CN110013517A - A kind of summer oyster gold that treating lung cancer disappears formula and preparation method thereof - Google Patents

A kind of summer oyster gold that treating lung cancer disappears formula and preparation method thereof Download PDF

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CN110013517A
CN110013517A CN201910369514.7A CN201910369514A CN110013517A CN 110013517 A CN110013517 A CN 110013517A CN 201910369514 A CN201910369514 A CN 201910369514A CN 110013517 A CN110013517 A CN 110013517A
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parts
gold
lung cancer
oyster
preparation
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CN110013517B (en
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范焕芳
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HEBEI PROV TRADITIONAL CHINESE MEDICINE HOSPITAL
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HEBEI PROV TRADITIONAL CHINESE MEDICINE HOSPITAL
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    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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Abstract

The invention belongs to technical field of traditional Chinese medicines, proposes a kind of summer oyster gold for treating lung cancer and disappear formula and preparation method thereof.A kind of summer oyster gold that treating lung cancer disappears formula, it is grouped as by the group of following parts by weight: 6~10 parts of prepared RHIZOMA PINELLIZE without adju-vant, 3~7 parts of bulbus fritillariae cirrhosae, 9~12 parts of dried orange peel, 23~35 parts of oyster, 10~23 parts of Poria cocos, 10~15 parts of salvia chinensis, 15~25 parts of Radix Astragali, 8~15 parts of the root of straight ladybell, 7~10 parts of Radix Angelicae Sinensis, 8~13 parts of sweet aster, 8~13 parts of sweet tussilago, 26~33 parts of radix ranunculi ternati, 2~5 parts of licorice, preparation method first individually impregnates sweet aster and sweet tussilago, water extracts after mixing again with other traditional Chinese medicinal components after lixivium is removed, alcohol precipitation after concentration, spray drying obtains dried cream powder, dextrin is added to dried cream powder, it pelletizes after mixing, instill ethanol wet agent, it is sieved after mixing, it is dry, a kind of summer oyster gold for treating lung cancer is obtained to disappear particle.Through the above technical solutions, solve the problems, such as to treat in the prior art lung cancer Chinese materia medica preparation raw material type is more, high production cost.

Description

A kind of summer oyster gold that treating lung cancer disappears formula and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines, it is related to a kind of summer oyster gold for treating lung cancer and disappears formula and preparation method thereof.
Background technique
Lung cancer is the abbreviation of " primary bronchogenic carcinoma of lung ", be global incidence and the highest malignant tumour of the death rate it One, it is counted according to the World Health Organization (WHO), the annual new discovery patients with lung cancer in the whole world is more than 1,200,000, and cumulative year after year is presented and becomes Gesture.China due to aging of population rapid aggravation, the industrialization of economic rapid growth bring, urbanization process high speed development Caused by environment high progression and tobacco control is ineffective causes smoking rate high, the disease incidence of lung cancer increases year by year.How 5 years survival rates of lung cancer are improved, patients ' life quality is improved, as early as possible reduce the lung cancer morbidity rate increasingly risen, the death rate, at For the hot subject of current medical field research.As new chemotherapeutics, three-dimensional conformal radiotherapy, molecular targeted agents face Bed application, the treatment level of lung cancer has to be improved to a certain degree, but the corresponding adverse reaction generated is also with increase.
There are many distinctive features for traditional Chinese medicine treating cancer, are increasingly becoming one of the important means of complex treatment.5th state Traditional Chinese medicine and operation, radiotherapy, chemotherapy, biotherapy have been listed as five big means of current anti-curing cancers by border cancer conference. Therefore, seek the traditional Chinese medicine effectively having no toxic side effect treatment as far as possible to be of great significance.Publication No. CN103623349A Application for a patent for invention disclose a kind of lung cancer drug, the bulk pharmaceutical chemicals are by 6 parts of edible tulip, 4 parts of vomiting nut, 0.3 part of Chinese blister beetle, nidus vespae 20 parts, 40 parts of black nightshade, 60 parts of Sculellaria barbata, 20 parts of 60 part, day fourth of oldenlandia diffusa, 30 parts of viola mandshurica, 30 parts of Honeysuckle bine, company Stick up 20 parts, 30 parts of Radix Isatidis, 30 parts of radix paeoniae rubra, 20 parts of trigone, 30 parts of curcuma zedoary, 20 parts of turmeric, 60 parts of paniculate swallowwort, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 0.08 part, 20 parts of ground bettle, 30 parts of seaweed, 30 parts of thallus laminariae, 20 parts of fritillaria thunbergii, 20 parts of olibanum, 20 parts of myrrh, 20 parts of radix bupleuri, trifoliate orange 20 parts of shell, 20 parts of Radix Paeoniae Alba, 20 parts of Rhizoma Chuanxiong, 20 parts of rhizoma cyperi, 20 parts of the tuber of pinellia, 30 parts of oyster, 20 parts of Rhizoma Atractylodis Macrocephalae, six bent 20 parts, hawthorn 20 Part, 20 parts of coloured malt, 20 parts of ginseng, 20 parts of Radix Astragali, 30 parts of radix rehmanniae preparata, 20 parts of Semen Cuscutae, 20 parts of Herba Epimedii, 20 parts of the tuber of multiflower knotweed are by weight Than composition, except edible tulip, vomiting nut, Chinese blister beetle, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) break into altogether fine powder be packed into capsule in addition to, remaining drug decocting to obtain the final product, Raw material pharmacopoeia class is various in the formula of Chinese materia medica preparation, high production cost.
