CN110025682A - A kind of drug for treating rheumatoid arthritis - Google Patents

Abstract

Disclosure of the invention a kind of drug for treating arthralgia due to wind-cold-dampness disease, active pharmaceutical ingredient are made of monkshood, radix aconiti agrestis, dark plum, Radix Glycyrrhizae and white sugar.The drug has dispelling cold and dehumidification, searches wind and removing obstruction in channels, activating microcirculation and removing stasis medicinal or antalgic effect, for treating arthralgia due to wind-cold-dampness disease, especially for treating intractable rheumatism bone disease caused by rheumatic arthritis, rheumatoid arthritis, cervical spondylosis, scapulohumeral periarthritis, sciatica, the protrasion of the lumbar intervertebral disci or a variety of causes.

Description

A kind of drug for treating rheumatoid arthritis

Technical field

The present invention provides a kind of drug for treating arthralgia due to wind-cold-dampness disease, in particular, provides and a kind of treats rheumatoid arthritis Drug.Belong to field of traditional Chinese medicine pharmacy.

Background technique

Modern medicine is thought: rheumatic arthritis, rheumatoid arthritis, sciatica, cervical spondylosis, scapulohumeral periarthritis, waist Disc herniation disease etc., category impediment syndrome range." numbness " occludes obstructed meaning, " blood flow then leads to, thromboembolism then numbness ", therefore " scape Yue Quanshu " say: " numbness person closes, and is closed with vim and vigour by heresy, must not pass through and it is sick also ".Since the exopathogens such as wind, cold, wet, heat are invaded Human body, impatency channels and collaterals, caused by QI-blood circulation is unsmooth with muscle, muscles and bones, joint is ached, numbness, is weighed, joint stuffiness, The even scorching hot illness waited as main clinical manifestation of arthrocele, referred to as rheumatism.

" rheumatism " is apt to occur in joint more than weight-bearing activities, neck waist thoracic vertebrae, knee, finger, heel etc., that is, due to human body After fleshy exterior joint wind-engaging, cold, heat, wet, dry, fiery " six external factors which cause diseases " exopathogen invasion, qi and blood cannot be unobstructed, hinders in channels and collaterals muscle arthrosis, Not general rule pain, sends out and is numbness；Or because wound, long-term chronic strain, exopathogen is transdermal to go deep into marrow, deadlocked not go, then obstructed, the shape of pain At " bone poison "." bone poison " long-term existence is in bone and formation on periosteum " place poison ", that is, " six external factors which cause diseases " exopathogen occludes channels and collaterals, coagulates long not Change, wet to coagulate for phlegm, blood stops as the stasis of blood, and phlegm-blood stasis and hand over resistance is into " place poison "." place poison " make bone and periarticular soft tissues it is repeatedly congested, Oedema, adhesion, contracture generate a large amount of acidic materials stimulation blood vessels, damage muscle groups so as to cause local blood circulation obstacle It knits, shows as muscle muscles and bones joint pain, numbness, swelling, or even red and swollen deformation, severe one will cause the destruction of joint sclerotin, close Section deformation, can't take care of oneself.And long pain it is more empty, long the more stasis of bloods of pain, enter bitterly long network, long must and kidney, bitterly in bone；Shen controls bone is thus Cause the pain at muscles and bones articular muscle miserable, the pain and swelling acid of skeletal joint and its surrounding tissue is heavy numb tetanic, activity It is limited, joint stuffiness.Such disease belongs to chronic disease, and course of disease time is long, and hardly possible radical cure is easy to recur, plain stubborn.

The treatment means of doctor trained in Western medicine mostly use anti-inflammatory and antalgic class (such as non-steroidal anti-inflammatory drugs), glucocorticoids, are immunized at present The drugs such as inhibitor alleviate symptom, play certain therapeutic effect although can temporarily relieve pain, however cannot be fundamentally The disease is treated, can only be suited the medicine to the illness, palliative, treatment time is long, and weak curative effect is expensive, and there are obvious adverse reactions, no It can be used for a long time；And long-term administration can not only develop drug resistance, it is also possible to destroy human immune system, injuring nerve system, Finally there are the internal organs such as the irreversible heart, liver, kidney, stomach, intestines and seriously damage in hemopoietic system, gastrointestinal system etc., and poison is secondary to be made With very greatly, absolutely can not be ignored；And dependence is strong, it is easy to recur if being discontinued；Patient often results in because of Long-term Hormone Hormone syndrome, keeps patient more painful or even many Case treatment expenses increase, and arrives because of disease poor, to lose treatment letter The courage that the heart is even lived

