CN105853933A - 一种用于治疗乳腺癌术后复发转移的中药制剂及制备方法 - Google Patents
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Abstract
本发明公开了一种用于治疗乳腺癌术后复发转移的中药制剂,它是以皂角刺、蟾酥、北柴胡、醋鳖甲、土贝母、八角莲、猫爪草、夏枯草、天葵子、王不留行、漏芦、路路通、全瓜蒌、蒲公英、艾叶、芙蓉叶、露蜂房、土鳖虫、山慈菇、生薏苡仁、斑蝥、白蒺藜、郁金为原料,属于中药发明领域。根据每味中药的不同特性,以洗净切块预处理后,按比例配制,经特殊方法制作,具有清热解毒、消肿散结、平肝解郁、活血行气的作用,本发明产品组合及制作方法独特,经临床验证,该药治疗效果显著,治疗周期短,价格低廉,无不良反应和任何毒副作用,具有广阔的市场应用前景。
Description
技术领域
本发明涉及一种中药制剂,具体涉及一种用于治疗乳腺癌术后复发转移的中药制剂,本发明还涉及该中药制剂的制备方法。
背景技术
乳腺是由皮肤、纤维组织、乳腺腺体和脂肪组成的,乳腺癌是发生在乳腺腺上皮组织的恶性肿瘤。乳腺癌中99%发生在女性,男性仅占1%。乳腺并不是维持人体生命活动的重要器官,原位乳腺癌并不致命;但由于乳腺癌细胞丧失了正常细胞的特性,细胞之间连接松散,容易脱落。癌细胞一旦脱落,游离的癌细胞可以随血液或淋巴液播散全身,形成转移,危及生命。目前乳腺癌已成为威胁女性身心健康的常见肿瘤。
乳腺癌术后复发转移是患者进行乳腺癌治疗后出现的癌细胞复发转移到患者其他身体部位。出现复发转移后也完全有临床治愈的机会,目前,乳腺癌术后复发转移尚无特效疗法。三苯氧胺、氨格鲁米特等有一定疗效。但长期或短时间使用这些药物进行治疗,可引起肥胖、多毛、痤疮、血糖升高、高血压、水肿、恶心、呕吐、头晕,便秘等等一系列副作用症状,停药后原发病变反跳加重与继发的副作用,可使患者产生很大的痛苦,治疗过程反反复复,效果不明显,费用高等,给患者的造成较大的心里压力和病痛压力。
发明内容
本发明的目的在于提供一种用于治疗乳腺癌术后复发转移的中药制剂,该中药制剂对于治疗乳腺癌术后复发转移具有治疗效果显著,治愈时间短,价格低廉,无不良反应和副毒作用的特点。
发明人在多年的临床医疗实践中,根据该病症的发展规律,以及中药的配伍原则,并通过大量的临床验证,反复探索总结出用于治疗乳腺癌术后复发转移的中药制剂的新配方。本发明具有治疗效果显著,治愈时间短,价格低廉,无不良反应和副毒作用的特点。
本发明中药物的作用:
其中:
皂角刺:为豆科植物皂荚Gleditsia sinensis Lam. 的干燥棘刺。性味:辛,温。归肝、胃经。功效:消肿托毒,排脓,杀虫。用于痈疽初起或脓成不溃;外治疥癣麻风。《纲目》中记载:治痈肿,妒乳,风疠恶疮,胞衣不下,杀虫。
蟾酥:为蟾蜍科动物中华大蟾蜍 Bufo bufo gargarizans Cantor或黑眶蟾蜍B. melanostictus Schneider的干燥分泌物。蟾酥粉:取蟾酥,捣碎,加白酒浸渍,时常搅动至呈稠膏状,干燥,粉碎。每10kg蟾酥,用白酒20kg。性味:辛,温;有毒。归心经。功效:解毒,止痛,开窍醒神。用于痈疽疔疮,咽喉肿痛,中暑神昏,腹痛吐泻。
北柴胡:为伞形科植物柴胡Bupleurum chinense DC.或狭叶柴胡Bupleurum
scorzonerifolium Willd.的干燥根。性味:苦,微寒。归肝、胆经。功效:和解表里,疏肝,升阳。用于感冒发热,寒热往来,胸胁胀痛,月经不调,子官脱垂,脱肛。《纲目》中记载:治阳气下陷,平肝、胆、三焦、包络相火。
醋鳖甲:为鳖科动物鳖 Trionyx sinensis Wiegmann的背甲。性味:咸,微寒。归肝、肾经。功效:滋阴潜阳,软坚散结,退热除蒸。用于阴虚发热,劳热骨蒸,虚风内动,经闭,癓瘕,久疟疟母。《药性论》中记载:主宿食、症块、痃癖气、冷瘕、劳瘦,下气,除骨热,骨节间劳热,结实壅塞。治妇人漏下五色羸瘦者。
土贝母:为葫芦科植物土贝母Bolbostemma paniculatum(Maxim.) Franquet 的干燥块茎。性味: 苦,微寒。归肺、脾经。功效:散结,消肿,解毒。用于乳痈,瘰疬,乳腺炎,颈淋巴结结核,慢性淋巴结炎,肥厚性鼻炎。
八角莲:为小檗科八角莲属植物八角莲Dysosma pleiantha (Hance)
Woods.[Podophyllum pleiantha Hance]或八角金盘D.
