CN110051583A - It is a kind of to treat acne mildy wash and preparation method thereof - Google Patents
It is a kind of to treat acne mildy wash and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
Acne mildy wash and preparation method thereof is treated the invention discloses a kind of, it is made of the following components: lauric acid, myristic acid, stearic acid, glycerol, polyethylene glycol 400,1,2- hexylene glycol, parahydroxyacet-ophenone, potassium hydroxide, disodium ethylene diamine tetraacetate, polyquaternium -7, glycerin monostearate, laureth sodium sulfovinate, white tea polyphenol, tocopherol, Radix Arnebiae extract, purslane extract, dipotassium glycyrrhizinate, Gotu Kola P.E, Chiba rose hydrosol；Preparation method includes the following steps: producing A phase and B phase mixture respectively with part material；B phase mixture is added in A phase and is stirred；Glycerin monostearate, laureth sodium sulfovinate, stirring is added；White tea polyphenol, tocopherol, Radix Arnebiae extract, purslane extract, dipotassium glycyrrhizinate, Gotu Kola P.E, Chiba rose hydrosol is added, stirs evenly, discharging obtains finished product.The present invention, which treats acne, has good effect.
Description
Technical field
The present invention relates to cosmetic technical field more particularly to a kind of treat acne mildy wash and preparation method thereof.
Background technique
Acne is commonly called as " whelk ", also known as " acne ", " acne ", " dark sore " etc., is usually apt to occur in face, neck, thoracic dorsal
Portion, shoulder and upper arm.It is a kind of chronic inflammatory skin of pilosebaceous unit, and clinic is with Whiteheads, blackhead powder
Thorn, inflamed papules, warts, tubercle, tumour etc. are main performance.This disease puberty is common, but also not exclusively by year age grade
The limitation of section, from children to adult, the people of nearly all age bracket can fall ill.With the development of the social economy, environment is dirty
The factors such as dye, bacterium infection, cosmetics stimulation can cause people's facial skin to be stimulated and acne reaction occurs, and influence face
Portion's skin beauty.
As people like to be beautiful the reinforcement of consciousness, many anti-acne class products emerge in large numbers on the market, but many products warps on the market
The exaggeration packaging for crossing marketing methods, exaggerates and declares its effect, misguide the consumer consumption, and many product effects are not significant or do not have
Effect, or addition forbidden amphetamine, lead to the secondary damage of skin.
The present invention uses anhydrous formulations, improves the big problem of the irritation generated in formula by the permeability of water, together
When according to the cutaneous gene examining report of different people, skin physiology, dermatopathology, skin instantly situation, season, the age,
The dimension scientific design of region seven customizes skin care scheme, and user is allowed to possess the Product Experience as accurate skin care, personal customization.
Summary of the invention
In view of the deficiencies of the prior art, technical problem solved by the invention is that mildy wash how to be made to have treatment acne function
Effect.
In order to solve the above technical problems, the technical solution adopted by the present invention is that a kind of treat acne mildy wash, by with the following group
Point mass percent is made: lauric acid 4%-8%, myristic acid 5%-8%, stearic acid 12%-20%, glycerol 4%-6%, poly-
Ethylene glycol 400 is 10%-18%, 1,2- hexylene glycol 1%-5%, parahydroxyacet-ophenone 0.1%-0.8%, potassium hydroxide 3%-
8%, disodium ethylene diamine tetraacetate 0.1%-0.3%, polyquaternium -7 are 2%-4%, glycerin monostearate 1%-3%, the moon
Laureth sodium sulfovinate 5%-10%, white tea polyphenol 1%-3%, tocopherol 1%-3%, Radix Arnebiae extract 5%-8%, dent
Amaranth extract 5%-8%, dipotassium glycyrrhizinate 1%-3%, Gotu Kola P.E 1%-3%, Chiba rose hydrosol 18%-22%.
Preferably, a kind of to treat acne mildy wash, it is made of following components mass percent: lauric acid 5%, myristic acid
5%, stearic acid 18%, glycerol 4%, polyethylene glycol 400 10%, 1,2- hexylene glycol 4%, parahydroxyacet-ophenone 0.5%, hydrogen-oxygen
Changing potassium 3%, disodium ethylene diamine tetraacetate 0.1%, polyquaternium -7 is 4%, glycerin monostearate 3%, laureth sulphur
Acid esters sodium 5%, white tea polyphenol 3%, tocopherol 1%, Radix Arnebiae extract 5%, purslane extract 5%, dipotassium glycyrrhizinate 1%,
Gotu Kola P.E 3%, Chiba rose hydrosol 20.4%.
