CN109966222A - A kind of replenishing water and preserving moisture freckle removing and whitening brightening cream and preparation method thereof - Google Patents
A kind of replenishing water and preserving moisture freckle removing and whitening brightening cream and preparation method thereof Download PDFInfo
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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Abstract
The present invention relates to a kind of replenishing water and preserving moisture freckle removing and whitening brightening creams and preparation method thereof, the invention product uses water, 1, 3-propanediol, glycerin polyether -26, Sodium Hyaluronate, tridecanol trimellitate, neopentyl glycol dicaprylate/dicaprate, Queensland nut seed oil, Butyrospermum parkii fruit rouge, 1, 2- pentanediol, dimethyl silicone polymer, cetostearyl alcohol, stearine, PEG-40 stearate, ceteareth -20, niacinamide, triethanolamine, Turmeric P.E, glycyrrhiza glabra extract etc. is raw material and carries out appropriate weight proportion, final preparation gained replenishing water and preserving moisture freckle removing and whitening brightening cream can rapidly permeate into skin bottom, multi-efficiency is more efficient by bright color, it is low and deep to be effectively improved skin, it is obscure, freckle removing and whitening, moisture is lockked while promoting skin moisture, it is anti- It only has dry skin, smooth fine lines, promotes skin gloss.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of replenishing water and preserving moisture freckle removing and whitening brightening cream and its preparation side
Method.
Background technique
Our skin is the protective layer of body, not only resists extraneous bacterium intrusion body, skin of face is also measurement one
Personal health looks standard of beauty, exposure year in year out in air, ultraviolet irradiation, afloat dirt, dirt in air
Angstrom, the natural harmful substance of bacterium stimulate skin surface.In addition grease, sweat, the dead cell etc. of itself secretion, these factor meetings
The performance of skin normal function is influenced, or even causes dermatological infections, the skin diseases such as acne occur, skin is caused to shift to an earlier date aging.
Skin nursing has become essential link in our daily lifes.
Face cream, lotion are the most important step of basic skin care, the effective components energy such as whitening and anti-aging in face cream, lotion
It is enough well by percutaneous absorption, so for consumers, possess one bottle of good face cream and lotion be quite it is necessary to.Face
Frost is capable of providing dual anti-aging effect, can stimulate cell neogenesis energy, while promoting collagen synthesis, improves skin surface
Texture and the colour of skin uniformity, keep skin more careful.
Summary of the invention
In order to solve the above problems existing in the present technology, the present invention provides one kind can rapidly permeate into skin bottom,
Efficient bright color, freckle removing and whitening are effectively improved low and deep skin, obscure and effective replenishing water and preserving moisture brightening cream and its preparation side
Method.The replenishing water and preserving moisture freckle removing and whitening brightening cream, which is used for a long time, can effectively moisten nutrition skin, play good skin effect.
The technical scheme adopted by the invention is as follows:
A kind of replenishing water and preserving moisture freckle removing and whitening brightening cream, raw material components include:
Water 70-80 parts by weight, niacinamide 5-7 parts by weight, triethanolamine 0.5-1.5 parts by weight, EDETATE SODIUM 0.2-0.8 weight
Measure part, Queensland nut seed oil 2-4 parts by weight, Butyrospermum parkii fruit rouge 2-4 parts by weight, the (double-tert-butyl hydroxy hydrogenation of pentaerythrite four
Cinnamic acid) ester 1-3 parts by weight, -26 0.5-1.5 parts by weight of glycerin polyether, tridecanol trimellitate 1-2 parts by weight, new penta
Glycol dicaprylate/dicaprate 0.5-1.5 parts by weight, 1,3- propylene glycol 1-2 parts by weight, 1,2- pentanediol 0.3-0.8 weight
Part, Sodium Hyaluronate 2-4 parts by weight, Sensiva SC50 0.5-1.5 parts by weight, bisabolol 0.2-1.0 parts by weight, tetrahydro are recklessly
Green pepper alkali 0.01-0.1 parts by weight, PEG-40 stearate 1-3 parts by weight, -20 1-3 parts by weight of ceteareth, glycerol are hard
Resin acid ester 1-3 parts by weight, cetostearyl alcohol 1-3 parts by weight, dimethyl silicone polymer 0.5-1 parts by weight, esters of acrylic acid/C10-
30 alkylol acrylamide acid esters cross-linked polymer 0.5-1 parts by weight, Turmeric P.E 5-7 parts by weight, glycyrrhiza glabra extract 3-8 weight
Part.
The raw material components of the further preferred replenishing water and preserving moisture freckle removing and whitening brightening cream include:
75 parts by weight of water, 6 parts by weight of niacinamide, 1 parts by weight of triethanolamine, 0.6 parts by weight of EDETATE SODIUM, Queensland nut seed
It is oily 3 parts by weight, 3 parts by weight of Butyrospermum parkii fruit rouge, 2 parts by weight of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), sweet
Oily -26 1 parts by weight of polyethers, 1.5 parts by weight of tridecanol trimellitate, neopentyl glycol dicaprylate/1 weight of dicaprate
Part, 1.5 parts by weight of 1,3- propylene glycol, 0.6 parts by weight of 1,2- pentanediol, 3 parts by weight of Sodium Hyaluronate, 1 weight of Sensiva SC50
Measure part, 0.6 parts by weight of bisabolol, 0.06 parts by weight of tetrahydro piperine, 2 parts by weight of PEG-40 stearate, cetostearyl alcohol
2 parts by weight of polyethers -20,2 parts by weight of stearine, 2 parts by weight of cetostearyl alcohol, 0.8 weight of dimethyl silicone polymer
Part, esters of acrylic acid/0.8 parts by weight of C10-30 alkylol acrylamide acid esters cross-linked polymer, 6 parts by weight of Turmeric P.E, light fruit are sweet
Careless 6 parts by weight of extract.
Further, the Turmeric P.E is prepared with the following method: turmeric being cleaned, slice, at 60-70 DEG C
Drying to constant weight, and 20%-40% ethyl alcohol is added and impregnates 2-6h, turmeric and ethyl alcohol mass ratio are (5-8): 1, take out the ginger after impregnating
Yellow 40-50 DEG C of drying, is crushed to 200-300 mesh, and the water that 5-10 times of quality is added carries out ultrasonic extraction 1-3h, and Extracting temperature is
30-40 DEG C, filtrate is obtained after filtering, repeats to extract 1-3 times, merging filtrate is up to Turmeric P.E.
