CN109939018B - Natural soothing and moisturizing composition containing ceramide and preparation method thereof - Google Patents
Natural soothing and moisturizing composition containing ceramide and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a natural soothing and moisturizing composition containing ceramide and a preparation method thereof, wherein the natural soothing and moisturizing composition is prepared from ceramide, an neem tree extract, a lithospermum extract, polyethylene glycol-400, 1, 3-butanediol, polyoxyethylene (20) sorbitan monolaurate, ethanol, apricot gum, hydroxybenzoate and deionized water. The natural soothing and moisturizing composition has excellent skin moisturizing, soothing and anti-inflammatory effects, and thus can be used for daily care of various skin types, particularly dry skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, and in particular relates to a natural soothing and moisturizing composition containing ceramide and a preparation method thereof.
Background
In recent years, with the development of economy and the improvement of living standard, people have more and more pursuit for having healthy and beautiful skin. Due to the influence of a series of external negative factors such as air pollution, wind and sun exposure, dry weather and the like, the skin barrier of people is easy to be damaged, and the problems of skin water shortage, dryness, roughness, peeling, red swelling, chapping and the like occur, so that the skin aging is accelerated. These skin problems are unacceptable to a large number of beauty lovers.
At present, a plurality of products such as emulsion, cream, essence and the like aiming at solving the problem of skin water shortage are sold in the market. However, these products have single function and limited effect, and cannot meet the requirements of people. How to find safe and effective means for moisturizing, moisturizing and relieving the skin becomes a problem which is increasingly solved by people.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a natural soothing and moisturizing composition and a preparation method thereof.
The natural soothing and moisturizing composition is prepared from ceramide, an Azadirachta indica (Azadirachta indica) extract, a lithospermum (Radix Arnebiae) extract, polyethylene glycol-400, 1, 3-butanediol, polyoxyethylene (20) sorbitan monolaurate, ethanol, apricot gum, hydroxybenzoate and deionized water.
Specifically, the invention provides a natural soothing and moisturizing composition which is characterized by being prepared from the following raw materials in parts by weight: 6-10 parts of ceramide and 1-4 parts of neem tree extract; 1-4 parts of lithospermum extract; 5-9 parts of polyethylene glycol-400; 5-9 parts of 1, 3-butanediol; 1-5 parts of polyoxyethylene (20) sorbitan monolaurate; 13-17 parts of ethanol; 1-5 parts of apricot gum; 0.4-0.8 part of hydroxybenzoate; and 60-80 parts of deionized water.
In a preferred embodiment, the natural soothing moisturizing composition is prepared from the following raw materials in parts by weight: 7-9 parts of ceramide and 2-3 parts of neem tree extract; 2-3 parts of lithospermum extract; 6-8 parts of polyethylene glycol-400; 6-8 parts of 1, 3-butanediol; 2-4 parts of polyoxyethylene (20) sorbitan monolaurate; 14-16 parts of ethanol; 2-4 parts of apricot gum; 0.5-0.7 part of hydroxybenzoate; and 65-75 parts of deionized water.
In a more preferred embodiment, the natural soothing moisturizing composition is prepared from the following raw materials in parts by weight: 8 parts of ceramide and 2.5 parts of neem tree extract; 2.5 parts of lithospermum extract; polyethylene glycol-4007 parts; 7 parts of 1, 3-butanediol; 3 parts of polyoxyethylene (20) sorbitan monolaurate; 15 parts of ethanol; 3 parts of apricot gum; 0.6 part of hydroxybenzoate; and 70 parts of deionized water.
Preferably, the natural soothing moisturizing composition is in the form of a lotion. The cosmetic lotion is also called as astringent lotion, and is a liquid cosmetic in the form of transparent, semitransparent or opaque emulsion. Lotions are often used for moisturizing, soothing applications after cleansing the skin.
In one embodiment, the present invention also provides a process for preparing a natural soothing moisturizing composition of the present invention, the process comprising the steps of: 1) mixing neem tree extract, radix Arnebiae extract, polyoxyethylene (20) sorbitan monolaurate, gum apricot, and hydroxybenzoate with ethanol at room temperature, and stirring; 2) mixing ceramide, polyethylene glycol-400, 1, 3-butanediol and deionized water at room temperature, and uniformly stirring; 3) adding the mixture prepared in the step 1) into the mixture prepared in the step 2), and placing the mixture in an ultrasonic generator to mix for 5-10min at room temperature under high-frequency oscillation of 30-50Hz to obtain the natural soothing and moisturizing composition.