Especially rheumatoid arthritis is universally acknowledged difficult disease.Currently, doctor trained in Western medicine controlling for rheumatoid arthritis It treats, different opinions are respectively held one and said.There is so-called " classical pyramid " mode；So-called " inverted pyramid " mode, that is, starting treatment just makes Change the antirheumatic drug of the state of an illness with strong drug, such as cytotoxic immune inhibitor；So-called " leave from office stepwise ", that is, start With a variety of medication combined " encircling and suppressings ", then composition of medicine is gradually deactivated respectively, is finally selected a kind of effective and Small side effects Drug maintains；So-called " wave " mode is subject to interim treatment that is, on the basis of a kind of drug therapy, in the state of an illness in fluctuation Reinforcement treatment is given when rising, restores Primary Care again later, is so repeated as many times.

Traditional treatment such as massages, draws, acupuncture, physical therapy, massage, closing, ultraviolet light irradiation, although adverse reaction compared with It is small, but the still difficult affirmative of late result；And operative treatment contraindication is more, wound weight, pain is big, spends more, complication mostly and has one Fixed risk, post-operative recovery time is long, and postoperative has a possibility that recurrence.

Therefore, there is an urgent need to short treating period, curative effect is high, take safety, comprehensively effectively treatment rheumatism, atrophic diseases it is new Treatment arthralgia due to wind-cold-dampness disease drug, especially treat rheumatic arthritis drug.

Summary of the invention

The purpose of the present invention is playing Chinese medicine combination drug, across-the-board regulation bodily fuctions, it is scattered to provide a kind of wind-dispelling Cold, eliminating dampness and dredging channels can eradicate rheumathritis, rheumatoid arthritis etc. " rheumatism ", and take safe, the quick, course for the treatment of Pure Chinese medicinal preparation short, cure rate is high.

Technical solution of the present invention is as follows:

A kind of drug for treating arthralgia due to wind-cold-dampness disease is provided, active pharmaceutical ingredient be by monkshood, radix aconiti agrestis, dark plum, Radix Glycyrrhizae and White sugar composition.

Drug described above, it is preferable that wherein calculate by weight, 5-35 parts of monkshood, 5-40 parts of radix aconiti agrestis, dark plum 10- 35 parts, 1-20 parts of Radix Glycyrrhizae and 1-10 parts of white sugar.

Drug described above, it is highly preferred that wherein calculating by weight, 5-20 parts of monkshood, 5-25 parts of radix aconiti agrestis, dark plum 10-20 parts, 1-10 parts of Radix Glycyrrhizae and 1-5 parts of white sugar；Or it calculates by weight, 20-35 parts of monkshood, 25-40 parts of radix aconiti agrestis, dark plum 20-35 parts, 10-20 parts of Radix Glycyrrhizae and 5-10 parts of white sugar.

Drug described above, as one of embodiment of the invention, wherein by weight calculating, monkshood: grass Crow: dark plum: Radix Glycyrrhizae: white sugar 10:10:10:5:1.

Drug described above, wherein monkshood, radix aconiti agrestis, dark plum and/or the Radix Glycyrrhizae can be health product or processed product； The processed product can be above-mentioned each medicinal material and carry out processing processed product obtained by concocting method commonly used in the art, such as sweet Grass has honey Radix Glycyrrhizae or ginger Radix Glycyrrhizae etc. in this field.Preferably, present invention drug described above, the monkshood, Radix aconiti agrestis, dark plum, Radix Glycyrrhizae are respectively health product, i.e., without the crude drug in whole of processing.

Drug described above, monkshood, radix aconiti agrestis, dark plum and/or Radix Glycyrrhizae therein can be used as medicine for the original powder of crude drug, or Person is that extracted crude drug and/or separation extract effective component obtained and/or active component are used as medicine.The extraction is also optionally The step of further comprising separation and/or purifying.The extracting and developing, purifying can be conventional in field of traditional Chinese medicine pharmacy mention It takes, Isolation and purification method, such as water extracts, organic solvent (including but not limited to ethyl alcohol etc.) extracts etc., it can be immersion and mention It takes or heating extraction etc..

