CN210408384U

CN210408384U - Cone cell imaging device

Info

Publication number: CN210408384U
Application number: CN201920552423.2U
Authority: CN
Inventors: 邓卓健; 吴小翠
Original assignee: Guangdong Weiren Medical Technology Co ltd
Current assignee: Guangdong Weiren Medical Technology Co ltd
Priority date: 2019-04-23
Filing date: 2019-04-23
Publication date: 2020-04-28
Anticipated expiration: 2029-04-23

Abstract

The utility model provides a pair of cone cell image device, including Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO), Optics Coherent Tomography (OCT) and formation of image processing apparatus, will go into the light beam of the cone cell of eye ground through Optics Coherent Tomography (OCT) and handle the back of returning, again with the light beam through Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO) handle the back and carry out interference processing to send the interference signal of handling to the three-dimensional image that the formation of image processing apparatus generated the high accuracy, can realize observing the activity condition of the cone cell of eye ground.

Description

Cone cell imaging device

Technical Field

The present invention relates generally to an imaging device, and more particularly to a cone cell imaging device.

Background

The application of Adaptive Optics (AO) in ophthalmology is that various aberrations of an optical system can be adaptively corrected through a wavefront receptor-wavefront controller, and the transverse resolution of the system is greatly improved. The human eye is an optical system, and various aberrations often exist in the optical system in the process of measuring the human eye, so that the imaging quality is seriously influenced. The introduction of adaptive optics technology into optical systems can solve this problem. This patent will combine together Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO) and Optical Coherence Tomography (OCT), greatly improve the resolution ratio of system on two-dimensional space, observe the retina layer activity condition that its cone cell level activity arouses, can assess cone cell activity ability.

Because the cone cells can receive light stimulation and convert the light energy into nerve impulses, the cone cells contain photosensitive substances (rhodopsin). Under the stimulation of light, the photosensitive substance can generate a series of photochemical changes and potential changes, so that the cone cells generate nerve impulses. The utility model discloses accessible light source broadband light stimulation retina is last to the cone cell layer, observes the motion condition to each layer of retina when cone cell sends nerve impulse. Dynamic information of the retina is extracted from the acquired three-dimensional image information of the retina, and the activity of the cells is analyzed so as to evaluate the retina light sensing process.

The visual cells are the photosensitive nerves of the retina, and the cone cells are the important parts of the visual cells, mainly distributed in the fovea region, and the important function is to distinguish colors, wherein three types of cone cells which are particularly sensitive to different wavelengths exist in the retina, one type of cone cells has an absorption peak value outside 420nm, one type of cone cells has an absorption peak value outside 531nm, and the other type of cone cells has an absorption peak value outside 558nm, and basically corresponds to the wavelength of blue, green and red light. The onset of the red-green achromatopsia is closely related to the activity of cone cells, so that the observation of the activity condition of the cone cells has important significance for the research of the achromatopsia diseases.

The related technologies close to the utility model are as follows: the self-adaptive optical laser ophthalmoscope principle mentioned in the laser diffraction line scanning confocal ophthalmoscope system (CN201210523966.4) and the scanning optical image acquisition equipment with the self-adaptive optical system and the control method thereof (CN201080016622.3) is different from the application of the system, but the patent is combined with the optical coherence tomography technology and aims to observe the movement of each layer of retina caused by the stimulation of cone cells and make up the blank in the field of cone cell movement detection.

SUMMERY OF THE UTILITY MODEL

In order to overcome the defects of the prior art, the utility model provides a cone cell imaging device, which can realize the activity condition of the cone cells of the eyeground.

In order to realize the technical effect, the utility model discloses a following technical scheme:

an optical cone cell imaging apparatus comprising an Adaptive Optical Scanning Laser Ophthalmoscope (AOSLO), an Optical Coherence Tomography (OCT), and an imaging processing apparatus, wherein the Adaptive Optical Scanning Laser Ophthalmoscope (AOSLO) comprises a first light source module, a wavefront detection module, a correction control module, a scanning module; the Optical Coherence Tomography (OCT) includes a second light source module, an interference module, and an interference signal receiving module.

