CN109954051A - A kind of Chinese materia medica preparation for treating cataract - Google Patents
A kind of Chinese materia medica preparation for treating cataract Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/12—Ophthalmic agents for cataracts
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Abstract
It is as made from the raw material of following parts by weight the invention discloses a kind of Chinese materia medica preparation for treating cataract: 5-7 parts of fructus viticis, 8-10 parts of fructus lycii, 5-7 parts of Equisetum hiemale Linne.The all medicine compatibilities of Chinese materia medica preparation of present invention treatment cataract, it brings out the best in each other, drug effect synergistic effect, have effects that nourishing liver and kidney, cooling blood for improving eyesight, inhibits the ciliary muscle of eyeball to change the influence to eyesight, microcirculation is promoted to adjust, the Chinese materia medica preparation is convenient to take, securely and reliably, it is improved the eyesight level of cataract patient, cataract is made to have the function that treating both manifestation and root cause of disease.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese materia medica preparation for treating cataract.
Background technique
Cataract is one of common eye disease, and being that crystalline lens generation is muddy in eyes becomes opaque by transparent, hinders light
Into intraocular, to affect eyesight.The initial stage muddiness of cataract is little to eyesight influence, can then aggravate gradually, final bright
Aobvious affect vision even is blinded.Eye microcirculation caused by the reason of pathogenesis of cataract mainly liver-yang hyperactivity is unsmooth and crystalline lens
It is external that metabolism protein cannot decompose exclusion completely, cause in eyes crystalline lens that muddiness occurs and become opaque by transparent, hinder light
Line enters intraocularly, to affect eyesight.Initial stage muddiness is little to eyesight influence, when muddiness aggravates, hinders light transmission
Crystal focuses on the photosensitive tissue retina positioned at eyeball inner wall, and the muddy crystalline protein by forming crystal of crystal is denaturalized cohesion
It is caused, hence it is evident that affect vision and even blind.
The cardinal symptom of cataract is the hypopsia and blurred vision of painless no feel, less serious case's hypopsia, severe one eyesight
It may only see manual or light sensation, furthermore can also behave as myopia degree intensification, need often frequently replacement glasses；Monodiplorpia
Or polyopia, stationarity shadow or view object obfuscation, color lose the symptoms such as vividness and photophobia, dazzle at the moment, under normal circumstances
Cataract is without erythralgia symptom.As prevented and treated not in time, eyesight by degradation and blindness, the treatment of cataract not in time and
Malpractice can all cause the high risks to human eye.
Though having new development in recent years to the treatment of cataract, medically most of or high praise operative treatment and drug are protected
Keep two big methods for the treatment of.Operative treatment is the current treatment relatively effective means of cataract, but operative treatment has its adaptability
And limitation has higher requirement to the technical level of the condition of operation, especially doctor in addition to costly.In addition it performs the operation
Treatment can only treat the symptoms and cannot effect a permanent cure, and cannot thoroughly improve eye microcirculation, there are still the possibility for having recurrence.On the other hand, by
It is old and frail advanced age people mostly in cataract patient, and there is some diseases in various degree again, such as heart disease, high blood
Some old synthetic diseases such as pressure, diabetes, retinopathy, these diseases all to operative treatment bring many uncertain risks because
Element, once occur surprisingly, will lead to lifelong blindness.China's traditional Chinese medicine, which is treated, then passes through whole body diagnosis and treatment based on an overall analysis of the illness and the patient's condition, early cataract,
Both liver and kidney deficiency person is given and is tonified the liver and kidney, Qiju Dihuang Wan or Shiyu Yeguang Wan are just selected；Deficiency of the spleen causing weakness of QI person, which gives, to invigorate the spleen and benefit qi, and Fang Xuan is mended
Middle Qi-benefiting decoction；The person of disturbing gives The flat liver of heat-clearing in liver heat, and the shell of seaear is just selected to dissipate；The deficiency of Yin holds damp and hot person under the arm and gives nourishing Yin and clearing heat, wide middle promoting diuresis,
Sweet dew is selected to drink in side.Above-mentioned therapeutic agent can only delay the generation of the state of an illness, development, and effect is still undesirable.Therefore, it is true to develop curative effect
It cuts, safely and efficiently treatment cataract medicine is very necessary.
