability, give full play to the drug effect of QINGKAILING heat-clearing and toxic substances removing, tranquillizing and allaying excitement.
The specific embodiment one: it is raw material with the clathrate that taurine, Hyodeoxycholic Acid and Cornu Bubali, Concha Margaritifera extract animal extractum that the present invention adopts beta-schardinger dextrin-, add Fructus Gardeniae, Radix Isatidis, Flos Lonicerae extract, baicalin and adjuvant, granulate, drying is made Qingkailing granule.The Qingkailing granule preparation: feed intake by formulation 3000g taking-up: filling a prescription is: taurine 13g, Hyodeoxycholic Acid 15g, baicalin 20g, Concha Margaritifera powder 200g, Fructus Gardeniae 100g, Cornu Bubali powder 100g, Radix Isatidis 800g, Flos Lonicerae extract 20g, Icing Sugar 1790g, dextrin 893g, beta-schardinger dextrin-185g.Preparation method: one, cholic acid Benexate Hydrochloride preparation: formula ratio taurine and Hyodeoxycholic Acid are placed 2 times of amount 75%7 alcoholic solutions, transfer pH value to 9 that it is dissolved fully with 20% sodium hydroxide.In the full Heshui solution of above-mentioned cholic acid alcoholic solution adding 105 gram beta-schardinger dextrin-s, stir 90min for 60 ℃ with the magnetic force heating stirrer, to put more than the interior cold 24hr of putting of refrigerator, sucking filtration is collected solids, and drying is pulverized, and makes the cholic acid clathrate.Two, animal extractum Benexate Hydrochloride preparation: water intaking horn powder, stir slowly to be added on down to be heated in 8 times of amount 4mol/l barium hydroxide solutions and boil, stir and keep little boiling 6-7 hour down, at any time add the deionized water filtered while hot, twice of small amount of thermal water washing of filtering residue, filter, merging filtrate is standby; Get Concha Margaritifera powder, stir down and slowly joins in the 4mol/l aqueous sulfuric acid of 8 times of amounts, be heated to and boil and kept little 6-7 of boiling hour, at any time add deionized water, filtering residue filters with small amount of thermal water washing twice, merging filtrate is put cold back white, needle-shaped crystals and is separated out, and filters.Under agitation slowly join in the Cornu Bubali hydrolysate, add an amount of solid hydrogen Barium monoxide after all adding again and transfer pH value to 4, place precipitation fully, filter, be concentrated into 2-3 times of material quantity, put cold, add ethanol under stirring to content 70%, place filtration in 24 hours, reclaim alcohol to nothing alcohol flavor, transfer pH value to 7 with 20% sodium hydroxide, be condensed into extractum.Above-mentioned animal extractum is added in the full Heshui solution of 80 gram beta-schardinger dextrin-s, stir 90min for 60 ℃ with the magnetic force heating stirrer, put more than the interior cold 24hr of putting of refrigerator, sucking filtration is collected solids, and drying is pulverized, and makes animal extractum clathrate.Three, Radix Isatidis, Fructus Gardeniae extract preparation: take by weighing Radix Isatidis decoction pieces and Fructus Gardeniae by formula ratio, after washing, place and extract in the pot, with water extraction twice, merging filtrate, transfer pH value to 7.0 with ammonia, being concentrated into relative density is 1.06-1.07, and spray drying gets spray powder.Spray drying condition: inlet temperature: 150-125 ℃, leaving air temp 85-90 ℃, air mass flow 3000m3/hr.Medicinal liquid flow velocity 30l/hr.Four, baicalin is added appropriate amount of deionized water, transfer pH value to 7.0, it is dissolved fully with 20% sodium hydroxide.Five, with cholic acid Benexate Hydrochloride, animal extractum Benexate Hydrochloride, Flos Lonicerae extract, BANLANBAN, Fructus Gardeniae spray powder, an amount of Icing Sugar and dextrin mixing, add baicalin and become saline solution, fully mixing, granulate in right amount with 75% ethanol, drying, 1000 bags of packing, every bag 3 gram.