As an improvement of the above technical solution, the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO) further comprises a Beam Splitter (BS), a Focusing Lens (FL), and a photomultiplier tube (PMT).

As an improvement of the above technical solution, the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO) further comprises a 4f system and a photomultiplier tube (PMT).

As an improvement of the above technical solution, the light source module includes a laser and a fiber coupler.

As an improvement of the above technical solution, wherein the wavefront sensing module includes a wavefront sensor.

As an improvement of the above technical solution, the calibration control module comprises a deformable mirror, the scanning module comprises a scanning galvanometer, and the scanning galvanometer comprises a fast transverse scanning galvanometer and a slow longitudinal scanning galvanometer.

As an improvement of the above technical solution, the second light source module is the same as or different from the first light source module.

As an improvement of the above technical solution, the interference module includes a polarization controller and a collimator lens.

As an improvement of the above technical solution, the interference signal receiving module includes a spectrometer module and a balanced detector, the spectrometer module includes a grating, a focusing lens and a camera, the grating is a diffraction grating, the camera is a linear camera, and the imaging processing device includes a computer.

The technical effects are as follows:

the utility model provides a pair of cone cell image device, including Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO), Optics Coherent Tomography (OCT) and formation of image processing apparatus, will go into the light beam of the cone cell of eye ground through Optics Coherent Tomography (OCT) and handle the back of returning, again with the light beam through Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO) handle the back and carry out interference processing, and send the interference signal who handles to the formation of image processing apparatus and generate the three-dimensional image of high accuracy, can realize observing the activity condition of the cone cell of eye ground clearly.

Drawings

The following and other advantages and features will be more fully understood from the following detailed description of embodiments thereof, with reference to the accompanying drawings, which must be considered in an illustrative and non-limiting manner, in which:

fig. 1 is a block diagram of a cone imaging device according to an embodiment of the present invention;

fig. 2 is a schematic diagram of a cone imaging device according to another embodiment of the present invention.

Detailed Description

The conception, specific structure and technical effects of the present invention will be described clearly and completely with reference to the accompanying drawings and embodiments, so as to fully understand the objects, aspects and effects of the present invention. It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.

It should be noted that, unless otherwise specified, when a feature is referred to as being "fixed" or "connected" to another feature, it may be directly fixed or connected to the other feature or indirectly fixed or connected to the other feature. Furthermore, the description of the upper, lower, left, right, etc. used in the present invention is only relative to the mutual positional relationship of the components of the present invention in the drawings. As used in this specification and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

Furthermore, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. The terminology used in the description herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any combination of one or more of the associated listed items.

It will be understood that, although the terms first, second, third, etc. may be used herein to describe various elements, these elements should not be limited by these terms. These terms are only used to distinguish one element of the same type from another. For example, a first element could be termed a second element, and, similarly, a second element could be termed a first element, without departing from the scope of the present disclosure. The word "if" as used herein may be interpreted as "at … …" or "at … …" depending on the context.

Fig. 1 is a block diagram of a system according to an embodiment of the present invention. As shown in fig. 1, the present invention provides a device comprising an adaptive optical scanning laser ophthalmoscope AOSLO, an optical coherence tomography OCT, and a processing device, wherein the adaptive optical scanning laser ophthalmoscope AOSLO comprises a first light source module, a wavefront detection module, a calibration control module, and a scanning module; the optical coherence tomography OCT comprises a second light source module, an interference module and an interference signal receiving module.

In an embodiment of the present invention, preferably, the first light source module includes a laser and a fiber coupler, wherein the laser is used for continuously emitting light source, the laser may be a super-radiation semiconductor laser, and the laser may also be a super-continuous light source SCL.

In an embodiment of the present invention, preferably, the wavefront sensor module includes a wavefront sensor WVS for acquiring a wavefront aberration.

In an embodiment of the present invention, preferably, wherein the calibration control module includes a deformable mirror DM, the angle of the light can be controlled by changing the mirror surface angle of the deformable mirror.

In an embodiment of the present invention, preferably, the scanning module includes a scanning galvanometer, wherein the scanning galvanometer includes a fast transverse scanning galvanometer FS and a slow longitudinal scanning galvanometer SS for scanning the fundus, and the fast transverse scanning galvanometer FS and the slow longitudinal scanning galvanometer SS combine to scan and then converge the light on the retinal layer of the fundus retina on the retinal layer.

