CN110099697B - 用于消融造血干细胞的抗体药物缀合物 - Google Patents

用于消融造血干细胞的抗体药物缀合物 Download PDF

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CN110099697B
CN110099697B CN201780079504.9A CN201780079504A CN110099697B CN 110099697 B CN110099697 B CN 110099697B CN 201780079504 A CN201780079504 A CN 201780079504A CN 110099697 B CN110099697 B CN 110099697B
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seq
fab
light chain
antibody
conjugate
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CN110099697A (zh
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B·温
A·E·博伊塔诺
M·比尔热
S·E·塞利蒂
M·P·库克
C·芬纳
B·H·盖尔斯坦格尔
陈允豪
S·T·李-赫夫利希
H·T·彭
S·H·施莱尔
K·蒂索
宇野哲郎
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Novartis AG
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Novartis AG
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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CN201780079504.9A 2016-12-21 2017-12-19 用于消融造血干细胞的抗体药物缀合物 Active CN110099697B (zh)

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US201662437622P 2016-12-21 2016-12-21
US62/437,622 2016-12-21
US201762520854P 2017-06-16 2017-06-16
US62/520,854 2017-06-16
PCT/IB2017/058159 WO2018116178A1 (en) 2016-12-21 2017-12-19 Antibody drug conjugates for ablating hematopoietic stem cells

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UY38265A (es) * 2018-06-20 2020-01-31 Novartis Ag Conjugados anticuerpo droga para ablación de células madre hematopoyéticas
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AU2019366960A1 (en) * 2018-10-23 2021-05-27 Vor Biopharma, Inc. Fc silenced antibody drug conjugates (ADCs) and uses thereof
US20230053449A1 (en) * 2018-10-31 2023-02-23 Novartis Ag Dc-sign antibody drug conjugates
PL3817773T3 (pl) 2018-11-26 2024-10-28 Forty Seven, Inc. Humanizowane przeciwciała przeciwko c-kit
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