Summary of the invention
The present invention propose a kind of summer oyster gold for treating lung cancer disappear formula and preparation method thereof, solve and treat in the prior art The problem of Chinese materia medica preparation raw material type of lung cancer is more, high production cost.
The technical scheme of the present invention is realized as follows:
A kind of summer oyster gold that treating lung cancer disappears formula, is grouped as by the group of following parts by weight:
6~10 parts of prepared RHIZOMA PINELLIZE without adju-vant, 3~7 parts of bulbus fritillariae cirrhosae, 9~12 parts of dried orange peel, 23~35 parts of oyster, 10~23 parts of Poria cocos, stone is shown in Wear 10~15 parts, 15~25 parts of Radix Astragali, 8~15 parts of the root of straight ladybell, 7~10 parts of Radix Angelicae Sinensis, 8~13 parts of sweet aster, sweet tussilago 8~13 Part, 26~33 parts of radix ranunculi ternati, 2~5 parts of licorice.
As further technical solution, it is grouped as by the group of following parts by weight:
It is 8 parts of prepared RHIZOMA PINELLIZE without adju-vant, 5 parts of bulbus fritillariae cirrhosae, 11 parts of dried orange peel, 28 parts of oyster, 17 parts of Poria cocos, 13 parts of salvia chinensis, 20 parts of Radix Astragali, husky 12 parts of ginseng, 8 parts of Radix Angelicae Sinensis, 10 parts of sweet aster, 10 parts of sweet tussilago, 29 parts of radix ranunculi ternati, 4 parts of licorice.
The invention also provides a kind of summer oyster gold for treating lung cancer disappears the preparation method of particle, comprising the following steps:
S1. disappear formula according to above-mentioned summer oyster gold, it is spare to weigh each component；
S2. by prepared RHIZOMA PINELLIZE without adju-vant, bulbus fritillariae cirrhosae, dried orange peel, oyster, Poria cocos, salvia chinensis, Radix Astragali, the root of straight ladybell, Radix Angelicae Sinensis, radix ranunculi ternati, licorice It soaks in water, obtains wet medicinal material group one；
S3. sweet aster, sweet tussilago are soaked in water, obtains wet medicinal material group two；
S4. it is mixed after the lixivium of the obtained wet medicinal material group two of step S3 being removed with the obtained wet medicinal material group one of step S2 It closes, obtains mixing wet medicinal material, add water to cook extraction, obtain filtrate；
S5. filtrate concentration, spray drying step S4 obtained, obtains dried cream powder；
S6. dextrin is added in dried cream powder step S5 obtained, pelletizes after mixing, ethanol wet agent is instilled, after mixing Obtain wet granular；
S7. wet granular step S6 obtained is dry, obtains a kind of summer oyster gold for treating lung cancer and disappears particle.
As further technical solution, extraction is added water to cook in step S4 specifically: amount of water is the 6 of wet quality of medicinal material It~10 times, decocts 1~3 time, each decocting time is 1~2 hour.
As further technical solution, extraction is added water to cook in step S4 specifically: amount of water is the 8 of wet quality of medicinal material Times, it decocts 2 times, each decocting time is 1.5 hours.
As further technical solution, stevioside is added when being concentrated in step S5, the stevioside and medicinal material are total The mass ratio of amount is 2:175.
As further technical solution, relative density 1.06~1.20 is concentrated into step S5.
As further technical solution, further includes alcohol precipitation before being spray-dried after step S5 concentration: being added into concentrate It is 55%~65% that 95% ethyl alcohol, which is stirred to concentration of alcohol, stands 24 hours, alcohol precipitation: 95% ethyl alcohol being added into concentrate Stirring to concentration of alcohol is 55%~65%, stands 24 hours, takes supernatant centrifugation, ethyl alcohol is recovered under reduced pressure.
As further technical solution, stirring to concentration of alcohol is 60% in step S5.
As further technical solution, the mass ratio of dried cream powder and dextrin is 1:2, second in ethanol wet agent in step S6 Determining alcohol is 60%.
It the working principle of the invention and has the beneficial effect that
1, in the present invention, summer oyster gold disappears to be formulated to be made of the 13 taste medicine such as prepared RHIZOMA PINELLIZE without adju-vant, bulbus fritillariae cirrhosae, dried orange peel, and raw material is simple and easy to get, It is at low cost, have effects that resolving sputum removing toxic substances, supplementing qi and nourishing yin, is clinically mutually tied for treating acute purulent lymphadenitis, type of deficiency of both QI and YIN lung cancer and curative effect It is good, no recurrence.Using prepared RHIZOMA PINELLIZE without adju-vant, bulbus fritillariae cirrhosae as monarch drug in a prescription in formula, moistening lung for removing phlegm cough-relieving；With dried orange peel, Radix Astragali, the root of straight ladybell, oyster, sand Ginseng, salvia chinensis, radix ranunculi ternati are ministerial drug altogether, the function of existing reducing phlegm and resolving masses removing toxic substances, and have the benefits of supplementing qi and nourishing yin, wherein dried orange peel principal drug assistance Eliminating dampness and eliminating phlegm and regulating qi-flowing for strengthening spleen, Radix Astragali benefiting qi and nourishing blood, the root of straight ladybell nourishiing yin to clear away the lung-heat, reinforcing stomach reg fluid, oyster yin-nourishing checking exuberance of yang, resolving hard lump, Salvia chinensis and radix ranunculi ternati is clearing heat and detoxicating, reducing phlegm and resolving masses；With Radix Angelicae Sinensis, sweet aster, sweet tussilago, Poria cocos altogether for adjutant, Radix Angelicae Sinensis assistant is helped Radix Astragali tonifying Qi and blood, sweet aster and sweet tussilago moistening lung for removing phlegm cough-relieving, Poria cocos spleen-benefiting mind-tranquilizing；It is to make medicine mediation property of medicine with Radix Glycyrrhizae, All medicines share, compatibility is reasonable, up to the effect of resolving sputum removing toxic substances, supplementing qi and nourishing yin.