In an embodiment of the present invention, preferably, the second light source module is the same as the first light source module.

In another embodiment of the present invention, preferably, the second light source module is different from the first light source module.

In an embodiment of the present invention, preferably, the interference module includes a polarization controller PC and a collimating mirror CL.

In an embodiment of the present invention, preferably, wherein the interference signal receiving module includes a grating, a focusing lens and a camera, wherein the grating is a diffraction grating, and the camera is a linear camera.

In an embodiment of the present invention, preferably, wherein the image processing apparatus includes a computer.

As shown in fig. 1, the specific light path direction is as follows: broadband light emitted by a supercontinuum light source SCL firstly enters an optical fiber coupler FOC and then is divided into two beams of light, the first beam of light enters an adaptive optics scanning laser ophthalmoscope AOSLO (also called a reference arm), and the second beam of light enters optical coherence tomography OCT. In detail, the first beam of light passes through the third polarization controller PC3, is collimated by the first collimating lens CL1, is focused by the second focusing lens FL2, and is transmitted to the plane mirror M, and the plane mirror M returns the first beam of light to the optical fiber coupler FOC according to the principle of reflection.

The second beam is processed by the first polarization controller PC1, and enters into the first curved mirror CM1 and the second curved mirror CM2 through the dichroic mirror DRM and the first beam splitter BS, the first curved mirror CM1 and the second curved mirror CM2 compose the first confocal system for eliminating the system stray light, the second beam processed by the confocal system enters into the deformable mirror DM, the incident angle of the second beam can be adjusted by controlling and changing the mirror surface angle of the deformable mirror DM, then passes through the second confocal system composed of the third curved mirror CM3 and the fourth curved mirror CM4, then passes through the combination of the fast transverse scanning galvanometer FS and the slow longitudinal scanning galvanometer SS to process the second beam, wherein the fifth curved mirror CM5 and the sixth curved mirror CM6 are further arranged between the fast transverse scanning galvanometer FS and the slow longitudinal scanning galvanometer SS, and then passes through the seventh curved mirror CM7 and the eighth curved mirror CM8 to transmit the second beam FM1 to the first flat mirror FM1, and then transmitted to the cone cells through a second flat mirror FM 2. The second light beam returning from the cone cells of the fundus returns to the first beam splitter BS1 in the original path, enters the micro lens array LEA and the wavefront sensor WVS through the second beam splitter BS2, acquires wavefront aberration through the wavefront sensor WVS, returns to control the deformable mirror to correct the wavefront aberration, and then returns to the fiber coupler FOC.

At this point, a first light beam returned from the adaptive optics scanning laser ophthalmoscope AOSLO interferes with a second light beam returned from the optical coherence tomography OCT, the interference is processed by a second polarization controller PC2, the interference is transmitted to a second collimating mirror CL2 for collimation, the interference is transmitted to a first focusing lens FL1 after being processed by a grating G, the interference is transmitted to a camera, and the interference is transmitted to a computer device through the camera after the camera receives data, and the interference is processed into the three-dimensional imaging of the cone cells.

By combining the optical coherence tomography OCT and the optical coherence tomography OCT, the motion condition of each layer of retina of the eyeground can be corrected by self-adaption to optical signals of human eye aberration, and high-precision human eye images are presented.

Because the cone cells can receive light stimulation and convert the light energy into nerve impulses, the cone cells contain photosensitive substances (rhodopsin). Under light stimulation, the photosensitive substance can generate a series of photochemical changes and potential changes, so that the cone cells send out nerve impulses. The utility model discloses accessible light source broadband light stimulation retina is last to the cone cell layer, observes the motion condition to each layer of retina when cone cell sends nerve impulse. Dynamic information of the retina is extracted from the acquired three-dimensional image information of the retina, and the activity of the cells is analyzed so as to evaluate the retina light sensing process.