Further, the glycyrrhiza glabra extract is prepared with the following method: taking the root and root shape of glycyrrhiza glabra
Stem is cleaned, is sliced, and drying to constant weight at 70-90 DEG C, and 10%-30% ethyl alcohol is added and impregnates 2-6h, turmeric is with ethyl alcohol mass ratio
(4-7): 1,50-70 DEG C of turmeric drying after impregnating is taken out, is crushed to 200-300 mesh, the water that 5-10 times of quality is added is surpassed
Sound extracts 1-3h, and Extracting temperature is 30-40 DEG C, and filtrate is obtained after filtering, repeats to extract 1-3 times, merging filtrate is up to glycyrrhiza glabra
Extract.
A method of the replenishing water and preserving moisture freckle removing and whitening brightening cream is prepared, is included the following steps:
(1) by the proportion, by Queensland nut seed oil, Butyrospermum parkii fruit rouge, pentaerythrite four, (double-tert-butyl hydroxy is hydrogenated
Cinnamic acid) ester, glycerin polyether -26, tridecanol trimellitate, neopentyl glycol dicaprylate/dicaprate, 1,3- the third two
It stirs evenly, heats after alcohol, 1,2- pentanediol, Sodium Hyaluronate, Sensiva SC50, bisabolol and the mixing of tetrahydro piperine
After cool down, obtain feedstock oil phase；
(2) water, niacinamide, triethanolamine, EDETATE SODIUM be mixed and stirred for uniformly by the proportion, it is cold after heating
But, raw material water phase is obtained；
(3) it is heated after mixing the raw material water phase and feedstock oil, adds PEG-40 stearate, cetearyl alcohol
Alcohol polyethers -20, stearine and cetostearyl alcohol carry out homogeneous, and dimethyl silicone polymer and acrylate are added after cooling
Class/C10-30 alkylol acrylamide acid esters cross-linked polymer carries out homogeneous, adds Turmeric P.E after continuing cooling and glycyrrhiza glabra mentions
Object is taken, homogeneous is continued, is sterilized after adjusting pH, bottling refrigeration is to get the replenishing water and preserving moisture freckle removing and whitening brightening cream.
Further, in step (1), the mixing speed is 50-100r/min, and the mixing time is 5-10min.
Further, in step (1), the heating temperature is 80-90 DEG C, and the heating time is 10-15min.
Further, in step (2), mixing speed 50-70r/min, mixing time 5-10min.
Further, in step (2), the heating temperature is 90-100 DEG C, and the heating time is 10-15min.
Further, in step (3), the raw material water phase and feedstock oil are heated to 50-90 DEG C after mixing, and add PEG-
40 stearates, ceteareth -20, stearine and cetostearyl alcohol homogeneous 70-110s.
Further, in step (3), dimethyl silicone polymer and esters of acrylic acid/C10- are added after cooling to 40-50 DEG C
30 alkylol acrylamide acid esters cross-linked polymer homogeneous 50-80s, continue thereafter with and cool to 20-30 DEG C of addition Turmeric P.E and light fruit
Licorice, homogeneous 20-40s.
Further, in step (3), the pH is adjusted to 6.5-7.5；It is carried out using 60Co-γ rays irradiation 30-60min
Disinfection；It refrigerates in 0-4 DEG C of temperature.
It underdraws below to effect caused by primary raw material in the present invention.
Niacinamide, be vitamin B3 the generally acknowledged skin anti-aging of a kind of derivative and cosmetic dermatology field at
Part, it is increasingly concerned by people in recent years, most important effect is to mitigate and prevent skin to exist in terms of skin anti-aging
The colour of skin generated in early stage aging course is dull, turns to be yellow, famished look.Certainly, niacinamide, can also to the contribution this and more of skin
To repair impaired Stratum corneum lipids barrier, skin resistance is improved.There are also some the effect of may being ignored by people, are exactly cigarette
Deep layer water lock effect of amide, so, the skin care item containing niacinamide are to having extremely strong water lock, moisture-keeping efficacy.
Queensland nut seed oil, forms nutrient essential to grease protective layer containing skin, it is most important that and oiliness is mild,
Do not stimulate skin；Moisturiser can be made, skin can be made soft and vibrant, cell membrane is protected and moistens, moisturizing；It can also be
Body facial treatment milk adds macadimia nut oil, increases lubricity and nourishing degree；Ductility is good, there is greasy feeling, while permeability
Well, high to various essential oil solubility, it is excellent basis oil.
Butyrospermum parkii fruit rouge is moisturizing agent abundant, is easy to absorb, and is rich in unsaturated fatty acid, can reinforce the guarantor of skin
Wet ability, the skin impaired to stemness and cutin can be moistened, from Ka Lite tree (karite) extraction.Relative to other
Vegetable oil especially grows the triterpene alcohol and vitamin E, vitamin of necessary nutrient containing highest rate fat accompaniment
A, allantoin etc., it is full of nutrition.Skin moisture can be prevented to be lost, healing of wound is helped, increase skin defence capability and submissive
Degree.It is rare skin care natural component.
Turmeric P.E, modern research suggests that turmeric contains volatile oil, curcumin and annatto and norbixin
With microelement etc.；There is anti-inflammatory effect, turmeric has inhibiting effect to various bacteria, and volatile oil then has the inhibition of strength to make fungi
With；Turmeric flooding agent has different degrees of inhibiting effect to a variety of dermatophytes.
Glycyrrhiza glabra extract can go deep into inside skin and keep high activity, effectively inhibit melanin production more in the process
The activity of kind enzyme (as inhibited tyrosinase) is a kind of fast, efficient, safe, green sun-proof, whitening cosmetics addition
Agent.Glycyrrhiza glabra extract also has effects that prevent pachylosis and anti-inflammatory, antibacterial simultaneously.