2, summer oyster gold prepared by the present invention disappears, and content of hesperidin in particle is high, and aurantiamarin can induce or promote non-small cell Lung cancer A549/DDP Apoptosis influences the synthesis of lung carcinoma cell albumen by interference PI3K-Akt signal path, to embody Its apparent anti-tumor activity, clinical treatment show that summer oyster gold prepared by the present invention disappears particle good effect, quick, takes safety Reliably, the deficiency for compensating for existing treatment technology plays good therapeutic effect.
3, in the present invention, first sweet aster and sweet tussilago are individually impregnated in preparation method, after lixivium is removed again with Alcohol precipitation, spray drying, wet granulation etc., can be effectively reduced the glutinous of particle after water is extracted, is concentrated after other traditional Chinese medicinal components mixing Property, so that summer oyster gold disappears, the viscosity of particle is small, and ratio of briquetting is high, plays unexpected effect, efficiently solves granulation The problem that particle stickiness causes greatly ratio of briquetting low in the process, wherein adopt and middle sweet aster is extracted with water and sweet tussilago is individually impregnated Part honey can be made to be dissolved in the water, water removes its lixivium before extracting, and reduces the sugar content of medical fluid after extracting, to reduce particle Stickiness；Alcohol precipitation pure preparations after concentration guarantee its quality and stability, meanwhile, dry spun is suitably reduced, can maintained Medication dose is reduced while active ingredient level；Select dextrin as auxiliary material, by the mass ratio for controlling dried cream powder and dextrin Improve the stickiness of particle；It selects concentration of alcohol for 60% ethanol wet agent, the dried cream powder after spray drying is quickly pelletized, Reduce the stickiness of particle.Preparation method is stable and simple and feasible, and summer oyster gold obtained disappears, and particle is neat, and ratio of briquetting is high, and makes It is convenient to take, quality controllable, suitable to promote the use of at granule.
Detailed description of the invention
The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.
Fig. 1 is that content of hesperidin of the present invention detects liquid chromatogram；
In figure: A- reference substance solution, B- test solution, C- negative control solution, the characteristic peak of peak 1- aurantiamarin.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described, Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all Belong to the scope of protection of the invention.
Embodiment 1
A kind of summer oyster gold that treating lung cancer disappears formula, is grouped as by the group of following weight:
Prepared RHIZOMA PINELLIZE without adju-vant 6g, bulbus fritillariae cirrhosae 3g, dried orange peel 9g, oyster 23g, Poria cocos 10g, salvia chinensis 10g, Radix Astragali 15g, the root of straight ladybell 8g, when Return 7g, sweet aster 8g, sweet tussilago 8g, radix ranunculi ternati 26g, licorice 2g,
Summer oyster gold disappears the preparation method of particle, comprising the following steps:
S1. according to above-mentioned formula, it is spare to weigh each component；
S2. by prepared RHIZOMA PINELLIZE without adju-vant, bulbus fritillariae cirrhosae, dried orange peel, oyster, Poria cocos, salvia chinensis, Radix Astragali, the root of straight ladybell, Radix Angelicae Sinensis, radix ranunculi ternati, licorice The water that its 10 times of quality are added impregnates 2 hours, obtains wet medicinal material group one；
S3. the water that its 10 times of quality are added in sweet aster, sweet tussilago is impregnated 2 hours, obtains wet medicinal material group two；
S4. it is mixed after the lixivium of the obtained wet medicinal material group two of step S3 being removed with the obtained wet medicinal material group one of step S2 It closes, obtains mixing wet medicinal material, add the water boiling and extraction of 8 times of quality 2 hours, decoct and extract 2 times, obtain filtrate；
S5. 2g stevioside is added in the filtrate obtained to step S4, relative density 1.11~1.15 is concentrated into, to concentration The ethyl alcohol of addition 95%, which is stirred to concentration of alcohol, in liquid is 60% standing 24 hours, takes supernatant to be centrifuged, then reduced-pressure backflow returns Ethyl alcohol is received, last concentrated spray is dry, obtains dried cream powder；
S6. the mass ratio of dried cream powder addition dextrin step S5 obtained, dried cream powder and dextrin is 1:2, after mixing Granulation instills the ethanol wet agent that concentration is 60%, with the hands mixes, do not stop to frustrate and pinch, control dynamics according to feel, avoid The residence time is too long and form hard sphere in palm, be finally reached uniform wet and can " hold agglomerating, touching dissipate ", be then placed in In 16 meshes, the even power of palm makes softwood by sieve pore, obtains wet granular to being pushed forward；
S7. wet granular step S6 obtained is dry, obtains a kind of summer oyster gold for treating lung cancer and disappears particle.