The invention solves another technical problem be to provide the preparation method of above-mentioned treatment acne mildy wash.
For this purpose, technical solution provided by the invention is a kind of preparation method for treating acne mildy wash, comprising the following steps:
(1) by lauric acid, myristic acid, stearic acid, glycerol, polyethylene glycol 400,1,2- hexylene glycol, parahydroxyacet-ophenone
It is mixed to get A phase；
(2) A phase is heated with stirring to 85 DEG C, system is completely dissolved, insulated and stirred 5min；
(3) potassium hydroxide, disodium ethylene diamine tetraacetate are mixed to get B phase；
(4) B phase is heated with stirring to 85 DEG C, be completely dissolved, insulated and stirred 10min or more；
(5) B is added in A phase, mixing speed is from slow to fast, it is ensured that be formed by soap group and broken up, keep 80 DEG C with
Upper temperature is saponified 50min, medium speed's defoaming；
(6) glycerin monostearate, laureth sodium sulfovinate are added when being cooled to 60 DEG C after being saponified, stirring is equal
It is even；
(7) white tea polyphenol, tocopherol, Radix Arnebiae extract, purslane extract, glycyrrhizic acid two are added after being cooled to 45 DEG C
Potassium, Gotu Kola P.E, Chiba rose hydrosol, stir evenly, and discharging obtains finished product.
Compared with prior art, beneficial effects of the present invention:
Adding Radix Arnebiae extract has efficient bacteriostasis, adjusts lipid material balance, inhibits microorganism mistake indirectly
Degree breeding, to play the role for the treatment of acne；
Chiba rose hydrosol etc. can be obviously improved the health status of skin, promote the self-regeneration of skin；
Deionized water is replaced using Chiba rose hydrosol, anti-acne essence is made to have both treatment acne, healthy skin of releiving
Effect.
Tea polyphenols are added, enhances red blood cell free radical scavenging ability and makes cell membrane from oxidative damage, be natural
Antioxidant, reduce clogging of pores problem caused by skin damages, the health status of skin can be reinforced, to effectively treat Cuo
Sore；
In conclusion the present invention has good effect to acne treatment.
Specific embodiment
A specific embodiment of the invention is further described below with reference to embodiment, but is not to limit of the invention
It is fixed.
Embodiment 1:
It is a kind of to treat acne mildy wash, it is made of following components mass percent: lauric acid 5%, myristic acid 5%, hard
Resin acid 18%, glycerol 4%, polyethylene glycol 400 11.4%, 1,2- hexylene glycol 4%, parahydroxyacet-ophenone 0.5%, potassium hydroxide
5%, disodium ethylene diamine tetraacetate 0.1%, polyquaternium -7 are 4%, glycerin monostearate 3%, laureth sulfuric ester
Sodium 8%, white tea polyphenol 1%, tocopherol 1%, Radix Arnebiae extract 5%, purslane extract 5%, dipotassium glycyrrhizinate 1%, accumulated snow
Careless extract 1%, Chiba rose hydrosol 18%.
Embodiment 2:
It is a kind of to treat acne mildy wash, it is made of following components mass percent: lauric acid 5%, myristic acid 5%, hard
Resin acid 18%, glycerol 4%, polyethylene glycol 400 10%, 1,2- hexylene glycol 4%, parahydroxyacet-ophenone 0.5%, potassium hydroxide
3%, disodium ethylene diamine tetraacetate 0.1%, polyquaternium -7 are 4%, glycerin monostearate 3%, laureth sulfuric ester
Sodium 5%, white tea polyphenol 3%, tocopherol 1%, Radix Arnebiae extract 5%, purslane extract 5%, dipotassium glycyrrhizinate 1%, accumulated snow
Careless extract 3%, Chiba rose hydrosol 20.4%.