Summary of the invention
The present invention provides a kind of Chinese materia medica preparations for treating cataract, and the Chinese materia medica preparation is convenient to take, securely and reliably, can
Achieve the purpose that treating both manifestation and root cause of disease.
To achieve the above object, technical solution of the present invention is implemented as follows:
A kind of Chinese materia medica preparation for treating cataract is as made from the raw material of following parts by weight: 5-7 parts of fructus viticis, fructus lycii
8-10 parts, 5-7 parts of Equisetum hiemale Linne.
Preferably, a kind of Chinese materia medica preparation for treating cataract is as made from the raw material of following parts by weight: 6 parts of fructus viticis,
9 parts of fructus lycii, 6 parts of Equisetum hiemale Linne.
The Chinese materia medica preparation that the present invention treats cataract is as made from following methods: powder, fructus viticis are beaten after fructus lycii is dried
Also beat powder with Equisetum hiemale Linne, three be sufficiently mixed uniformly to get.
The present invention treat cataract Chinese materia medica preparation usage and dosage: mixing in water for oral taking, a side be it is one, one is one, one
Day twice, respectively takes primary for 1 hour after morning and evening dinner.10 days are 1 course for the treatment of, and taking the 1-4 course for the treatment of can fully recover.
Points for attention: the marors such as fasting green onion, ginger and garlic during medication.
The principle of each raw material is as follows:
Fructus viticis: cold nature, acrid flavour, hardship.Dispelling wind and heat from the body, head clearing.It has a headache for anemopyretic cold, gingivitis, mesh
Red more tears, mesh is secretly unknown, has a dizzy spell.
Fructus lycii: it is mild-natured, it is sweet in flavor.Nourishing the liver, nourshing kidney, moistening lung.For caused by liver and kidney deficiency, have a dizzy spell, visually unclear, waist and knee acid
Soft, cough due to consumptive disease quenches one's thirst and draws drink.
Equisetum hiemale Linne: it is sweet in flavor, bitter, it is mild-natured.It clears liver and improve vision, stops blooding, inducing diuresis for treating strangurtia.Main anemopyretic cold, cough, red eye, swell pain,
Cloudiness, nosebleed epistaxis, hematuria, discharging fresh blood stool, stranguria, jaundice, leukorrhagia, fracture.
In the present invention, fructus viticis is monarch, wind-dispelling heat-dissipating, cooling blood for improving eyesight, increase ocular circulation, clearind deficient heat；Fructus lycii is
The effect of minister tonifies the liver and kidney, supplementing qi and nourishing yin, supports eyes, and principal drug assistance reinforces wind-dispelling heat-dissipating improving eyesight, helps source of generating QI and blood；Wood
Crafty grass is assistant, is clear liver and improved vision, cooling blood and hemostasis.
Beneficial effects of the present invention: the present invention treats all medicine compatibilities of Chinese materia medica preparation of cataract, brings out the best in each other, drug effect collaboration
Effect, has effects that nourishing liver and kidney, cooling blood for improving eyesight, inhibits the ciliary muscle of eyeball to change the influence to eyesight, promotes capilary
Circulation is adjusted, and the Chinese materia medica preparation is convenient to take, securely and reliably, is improved the eyesight level of cataract patient, makes cataract
Have the function that treating both manifestation and root cause of disease.
Specific embodiment
The present invention is described below with reference to specific embodiments.It will be appreciated by those skilled in the art that these embodiments are only
For illustrating the present invention, do not limit the scope of the invention in any way.
Embodiment 1
A kind of Chinese materia medica preparation for treating cataract is as made from the raw material of following parts by weight: 5 parts of fructus viticis, fructus lycii 8
Part, 7 parts of Equisetum hiemale Linne.
The Chinese materia medica preparation of the treatment cataract is as made from following methods: powder, fructus viticis and wood are broken after fructus lycii is dried
Crafty grass also beats powder, three be sufficiently mixed uniformly to get.
Usage and dosage: mixing in water for oral taking, a side be it is one, one is one, twice a day, respectively takes one within 1 hour after morning and evening dinner
It is secondary.
