CN110074752A - A kind of cone cell imaging device - Google Patents
A kind of cone cell imaging device Download PDFInfo
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- CN110074752A CN110074752A CN201910325949.1A CN201910325949A CN110074752A CN 110074752 A CN110074752 A CN 110074752A CN 201910325949 A CN201910325949 A CN 201910325949A CN 110074752 A CN110074752 A CN 110074752A
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- 238000003384 imaging method Methods 0.000 title claims abstract description 50
- 230000003287 optical effect Effects 0.000 claims abstract description 29
- 230000003044 adaptive effect Effects 0.000 claims abstract description 28
- 230000001427 coherent effect Effects 0.000 claims abstract description 18
- 238000012545 processing Methods 0.000 claims abstract description 17
- 230000010287 polarization Effects 0.000 claims description 6
- 239000013307 optical fiber Substances 0.000 claims description 5
- 238000001228 spectrum Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 12
- 239000000835 fiber Substances 0.000 description 9
- 230000006872 improvement Effects 0.000 description 8
- 210000001525 retina Anatomy 0.000 description 8
- 230000004075 alteration Effects 0.000 description 7
- 210000005036 nerve Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 230000002207 retinal effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000012014 optical coherence tomography Methods 0.000 description 3
- 230000000644 propagated effect Effects 0.000 description 3
- 102000004330 Rhodopsin Human genes 0.000 description 2
- 108090000820 Rhodopsin Proteins 0.000 description 2
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- 201000007254 color blindness Diseases 0.000 description 2
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- 208000036693 Color-vision disease Diseases 0.000 description 1
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- 238000012937 correction Methods 0.000 description 1
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- KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 description 1
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
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Abstract
A kind of cone cell imaging device provided by the invention, including adaptive optics scanning laser ophthalmoscope (AOSLO), optical coherent chromatographic imaging (OCT) and imaging processing device, to be carried out by optical coherent chromatographic imaging (OCT) cone cell into eyeground light beam carry out processing returns to rear, again and by carrying out interference processing after the beam treatment of adaptive optics scanning laser ophthalmoscope (AOSLO), and the interference signal of processing is sent to imaging processing device and carries out generating high accuracy three-dimensional image, it can be realized the activity condition for observing the cone cell on eyeground.
Description
Technical field
The present invention relates generally to a kind of imaging device, a kind of particularly cone cell imaging device.
Background technique
Application of the adaptive optics (AO) in ophthalmology is can adaptively correcting light by wavefront receptor-wavefront controller
The various aberrations of system, greatly improve system lateral resolution.Human eye itself is an optical system, and optical system is in measurement people
Often there are various aberrations during eye, seriously affects image quality.Introducing adaptive optical technique in optical system can
Solve the problems, such as this.This patent is by combining adaptive optical scanner laser ophthalmoscope (AOSLO) and optical coherent chromatographic imaging skill
Art (OCT) combines, and resolution ratio of the system on two-dimensional space is greatly improved, and observes view caused by the grade activity of its cone cell
Nethike embrane layer activity condition, can assess cone cell mobility.
Because cone cell can receive light stimulus, and convert light energy into nerve impulse, having included photoactive substance, (visual purple is blue
Matter).Under light stimulus, a series of photochemical transformations can occur for photoactive substance and current potential changes, and make cone cell that nerve occur
Impulsion.The present invention can provide nerve impulse by the cone cell layer on the light stimulation based retinal of light source broadband, observation cone cell
When to the motion conditions of each layer of retina.Its multidate information is extracted from the retina three-dimensional image information collected, is analyzed
The liveness of cell, to reach assessment Retinal impression process.
Visual cell is the optic nerve of retina, and cone cell is the pith of visual cell, is distributed mainly on center
Concave region, critical function are to distinguish between colors, and there are three types of the cone cells especially sensitive to different wave length in retina, a kind of
Absorption peak is outside 420nm, and for one kind outside 531nm, one kind corresponds essentially to the wavelength of bluish-green red trichromatism light outside 558nm.It is red
Deuteranopia morbidity is closely bound up with cone cell activity, observes the activity condition of cone cell as a result, for colour blindness disease research
Important in inhibiting.