Embodiment 3:
It is a kind of to treat acne mildy wash, it is made of following components mass percent: lauric acid 4%, myristic acid 5%, hard
Resin acid 12.8%, glycerol 4%, polyethylene glycol 400 10%, 1,2- hexylene glycol 1%, parahydroxyacet-ophenone 0.1%, potassium hydroxide
3%, disodium ethylene diamine tetraacetate 0.1%, polyquaternium -7 are 4%, glycerin monostearate 1%, laureth sulfuric ester
Sodium 5%, white tea polyphenol 3%, tocopherol 3%, Radix Arnebiae extract 8%, purslane extract 8%, dipotassium glycyrrhizinate 3%, accumulated snow
Careless extract 3%, Chiba rose hydrosol 22%.
1 to 3 preparation method of above-described embodiment, is made up of following steps:
(1) by lauric acid, myristic acid, stearic acid, glycerol, polyethylene glycol 400,1,2- hexylene glycol, parahydroxyacet-ophenone
It is mixed to get A phase；
(2) A phase is heated with stirring to 85 DEG C, system is completely dissolved, insulated and stirred 5min；
(3) potassium hydroxide, disodium ethylene diamine tetraacetate are mixed to get B phase；
(4) B phase is heated with stirring to 85 DEG C, be completely dissolved, insulated and stirred 10min or more；
(5) B is added in A phase, mixing speed is from slow to fast, it is ensured that be formed by soap group and broken up, keep 80 DEG C with
Upper temperature is saponified 50min, medium speed's defoaming；
(6) glycerin monostearate, laureth sodium sulfovinate are added when being cooled to 60 DEG C after being saponified, stirring is equal
It is even；
(7) white tea polyphenol, tocopherol, Radix Arnebiae extract, purslane extract, glycyrrhizic acid two are added after being cooled to 45 DEG C
Potassium, Gotu Kola P.E, Chiba rose hydrosol, stir evenly, and discharging obtains finished product.
Beneficial effect in order to better illustrate the present invention carries out efficacy assessments experiment.
Through the invention to staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 9027, Escherichia coli ATCC
8739, the bacteriostatic experiment of Candida albicans ATCC 10231, microsporon furfur, propionibacterium acnes, efficacy assessments are divided into
Three-level: it is effective, effective and invalid, be determined as when cosmetics are all larger than equal to 90% above-mentioned strain bacteriostasis rate it is effective, when right
First three strain fungistatic effect is more than or equal to 90% and is determined as when being more than or equal to 50%-90% to latter three kinds effectively, as long as right
Three kinds of strain bacteriostasis rates are determined as in vain less than 50% afterwards.
Culture medium and condition of culture:
(37 DEG C, 48h culture, are used for staphylococcus aureus, Lv Nong Wilsonii bacterium, great Chang Wilsonii bacterium to ordinary nutrient agar culture medium
Culture)；Sabouraud's agar (30 DEG C, 3 days are cultivated, and Candida albicans culture is used for)；Improvement is husky to protect Ruo Shi agar medium
(30 DEG C, 3 days are cultivated, and microsporon furfur culture is used for): dextrose broth (37 DEG C, 48h Anaerobic culturel, in acne
Acidfast bacilli culture).
Test method: referring to National Standard of the People's Republic of China GB15797-2002, " Disposable Sanitary Accessory is defended
Appendix C 4 " stripping property resists (suppression) bacterium product bacteriostasis property test method " in raw standard ".
Operating procedure:
(1) test organisms for 24 hours washed down with 0.03ml/L PBS by (bacterium) and 5 days (fungi) cultures, and 10cfu/mL bacterium is made
Suspension；
(2) it takes and above-mentioned bacteria suspension 0.1mL even spread mixing is added by test agent 1g, after starting timing 20min, be added
9mL 0.03mol/L PBS is mixed well, and after making appropriate dilution, takes wherein 2-3 dilutions, 1mL is taken to be placed in two respectively
In parallel plate, corresponding culture medium difference Hybrid NC machine tool is added, colony count is made.The above test is repeated 3 times, and takes it average
Number, while setting blank control, calculates: X=(A-B)/Ax100%, and in formula: X bacteriostasis rate, mono- control sample of %, A averagely recycle bacterium
It falls, mono- test specimen of B averagely recycles bacterium colony；
(3) result reports that bacteriostasis rate >=50%-90%, product have bacteriostasis；Bacteriostasis rate >=90%, product have stronger suppression
Bacterium effect.