Sodium Hyaluronate has and plays water conservation in vivo, maintain extracellular space, adjust osmotic pressure, lubrication, promote cell
The characteristic of reparation；Moisture-keeping function of the moisture retention Sodium Hyaluronate in skin histology is one of its most important physiological function, is filled
The moisture of foot keeps skin smooth, fine and smooth；The hygroscopic capacity highest under low relative humidity (33%) is inhaled under high relative humidity (75%)
Moisture is minimum, is just being suitble to skin under Various Seasonal, varying environment humidity to the moisturizing demand of cosmetics, and without greasy feeling and resistance
Fill in the feeling of pore；With stronger viscoelasticity and lubricity, it is applied to skin surface, one layer of moisturizing ventilated membrane can be formed, is kept
Skin moisturizing is glossy；Micromolecule hyaluronic acid sodium can penetrate into skin corium, promote blood microcirculation, be conducive to skin to nutrients
The crease-resistant health-care effect of beauty is played in the absorption of matter；The lesser Sodium Hyaluronate of quality can penetrate into skin epidermis, promote skin
The supply of nutrition and the excretion of waste play beauty and face-nursing function to prevent skin aging；By promoting epidermal cell
Proliferation and differentiation and the effect of scavenging activated oxygen, can promote the regeneration of injury skin.
Dimethyl silicone polymer has good skin-protecting function, belongs to the Synthetic Oil in cosmetic material.This product without
Poison, nonirritant to skin and mucous membrane but irritant to eyes, generally accepted is safe；With greasy property, uvioresistant
The effect of line, good permeability have apparent dust reduction capability, are also used to replace traditional glyceride stock in cosmetics, this is
There is the characteristic of preferable flexibility according to dimethyl silicone polymer, usually can be all used in moisture retention product in skin care item, it is some
High-grade skin care item also can all be applied；Very good to the permeability of skin, skin care item smear smooth salubrious sense on the skin
By, be usually all because add the raw material, raw material itself for increase skin flexibility also have good effect；It is glutinous
Spend low, volatility is good, easy to clean.
Allergic skin is protected as active constituent and nursed to bisabolol.
The invention has the benefit that
Replenishing water and preserving moisture freckle removing and whitening brightening cream of the present invention, by using water, 1,3-PD, glycerin polyether -26,
Sodium Hyaluronate, tridecanol trimellitate, neopentyl glycol dicaprylate/dicaprate, Queensland nut seed oil, Butyrospermum parkii
Fruit rouge, 1,2- pentanediol, dimethyl silicone polymer, cetostearyl alcohol, stearine, PEG-40 stearate, spermaceti are hard
Lipidol polyethers -20, niacinamide, triethanolamine, Turmeric P.E, glycyrrhiza glabra extract etc. are raw material and carry out appropriate weight and match
Than final preparation gained replenishing water and preserving moisture freckle removing and whitening brightening cream can rapidly permeate into skin bottom, and multi-efficiency is by bright color
More efficient, it is low and deep, obscure to be effectively improved skin, freckle removing and whitening, locks moisture while promoting skin moisture, prevents skin dry
Dry, smooth fine lines promote skin gloss.Each raw material compounding of the invention is reasonable, synergistic, has utmostly played each effective original
The effect of expecting moisturizing and skin lightening.The effect of extracting after wherein processing to turmeric and glycyrrhiza glabra, making its effective component obtains
Very big promotion.Preparation process of the present invention is simple, with short production cycle, is conducive to large-scale promotion.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
Embodiment 1
The present embodiment provides a kind of replenishing water and preserving moisture freckle removing and whitening brightening cream, raw material components include:
80 parts by weight of water, 5 parts by weight of niacinamide, 0.5 parts by weight of triethanolamine, 0.2 parts by weight of EDETATE SODIUM, Queensland nut
Seed oil 2 parts by weight, 2 parts by weight of Butyrospermum parkii fruit rouge, 1 parts by weight of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate),
0.5 parts by weight of glycerin polyether -26,1 parts by weight of tridecanol trimellitate, neopentyl glycol dicaprylate/dicaprate 0.5
Parts by weight, 1 parts by weight of 1,3- propylene glycol, 0.3 parts by weight of 1,2- pentanediol, 2 parts by weight of Sodium Hyaluronate, Sensiva SC50
0.5 parts by weight, 0.2 parts by weight of bisabolol, 0.01 parts by weight of tetrahydro piperine, 1 parts by weight of PEG-40 stearate, spermaceti are hard
- 20 1 parts by weight of lipidol polyethers, 1 parts by weight of stearine, 1 parts by weight of cetostearyl alcohol, 0.5 weight of dimethyl silicone polymer
Measure part, esters of acrylic acid/0.5 parts by weight of C10-30 alkylol acrylamide acid esters cross-linked polymer, 5 parts by weight of Turmeric P.E, light fruit
3 parts by weight of licorice.
Further, the present embodiment provides the preparation method of the replenishing water and preserving moisture freckle removing and whitening brightening cream, include the following steps:
(1) preparation of Turmeric P.E and glycyrrhiza glabra extract: turmeric being cleaned, slice, and drying to constant weight at 60 DEG C,
20% ethyl alcohol is added and impregnates 2h, turmeric and ethyl alcohol mass ratio are 5:1, take out 40 DEG C of turmeric drying after impregnating, are crushed to 200
Mesh, the water that 5 times of quality are added carry out ultrasonic extraction 1h, and Extracting temperature is 30 DEG C, and filtrate is obtained after filtering to get Turmeric P.E；
The root of glycyrrhiza glabra and rhizomes is taken to clean, slice, drying to constant weight at 70 DEG C, and 10% ethyl alcohol is added and impregnates 2h, turmeric and second
Alcohol mass ratio is 4:1, takes out 50 DEG C of turmeric drying after impregnating, is crushed to 200 mesh, and the water that 5 times of quality are added carries out ultrasound and mentions
1h is taken, Extracting temperature is 30 DEG C, and filtrate is obtained after filtering to get glycyrrhiza glabra extract.