Drug described above can be made into suitable pharmaceutical dosage form with convenient to use, for example, its for liquid preparation or Person's solid pharmaceutical preparation；Preferably, the drug be liquid medicine, syrup, oral solution, capsule, tablet, pill, condensed pill, granule, Paste, applicator, sustained release or controlled release agent.

As another object of the present invention, additionally provides drug described above and preparing the medicine for treating arthralgia due to wind-cold-dampness disease It is applied in object.

Application described above, it is preferable that the drug is used for dispelling cold and dehumidification, searches wind and removing obstruction in channels, activating microcirculation and removing stasis medicinal or temperature Meridian and relieving pain.

Preferably, application described above, the drug for treat rheumatic arthritis, rheumatoid arthritis, Intractable rheumatism bone disease caused by cervical spondylosis, scapulohumeral periarthritis, sciatica, the protrasion of the lumbar intervertebral disci or a variety of causes.

Monkshood described above is female root of cohosh Cattell rhizome of Chinese monkshood Aconitum carmichaeli Debx..Property Taste: pungent, bitter, heat；It is very toxic.Return heart, liver,kidney,spleen warp.Function dispelling wind and eliminating dampness, antalgic.Alias is also known as black beak, why poison, i.e. Son, chicken poison, malicious public affairs, Geng Zi, the rhizome of Chinese monkshood.

Radix aconiti agrestis described above is the dried pieces of cohosh north rhizome of Chinese monkshood Aconitum kusnezoffii Reichb. Root.It is pungent, bitter, hot, it is very toxic.Enter liver, spleen, lung channel.Function searches wind prevailing over dampness, and eliminating cold to stop pain opens phlegm, detumescence.Alias be also known as violet, Splendid achnatherum, the rhizome of Chinese monkshood, black beak, why malicious, i.e. sub, chicken poison, malicious public affairs, Geng Zi, sleeper roe, radix aconiti agrestis, the ring rhizome of Chinese monkshood, golden crow, five poison roots, mouse Head.

Dark plum described above is that the drying of rose department plant plum Prunus mume (Sieb.) Sieb.etZuce. is closely mature Fruit.It is sour, puckery, it is mild-natured.Return liver, spleen, lung, large intestine channel.Function is astringeed the lung to stop cough, relieving diarrhea with astringents, and hemostasis is promoted the production of body fluid, claming ascaris.Alias Also known as smoked plum, yellow young, conjunction Chinese plum, Gan Zhimei.

Radix Glycyrrhizae described above is glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix The dry root of Glycyrrhiza inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..It is sweet, flat.Return heart, Lung, spleen, stomach meridian.Function is invigorated the spleen and benefited qi, clearing heat and detoxicating, moistening lung to arrest cough, relieving spasm to stop pain, coordinating the drug actions of a prescription.Alias is also known as lantern, honey Sweet, honeywort, Lu grass, state is old, well-informed, powder is careless, Herba Hedyotis cantonensis, sweet tea root, stick grass.

White sugar described above, also known as white granulated sugar, stone honey, frosting, bloom sugar etc., sweet and neutral.Enter spleen, lung channel.Function moistening lung is raw Saliva and middle emergency.Xeropulmonary cough is controlled, dry mouth is thirsty, empty gastral cavity pain.

In drug described above, great Xin is taken, big heat, the monkshood and radix aconiti agrestis of big poison are combined into the monarch and his subjects.It is dissipated in monkshood wind-dispelling temperature It trembles with fear, can both dissipate the cold-dampness of fleshy exterior, be apt to treat the numbness disease of Cold-dampness, and can the warm cold sensation of the genitalia for leading to internal organs；The positive dredging collateral of function tool temperature is to open Numbness, therefore except inside and outside cold-dampness, it is for monarch drug in a prescription.The slightly same monkshood of radix aconiti agrestis function, but it is longer than and searches wind and remove cold clearing damp, and it relieves pain eliminating impediment Effect is stronger, closes with monkshood and uses it, Wen Tongbiaoli, it is straight in Cold-dampness disease machine, therefore be ministerial drug.The all medicines of the monarch and his subjects are mostly pungent, fragrant, Dry strong product, therefore take dark plum to promote the production of body fluid and hold back liquid, it opens middle residence and closes, to prevent pungent scattered product to hurt the dry blood of saliva, the strongly fragrant mechanism of qi of temperature, is for adjutant. Radix Glycyrrhizae coordinating the drug actions of a prescription is to make, and our the monarch and his subjects are orderly, and assistant makes clearly demarcated, simultaneous righting based on eliminating evil, residence convergence again in Wen Tongzhi.So All medicines share plays dispelling cold and dehumidification, blood circulation and channel invigorating, the good effect of dispelling wind and eliminating pain altogether.