versipellis (Hance) M. Cheng,以根状茎入药。性味:甘、味苦,凉。有小毒。功效:清热解毒,活血化瘀。主治:毒蛇咬伤,跌打损伤;外用治虫蛇咬伤,痈疮疖肿,淋巴结炎,腮腺炎,乳腺癌。《广西中药志》中记载:清热化痰,解蛇虫毒。治肺热痰咳,虫蛇咬伤,单双蛾喉痛,疮疖。
猫爪草:为毛茛科植物小毛茛Ranunculus ternatus Thunb. 的干燥块根。性味:甘、辛,温。归肝、肺经。功效:散结,消肿。用于瘰疬未溃、淋巴结结核。《河南中草药手册》中记载:消肿,截疟。治瘰疬,肺结核。
夏枯草:为唇形科植物夏枯草Prunella vulgaris L. 的干燥果穗。性味:辛、苦,寒。归肝、胆经。功效:清火,明目,散结,消肿。用于目赤肿痛,目珠夜痛,头痛眩晕,瘰疬,瘿瘤,乳痈肿痛;甲状腺肿大,淋巴结结核,乳腺增生,高血压。《本经》中记载:主寒热、瘰疬、鼠瘘、头疮,破症,散瘿结气,脚肿湿痹。
天葵子:为毛茛科植物天葵Semiaquilegia adoxoides (DC.)Makino 的干燥块根。性味:甘、苦,寒。归肝、胃经。功效:清热解毒,消肿散结。用于痈肿疔疮,乳痈,瘰疠,毒蛇咬伤。《云南中草药》中记载:止血散瘀,生肌止痛。
王不留行:为石竹科植物麦蓝菜Vaccaria segetalis (Neck.)Garcke 的干燥成熟种子。性味:苦,平。归肝、胃经。功效:活血通经,下乳消肿。用于乳汁不下,经闭,痛经,乳痈肿痛。
漏芦:为菊科植物祁州漏芦Rhaponticum uniflorum (L.)DC.的干燥根。性味:苦,寒。归胃经。功效:清热解毒,消痈,下乳,舒筋通脉。用于乳痈肿痛,痈疽发背,瘰疬疮毒,乳汁不通,湿痹拘挛。《本经》中记载:主皮肤热,恶疮疽痔,湿痹,下乳汁。
路路通:为金缕梅科植物枫香树Liquidambar formosana Hance的干燥成熟果序。性味:苦,平。归肝、肾经。功效:祛风活络,利水通经。用于关节痹痛,麻木拘挛,水肿胀满,乳少经闭。《纲目拾遗》中记载:辟瘴却瘟,明目,除湿,舒筋络拘挛,周身痹痛,手脚及腰痛,焚之嗅其烟气皆愈。
全瓜蒌:为葫芦科植物栝楼或双边栝楼的干燥成熟果实。功效:清热涤痰,宽胸散结,润燥滑肠。用于肺热咳嗽,痰浊黄稠,胸痹心痛,结胸痞满,乳痈,肺痈,肠痈肿痛,大便秘结。
蒲公英:为菊科植物蒲公英Taraxacum mongolicum Hand.-Mazz. 、碱地蒲公英Taraxacum sinicum Kitag.或同属数种植物的干燥全草。春至秋季花初开时采挖,除去杂质,洗净,晒干。性味:苦、甘,寒。归肝、胃经。主治:清热解毒,消肿散结,利尿通淋。用于疔疮肿毒,乳痈,瘰疠,目赤,咽痛,肺痈,肠痈,湿热黄疸,热淋涩痛。
艾叶:为菊科植物艾Artemisia argyi Levl. et Vant. 的干燥叶。性味:辛、苦,温;有小毒。归肝、脾、肾经。功效:散寒止痛,温经止血。用于少腹冷痛,经寒不调,宫冷不孕,吐血,衄血,崩漏经多,妊娠下血;外治皮肤瘙痒。醋艾炭温经止血。用于虚寒性出血。《唐本草》中记载:主下血,衄血,脓血痢,水煮及丸散任用。
芙蓉叶:为锦葵科植物木芙蓉Hibiscus mutabilis L.的叶。性味:性凉,味微辛。功效:清肺凉血,消肿排脓。用于肺热咳嗽、肥厚性鼻炎、淋巴结炎、阑尾炎、痈疖脓肿、急性中耳炎、烧伤、烫伤。
