CN109963549A

CN109963549A - The washing methods of liquid artificial tooth detergent composition, artificial tooth dishwashing kit and artificial tooth

Info

Publication number: CN109963549A
Application number: CN201780070722.6A
Authority: CN
Inventors: 北川千晴; 泷本悠菜; 堤康太
Original assignee: Lion Corp
Current assignee: Lion Corp
Priority date: 2016-11-30
Filing date: 2017-11-30
Publication date: 2019-07-02
Also published as: KR20190089841A; WO2018101392A1

Abstract

As first invention, a kind of liquid artificial tooth detergent composition is provided, which is characterized in that containing (A) hydroxyethane diphosphonic acid and (B) surfactant, the pH at 20 DEG C of the composition is 5~9；As the second invention, a kind of liquid artificial tooth detergent composition is provided, which is characterized in that be concentrated type preparation containing (A) hydroxyethane diphosphonic acid, (B) surfactant and (C) benzoic acid or derivatives thereof；And invented as third, provide a kind of liquid artificial tooth detergent composition, which is characterized in that be the concentrated type preparation that the viscosity at 25 DEG C is 20~100mPas containing (B) surfactant and (E) thickener.The present invention can provide the liquid artificial tooth detergent composition of the color spot greasiness removal excellent effect of artificial tooth.

Description

The washing methods of liquid artificial tooth detergent composition, artificial tooth dishwashing kit and artificial tooth

Technical field

The present invention relates to a kind of liquid artificial tooth detergent composition of the color spot greasiness removal excellent effect of artificial tooth, use this The artificial tooth dishwashing kit of composition and the washing methods of artificial tooth.

Background technique

The spot for being attached to artificial tooth is denture plaque, swill, color spot (coloring deposit), calculus dentalis etc..In addition, having Report is pointed out: although denture plaque is constituted with microorganism seen in common plaque and structure is similar, it is more difficult to sterilize Candida albicans (Candida albicans) composition ratio be higher than plaque.

In order to wash these artificial tooth spots, carries out the scrub of artificial tooth, using the washing of artificial tooth detergent, also have and carry out the two Situation.It is not only the tooth of artificial tooth, and the part of its jaw mucous membrane, gum is also manufactured by resin, metal, therefore, spot object Area it is big, spot be also easy to it is eye-catching, especially, from health, beauty from the viewpoint of, color spot does not also make us the attachment of artificial tooth Satisfied, the removal of color spot spot becomes the big target of artificial tooth detergent.But other than sialoprotein matter, in addition by The modification of the substances foreigns such as food, the color spot spot firm attachment of artificial tooth, accordingly, it is difficult to satisfactorily remove.

In the past, artificial tooth detergent used in the washing of artificial tooth is, will be molten as the solid detergent of principal component using peroxide In Xie Yushui, the effervescent tablet of foaming etc when dissolution, keeping property excellent operation is also easy, therefore is mainstream, for example, someone mentions Solid artificial tooth detergent (the patent text containing the organic acid plus carbonate and surfactant to foam by acid-base reaction is gone out Offer 1: Japanese Unexamined Patent Publication 11-181500 bulletin).

But above-mentioned such previous solid type detergent, it is usually individually packed as unit of 1 secondary amounts, such as part justice Tooth not can be carried out the adjusting of usage amount, so causing user not when artificial tooth size has big difference because of people in this wise more It is full.It is also difficult to say in the concentration range of setting and be based only upon the chemical washing of dipping, washing force is the adequately short time Interior color spot greasiness removal effect is low.In addition, the worry that peroxide not only has artificial tooth to deteriorate, furthermore it is assumed that being soaked with high concentration Stain also has a possibility that artificial tooth metal discoloration when washing.

Then, the artificial tooth Installation Modes of partial denture setter are diversified.Although only installing justice when needing daytime Tooth is mainstream in the user removed during sleep, but the artificial tooth user for also continuing to install artificial tooth during sleep is also increasing.This The artificial tooth user of sample also installed during sleep, such as more brush in the morning wash artificial tooth when retaining tooth, it is therefore desirable to than previous One Dinner shorter time of dipping in the means that can wash.It is used as the artificial tooth washing within short time such as 15 minutes Preparation, liquid preparation is more advantageous than needing previous tablet, the powder agent of the dissolution time of preparation in water, at this point, using The artificial tooth washing of succinct washer is effective.However, it is very difficult to which the color spot for satisfactorily removing artificial tooth with liquid preparation is dirty Stain.

Consider from these angles, it is thus proposed that be free of peroxide, bleaching agent, be readily applied to justice, do not need for a long time Wash time, in the form of blister provide artificial tooth detergent (patent document 2: Japanese Unexamined Patent Publication 2007-254471 bulletin).But It is that the technology is due to being comprising the water phase of about 50~99%w/w and the cream with the oily phase of the non-miscibility of water of about 1~50%w/w Liquid, if will be separated using preceding do not rock, therefore the appearance stability in preservation is low, it is also difficult to maintain evenly effect.This Outside, the oily phase of the artificial tooth detergent is more, therefore, when brushing teeth suitable for artificial tooth, feels to the uncomfortable possibility such as stick-slip.Into One step, due to being free of bleach additive composition, the pH of cleaning solution is also low, therefore, even and if with brushing teeth, removal for color spot spot Power is also low.

It is desorbed in addition, proposing Candida albicans in patent document 3 (Japanese Unexamined Patent Application 63-14714 bulletin) from artificial tooth The high artificial tooth detergent composition comprising Water-soluble chitosan, chitosan class of ability.(the Japan of patent document 4~6 Special open 2008-179615 bulletin, special open 2010-6720 bulletin, special open 2011-241167 bulletin) in propose containing Specific surfactant, protease etc., the removal effect of artificial tooth biomembrane and the excellent concentrated type artificial tooth washing of bactericidal effect With liquid composition, propose in patent document 7 (Japanese Unexamined Patent Publication 6-183942 bulletin) containing peroxide and hydroxyl second Alkane di 2 ethylhexyl phosphonic acid, the bleaching of tobacco tar spot, removal effect excellent liquid artificial tooth detergent and artificial tooth washing methods, but its Color spot greasiness removal effect is unknown.In addition, patent document 8,9 (Japanese Unexamined Patent Publication 2010-168352 bulletin, Japanese Unexamined Patent Publication 2010- No. 280588 bulletins) in propose containing sulphite and specific surfactant, play the justice of color spot greasiness removal power Liquid composition is used in tooth washing.

Existing technical literature

Patent document

[patent document 1] Japanese Unexamined Patent Publication 11-181500 bulletin

[patent document 2] Japanese Unexamined Patent Publication 2007-254471 bulletin

[patent document 3] Japanese Unexamined Patent Application 63-14714 bulletin

[patent document 4] Japanese Unexamined Patent Publication 2008-179615 bulletin

[patent document 5] Japanese Unexamined Patent Publication 2010-6720 bulletin

[patent document 6] Japanese Unexamined Patent Publication 2011-241167 bulletin

[patent document 7] Japanese Unexamined Patent Publication 6-183942 bulletin

[patent document 8] Japanese Unexamined Patent Publication 2010-168352 bulletin

[patent document 9] Japanese Unexamined Patent Publication 2010-280588 bulletin

Summary of the invention

Subject to be solved by the invention

The present invention is in view of the foregoing, and it is an object of the present invention to provide the liquid artificial tooth of the color spot greasiness removal excellent effect of artificial tooth is washed Wash agent composition, using the artificial tooth dishwashing kit of the composition and the washing methods of artificial tooth.

The means to solve the problem

In order to achieve the above object, present inventor has performed further investigations, as a result, it has been found that, as first invention, group cooperation It for the hydroxyethane diphosphonic acid and surfactant of chelating agent, and is mixed into liquid artificial tooth detergent composition, is specific When pH range, the washing force for the color spot spot for being attached to artificial tooth is improved, color spot greasiness removal effect is especially excellent.

That is, in this first invention, by containing (A) hydroxyethane diphosphonic acid and (B) surfactant, the pH at 20 DEG C is 5~ 9, so as to obtain artificial tooth color spot greasiness removal excellent effect liquid artificial tooth detergent composition.

Color spot greasiness removal power based on chelating agent is insufficient, in addition, surfactants based color spot greasiness removal power Also insufficient, but in this first invention, when combining (A) and (B) ingredient, in the liquid preparation in the particular range of pH5 or more, Unexpectedly, two ingredients specifically and synergistically play a role, chemical washing and the effect for removing the color spot spot of artificial tooth Enhancing plays especially excellent color spot greasiness removal effect.Further, preparation through when uniformity reduce, fragrance component The separation of layer caused by separation etc., muddy and discoloration are suppressed, excellent storage stability, and assigning can by the rinsing of short period To inhibit good rinsability, the deterioration of deformation of artificial tooth after being also possible to prevent washing etc of the stick-slip sense, bitter taste of artificial tooth.

At this point, shown in Comparative Example I as be described hereinafter, (A) ingredient or (B) ingredient is used alone or and with the chela other than (A) ingredient When mixture and (B) ingredient, color spot removal rate is low.On the other hand, shown in embodiment I as be described hereinafter, in this first invention simultaneously When with (A) and (B) ingredient, imparting efficiently removes the color spot being firmly attached, excellent color spot greasiness removal effect.

In addition, the inventors discovered that, as the second invention, combine hydroxyethane diphosphonic acid, surfactant and benzoic acid Or derivatives thereof, and be diluted with water and mixed suitable for the concentrated type liquid artificial tooth detergent composition of artificial tooth when in use When, the color spot greasiness removal effect and bacteria-eliminating efficacy of artificial tooth are excellent, and usability is also good.

