CN110115735A - A kind of preparation method of children heat-cough oral liquid - Google Patents

A kind of preparation method of children heat-cough oral liquid Download PDF

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Publication number
CN110115735A
CN110115735A CN201910551744.5A CN201910551744A CN110115735A CN 110115735 A CN110115735 A CN 110115735A CN 201910551744 A CN201910551744 A CN 201910551744A CN 110115735 A CN110115735 A CN 110115735A
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preparation
alcohol
filtration
taste
corrigent
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彭常春
赵有红
文万江
喻晓霞
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JIANGXI JIMIN KEXIN JINSHUIBAO PHARMACEUTICAL CO Ltd
Jiangxi Jimin Kexin Pharmaceutical Co Ltd
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JIANGXI JIMIN KEXIN JINSHUIBAO PHARMACEUTICAL CO Ltd
Jiangxi Jimin Kexin Pharmaceutical Co Ltd
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Priority to CN201910551744.5A priority Critical patent/CN110115735A/en
Publication of CN110115735A publication Critical patent/CN110115735A/en
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Abstract

The present invention relates to a kind of preparation methods of children heat-cough oral liquid, and the method, steps are as follows: (1) ten taste more than, 10 times of amount water are added to decoct three times, 1 hour every time, collecting decoction, filtration, filtrate decompression are concentrated into 1.10-1.20 (60 DEG C), ethyl alcohol are added to make alcohol content up to 65%, it stirs evenly, stands 24 hours, take supernatant, ethyl alcohol is recycled to no alcohol taste, cream is received, 200 mesh filter clothes are crossed, it is spare；(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose and suitable corrigent is added, stirs evenly, and adds water to adjust total amount to 1000ml, stirs evenly, stand, filtration, encapsulating, sterilizing to get.