In the present invention, said components can be used as medicine with crude drug raw medicine, or be used as medicine with their any extract.Can be had It imitates acceptable auxiliary material in ingredient and/or pharmacy and together, conventionally, various common dosage forms, such as tablet, ball is made Agent, capsule, granule, oral solution, condensed pill or other pharmaceutically acceptable dosage forms or even external preparation.For example, can To grind each raw material of the invention, mixing is packed into capsule, capsule is made；Or it can be by each crude drug crude drug of the invention It grinds, is sieved, honeyed bolus or the water-bindered pill is made；Or each starting material with water of the invention can be decocted 1~4 time, it preferably 2~3 times, filters It removes slag, oral solution is made；Or each starting material with water of the invention or ethyl alcohol can be extracted 2~3 times under heating, filtrate after filtering Alcohol precipitation, then be concentrated under reduced pressure, it dries, condensed pill is made after crushing.

The pharmaceutically acceptable auxiliary material of pure Chinese medicinal preparation of the invention includes but is not limited to: starch, dextrin, Icing Sugar are low to take For hydroxypropyl cellulose, sodium carboxymethyl starch, lactose, magnesium stearate, differential silica gel, talcum powder etc..

As one of specific embodiment of the invention, by weight, 5~35 parts of Radix Aconiti is taken, 5~40 parts of Radix Aconiti Kusnezoffii, is given birth to 10~35 parts of dark plum, 1~20 part of licorice, 1~10 part of white granulated sugar, 50~65 degree 500~2000 parts of white wine, medicinal material, which impregnates, to be made Liquid medicine, oral to drink, 3 times a day, 20~30ml, 30 days courses for the treatment of, 1~4 course for the treatment of of general patient can cure every time.It can also External application embrocates 5ml liquid medicine in affected part, and daily 3~4 times.It is oral to be used cooperatively with external application, better effect.

When above-mentioned liquid medicine reaches immersion timeliness finished product, the brown Huang of wine and women-sensual pursuits, smell mellowness.All medicine compatibilities are scientific and reasonable in formula, The effect of strengthening vital QI to eliminate pathogenic factors, the efficacy of a drug is significant, has dispelling wind and eliminating dampness, and cold dispelling searches evil dredging collateral by the stasis of blood, swelling and pain relieving；And have nontoxic Side effect, safely and effectively, cure rate are high, and drug is at low cost, short treating period, the few advantage of expense；Low alcohol consumption simultaneously is except increase battalion Support except, still can gastric acid secretion, help to digest, can also inspire enthusiasm, make parteriole blood vessel dilatation, promote blood circulation And metabolism, this liquid medicine why borrow capacity for liquor with promoting blood circulation row medicine gesture.It is highly suitable for treatment rheumatic arthritis, class The cards category wind cold wetness type such as rheumatic arthritis, scapulohumeral periarthritis, cervical spondylosis, sciatica, protrusion of lumber intervertebral disc.

Preferably, pharmaceutical composition dosage of the present invention, generally with 3~50g, the raw feedstock medicine total weight of preferably 10~30g/ The amount of day uses, and can divide 1~4 application.

Above-mentioned Chinese medicine provided by the invention is developed on the basis of the experience secret recipe Jing Guo clinical verification in more than 40 years, Secret recipe proves there is dispelling cold and dehumidification by clinical verification, searches wind and removing obstruction in channels, activating microcirculation and removing stasis medicinal, definite effect of antalgic, to rheumatism Property arthritis, rheumatoid arthritis, cervical spondylosis, scapulohumeral periarthritis, sciatica, the protrasion of the lumbar intervertebral disci and a variety of causes cause Intractable rheumatism bone disease have unique curative effect, through 140 many cases have track record clinical case verify, pure Chinese medicine of the invention Preparation compatibility science, takes safety, and curative effect is rapid, uneasy to recur, total effective rate up to 94%, and in drug bulk pharmaceutical chemicals compatibility and Composition is simple, compatibility of medicines in a prescription science.Drug of the invention is suitable for being made clinical various dosage forms and uses.