That is, passing through combination (A) hydroxyethane diphosphonic acid, (B) surfactant, especially alkyl amine oxide in this second invention (C) benzoic acid or derivatives thereof, and be mixed into concentrated type liquid artificial tooth detergent composition, to use water even when being applied Dilution, also plays high color spot greasiness removal power and Candida albicans sterilizing power, washing effect and bacteria-eliminating efficacy are excellent, in addition, especially It is easiness when preventing liquid when injection washer from hanging down drop (liquid hang down れ) and liquid splash and improving addition washer, It may insure good usability.

At this point, above three ingredient specifically interacts, and assigns especially significant work when combination (A), (B) and (C) ingredient Use effect.Especially, by excellent (B) ingredient of Candida albicans bactericidal effect and with (A) ingredient, to enhance chemistry Property the effect of color spot greasiness removal, thus, it is possible to have both the Candida albicans that continued proportion other oral cavity bacteriums are more difficult to sterilization The excellent bacteria-eliminating efficacy of sterilization, and the especially excellent washing that the color spot spot that is firmly attached also efficiently removes are imitated Fruit.Further, especially (C) ingredient and (B) ingredient and used time, the viscosity-adjusting agent moderately thickened is played unexpectedly and is made With, drop and liquid splash thus, it is possible to which liquid when preventing from putting into washer hangs down are easy to be added in washer, moreover, at The viscosity of the appropriateness dissolved can be promptly dispersed in water when dilution, even if not adding the viscosity such as other thickeners Modifying ingredients, usability are also excellent.

In addition, the menthol as fragrance plays when further mixing (D) menthol in the combination of (A), (B) and (C) ingredient Appropriateness adjusts the effect beyond expection of viscosity, more improvement usability.

Further, it the inventors discovered that, is invented as third, combined surfactant and thickener are simultaneously mixed into concentration In type liquid artificial tooth detergent composition, as concentrated type, when being set in the low range of viscosities compared, especially with washing When washing the usability in the artificial tooth washing of device and dispersed excellent and dilution and washing, the color spot spot for playing artificial tooth is also removed Excellent washing effect.In addition, color spot greasiness removal effect more improves when further mixing hydroxyethane diphosphonic acid.

That is, in the invention of this third, combination (B) surfactant and (E) thickener, and it is mixed into concentrated type liquid artificial tooth detergent In composition, the viscosity at 25 DEG C is 20~100mPas, thus especially in the artificial tooth washing using ultrasonic washer, Excellent usability and dispersibility are had both, is easy to be added in washer, can be dispersed rapidly in cold water, moreover, with When diluted cleaning solution washs, the high washing effect that can chemically remove the color spot spot of artificial tooth can be assigned.Further, By mixing (A) hydroxyethane diphosphonic acid, color spot greasiness removal effect also can be more improved.

When being further described in detail, the liquid artificial tooth detergent composition that above-mentioned second invention and third invention are related to is suitable The concentrated type liquid artificial tooth detergent composition of suitable following washing methods: using washer, put into washer together with water and Dilution prepares cleaning solution, artificial tooth is impregnated in the cleaning solution and is washed.At this point, to use liquid artificial tooth detergent composition, Such as within 15 minutes, further can wash artificial tooth with 5 minutes or so short periods, it is preferable to use washer artificial tooth Dipping.It in addition to this, also can be more preferably in efficiency if reusing ultrasonic wave.But artificial tooth washer, especially artificial tooth Ultrasonic washer tends to more smaller than common more purpose ultrasonic washers, therefore, liquid is added into its sink When artificial tooth detergent composition, it is easy to generation and flies out to outside washer and the project of the usability such as liquid splash, on improving State unfavorable condition, it is believed that be configured to the liquid preparation of concentrated type and assign a degree of viscosity be effective.On the other hand, will When the liquid preparation of concentrated type is diluted with water, it is desirable that be promptly dispersed in water and dissolve, but for the improvement of usability And when assigning viscosity, the dispersibility in water when being particularly due to low temperature deteriorates, and therefore, it is difficult to have both dispersibility.In contrast Ground, concentrated type liquid artificial tooth detergent composition of the present invention unexpectedly, can be relatively low as concentrated type Viscosity specific range of viscosities in, assign excellent usability, have both good dispersibility.

In the present invention, even if not mixing usually used peroxide etc. in artificial tooth detergent, it can also obtain to justice The sufficient color spot greasiness removal effect of tooth, and washing effect is excellent.The following color spot spots of the washing effect also remove Especially excellent effect: being firmly adhered to the spot in artificial tooth face, also that is, being formed mainly due to sialoprotein matter in artificial tooth face The film for being referred to as mycoderm, due to by based on as internal environment of oral cavity saliva or the substances foreigns such as food repair Decorations, and the color spot spot being firmly attached.In addition it is also possible to be washed with being not concerned about artificial tooth deterioration.

In addition, containing hydrogen peroxide and hydroxyl second disclosed in patent document 7 (Japanese Unexamined Patent Publication 6-183942 bulletin) The pH of the liquid artificial tooth detergent of alkane di 2 ethylhexyl phosphonic acid is low, this is because the tobacco tar based on hydrogen peroxide and hydroxyethane diphosphonic acid The improvement of washing force.From patent document 7 not it is contemplated that, by assigning in the range of pH5 or more and with (A) and (B) ingredient The greasiness removal effect that firm color spot spot can also remove.

Therefore, the present invention provides following liquid artificial tooth detergent compositions, the artificial tooth dishwashing kit using the composition With the washing methods of artificial tooth.

(1) a kind of liquid artificial tooth detergent composition, which is characterized in that contain

(A) hydroxyethane diphosphonic acid, and

(B) surfactant,

PH at 20 DEG C of the composition is 5~9.

(2) the liquid artificial tooth detergent composition recorded according to (1), wherein (B) surfactant is selected from as follows It is (I) one kind or two or more in~(III),

(I) the both sexes table of the carbon atom number selected from alkyl is 12~18 alkyl amine oxide and betaine type amphoteric surfac-tant Face activating agent；

(II) selected from acyl group carbon atom number be 8~18 acyl amino hydrochlorate, carbon atom number be 8~18 alkyl sulfate and The anionic surfactant of the alpha-alkene sulfonate of carbon atom number 8~18；

(III) carbon atom number selected from alkyl is 12~20, the average addition molal quantity of ethylene oxide is 10~20 moles poly- The nonionic surface active agent of ethylene oxide rilanit special.

(3) the liquid artificial tooth detergent composition recorded according to (1) or (2), wherein the composition contains 0.05~5 matter Measure (A) ingredient of %, (B) ingredient of 0.1~10 mass %.

(4) the liquid artificial tooth detergent composition recorded according to any one of (1)~(3), wherein by quality ratio, (B)/(A) It is 0.06~50.

(5) a kind of liquid artificial tooth detergent composition, which is characterized in that contain

(A) hydroxyethane diphosphonic acid,

(B) surfactant, and

(C) benzoic acid or derivatives thereof,

The composition is concentrated type preparation.

(6) the liquid artificial tooth detergent composition recorded according to (5), wherein (B) surfactant is that the carbon atom number of alkyl is 12~18 alkyl amine oxide.

(7) the liquid artificial tooth detergent composition recorded according to (5) or (6), wherein the composition contains 0.5~5 mass % (A) ingredient, (B) ingredient of 1~10 mass %, 0.1~1 mass % (C) ingredient.

(8) the liquid artificial tooth detergent composition recorded according to any one of (5)~(7), wherein the composition also contains (D) menthol of 0.05~0.5 mass %.

(9) the liquid artificial tooth detergent composition recorded according to any one of (5)~(8), wherein at 25 DEG C of the composition Viscosity be 15~100mPas.

(10) a kind of liquid artificial tooth detergent composition, which is characterized in that contain

(B) surfactant, and

(E) thickener,

The composition is the concentrated type preparation that the viscosity at 25 DEG C is 20~100mPas.

(11) a kind of liquid artificial tooth detergent composition, which is characterized in that contain

(A) hydroxyethane diphosphonic acid,

(B) surfactant, and

(E) thickener,

(12) the liquid artificial tooth detergent composition recorded according to (10) or (11), wherein

(B) surfactant is one kind or two or more in (I) and (II) as follows,

(II) alkyl sulfate and carbon of the carbon atom number selected from acyl group is 8~18 acyl amino hydrochlorate, carbon atom number 8~18 The anionic surfactant of the alpha-alkene sulfonate of atomicity 8~18.

(13) the liquid artificial tooth detergent composition recorded according to any one of (10)~(12), wherein (E) thickener be selected from One kind or two or more anionic property water-soluble high-molecular compound in sodium alginate, sodium carboxymethylcellulose and xanthan gum.

(14) the liquid artificial tooth detergent composition recorded according to any one of (10)~(13), wherein the composition contains 1 (E) ingredient of (B) ingredient of~10 mass %, 0.1~5 mass %.

(15) the liquid artificial tooth detergent composition recorded according to (11), wherein the composition contains 0.5~10 mass %'s (A) ingredient.

(16) the liquid artificial tooth detergent composition that any one of (5)~(15) are recorded, to be washed when using by what is be diluted with water Wash the concentrated type liquid artificial tooth detergent composition that liquid is suitable for artificial tooth, wherein the multiple being diluted with water is 10~100 times dilute It releases, and the concentration of (B) ingredient in above-mentioned cleaning solution is 0.1 mass % or more.