Embodiment 2
A kind of summer oyster gold that treating lung cancer disappears formula, is grouped as by the group of following parts by weight:
Prepared RHIZOMA PINELLIZE without adju-vant 8g, bulbus fritillariae cirrhosae 5g, dried orange peel 11g, oyster 28g, Poria cocos 17g, salvia chinensis 13g, Radix Astragali 20g, the root of straight ladybell 12g, Radix Angelicae Sinensis 8g, sweet aster 10g, sweet tussilago 10g, radix ranunculi ternati 29g, licorice 4g,
Preparation method is the same as embodiment 1.
Embodiment 3
A kind of summer oyster gold that treating lung cancer disappears formula, is grouped as by the group of following parts by weight:
Prepared RHIZOMA PINELLIZE without adju-vant 10g, bulbus fritillariae cirrhosae 7g, dried orange peel 12g, oyster 35g, Poria cocos 23g, salvia chinensis 15g, Radix Astragali 25g, the root of straight ladybell 15g, Radix Angelicae Sinensis 10g, sweet aster 13g, sweet tussilago 13g, radix ranunculi ternati 33g, licorice 5g,
Preparation method is the same as embodiment 1.
Embodiment 4
A kind of summer oyster gold that treating lung cancer disappear formula formula with embodiment 2,
Extraction is added water to cook in preparation method in step S4 specifically: amount of water is 6 times of wet quality of medicinal material, decocts 3 Secondary, each decocting time is 2 hours, remaining preparation step is the same as embodiment 1.
Embodiment 5
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
Extraction is added water to cook in preparation method in step S4 specifically: amount of water is 10 times of wet quality of medicinal material, decocts 1 Secondary, each decocting time is 1.5 hours, remaining preparation step is the same as embodiment 1.
Embodiment 6
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
Extraction is added water to cook in preparation method in step S4 specifically: amount of water is 10 times of wet quality of medicinal material, decocts 3 Secondary, each decocting time is 1 hour, remaining preparation step is the same as embodiment 1.
Embodiment 7
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
Extraction is added water to cook in preparation method in step S4 specifically: amount of water is 8 times of wet quality of medicinal material, decocts 1 Secondary, each decocting time is 2 hours, remaining preparation step is the same as embodiment 1.
Embodiment 8
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
Extraction is added water to cook in preparation method in step S4 specifically: amount of water is 10 times of wet quality of medicinal material, decocts 2 Secondary, each decocting time is 2 hours, remaining preparation step is the same as embodiment 1.
Embodiment 9
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
Extraction is added water to cook in preparation method in step S4 specifically: amount of water is 8 times of wet quality of medicinal material, decocts 3 Secondary, each decocting time is 1.5 hours, remaining preparation step is the same as embodiment 1.
Embodiment 10
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
Extraction is added water to cook in preparation method in step S4 specifically: amount of water is 6 times of wet quality of medicinal material, decocts 2 Secondary, each decocting time is 1.5 hours, remaining preparation step is the same as embodiment 1.
Embodiment 11
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
Extraction is added water to cook in preparation method in step S4 specifically: amount of water is 8 times of wet quality of medicinal material, decocts 2 Secondary, each decocting time is 1 hour, remaining preparation step is the same as embodiment 1.
Embodiment 12
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
Extraction is added water to cook in preparation method in step S4 specifically: amount of water is 6 times of wet quality of medicinal material, decocts 1 Secondary, each decocting time is 1 hour, remaining preparation step is the same as embodiment 1.
Embodiment 13
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
It is corresponding in preparation method to be changed to step S5: 2g stevioside is added in the filtrate obtained to step S4, it is dense It is reduced to relative density 1.06~1.10, it is that 60% standing 24 is small that the ethyl alcohol of addition 95%, which is stirred to concentration of alcohol, into concentrate When, it takes supernatant concentrated spray dry, before spray drying, ethyl alcohol is recovered under reduced pressure after being first centrifuged supernatant, remaining preparation step With embodiment 1.
Embodiment 14
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
It is corresponding in preparation method to be changed to step S5: 2g stevioside is added in the filtrate obtained to step S4, it is dense It is reduced to relative density 1.16~1.20, it is that 60% standing 24 is small that the ethyl alcohol of addition 95%, which is stirred to concentration of alcohol, into concentrate When, take supernatant to be centrifuged, then reduced-pressure backflow recycles ethyl alcohol, and last concentrated spray is dry, obtains dried cream powder, remaining preparation step With embodiment 1.
Embodiment 15
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
Preparation method is corresponding to be changed to step S5: 2g stevioside, concentration being added in the filtrate obtained to step S4 To relative density 1.11~1.15, into concentrate, the ethyl alcohol of addition 95%, which is stirred to concentration of alcohol, is 55% standing 24 hours, Supernatant is taken to be centrifuged, then reduced-pressure backflow recycles ethyl alcohol, and last concentrated spray is dry, obtains dried cream powder, remaining preparation step is same Embodiment 1.