(2) by the proportion, by Queensland nut seed oil, Butyrospermum parkii fruit rouge, pentaerythrite four, (double-tert-butyl hydroxy is hydrogenated
Cinnamic acid) ester, glycerin polyether -26, tridecanol trimellitate, neopentyl glycol dicaprylate/dicaprate, 1,3- the third two
With the speed of 50r/min after alcohol, 1,2- pentanediol, Sodium Hyaluronate, Sensiva SC50, bisabolol and the mixing of tetrahydro piperine
It is cooling after degree stirring 5min, 80 DEG C of heating 10min, obtain feedstock oil phase；
(3) water, niacinamide, triethanolamine, EDETATE SODIUM are subjected to mixing by the proportion and are stirred with 50r/min speed
It is cooling after 5min, 90 DEG C of heating 10min, obtain raw material water phase；
(4) 50 DEG C are heated to after mixing the raw material water phase and feedstock oil, addition PEG-40 stearate, spermaceti are hard
Lipidol polyethers -20, stearine and cetostearyl alcohol homogeneous 70s；After cooling to 40 DEG C add dimethyl silicone polymer and
Esters of acrylic acid/C10-30 alkylol acrylamide acid esters cross-linked polymer homogeneous 50s；Continue to cool to 20 DEG C, adds Turmeric P.E
With glycyrrhiza glabra extract, continue homogeneous 20s；PH to 6.5 is adjusted, irradiates 30min using 60Co-γ rays, bottling refrigeration is in 0
To get the replenishing water and preserving moisture freckle removing and whitening brightening cream in DEG C temperature.
Embodiment 2
The present embodiment provides a kind of replenishing water and preserving moisture freckle removing and whitening brightening cream, raw material components include:
70 parts by weight of water, 7 parts by weight of niacinamide, 1.5 parts by weight of triethanolamine, 0.8 parts by weight of EDETATE SODIUM, Queensland nut
Seed oil 4 parts by weight, 4 parts by weight of Butyrospermum parkii fruit rouge, 3 parts by weight of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate),
1.5 parts by weight of glycerin polyether -26,2 parts by weight of tridecanol trimellitate, neopentyl glycol dicaprylate/dicaprate 1.5
Parts by weight, 2 parts by weight of 1,3- propylene glycol, 0.8 parts by weight of 1,2- pentanediol, 4 parts by weight of Sodium Hyaluronate, Sensiva SC50
1.5 parts by weight, 1.0 parts by weight of bisabolol, 0.1 parts by weight of tetrahydro piperine, 3 parts by weight of PEG-40 stearate, spermaceti are hard
- 20 3 parts by weight of lipidol polyethers, 3 parts by weight of stearine, 3 parts by weight of cetostearyl alcohol, 1 weight of dimethyl silicone polymer
Part, esters of acrylic acid/1 parts by weight of C10-30 alkylol acrylamide acid esters cross-linked polymer, 7 parts by weight of Turmeric P.E, glycyrrhiza glabra
8 parts by weight of extract.
Further, the present embodiment provides the preparation method of the replenishing water and preserving moisture freckle removing and whitening brightening cream, include the following steps:
(1) preparation of Turmeric P.E and glycyrrhiza glabra extract: turmeric being cleaned, slice, and drying to constant weight at 70 DEG C,
40% ethyl alcohol is added and impregnates 6h, turmeric and ethyl alcohol mass ratio are 8:1, take out 50 DEG C of turmeric drying after impregnating, are crushed to 300
Mesh, the water that 10 times of quality are added carry out ultrasonic extraction 3h, and Extracting temperature is 40 DEG C, and filtrate is obtained after filtering, repeats to extract 3 times, close
And filtrate is up to Turmeric P.E；The root of glycyrrhiza glabra and rhizomes is taken to clean, slice, drying to constant weight at 90 DEG C, is added
30% ethyl alcohol impregnates 6h, and turmeric and ethyl alcohol mass ratio are 7:1, takes out 70 DEG C of turmeric drying after impregnating, is crushed to 300 mesh, adds
The water for entering 5-10 times of quality carries out ultrasonic extraction 3h, and Extracting temperature is 40 DEG C, and filtrate is obtained after filtering, repeats to extract 3 times, merges filter
Liquid is up to glycyrrhiza glabra extract.
(2) by the proportion, by Queensland nut seed oil, Butyrospermum parkii fruit rouge, pentaerythrite four, (double-tert-butyl hydroxy is hydrogenated
Cinnamic acid) ester, glycerin polyether -26, tridecanol trimellitate, neopentyl glycol dicaprylate/dicaprate, 1,3- the third two
With 100r/min's after alcohol, 1,2- pentanediol, Sodium Hyaluronate, Sensiva SC50, bisabolol and the mixing of tetrahydro piperine
Speed stirs 10min, and cooling after 90 DEG C of heating 15min obtains feedstock oil phase；
(3) water, niacinamide, triethanolamine, EDETATE SODIUM are subjected to mixing by the proportion and are stirred with 70r/min speed
It is cooling after 10min, 100 DEG C of heating 15min, obtain raw material water phase；
(4) 90 DEG C are heated to after mixing the raw material water phase and feedstock oil, addition PEG-40 stearate, spermaceti are hard
Lipidol polyethers -20, stearine and cetostearyl alcohol homogeneous 110s；After cooling to 50 DEG C add dimethyl silicone polymer and
Esters of acrylic acid/C10-30 alkylol acrylamide acid esters cross-linked polymer homogeneous 80s；Continue to cool to 30 DEG C, adds Turmeric P.E
With glycyrrhiza glabra extract, continue homogeneous 40s；PH to 7.5 is adjusted, irradiates 60min using 60Co-γ rays, bottling refrigeration is in 4
To get the replenishing water and preserving moisture freckle removing and whitening brightening cream in DEG C temperature.
Embodiment 3
The present embodiment provides a kind of replenishing water and preserving moisture freckle removing and whitening brightening cream, raw material components include:
75 parts by weight of water, 6 parts by weight of niacinamide, 1 parts by weight of triethanolamine, 0.6 parts by weight of EDETATE SODIUM, Queensland nut seed
It is oily 3 parts by weight, 3 parts by weight of Butyrospermum parkii fruit rouge, 2 parts by weight of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), sweet
Oily -26 1 parts by weight of polyethers, 1.5 parts by weight of tridecanol trimellitate, neopentyl glycol dicaprylate/1 weight of dicaprate
Part, 1.5 parts by weight of 1,3- propylene glycol, 0.6 parts by weight of 1,2- pentanediol, 3 parts by weight of Sodium Hyaluronate, 1 weight of Sensiva SC50
Measure part, 0.6 parts by weight of bisabolol, 0.06 parts by weight of tetrahydro piperine, 2 parts by weight of PEG-40 stearate, cetostearyl alcohol
2 parts by weight of polyethers -20,2 parts by weight of stearine, 2 parts by weight of cetostearyl alcohol, 0.8 weight of dimethyl silicone polymer
Part, esters of acrylic acid/0.8 parts by weight of C10-30 alkylol acrylamide acid esters cross-linked polymer, 6 parts by weight of Turmeric P.E, light fruit are sweet
Careless 6 parts by weight of extract.