(17) the liquid artificial tooth detergent composition recorded according to any one of (5)~(16), wherein 25 DEG C of the composition Under pH be 5~9.

(18) the liquid artificial tooth detergent composition recorded according to any one of (1)~(17), wherein the composition was free of Oxide.

(19) the liquid artificial tooth detergent composition recorded according to any one of (1)~(18), wherein the composition is ultrasound Wave washing is used.

(20) a kind of artificial tooth dishwashing kit, which is characterized in that have the liquid artificial tooth washing for recording any one of (5)~(17) Agent composition is accommodated in the concentrated type liquid artificial tooth detergent and artificial tooth washer of plastics bottle container, and the artificial tooth washer has Put into the sink of aforesaid liquid artificial tooth detergent composition and water.

(21) a kind of washing methods of artificial tooth, which is characterized in that put into (5)~(17) and appoint in the sink of artificial tooth washer Artificial tooth is impregnated into above-mentioned cleaning solution after preparing cleaning solution by the liquid artificial tooth detergent composition and water of one record, dilution In.

At this point, inventing as first invention, the second invention and third, following liquid artificial tooth detergent combinations can be provided Object etc..

First invention:

(1-1) a kind of liquid artificial tooth detergent composition, which is characterized in that contain

(A) hydroxyethane diphosphonic acid, and

(B) surfactant,

PH at 20 DEG C of the composition is 5~9.

Second invention:

(2-1) a kind of concentrated type liquid artificial tooth detergent composition, which is characterized in that contain

(A) hydroxyethane diphosphonic acid,

(B ') alkyl amine oxide, and

(C) benzoic acid or derivatives thereof.

The concentrated type liquid artificial tooth detergent composition that (2-2) is recorded according to (2-1), wherein the composition further contains (D) menthol of 0.05~0.5 mass %.

The concentrated type liquid artificial tooth detergent composition that (2-3) is recorded according to (2-1) or (2-2), wherein the 25 of the composition PH at DEG C is 5~6.5.

The concentrated type liquid artificial tooth detergent composition that (2-4) is recorded according to any one of (2-1)~(2-3), wherein described group Closing the viscosity at 25 DEG C of object is 15~100mPas.

Third invention:

(3-1) a kind of concentrated type liquid artificial tooth detergent composition, which is characterized in that the composition contains (B) surface-active Agent and (E) thickener, the viscosity at 25 DEG C of the composition is 20~100mPas.

The concentrated type liquid artificial tooth detergent composition that (3-2) is recorded according to (3-1), wherein the composition further contains (A) hydroxyethane diphosphonic acid.

A kind of (3-3) artificial tooth dishwashing kit, is made of liquid artificial tooth detergent and artificial tooth washer,

Liquid artificial tooth detergent is that the concentrated type liquid artificial tooth detergent composition that (3-1) or (3-2) is recorded is incorporated in and has Made of plastics bottle container with flexible container body portion and bore 5mm outlet mouth below,

The sink of the standby investment aforesaid liquid artificial tooth detergent composition and water of artificial tooth scrubber.

A kind of (3-4) washing methods of artificial tooth, which is characterized in that

Into the sink of artificial tooth washer put into (3-1) or (3-2) record concentrated type liquid artificial tooth detergent composition and Artificial tooth is impregnated in above-mentioned cleaning solution and washs after preparing cleaning solution by water, dilution.

Invention effect

This first invention can provide the liquid artificial tooth detergent composition of the color spot greasiness removal excellent effect of artificial tooth.

This second invention, which can provide, plays excellent washing effect and bacteria-eliminating efficacy and the excellent concentrated type liquid justice of usability Tooth detergent composition.

The invention of this third can provide especially using washer artificial tooth washing in usability and dispersibility it is excellent and have The concentrated type liquid artificial tooth detergent composition for the excellent washing effect for thering is the color spot spot of artificial tooth also to remove.

These liquid artificial tooth detergent compositions, by impregnating artificial tooth, so as to simply and readily within a short period of time Washing also can carry out the adjusting of usage amount according to the size of artificial tooth, such as be also applied for the partial denture when brush retains tooth Washing.In addition, artificial tooth metal will not be damaged because of washing.

Specific embodiment

Hereinafter, the present invention is described in further detail.The liquid artificial tooth detergent composition of this first invention, feature exist In range of the pH 5~9 containing (A) hydroxyethane diphosphonic acid and (B) surfactant, at 20 DEG C.Liquid artificial tooth washing Agent composition is suitable for artificial tooth by liquid form (be not blister in the form of).

From the point of view of color spot greasiness removal effect, the combined amount of (A) hydroxyethane diphosphonic acid (HEDP) is preferably group Close 0.05~5% whole (quality %, same as below) of object, more preferable 0.1~2%, further preferred 0.2~2%.Combined amount More, color spot greasiness removal effect is higher, but from the point of view of preparation stability, preferably only polyhybird.When greater than 5%, There is the case where storage stability of artificial tooth detergent deteriorates.

As (B) surfactant, anionic surfactant, amphoteric surfactant, nonionic can be used Surfactant, cationic surfactant, but preferred anionic surfactant, amphoteric surfactant.More preferably Surfactant it is as described below, from the point of view of color spot greasiness removal effect, it is living to be especially preferred as anionic surface Property agent acyl amino hydrochlorate, the alkyl amine oxide as amphoteric surfactant, wherein preferred sodium lauroyl glutamate, Lauryl dimethyl amine oxide.

In addition, surfactant can be used alone with a kind, or two or more combination can be made from the point of view of showing from effect With.

As anionic surfactant, can be used alkyl sulfate, alpha-alkene sulfonate, acyl amino hydrochlorate, Alkylphosphonic.Wherein, from the point of view of color spot greasiness removal power, the alkyl sulfate, carbon of preferably carbon atom number 8~18 are former The acyl amino hydrochlorate that the alpha-alkene sulfonate of subnumber 8~18, the carbon atom number of acyl group are 8~18, more preferable acylamino acid Salt.As salt, the alkali metal salts such as particular certain cancers, sylvite, particularly preferred sodium salt.

As the alkyl sulfate of carbon atom number 8~18, lauryl sulfate, myristoyl sulfate etc. can be enumerated, especially Its preferred lauryl sulfate.Specifically, the lauryl sulphur of Toho Chemical Industry Co., Ltd.'s system, BASF AG can be used The commercially available products such as sour sodium.

The preferred carbon atom number of alpha-alkene sulfonate is 8~18, particularly preferred 14~16.Wherein, preferred carbon atom number 14 alpha-alkene sulfonate, particularly preferred sodium salt (common name: tetradecene sodium sulfonate).Specifically, oral preparations can be used In workable commercially available product, such as Shi Wang special chemical Co., Ltd. manufacture trade name " K LIPOLAN PJ-400CJ (powder Body) " and " LIPOLAN LB-440 (liquid) ".

The carbon atom number of the acyl group of acyl amino hydrochlorate preferably 8~18, particularly preferred 12~16 can be enumerated with carbon original Acyl glutamate, acylaspartic acid salt, acyl sarcosinates, acyl taurine salt of the acyl group of subnumber etc..Specifically, may be used Enumerate lauroyl glutamate salt, myristoyl glutamate, lauroyl aspartate, lauroyl sarcosine salt, Lauroyl methyl tauride etc..Wherein, preferably as the acyl glutamate of acid acyl amino hydrochlorate, acyl group asparagus fern ammonia Hydrochlorate, particularly preferred acyl glutamate, particularly preferred lauroyl glutamate salt.As salt, preferred as alkali salt is especially excellent Select sodium salt.Specifically, the commercially available product of Asahi Chemical Corp's manufacture etc. can be used.

As amphoteric surfactant, alkyl amine oxide, betaine type amphoteric surfac-tant, particularly preferred alkane can be enumerated Base amine oxide.

As alkyl amine oxide, the alkyl two that the carbon atom number of alkyl is 12~18, particularly preferred 12~16 preferably can be used Methyl oxidation amine, it can be mentioned, for example lauryl dimethyl amine oxides etc..It specifically, can be with as lauryl dimethyl amine oxide The commercially available products such as the trade name " CADENAX DM12D-W " manufactured using Shi Wang special chemical Co., Ltd..

As betaine type amphoteric surfac-tant, it can be mentioned, for example 2- alkyl-N- carboxymethyl-N- hydroxyethyl imidazole quinolines The fatty acid amide propyls glycine betaines such as glycine betaine, fatty acid distribution of coconut oil amido propyl betaine；Lauryl dimethyl amion acetic acid sweet tea Dish alkali etc., wherein preferred 2- alkyl-N- carboxymethyl-N- hydroxyethyl imidazole quinoline glycine betaine, fatty acid amide propyl glycine betaine, Particularly preferred fatty acid amide propyl glycine betaine.

As 2- alkyl-N- carboxymethyl-N- hydroxyethyl imidazole quinoline glycine betaine, can be used as trade name ENAGICOL C- 2- Cocoalkyl-N- carboxymethyl-N- hydroxyethyl imidazole quinoline glycine betaine sodium the water that 40H is sold by Shi Wang special chemical Co., Ltd. The conduct fatty acid distribution of coconut oil amido propyl of Degussa company manufacture can be used as fatty acid amide propyl glycine betaine in solution TEGO BETAIN CK, LEBON 2000 of Sanyo Chemical Industries, Ltd.'s manufacture of glycine betaine etc..