The experimental results are shown inthe following table:
| Strain | Bacteriostasis rate |
| Staphylococcus aureus ATCC 6538 | >=90% |
| Pseudomonas aeruginosa ATCC 9027 | >=90% |
| Escherichia coli ATCC 8739 | >=90% |
| Candida albicans ATCC 10231 | >=90% |
| Microsporon furfur | >=90% |
| Propionibacterium acnes | >=90% |
The experimental results showed that the present invention has apparent bacteriostasis, explanation for the strains for causing acne several in table
The present invention has good effect for the treatment of acne.
Detailed description is made that embodiments of the present invention in conjunction with the embodiments above, but the present invention be not limited to it is described
Embodiment.To those skilled in the art, without departing from the principles and spirit of the present invention, to these realities
The mode of applying carries out various change, modification, replacement and variant are still fallen in protection scope of the present invention.
Claims (3)
1. a kind of treat acne mildy wash, which is characterized in that be made of following components mass percent: lauric acid 4%-8%, meat
Myristic acid 5%-8%, stearic acid 12%-20%, glycerol 4%-6%, polyethylene glycol 400 10%-18%, 1,2- hexylene glycol
1%-5%, parahydroxyacet-ophenone 0.1%-0.8%, potassium hydroxide 3%-8%, disodium ethylene diamine tetraacetate 0.1%-0.3%,
Polyquaternium -7 is 2%-4%, glycerin monostearate 1%-3%, laureth sodium sulfovinate 5%-10%, white tea polyphenol
1%-3%, tocopherol 1%-3%, Radix Arnebiae extract 5%-8%, purslane extract 5%-8%, dipotassium glycyrrhizinate 1%-
3%, Gotu Kola P.E 1%-3%, Chiba rose hydrosol 18%-22%.
2. treatment acne mildy wash according to claim 1, which is characterized in that be made of following components mass percent:
Lauric acid 5%, myristic acid 5%, stearic acid 18%, glycerol 4%, polyethylene glycol 400 10%, 1,2- hexylene glycol 4%, to hydroxyl
Benzoylformaldoxime 0.5%, potassium hydroxide 3%, disodium ethylene diamine tetraacetate 0.1%, polyquaternium -7 are 4%, glycerol monostearate
Ester 3%, laureth sodium sulfovinate 5%, white tea polyphenol 3%, tocopherol 1%, Radix Arnebiae extract 5%, purslane extract
5%, dipotassium glycyrrhizinate 1%, Gotu Kola P.E 3%, Chiba rose hydrosol 20.4%.
3. a kind of preparation method for the treatment of acne mildy wash as claimed in claim 1 or 2, which is characterized in that including following step
It is rapid:
(1) lauric acid, myristic acid, stearic acid, glycerol, polyethylene glycol 400,1,2- hexylene glycol, parahydroxyacet-ophenone are mixed
Obtain A phase；
(2) A phase is heated with stirring to 85 DEG C, system is completely dissolved, insulated and stirred 5min；
(3) potassium hydroxide, disodium ethylene diamine tetraacetate are mixed to get B phase；
(4) B phase is heated with stirring to 85 DEG C, be completely dissolved, insulated and stirred 10min or more；
(5) B is added in A phase, mixing speed is from slow to fast, it is ensured that be formed by soap group and broken up, keep 80 DEG C or more temperature
Degree saponification 50min, medium speed's defoaming；
(6) glycerin monostearate, laureth sodium sulfovinate is added when being cooled to 60 DEG C after being saponified, stirs evenly；
(7) white tea polyphenol, tocopherol, Radix Arnebiae extract, purslane extract, dipotassium glycyrrhizinate, product are added after being cooled to 45 DEG C
Careless extract, Chiba rose hydrosol are avenged, is stirred evenly, discharging obtains finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910343835.XA CN110051583A (en) | 2019-04-26 | 2019-04-26 | It is a kind of to treat acne mildy wash and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910343835.XA CN110051583A (en) | 2019-04-26 | 2019-04-26 | It is a kind of to treat acne mildy wash and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN110051583A true CN110051583A (en) | 2019-07-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116725928A (en) * | 2023-08-14 | 2023-09-12 | 广东尚品汇生物科技有限公司 | Anti-allergy acne-removing traditional Chinese medicine composition, and preparation method and application thereof |
-
2019
- 2019-04-26 CN CN201910343835.XA patent/CN110051583A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116725928A (en) * | 2023-08-14 | 2023-09-12 | 广东尚品汇生物科技有限公司 | Anti-allergy acne-removing traditional Chinese medicine composition, and preparation method and application thereof |
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