Close the relevant technologies have with the present invention: a kind of " laser diffraction line scanning confocal inspection eye based on adaptive optics
Mirror system " (CN201210523966.4), " scanned optical image acquisition equipment and its controlling party with adaptive optics system
Method " adaptive optics laser ophthalmoscope principle mentioned in (CN201080016622.3), but it is different from above system application,
This patent is combined with Optical Coherence Tomography Imaging Technology, it is intended to which each layer of retina caused by observation is stimulated by cone cell is living
It is dynamic, compensate for the blank in cone cell activity detection field.
Summary of the invention
In order to overcome the drawbacks of the prior art, the present invention provides a kind of cone cell imaging device, it is clear to may be implemented
Ground observes the activity condition of the cone cell on eyeground.
In order to realize the above technical effect, the present invention adopts the following technical scheme:
A kind of cone cell imaging device, described device include adaptive optics scanning laser ophthalmoscope (AOSLO), optics
Coherence chromatographic imaging (OCT) and imaging processing device, wherein adaptive optics scanning laser ophthalmoscope (AOSLO) includes the first light
Source module, Wavefront detecting module, Corrective control module, scan module；Optical coherent chromatographic imaging (OCT) includes second light source mould
Block, intervention module and interference signal receiving module.
A kind of improvement as above-mentioned technical proposal, wherein adaptive optics scanning laser ophthalmoscope (AOSLO) further include
Beam splitter (BS), condenser lens (FL) and photomultiplier tube (PMT).
A kind of improvement as above-mentioned technical proposal, wherein adaptive optics scanning laser ophthalmoscope (AOSLO) further include
4f system and photomultiplier tube (PMT).
A kind of improvement as above-mentioned technical proposal, wherein light source module includes laser and fiber coupler.
A kind of improvement as above-mentioned technical proposal, wherein Wavefront detecting module includes Wavefront sensor.
A kind of improvement as above-mentioned technical proposal, wherein Corrective control module includes distorting lens, and scan module includes sweeping
Galvanometer is retouched, wherein scanning galvanometer includes quick transversal scanning galvanometer and longitudinal scanning galvanometer at a slow speed.
A kind of improvement as above-mentioned technical proposal, wherein second light source module is identical as first light source module or not phase
Together.
A kind of improvement as above-mentioned technical proposal, wherein intervention module includes Polarization Controller and collimating mirror.
A kind of improvement as above-mentioned technical proposal, wherein interference signal receiving module includes that spectrometer module and balance are visited
Device is surveyed, spectrometer module includes grating, condenser lens and camera, and wherein grating is diffraction grating, and camera is linear camera, imaging
Processing unit includes computer.
Technical effect:
A kind of cone cell imaging device provided by the invention, including adaptive optics scanning laser ophthalmoscope (AOSLO),
Optical coherent chromatographic imaging (OCT) and imaging processing device will carry out the view into eyeground by optical coherent chromatographic imaging (OCT)
The light beam for boring cell is carried out processing returns to rear, then with the beam treatment that passes through adaptive optics scanning laser ophthalmoscope (AOSLO)
After carry out interference processing, and the interference signal of processing is sent to imaging processing device and carries out generating high accuracy three-dimensional image, energy
It is enough to realize the activity condition for clearly observing the cone cell on eyeground.
Detailed description of the invention
It will be obtained more fully from the detailed description of the embodiment below with reference to attached drawing with other advantages and features below
Understand, attached drawing must be considered in illustrative and non-limiting mode, in which:
Fig. 1 is the structure chart according to a kind of cone cell imaging device of the embodiment of the present invention；
Fig. 2 is a kind of cone cell imaging device schematic diagram according to another embodiment of the invention.