The specific embodiment two: essence is opened clever preparation of granules: taurine 13g, Hyodeoxycholic Acid 15g, baicalin 20g, the pink 200g of Concha Margaritifera, Fructus Gardeniae 100g, Cornu Bubali powder 100g, Radix Isatidis 800g, Flos Lonicerae extract 20g, Icing Sugar is an amount of, dextrin is an amount of, beta-schardinger dextrin-167g.Preparation method: one, cholic acid Benexate Hydrochloride preparation: formula ratio taurine and Hyodeoxycholic Acid are placed 2 times of amount 75% alcoholic solution, transfer pH value to 9 that it is dissolved fully with 20% sodium hydroxide.97 gram beta-schardinger dextrin-s are added in the colloid mills, adds 2 times of amount deionized waters and the cholic acid alcoholic solution 15min that mills, the colloid mill face gap 5 μ m that rub, rotating speed 1500 commentariess on classics/min, drying, pulverizing gets the cholic acid Benexate Hydrochloride.Two, animal extractum Benexate Hydrochloride preparation: the water intaking horn powder, stir slowly to be added on down to be heated in 8 times of amount 4mol/l aqueous sulfuric acids and boil and kept little 6-7 of boiling hour, add deionized water at any time, filtered while hot, filtering residue filters with small amount of thermal water washing twice, and merging filtrate is standby; Get Concha Margaritifera powder, stir down and slowly joins in the 4mol/l aqueous sulfuric acid of 8 times of amounts, be heated to and boil and kept little 6-7 of boiling hour, at any time add deionized water, filtering residue filters with small amount of thermal water washing twice, merging filtrate is put cold back white, needle-shaped crystals and is separated out, and filters.Under agitation slowly joining Babalus bubalis L. separates in the liquid, add an amount of solid hydrogen Barium monoxide after all adding again and transfer pH value to 4, place precipitation fully, filter, be concentrated into 2-3 times of material quantity, put cold, add ethanol under stirring to content 70%, place filtration in 24 hours, reclaim alcohol to nothing alcohol flavor, transfer pH value to 7 with 20% sodium hydroxide, being concentrated into relative density is the extractum of 1.36-1.40 (60-65 ℃).Add 2 times of amounts of 70 gram beta-schardinger dextrin-s deionized water in the colloid mill, add the animal extractum 15min that mills again, the colloid mill face gap 5 μ m that rub, rotating speed 1500 commentariess on classics/min, drying is pulverized, and gets animal extractum clathrate.Three, Radix Isatidis, Fructus Gardeniae extract preparation: take by weighing Radix Isatidis decoction pieces and Fructus Gardeniae by formula ratio, with water extraction twice, after washing, place and extract in the pot, merging filtrate is transferred pH value to 7.0 with ammonia, being concentrated into relative density is 1.06-1.07, and spray drying gets spray powder.Spray drying condition: inlet temperature: 120-125 ℃, leaving air temp 85-90 ℃, air mass flow 3000m
3/ hr, medicinal liquid flow velocity 30l/hr.Four, baicalin is added ionized water, transfer pH value to 7.0, it is dissolved fully with 20% sodium hydroxide.Five, with cholic acid Benexate Hydrochloride, animal extractum Benexate Hydrochloride, Flos Lonicerae extract, Radix Isatidis, Fructus Gardeniae spray powder, an amount of Icing Sugar and dextrin mixing, add baicalin and become saline solution, fully mixing, granulate in right amount with 75% ethanol, drying, 1000 bags of packing, every bag 3 gram.
Claims (3)
1, the technology for preparing Qingkailing granule with cyclodextrin inclusion compound cholic acid and animal extractum comprises that Radix Isatidis, Fructus Gardeniae, Flos Lonicerae water propose, and concentrates, and spray drying gets spray powder; Baicalin adds deionized water, transfers pH value to 7.0 with 20% sodium hydroxide, makes its dissolving, it is characterized in that: Hyodeoxycholic Acid, taurine add in the alcoholic solution, transfer pH value to 9 with 20% sodium hydroxide, after the dissolving, make the cholic acid Benexate Hydrochloride fully with beta-schardinger dextrin-; Cornu Bubali, Concha Margaritifera Usta hydrolysate are condensed into extractum, make animal extractum Benexate Hydrochloride with beta-schardinger dextrin-; Spray powder, cholic acid Benexate Hydrochloride, animal extractum Benexate Hydrochloride, Icing Sugar, the dextrin of Flos Lonicerae, Radix Isatidis, Fructus Gardeniae extract are mixed, adding baicalin becomes saline solution fully to mix, make granule with 75% ethanol, drying makes Qingkailing granule.
