CN110114075B - 含有二硫化物的细胞穿透肽及其制备和使用方法 - Google Patents

含有二硫化物的细胞穿透肽及其制备和使用方法 Download PDF

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Publication number
CN110114075B
CN110114075B CN201780069098.8A CN201780069098A CN110114075B CN 110114075 B CN110114075 B CN 110114075B CN 201780069098 A CN201780069098 A CN 201780069098A CN 110114075 B CN110114075 B CN 110114075B
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peptide
arginine
amino acids
bicyclic
independently
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Chinese (zh)
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CN110114075A (zh
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裴德华
钱自清
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Ohio State Innovation Foundation
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Ohio State Innovation Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201780069098.8A 2016-11-09 2017-11-09 含有二硫化物的细胞穿透肽及其制备和使用方法 Active CN110114075B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202410024308.3A CN117866042A (zh) 2016-11-09 2017-11-09 含有二硫化物的细胞穿透肽及其制备和使用方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662419781P 2016-11-09 2016-11-09
US62/419,781 2016-11-09
US201662425550P 2016-11-22 2016-11-22
US62/425,550 2016-11-22
US201662438141P 2016-12-22 2016-12-22
US62/438,141 2016-12-22
PCT/US2017/060881 WO2018089648A2 (en) 2016-11-09 2017-11-09 Di-sulfide containing cell penetrating peptides and methods of making and using thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202410024308.3A Division CN117866042A (zh) 2016-11-09 2017-11-09 含有二硫化物的细胞穿透肽及其制备和使用方法

Publications (2)

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CN110114075A CN110114075A (zh) 2019-08-09
CN110114075B true CN110114075B (zh) 2024-01-12

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CN201780069098.8A Active CN110114075B (zh) 2016-11-09 2017-11-09 含有二硫化物的细胞穿透肽及其制备和使用方法
CN202410024308.3A Pending CN117866042A (zh) 2016-11-09 2017-11-09 含有二硫化物的细胞穿透肽及其制备和使用方法

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US (2) US11351222B2 (enExample)
EP (1) EP3538125B1 (enExample)
JP (2) JP7175887B2 (enExample)
CN (2) CN110114075B (enExample)
CA (1) CA3043464A1 (enExample)
TW (1) TWI781963B (enExample)
WO (1) WO2018089648A2 (enExample)

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CA3087881A1 (en) 2017-01-17 2018-07-26 Michael David FORREST Therapeutic inhibitors of the reverse mode of atp synthase
CA3099077A1 (en) 2017-07-13 2019-01-17 Michael David FORREST Therapeutic modulators of the reverse mode of atp synthase
US11339192B2 (en) 2017-10-04 2022-05-24 Ohio State Innovation Foundation Bicyclic peptidyl inhibitors
CN111447941B (zh) 2017-10-27 2023-10-31 俄亥俄州国家创新基金会 用于细胞内递送装订肽的多肽缀合物
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CN110734474B (zh) * 2019-11-29 2021-10-19 中山大学 一种抗菌肽的筛选方法及其应用
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WO2022065173A1 (ja) * 2020-09-23 2022-03-31 株式会社カネカ 細胞膜透過性分子及びその利用、並びに細胞膜透過性分子の細胞膜透過性の向上方法
WO2022065172A1 (ja) * 2020-09-23 2022-03-31 株式会社カネカ 細胞膜透過性分子及びその利用、並びに細胞膜透過性分子の細胞膜透過性の向上方法
US20250325469A1 (en) 2021-01-24 2025-10-23 Michael David FORREST Inhibitors of atp synthase - cosmetic and therapeutic uses
EP4294820A4 (en) * 2021-02-22 2025-04-09 Ohio State Innovation Foundation Cyclic cell-penetrating peptides with three or more hydrophobic residues
WO2022271810A2 (en) * 2021-06-22 2022-12-29 Ohio State Innovation Foundation Bicyclic peptidyl pan-ras inhibitors
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Also Published As

Publication number Publication date
JP2020502051A (ja) 2020-01-23
WO2018089648A3 (en) 2018-06-21
US20190282654A1 (en) 2019-09-19
EP3538125B1 (en) 2026-07-15
CA3043464A1 (en) 2018-05-17
EP3538125A2 (en) 2019-09-18
CN117866042A (zh) 2024-04-12
US11351222B2 (en) 2022-06-07
JP7175887B2 (ja) 2022-11-21
US20220160819A1 (en) 2022-05-26
TW201823266A (zh) 2018-07-01
EP3538125A4 (en) 2020-10-07
TWI781963B (zh) 2022-11-01
CN110114075A (zh) 2019-08-09
WO2018089648A2 (en) 2018-05-17
JP7490735B2 (ja) 2024-05-27
JP2023025022A (ja) 2023-02-21
US11878046B2 (en) 2024-01-23

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