Clinical therapeutic efficacy data:

(1) general information:

The present inventor so far faced the patients such as 146 rheumatism, rheumatoid arthritis (having track record) in 1975 Bed observation treatment, the age 15~75 years old, course of disease half a year~30 year were differed.

(2) diagnostic criteria:

(1) Western medicine diagnostic criteria: according to the diagnostic criteria of American Rheumatism Association (ARA) rheumatoid arthritis in 1989.

1, morning stiffness at least 1 hour continues at least 6 weeks.

2,3 or 3 or more arthritis swelling continues at least 6 weeks.

3, wrist joint, metacarpophalangeal joints or proximal phalangeal joints swelling 6 weeks or more.

4, symmetry arthroncus.

5, the x-ray photographing of hand should have typical rheumatoid arthrosis to change and must include rotten to the corn and sclerotin decalcification.

6, rheumatoid nodules.

7, rheumatoid factor positive.

Having above-mentioned 4 can make a definite diagnosis.

By stages:

A, early stage: most affected joints have swelling and pain and limitation of activity, but x-ray only shows soft tissue swelling.

B, mid-term: part affected joints functional activity is obviously limited, and X-ray film display joint space narrows and corruption in various degree Erosion.

C, advanced stage: there are various deformities in most affected joints, and fiber is tetanic, and activity is difficult, and X-ray film shows that joint is seriously broken Bad, dislocation or fusion.

(2) tcm diagnosis standard:

1, main clinical manifestation: the positions pain such as joint, skin, muscles and bones or swelling morning stiffness, numbness weigh, joint stuffiness,

Even joint swelling deformation, it is tetanic do not stretch, muscular atrophy etc..

2, characteristics of incidence: mostly related with climate change.

3, gender, Age Characteristics: person between twenty and fifty are apt to occur in, female is more than male.

4, physico-chemical examination: rheumatoid factor positive or erythrocyte sedimentation rate are speeded, the visible bone erosion of x-ray.

Have above-mentioned 1,4 two, can be made a definite diagnosis in conjunction with 2 or 3.

(3) treatment method: 146 patients stop using other all drugs, all using the pure of the embodiment of the present invention 1 Traditional Chinese medicinal liquor, adult oral medicinal liquor are three times a day taken after meal or in meal, each taking can according to mild symptoms, again take 15~ 25 milliliters；Patient with severe symptoms can appropriate dosage, but may not exceed 35 milliliters every time.Plain boiled water takes, 30 days as one therapeutic course, because It is chronic disease medication, general 3~6 courses for the treatment of are cured.

Note: 1, avoiding eating strong tea, mung bean (mung bean sprouts), seafood food, raw food and pungent stimulation food during treating.

2, there is pain in affected part even the pain increased is normal reaction during treating, and can take somedon, but liquid medicine in short term It cannot withdraw.Pain aggravates phenomenon after individual rheumatoid arthritis patients will appear medication, this is because under drug effect, Impaired diseased region occluded blood vessel is dredged, restoration of blood flow causes hydrops articuli to increase, and joint cavity pressure increases, due to Damaged joints chamber lesion is heavier, cannot as natural joint timely penetrating hydrops, add whithin a period of time to pain occur The phenomenon of weight.Continuing to take rear pain will mitigate, and gradually rehabilitation.

Although 3, not finding serious toxic side effect in clinical observation, which has significant individual difference, dosage It is incremental since low dose of, gradually increase dosage.Secondly, the medicine has certain toxicity, it is necessary to tight under the guidance of doctor Lattice grasp indication, and pregnant woman, children, hypertension, heart disease, chronic ulcer disease, hepatic and kidney function obstacle person avoid clothes, driver and height Idle job personnel, the careful clothes of sportsman.

(4) efficacy assessment standard:

(being drafted referring to " in cure the desease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine 1994 implements as follows :)

1, " healing ": Clinical symptom and sign disappears, and restores normal.(tcm clinical practice symptom, sign disappear or mostly disappear；)

2, " effective ": Clinical symptom and sign substantially or mostly disappears.(tcm clinical practice symptom, sign are substantially change；)

3, " effective ": clinical symptoms are clearly better.(tcm clinical practice symptom, sign take a favorable turn；)

4, engineering noise: Clinical symptom and sign is without improvement.(tcm clinical practice symptom, sign are not improved.)