Embodiment 2
A kind of Chinese materia medica preparation for treating cataract is as made from the raw material of following parts by weight: 6 parts of fructus viticis, fructus lycii 9
Part, 6 parts of Equisetum hiemale Linne.
The Chinese materia medica preparation of the treatment cataract is as made from following methods: powder, fructus viticis and wood are broken after fructus lycii is dried
Crafty grass also beats powder, three be sufficiently mixed uniformly to get.
Usage and dosage: mixing in water for oral taking, a side be it is one, one is one, twice a day, respectively takes one within 1 hour after morning and evening dinner
It is secondary.
Embodiment 3
A kind of Chinese materia medica preparation for treating cataract is as made from the raw material of following parts by weight: 7 parts of fructus viticis, fructus lycii 10
Part, 5 parts of Equisetum hiemale Linne.
The Chinese materia medica preparation of the treatment cataract is as made from following methods: powder, fructus viticis and wood are broken after fructus lycii is dried
Crafty grass also beats powder, three be sufficiently mixed uniformly to get.
Usage and dosage: mixing in water for oral taking, a side be it is one, one is one, twice a day, respectively takes one within 1 hour after morning and evening dinner
It is secondary.
Comparative example 1
A kind of Chinese materia medica preparation for treating cataract is as made from the raw material of following parts by weight: 9 parts of fructus lycii, Equisetum hiemale Linne 6
Part.
The Chinese materia medica preparation of the treatment cataract is as made from following methods: powder is beaten after fructus lycii is dried, Equisetum hiemale Linne beats powder,
The two be sufficiently mixed uniformly to get.
Comparative example 2
A kind of Chinese materia medica preparation for treating cataract is as made from the raw material of following parts by weight: 6 parts of fructus viticis, Equisetum hiemale Linne 6
Part.
The Chinese materia medica preparation of the treatment cataract is as made from following methods: fructus viticis and Equisetum hiemale Linne being beaten powder, the two is filled
Point be uniformly mixed to get.
Comparative example 3
A kind of Chinese materia medica preparation for treating cataract is as made from the raw material of following parts by weight: 6 parts of fructus viticis, fructus lycii 9
Part.
The Chinese materia medica preparation of the treatment cataract is as made from following methods: powder is beaten after fructus lycii is dried, fructus viticis beats powder,
The two be sufficiently mixed uniformly to get.
Rabbit eyes Bulbar conjunctiva microcirculation is tested
Rabbit 64, half male and half female, weight 1.8-2.2kg, random point 8 groups, every group 8.Blank control group stomach-filling is androgynous
Long-pending physiological saline；Administration group gastric infusion block removing then extra large Pu's piece 0.3g/kg；Experimental group 1-3 distinguishes gastric infusion embodiment 1-3
Treat the Chinese materia medica preparation of cataract, 0.2g/kg；Control group 1-3 distinguishes the Chinese medicine system of gastric infusion comparative example 1-3 treatment cataract
Agent, 0.2g/kg.Successive administration 3d, 1 time a day, in 1h after the last administration, rabbit ear vein injects 10% fluorescein sodium physiological saline
There is the time of fluorescence in solution 100mg/kg, record rabbit eye conjunctiva.Experimental result is shown in Table 1.
1 pair of family of table exempts from eye conjunctiva microcirculation experimental result
Compared with blank control group: * * P < 0.01；With administration group ratio: #P < 0.05.
As shown in Table 1, administration group, experimental group 1-3 and control group 1-3 have acceleration to rabbit conjunctival microcirculation, and real
It is stronger compared with the microcirculation that administration group and control group 1-3 improve eye conjunctiva to test group 1-3.
