CN109966445A - 一种大黄白芷活血排脓膏及其制备方法 - Google Patents

一种大黄白芷活血排脓膏及其制备方法 Download PDF

Info

Publication number
CN109966445A
CN109966445A CN201711450079.8A CN201711450079A CN109966445A CN 109966445 A CN109966445 A CN 109966445A CN 201711450079 A CN201711450079 A CN 201711450079A CN 109966445 A CN109966445 A CN 109966445A
Authority
CN
China
Prior art keywords
apocenosis
blood circulation
dahurain angelica
rheum officinale
invigorating blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711450079.8A
Other languages
English (en)
Inventor
刘海燕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201711450079.8A priority Critical patent/CN109966445A/zh
Publication of CN109966445A publication Critical patent/CN109966445A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125Camphor; Nuclear substituted derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/04Sulfur, selenium or tellurium; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • A61K36/575Magnolia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/744Gardenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884Arisaema, e.g. Jack in the pulpit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明公开了一种大黄白芷活血排脓膏及其制备方法,采用大黄、白芷、姜黄、黄栀、天南星、陈皮、苍术、厚朴、甘草、花粉为原料,经过粉碎与配料混合制备出外敷膏,可方便实现活血排脓,治疗多发性毛囊炎之目的;本发明大黄白芷活血排脓膏外敷患处,每八小时换药一次,具有调节神经系统,促进睡眠,增强体质;改善肠胃功能,促进消化,增强食欲,防治习惯性便秘;具有祛风湿,活血排脓,生肌止痛的作用,用于开窍醒神,清热散毒,明目退翳;对各种毛囊炎等病症,均有一定的治疗效果;使用方便、快捷,疗效好,不用口服,无毒副作用,治疗费用低。