(5) therapeutic effect:

Clinical cure 33, account for 22%；Effective 33, account for 22%；Effective 73, account for 50%；Invalid 7, total effective rate 94%.

(6) conclusion:

It with Radix Aconiti is monarch, dispelling wind and eliminating dampness, eliminating cold to stop pain in we in terms of theory of traditional Chinese medical science；Radix Aconiti Kusnezoffii, energy dispelling cold and dehumidification, Wen Jing, swelling and pain relieving are ministerial drug, with monarch drug in a prescription Xiang Wuke dispelling cold and removing dampness, current channels and collaterals；Raw dark plum, which promotes the production of body fluid, holds back liquid, opens middle residence and closes, temperature Strongly fragrant mechanism of qi is for adjutant；Licorice coordinating the drug actions of a prescription is to make.There is all medicine compatibility strengthening vital QI to eliminate pathogenic factors in formula dispelling wind and eliminating dampness, dredging collateral to stop Bitterly, the effect of promoting blood circulation to remove blood stasis.By the reasonable compatibility and unique manufacturing process of above-mentioned medicinal material, sufficiently by ingredients Effective component is coordinated to get up after extracting, and is allowed to the efficacy of a drug and plays the best use, and has reached best effects.

The liquid medicine is to rheumatic arthritis, rheumatoid arthritis, sciatica, scapulohumeral periarthritis, cervical spondylosis, lumber ertebral disc Herniation, hemiplegia, various pain chronic diseases etc. are because having unique curative effect caused by wind, cold, wet heresy.

As needed, during medication, acupuncture, lancing can be cooperated, some other method synergistic treatment such as cupping is treated to improve Effect.Acupuncture cupping can make pars affecta skin mucous membrane congested, and pore expansion keeps effective ingredient fully penetrated to lesion Position, acupuncture cupping and Chinese medicine, which act synergistically, can accelerate blood and lymph circulation, warm promoting blood circulation, activating microcirculation and removing stasis medicinal, and surname dissipate chill disappears Curing rheumatism numbness poison, reduces intraosseous pressure, removes the metabolite of stasis of blood product, reaches the stagnant qi and blood of the dredging the channel stasis of blood, relieve pain and Swelling improves the purpose of function of joint.

(7) typical case

Case 1: Wang XX, male, 42 years old, peasant, unity team, the village Wang Yuan, the township Lujiang County great Hua, nineteen ninety-five first visit on November 15, Patient last year lunar calendar starts pain November, and right leg is radiated to always shank external malleolus top from waist breech presentation, and pain is like electric spark Sample, afternoon the pain of clock more than 4 points very, i.e. not bitterly, present left hunkers starts pain, lunar calendar in this year exacerbation of symptoms in June, on foot for sleep It wants to have a rest when walking, calf feels like jelly, and cannot work always after being ill, and weight bearing is that waist is soft；Sleep in readme 30 years old or so feels that finger is numb (in addition to thumb) has duodenal ulcer disease history (being cured)；Through Lujiang county people's hospital CT examination (CT film number: 0005022), Conclusion are as follows: L4~5, L5~S1 protrusion of the intervertebral disc are diagnosed as the protrasion of the lumbar intervertebral disci, take liquid medicine of the present invention and (deactivate other Any drug), three times a day, 20 grams every time, 3 course for the treatment of recoveries from illness is treated, are not recurred within follow-up 10 years.

Case 2: Wang xx, male, 29 years old, peasant, nine village Hu Chong, maple village of Zongyang County kylin town, the first visit on the 23rd of August in 1996, trouble The major Minor articulus of person swells and ache 3~4 years, is very that rainy days, pain added very, and right elbow cannot be bent with elbow joint, articulations digitorum manus, ankle-joint And swell and ache, sublingual venation block is serious, yellow and greasy fur, thready rapid pulse, through An Yifu institute inspection record: rheumatoid factor (RF) is positive, It is diagnosed as rheumatoid arthritis, takes liquid medicine of the present invention (deactivating other any drugs), three times a day, 25 grams every time, treats 4 The course for the treatment of is almost recovered, and does not recur within follow-up 5 years.