2, according to claim 1ly prepare the technology of Qingkailing granule, it is characterized in that said cholic acid Benexate Hydrochloride, its molar ratio, cholic acid: beta-schardinger dextrin-=1: 0.8-3.0 with cyclodextrin inclusion compound cholic acid and animal extractum.
3, according to claim 1ly prepare the technology of Qingkailing granule, it is characterized in that said animal extractum Benexate Hydrochloride, its weight ratio that feeds intake, animal extractum: beta-schardinger dextrin-=1: 1-5 with cyclodextrin inclusion compound cholic acid and animal extractum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99112844A CN1101184C (en) | 1999-04-12 | 1999-04-12 | Process for preparing medical particles Qingkailing by wrapping chololic acid and animal extract with cyclodextrin |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99112844A CN1101184C (en) | 1999-04-12 | 1999-04-12 | Process for preparing medical particles Qingkailing by wrapping chololic acid and animal extract with cyclodextrin |
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| Publication Number | Publication Date |
|---|---|
| CN1247078A CN1247078A (en) | 2000-03-15 |
| CN1101184C true CN1101184C (en) | 2003-02-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN99112844A Expired - Lifetime CN1101184C (en) | 1999-04-12 | 1999-04-12 | Process for preparing medical particles Qingkailing by wrapping chololic acid and animal extract with cyclodextrin |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322850C (en) * | 2000-06-02 | 2007-06-27 | 沈阳药科大学 | Nicardipine hydro-chloride powder injection and its preparing method |
| CN102100702B (en) * | 2011-01-20 | 2013-03-06 | 鲁南厚普制药有限公司 | Method for covering stinking smells of animal medicines |
| CN114748432B (en) * | 2022-05-12 | 2023-09-22 | 广州白云山明兴制药有限公司 | Preparation process of traditional Chinese medicine compound granules |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088113A (en) * | 1992-12-08 | 1994-06-22 | 广州明兴制药厂 | A kind of prescription of Chinese herbal medicine oral liquid adjuvant |
| CN1160548A (en) * | 1996-03-29 | 1997-10-01 | 张家口市长城制药厂 | Process for producing Qingkailing powder injection |
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1999
- 1999-04-12 CN CN99112844A patent/CN1101184C/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088113A (en) * | 1992-12-08 | 1994-06-22 | 广州明兴制药厂 | A kind of prescription of Chinese herbal medicine oral liquid adjuvant |
| CN1160548A (en) * | 1996-03-29 | 1997-10-01 | 张家口市长城制药厂 | Process for producing Qingkailing powder injection |
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| CN1247078A (en) | 2000-03-15 |
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Owner name: HARBIN YIZHOU PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: HARBIN YIZHOU PHARMACEUTICAL CO., LTD., YUANDA PHARMACEUTICAL INDUSTRY GROUP |
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| CP01 | Change in the name or title of a patent holder |
Address after: 150076, 24 Pine Road, Daoli District, Heilongjiang, Harbin Patentee after: Harbin Yizhou Pharmaceutical Co., Ltd. of Yuanda Pharmaceutical Group Address before: 150076, 24 Pine Road, Daoli District, Heilongjiang, Harbin Patentee before: Harbin Yizhou Pharmaceutical Co., Ltd., Yuanda Pharmaceutical Industry Group |
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Address after: 150076 Heilongjiang city of Harbin Province Economic and Technological Development Zone auspicious clouds Hanan Industrial Park A District Road No. 1 Patentee after: Harbin Yizhou Pharmaceutical Co., Ltd. of Yuanda Pharmaceutical Group Address before: 150076, 24 Pine Road, Daoli District, Heilongjiang, Harbin Patentee before: Harbin Yizhou Pharmaceutical Co., Ltd. of Yuanda Pharmaceutical Group |
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Granted publication date: 20030212 |