Specific embodiment
It is carried out below with reference to technical effect of the embodiment and attached drawing to design of the invention, specific structure and generation clear
Chu, complete description, to be completely understood by the purpose of the present invention, scheme and effect.It should be noted that the case where not conflicting
Under, the features in the embodiments and the embodiments of the present application can be combined with each other.
It should be noted that unless otherwise specified, when a certain feature referred to as " fixation ", " connection " are in another feature,
It can directly fix, be connected to another feature, and can also fix, be connected to another feature indirectly.In addition, this
The descriptions such as upper and lower, left and right used in invention are only the mutual alignment pass relative to each component part of the present invention in attached drawing
For system.In the present invention and the "an" of singular used in the attached claims, " described " and "the" also purport
It is including most forms, unless the context clearly indicates other meaning.
In addition, unless otherwise defined, the technology of all technical and scientific terms used herein and the art
The normally understood meaning of personnel is identical.Term used in the description is intended merely to description specific embodiment herein, without
It is to limit the present invention.Term as used herein "and/or" includes the arbitrary of one or more relevant listed items
Combination.
It will be appreciated that though various elements, but this may be described using term first, second, third, etc. in the disclosure
A little elements should not necessarily be limited by these terms.These terms are only used to for same type of element being distinguished from each other out.For example, not departing from
In the case where disclosure range, first element can also be referred to as second element, and similarly, second element can also be referred to as
One element.Depending on context, word as used in this " if " can be construed to " ... when " or " when ...
When ".
Fig. 1 is the structure chart according to a kind of system of the embodiment of the present invention.As shown in Figure 1, it is provided by the invention, it is described
Device includes adaptive optics scanning laser ophthalmoscope AOSLO, optical coherent chromatographic imaging OCT and processing unit, wherein adaptive
Answering optical scanner laser ophthalmoscope AOSLO includes first light source module, Wavefront detecting module, Corrective control module and scanning mould
Block；Optical coherent chromatographic imaging OCT includes second light source module, intervention module and interference signal receiving module.
In one embodiment of the invention, it is preferable that first light source module includes laser and fiber coupler,
In, laser is for being continually transmitted light source, and laser can be superradiance semiconductor laser, and laser is also possible to super company
Continuous light source SCL.
In one embodiment of the invention, it is preferable that Wavefront detecting module includes Wavefront sensor WVS, for obtaining
Wave front aberration.
In one embodiment of the invention, it is preferable that wherein Corrective control module includes distorting lens DM, can be by changing
Become the mirror angle of distorting lens to control the angle of light.
In one embodiment of the invention, it is preferable that wherein scan module includes scanning galvanometer, wherein scanning galvanometer packet
It includes quick transversal scanning galvanometer FS and longitudinal scanning galvanometer SS is for scanning eyeground at a slow speed, quick transversal scanning galvanometer FS and at a slow speed
Light is converged at into cone cell layer in eyeground nethike embrane layer after longitudinal scanning galvanometer SS array sweeping.
In one embodiment of the invention, it is preferable that wherein second light source module is identical as first light source module.
In another embodiment of the present invention, it is preferable that wherein second light source module and first light source module be not identical.
In one embodiment of the invention, it is preferable that wherein intervention module includes Polarization Controller PC, collimating mirror CL.
In one embodiment of the invention, it is preferable that wherein interference signal receiving module include grating, condenser lens and
Camera, wherein grating is diffraction grating, and camera is linear camera.
In one embodiment of the invention, it is preferable that wherein imaging processing device includes computer.
As shown in Figure 1, specific optical path trend is as follows: the broadband light that Supercontinuum source SCL is issued initially enters optical fiber coupling
It is divided into two-beam after clutch FOC, light beam enters adaptive optics scanning laser ophthalmoscope AOSLO and (also referred to as refers to
Arm), the second beam light enters optical coherent chromatographic imaging OCT.In detail, light beam is passed through by third Polarization Controller PC3
First collimating mirror CL1 carries out the first light beam of collimation, is then focused processing using the second condenser lens FL2, light is passed
It send to plane mirror M, then plane mirror M will penetrate the first light beam come according to principle of reflection, by the first light beam backtracking to optical fiber
Coupler FOC.