Case 3: Wu xx, male, 57 years old, peasant, the village Dou Gang, the township Lujiang County great Hua, first visit on May 9 in 1997, patient pain There is 5~6 years history, starts right leg outer side and ache (from right stern to right external malleolus on the outside of right knee), it is swollen to start acid with rear waist center Bitterly, back and Muscular stiffness are then radiated to, left arm starts to ache within 96 years, meet it is warm then relaxes, stretch, curved backward feel on present left arm Painstakingly, be unable to normal extension, both shoulders distending pain meets exacerbation of symptoms rainy days, modern right leg knee joint distending pain, when walking pain very, right toe Lower cold water feels numb, and two upper limb numbness, back is tied Si Okinawa, the micro- yellow greasy of tongue fur, and side point is red.Physical examination: blood pressure (BP) 100/60mmHg, 64 beats/min of heart rate, left shoulder raises 90 °, cannot protract and back, is diagnosed as right lower extremity sciatica with left side scapulohumeral periarthritis, Liquid medicine of the present invention (deactivating other any drugs) is taken, three times a day, 20 grams every time, treats the recovery from illness of 3 courses for the treatment of, follow-up 10 years is not Recurrence.

Case 4: Xu xx, male, 39 years old, peasant, the town Lujiang County Bai Shan flagpole village, patient came here on May 10th, 2004 Medical, double lower limb knee joint is ached the more than ten years, now develops big Minor articulus all pains, articulations digitorum manus is micro- swollen, adds rainy days very, yellow tongue fur is white Greasy, deeptensepulse number, sublingual extravasated blood weight, Chaohu hospital assay shows: rheumatoid factor (RF) is positive, erythrocyte sedimentation rate (ESR) 4mm/h, resists " o " (ASO) 625 unit is diagnosed as rheumatoid arthritis, takes liquid medicine of the present invention (deactivating other any drugs), three times a day, often It secondary 25 grams, treats 3 course for the treatment of symptom and signs and disappears substantially, do not recur within follow-up 2 years.

Case 5: beam xx, female, 66 years old, peasant, people from Feidong County, 22 Nikkei was cured patient and was introduced and come here December in 2009 Medical, the left gonalgia of readme 8 years starts left knee joint and aches, and develops into needle pricked distending pain within nearly 2~3 years, adds rainy days Weight, double lower toes joint acid distending pains about 3~4, both hands articulations digitorum manus distending pain over nearly 1 year, receive can, two is just normal, and pain in the loins has received wound, Now slight uncomfortable, without " diabetes, hypertension, History of Coronary Heart Disease ", whitish tongue is greasy, deeptensepulse number.Physical examination: (blood pressure) Bp130/70mmHg, It is refreshing clear, ordinary circumstance can, answer freely, left knee joint mild swelling, deformity, tenderness (+) on the inside of knee joint, left side walking now It is unfavorable, skidding paces.Feidong San Yuan x-ray diagnosis on the 5th of August in 2009 are as follows: senile gonitis is taken liquid medicine of the present invention and (stopped With other any drugs), three times a day, 15 grams every time, symptom and sign disappears substantially after treating 3 courses for the treatment of, finds no malicious pair Effect, does not recur for follow-up 6 years.

Case 6: Wu xx, male, 38 years old, peasant, the old team of Lujiang County happy bridge zone great Hua township Wu, first visit on November 7 in 2012, a left side Lower limb distending pain about one year, the short time walked freely, it is long to be unable to travel time, cannot bear a heavy burden, and rainy days, aggravation, there is pain history (7 ~8 years), the greasy micro- Huang of whitish tongue, deeptensepulse lifts leg test (+), is diagnosed as rheumathritis, takes liquid medicine of the present invention and (deactivate other What drug), three times a day, 20 grams every time, 2 course for the treatment of symptom and signs all disappear, and find no any toxic side effect.

Specific embodiment

Embodiment 1: liquid medicine

By weight, 10 parts of Radix Aconiti are taken, 10 parts of Radix Aconiti Kusnezoffii, 10 parts of raw dark plum, 5 parts of licorice, 1 part of white granulated sugar, 50~ 65 degree 1000 parts of white wine.Each bulk pharmaceutical chemicals and white wine are weighed by the parts by weight, it is spare.Chinese herbal medicine is picked into impurity, is cleaned, is added 50~65 degree of white wine, sealing are impregnated 15~30 days, and white granulated sugar is added in the filter and remove residue when color of medical fluid is in dark red, filtrate, It bottles spare, liquid medicine is made.It is oral to drink, 3 times a day, 20~30ml every time, 30 days courses for the treatment of,

Embodiment 2: oral solution

By weight, 15 parts of Radix Aconiti are taken, 15 parts of Radix Aconiti Kusnezoffii, 20 parts of raw dark plum, 10 parts of licorice, 5 parts of white granulated sugar.Except white Outside granulated sugar, each starting material with water of the invention is decocted 1~4 time, preferably 2~3 times, filter and remove residue, filtrate is added white granulated sugar and is made The oral solution of 100 parts of preparation units.

