CN1099881C - 'Anshenwan' for treating male infertility - Google Patents
'Anshenwan' for treating male infertility Download PDFInfo
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- CN1099881C CN1099881C CN00115984A CN00115984A CN1099881C CN 1099881 C CN1099881 C CN 1099881C CN 00115984 A CN00115984 A CN 00115984A CN 00115984 A CN00115984 A CN 00115984A CN 1099881 C CN1099881 C CN 1099881C
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Abstract
The present invention relates to Anshenwan for treating male infertility. In the preparation of the present invention, hairy antler, human placenta, epimedium herb, sea horse, prepared rehmannia root, barbary wolfberry fruit, ginseng and astragalus root are made into powder, a pill is formed by uniformly stirring by water, and then the present invention is obtained after a drying process. The present invention has the advantages of scientific and reasonable compatibility, rich raw material, easy production, convenient taking and good effect. The popularization and the application of the present invention can certainly make creative contribution for treating male infertility, and the present invention creates happiness for human beings.
Description
The present invention relates to a kind of Chinese medicine pill (claiming KidneyHarmonizing Pill again) for the treatment of male infertility.
Male infertility is a kind of common frdquently encountered disease, and is also in rising trend in recent years.Male infertility all is that the matter or the amount of sperm has problems in various degree usually.The harm patient's that this disease is not only serious physical and mental health, and usually also can therefore cause breaking of marriage and family, cause unstable factor to society.Just because of this, in today of scientific and technical order benefit fast development, the medical matters scientist treats male infertility at the various medicines of development by fair means or foul, as various strong kidney balls, the kidney invigorating ball, though the medicine of multiple treatment male infertility is arranged in the present society, as a whole, its effect is also unsatisfactory, remains to be looked forward to the appearance of new medicine.
Purpose of the present invention just provides a kind of Chinese medicine pill of new treatment male infertility, can be used to solve the problem of treatment male infertility effectively.
The object of the present invention is achieved like this, according to the Chinese medicine and pharmacy principle, male infertility causes because of deficiency of kidney-QI and genital disease, its performance can be branch two classes: a class is not normal by male's function, negative and positive are uneven causes, with suffer from a deficiency of the kidney, a little less than the spleen, excess of the liver is impotence, premature ejaculation, seminal emission, spermatorrhea, anejaculation, few essence, azoospermia, the seminal fluid not liquefaction of pathological characteristic; Another kind of is the inflammation of the urogenital system that caused by condyloma acuminatum, mycoplasma, chlamydia, chancroid, caries callosa etc., mainly comprise acute and chronic prostatitis, prostate hyperplasia, orchitis, seminal vesiculitis, urethritis, also have that reproductive development is bad, varicocele, inguinal hernia, cryptorchidism, hydrocele of testis, and vitamin A, E shortage, immunoreation etc.At above situation, the present invention is based on the kidney invigorating shape sun, doublely control the disease of holding concurrently, employing is in weight percent: Cornu Cervi Pantotrichum 3.93%, Placenta Hominis 17.67%, Herba Epimedii 24.53%, Hippocampus 5.30%, Radix Rehmanniae Preparata 22.08%, Fructus Lycii 8.83%, Radix Ginseng 8.83%, the Radix Astragali 8.83% are processed into Chinese medicine powder through the science compatibility, mix into ball thoroughly by water, the dry KidneyHarmonizing Pill that promptly constitutes the treatment male infertility.
Its compatibility of the present invention is scientific and reasonable, and abundant raw materials is easily produced, and taking convenience is effective, easily popularization and application, and be that the treatment male infertility is made creative contribution, bring benefit to the mankind.
Below in conjunction with concrete condition the present invention is elaborated.