Further, the present embodiment provides the preparation method of the replenishing water and preserving moisture freckle removing and whitening brightening cream, include the following steps:
(1) preparation of Turmeric P.E and glycyrrhiza glabra extract: turmeric being cleaned, slice, and drying to constant weight at 65 DEG C,
30% ethyl alcohol is added and impregnates 4h, turmeric and ethyl alcohol mass ratio are 6.5:1, take out 45 DEG C of turmeric drying after impregnating, are crushed to 250
Mesh, the water that 7 times of quality are added carry out ultrasonic extraction 2h, and Extracting temperature is 35 DEG C, and filtrate is obtained after filtering, repeats to extract 2 times, merge
Filtrate is up to Turmeric P.E；The root of glycyrrhiza glabra and rhizomes is taken to clean, slice, drying to constant weight at 80 DEG C, is added 20%
Ethyl alcohol impregnates 4h, and turmeric and ethyl alcohol mass ratio are 6.5:1, takes out 60 DEG C of turmeric drying after impregnating, is crushed to 250 mesh, is added 7
The water of times quality carries out ultrasonic extraction 2h, and Extracting temperature is 35 DEG C, after filtering filtrate, repeat to extract 2 times, merging filtrate to obtain the final product
Glycyrrhiza glabra extract.
(2) by the proportion, by Queensland nut seed oil, Butyrospermum parkii fruit rouge, pentaerythrite four, (double-tert-butyl hydroxy is hydrogenated
Cinnamic acid) ester, glycerin polyether -26, tridecanol trimellitate, neopentyl glycol dicaprylate/dicaprate, 1,3- the third two
With the speed of 80r/min after alcohol, 1,2- pentanediol, Sodium Hyaluronate, Sensiva SC50, bisabolol and the mixing of tetrahydro piperine
It is cooling after degree stirring 7min, 85 DEG C of heating 13min, obtain feedstock oil phase；
(3) water, niacinamide, triethanolamine, EDETATE SODIUM are subjected to mixing by the proportion and are stirred with 60r/min speed
It is cooling after 7min, 95 DEG C of heating 13min, obtain raw material water phase；
(4) 70 DEG C are heated to after mixing the raw material water phase and feedstock oil, addition PEG-40 stearate, spermaceti are hard
Lipidol polyethers -20, stearine and cetostearyl alcohol homogeneous 90s；After cooling to 45 DEG C add dimethyl silicone polymer and
Esters of acrylic acid/C10-30 alkylol acrylamide acid esters cross-linked polymer homogeneous 65s；Continue to cool to 25 DEG C, adds Turmeric P.E
With glycyrrhiza glabra extract, continue homogeneous 30s；PH to 7 is adjusted, irradiates 45min using 60Co-γ rays, bottling refrigeration is in 2 DEG C
To get the replenishing water and preserving moisture freckle removing and whitening brightening cream in temperature.
Comparative example 1
The present embodiment provides a kind of replenishing water and preserving moisture freckle removing and whitening brightening cream, raw material components include:
75 parts by weight of water, 6 parts by weight of niacinamide, 1 parts by weight of triethanolamine, 0.6 parts by weight of EDETATE SODIUM, Queensland nut seed
It is oily 3 parts by weight, 3 parts by weight of Butyrospermum parkii fruit rouge, 2 parts by weight of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), sweet
Oily -26 1 parts by weight of polyethers, 1.5 parts by weight of tridecanol trimellitate, neopentyl glycol dicaprylate/1 weight of dicaprate
Part, 1.5 parts by weight of 1,3- propylene glycol, 0.6 parts by weight of 1,2- pentanediol, 3 parts by weight of Sodium Hyaluronate, 1 weight of Sensiva SC50
Measure part, 0.6 parts by weight of bisabolol, 0.06 parts by weight of tetrahydro piperine, 2 parts by weight of PEG-40 stearate, cetostearyl alcohol
2 parts by weight of polyethers -20,2 parts by weight of stearine, 2 parts by weight of cetostearyl alcohol, 0.8 weight of dimethyl silicone polymer
Part, esters of acrylic acid/0.8 parts by weight of C10-30 alkylol acrylamide acid esters cross-linked polymer.
Further, the present embodiment provides the preparation method of the replenishing water and preserving moisture freckle removing and whitening brightening cream, include the following steps:
(1) by the proportion, by Queensland nut seed oil, Butyrospermum parkii fruit rouge, pentaerythrite four, (double-tert-butyl hydroxy is hydrogenated
Cinnamic acid) ester, glycerin polyether -26, tridecanol trimellitate, neopentyl glycol dicaprylate/dicaprate, 1,3- the third two
With the speed of 80r/min after alcohol, 1,2- pentanediol, Sodium Hyaluronate, Sensiva SC50, bisabolol and the mixing of tetrahydro piperine
It is cooling after degree stirring 7min, 85 DEG C of heating 13min, obtain feedstock oil phase；
(2) water, niacinamide, triethanolamine, EDETATE SODIUM are subjected to mixing by the proportion and are stirred with 60r/min speed
It is cooling after 7min, 95 DEG C of heating 13min, obtain raw material water phase；
(3) 70 DEG C are heated to after mixing the raw material water phase and feedstock oil, addition PEG-40 stearate, spermaceti are hard
Lipidol polyethers -20, stearine and cetostearyl alcohol homogeneous 90s；After cooling to 45 DEG C add dimethyl silicone polymer and
Esters of acrylic acid/C10-30 alkylol acrylamide acid esters cross-linked polymer homogeneous 65s；PH to 7 is adjusted, is irradiated using 60Co-γ rays
45min, bottling refrigeration is in 2 DEG C of temperature to get the replenishing water and preserving moisture freckle removing and whitening brightening cream.