Rat galactolipin cataract model is tested
SD system big white mouse, makees eye examination first, selects the normal person of eyes 80, half male and half female, 60~80g of weight divides 8 at random
Group, every group 10.The physiological saline of blank control group stomach-filling same volume；Administration group gastric infusion 0.6g/kg；Experimental group 1-3 points
The Chinese materia medica preparation of other gastric infusion embodiment 1-3 treatment cataract, 0.5g/kg, successive administration 3d, once a day, each group after 3d
It (is mixed in feed, feed and each half of galactolipin) to D- galactolipin, while continuing gastric infusion and physiological saline, every 3d is used
Eye examination with slitlamp microscope Cataractogenesis process, eyes drip mydriatic before checking.Control group 1-3 distinguishes gastric infusion comparison
The Chinese materia medica preparation of example 1-3 treatment cataract, 0.6g/kg, successive administration 3d, once a day, each group gives D- galactolipin (mixed after 3d
In feed, feed and each half of galactolipin), while continuing gastric infusion and physiological saline, every 3d eye slit-lamp microscope
Check Cataractogenesis process, eyes drip mydriatic before checking.Model control group cataract maturing rate up to 80% or more, stop to
Medicine and galactolipin carry out statistical procedures using core muddiness and the time for forming cataract as index to check the effect of drug.
Experimental result is shown in Table 2.
Table 2 is to rat galactolipin from cataract or glaucoma model experiment results
Compared with blank control group: * * P < 0.01；With administration group ratio: #P < 0.05.
As shown in Table 2, administration group, experimental group 1-3 and control group 1-3, which have rat galactolipin cataract model, slows down core
Muddy and the Cataractogenesis time effect, has significant difference compared with blank control group.Experimental group 1-3 compared with administration group and
Control group 1-3 is strong to the formation inhibiting effect of rat galactolipin cataract.
Clinical data
General information: clinical observation cataract patient 80,2 groups are randomly divided into.Wherein, treatment group 40, wherein male 21
Example, female 19, the age 50-65 years old, average age 60.5 ± 4.8 years old, course of disease 1.7-7.0: control group 40, wherein male 20
Example, female 20, the age 50-66 years old, average age 60.1 ± 5.0 years old, course of disease 1.8-7.2.Two groups of patients gender, the age,
The general information comparing difference such as the course of disease, state of an illness is not statistically significant (P > 0.05), is comparable.
Diagnosis and CM syndrome differentiation criterion and foundation: with reference to " Chinese medicine encyclopedia: ophthalmology of traditional Chinese medicine " " the dialectical rule of Syndrome in TCM marquis
Model " (People's Health Publisher, 91 years first editions).Chinese combination of Chinese tradiational and Western medicine asthenic symptoms and disease of old people research committee work out " in
Cure the dialectical reference standard of asthenic symptoms " combine ophthalmology researcher clinical experience to work out.Primary symptom: 1. blurred vision, 2. brilliant pearl is muddy.It is secondary
Disease: 1. eye is fine dry and astringent, 2. dry throat, 3. insomnia forgetfulness, and 4. cold sweat is passed out semen, 5. soreness and weakness of waist and knees, 6. tinnitus such as cicada, and 7. tongue is red few
Tongue fur or without tongue fur, 8. thready rapid pulse.It is all to have primary symptom binomial, add minor symptom binomial, can dialectical be cataract.
Be included in standard: (1) age, 80 years old hereinafter, without ocular complications and other eye disease to affect vision at 45 years old or more；
(2) eyesight is 4.0 or more；(3) cataract of old people category initial phase, immature phase person；(4) whole body is without other serious diseases, energy
The person that adheres to medication treatment.
Exclusion criteria: (1) cataract of old people belongs to maturity period, overripe stage person.(2) traumatic, diabetes, it is congenital it is white in
Barrier, complicated cataract merge other influences eyesight eye patient.(3) whole body has other serious diseases, cannot adhere to that medication is controlled
Treatment person.(4) ametropic patient.
Treatment method: control group administration Shiyu Yeguang Wan (Guangzhou Chenliji Pharmaceutical Factory's production, lot number: 921201), and water-honeyed pill,
Each taking 6 grams, take daily 2 times, boiled water is swallowed.Treatment group take the present invention treatment cataract Chinese materia medica preparation, mixing in water for oral taking,
One side be it is one, one is one, twice a day, respectively takes within 1 hour after morning and evening dinner primary.10 days are 1 course for the treatment of, share 3 treatments of medicine
Journey.
The marors such as fasting green onion, ginger and garlic during treatment.