Second beam light is handled by the first Polarization Controller PC1, is injected by dichronic mirror DRM and the first beam splitter BS
First surface mirror CM1 and the second curved mirror CM2, first surface mirror CM1 and the second curved mirror CM2 form the first confocal system,
For eliminating system stray light, distorting lens DM is injected by processed second light beam of confocal system again, can be changed by control
The mirror angle of distorting lens DM adjusts the incident angle of the second light beam, and by second by third curved mirror CM3 and
Second confocal system of the 4th curved mirror CM4 composition, then via quick transversal scanning galvanometer FS and at a slow speed, longitudinal scanning shakes
Mirror SS combines to handle the second light beam, wherein being additionally provided between quick transversal scanning galvanometer FS and at a slow speed longitudinal scanning galvanometer SS
5th curved mirror CM5 and the 6th curved mirror CM6 transmits the second light beam using the 7th curved mirror CM7 and the 8th curved mirror CM8
To the first plane mirror FM1, cone cell is then sent to by the second plane mirror FM2.Come from the return of the cone cell on eyeground
Second light beam backtracking to the first beam splitter BS1 injects microlens array LEA and Wavefront sensor through the second beam splitter BS2
WVS obtains wave front aberration through Wavefront sensor WVS, and returns to control distorting lens correction wave front aberration, is then return to optical fiber coupling
Clutch FOC.
So far, from adaptive optics scanning laser ophthalmoscope AOSLO return the first light beam with from optical coherence tomography at
As OCT return the second light beam interfered, by the second Polarization Controller PC2 handle after, be transmitted to the second collimating mirror CL2 into
Row collimation, then it is sent to the first condenser lens FL1 after handling via grating G, it is resent to camera, after camera receives data,
Computer installation is sent to via camera again to carry out being processed into cone cell three-dimensional imaging.
It, can be by the retina on eyeground by the combination of optical coherent chromatographic imaging OCT and optical coherent chromatographic imaging OCT
The motion conditions of each layer pass through the optical signal of adaptively correcting human eye aberration, and high-precision eye image is presented.
Because cone cell can receive light stimulus, and convert light energy into nerve impulse, having included photoactive substance, (visual purple is blue
Matter).Under light stimulus, a series of photochemical transformations can occur for photoactive substance and current potential changes, and cone cell is made to provide nerve
Impulsion.The present invention can provide nerve impulse by the cone cell layer on the light stimulation based retinal of light source broadband, observation cone cell
When to the motion conditions of each layer of retina.Its multidate information is extracted from the retina three-dimensional image information collected, is analyzed
The liveness of cell, to reach assessment Retinal impression process.
In addition, adaptive inertia weight is combined with laser ophthalmoscope.Laser ophthalmoscope system includes light source SCL, collimation lens
CL3, beam splitter BS, condenser lens FL3 and photomultiplier tube PMT.It is to have already passed through certainly since photomultiplier tube PMT is received
The optical signal of the corrected human eye aberration of optical path is adapted to, therefore, photomultiplier tube PMT doubles processed light letter in which can dramatically
Number, so that high-precision eye image can be presented again after computer is handled.
Fig. 2 is the schematic diagram according to the cone cell imaging device of another embodiment of the present invention.The cone cell at
As device includes adaptive optics scanning laser ophthalmoscope AOSLO and optical coherent chromatographic imaging OCT.Light beam to human eye is divided into
Two-way, first via light beam come from adaptive optics scanning laser ophthalmoscope AOSLO, the second road light beam from optical coherence tomography at
As OCT.