As nonionic surfactant, preferably polyethylene glycol type, particularly preferred polyoxyethylene alkyl ether and polyoxy second Alkene rilanit special.It is highly preferred that the carbon atom number that alkyl can be used is the average addition molal quantity of 12~20, ethylene oxide (hereinafter referred to as E.O. addition molal quantity.) be 10~20 moles polyoxyethylene alkyl ethers and/or E.O. addition molal quantity be 5 ~60 moles of Crodaret.

As polyoxyethylene alkyl ether, it can be mentioned, for example EMALEX HC-60, EMALEX HC-100 (Nihon Emulsion Co., Ltd. is manufactured)；BLAUNON SR-705,707 (manufactures of green wood oil rouge Industry Co., Ltd) etc..

As Crodaret, it can be mentioned, for example NIKKOL HCO-5, HCO-10, HCO-20, HCO-30 are (solar Learn Co., Ltd.'s manufacture)；BLAUNON RCW-20OR (manufacture of green wood oil rouge Industry Co., Ltd) etc..

It, can Exemplary alkyl radicals (carbon atom number 6~20) leptodactyline, dialkyl group (carbon as cationic surfactant Atomicity 6~20) quaternary ammonium salts such as dimethyl ammonium and alkyl (carbon atom number 6~20) dimethyl benzyl ammonium salt；Alkyl (carbon atom Number 6~20) amine salt；Alkyl (carbon atom number 6~20) amine ethylene oxide adduct；Fixanol etc..

(B) combined amount of surfactant is preferably whole 0.1~10%, more preferable 0.2~6% of composition.? When 0.1% or more, color spot greasiness removal effect is sufficiently excellent, when below 10%, can obtain abundant and appropriate rinsability. When greater than 10%, there is such situation: being difficult to remove stick-slip sense even if being rinsed after washing artificial tooth with water, or when installation artificial tooth Feel bitter taste.

In addition, each surfactant can be used in the range of the combined amount of above-mentioned (B) ingredient.

In this first invention, by quality ratio, indicate that (B)/(A) of the mixed proportion of (A) ingredient and (B) ingredient is preferred 0.06~50, more preferable 0.15~25.When in the range, color spot greasiness removal effect is more excellent, further the guarantor of preparation It is also excellent to deposit stability.(B)/(A) has the situation of the storage stability difference of artificial tooth detergent less than 0.06 or when being greater than 50.

It can according to need, mixed in addition to the above ingredients in the liquid artificial tooth detergent composition of this first invention Other known ingredients.For example, fragrance, solvent, colorant, fungicide etc. can be enumerated.

As fragrance, can with amount commonly using spearmint oil, Fructus Piperis peppermint oil (peppermint oil), fennel oil, Eucalyptus oil, wintergreen, cinnamon oil, caryophyllus oil, hundred inner careless oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, Yuan Sui oil, mandarin oil, limette oil (lime oil), lavender oil, rosemary oil, oreodaphene (laurel oil), oil of chamomile (chamomile oil), caraway seed oil (caraway oil), marjoram oil (marjoram oil), laurel, lemon grass (Cymbopogon citratus) The natural perfume materials such as oil, origanum oil, pinke needle oil, cassia oil and menthol, menthones, carvol, ethyl butyrate, vanillic aldehyde, ethyl Maltol, anethole, gaultherolin, cinnamic acid, Cineole, eugenol, ethyl vanillin, maltol, limonene, lemongrass Alcohol, linalool, bergamio, menthyl acetate, firpene, octanal, citral, pulegone (pulegone), acetic acid are fragrant The single-items fragrance such as celery ester, anisaldehyde, oleoresin ginger, creosol, dl- camphor further also include ethyl acetate, allyl Hexamethylene propionic ester, methyl anthranilate, methyl phenyl ethyl glycidate, undecalactone, hexanal, ethyl alcohol, propyl alcohol, Known fragrance used in the oral preparations such as the various compounding fragrances of the single-items such as butanol, isoamyl alcohol fragrance and/or natural perfume material.

5~20% or so polyalcohol etc. can also be added usually using water (ion exchange water) as solvent.

As colorant, can enumerate Amaranth, No. 3 red, No. 225 red, No. 226 red, yellow 4, Sunset Yellow FCF, The legal pigments such as yellow 205, blue 1, blue 2, blue 201, blue 204, green 3；Caramel colorant；Safflower Pigment；Gardenin；Cochineal color；Bixin；Mica titanium；Titanium oxide etc..

As fungicide, the nonionics fungicide such as isopropyl methyl phenol can be enumerated.Do not interfering effect of the invention In the range of, combined amount is effective quantity.

In addition, especially from the point of view of the deterioration for preventing artificial tooth, not mixing (combined amount 0%) conduct preferably in the present invention The peroxide such as the usually used SODIUM PERCARBONATE of artificial tooth detergent ingredients, sodium perborate；The oxygen such as hypochlorous acid or its salt, sulphite Agent, bleaching agent.When mixing, each combined amount preferably 0.03% is hereinafter, particularly preferred 0.01% or less.

PH of the liquid artificial tooth detergent composition of this first invention at 20 DEG C is 5~9, preferably 5.3~8.PH is less than 5 When, color spot greasiness removal effect is poor, in addition, by adverse effects such as the deformations of the artificial tooth due to caused by washing.PH is 9 or more When, the storage stability of preparation deteriorates.

PH can be it is unadjusted, can also add pH adjusting agent adjusting.As pH adjusting agent, sodium hydroxide, hydrogen-oxygen can be enumerated Change potassium, hydrochloric acid, phosphoric acid or its salt, citric acid or its salt, sodium carbonate, carbonated water element sodium, boric acid or its salt etc..

The liquid artificial tooth detergent composition that this first invention can be used with usual way, can not also diluent liquid Artificial tooth detergent composition directly uses, but also can according to need and use as concentrated type preparation.Also i.e., it is possible to dilute with water Artificial tooth is impregnated in dilution after releasing liquid artificial tooth detergent composition and is used, and after can also impregnating, washing, is used as needed Water is rinsed and is used.In addition, at this point, dipping artificial tooth when, it is desirable to (A) ingredient, (B) ingredient use concentration respectively with it is above-mentioned mix In the identical range of resultant range, within the above range, the dilution met in terms of these is suitable to preferably pH.

When being made into concentrated type, from the point of view of usability and dissolubility, the multiple being diluted with water is 10~100 times of composition Dilution, when especially 10~50 times dilutions, preferred design formulation concentrations so that (A) ingredient, (B) ingredient concentration respectively above-mentioned Using in concentration range.Furthermore it is preferred that so that pH when diluting is designed within the above range.For example, being formulated as in preparation (A) concentration of ingredient is 5% hereinafter, especially 2% hereinafter, the concentration of (B) ingredient is 10% hereinafter, especially 5% is below Concentrated type preparation, when use can be designed as: the concentration of (A) ingredient in the aqueous solution after dilution is 0.05% or more, especially It is 0.1% or more, the concentration of (B) ingredient is 0.1% or more, especially 0.2% or more.

The dip time of artificial tooth is preferably set to 5 minutes or more, is more preferably set as 10 minutes or more, the upper limit of dip time without It is particularly limited to, but within generally preferable 8 hours, within particularly preferred 6 hours.In addition, if lightly making spot de- with toothbrush etc. Fall behind, impregnates artificial tooth using liquid artificial tooth detergent composition of the invention, then more effectively.In addition, the combination of this first invention Object be it is liquid, dispersibility is high, therefore, even and if washed with well known ultrasonic washer, it is also possible, at this point, adopted Within the dip time of tooth preferably 15 minutes, particularly preferred 5 minutes or so.Further, using toothbrush, ultrasonic washing etc. When, it can also more effectively remove artificial tooth spot.

The concentrated type liquid detergent composition of this second invention contain above-mentioned (A) and (B) ingredient and (C) benzoic acid or Its derivative.

At this point, in this second invention, the details such as combined amount, type of (B) ingredient of (A) ingredient are respectively with above-mentioned the One invention is identical, but, from Candida albicans sterilizing power it is excellent from the point of view of, (B) surfactant preferably (B ') alkyl oxidation Amine, the alkyl amine oxide that the carbon atom number of more preferable alkyl is 12~18.In addition, the combined amount of (B) ingredient is preferably composition Whole 1~10%, particularly preferred 3~10%.When combined amount is 1% or more, sufficient Candida albicans bactericidal effect is obtained With color spot greasiness removal effect.When combined amount is 10% or less, the cryo-conservation stability of preparation can be well maintained.

It is identical as this first invention about (B)/(A) of expression (A) ingredient and the mixed proportion of (B) ingredient.

(C) benzoic acid or derivatives thereof is used in combination especially by with (B) ingredient, thus work as viscosity modifier, The viscosity of appropriateness is assigned, usability is improved, there is the vertical drop of no liquid and easily addition property when especially injecting washing container.

(C) benzoic acid or derivatives thereof is one kind or two or more in benzoic acid, benzoate and benzoic ether, especially excellent Select benzoate, particularly preferred sodium benzoate.

As the salt of benzoic acid, the alkali metal salts such as particular certain cancers, it can be mentioned, for example sodium benzoates etc..It, can as the ester of benzoic acid The ester with the alcohol of carbon atom number 1~5 is enumerated, it can be mentioned, for example methyl benzoate, ethyl benzoates etc..