Embodiment 16
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
It is corresponding in preparation method to be changed to step S5: 2g stevioside is added in the filtrate obtained to step S4, it is dense It is reduced to relative density 1.11~1.15, it is that 65% standing 24 is small that the ethyl alcohol of addition 95%, which is stirred to concentration of alcohol, into concentrate When, take supernatant to be centrifuged, then reduced-pressure backflow recycles ethyl alcohol, and last concentrated spray is dry, obtains dried cream powder, remaining preparation step With embodiment 1.
Comparative example 1
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
It is corresponding in preparation method that the mass ratio of dried cream powder and dextrin in step S6 is changed to 1:1, remaining preparation step With embodiment 1.
Comparative example 2
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
It is corresponding in preparation method that the mass ratio of dried cream powder and dextrin in step S6 is changed to 1:1.5, remaining preparation step Suddenly with embodiment 1.
Comparative example 3
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
Corresponding in preparation method that concentration of alcohol in step S6 is changed to 40%, remaining preparation step is the same as embodiment 1.
Comparative example 4
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
Corresponding in preparation method that concentration of alcohol in step S6 is changed to 80%, remaining preparation step is the same as embodiment 1.
Comparative example 5
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
Preparation method are as follows:
S1. according to above-mentioned formula, it is spare to weigh each component；
S2. prepared RHIZOMA PINELLIZE without adju-vant, bulbus fritillariae cirrhosae, dried orange peel, oyster, Poria cocos, salvia chinensis, Radix Astragali, the root of straight ladybell, Radix Angelicae Sinensis, radix ranunculi ternati, life is sweet The water that its 10 times of quality are added in grass, sweet aster, sweet tussilago impregnates 2 hours, obtains mixing wet medicinal material；
S3. it in the wet medicinal material of mixing step S2 obtained plus water boiling and extraction 1.5 hours of 8 times of quality, decocts and extracts 2 It is secondary, obtain filtrate；
S5. 2g stevioside is added in the filtrate obtained to step S4, relative density 1.11~1.15 is concentrated into, to concentration The ethyl alcohol of addition 95%, which is stirred to concentration of alcohol, in liquid is 60% standing 24 hours, takes supernatant to be centrifuged, then reduced-pressure backflow returns Ethyl alcohol is received, last concentrated spray is dry, obtains dried cream powder；
S6. the mass ratio of the dried cream powder addition dextrin obtained to step S5, dried cream powder and dextrin is 1:2, after mixing Granulation instills the ethanol wet agent that concentration is 60%, with the hands mixes, do not stop to frustrate and pinch, control dynamics according to feel, avoid The residence time is too long and form hard sphere in palm, be finally reached uniform wet and can " hold agglomerating, touching dissipate ", be then placed in In 16 meshes, the even power of palm makes softwood by sieve pore, obtains wet granular to being pushed forward；
S7. wet granular step S6 obtained is dry, obtains a kind of summer oyster gold for treating lung cancer and disappears particle.
Comparative example 6
A kind of summer oyster gold that treating lung cancer disappears formula with embodiment 2,
Corresponding in preparation method that dextrin in step S6 is changed to prepared RHIZOMA PINELLIZE without adju-vant and bulbus fritillariae cirrhosae, remaining preparation step is the same as implementation Example 1.
In above-described embodiment and comparative example, stevioside buying is produced from Qufu Xiang Zhou stevia rebaudianum product Co., Ltd Licensing number: SC2013708810605.
1, content of hesperidin measures
1. chromatographic condition: chromatographic column: C18 column (5 μm, 4.6 × 200mm)；Mobile phase: -0.1% phosphoric acid of acetonitrile (20%: 80%)；Detection wavelength is 283nm；Number of theoretical plate is calculated by aurantiamarin peak should be not less than 2000；Flow velocity: 1.0ml/min；Column temperature: 25℃；Sample volume: 10 μ l.
2. the preparation of solution: reference substance solution: precision weighs aurantiamarin control sample 1.5mg, is placed in 10ml measuring bottle, adds Methanol constant volume to mass concentration is 0.15mgml-1, it is 5 minutes ultrasonic, cross water filter membrane, wherein the buying of aurantiamarin control sample is certainly Chengdu Inst. of Biology, Chinese Academy of Sciences, lot number: MUST-18032502；Test solution: in embodiment 1~12 in step S4 It mixes wet medicinal material and adds water to cook the filtrate obtained after extraction.
Chromatogram is shown in Fig. 1, and A is reference substance solution in Fig. 1, and B is to mix wet medicine in 2 step S4 of embodiment in test solution Material adds water to cook the filtrate obtained after extraction, and spectrogram and the B of remaining embodiment are not much different, therefore omits, and C is that negative control is molten Liquid, peak 1 are the characteristic peak of aurantiamarin, pass through calculated by peak area content of hesperidin.
2, go out the measurement of dry cream rate:
The dried cream powder weighing that will be obtained after 1~12 step S5 of embodiment spray drying, calculates dry cream rate.
The content of hesperidin that the summer oyster gold of embodiment 1~12 disappears in particulate production is shown in Table 1 with dry cream rate out:
The content of hesperidin that the summer oyster gold of 1 embodiment 1~12 of table disappears in particulate production and dry cream rate out
Group Content of hesperidin/(mgg-1) Dry cream rate/(%) out Comprehensive score
Embodiment 1 35.27 26.35 94.16
Embodiment 2 37.15 26.39 97.38
Embodiment 3 38.31 26.72 99.86
Embodiment 4 36.53 26.25 96.15
Embodiment 5 24.74 23.05 70.11
Embodiment 6 31.37 23.90 84.09
Embodiment 7 26.20 23.21 73.92
Embodiment 8 38.28 26.57 99.70
Embodiment 9 38.32 26.77 100.00
Embodiment 10 33.49 25.48 89.73
Embodiment 11 29.60 24.28 81.28
Embodiment 12 17.59 19.39 54.03
Wherein, aurantiamarin accounts for weight 70% in comprehensive score, and dry cream rate accounts for weight 30% out.