Description

一种大黄白芷活血排脓膏及其制备方法
技术领域
本发明涉及中药膏的技术领域,尤指一种大黄白芷活血排脓膏及其制备方法。
背景技术
多发性毛囊炎是化脓性球菌侵犯毛囊口周围的一种炎性改变,毛囊炎初起为红色充实性丘疹,以后迅速发展成丘疹性脓疮,发于头部的就称为头皮毛囊炎。生于下颌部者称"羊须疮"、"须疮"、"燕窝疮";发于眉间者称"眉恋疮";发于臀部者称"坐板疮"等。 中医学根据其发病部位及形状有不同的命名,如大珠疮、发际疮、羊胡子疮、蝼蛄疖、蝼蛄患、蟮拱头等。本病好发于头部、项部、臀部、肛周或身体其他部位,且有复发倾向,常多处发生,性质顽固,迁延难愈。全面分型毛囊炎,随症立法、依法组方、组方给药;注意饮食生活起居,从临床治疗到生活调理。
毛囊炎多见于成年人,自觉瘙痒或有轻度疼痛,一般没有全身症状。皮疹初起时为针头大小,红色毛囊性丘疹,逐渐变成粟粒大脓疱,中心有毛发贯穿,周围有炎性红晕。脓疱大多分批出现,互不融合。脓疱破溃后,排出少量脓血,结成黄痂,痂脱即愈,不留疤痕。毛囊炎可反复发作形成慢性毛囊炎,发生于头皮的可引起永久性脱发。祖国医学理论认为,毛囊炎多由湿热内蕴,外受热邪,进而熏蒸肺系,蕴结肌肤而发。邪毒郁久化热,热盛肉腐则成脓,脓毒流窜,相互贯通,发为毛囊炎。或因素体虚弱,卫外不固,外感热毒;或因皮肤不洁,复遭风毒侵袭,风外搏结而致。如何能方便使用中药治疗烧伤,副作用小,成为广大中医工作者所关注的热点。
发明内容
本发明一种大黄白芷活血排脓膏及其制备方法,采用大黄、白芷、姜黄、黄栀、天南星、陈皮、苍术、厚朴、甘草、花粉为原料,经过粉碎与配料混合制备出外敷膏,可方便实现活血排脓,治疗多发性毛囊炎之目的。
为了实现上述目的,本发明的技术解决方案是:一种大黄白芷活血排脓膏及其制备方法的主料组分:大黄28g~30g、白芷28g~30g、姜黄28g~30g、黄栀28g~30g、天南星8g~10g、陈皮10g~12g、苍术10g~12g、厚朴10g~12g、甘草10g~12g、花粉5g~7g;
辅料组分:冰片5g~6g、樟脑9g~10g、芒硝160g~180g。
配料组分:白凡士林280g~300g。
工艺制备步骤如下:⑴粉碎:将主料组分除杂、清洗、烘干,粉碎,用100目筛过滤,得主料混合粉;将辅料组分粉碎,用60目筛过滤,得辅料混合粉;
⑵混合制备:在反应釜中加入配料组分,调整釜体温度60℃~65℃,搅拌均匀,再缓慢加入主料混合粉,均匀搅拌30min,再缓慢加入辅料混合粉,均匀搅拌20min,既得膏状成品。
本发明所述的主料组分的药性分析:其中,
大黄:具有实热便秘、热结胸痞、湿热泻痢、黄疸、淋病、水肿腹满、小便不利、目赤、咽喉肿痛、口舌生疮、胃热呕吐、吐血、咯血、衄血、便血、尿血、蓄血、经闭、产后瘀滞腹痛、症瘕积聚、跌打损伤、热毒痈疡、丹毒、烫伤等功效;
白芷:具有祛风湿,活血排脓,生肌止痛;用于头痛、牙痛、鼻渊、肠风痔漏、赤白带下、痈疽疮疡、皮肤瘙痒的功效;
姜黄:具有行气破瘀,通经止痛;主治胸腹胀痛,肩臂痹痛,心痛难忍,产后血痛,疮癣初发,月经不调,闭经,跌打损伤的功效;
黄栀:具有清热、泻火、凉血症状的功效;
天南星:具有能解毒消肿、祛风定惊、化痰散结;主治面神经麻痹、半身不遂、小儿惊风、破伤风、癫癎;外用治疗疮肿毒、毒蛇咬伤、灭蝇蛆症状的功效;
陈皮:具有理气降逆、调中开胃、燥湿化痰之功。主治脾胃气滞湿阻、胸膈满闷、脘腹胀痛、不思饮食、呕吐秽逆、二便不利、肺气阻滞、咳嗽痰多,亦治乳痈初起症状的功效;
苍术:具有燥湿健脾,祛风散寒,明目,辟秽。用于脘腹胀痛,泄泻,水肿,风湿痹痛,脚气痿躄,风寒感冒,雀目症状的功效;
厚朴:具有行气消积、燥湿除满、降逆平喘;食积气滞;腹胀便秘;湿阻中焦,脘痞吐泻;痰壅气逆;胸满喘咳症状的功效;
甘草:具有清热解毒、祛痰止咳、脘腹症状的功效;
花粉:具有调节神经系统,促进睡眠,增强体质;改善肠胃功能,促进消化,增强食欲,防治习惯性便秘;保肝护肝,防治贫血、糖尿病、前列腺肥大、心脑血管疾病;调节内分泌,改善机体功能症状的功效;
冰片:具有开窍醒神,清热散毒,明目退翳的功效;
樟脑:具有通关窍、利滞气、辟秽浊、杀虫止痒、消肿止痛的功效;
芒硝:具有泻热通便,润燥软坚,清火消炎去肿功效。
本发明经临床研究,治疗多发性毛囊炎有着西医治疗痛风无法取代的优势,治疗多发性毛囊炎对身体无损伤,对肝肾无副作用,药物可以快速的发挥的功效,见效快,对人体无损伤,多发性毛囊炎临床治愈率可高达98%。
本发明大黄白芷活血排脓膏外敷患处,每八小时换药一次,具有调节神经系统,促进睡眠,增强体质;改善肠胃功能,促进消化,增强食欲,防治习惯性便秘;具有祛风湿,活血排脓,生肌止痛的作用,用于开窍醒神,清热散毒,明目退翳;对各种毛囊炎等病症,均有一定的治疗效果;使用方便、快捷,疗效好,不用口服,无毒副作用,治疗费用低。
具体实施方式
实施例1
1)主料组分:大黄28g、白芷28g、姜黄28g、黄栀28g、天南星8g、陈皮10g、苍术10g、厚朴10g、甘草10g、花粉5g;
辅料组分:冰片5g、樟脑9g、芒硝180g。
配料组分:白凡士林280g。
2)工艺制备步骤如下:⑴粉碎:将主料组分除杂、清洗、烘干,粉碎,用100目筛过滤,得主料混合粉;将辅料组分粉碎,用60目筛过滤,得辅料混合粉;
⑵混合制备:在反应釜中加入配料组分,调整釜体温度60℃~65℃,搅拌均匀,再缓慢加入主料混合粉,均匀搅拌30min,再缓慢加入辅料混合粉,均匀搅拌20min,既得膏状成品。
实施例2
1)主料组分:大黄29g、白芷29g、姜黄29g、黄栀29g、天南星9g、陈皮11g、苍术11g、厚朴11g、甘草11g、花粉6g;
辅料组分:冰片5.5g、樟脑9.5g、芒硝170g。
配料组分:白凡士林290g。
2)工艺制备步骤如下:⑴粉碎:将主料组分除杂、清洗、烘干,粉碎,用100目筛过滤,得主料混合粉;将辅料组分粉碎,用60目筛过滤,得辅料混合粉;
⑵混合制备:在反应釜中加入配料组分,调整釜体温度60℃~65℃,搅拌均匀,再缓慢加入主料混合粉,均匀搅拌30min,再缓慢加入辅料混合粉,均匀搅拌20min,既得膏状成品。
实施例3
1)主料组分:大黄0g、白芷30g、姜黄30g、黄栀30g、天南星10g、陈皮12g、苍术12g、厚朴12g、甘草12g、花粉7g;
辅料组分:冰片5.5g、樟脑10g、芒硝160g。
配料组分:白凡士林300g。
2)工艺制备步骤如下:⑴粉碎:将主料组分除杂、清洗、烘干,粉碎,用100目筛过滤,得主料混合粉;将辅料组分粉碎,用60目筛过滤,得辅料混合粉;
⑵混合制备:在反应釜中加入配料组分,调整釜体温度60℃~65℃,搅拌均匀,再缓慢加入主料混合粉,均匀搅拌30min,再缓慢加入辅料混合粉,均匀搅拌20min,既得膏状成品。
以上所述,实施方式仅仅是对本发明的优选实施方式进行描述,并非对本发明的范围进行限定,在不脱离本发明技术的精神的前提下,本领域工程技术人员对本发明的技术方案作出的各种变形和改进,均应落入本发明的权利要求书确定的保护范围内。