From the point of view of usability raising, the 0.1 of the combined amount preferred composition entirety of (C) benzoic acid or derivatives thereof ~1%, more preferable 0.3~0.8%.When combined amount is 0.1% or more, become appropriate viscosity, fully improving usability (has Easiness when the vertical drop of no liquid, addition washing container).When combined amount is 1% or less, it can be well maintained and be diluted with water When dispersibility.

In addition, when the blending ratio of (B) ingredient and (C) ingredient is in particular range, becoming more appropriate in this second invention and gluing Degree, usability are excellent.By quality ratio, (B)/(C) preferably 1~100 of the mixed proportion of (B) ingredient and (C) ingredient is indicated, more It is preferred that 2~50.

In this second invention, (D) menthol is preferably further mixed as fragrance.And with mixing (C) benzoic acid or its spread out Biology and when (D) menthol, thickening property more improves, and viscosity becomes more appropriate, more improvement usability (have no liquid hang down drop, Easiness when washing container is added).

In addition, though the mechanism of action is unknown, still, thus it is speculated that the phenyl ring of the two can generate some effects and shadow to the improvement of usability It rings.

Menthol can be used as independent fragrance and directly use menthol, but also can be used such as peppermint oil, Fructus Piperis peppermint oil Essential oil etc. containing menthol.

In terms of menthol, the 0.05~0.5% of the combined amount preferred composition entirety of menthol.Combined amount is 0.05% or more When, fully improve usability, when below 0.5%, can successfully mix.

In addition, the concentrated type liquid detergent composition of this third invention be containing above-mentioned (B) ingredient and (E) thickener and Viscosity is in the composition of particular range, further preferably (A) ingredient.

In the invention of this third, the details such as kind of (B) ingredient are identical as above-mentioned first invention respectively, but, (B) ingredient 1~10%, especially the 3~10% of combined amount preferred composition entirety.It is dilute from fully obtaining when combined amount is 1% or more From the point of view of releasing multiple setting, washing force especially color spot greasiness removal effect is advantageous, when below 10%, system Storage stability in a low temperature of agent is sufficiently excellent.

As (E) thickener, water-soluble high-molecular compound can be mixed, but the angle of the viscosity stability from preparation is examined Consider, the water-soluble high-molecular compound of preferred anionic, particularly preferred sodium alginate, sodium carboxymethylcellulose, xanthan gum, In, from the viscosity stability of preparation and dispersibility, especially from the point of view of ultrasonic wave bring dispersibility, preferred alginic acid Sodium, sodium carboxymethylcellulose.These water-soluble high-molecular compounds, can be used alone, or two or more is applied in combination.

In addition, due to high-molecular compound and even if presence applies the case where agglutination of ultrasonic wave preparation becomes difficult to dispersion, this In three inventions, by using (E) ingredient, especially above-mentioned specific water-soluble high-molecular compound, so as to not cause this The agglutination of class, dispersibility deteriorate ground and adjust viscosity.

It can be so that the viscosity of composition becomes the viscosity at proper range, especially 25 DEG C and becomes 20~100mPas Ground adjusts the combined amount of (E) thickener, and suitably sets, but 0.1~5% range of preferably generally composition entirety, more Preferably 0.1~1%, further preferably 0.2~0.6%.When combined amount is 0.1% or more, it can assign abundant and appropriate Viscosity.When combined amount is 5% or less, viscosity is not too high or dosage form will not become paste or gel, but with liquid Form obtains effect of the invention.

In the invention of this third, chelating agent is preferably further mixed, particularly preferably mixes (A) hydroxyethane diphosphonic acid.Mixing When hydroxyethane diphosphonic acid, color spot greasiness removal effect is more improved.Its combined amount be preferably composition it is whole 0.5~ 10%, more preferable 3~5%.In addition, the mass ratio of (B)/(A) can be 0.1~20.

It can according to need in concentrated type liquid artificial tooth detergent composition of the present invention, mixing removes mentioned component Except other known ingredients.The details of known ingredient is identical as above-mentioned first invention.

In addition, in the second invention, when mixing (D) menthol, can be used in the range of the combined amount of (D) ingredient menthol, The fragrance such as spearmint oil, Fructus Piperis peppermint oil containing menthol.

In addition, when mixing (C) ingredient, it is (mixed that the viscosity-adjusting agents such as thickener in addition to this ingredient can not be mixed in the second invention Resultant 0%), such as when addition anionic property water-soluble high-molecular compound, combined amount can be 5% or less, it is particularly possible to It is 0.1~1%.

In third invention, when mixing (E) ingredient, the viscosity-adjusting agent ingredient (0%) other than (E) ingredient can not be mixed, it can also not Mix (C) benzoic acid or derivatives thereof.

It is viscous at 25 DEG C of concentrated type liquid artificial tooth detergent composition of the present invention from the point of view of usability Preferred 15mPas or more, particularly preferred 20mPas or more, particularly preferred 25mPas or more are spent, furthermore, it is possible to be 100mPas or less, it is particularly possible to be 80mPas hereinafter, specifically for 60mPas or less.

At this point, being examined in this second invention from the angle of usability (easiness when having the vertical drop of no liquid, washing container is added) Consider, the viscosity preferred 15mPas or more, particularly preferred 15~100mPas, more preferable 20~80mPas at 25 DEG C.? When 15mPas or more, it can more improve the vertical drop of liquid, further more improve easiness when washing container is added. In 100mPas or less, dispersibility when being diluted with cold water can be well maintained.

Viscosity in the invention of this third, from the point of view of the easiness (usability) and dispersibility that washer is added, at 25 DEG C For 20~100mPas, preferably 20~80mPas, more preferable 25~60mPas.When viscosity is less than 20mPas, addition is washed The easiness for washing device is poor.When greater than 100mPas, with the bad dispersibility of cold water, i.e., also do not dispersed using ultrasonic washing 5 minutes Yu Shuizhong will not be dissolved completely but remain.

It is (following with Brookfield viscometer (VISCOMETER TVB-10, Toki Sangyo Co., Ltd.'s manufacture) measurement viscosity in the present invention It is identical).

The pH of concentrated type liquid artificial tooth detergent composition can be with the liquid artificial tooth detergent of this above-mentioned first invention Composition is set in the same manner, from the viscosity for assigning appropriateness from the point of view of improving usability, pH (25 DEG C) can for 5~ 9, it is particularly possible to be 5~6.5.

At this point, pH (25 DEG C) can be 5~6.5 in this second invention.In the invention of this third, pH (25 DEG C) can be 5~9, especially It can be 5.3~8.It is preferred that within the above range by the pH design of the cleaning solution after dilution.It is not adjusted in addition, pH can be , but pH adjusting agent adjusting can also be added.

Concentrated type liquid artificial tooth detergent composition of the present invention is the concentrated type liquid preparation that dilution uses, and being can Dilution obtained by the dilution of the water such as tap water, purified water is used as cleaning solution, artificial tooth is impregnated in wherein, so as to wash The preparation of artificial tooth is preferably added to be used in washing in container.At this point, from the point of view of usability and dissolubility, concentrated type The multiple of liquid artificial tooth detergent composition being diluted with water can be 10~100 times of dilutions, it is particularly possible to dilute for 10~50 times It releases.

In the present invention, it can will be used using the diluted dilution of above-mentioned extension rate as artificial tooth maceration extract.At this point, dilution, That is, the preferred concentration of each ingredient in the cleaning solution after diluting is, the concentration of (B) ingredient is 0.1% or more, particularly preferably 0.15% or more, particularly preferably 0.2% or more.In addition, the preferred concentration of (A) ingredient is 0.05% or more, particularly preferably 0.1% or more.From the point of view of bactericidal effect, washing effect and usability, be more preferably diluted with water to make each concentration at It is used for concentration as described above.

In concentrated type liquid artificial tooth detergent composition, the washing methods of artificial tooth is, as long as using devoting artificial tooth washing In the dilution of above-mentioned concentration in container impregnate artificial tooth, in particular, dilution be it is liquid and dispersed also high, because This is, it is preferable to use and used the washer that can significantly improve the ultrasonic washing of its washing function.At this point, also can be used super Sound wave disperses blending constituent, carries out artificial tooth washing.After washing, artificial tooth can be taken out from washing in container, be rinsed with water After install.

In addition, the dip time of artificial tooth preferably 5 minutes or more, particularly preferred 10 minutes or more.The upper limit of dip time is without special It limits, but within generally preferable 8 hours, within particularly preferred 6 hours.In addition, carry out ultrasonic washing when, preferably 15 minutes with Under, particularly preferred 5 minutes or so.

The frequency of ultrasonic washing preferably 25~120kHz, more preferable 40~100kHz.Ultrasonic frequency above-mentioned lower limit value with When upper, sound when washing is small, furthermore, it is possible to the harmfulness such as deformation or rupture without artificial tooth washed.Ultrasonic frequency When below above-mentioned upper limit value, high washing force is obtained.In addition, power preferably 5~200W, more preferable 10~100W.Ultrasonic wave function When rate is more than above-mentioned lower limit value, high washing force is obtained.It, can be without the change of artificial tooth when ultrasonic power is below above-mentioned upper limit value Washed to the harmfulness such as shape or rupture.

In addition, as long as artificial tooth washer has and liquid preparation can be added impregnates the washing that artificial tooth is washed thereto The container of slot, can be used known containers.At this point, as long as the sink of artificial tooth washer is suitable for placement in the complete of artificial tooth The size of mouth artificial tooth or partial denture, is just not particularly limited, if succinct container, then because its usability (place to place) is good And it is preferred that.Specifically, from the point of view of being easy to be added concentrated type liquid artificial tooth detergent composition, usability, sink is Diameter or major diameter are 12cm round below or elliptical artificial tooth washer or are on one side at least 12cm below four The artificial tooth washer of side shape shape is suitable.The capacity of sink is 100~150ml or so.