Description

A kind of preparation method of children heat-cough oral liquid
Technical field
The invention belongs to pharmaceutical fields, are related to a kind of preparation method for improving children heat-cough oral liquid mouthfeel.
Background technique
Children heat-cough oral liquid is by Herba ephedrae, gypsum, semen armeniacae amarae, Fructus Forsythiae, rheum officinale, Snakegourd Fruit, the root bark of white mulberry, field pennycress, red Colored and ten taste medicinal material of radix glycyrrhizae preparata adds oral liquid made of appropriate excipient, records in the national drug standards YBZ00452012 has clearing heat and freeing lung, the effect of preventing phlegm from forming and stopping coughing.For practising cough caused by syndrome of phlegm-heat obstructing lung, phlegm is yellow or larynx in Gurgling weith sputum, fever, pharyngalgia is thirsty, and stool is dry；Infant bronchitis is shown in above-mentioned patient.Usage and dosage be it is oral, 2-6 years old, once 10ml；7-14 years old, a 20ml, 3 times a day.
Traditional Chinese medicine ingredients are complicated, and taste is how bitter, puckery, salty, sour, pungent, therefore need to often add corrigent to cover and change to a certain extent The bad smell of kind dosage form is particularly suitable for child patient convenient for taking orally.Common corrigent domestic at present has: sweetener, virtue Pastil, mucilage, effervescent agent etc..
The medicinal materials heavy bitter taste such as Herba ephedrae, semen armeniacae amarae in children heat-cough oral liquid, in the prior art using sucrose as strong Taste agent, mouthfeel is bad, and the compliance of children is poor, influences market application.
For this purpose, the present invention studies the prior art, to improve mouthfeel, the compliance of children, this hair are improved It is bright to propose a kind of preparation method of new children heat-cough oral liquid.
Summary of the invention
It is an object of that present invention to provide a kind of preparation methods for improving children heat-cough oral liquid mouthfeel.
Oral solution prepared by the method for the present invention can effectively improve the mouthfeel of this product, convenient for for oral administration, especially by The welcome of child patient.
For this purpose, the present invention provides a kind of preparation method of children heat-cough oral liquid, the children heat-cough oral liquid be by with The Chinese medicine material medicine of lower weight proportion is prepared: Herba ephedrae 60g gypsum 200g semen armeniacae amarae 120g Fructus Forsythiae 200g rheum officinale 40g melon Beach wormwood 120g root bark of white mulberry 120g field pennycress 200g safflower 120g radix glycyrrhizae preparata 60g, the preparation method, steps are as follows:
(1) ten taste more than adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose and suitable corrigent is added, stirs evenly, and adds water adjustment total Amount is stirred evenly to 1000ml, is stood, filtration, encapsulating, sterilizing to get.
Wherein, the corrigent is selected from: Sucralose, aspartame, stevioside, neotame, one kind of refrigerant alcohol, cocoa tincture Or it is several.
Wherein, the corrigent, when the Sucralose of addition, dosage 0.3-0.5g/L.
Wherein, the corrigent, when aspartame is added, dosage 2.0-5.0g/L.
Wherein, the corrigent, when refrigerant alcohol is added, dosage 0.2-0.3g/L.
Wherein, the corrigent, when cocoa tincture is added, dosage 1.0-3.0g/L.
Wherein, the corrigent is the mixture of Sucralose and cocoa tincture, the two ratio are as follows: 0.1-0.5:1 is added Dosage is 1.3-3.5g/L.
Wherein, the corrigent is the mixture of aspartame and refrigerant alcohol, the two ratio are as follows: 10-25:1, addition agent Amount is 2.2-5.3g/L.
Preferably, preparation method of the invention, comprising the following steps:
(1) ten taste more than adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose and suitable corrigent is added, stirs evenly, and adds water adjustment total Amount is stirred evenly to 1000ml, is stood, filtration, encapsulating, sterilizing to get.
It is further preferred that preparation method of the invention, comprising the following steps:
(1) ten taste more than adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose, Sucralose and cocoa tincture or aspartame and clear is added Cool alcohol stirs evenly, and adds water to adjust total amount to 1000ml, stirs evenly, stands, filtration, encapsulating, sterilizing to get.
The preparation method is that obtained by many experiments screening, wherein the preparation of extracting method, screening process It is as follows:
The selection of decocting time and number: respectively to 8 times, 10 times, 12 times of amount of water and decoction 2 times, 3 times, 1 is small every time When, it is prepared as described above method and receives cream, be to investigate target with total ephedrine rate of transform, as a result with 3 10 times of amount of water, decoction transfers Rate is best；
The selection of alcohol content: being prepared as described above the worth clear cream of method, be separately added into ethyl alcohol make alcohol content be 60%, 65%, 70%, 24 as a child observe alcohol precipitation effect, and 65%, 70% alcohol precipitation effect is preferable, comprehensively consider ethyl alcohol consumption, select 65% alcohol content.
Finally obtained clear cream the preparation method is as follows:
Above ten taste adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
In addition, the present invention takes volunteer's mouth to taste and appraise point-score, 10 health aspirations also to the preferred of variety classes corrigent Person while kind this product solution, by recording its bitter taste triggered time (taste and how long occur bitter taste afterwards), bitter taste journey 4 degree, smell, level of sweetness sense of taste indexs evaluate mouthfeel, and grade form is detailed in following table:
Table 1: mouth feel score standard scale
Experiment: the selection of corrigent
1, prepared by oral solution
Qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose and suitable corrigent is added, stirs evenly, and adds water adjustment total amount extremely 1000ml is stirred evenly, stand, filtration, encapsulating, sterilizing to get.
2, the preparation of existing prescription oral solution and mouthfeel evaluation: qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose is added, stirs It is even, add water to adjust total amount to 1000ml, stir evenly, stand, filtration, encapsulating, sterilizing to get；Mouthfeel evaluation result is as follows:
Table 2: it is not added with the oral solution mouthfeel evaluation of corrigent preparation
3, single corrigent mouthfeel evaluation
Qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose and suitable corrigent is added, stirs evenly, and adds water adjustment total amount extremely 1000ml is stirred evenly, stand, filtration, encapsulating, sterilizing to get.
The additive amount of corrigent is as follows:
Sample Corrigent type and dosage
1-1 Sucralose: 0.3-0.5g/L
1-2 Aspartame: 2.0-5.0g/L
1-3 Stevioside: 1-2g/L
1-4 Neotame: 0.2-0.5g/L
1-5 Refrigerant alcohol: 0.2-0.3g/L
1-6 Cocoa tincture: 1.0-3.0g/L
10 volunteers are counted to carry out statistics to sweet taste, bitter taste, smell and the result in triggered time to acquire overall score equal Value simultaneously evaluates mouthfeel, is as follows:
Sample Corrigent type and dosage Overall score Mouthfeel
1-1 Sucralose: 0.3-0.5g/L 6.2 Sweet taste is moderate, bitter taste is light, odorous
1-2 Aspartame: 2.0-5.0g/L 5.7 Sweet taste is moderate, bitter taste is light, odorous
1-3 Stevioside: 1-2g/L 4.0 Sweet taste is light, bitter, odorous
1-4 Neotame: 0.2-0.5g/L 3.4 Sweet taste is light, bitter, odorous
1-5 Refrigerant alcohol: 0.2-0.3g/L 3.2 Sweet taste is without bitter, refrigerant sense
1-6 Cocoa tincture: 1.0-3.0g/L 2.9 Sweet taste is without bitter, aromatic
Interpretation of result:
As seen from the above table, above-mentioned each corrigent, which is individually added into, can improve mouthfeel, with Sucralose and aspartame flavoring Effect is preferable, but general effect is not good enough, and lower step continuess to mix the screening of corrigent.
4, mixing corrigent mouthfeel evaluation
In conjunction with single corrigent as a result, the preferable Sucralose of selection flavoring effect, aspartame and refrigerant alcohol, cocoa Tincture is screened；
Qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose and suitable two kinds of corrigents is added, stirs evenly, and adds water adjustment total Amount is stirred evenly to 1000ml, is stood, filtration, encapsulating, sterilizing to get.
The additive amount of corrigent is as follows:
Sample Corrigent type and dosage
2-1 Sucralose: the refrigerant alcohol of 0.3-0.5g/L+: 0.2-0.3g/L
2-2 Sucralose: 0.3-0.5g/L+ cocoa tincture: 1.0-3.0g/L
2-3 Aspartame: the refrigerant alcohol of 2.0-5.0g/L+: 0.2-0.3g/L
2-4 Aspartame: 2.0-5.0g/L+ cocoa tincture: 1.0-3.0g/L
10 volunteers are counted to carry out statistics to sweet taste, bitter taste, smell and the result in triggered time to acquire overall score equal Value simultaneously evaluates mouthfeel, is as follows:
Interpretation of result:
As seen from the above table, above-mentioned each corrigent mixing, which is added, can significantly improve mouthfeel, with sample 2-2,2-3 flavoring effect Preferably.Wherein, preferred plan are as follows: qinghuo reagent adds water, refrigerates, and filtration is boiled, be added sucrose and corrigent (Sucralose: 0.3-0.5g, cocoa tincture: 1.0-3.0g or aspartame: 2.0-5.0g, refrigerant alcohol: 0.2-0.3g), it stirs evenly, adds water adjustment total Amount is stirred evenly to 1000ml, is stood, filtration, encapsulating, sterilizing to get.
Therefore, by screening of the invention, it is obtained most preferred the preparation method is as follows:
(1) ten taste more than adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose and corrigent (Sucralose: 0.3-0.5g, cocoa is added Tincture: 1.0-3.0g or aspartame: 2.0-5.0g, refrigerant alcohol: 0.2-0.3g), it stirs evenly, adds water adjustment total amount to 1000ml, stir It is even, stand, filtration, encapsulating, sterilizing to get.
Specific embodiment
By following specific embodiments, the present invention is further illustrated, but not as limitation of the invention.
Embodiment 1, oral solution of the invention
Prescription:
Preparation process:
(1) ten taste more than adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and addition sucrose, Sucralose stir evenly, and adds water adjustment total amount extremely 1000ml is stirred evenly, stand, filtration, encapsulating, sterilizing to get.
Embodiment 2, oral solution of the invention
Prescription:
Preparation process:
(1) ten taste more than adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and addition sucrose, aspartame stir evenly, and adds water adjustment total amount extremely 1000ml is stirred evenly, stand, filtration, encapsulating, sterilizing to get.
Embodiment 3, oral solution of the invention
Prescription:
Preparation process:
(1) ten taste more than adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and addition sucrose, cocoa tincture stir evenly, and adds water adjustment total amount extremely 1000ml is stirred evenly, stand, filtration, encapsulating, sterilizing to get.
Embodiment 4, oral solution of the invention
Prescription:
Preparation process:
(1) ten taste more than adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and addition sucrose, refrigerant alcohol stir evenly, and adds water adjustment total amount extremely 1000ml is stirred evenly, stand, filtration, encapsulating, sterilizing to get.
Embodiment 5, oral solution of the invention
Prescription:
Preparation process:
(1) ten taste more than adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose, Sucralose and cocoa tincture is added and stirs evenly, water is added to adjust Total amount is stirred evenly to 1000ml, is stood, filtration, encapsulating, sterilizing to get.
Embodiment 6, oral solution of the invention
Prescription:
Preparation process:
(1) ten taste more than adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose, aspartame and refrigerant alcohol is added and stirs evenly, water is added to adjust Total amount is stirred evenly to 1000ml, is stood, filtration, encapsulating, sterilizing to get.
Embodiment 7, oral solution of the invention
Prescription:
Preparation process:
(1) ten taste more than adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose, aspartame and cocoa tincture is added and stirs evenly, water is added to adjust Total amount is stirred evenly to 1000ml, is stood, filtration, encapsulating, sterilizing to get.
Embodiment 8, oral solution of the invention
Prescription:
Preparation process:
(1) ten taste more than adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose, Sucralose and refrigerant alcohol is added and stirs evenly, water is added to adjust Total amount is stirred evenly to 1000ml, is stood, filtration, encapsulating, sterilizing to get.