In addition, the adaptive optical path is combined with a laser ophthalmoscope. The laser ophthalmoscope system comprises a light source SCL, a collimating lens CL3, a beam splitter BS, a focusing lens FL3 and a photomultiplier tube PMT. Because the photomultiplier PMT receives the optical signal of the human eye aberration corrected by the adaptive optical path, the photomultiplier PMT can obviously multiply the processed optical signal, and the processed optical signal can present a high-precision human eye image after being processed by a computer.

Fig. 2 is a schematic diagram of a cone imaging apparatus according to another embodiment of the present invention. The cone cell imaging device comprises an adaptive optics scanning laser ophthalmoscope AOSLO and an optical coherence tomography OCT. The light beam to the human eye is divided into two paths, the first path of light beam comes from an adaptive optical scanning laser ophthalmoscope AOSLO, and the second path of light beam comes from an optical coherence tomography OCT.

The adaptive optical scanning laser ophthalmoscope AOSLO comprises a light source, an attenuator, a spectroscope, a curved mirror, a galvanometer, a 4f system and a photomultiplier. The optical coherence tomography OCT includes a scanning light source, a fiber coupler, a balanced detector, a collimator, and a grating. In the AOSLO module of the self-adaptive optical scanning laser ophthalmoscope, a first path of light beam starts from a light source and an attenuator, and is transmitted to a dichroic mirror in a bidirectional way along a spectroscope, a curved mirror, a vibrating mirror, a curved mirror and a vibrating mirror, wherein the dichroic mirror divides a light beam, and the light beam is transmitted to a 4f system in a unidirectional way and is transmitted to a photomultiplier in sequence.

In the OCT module, a swept-frequency light source emits a light beam to be transmitted to an optical fiber coupler, and the light beam is divided into two paths of light beams by the optical fiber coupler, wherein the first path of light beam is transmitted out of the OCT module and is sequentially transmitted to a collimator, a vibrating mirror, a 4f system and a dichroic mirror; the second beam propagates through the fiber coupler. The second light beam is divided into a third light beam and a fourth light beam, the third light beam is transmitted to the collimator, the grating, the collimator, the optical fiber coupler and the balance detector in sequence in a bidirectional mode, and the fourth light beam is transmitted to the optical fiber coupler, the collimator, the optical fiber coupler and the balance detector in sequence in the bidirectional mode in the same manner. The light beam is finally returned to the fiber coupler from which it is to be propagated.

The beams respectively passing through the adaptive optical scanning laser ophthalmoscope AOSLO and the optical coherence tomography OCT are converged at the dichroic mirrors and bidirectionally propagate to the human eye.

It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications can be made without departing from the scope of the invention.

Claims

1. An apparatus for imaging a cone of view, the apparatus comprising an Adaptive Optical Scanning Laser Ophthalmoscope (AOSLO) including a first light source module, a wavefront sensing module, a correction control module, a scanning module, an Optical Coherence Tomography (OCT) and an imaging processing apparatus; the Optical Coherence Tomography (OCT) includes a second light source module, an interference module, and an interference signal receiving module.

2. The cone imaging device according to claim 1, wherein the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO) further comprises a Beam Splitter (BS), a Focusing Lens (FL), and a photomultiplier tube (PMT).

3. The cone imaging device of claim 1, wherein the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO) further comprises a 4f system and a photomultiplier tube (PMT).

4. The apparatus according to claim 1, wherein the light source module comprises a laser and a fiber coupler.

5. The apparatus according to claim 1, wherein the wavefront sensing module comprises a wavefront sensor.

6. The apparatus according to claim 1, wherein the calibration control module comprises a deformable mirror and the scanning module comprises a scanning galvanometer, wherein the scanning galvanometer comprises a fast transverse scanning galvanometer and a slow longitudinal scanning galvanometer.

7. The apparatus according to claim 1, wherein the second light source module is the same as or different from the first light source module.

8. The apparatus according to claim 1, wherein the interference module comprises a polarization controller and a collimator lens.

9. The apparatus according to claim 1, wherein the interference signal receiving module comprises a spectrometer module and a balance detector, the spectrometer module comprises a grating, a focusing lens and a camera, wherein the grating is a diffraction grating, the camera is a linear camera, and the imaging processing apparatus comprises a computer.