CN110114072A - 聚合物纳米颗粒 - Google Patents

聚合物纳米颗粒 Download PDF

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Publication number
CN110114072A
CN110114072A CN201780080722.4A CN201780080722A CN110114072A CN 110114072 A CN110114072 A CN 110114072A CN 201780080722 A CN201780080722 A CN 201780080722A CN 110114072 A CN110114072 A CN 110114072A
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CN
China
Prior art keywords
tnf
seq
peg
nanoparticles
peptide
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Pending
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CN201780080722.4A
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English (en)
Chinese (zh)
Inventor
S·哈班达
V·舒克拉
D·库夫
H·思恩赫
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Namipert Egan Co
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Namipert Egan Co
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Publication of CN110114072A publication Critical patent/CN110114072A/zh
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    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]

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