By data in table 1 can be seen that summer oyster gold disappear formula and preparation method water mentions middle amount of water, water mentions number and when Between content of hesperidin and dry cream rate out can all be had an impact, wherein in Examples 1 to 3, the synthesis of the formula of embodiment 2 is commented Point highest, in embodiment 4~12, the preparation method water of embodiment 9 extract in amount of water, the synthesis that water mentions number and the time obtains Score highest, but adds 8 Bei Shui in water extraction and add the score value difference of 10 times of water little, therefore, the preparation method of embodiment 2 During water extracts plus 8 times of water, to decoct 2 times, decoct 2 hours every time be optimised process, out active principle in dry cream rate and extract Content is relatively high, while productivity effect is high.
3 groups of parallel tests are done according to the formula and preparation method of embodiment 2, number 1~3 measures the skin glycosides in extracting solution Content and dry cream rate out, verify the stability of water extraction process, the results are shown in Table 2:
2 water extraction process stability of table
Number Content of hesperidin/(mgg-1) Dry cream rate/(%) out
1 37.63 26.35
2 38.11 25.72
3 37.75 26.16
Average value 37.94 26.08
RSD (%) 0.39 1.2
From upper table data can be seen that according to embodiment 2 water extraction process in triplicate, in resulting extracting solution Effective component aurantiamarin, dry cream rate is close out, illustrates that preparation method stability of the invention is high, operability is good.
The content of hesperidin disappear in particulate production to the summer oyster gold of embodiment 2, embodiment 13~16 and dry cream rate out It is measured according to the method described above, the results are shown in Table 3:
3 embodiment 2 of table, the content of hesperidin that disappears in particulate production of summer oyster gold of embodiment 13~16 and dry cream rate out
Group Content of hesperidin/(mgg-1) Dry cream rate/(%) out
Embodiment 2 18.5 16.5
Embodiment 13 16.7 17.2
Embodiment 14 17.6 15.7
Embodiment 15 18.1 16.8
Embodiment 16 17.6 15.5
As can be seen from the above table, after alcohol precipitation, dry cream rate is down to about 16% out, and the average value 25% after extracting with water compares Compared with mean transferred rate > 60% is concentrated into relative density 1.11~1.15, and alcohol is sink to concentration of alcohol and makes in extract for 60% The content of aurantiamarin is maximum, and effect is best.
In comparative example 2 and 1~2 pelletization of comparative example, grain shape and ratio of briquetting, grain dissolution degree etc., as a result It is shown in Table 4:
4 embodiment 2 of table and the phenomenon in 1~2 pelletization of comparative example
The data comparison of embodiment 2 and comparative example 1~2 can be seen that summer oyster made from the embodiment of the present invention 2 from upper table Gold disappears, and particle viscosity is suitable, and grain dissolution degree is high, and particle is neat, and ratio of briquetting is high, illustrates that the present invention passes through change dried cream powder and paste The mass ratio of essence improves summer oyster gold well and disappears the stickiness of particle, so that the summer oyster gold of preparation disappears, particle easily passes through sieve, Grain is neat, and ratio of briquetting is high.
It can be seen that from the data comparison of embodiment 2 in upper table and comparative example 3~4 and select ethyl alcohol in ethanol wet agent dense Spend the summer oyster gold obtained in 60% and 80% disappear particle viscosity, grain dissolution degree, particle uniformity and ratio of briquetting it is higher, But from drug safety, the alcohol content in medicament should be reduced as far as possible, therefore, ethanol wet agent concentration of the invention It is best to set the resultant effect generated.
Summer oyster gold of the invention disappears particle during the preparation process, using the preparation method of conventional Chinese medicinal granule (see comparative example 6) that, it is found that the particle stickiness of preparation is big, sieve pore is sticked in pelletization, ratio of briquetting is low (being shown in Table 3), this is because the mistake extracted in water Cheng Zhong, polysaccharide and liposoluble substance etc. are dissolved out with effective component, keep medicinal extract stickiness excessive, so that ratio of briquetting is low, due in Medicine original powder stickiness is relatively small, in order to reduce particle stickiness, attempts the biggish bulbus fritillariae cirrhosae of mealiness and prepared RHIZOMA PINELLIZE without adju-vant to be crushed to selection Drugloading rate (see comparative example 5) is improved instead of dextrin, the results are shown in Table 3, illustrates that the stickiness of particle can not be effectively reduced in this method, And in the present invention, select dextrin to be used as auxiliary material, first individually impregnate sweet aster and honey tussilago in preparation method, then again with its Alcohol precipitation, spray drying, wet granulation etc., can be effectively reduced the stickiness of particle after water is extracted, is concentrated after the mixing of its traditional Chinese medicinal components, So that summer oyster gold disappears, the viscosity of particle is small, and ratio of briquetting is high, plays unexpected effect.