Comparative example 2
The present embodiment provides a kind of replenishing water and preserving moisture freckle removing and whitening brightening cream, raw material components include:
75 parts by weight of water, 6 parts by weight of niacinamide, 1 parts by weight of triethanolamine, 0.6 parts by weight of EDETATE SODIUM, Queensland nut seed
It is oily 3 parts by weight, 3 parts by weight of Butyrospermum parkii fruit rouge, 2 parts by weight of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), sweet
Oily -26 1 parts by weight of polyethers, 1.5 parts by weight of tridecanol trimellitate, neopentyl glycol dicaprylate/1 weight of dicaprate
Part, 1.5 parts by weight of 1,3- propylene glycol, 0.6 parts by weight of 1,2- pentanediol, 3 parts by weight of Sodium Hyaluronate, 1 weight of Sensiva SC50
Measure part, 0.6 parts by weight of bisabolol, 0.06 parts by weight of tetrahydro piperine, 2 parts by weight of PEG-40 stearate, cetostearyl alcohol
2 parts by weight of polyethers -20,2 parts by weight of stearine, 2 parts by weight of cetostearyl alcohol, 0.8 weight of dimethyl silicone polymer
Part, esters of acrylic acid/0.8 parts by weight of C10-30 alkylol acrylamide acid esters cross-linked polymer, 6 parts by weight of glycyrrhiza glabra extract.
Further, the present embodiment provides the preparation method of the replenishing water and preserving moisture freckle removing and whitening brightening cream, include the following steps:
(1) preparation of glycyrrhiza glabra extract: taking the root of glycyrrhiza glabra and rhizomes to clean, slice, is dried at 80 DEG C
Constant weight is added 20% ethyl alcohol and impregnates 4h, and turmeric and ethyl alcohol mass ratio are 6.5:1, take out 60 DEG C of turmeric drying after impregnating, crush
To 250 mesh, the water that 7 times of quality are added carries out ultrasonic extraction 2h, and Extracting temperature is 35 DEG C, and filtrate is obtained after filtering, repeats to extract 2
Secondary, merging filtrate is up to glycyrrhiza glabra extract.
(2) by the proportion, by Queensland nut seed oil, Butyrospermum parkii fruit rouge, pentaerythrite four, (double-tert-butyl hydroxy is hydrogenated
Cinnamic acid) ester, glycerin polyether -26, tridecanol trimellitate, neopentyl glycol dicaprylate/dicaprate, 1,3- the third two
With the speed of 80r/min after alcohol, 1,2- pentanediol, Sodium Hyaluronate, Sensiva SC50, bisabolol and the mixing of tetrahydro piperine
It is cooling after degree stirring 7min, 85 DEG C of heating 13min, obtain feedstock oil phase；
(3) water, niacinamide, triethanolamine, EDETATE SODIUM are subjected to mixing by the proportion and are stirred with 60r/min speed
It is cooling after 7min, 95 DEG C of heating 13min, obtain raw material water phase；
(4) 70 DEG C are heated to after mixing the raw material water phase and feedstock oil, addition PEG-40 stearate, spermaceti are hard
Lipidol polyethers -20, stearine and cetostearyl alcohol homogeneous 90s；After cooling to 45 DEG C add dimethyl silicone polymer and
Esters of acrylic acid/C10-30 alkylol acrylamide acid esters cross-linked polymer homogeneous 65s；Continue to cool to 25 DEG C, addition glycyrrhiza glabra mentions
Object is taken, homogeneous 30s is continued；Adjust pH to 7, using 60Co-γ rays irradiate 45min, bottling refrigeration in 2 DEG C of temperature to get
The replenishing water and preserving moisture freckle removing and whitening brightening cream.
Comparative example 3
The present embodiment provides a kind of replenishing water and preserving moisture freckle removing and whitening brightening cream, raw material components include:
75 parts by weight of water, 6 parts by weight of niacinamide, 1 parts by weight of triethanolamine, 0.6 parts by weight of EDETATE SODIUM, Queensland nut seed
It is oily 3 parts by weight, 3 parts by weight of Butyrospermum parkii fruit rouge, 2 parts by weight of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), sweet
Oily -26 1 parts by weight of polyethers, 1.5 parts by weight of tridecanol trimellitate, neopentyl glycol dicaprylate/1 weight of dicaprate
Part, 1.5 parts by weight of 1,3- propylene glycol, 0.6 parts by weight of 1,2- pentanediol, 3 parts by weight of Sodium Hyaluronate, 1 weight of Sensiva SC50
Measure part, 0.6 parts by weight of bisabolol, 0.06 parts by weight of tetrahydro piperine, 2 parts by weight of PEG-40 stearate, cetostearyl alcohol
2 parts by weight of polyethers -20,2 parts by weight of stearine, 2 parts by weight of cetostearyl alcohol, 0.8 weight of dimethyl silicone polymer
Part, esters of acrylic acid/0.8 parts by weight of C10-30 alkylol acrylamide acid esters cross-linked polymer, 6 parts by weight of Turmeric P.E.
Further, the present embodiment provides the preparation method of the replenishing water and preserving moisture freckle removing and whitening brightening cream, include the following steps:
(1) preparation of Turmeric P.E: turmeric being cleaned, slice, and drying to constant weight at 65 DEG C, and 30% ethyl alcohol is added and impregnates
4h, turmeric and ethyl alcohol mass ratio are 6.5:1, take out 45 DEG C of turmeric drying after impregnating, are crushed to 250 mesh, 7 times of quality are added
Water carries out ultrasonic extraction 2h, and Extracting temperature is 35 DEG C, and filtrate is obtained after filtering, repeats to extract 2 times, and merging filtrate is up to turmeric extraction
Object.