The present invention concentrated type liquid artificial tooth detergent composition that especially third invention is related to can be accommodated in liquid system The general well known container of agent, it is desirable to such container: accommodating container main body has pliability, by from master Squeezed outside body with finger etc., so as to by the content stored (concentrated type liquid artificial tooth detergent composition) from the master Body portion discharge, be expelled in washer, such material, shape container be preferred.It is preferred that being for example accommodated in pliability The top of main part has in the plastics bottle container of the outlet mouth of 5mm bore below, at this point, the material of container body is suitable for For PET (polyethylene terephthalate), HDPE (high density polyethylene (HDPE)) etc..In addition, especially from the investment to washer Property from the point of view of, outlet mouth be bore be 5mm or less, preferably 0.5~5mm, more preferable 1~3mm outlet.

Embodiment

Hereinafter, showing embodiment and comparative example, prescription example, the present invention is illustrated, still, the present invention is not limited under State embodiment.In addition, unless otherwise specified, otherwise % indicates mass percent in following examples.

[embodiment I, Comparative Example I]

Liquid artificial tooth detergent composition with usual way with composition shown in tabulation 1~5, obtains artificial tooth cleaning solution.Will To artificial tooth cleaning solution be used as sample, evaluated according to method shown in following<experiment I>.As a result remember in table together.

In addition, adjusting pH with sodium hydroxide (NaOH), measured at 20 DEG C.

The main material used is as follows.

(A) hydroxyethane diphosphonic acid (HEDP):

Shi Wang special chemical Co., Ltd. manufactures (trade name: FELIOX 115-A)

(B) lauryl dimethyl amine oxide:

Shi Wang special chemical Co., Ltd. manufactures (trade name: CADENAX DM12D-W)

(B) sodium lauroyl glutamate:

Asahi Chemical Corp manufactures (trade name: Aminosurfact ALMS-P1)

(B) myristoyl glutamate sodium:

Asahi Chemical Corp manufactures (trade name: Aminosurfact AMMS-P1)

(B) lauroyl NaAsp:

Asahi Chemical Corp manufactures (trade name: AminoFoamer FLMS-P1)

(B) NaLS: Toho Chemical Industry Co., Ltd.'s manufacture

(B) fatty acid distribution of coconut oil amido propyl betaine (30% aqueous solution):

Sanyo Chemical Industries, Ltd. manufactures (trade name: LEBON 2000)

(B) polyoxyethylene (20) rilanit special

Nikko Chemicals Co., Ltd manufactures (trade name: NIKKOL HCO-20)

Ethylenediamine tetra-acetic acid (compares product)

Wako Pure Chemical Industries, Ltd.'s manufacture

Citric acid (compares product)

Wako Pure Chemical Industries, Ltd.'s manufacture

Test 1-1: the evaluation of color spot greasiness removal effect<1-1>

(1) it is attached with the production method of the acrylic panel 1 of tannin iron color spot

After blasting treatment acrylic panel surface (Kuraray Co., Ltd.'s manufacture, indulge 10mm × horizontal 10mm × thickness 5mm), adding Enter the ultrasonic washer (trade name: ultrasonic washer AU-80C, AIWA medical courses in general Industrial Co., Ltd manufacture) of neutral lotion In, it the used time 5 minutes, is rinsed and is washed with water.It after being repeated 3 times above-mentioned ultrasonic washing, spontaneously dries, measurement tannin iron color spot attachment The Lab value (L0) of preceding acrylic panel.For above-mentioned acrylic panel, according to 0.5% albumin aqueous solution → tannin extracting solution → The sequence of 0.6% ironic citrate (III) aqueous ammonium, repeat in them 3 times every time 30 minutes repeated impregnations operation, After air-drying 1 day at normal temperature, with water displacement wash, production coloring acrylic panel 1 is air-dried again.In addition, in the ion exchange of boiling Japan tea (Ito En Ltd.'s manufacture) 50g, black tea are added in 200mL for water 1 (Lipton company manufactures, Brisk Tea Bag) 5 bags, instant coffee (Nestle SA's manufacture, Nescafe) 12g, place a Dinner, are filtered to remove Japanese tea and black tea, make tannin Extracting solution.

The color on the surface of the coloring acrylic panel 1 of measurement production, taking its value is Lab value (L1).

(2) evaluation method of tannin iron color spot removal effect<1-1>

Artificial tooth cleaning solution about 50g as sample is added in beaker, be attached with tannin iron color spot third that above-mentioned (1) is made Olefin(e) acid plate 1 impregnates 5 minutes, and washing, the Lab value (L2) of the acrylic panel 1 after measurement is dry are rinsed under discharge condition.By with Under formula, acquire tannin iron color spot removal rate.

Tannin iron color spot removal rate (%)=((L1-L2)/(L1-L0)) × 100

(3) evaluation criterion of washing force

Color spot greasiness removal effect is evaluated according to evaluation criterion below according to tannin iron color spot removal rate.

Evaluation criterion

A: tannin iron color spot removal rate is 70% or more

B: tannin iron color spot removal rate is 60% more than and less than 70%

C: tannin iron color spot removal rate is 50% more than and less than 60%

D: tannin iron color spot removal rate is 30% more than and less than 50%

E: tannin iron color spot removal rate is less than 30%

Test 1-2: the evaluation of color spot greasiness removal effect<1-2>

(1) it is attached with the production method of the acrylic panel 2 (heavy colour blotchy stain) of tannin iron color spot

After blasting treatment acrylic panel surface (Kuraray Co., Ltd.'s manufacture, indulge 10mm × horizontal 10mm × thickness 5mm), adding Enter the ultrasonic washer (trade name: ultrasonic washer AU-80C, AIWA medical courses in general Industrial Co., Ltd manufacture) of neutral lotion In, it the used time 5 minutes, is rinsed and is washed with water.It after being repeated 3 times above-mentioned ultrasonic washing, spontaneously dries, measurement tannin iron color spot attachment The Lab value (L0) of preceding acrylic panel.For above-mentioned acrylic panel, according to 0.5% albumin aqueous solution → tannin extracting solution → The sequence of 0.6% ironic citrate (III) aqueous ammonium, repeat in them 10 times every time 30 minutes repeated impregnations behaviour Make, after air-drying 1 day at normal temperature, with water displacement wash, air-dries production coloring acrylic panel 2 again.In addition, the system of tannin extracting solution It is identical as experiment 1-1 to make method.

The color on the surface of the coloring acrylic panel 2 of measurement production, taking its value is Lab value (L1).

(2) evaluation method of tannin iron color spot removal effect<1-2>

After the sink of the injection ultrasonic washer of the artificial tooth cleaning solution about 130mL as sample, dipping is made in aforementioned manners Make the acrylic panel 2 for being attached with tannin iron color spot, carry out 5 minutes ultrasonic washing processing (frequency: 42kHz, power: 17W).After ultrasonic washing processing, washing, the Lab value (L2) of the acrylic panel 2 after measurement is dry are rinsed under discharge condition. According to formula below, tannin iron color spot removal rate is acquired.

Tannin iron color spot removal rate (%)=((L1-L2)/(L1-L0)) × 100

(3) evaluation criterion of washing force

The color spot greasiness removal effect of acrylic panel is evaluated according to evaluation criterion below according to tannin iron color spot removal rate.

Evaluation criterion

A: tannin iron color spot removal rate is 70% or more

B: tannin iron color spot removal rate is 50% more than and less than 70%

C: tannin iron color spot removal rate is 30% more than and less than 50%

D: tannin iron color spot removal rate is less than 30%

Further, for the liquid artificial tooth detergent composition of composition shown in table 1~4, also according to following experiments 2~ Method shown in 5 is evaluated.It is recorded result as the individual table below each table together.

Experiment 2: the evaluation of the storage stability of artificial tooth detergent

Artificial tooth cleaning solution about 78g as sample is packed into 80mL transparent PET container with cover, in low temperature (- 5 DEG C) condition Lower standing one-month period, returned after being saved according to following evaluation criterion evaluations appearance stability when warming to room temperature (uniformity The presence or absence of the presence or absence of the presence or absence of variation, sediment, layer separation, discoloration).

Evaluation criterion

A: uniformity, layer separation, muddy, in discoloration all items are showed no variation

B: observe that the project of any one of uniformity, layer separation, muddy, discoloration has the horizontal variation for not causing quality problems

C: observe that the project of any one of uniformity, layer separation, muddy, discoloration somewhat causes the variation of quality problems

D: observe that the project of any one of uniformity, layer separation, muddy, discoloration causes the horizontal variation of big quality problems

Experiment 3: the evaluation of the deformation of artificial tooth

Artificial tooth cleaning solution 48g as sample is packed into transparent glass container with cover, dipping is used as artificial tooth wherein The piece (vertical 20mm × horizontal 30mm × thickness 5mm) of acrylic resin (trade name: ACRON, GC manufacture) production of material, at 40 DEG C Under the conditions of, stand 1 month.Later, piece, after washing and drying, quality measurement are taken out.Initial stage quality and dipping before taking dipping respectively Quality that treated is M1, M2, and the deformation rate of artificial tooth is found out according to following formula.