Summer oyster gold prepared by the embodiment of the present invention 2 particle that disappears is used for the treatment of lung cancer, clinical treatment situation is as follows:
General information: in January, 2017~2019 year accept for medical treatment altogether December lung cancer disease type belong to acute purulent lymphadenitis mutually tie, type of deficiency of both QI and YIN Patient 170, wherein male 110, women 60, the age 35~90 years old, average age 63 years old.
Treatment method: it gives the summer oyster gold particles with water that disappears and takes after mixing it with water oral, each 15g, 3 times a day, 2 months are 1 course for the treatment of. Curative effect is judged after 3 courses for the treatment of.
Curative effect judging standard:
(1) tcm syndrome deliberated index: tcm symptom according to clinical observation be divided into 4 grades: 0 grades it is asymptomatic；1 grade slight；2 grades Moderate；3 grades of severes.The case where treatment condition occurs according to symptom record.Effective: symptom disappears or symptom integral reduces >=2/ 3；Effective: symptom mitigates, and integral reduces >=1/3, < 2/3；It is invalid: even symptom reduces < 1/3 without exacerbation, integral is mitigated.
(2) it life quality scores standard: is evaluated by the score of Cattell standards of grading, score increases >=10 points of persons after treatment To improve,<10 points of persons are increased or decreased to stablize, reducing by>=10 points of persons is decline.
Adverse reaction: without obvious adverse reaction.
Treatment results: the treatment through 3 courses for the treatment of effective 46, invalid 18, always has effective 106 in 170 patients Efficiency 89%, it is curative for effect, do not occur malaise symptoms in therapeutic process.
Concrete case is as follows:
Case 1: Zhao so-and-so, male, it is 54 years old, married, in first visit on April 11 in 2017, because cough occurs in flu before readme 2 weeks Cough, pectoralgia, cannot alleviate, look into chest CT and show: 1, simultaneously double lungs are multiple for upper lobe of left lung peripheral type carcinoma of lung (size about 9.0 × 6.4cm) Transfer；2, left pulmonary branches tracheaectasy and upper lobe of left lung capillary bronchitis；3, the multiple larger lymph node of diaphragm is indulged.Pathology shows: adenocarcinoma of lung. It is diagnosed as left malignant tumor of lung.Patient's row PL scheme chemotherapy, still there is cough, expectoration, pectoralgia symptom, takes summer oyster gold and disappears particle four After a month, cough mitigates, and expectoration amount is few, and pectoralgia symptom is substantially reduced, continues to take to 8 months, and above-mentioned symptom controls substantially, Continue to take to consolidate curative effect, follow-up on May 26 is without recurrence within 2018.
Case 2: Ren, female is 58 years old, married, and in the first visit on the 18th of September in 2017, appearance cough, cough are white before readme 3 years Phlegm is interrupted oral pectoral and does not improve.Cough in 2017, expectoration aggravate, and shortness of breath is obvious after activity, the visible right side thoracic cavity product of CT The multiple metastatic tumor of liquid, lung, row lung puncture cytology pathology: visible heterocyst, not except cancer cell.Histology pathology: Fu Bi Shape cell (mucus type).Diagnosis are as follows: malignant tumor of lung.It takes summer oyster gold to disappear after particle January, cough and expectoration, shortness of breath symptom are obvious Improve, continues to take summer oyster gold and disappear particle to consolidate curative effect, follow-up symptom control in 2 months 2018 is good.
Case 3: it is huge so-and-so, female is 54 years old, married, in first visit on January 10 in 2018, occur readme in May, 2016 cough, The white phlegm of cough, shortness of breath, the cough suppressing medicines such as interruption oral " methoxyphenamini hydrochloridum ", which have no, to be clearly better.In November, 2017 looks into chest CT: right lung door And inferior lobe of right lung soft tissue tumors, inferior lobe of right lung obliterative inflammation, consider that centrality lung cancer possibility is big.Pathology: cellule lung Cancer.Diagnosis are as follows: the obstructive lung cancer of right lung small cell carcinoma right lung.It takes summer oyster gold to disappear after particle January, patient is interrupted cough, expectoration Amount is reduced, and without obvious shortness of breath, continues to take to 3 months, and patient's above-mentioned symptom improves substantially, continues to take the present invention to consolidate treatment Effect, follow-up symptom is without repeatedly within 2 months 2019.
Case 4: Mr. Li, male, 58 years old, married, in the first visit on the 19th of September in 2018, readme in March, 2017 is because of cough, cough Phlegm looks into chest CT: a large amount of pleural effusions in left side.Pathology (hydrothorax): cancer cell is found.Immunohistochemistry: calretinin (is dispersed in +), CD20 (being dispersed in+), CK20 (-), CK5/6 (-), CK7 (+), Desmin (+), EMA (+), P63 (-), napsin (+), TTF- 1(+).It is diagnosed as left adenocarcinoma of lung.The patient of in September, 2018 is because cough and expectoration aggravates, blood-stained sputum silk, asthma feel suffocated it is short obvious medical, It takes after summer oyster gold disappears particle 2 months, patient's cough, expectoration, asthma is suppressed, shortness of breath symptom mitigates, and is continued to take to 4 months, Huan Zheshang State symptom improves substantially, continues to take the present invention to consolidate curative effect, follow-up symptom is without repeatedly within 2 months 2019.