Embodiment 3: capsule

By weight, 20 parts of Radix Aconiti are taken, 20 parts of Radix Aconiti Kusnezoffii, 15 parts of raw dark plum, 15 parts of licorice, 5 parts of white granulated sugar.It incite somebody to action this Each raw material of invention is ground, and is mixed, and is packed into capsule, the capsule of 100 parts of preparation units is made.

Embodiment 4: condensed pill

By weight, 25 parts of Radix Aconiti are taken, 25 parts of Radix Aconiti Kusnezoffii, 30 parts of raw dark plum, 20 parts of licorice, 10 parts of white granulated sugar.It removes Outside white granulated sugar, each starting material with water of the invention is extracted 2~3 times, filtrate alcohol precipitation after filtering, filtrate is concentrated under reduced pressure again, drying, powder White granulated sugar powder is added after broken, 100 portions of preparation unit condensed pills are made.

The above, only presently preferred embodiments of the present invention, are not intended to limit the present invention in any form.It is all The those of ordinary skill of the industry can implement the present invention by the above and swimmingly；But all technologies for being familiar with this profession Personnel without departing from the scope of the present invention, a little change made using disclosed above technology contents/ Modification and the equivalent variations developed, are equivalent embodiment of the invention；Meanwhile all substantial technologicals according to the present invention are to above Change/modification and differentiation of any equivalent variations made by embodiment etc., still fall within the protection model of technical solution of the present invention Within enclosing.

Claims (10)

1. a kind of drug for treating arthralgia due to wind-cold-dampness disease, active pharmaceutical ingredient is by monkshood, radix aconiti agrestis, dark plum, Radix Glycyrrhizae and white sugar group At.

2. drug according to claim 1, wherein calculating by weight, 5-35 parts of monkshood, 5-40 parts of radix aconiti agrestis, dark plum 10- 35 parts, 1-20 parts of Radix Glycyrrhizae and 1-10 parts of white sugar.

3. drug according to claim 2, wherein calculating by weight, 5-20 parts of monkshood, 5-25 parts of radix aconiti agrestis, dark plum 10- 20 parts, 1-10 parts of Radix Glycyrrhizae and 1-5 parts of white sugar；Or it calculates by weight, 20-35 parts of monkshood, 25-40 parts of radix aconiti agrestis, dark plum 20-35 Part, 10-20 parts of Radix Glycyrrhizae and 5-10 parts of white sugar.

4. drug according to claim 1 to 3, wherein monkshood, radix aconiti agrestis, dark plum and/or the Radix Glycyrrhizae are health product or big gun Product；Preferably health product.

5. drug described in -4 according to claim 1, monkshood, radix aconiti agrestis, vomiting nut, dark plum and/or Radix Glycyrrhizae therein are crude drug Original powder, or it is extracted for crude drug and/or separate extract obtained.

6. drug described in -5 according to claim 1 is liquid preparation or solid pharmaceutical preparation；Preferably, the drug is medicine Wine, syrup, oral solution, capsule, tablet, pill, condensed pill, granule, paste, applicator, sustained release or controlled release agent.

7. drug described in claim 1-6 is applied in preparing the drug for treating arthralgia due to wind-cold-dampness disease.

8. application according to claim 7, the drug is used for dispelling cold and dehumidification, searches wind and removing obstruction in channels, activating microcirculation and removing stasis medicinal or temperature Meridian and relieving pain.

9. the drug is for treating rheumatic arthritis, rheumatoid joint according to application described in claim 7-8 Intractable rheumatism bone disease caused by inflammation, cervical spondylosis, scapulohumeral periarthritis, sciatica, the protrasion of the lumbar intervertebral disci or a variety of causes.

10. application according to claim 9, wherein the drug is closed for treating rheumatic arthritis or rheumatoid Section is scorching.