Deformation rate (%)=(M1-M2)/M1 × 100 of artificial tooth

Evaluation criterion

A: the deformation rate of artificial tooth is less than 3%

B: the deformation rate of artificial tooth is 3% more than and less than 5%

C: the deformation rate of artificial tooth is 5% more than and less than 7%

D: the deformation rate of artificial tooth is 7% or more

Experiment 4: the evaluation of the stick-slip sense after rinsing

Artificial tooth detergent about 200mL as sample is added in 300mL glass beaker, at room temperature, by partial denture model (model: #D007 magnetic attachment (full maxilla), Co., Ltd. Quest manufacture) is impregnated in wherein 5 minutes.Later, part justice is taken out Tooth model, stick-slip sense when for rinsing under discharge condition, carries out sensory evaluation with following evaluation criterions.

Evaluation criterion

A: rinsing was unable to perceive that the stick-slip sense of artificial tooth less than 5 seconds

B: rinsing 5 seconds were unable to perceive that the stick-slip sense of artificial tooth more than and less than 10 seconds

C: rinsing 10 seconds were unable to perceive that the stick-slip sense of artificial tooth more than and less than 15 seconds

D: rinsing 15 seconds or more after 30 seconds or less, are unable to perceive that the stick-slip sense of artificial tooth

Experiment 5: the evaluation of bitter taste when installation

Artificial tooth detergent about 100mL as sample is added in 150mL glass beaker, at room temperature, by clear acrylic plate (Kuraray Co., Ltd., vertical 20mm × horizontal 30mm × thickness 2mm) is impregnated in wherein 5 minutes.Later, clear acrylic is taken out Plate is put into oral cavity after rinsing 10 seconds under discharge condition, for the bitter taste felt at this time, according to following evaluation criterions Carry out sensory evaluation.

Evaluation criterion

A: it totally can not feel bitter taste

B: bitter taste is hardly felt

C: feel a little bitter taste

D: feel strong bitter taste

[table 1]

[table 2]

[table 3]

[table 4]

*；The pure component amount of fatty acid distribution of coconut oil amido propyl betaine.

[table 5]

[embodiment II, Comparative Example I I]

Concentrated type liquid artificial tooth detergent composition with usual way with composition shown in tabulation 6,7, with following < experiment II > shown in method evaluated.As a result remember in table together.

In addition, adjusting pH (25 DEG C) with sodium hydroxide (NaOH).

The viscosity of composition is the value measured with following conditions.

Viscosimeter: VISCOMETER TVB-10 (Toki Sangyo Co., Ltd.'s manufacture)

Rotor model: M1

Revolving speed: 50rpm

Minute: 60 seconds

In addition, the artificial tooth detergent composition of embodiment II-1 is to be saved (1 month at 50 DEG C) change without physical property, save surely Qualitative excellent composition.

Experiment 1: the evaluation of bactericidal effect

(1) it is detected the preparation of bacterium solution

Candida albicans (Candida albicans ATCC10231) is seeded to Difco corporation Potato with platinum ring Dextrose Agar culture medium (PDA culture medium) is cultivated 24 hours at 25 DEG C, plays bacterium.Further, will be increased with platinum ring Colony inoculation after growing is cultivated before carrying out 48 hours at 25 DEG C to PDA culture medium.Bacterium colony after taking proliferation with platinum ring, matches Being formed in the turbidity after suspending in normal saline solution is OD_660nm=2.0.

(2) preparation of test sample

The concentrated type liquid artificial tooth detergent composition of preparation is diluted 20 times with water, detergent dilution is prepared, as sample It uses.

(3) to the evaluation method of the sterilizing power of Candida albicans

The tested bacterium solution 0.1mL that above-mentioned (1) is prepared is added in the detergent dilution 4mL for the sample prepared to above-mentioned (2), uses whirlpool After revolving mixer mixing, place 5 minutes at room temperature.Later, above-mentioned mixed liquor 0.444mL and Daigo company are manufactured SCDLP fluid nutrient medium 4mL mixing makes reaction inactivation (dilute 10 at this stage¹).Then, with 10 times of matrix manufacturing of inactivation culture Dilution series, respectively by the 10 of each 50 μ L¹、10³、10⁵Dilution is applied to PDA culture medium, after cultivating at 25 DEG C, to growth Clump count counted, calculate aerobic plate count.

According to obtained aerobic plate count, the sterilizing power to Candida albicans is determined according to following evaluation criterions.

To the evaluation criterion of the sterilizing power of Candida albicans

Under the action of A:5 minutes, log reduction 3Log₁₀More than

Under the action of B:5 minutes, log reduction is less than 3Log₁₀

Experiment 2: the evaluation to the washing effect of artificial tooth spot

Production is attached with the acrylic panel of tannin iron color spot in the same manner as the experiment 1-1 of above-mentioned<experiment I>, similarly measures Lab It is worth (L1).

The concentrated type liquid artificial tooth detergent composition of preparation is diluted 20 times with water, detergent dilution is prepared, as sample It uses, in addition to impregnating being attached with other than the acrylic panel of tannin iron color spot for production in above-mentioned detergent dilution 100mL, Tannin iron color spot removal rate is found out in the same manner as the experiment 1-1 of<experiment I>.

According to obtained tannin iron color spot removal rate, determine that color spot removes power according to following evaluation criterions.

The evaluation criterion of color spot removal power

A: 50% or more tannin iron color spot removal rate

B: tannin iron color spot removal rate 40% is more than and less than 50%

C: tannin iron color spot removal rate 30% is more than and less than 40%

D: tannin iron color spot removal rate is less than 30%

Experiment 3: the evaluation of usability (having easiness when the vertical drop of no liquid, addition washing container)

(1) preparation of test sample

The concentrated type liquid artificial tooth detergent composition (stoste) of preparation is used directly as detergent sample.

(2) evaluation method of usability

It is evaluated by the sensory test of 10 people of estimator.Plastic bottle container body filling to the PET of inner capacities 250mL Sample about 250mL, with the outlet of the hinge cap sealing bottle of the outlet with internal diameter 2mm.The single-hand handling & plastics bottle container The lid for removing hinge cap, from the outlet of internal diameter 2mm, by the sink of about 5g sample injection washing container, (diameter is about 7.5cm, depth about 5cm's is round), as usability at this time, there is the vertical drop of no liquid according to following evaluation criterion evaluations, adds Enter easiness when washing container.It is scattered in rapidly when in addition, the detergent of all embodiments is by injection washing container In water.

Herein, easiness when washing container is added refers to, reaches liquid when preventing investment and splashes to outside container.

There is the evaluation criterion of the vertical drop of no liquid

4 points: absolutely not liquid, which hangs down, drips

3 points: liquid hangs down drop on the side Gai Kou of hinged lid

2 points: liquid, which hangs down, drops to the hinged place of hinged lid

1 point: liquid, which hangs down, drops to bottle

The evaluation criterion of easiness when addition washing container

4 points: being very easy to be added

3 points: being readily incorporated into a little

2 points: a little difficult to be added

1 point: very difficult addition

For there is easiness when the vertical drop of no liquid, addition washing container, the evaluation result of 10 people is averaged, according to flat Mean value is evaluated according to following evaluation criterions.

A:3.5 points or more, 4.0 points or less

B:3.0 points more than and less than 3.5 points

C:2.0 points more than and less than 3.0 points

D: less than 2.0 point

The details of the main material used is as follows.

(A) hydroxyethane diphosphonic acid: Italmatch company manufactures (trade name: Dequest 2010)

(B) lauryl dimethyl amine oxide: Shi Wang special chemical Co., Ltd. manufactures (trade name: CADENAX DM12D-W)

(C) sodium benzoate: Fushimi Pharmaceutical Company, Limited manufactures (trade name: sodium benzoate)

(D) peppermint oil: menthol concentration 39%, the manufacture of Yan Ye fragrance Co., Ltd.

[table 6]

[table 7]

In addition, to the concentrated type liquid artificial tooth detergent composition of the embodiment II in table 6, with 2 phases of aftermentioned experiment Same method carries out the evaluation of dispersibility, and result is A evaluation, has good dispersibility.

[embodiment III, Comparative Example I II]

Concentrated type liquid artificial tooth detergent composition according to usual way with composition shown in tabulation 8,9, according to following < real Test III > shown in method evaluated.As a result remember in table together.

The viscosity of composition be it is following under conditions of the value that measures.

Viscosimeter: VISCOMETER TVB-10 (Toki Sangyo Co., Ltd.'s manufacture)

Rotor model: M1 (embodiment, comparative example 2), M2 (comparative example 1,3,4)

Revolving speed: 50rpm

Minute: 60 seconds

The main material used is as follows.

(B) lauryl dimethyl amine oxide:

Lion king's special chemical Co. Ltd. system (trade name: CADENAX DM12D-W)

(B) NaLS: BASF AG's system (trade name: Texapon OC-P)

(B) alpha-olefin sodium sulfonate:

Lion king's special chemical Co. Ltd. system (trade name: LIPOLAN LB-440)

Sanyo Chemical Industries, Ltd.'s system (trade name: LEBON 2000)

(E) sodium alginate: Co., Ltd.'s KIMICA system (trade name: KIMICA ALGIN)

(E) sodium carboxymethylcellulose:

Daisel chemical industry Co., Ltd's system (degree of etherification falling: 0.87~0.92)

(E) xanthan gum: Si Bikai can corporation (trade name: Monat Gum DA)

(A) hydroxyethane diphosphonic acid:

Italmatch company manufactures (trade name: Dequest 2010)

Experiment 1: the evaluation of usability (easiness that washer is added)

In the same manner as the experimental example 3 of the above embodiments II, uses concentrated type liquid artificial tooth detergent composition as sample, press According to same standard evaluate be added washer easiness, the evaluation result of 10 people is averaged, according to same standard into Row determines.Reach the composition judgement of the addition easiness of A and B are as follows: sink, the usability for being easy to be added washer are good Preparation.