Claims (1)

1.一种大黄白芷活血排脓膏及其制备方法,其特征是:主料组分:大黄28g~30g、白芷28g~30g、姜黄28g~30g、黄栀28g~30g、天南星8g~10g、陈皮10g~12g、苍术10g~12g、厚朴10g~12g、甘草10g~12g、花粉5g~7g;
辅料组分:冰片5g~6g、樟脑9g~10g、芒硝160g~180g;
配料组分:白凡士林280g~300g。
CN201711450079.8A 2017-12-27 2017-12-27 一种大黄白芷活血排脓膏及其制备方法 Pending CN109966445A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711450079.8A CN109966445A (zh) 2017-12-27 2017-12-27 一种大黄白芷活血排脓膏及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711450079.8A CN109966445A (zh) 2017-12-27 2017-12-27 一种大黄白芷活血排脓膏及其制备方法

Publications (1)

Publication Number Publication Date
CN109966445A true CN109966445A (zh) 2019-07-05

Family

ID=67071817

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201711450079.8A Pending CN109966445A (zh) 2017-12-27 2017-12-27 一种大黄白芷活血排脓膏及其制备方法

Country Status (1)

Country Link
CN (1) CN109966445A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112402573A (zh) * 2019-08-20 2021-02-26 梁德权 一种治疗毛囊炎疾病的药物配制方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112402573A (zh) * 2019-08-20 2021-02-26 梁德权 一种治疗毛囊炎疾病的药物配制方法

Similar Documents

Publication Publication Date Title
CN105477564A (zh) 一种治疗三叉神经痛的中药组合物
CN101164600A (zh) 一种治疗痤疮、青春痘的药物
WO2007019744A1 (fr) Médicament traditionnel chinois pour traiter la leucorrhée mycosique ou urine blanchâtre et turbide chez les femmes
CN109966445A (zh) 一种大黄白芷活血排脓膏及其制备方法
CN102805834B (zh) 一种治疗胃炎的药物及其制备方法
CN104435505A (zh) 一种治疗直肠炎的灌肠剂及其制备方法
CN104547748A (zh) 一种痤疮药及制备方法
CN103656596B (zh) 一种治疗肝气郁结证型咳嗽的中药
CN103191230B (zh) 一种治疗小儿复发性麦粒肿的中药
CN106138776A (zh) 治疗头痛的中药组合物及其制备方法
CN101647981B (zh) 一种治疗血虚风燥型牛皮癣的药物
CN104548013A (zh) 一种治疗面瘫的中药及其制备方法
CN102973836B (zh) 一种治疗小儿慢性荨麻疹的中药配方
CN105796992A (zh) 一种有效治疗口腔溃疡的口服液
CN106692838A (zh) 一种治疗血热型痤疮的中药
CN106880758A (zh) 一种用于外阴瘙痒和湿疹皮炎顽癣的中药制剂及制备方法
CN105125860A (zh) 一种有效治疗骨质疏松的制剂
CN104606638A (zh) 一种治疗湿热型急性湿疹的药物及其制备方法
CN105853933A (zh) 一种用于治疗乳腺癌术后复发转移的中药制剂及制备方法
CN104474161A (zh) 治疗食管癌的破瘀散及制备方法
CN104998189A (zh) 一种治疗风热乘脾型小儿口疮的中药散剂及其制备方法
CN104873627A (zh) 一种治疗荨麻疹的中药剂及制法
CN104435862A (zh) 一种治疗神经性皮炎的中药药膏及制备方法
CN104027592A (zh) 一种治疗瘀血型头痛病的中药
CN104161846A (zh) 治疗肾盂肾炎的中药制剂

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20190705

WD01 Invention patent application deemed withdrawn after publication