The present invention constitutes in weight percent according to above-mentioned compatibility component: Cornu Cervi Pantotrichum 3.93%, Placenta Hominis 17.67%, Herba Epimedii 24.53%, Hippocampus 5.30%, Radix Rehmanniae Preparata 22.08%, Fructus Lycii 8.83%, Radix Ginseng 8.83%, the requirement of the Radix Astragali 8.83%, with Cornu Cervi Pantotrichum 40 grams, Placenta Hominis 180 grams, Herba Epimedii 250 grams, Hippocampus 54 grams, Radix Rehmanniae Preparata 225 grams, Fructus Lycii 90 grams, Radix Ginseng 90 grams, the Radix Astragali 90 grams, more than eight the flavor, Cornu Cervi Pantotrichum, Hippocampus is ground into fine powder separately, after all the other Placenta Hominiss etc. mix, be ground into fine powder, sieve, mixing, again with above-mentioned fine powder facing-up, sieve, mixing, use water pill, drying, packing gets final product.
Medicine in the component, the sweet temperature of Cornu Cervi Pantotrichum, kidney-replenishing, benefiting essence-blood are monarch drug; Herba Epimedii, Placenta Hominis, Hippocampus the kidney warming shape sun with the merit of principal drug assistance, are ministerial drug; Radix Rehmanniae Preparata, Fructus Lycii nourishing YIN and supplementing blood are taken into account in the hope of negative and positive, prevent dry the moon that is impairment of the kidney of medicine of YANG invigorating simultaneously; The Radix Ginseng strongly invigorating primordial QI, Radix Astragali replenishing QI to invigorate the spleen, the two share, and tonify deficiency is set upright, and strong shape muscle power is adjuvant drug, and all medicines share, and negative and positive are coordinated, the kidney qi abundance, all cards are eliminated naturally, can be used for the treatment of male infertility effectively.
KidneyHarmonizing Pill of the present invention meets the quality standard that Chinese medicine is stipulated fully through medicine inspection, and to three batches of drug inspections, its situation is through the institute for drug control, Zhengzhou City:
| Project | Standard | The result | Remarks |
| Moisture | ＜9.0％ | 7.9-8.4％ | This medicine is the pitchy watered pill, mildly bitter flavor, feeble QI raw meat |
| Mass discrepancy | Should be up to specification | Up to specification | |
| The molten medicine time | Should be in 1 hour | 41-43 minute |
Meet quality index regulation (the medicine inspection statement of seeing Appendix) fully.
The method of inspection: (1) is got this product and is put the microscopically observation, and the parenchyma taupe brown is to black, and the many shrinkages of cell include brown nuclear shape thing.It is faint yellow to plant the skin stone cell, the bending of wall ripple, and cell contains brown thing.The phloem fiber bunchy, wall thickness, there is longitudinal grin on the surface, and two ends fragment into broom shape or more truncate.
(2) get this product 10g and grind well, add 70% ethanol 30ml, supersound process 20 minutes filters, and filtrate is put and is concentrated into about 1ml in the water-bath, as need testing solution.Other gets the glycine reference substance, adds the solution that the every 1ml of 70% ethanol system contains 2mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia nineteen ninety-five version), draw need testing solution 10 μ l, reference substance solution 1 μ l, put respectively in containing on the silica gel g thin-layer plate that sodium carboxymethyl cellulose is a binding agent together, with n-butyl alcohol-glacial acetic acid-water (3: 1: 1) is developing solvent, launch, take out, dry, spray with 2% 1,2,3-indantrione monohydrate acetone soln, at 1050 ℃ of baking approximate numbers minute.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show identical pink speckle.