(2) by the proportion, by Queensland nut seed oil, Butyrospermum parkii fruit rouge, pentaerythrite four, (double-tert-butyl hydroxy is hydrogenated
Cinnamic acid) ester, glycerin polyether -26, tridecanol trimellitate, neopentyl glycol dicaprylate/dicaprate, 1,3- the third two
With the speed of 80r/min after alcohol, 1,2- pentanediol, Sodium Hyaluronate, Sensiva SC50, bisabolol and the mixing of tetrahydro piperine
It is cooling after degree stirring 7min, 85 DEG C of heating 13min, obtain feedstock oil phase；
(3) water, niacinamide, triethanolamine, EDETATE SODIUM are subjected to mixing by the proportion and are stirred with 60r/min speed
It is cooling after 7min, 95 DEG C of heating 13min, obtain raw material water phase；
(4) 70 DEG C are heated to after mixing the raw material water phase and feedstock oil, addition PEG-40 stearate, spermaceti are hard
Lipidol polyethers -20, stearine and cetostearyl alcohol homogeneous 90s；After cooling to 45 DEG C add dimethyl silicone polymer and
Esters of acrylic acid/C10-30 alkylol acrylamide acid esters cross-linked polymer homogeneous 65s；Continue to cool to 25 DEG C, add Turmeric P.E,
Continue homogeneous 30s；PH to 7 is adjusted, irradiates 45min using 60Co-γ rays, bottling refrigeration is in 2 DEG C of temperature to get the benefit
Water moisturizing freckle removing and whitening brightening cream.Experimental example
One, the skin effect test of replenishing water and preserving moisture freckle removing and whitening brightening cream described in embodiment 3 and comparative example 1-3
By 224 it is low and deep with skin, obscure, dry skin, pore it is coarse, of all ages, gender is randomly divided into 4 groups,
Every group of 56 people, respectively experimental group and control group 1-3 (respectively correspond replenishing water and preserving moisture freckle removing and whitening skin lightening obtained by comparative example 1-3
Frost), allow subject that using corresponding test face cream, the skin condition situation of change of study subject is observed after three months respectively:
Experimental group: it allows study subject to use face cream of the present invention in daily morning and at night, observes study subject skin
The situation of change of state；
Control group 1-3: allowing study subject in daily morning and at night using face cream described in comparative example 1-3, it is tested right to observe
As the situation of change of skin condition；
After the various periods of time for approval, to improve substantially without improvement, slightly, improve, be obviously improved as 4 grades of evaluation criterions,
The skin condition variation of each group study subject is counted.The results are shown in Table 1:
1 test result of table
| Group | Substantially without improvement | Slightly improve | Improve | It is obviously improved | It is efficient |
| Experimental group | 1 | 2 | 10 | 43 | 98.2% |
| Control group 1 | 37 | 12 | 7 | 0 | 33.9% |
| Control group 2 | 29 | 8 | 12 | 7 | 48.2% |
| Control group 3 | 32 | 2 | 19 | 3 | 42.9% |
It can be seen from the above result that experimental group study subject skin condition result of variations is most obvious, illustrate that experimental group is tested right
As using face cream of the present invention, improving obviously occur in the states such as skin is low and deep, obscure, dry skin, pore are coarse,
Also the skin-care effect of face cream of the present invention is sufficiently demonstrated.
Two, the effect that measurement inhibits melanin to be formed
Four test groups are set, the 1. culture containing 5ppm Turmeric P.E and 5ppm glycyrrhiza glabra extract is respectively as follows:
Base；2. the culture medium containing 5ppm Turmeric P.E；3. the culture medium containing 5ppm glycyrrhiza glabra extract；4. containing
The culture medium of 5ppmDMSO.
By people's melanocytes HM3KO cell inoculation in the culture medium containing 10% N of embryo's serum subculture, reach
When forth generation, cell inoculation is cultivated in 12 orifice plates, culture medium culture accordingly comprising test component is added in every hole
Cell (as described in Table 1) replaces primary corresponding culture medium for every two days, when cell confluency is 80%-90%, purges cell,
It is dissolved in sodium hydroxide, measures the OD value of every hole cell, the melanin that respective sets can be obtained forms inhibiting rate (such as table 2
It is shown).
1 cell inoculation of table, 12 orifice plate layouts table
| / | A | B | C | D | E | F |
| 1 | / | ① | ② | ③ | ④ | / |
| 2 | / | ① | ② | ③ | ④ | / |
2 each group melanin of table forms inhibiting rate
As shown in 2 result of table, it can be assumed that, the use in conjunction of Turmeric P.E and glycyrrhiza glabra extract is to melanin
Inhibit that there is synergistic effect, inhibiting rate be significantly larger than be used alone a kind of component as a result, also demonstrating of the present invention match
The definite skin lightening result of side.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of replenishing water and preserving moisture freckle removing and whitening brightening cream, which is characterized in that raw material components include:
Water 70-80 parts by weight, niacinamide 5-7 parts by weight, triethanolamine 0.5-1.5 parts by weight, EDETATE SODIUM 0.2-0.8 weight
(double-tert-butyl hydroxy hydrogenates meat for part, Queensland nut seed oil 2-4 parts by weight, Butyrospermum parkii fruit rouge 2-4 parts by weight, pentaerythrite four
Cinnamic acid) ester 1-3 parts by weight, -26 0.5-1.5 parts by weight of glycerin polyether, tridecanol trimellitate 1-2 parts by weight, new penta 2
Alcohol dicaprylate/dicaprate 0.5-1.5 parts by weight, 1,3- propylene glycol 1-2 parts by weight, 1,2- pentanediol 0.3-0.8 parts by weight,
Sodium Hyaluronate 2-4 parts by weight, Sensiva SC50 0.5-1.5 parts by weight, bisabolol 0.2-1.0 parts by weight, tetrahydro pepper
Alkali 0.01-0.1 parts by weight, PEG-40 stearate 1-3 parts by weight, -20 1-3 parts by weight of ceteareth, glyceryl stearate
Acid esters 1-3 parts by weight, cetostearyl alcohol 1-3 parts by weight, dimethyl silicone polymer 0.5-1 parts by weight, esters of acrylic acid/C10-30
Alkylol acrylamide acid esters cross-linked polymer 0.5-1 parts by weight, Turmeric P.E 5-7 parts by weight, glycyrrhiza glabra extract 3-8 weight
Part.