露蜂房:为胡蜂科昆虫大黄蜂或同属近缘昆虫的巢。性味:甘,平,有毒。归肝、肺经。功效:祛风,攻毒,杀虫。治惊痫,风痹,瘾疹瘙痒,乳痈,疔毒,瘰疬,痔漏,风火牙痛,头癣,蜂螫肿疼。《本经》中记载:主惊痫瘈疭,寒热邪气,癫疾,肠痔。
土鳖虫:为鳖蠊科昆虫地鳖Eupolyphaga sinensis Walker 或冀地鳖Steleophaga plancyi(Boleny)的雌虫干燥体。性味:咸,寒;有小毒。归肝经。功效:破瘀血,续筋骨。用于筋骨折伤,瘀血经闭,症瘕痞块。
山慈菇:为兰科植物杜鹃兰Cremastra appendiculata (D.Don)Makino、独蒜兰Pleione bulbocodioides(Franch.)Rolfe 或云南独蒜兰Pleione
yunnanensis Rolfe的干燥假鳞茎。性味: 甘、微辛,凉。归肝、脾经。功效:清热解毒,化痰散结。用于痈肿疔毒,瘰疬痰核,淋巴结结核,蛇虫咬伤。
生薏苡仁:为禾本科植物薏苡Coix lacryma-jobi L. var. ma-yuen (Roman.)Stapf的干燥成熟种仁。性味:甘、淡,凉。归脾、胃、肺经。功效:健脾渗湿,除痹止泻,清热排浓。用于水肿,脚气,小便不利,湿痹拘挛,脾虚泄泻,肺痈,肠痈;扁平疣。《纲目》中记载:健脾益胃,补肺清热,去风胜湿。炊饭食,治冷气;煎饮,利小便热淋。
斑蝥:为芫菁科昆虫南方大斑蝥Mylabris phalerata Pallas 或黄黑小斑蝥Mylabris cichorii Linnaeus 的干燥体。性味:辛,热;有大毒。归肝、胃、肾经。功效:破血消癓,功毒蚀疮,引赤发泡。用于癓瘕肿块,积年顽癣,瘰疬,赘疣,痈疽不溃,恶疮死肌。《本经》中记载:主寒热,鼠瘘,恶疮疽,蚀死肌,破石癃。
白蒺藜:为蒺藜科植物蒺藜Tribulus terrestris L. 的干燥成熟果实。性味:辛、苦,微温;有小毒。归肝经。功能主治:平肝解郁,活血祛风,明目,止痒。用于头痛眩晕,胸胁胀痛,乳闭乳痈,目赤翳障,风疹瘙痒。
郁金:为姜科植物温郁金Curcuma wenyujin Y. H. Chen et C. Ling、姜黄Curcuma longa L.、广西莪术Curcuma
kwangsiensis S. G. Lee et C. F. Liang或蓬莪术Curcuma
phaeocaulis Val.的干燥块根。性味:辛、苦,寒。归肝、心、肺经。功效:行气化瘀,清心解郁,利胆退黄。用于经闭痛经,胸腹胀痛、刺痛,热病神昏,癫痫发狂,黄疸尿赤。《本草备要》中记载:行气,解郁;泄血,破瘀。凉心热,散肝郁。
本发明的方解是:皂角刺消肿托毒、排脓杀虫,蟾酥解毒止痛、开窍醒神,土贝母消肿解毒,八角莲清热解毒、活血化瘀,天葵子清热解毒、消肿散结,漏芦清热解毒、消痈下乳,蒲公英清热解毒、消肿散结,山慈菇清热解毒、化痰散结,醋鳖甲滋阴潜阳、软坚散结,猫爪草散结消肿,夏枯草清火明目、散结消肿,全瓜蒌清热涤痰、宽胸散结,以上十二味药作为方中君药,均归肝经,具有清热解毒、消肿散结的作用。中医学认为,本病是病的形成多邪毒外侵,内伏血分,致使细胞受损发生病变而生。所以清热解毒、消肿散结是治疗乳腺癌术后复发转移的基础,以上十二味药均为君药,首先从根本上清热解毒、消肿散结,使病症得到根本的控制。