The above is merely preferred embodiments of the present invention, be not intended to limit the invention, it is all in spirit of the invention and Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (10)

  1. The formula 1. a kind of summer oyster gold for treating lung cancer disappears, which is characterized in that be grouped as by the group of following parts by weight:
    6~10 parts of prepared RHIZOMA PINELLIZE without adju-vant, 3~7 parts of bulbus fritillariae cirrhosae, 9~12 parts of dried orange peel, 23~35 parts of oyster, 10~23 parts of Poria cocos, salvia chinensis 10 ~15 parts, 15~25 parts of Radix Astragali, 8~15 parts of the root of straight ladybell, 7~10 parts of Radix Angelicae Sinensis, 8~13 parts of sweet aster, 8~13 parts of sweet tussilago, cat 26~33 parts of pawl grass, 2~5 parts of licorice.
  2. The formula 2. a kind of summer oyster gold for treating lung cancer according to claim 1 disappears, which is characterized in that by following parts by weight Group is grouped as:
    8 parts of prepared RHIZOMA PINELLIZE without adju-vant, 5 parts of bulbus fritillariae cirrhosae, 11 parts of dried orange peel, 28 parts of oyster, 17 parts of Poria cocos, 13 parts of salvia chinensis, 20 parts of Radix Astragali, the root of straight ladybell 12 Part, 8 parts of Radix Angelicae Sinensis, 10 parts of sweet aster, 10 parts of sweet tussilago, 29 parts of radix ranunculi ternati, 4 parts of licorice.
  3. The preparation method of particle 3. a kind of summer oyster gold for treating lung cancer disappears, which comprises the following steps:
    S1. disappear formula according to a kind of summer oyster gold for treating lung cancer of claims 1 or 2, it is spare to weigh each component；
    S2. prepared RHIZOMA PINELLIZE without adju-vant, bulbus fritillariae cirrhosae, dried orange peel, oyster, Poria cocos, salvia chinensis, Radix Astragali, the root of straight ladybell, Radix Angelicae Sinensis, radix ranunculi ternati, licorice are added Water impregnates, and obtains wet medicinal material group one；
    S3. water is added in sweet aster, sweet tussilago to impregnate, obtains wet medicinal material group two；
    S4. it mixes, obtains with the wet medicinal material group one that step S2 is obtained after the lixivium of the obtained wet medicinal material group two of step S3 being removed To wet medicinal material is mixed, extraction is added water to cook, filtrate is obtained；
    S5. filtrate concentration, spray drying step S4 obtained, obtains dried cream powder；
    S6. dextrin is added in dried cream powder step S5 obtained, pelletizes after mixing, instills ethanol wet agent, obtains after mixing Wet granular；
    S7. wet granular step S6 obtained is dry, obtains a kind of summer oyster gold for treating lung cancer and disappears particle.
  4. The preparation method of particle 4. a kind of summer oyster gold for treating lung cancer according to claim 3 disappears, which is characterized in that step Extraction is added water to cook in S4 specifically: amount of water is 6~10 times of wet quality of medicinal material, is decocted 1~3 time, and each decocting time is 1 ~2 hours.
  5. The preparation method of particle 5. a kind of summer oyster gold for treating lung cancer according to claim 4 disappears, which is characterized in that step Extraction is added water to cook in S4 specifically: amount of water is 8 times of wet quality of medicinal material, is decocted 2 times, and each decocting time is 1.5 hours.
  6. The preparation method of particle 6. a kind of summer oyster gold for treating lung cancer according to claim 3 disappears, which is characterized in that step Stevioside is added when being concentrated in S5, and the mass ratio of the stevioside and medicinal material total amount is 2:175.
  7. The preparation method of particle 7. a kind of summer oyster gold for treating lung cancer according to claim 3 disappears, which is characterized in that step Relative density 1.06~1.20 is concentrated into S5.
  8. The preparation method of particle 8. a kind of summer oyster gold for treating lung cancer according to claim 3 disappears, which is characterized in that step S5 concentration after be spray-dried before further include alcohol precipitation: into concentrate be added 95% ethyl alcohol stir to concentration of alcohol be 55%~ 65%, 24 hours are stood, supernatant centrifugation is taken, ethyl alcohol is recovered under reduced pressure.
  9. The preparation method of particle 9. a kind of summer oyster gold for treating lung cancer according to claim 8 disappears, which is characterized in that step Stirring to concentration of alcohol is 60% in S5.
  10. The preparation method of particle 10. a kind of summer oyster gold for treating lung cancer according to claim 3 disappears, which is characterized in that step The mass ratio of dried cream powder and dextrin is 1:2 in rapid S6, and concentration of alcohol is 60% in ethanol wet agent.
CN201910369514.7A 2019-06-05 2019-06-05 Xia shu jin xiao granules for treating lung cancer and preparation method thereof Expired - Fee Related CN110013517B (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101195022A (en) * 2007-12-03 2008-06-11 门连社 Chinese medicine prescription for curing tumor
CN107875283A (en) * 2017-12-05 2018-04-06 山东大学齐鲁医院 A kind of Chinese medicine compound prescription for treating lung cancer and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101195022A (en) * 2007-12-03 2008-06-11 门连社 Chinese medicine prescription for curing tumor
CN107875283A (en) * 2017-12-05 2018-04-06 山东大学齐鲁医院 A kind of Chinese medicine compound prescription for treating lung cancer and preparation method thereof

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