2. replenishing water and preserving moisture freckle removing and whitening brightening cream according to claim 1, which is characterized in that raw material components include:
75 parts by weight of water, 6 parts by weight of niacinamide, 1 parts by weight of triethanolamine, 0.6 parts by weight of EDETATE SODIUM, Queensland nut seed oil 3
Parts by weight, 3 parts by weight of Butyrospermum parkii fruit rouge, 2 parts by weight of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), glycerol
1 parts by weight of polyethers -26,1.5 parts by weight of tridecanol trimellitate, neopentyl glycol dicaprylate/1 parts by weight of dicaprate,
1.5 parts by weight of 1,3- propylene glycol, 0.6 parts by weight of 1,2- pentanediol, 3 parts by weight of Sodium Hyaluronate, 1 weight of Sensiva SC50
Part, 0.6 parts by weight of bisabolol, 0.06 parts by weight of tetrahydro piperine, 2 parts by weight of PEG-40 stearate, cetostearyl alcohol are poly-
2 parts by weight of ether -20,2 parts by weight of stearine, 2 parts by weight of cetostearyl alcohol, 0.8 parts by weight of dimethyl silicone polymer,
Esters of acrylic acid/0.8 parts by weight of C10-30 alkylol acrylamide acid esters cross-linked polymer, 6 parts by weight of Turmeric P.E, glycyrrhiza glabra mention
Take 6 parts by weight of object.
3. replenishing water and preserving moisture freckle removing and whitening brightening cream according to claim 1, which is characterized in that the Turmeric P.E uses
Following method is prepared:
Turmeric is cleaned, slice, drying to constant weight at 60-70 DEG C, and 20%-40% ethyl alcohol is added and impregnates 2-6h, turmeric and ethyl alcohol
Mass ratio is (5-8): 1,40-50 DEG C of turmeric drying after impregnating is taken out, 200-300 mesh is crushed to, 5-10 times of quality is added
Water carries out ultrasonic extraction 1-3h, and Extracting temperature is 30-40 DEG C, and filtrate is obtained after filtering, repeats to extract 1-3 times, merging filtrate to obtain the final product
Turmeric P.E.
4. replenishing water and preserving moisture freckle removing and whitening brightening cream according to claim 1, which is characterized in that the glycyrrhiza glabra extract
It is prepared with the following method:
The root of glycyrrhiza glabra and rhizomes is taken to clean, slice, drying to constant weight at 70-90 DEG C, and 10%-30% ethyl alcohol is added and impregnates
2-6h, turmeric and ethyl alcohol mass ratio are (4-7): 1,50-70 DEG C of turmeric drying after impregnating is taken out, 200-300 mesh is crushed to, adds
The water for entering 5-10 times of quality carries out ultrasonic extraction 1-3h, and Extracting temperature is 30-40 DEG C, and filtrate is obtained after filtering, repeats to extract 1-3
Secondary, merging filtrate is up to glycyrrhiza glabra extract.
5. the preparation method of any one of the claim 1-4 replenishing water and preserving moisture freckle removing and whitening brightening cream, which is characterized in that including with
Lower step:
(1) it matches by described by Queensland nut seed oil, Butyrospermum parkii fruit rouge, the (double-tert-butyl hydroxy hydrocinnamoyl of pentaerythrite four
Acid) ester, glycerin polyether -26, tridecanol trimellitate, neopentyl glycol dicaprylate/dicaprate, 1,3- propylene glycol, 1,
It is stirred evenly after 2- pentanediol, Sodium Hyaluronate, Sensiva SC50, bisabolol and the mixing of tetrahydro piperine, it is cold after heating
But, feedstock oil phase is obtained；
(2) water, niacinamide, triethanolamine, EDETATE SODIUM be mixed and stirred for uniformly by the proportion, it is cooling after heating,
Obtain raw material water phase；
(3) it is heated after mixing the raw material water phase and feedstock oil, addition PEG-40 stearate, cetostearyl alcohol are poly-
Ether -20, stearine and cetostearyl alcohol carry out homogeneous, added after cooling dimethyl silicone polymer and esters of acrylic acid/
C10-30 alkylol acrylamide acid esters cross-linked polymer carries out homogeneous, adds Turmeric P.E after continuing cooling and glycyrrhiza glabra extracts
Object continues homogeneous, sterilizes after adjusting pH, and bottling refrigeration is to get the replenishing water and preserving moisture freckle removing and whitening brightening cream.
6. the preparation method of replenishing water and preserving moisture freckle removing and whitening brightening cream according to claim 5, which is characterized in that in step (1),
The mixing speed is 50-100r/min, and the mixing time is 5-10min；
The heating temperature is 80-90 DEG C, and the heating time is 10-15min.
7. the preparation method of replenishing water and preserving moisture freckle removing and whitening brightening cream according to claim 5, which is characterized in that in step (2),
Mixing speed is 50-70r/min, mixing time 5-10min；
The heating temperature is 90-100 DEG C, and the heating time is 10-15min.
8. the preparation method of replenishing water and preserving moisture freckle removing and whitening brightening cream according to claim 5, which is characterized in that in step (3),
The raw material water phase and feedstock oil are heated to 50-90 DEG C after mixing, add PEG-40 stearate, ceteareth-
20, stearine and cetostearyl alcohol homogeneous 70-110s.
9. the preparation method of replenishing water and preserving moisture freckle removing and whitening brightening cream according to claim 5, which is characterized in that in step (3),
Dimethyl silicone polymer is added after cooling to 40-50 DEG C and esters of acrylic acid/C10-30 alkylol acrylamide acid esters cross-linked polymer is equal
Matter 50-80s is continued thereafter with and is cooled to 20-30 DEG C of addition Turmeric P.E and glycyrrhiza glabra extract, homogeneous 20-40s.
10. the preparation method of replenishing water and preserving moisture freckle removing and whitening brightening cream according to claim 5, which is characterized in that step (3)
In, the pH is adjusted to 6.5-7.5；It is carried out disinfection using 60Co-γ rays irradiation 30-60min；It refrigerates in 0-4 DEG C of temperature.
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| CN105997642A (en) * | 2016-06-16 | 2016-10-12 | 成都荣乐化妆品有限公司 | Skin confidante cream and preparation method thereof |
| CN106361620A (en) * | 2016-11-28 | 2017-02-01 | 宁浩 | Skin whitening cream |
| CN108014043A (en) * | 2017-12-15 | 2018-05-11 | 广东盛美化妆品有限公司 | A kind of maintenance frost of the Herba Dendrobii extract containing iron sheet and preparation method thereof |
| CN108186545A (en) * | 2018-04-02 | 2018-06-22 | 佛山市芊茹化妆品有限公司 | A kind of acne-removing composition and its application in cosmetics |
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| CN111265423A (en) * | 2020-04-13 | 2020-06-12 | 北京悠悦百仕科技发展有限公司 | Essence with whitening effect and preparation method thereof |
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Application publication date: 20190705 |