Ceramide (Ceramide), i.e., N-fatty acyl sphingosine, is a compound in which one molecule of sphingoid is bonded to one molecule of fatty acid through an amide bond. Ceramides are a major part of intercellular matrix, and play an important role in maintaining the water balance of the stratum corneum and playing a barrier role. In the outermost stratum corneum of the skin, approximately 40% to 50% of sebum is made up of ceramide. The types of ceramides are many, such as ceramide 1, ceramide 3, ceramide 6-II, and the like. A mixture of ceramide 1 and ceramide 3 in a weight ratio of 1: 3 is preferably used in the present invention.
Azadirachta is a plant of the Azadirachta family native to tropical and subtropical countries of Asia, such as India, Bangladesh, Srilanca. Neem tree is known to contain a specific substance, azadirachtin (kumujian), which has a broad spectrum of highly effective insecticidal efficacy, and is used to control a variety of insects and nematodes.
Preferably, the neem tree extract is prepared by the following method: taking mixture of dried bark, leaves and seeds of Azadirachta indica at weight ratio of 1: 2, pulverizing, adding 50 v/v% ethanol at ratio of 1g mixture to 10ml 50 v/v% ethanol, soaking at room temperature for 2-4 days, and rotary steaming at 40 deg.C water bath temperature to dry to obtain Azadirachta indica extract.
The radix Arnebiae is dried root of arnebia euchroma (Royle) Johnst, Lithospermum erythrorhizon Sieb.et Zucc, or Lithospermum erythrorhizon Bunge of Boraginaceae. It is thought that Zi Cao has the functions of cooling blood, promoting blood circulation, removing toxicity and promoting eruption, so it is indicated for eczema, erysipelas, carbuncle and ulcer.
Preferably, the lithospermum extract is prepared by the following method: pulverizing dry radix Arnebiae, adding n-hexane into 1g of the mixture corresponding to 8ml of n-hexane, soaking at room temperature for 6-8 days, and rotary steaming at 40 deg.C in water bath to dry to obtain radix Arnebiae extract.
The inventors of the present application have unexpectedly found that the natural soothing and moisturizing composition prepared by the method of the present invention has excellent skin moisturizing and moisturizing effects, and also has skin soothing effect, and can inhibit inflammatory reactions such as telangiectasia, pigmentation or burning pain, and thus can be used for the care of various skin types, particularly dry skin.
Detailed Description
In order to further understand the spirit and gist of the present invention, those skilled in the art will now describe preferred embodiments of the present invention and effects thereof with reference to specific examples and experimental examples. It is to be understood, however, that the description is intended only to further illustrate features and advantages of the present invention, and not to limit in any way the claims of the present invention.
Example 1
Preparation of neem tree extract
Collecting 50g mixture of dried bark, leaves and seeds of Azadirachta indica A.W. in weight ratio of 1: 2, pulverizing, adding 500mL 50 v/v% ethanol, soaking at room temperature for 3 days, and rotary steaming at 40 deg.C in water bath to dry to obtain Azadirachta indica A.W. extract.
Example 2
Preparation of Lithospermum erythrorhizon extract
Taking 50g of dry roots of lithospermum, crushing, adding 400mL of normal hexane, soaking for 7 days at room temperature, and then carrying out rotary evaporation at the water bath temperature of 40 ℃ until the dry roots are dry to obtain the lithospermum extract.
Example 3
Toning lotion 1
Weighing 6g of a mixture of ceramide 1 and ceramide 3 at a weight ratio of 1: 3, 1g of neem tree extract (prepared according to example 1), 1g of lithospermum extract (prepared according to example 2), 5g of polyethylene glycol-4005 g, 5g of 1, 3-butanediol, 1g of polyoxyethylene (20) sorbitan monolaurate, 13g of ethanol, 1g of apricot gum, 0.4g of hydroxybenzoate and 60g of deionized water, and preparing according to the following method: 1) mixing neem tree extract, radix Arnebiae extract, polyoxyethylene (20) sorbitan monolaurate, gum apricot, and hydroxybenzoate with ethanol at room temperature, and stirring; 2) mixing a mixture of ceramide 1 and ceramide 3 in a weight ratio of 1: 3, polyethylene glycol-400, 1, 3-butanediol and deionized water at room temperature, and uniformly stirring; 3) adding the mixture prepared in the step 1) into the mixture prepared in the step 2), and placing the mixture in an ultrasonic generator to mix for 8min at room temperature under high-frequency oscillation of 40Hz to obtain the natural soothing and moisturizing composition (toning lotion 1).