Herein, easiness is added to refer to, flies out when investment is to sink to outside container, liquid splash is prevented from, do not pollute washing Around slot, the amount wanted to be added in sink is accurately added.

Experiment 2: dispersed evaluation

(1) preparation of test sample

Respectively in the concentrated type liquid artificial tooth detergent composition of preparation, blue 1 of 0.001%, colour generation are further added Blue uses it as sample.

(2) dispersed evaluation method

The sample of colour generation blue is accommodated in container identical with experimental example 1, similarly, about 5g sample injection ultrasonic wave is washed The sink (diameter 12cm's is roughly circular) of device is washed, after injecting the cold water that 130ml is saved at 0 DEG C, starts ultrasonic washing (frequency: 42kHz, power: 17W) is measured from starting to the absorbance (630nm) (A1) by cleaning solution after five minutes.Separately Outside, continue to be dissolved completely in cold water up to sample, measure the absorbance (A0) under dissolved state, asked according to following formula Dispersion rate is obtained, evaluates dispersibility according to following standards.

Dispersion rate (%)=A1/A0 × 100

Evaluation criterion

A: dispersion rate 100%

B: dispersion rate is 90% more than and less than 100%

C: dispersion rate is 80% more than and less than 90%

D: dispersion rate is less than 80%

Test 3-1: the evaluation of washing force<3-1>

The concentrated type liquid artificial tooth detergent composition of preparation is diluted to 20 times of washing dilution agent with ion exchange water by preparation Liquid uses the dilution as sample, and dipping production is attached with tannin iron color spot in Xiang Shangshu detergent dilution 130mL Acrylic panel finds out tannin iron color spot removal rate in the same manner as the experiment 1-1 of<experiment I>in addition to this.

According to tannin iron color spot removal rate, power is removed according to following evaluation criterion evaluation color spots.

The evaluation criterion of washing force

A: 60% or more tannin iron color spot removal rate

B: tannin iron color spot removal rate 50% is more than and less than 60%

C: tannin iron color spot removal rate 30% is more than and less than 50%

D: tannin iron color spot removal rate is less than 30%

Test 3-2: the evaluation of washing force<3-2>(ultrasonic washing)

Production is attached with the acrylic panel of tannin iron color spot in the same manner as the experiment 1-2 of above-mentioned<experiment I>, similarly measures Lab It is worth (L1).

Detergent after the concentrated type liquid artificial tooth detergent composition of preparation is diluted to 20 times with ion exchange water by preparation is dilute Liquid is released, uses the dilution as sample.

After the sink of washing force evaluation sample about 130ml injection ultrasonic washer, impregnate production is attached with tannin iron The acrylic panel of color spot, the ultrasonic washing carried out 5 minutes handle (frequency: 42kHz, power: 26W).Ultrasonic washing processing Afterwards, washing is rinsed under discharge condition, the Lab value (L2) of the acrylic panel after measurement is dry acquires list in the same manner as experiment 3-1 Peaceful iron color spot removal rate evaluates the color spot washing force of acrylic panel according to identical standard.

[table 8]

*: the amount of the pure ingredient of fatty acid distribution of coconut oil amido propyl betaine.

In addition, the extension rate in addition to making the No.1 of embodiment III, 14 concentrated type liquid artificial tooth detergent composition Other than 30 times, washing force is evaluated with method similar to the above, as a result washing force<3-1>is A, and washing force<3-2>is A.

[table 9]

Prescription example is shown below.It is same as described above using raw material.

[prescription example 1] liquid artificial tooth detergent

PH=6.0, (B)/(A)=2.0

[prescription example 2] liquid artificial tooth detergent

PH=6.0, (B)/(A)=1.5

[prescription example 3] liquid artificial tooth detergent

PH=6.0, (B)/(A)=0.5

[prescription example 4] liquid artificial tooth detergent

PH=6.0, (B)/(A)=2.0

[prescription example 5] liquid artificial tooth detergent

PH=6.0, (B)/(A)=1.5

[prescription example 6] liquid artificial tooth detergent

PH=6.0, (B)/(A)=0.5

[prescription example 7] concentrated type liquid artificial tooth detergent

(B)/(C)=12, (B)/(A)=2.0

PH (25 DEG C) 6, viscosity 35.3mPas

[prescription example 8] concentrated type liquid artificial tooth detergent

(B)/(C)=12, (B)/(A)=2.0

PH (25 DEG C) 6, viscosity 39.3mPas

[prescription example 9] concentrated type liquid artificial tooth detergent

(B)/(C)=12, (B)/(A)=2.0

PH (25 DEG C) 6, viscosity 46.1mPas.

Claims

1. a kind of liquid artificial tooth detergent composition, which is characterized in that contain

(A) hydroxyethane diphosphonic acid, and

(B) surfactant,

PH at 20 DEG C of the composition is 5~9.

2. liquid artificial tooth detergent composition according to claim 1, wherein (B) surfactant is selected from following institute It is one kind or two or more in (I) shown~(III),

(I) amphoteric surface of the carbon atom number selected from alkyl is 12~18 alkyl amine oxide and beet alkali ampholytic surface active agent Activating agent；

(II) selected from acyl group carbon atom number be 8~18 acyl amino hydrochlorate, carbon atom number be 8~18 alkyl sulfate and The anionic surfactant for the alpha-alkene sulfonate that carbon atom number is 8~18；

3. liquid artificial tooth detergent composition according to claim 1 or 2, wherein the composition contains 0.05~5 matter Measure (A) ingredient of %, (B) ingredient of 0.1~10 mass %.

4. liquid artificial tooth detergent composition described in any one of claim 1 to 3, wherein by quality ratio, (B)/ It (A) is 0.06~50.

5. a kind of liquid artificial tooth detergent composition, which is characterized in that contain

(A) hydroxyethane diphosphonic acid,

(B) surfactant, and

(C) benzoic acid or derivatives thereof,

The composition is concentrated type preparation.

6. liquid artificial tooth detergent composition according to claim 5, wherein (B) surfactant is that the carbon of alkyl is former Subnumber is 12~18 alkyl amine oxide.

7. liquid artificial tooth detergent composition according to claim 5 or 6, wherein the composition contains 0.5~5 matter Measure (C) ingredient of (A) ingredient of %, (B) ingredient of 1~10 mass %, 0.1~1 mass %.

8. the liquid artificial tooth detergent composition according to any one of claim 5~7, wherein the composition is into one (D) menthol of step ground containing 0.05~0.5 mass %.

9. the liquid artificial tooth detergent composition according to any one of claim 5~8, wherein the 25 of the composition Viscosity at DEG C is 15~100mPas.

10. a kind of liquid artificial tooth detergent composition, which is characterized in that contain

(B) surfactant, and

(E) thickener,

11. a kind of liquid artificial tooth detergent composition, which is characterized in that contain

(A) hydroxyethane diphosphonic acid,

(B) surfactant, and

(E) thickener,

12. liquid artificial tooth detergent composition described in 0 or 11 according to claim 1, wherein (B) surfactant be selected from It is one kind or two or more in (I) and (II) as follows,

(II) selected from acyl group carbon atom number be 8~18 acyl amino hydrochlorate, carbon atom number be 8~18 alkyl sulfate and The anionic surfactant for the alpha-alkene sulfonate that carbon atom number is 8~18.

13. liquid artificial tooth detergent composition described in any one of 0~12 according to claim 1, wherein (E) thickener is One kind or two or more anionic property water soluble polymer chemical combination in sodium alginate, sodium carboxymethylcellulose and xanthan gum Object.

14. liquid artificial tooth detergent composition described in any one of 0~13 according to claim 1, wherein the composition contains There are (B) ingredient of 1~10 mass %, (E) ingredient of 0.1~5 mass %.

15. liquid artificial tooth detergent composition according to claim 11, wherein the composition contains 0.5~10 matter Measure (A) ingredient of %.

16. the liquid artificial tooth detergent composition according to any one of claim 5~15, will be dilute with water when to use The cleaning solution released is suitable for the concentrated type liquid artificial tooth detergent composition of artificial tooth, and the multiple being diluted with water is 10~100 times dilute It releases, and the concentration of (B) ingredient in the cleaning solution is 0.1 mass % or more.

17. the liquid artificial tooth detergent composition according to any one of claim 5~16, wherein the composition PH at 25 DEG C is 5~9.

18. liquid artificial tooth detergent composition described according to claim 1~any one of 17, wherein the composition is not Containing peroxide.

19. liquid artificial tooth detergent composition described according to claim 1~any one of 18 is used for ultrasonic washing.

20. a kind of artificial tooth dishwashing kit, which is characterized in that have liquid artificial tooth described in any one of claim 5~17 Detergent composition is accommodated in concentrated type liquid artificial tooth detergent made of plastics bottle container and has and washes for the liquid artificial tooth Wash the artificial tooth washer of the sink of agent composition and water investment.

21. a kind of washing methods of artificial tooth, which is characterized in that put into claim 5~17 into the sink of artificial tooth washer Any one of described in liquid artificial tooth detergent composition and water, dilution, prepare cleaning solution after, artificial tooth is impregnated in the washing In liquid.