(3) get this product 10g, porphyrize adds chloroform 40ml, puts in the water-bath reflux 1 hour, filter, discard chloroform solution, medicinal residues volatilize solvent, add water 5ml, stir evenly, moistening after, add water saturated n-butyl alcohol 40ml, supersound process 30 minutes is drawn supernatant, adds the ammonia solution triplication, shake up, place, make layering, get upper strata liquid evaporate to dryness, residue adds methanol 1ml makes dissolving, as need testing solution.Other gets ginsenoside Rg1, Re, Rb1 reference substance and adds methanol and make mixed liquor that every 1ml contains 2mg product solution in contrast, test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia nineteen ninety-five version), draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate (500 μ m), lower floor's solution of placing below 10 ℃ with chloroform-methanol-water (65: 35: 10) is developing solvent: launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, 105 ℃ of bakings several minutes, put under the daylight and inspect.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.Meet every regulation relevant under the pill item (1995 appendix 1A of Chinese Pharmacopoeia).The quality standard of relevant KidneyHarmonizing Pill please see Appendix " the KidneyHarmonizing Pill quality standard is drafted explanation ".
The present invention is used for the treatment of male infertility and has obtained compellent good result.Following clinical observation on the therapeutic effect data is just provable.
1, the standard that defines male infertility is: the couple at child-bearing age lives together more than 2 years after marriage, does not take any contraceptives, and is former thereby cause woman side infertile by the bridegroom's or husband's side.
2, case is selected: since 1993, treated patient's 891 examples altogether, 26 years old of age minimum, maximum 46 years old, 349 examples in 26-31 year wherein, 32-36 year 364 examples, 178 examples in 37-46 year, marriageable age is at 3-18; Carried out semen efamination in these patients before treatment all, situation is: sperm quantity is 10 * 10
6-40 * 10
6237 examples of/ml, 1 * 10
6-10 * 10
6399 examples of/ml, 1 * 10
6222 examples that/ml is following, azoospermia 33 examples; Motility of sperm II ° of 429 examples, I ° of 280 examples, 0 ° of 174 example; And 426 examples of preceding alignment inflammation are arranged, 45 examples of orchitis history are arranged, can have sexual intercourse and 51 examples that can not ejaculate, have hands to draw 289 examples of history, send out grow the allelotaxis bad 138 examples are arranged.
3, diagnostic criteria is with reference to the clinical guidance principle of new Chinese medicine treatment male infertility.
4, Therapeutic Method: every day 3 times, each (medicine) being taken before meal 10-12 gram, 30 days is a course of treatment, treatment 2-6 month, part patient treatment 2 months promptly stops treatment after obtaining effect.
5, criterion of therapeutical effect: with reference to the clinical research guideline of new Chinese medicine treatment male infertility, healing is treatment 2-6 month, and the spouse becomes pregnant; Produce effects is treatment 2-6 month, spouse's unpregnancy, but sperm quantity and vigor inspection are normal; Effectively be treatment 2-6 month, sperm function is undesired, but have the group and between improve; Invalid is 6 months no changes of treatment.
6, treatment statistical result is to cure 447 examples in 891 examples, accounts for 50.2%, and produce effects 252 examples account for 28.3%, and effective 148 examples account for 16.6%, and invalid 44 examples account for 4.9%, and total effective rate is 95.1%.This shows that it is extraordinary that the present invention is used for the treatment of its effect of male infertility, particularly treatment is because the male infertility that renal function physiology aspect causes has been started the new world with tcm therapy treatment male infertility.Bottom also proves the surprising part of curative effect of the present invention by the typical clinical example:
Hebei patient Lee married with wife before 7 years because not fertility of wife, he at that time and do not know it is oneself defect, on the contrary everyday with wife's quarrel, also to divorce with him.After people's advice, Lee removes examination in hospital, finds " sperm survival rate is low ", knows that just all defect are all Lee.He not only feels oneself inferior, also feel to do one's parents disservice and wife, at heart back millstone around one's neck.After take medicine of the present invention, treat two courses of treatment continuously after, do semen efamination again, its sperm survival rate has had very big raising, after 1 year, wife has been pregnant finally.