Adaptive optics scanning laser ophthalmoscope AOSLO includes light source, attenuator, spectroscope, curved mirror, galvanometer, 4f system
System and photomultiplier tube.Optical coherent chromatographic imaging OCT include scanning light source, fiber coupler, balanced detector, collimator and
Grating.In adaptive optics scanning laser ophthalmoscope AOSLO module, first via light beam is from light source+attenuator, along light splitting
Mirror, curved mirror, curved mirror, galvanometer, curved mirror, curved mirror, galvanometer are bidirectionally propagated, and are bidirectionally sent to dichroic
Mirror wherein separating a light beam by spectroscope, and is uniaxially successively propagated to 4f Systematic Communication, photomultiplier tube.
In optical coherent chromatographic imaging OCT module, beam propagation is launched to fiber coupler, simultaneously by swept light source
Two-way light beam is divided by fiber coupler, first via light beam blazes abroad from optical coherent chromatographic imaging OCT module, successively propagates
To collimator, galvanometer, galvanometer, 4f system, dichroscope；Second road light beam is propagated via fiber coupler.Wherein second
Road light beam is divided into third light beam and the 4th light beam, and third light beam bidirectionally successively propagates to collimator, grating, collimator, optical fiber
Coupler and balanced detector, similarly, the 4th light beam bidirectionally successively propagate to fiber coupler, collimator, fiber coupler
And balanced detector.Final beam is back in the fiber coupler that beam propagation is gone out.
Respectively by the light beam of adaptive optics scanning laser ophthalmoscope AOSLO and optical coherent chromatographic imaging OCT two
Color crosses to Jing Chu, bidirectionally propagates to human eye.
Obviously, above-described embodiment is only intended to clearly illustrate example, and does not limit the embodiments.For
For those of ordinary skill in the art, other various forms of variations or change can also be made on the basis of the above description
It is dynamic.There is no necessity and possibility to exhaust all the enbodiments.And obvious variation extended from this or change
It moves still within the protection scope of the invention.
Claims (9)
1. a kind of cone cell imaging device, which is characterized in that described device includes adaptive optics scanning laser ophthalmoscope
(AOSLO), optical coherent chromatographic imaging (OCT) and imaging processing device, wherein adaptive optics scanning laser ophthalmoscope
It (AOSLO) include first light source module, Wavefront detecting module, Corrective control module, scan module；Optical coherent chromatographic imaging
It (OCT) include second light source module, intervention module and interference signal receiving module.
2. cone cell imaging device according to claim 1, which is characterized in that adaptive optics scanning laser ophthalmoscope
It (AOSLO) further include beam splitter (BS), condenser lens (FL) and photomultiplier tube (PMT).
3. cone cell imaging device according to claim 1, which is characterized in that adaptive optics scanning laser ophthalmoscope
It (AOSLO) further include 4f system and photomultiplier tube (PMT).
4. cone cell imaging device according to claim 1, which is characterized in that light source module includes laser and optical fiber
Coupler.
5. cone cell imaging device according to claim 1, which is characterized in that Wavefront detecting module includes wavefront sensing
Device.
6. cone cell imaging device according to claim 1, which is characterized in that Corrective control module includes distorting lens,
Scan module includes scanning galvanometer, and wherein scanning galvanometer includes quick transversal scanning galvanometer and longitudinal scanning galvanometer at a slow speed.
7. cone cell imaging device according to claim 1, which is characterized in that second light source module and first light source mould
Block is identical or not identical.
8. cone cell imaging device according to claim 1, which is characterized in that intervention module include Polarization Controller and
Collimating mirror.
9. cone cell imaging device according to claim 1, which is characterized in that interference signal receiving module includes spectrum
Instrument module and balanced detector, spectrometer module include grating, condenser lens and camera, and wherein grating is diffraction grating, camera
For linear camera, imaging processing device includes computer.
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| CN201910325949.1A CN110074752A (en) | 2019-04-23 | 2019-04-23 | A kind of cone cell imaging device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910325949.1A CN110074752A (en) | 2019-04-23 | 2019-04-23 | A kind of cone cell imaging device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111436907A (en) * | 2020-04-17 | 2020-07-24 | 佛山科学技术学院 | Cerebrovascular imaging device based on sweep frequency adaptive optics OCT |
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