王不留行活血通经、下乳消肿,路路通祛风活络、利水通经,艾叶散寒止痛、温经止血,斑蝥破血消癓、功毒蚀疮,白蒺藜平肝解郁、活血祛风,郁金行气化瘀、清心解郁,以上六味药为方中臣药,一方面辅助君药清热解毒、消肿散结的功效;另一方面作为臣药具有平肝解郁、活血行气的功效。北柴胡和解表里、疏肝升阳,芙蓉叶清肺凉血、消肿排脓,露蜂房祛风攻毒,土鳖虫破瘀血、续筋骨,生薏苡仁健脾渗湿、清热排浓,以上五味药作为佐药,从病理上治疗引起乳腺癌术后复发转移的诱因,作为佐药既能促进君臣二药的清热解毒、消肿散结的功效,又能反佐君臣二药促进机体平肝解郁、活血行气的作用。此方诸药合用,君臣协力,臣佐共辅,具有清热解毒、消肿散结、平肝解郁、活血行气的功效,能够有效治疗乳腺癌术后复发转移。
本发明另一个重要特点是该中药制剂含有丰富的营养成分,富含氨基酸有17种以上,其中人体必需氨基酸有苏氨酸、缬氨酸、蛋氨酸、异亮氨酸、亮氨酸、赖氨酸和苯丙氨酸,含有人体必需的微量元素有铁、铬、铜、硼、锰、锶、和锌,另含钙、钾、镁、磷几种人体宏量元素。以上营养成分都是人体必需物质,能有效增强人体免疫力。
本发明药物原料用量是经发明人进行大量摸索总结得出的,各原料用量为在下述重量份范围都具有较好的疗效:皂角刺18-22份、蟾酥1-5份、北柴胡13-17份、醋鳖甲22-26份、土贝母18-22份、八角莲13-17份、猫爪草18-22份、夏枯草18-22份、天葵子13-17份、王不留行13-17份、漏芦13-17份、路路通13-17份、全瓜蒌22-26份、蒲公英18-22份、艾叶10-14份、芙蓉叶10-14份、露蜂房13-17份、土鳖虫7-11份、山慈菇18-22份、生薏苡仁22-26份、斑蝥1-5份、白蒺藜18-22份、郁金13-17份。
其中优选为:皂角刺20份、蟾酥3份、北柴胡15份、醋鳖甲24份、土贝母20份、八角莲15份、猫爪草20份、夏枯草20份、天葵子15份、王不留行15份、漏芦15份、路路通15份、全瓜蒌24份、蒲公英20份、艾叶12份、芙蓉叶12份、露蜂房15份、土鳖虫9份、山慈菇20份、生薏苡仁24份、斑蝥3份、白蒺藜20份、郁金15份。
一种用于治疗乳腺癌术后复发转移的中药制剂的制备方法如下:
步骤一:按本发明重量份配比,取醋鳖甲,粉碎,过200目筛,备用;
步骤二:按本发明重量份配比,取八角莲、艾叶、露蜂房、土鳖虫、斑蝥、白蒺藜药材置于砂锅中,加入3倍体积的水,武火熬煮20-30分钟,转文火熬煮30-40分钟,过滤滤液,反复熬煮三次,合并三次滤液,备用;
步骤三:按本发明重量份配比,取蟾酥,捣碎,按照每10kg蟾酥,用白酒20kg,加白酒浸渍,时常搅动至呈稠膏状,干燥,粉碎,磨粉,过200目筛,备用;
步骤四:按本发明重量配比,取皂角刺、北柴胡、土贝母、猫爪草、天葵子、漏芦、全瓜蒌、蒲公英、山慈菇、郁金药材置于砂锅中,加入8倍体积的水,武火熬煮20-30分钟后,加入夏枯草、芙蓉叶、及分别用纱布包扎好的生薏苡仁、王不留行、路路通、,武火熬煮10-20分钟,转文火熬煮30~40分钟得滤液,反复熬煮三次合并所得滤液,备用;
步骤五:合并步骤二、步骤四所得滤液并与步骤一、三所得粉末,混合,搅匀,既得本发明所述的治疗乳腺癌术后复发转移的汤剂。
本发明使用方法:取汤剂,饭后一小时内服用,每天三次。
本发明药物具有清热解毒、消肿散结、平肝解郁、活血行气的作用,且止痛效果好,价格低廉,无毒副作用,使用方便,该中药制剂采用的方式治疗可以减少西药对患者身体的伤害,减轻患者的病痛,据对临床240例患者观察统计,使用本发明药物一个疗程总有效率82.5%,两个疗程总有效率95%。