Curative effect determinate standard: with reference to dialectical " the Chinese medicine void for grinding committee's formulation with disease of old people of Chinese combination of Chinese tradiational and Western medicine asthenic symptoms
Demonstrate,prove dialectical reference standard ", " Chinese medicine encyclopedia ophthalmology of traditional Chinese medicine " formulate curative effect judging standard:
Effective: eyesight mentions four rows or more after treatment, and lens opacity situation is stable or turbidity mitigates, symptom product after treatment
Score value decline >=2/3；
Effective: eyesight mentions two rows or more after treatment, and before lens opacity degree is with treatment, symptom integral value declines < 2/3 simultaneously
≥1/3；
Invalid: eyesight is deepened without progress or decline, lens opacity degree after treatment, and symptom integral value declines < 1/ after treatment
3。
Total effective rate=[(effective+effectively)/total number of cases] × 100%.
Treatment results: the treatment results for the treatment of group and control group are shown in Table 3.
3 two groups of clinical treatment outcomes (%) of table
As shown in Table 3, effective 4 for the treatment of group, effective 27, no effect 9, total effective rate 77.5%；Control group effective 2
Example, effective 16, invalid 12, total effective rate 45.0%.2 groups of cure rates and total effective rate comparing difference are statistically significant
(P < 0.05), treatment group's curative effect are better than control group.
In treatment clinical course, the vital sign (blood pressure, heart rate, body temperature, breathing) of patient, physical examination, blood biochemical
Analysis, electrocardiogram and the routine urinalysis Non Apparent Abnormality during treatment.
Typical case
Case 1: Zou, male, 52 years old.Patient often has a headache because operating pressure is big, and the decline of two eye visions sees that thing is fuzzy,
It is checked through hospital and is diagnosed as acute cataract；After taking 1 course for the treatment of of Chinese materia medica preparation of the present invention, see that the symptoms such as thing is fuzzy disappear substantially
It loses, continues after taking 2 course for the treatment of, symptom completely disappears, and vision restoration is normal, and follow-up is so far without recurrence.
Case 3: it is rich certain, female, 64 years old.Patient's eyes suffered from cataract more than 3 years, and eyesight only has 0.3-0.4, due to heart
It is bad, it is not easy operative treatment, and look anxiety, it can only medication treatment；Take Chinese materia medica preparation 2 treatments of present invention treatment cataract
Cheng Hou, malaise symptoms totally disappeared mistake, continue after taking 2 course for the treatment of, and anxiety symptom disappears, and vision restoration is normal, and follow-up is so far without multiple
Hair.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details.
Claims (2)
1. a kind of Chinese materia medica preparation for treating cataract, which is characterized in that be as made from the raw material of following parts by weight: fructus viticis 5-
7 parts, 8-10 parts of fructus lycii, 5-7 parts of Equisetum hiemale Linne.
2. treating the Chinese materia medica preparation of cataract according to claim 1, which is characterized in that be by the raw material system of following parts by weight
: 6 parts of fructus viticis, 9 parts of fructus lycii, 6 parts of Equisetum hiemale Linne.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101361892A (en) * | 2008-10-09 | 2009-02-11 | 陕西东泰制药有限公司 | Traditional Chinese medicine formulation for treating cataract and preparation method thereof |
| CN103860736A (en) * | 2014-04-05 | 2014-06-18 | 赵凤娥 | Chinese herba preparation for treating cataract and preparation method thereof |
| CN104095991A (en) * | 2014-06-30 | 2014-10-15 | 赵德桂 | Traditional Chinese medicine eye-protection tea |
-
2019
- 2019-04-14 CN CN201910311542.3A patent/CN109954051A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101361892A (en) * | 2008-10-09 | 2009-02-11 | 陕西东泰制药有限公司 | Traditional Chinese medicine formulation for treating cataract and preparation method thereof |
| CN103860736A (en) * | 2014-04-05 | 2014-06-18 | 赵凤娥 | Chinese herba preparation for treating cataract and preparation method thereof |
| CN104095991A (en) * | 2014-06-30 | 2014-10-15 | 赵德桂 | Traditional Chinese medicine eye-protection tea |
Non-Patent Citations (1)
| Title |
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| 谢文英: "《名医珍藏百病食疗》", 31 May 2014, 陕西科学技术出版社 * |
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