22 years old the student at school Wang of Zhengzhou university promptly begins masturbation middle class hour, can not disconnect always, and school grade continues to descend in the recent period, hypomnesis, and frequent face tide, tinnitus, seminal emission is continuous, and listlessness is depressed.Wang's secondary sex characteristics is not grown fully after diagnosing, and causes the reproductive development bad phenomenon, the fertility of certain influence after marriage in the future.Taking medicine reexamined after half a year, and disease remarkable improvement and body and mind all recover well, and school work is also coming out at the top in the class always.
28 years old Zhang works in Zhengzhou, suffer from prostatitis for many years, cause him sterile always after marriage, under Duo Jia seeks medical advice fruitless situation, have the idea that has a try in arms, taken KidneyHarmonizing Pill of the present invention, treat after one month, patient's paruria is clearly better, after three months, originally twine Zhang's prostate misery for many years and all disappeared, recovered reproductive function.
Xiayi County, Henan Province Wu, because of the not fertility of son's wife in 5 years of marrying, the layman advises down and checks, is diagnosed as male infertility, suits the remedy to the case then and takes KidneyHarmonizing Pill, through a treatment cycle, infertility is good miraculously, and it is pregnant that wife has been, nowadays, two openning dates got tasteful, and one's cup runs over.
By above situation, find out that clearly the KidneyHarmonizing Pill of the present invention's original creation is used tcm therapy, has done creationary contribution for capturing male infertility, for Chinese materia medica has increased new wonderful work.
Claims (2)
1, a kind of Chinese medicine pill for the treatment of male infertility, it is characterized in that it being by becoming medicated powder in weight percent Cornu Cervi Pantotrichum 3.93%, Placenta Hominis 17.67%, Herba Epimedii 24.53%, Hippocampus 5.30%, Radix Rehmanniae Preparata 22.08%, Fructus Lycii 8.83%, Radix Ginseng 8.83%, the Radix Astragali 8.83% powder, after water is mixed into the ball drying thoroughly, making.
2, according to the Chinese medicine pill of claims 1 described treatment male infertility, it is characterized in that said Chinese medicine pill is to restrain into medicated powder by Cornu Cervi Pantotrichum 40 grams, Placenta Hominis 180 grams, Herba Epimedii 250 grams, Hippocampus 54 grams, Radix Rehmanniae Preparata 225 grams, Fructus Lycii 90 grams, Radix Ginseng 90 grams, the Radix Astragali 90, use water pill, drying forms.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00115984A CN1099881C (en) | 2000-08-25 | 2000-08-25 | 'Anshenwan' for treating male infertility |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00115984A CN1099881C (en) | 2000-08-25 | 2000-08-25 | 'Anshenwan' for treating male infertility |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1287841A CN1287841A (en) | 2001-03-21 |
| CN1099881C true CN1099881C (en) | 2003-01-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00115984A Expired - Fee Related CN1099881C (en) | 2000-08-25 | 2000-08-25 | 'Anshenwan' for treating male infertility |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041087B (en) * | 2012-11-29 | 2014-05-28 | 宁国市中医肿瘤医院 | Traditional Chinese medicine decoction for treating infertility |
| CN110133172A (en) * | 2019-06-12 | 2019-08-16 | 贵州联盛药业有限公司 | The thin layer for joining rhizoma atractylodis, nutmeg and red ginseng in times Guchang capsule identifies measuring method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1097998A (en) * | 1993-07-24 | 1995-02-01 | 高风兰 | Shengliyangshengye-nourishing liquid for building up strength |
| CN1132089A (en) * | 1995-03-24 | 1996-10-02 | 隆全富 | Chinese medicine for strengthening Yang and nurishing kidney |
-
2000
- 2000-08-25 CN CN00115984A patent/CN1099881C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1097998A (en) * | 1993-07-24 | 1995-02-01 | 高风兰 | Shengliyangshengye-nourishing liquid for building up strength |
| CN1132089A (en) * | 1995-03-24 | 1996-10-02 | 隆全富 | Chinese medicine for strengthening Yang and nurishing kidney |
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| Publication number | Publication date |
|---|---|
| CN1287841A (en) | 2001-03-21 |
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