Claims (8)

1. a kind of preparation method of children heat-cough oral liquid, the children heat-cough oral liquid is former by the Chinese medicine of following weight proportion Material medicine is prepared: Herba ephedrae 60g gypsum 200g semen armeniacae amarae 120g Fructus Forsythiae 200g rheum officinale 40g Snakegourd Fruit 120g root bark of white mulberry 120g loses Sauce grass 200g safflower 120g radix glycyrrhizae preparata 60g,
It is characterized in that, the preparation method, steps are as follows:
(1) ten taste more than adds 10 times of amount water to decoct three times, and 1 hour every time, collecting decoction filtered, and filtrate decompression is concentrated into 1.10-1.20 (60 DEG C), adds ethyl alcohol to make alcohol content up to 65%, stirs evenly, and stands 24 hours, takes supernatant, recycling ethyl alcohol to no alcohol Taste receives cream, crosses 200 mesh filter clothes, spare；
(2) qinghuo reagent adds water, refrigerates, and filtration is boiled, and sucrose and suitable corrigent is added, stirs evenly, and adds water adjustment total amount extremely 1000ml is stirred evenly, stand, filtration, encapsulating, sterilizing to get.
2. preparation method according to claim 1, which is characterized in that corrigent is selected from: Sucralose, aspartame, sweet tea Synanthrin, neotame, the one or more of refrigerant alcohol, cocoa tincture.
3. preparation method according to claim 1, which is characterized in that the Sucralose of addition is 0.3-0.5g/L.
4. preparation method according to claim 1, which is characterized in that addition aspartame is 2.0-5.0g/L.
5. preparation method according to claim 1, which is characterized in that it is 0.2-0.3g/L that refrigerant alcohol, which is added,.
6. preparation method according to claim 1, which is characterized in that addition cocoa tincture is 1.0-3.0g/L.
7. preparation method according to claim 1, which is characterized in that the corrigent of addition is Sucralose and cocoa tincture.
8. preparation method according to claim 1, which is characterized in that the corrigent of addition is aspartame and refrigerant alcohol.
CN201910551744.5A 2019-06-25 2019-06-25 A kind of preparation method of children heat-cough oral liquid Pending CN110115735A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110433225A (en) * 2019-09-12 2019-11-12 江西济民可信金水宝制药有限公司 A kind of preparation method of clearing heat and freeing lung children heat-cough oral liquid

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102078403A (en) * 2009-11-30 2011-06-01 江西济民可信药业有限公司 Detection method of Chinese traditional medicine preparation of oral liquid for treating infant cough with lung heat
CN102188575A (en) * 2010-03-03 2011-09-21 鲁南厚普制药有限公司 Oral liquid preparation for treating infantile indigestion with food retention and cough and preparation method thereof
CN108310124A (en) * 2018-03-21 2018-07-24 江西济民可信药业有限公司 A kind of hot children heat-cough oral liquid of clearing lung-heat and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102078403A (en) * 2009-11-30 2011-06-01 江西济民可信药业有限公司 Detection method of Chinese traditional medicine preparation of oral liquid for treating infant cough with lung heat
CN102188575A (en) * 2010-03-03 2011-09-21 鲁南厚普制药有限公司 Oral liquid preparation for treating infantile indigestion with food retention and cough and preparation method thereof
CN108310124A (en) * 2018-03-21 2018-07-24 江西济民可信药业有限公司 A kind of hot children heat-cough oral liquid of clearing lung-heat and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110433225A (en) * 2019-09-12 2019-11-12 江西济民可信金水宝制药有限公司 A kind of preparation method of clearing heat and freeing lung children heat-cough oral liquid

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