具体实施方式
实施例一:皂角刺20份、蟾酥3份、北柴胡15份、醋鳖甲24份、土贝母20份、八角莲15份、猫爪草20份、夏枯草20份、天葵子15份、王不留行15份、漏芦15份、路路通15份、全瓜蒌24份、蒲公英20份、艾叶12份、芙蓉叶12份、露蜂房15份、土鳖虫9份、山慈菇20份、生薏苡仁24份、斑蝥3份、白蒺藜20份、郁金15份。
实施例二:皂角刺21份、蟾酥4份、北柴胡14份、醋鳖甲22份、土贝母20份、八角莲15份、猫爪草22份、夏枯草21份、天葵子14份、王不留行14份、漏芦16份、路路通16份、全瓜蒌23份、蒲公英21份、艾叶12份、芙蓉叶13份、露蜂房16份、土鳖虫8份、山慈菇21份、生薏苡仁23份、斑蝥5份、白蒺藜21份、郁金15份。
实施例三:皂角刺22份、蟾酥2份、北柴胡16份、醋鳖甲23份、土贝母20份、八角莲14份、猫爪草21份、夏枯草21份、天葵子14份、王不留行14份、漏芦14份、路路通15份、全瓜蒌24份、蒲公英20份、艾叶12份、芙蓉叶13份、露蜂房13份、土鳖虫7份、山慈菇21份、生薏苡仁26份、斑蝥2份、白蒺藜22份、郁金16份。
下面是患者使用本发明药物的临床统计资料:
一、一般资料
收治门诊患者240例,将患者随机分为观察组和对照组各120例,其中男性10例,女性230例,男女比例1:23,最大年龄66岁,最小年龄25岁,病程几个月到几年不等。两组患者年龄、性别、病程等各项基本资料基本相同,差异无统计学意义(P>0.05)。
二、诊断标准
1、患有乳腺癌,术后出现复发转移患者。
2、骨转移:骨转移经常是多发的乳腺癌转移症状。
3、胸水、腹水:恶性体腔积液在乳腺癌患者中也常见。
4、脑转移:乳腺癌转移症状常伴有剧烈头痛,其次还会出现恶心、呕吐、行为改变以及精神活动异常等。
5、肺转移:早期多数无表现,仅在X线片中发现单发或多发的结节阴影,双肺多发较多。转移晚期才出现胸痛、干咳、咯血等乳腺癌转移症状,有时会出现胸水。
6、肝转移:肝转移是晚期病人比较多见的乳腺癌转移症状。当病人出现肝区疼痛、肝肿大、肝功能障碍、黄疸、腹水等症状时,往往已伴有全身转移。
三、治疗方法:
1、观察组按照本发明药物实施例一,称取原料药按发明实施方法治疗,取汤剂,饭后一小时内服用,每天三次。7天为一个疗程。
2、对照组采用常规西药三苯氧胺治疗,7天为一疗程。
四、疗效评定标准:
1、治愈:临床症状全部消退,基本没有留下任何后遗症。2、好转:发热、疼痛等症状消失,病情基本得到控制,偶尔出现反复。3、无效:经治疗1周以上,症状均不见好转者。
五、治疗结果统计:
对照组结果统计
使用该中药制剂两个疗程两组患者的疗效对比情况
其中:总有效率=治愈率+好转率
通过对比两组患者的治疗总有效率可以发现观察组明显高于对照组,由此说明,本发明中药在治疗乳腺癌术后复发转移上具有良好的临床效果,能有效提高治疗的治愈率,效果显著,价格低廉,无不良反应和任何毒副作用,具有广阔的市场应用前景。
典型病例及疗效:
病例一、患者王某,女,46岁,青岛市人,2014年5月20日来我处就诊。主诉:患者于2年前无意中发现右乳内上象限肿块,大小约2.1cm*2.0cm,质地硬,边界不清,活动度差,诊断为乳腺癌,后于山东省肿瘤医院做手术切除,但术后3个月发现手术部位出现肿物,右锁骨下触及皮下包块,质硬,有压痛,去医院检查并做活检诊断为乳腺癌术后复发转移。经治疗疼痛缓解,但未治愈,遂来我处治疗,采用本发明实施例一中所制制剂,以及所选的制备方法,症状减退,用药7天后,疼痛消失,患处恢复良好,继续用药6天,彻底治愈,电话随访半年未复发。
病例二、患者李某,女,32岁,山东临沂人。2015年9月14日来我处就诊,经诊断症状如下:患者于1年前无意中发现左乳内上象限肿块,大小约1.8cm*1.0cm,质地硬,边界不清,活动度差,诊断为乳腺癌,后于山东省肿瘤医院做手术切除,但术后2个月发现手术部位出现肿物,左锁骨下触及皮下包块,质硬,有压痛,去医院检查并做活检诊断为乳腺癌术后复发转。采用本发明实施例一中所制制剂,以及所选的制备方法,症状减退,疼痛感稍有减轻,用药7天后,疼痛消失,患处恢复良好,继续用药5天,彻底治愈,电话随访半年未复发。
Claims (4)
1.一种用于治疗乳腺癌术后复发转移的中药制剂,其特征在于,该中药制剂是由以下重量份的药物制成:皂角刺18-22份、蟾酥1-5份、北柴胡13-17份、醋鳖甲22-26份、土贝母18-22份、八角莲13-17份、猫爪草18-22份、夏枯草18-22份、天葵子13-17份、王不留行13-17份、漏芦13-17份、路路通13-17份、全瓜蒌22-26份、蒲公英18-22份、艾叶10-14份、芙蓉叶10-14份、露蜂房13-17份、土鳖虫7-11份、山慈菇18-22份、生薏苡仁22-26份、斑蝥1-5份、白蒺藜18-22份、郁金13-17份。
2.根据权利要求1所述的用于治疗乳腺癌术后复发转移的中药制剂,其特征在于,由以下重量份的药物制成:皂角刺20份、蟾酥3份、北柴胡15份、醋鳖甲24份、土贝母20份、八角莲15份、猫爪草20份、夏枯草20份、天葵子15份、王不留行15份、漏芦15份、路路通15份、全瓜蒌24份、蒲公英20份、艾叶12份、芙蓉叶12份、露蜂房15份、土鳖虫9份、山慈菇20份、生薏苡仁24份、斑蝥3份、白蒺藜20份、郁金15份。
3.根据权利要求1或2所述的用于治疗乳腺癌术后复发转移的中药制剂,其特征在于:所述中药制剂为汤剂。
4.一种用于治疗乳腺癌术后复发转移的中药制剂的制备方法,其特征在于,制备方法如下:步骤一:按本发明重量份配比,取醋鳖甲,粉碎,过200目筛,备用;步骤二:按本发明重量份配比,取八角莲、艾叶、露蜂房、土鳖虫、斑蝥、白蒺藜药材置于砂锅中,加入3倍体积的水,武火熬煮20-30分钟,转文火熬煮30-40分钟,过滤滤液,反复熬煮三次,合并三次滤液,备用;步骤三:按本发明重量份配比,取蟾酥,捣碎,按照每10kg蟾酥,用白酒20kg,加白酒浸渍,时常搅动至呈稠膏状,干燥,粉碎,磨粉,过200目筛,备用;步骤四:按本发明重量配比,取皂角刺、北柴胡、土贝母、猫爪草、天葵子、漏芦、全瓜蒌、蒲公英、山慈菇、郁金药材置于砂锅中,加入8倍体积的水,武火熬煮20-30分钟后,加入夏枯草、芙蓉叶、及分别用纱布包扎好的生薏苡仁、王不留行、路路通、,武火熬煮10-20分钟,转文火熬煮30~40分钟得滤液,反复熬煮三次合并所得滤液,备用;步骤五:合并步骤二、步骤四所得滤液并与步骤一、三所得粉末,混合,搅匀,既得本发明所述的治疗乳腺癌术后复发转移的汤剂。
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