Example 4
Toning lotion 2
8g of a mixture of ceramide 1 and ceramide 3 at a weight ratio of 1: 3, 2.5g of neem tree extract (prepared according to example 1), 2.5g of lithospermum extract (prepared according to example 2), 7g of polyethylene glycol-4007 g, 7g of 1, 3-butanediol, 3g of polyoxyethylene (20) sorbitan monolaurate, 15g of ethanol, 3g of apricot tree gum, 0.6g of hydroxybenzoate and 70g of deionized water were weighed and prepared according to the following method: 1) mixing neem tree extract, radix Arnebiae extract, polyoxyethylene (20) sorbitan monolaurate, gum apricot, and hydroxybenzoate with ethanol at room temperature, and stirring; 2) mixing a mixture of ceramide 1 and ceramide 3 in a weight ratio of 1: 3, polyethylene glycol-400, 1, 3-butanediol and deionized water at room temperature, and uniformly stirring; 3) adding the mixture prepared in the step 1) into the mixture prepared in the step 2), and placing the mixture in an ultrasonic generator to mix for 8min at room temperature under high-frequency oscillation of 40Hz to obtain the natural soothing and moisturizing composition (toning lotion 2).
Example 5
Toning lotion 3
Weighing 10g of a mixture of ceramide 1 and ceramide 3 at a weight ratio of 1: 3, 4g of neem tree extract (prepared according to example 1), 4g of lithospermum extract (prepared according to example 2), 9g of polyethylene glycol-4009 g, 9g of 1, 3-butanediol, 5g of polyoxyethylene (20) sorbitan monolaurate, 17g of ethanol, 5g of apricot tree gum, 0.8g of hydroxybenzoate and 80g of deionized water, and preparing according to the following method: 1) mixing neem tree extract, radix Arnebiae extract, polyoxyethylene (20) sorbitan monolaurate, gum apricot, and hydroxybenzoate with ethanol at room temperature, and stirring; 2) mixing a mixture of ceramide 1 and ceramide 3 in a weight ratio of 1: 3, polyethylene glycol-400, 1, 3-butanediol and deionized water at room temperature, and uniformly stirring; 3) adding the mixture prepared in the step 1) into the mixture prepared in the step 2), and placing the mixture in an ultrasonic generator to mix for 8min at room temperature under high-frequency oscillation of 40Hz to obtain the natural soothing and moisturizing composition (toning lotion 3).
Comparative example 1
Toning lotion 4
Weighing 8g of a mixture of ceramide 1 and ceramide 3 in a weight ratio of 1: 3, 7g of polyethylene glycol-4007 g, 7g of 1, 3-butanediol, 3g of polyoxyethylene (20) sorbitan monolaurate, 15g of ethanol, 3g of apricot tree gum, 0.6g of hydroxybenzoate and 70g of deionized water, and preparing according to the following method: 1) mixing polyoxyethylene (20) sorbitan monolaurate, apricot gum, hydroxybenzoate and ethanol at room temperature, and stirring; 2) mixing a mixture of ceramide 1 and ceramide 3 in a weight ratio of 1: 3, polyethylene glycol-400, 1, 3-butanediol and deionized water at room temperature, and uniformly stirring; 3) adding the mixture prepared in the step 1) into the mixture prepared in the step 2), and placing the mixture in an ultrasonic generator to mix for 8min at room temperature under high-frequency oscillation of 40Hz to obtain the natural soothing and moisturizing composition (toning lotion 4).
Comparative example 2
Toning lotion 5
8g of a mixture of ceramide 1 and ceramide 3 at a weight ratio of 1: 3, 2.5g of neem tree extract (prepared according to example 1), 7g of polyethylene glycol-4007 g, 7g of 1, 3-butylene glycol, 3g of polyoxyethylene (20) sorbitan monolaurate, 15g of ethanol, 3g of apricot tree gum, 0.6g of hydroxybenzoate and 70g of deionized water were weighed out and prepared as follows: 1) mixing neem tree extract, polyoxyethylene (20) sorbitan monolaurate, apricot gum, hydroxybenzoate with ethanol at room temperature, and stirring; 2) mixing a mixture of ceramide 1 and ceramide 3 in a weight ratio of 1: 3, polyethylene glycol-400, 1, 3-butanediol and deionized water at room temperature, and uniformly stirring; 3) adding the mixture prepared in the step 1) into the mixture prepared in the step 2), and placing the mixture in an ultrasonic generator to mix for 8min at room temperature under high-frequency oscillation of 40Hz to obtain the natural soothing and moisturizing composition (toning lotion 5).
Comparative example 3
Toning lotion 6
8g of a mixture of ceramide 1 and ceramide 3 at a weight ratio of 1: 3, 2.5g of lithospermum extract (prepared according to example 2), 7g of polyethylene glycol-4007 g, 7g of 1, 3-butanediol, 3g of polyoxyethylene (20) sorbitan monolaurate, 15g of ethanol, 3g of apricot tree gum, 0.6g of hydroxybenzoate and 70g of deionized water were weighed and prepared according to the following method: 1) mixing radix Arnebiae extract, polyoxyethylene (20) sorbitan monolaurate, gum Pruni, and hydroxybenzoate with ethanol at room temperature, and stirring; 2) mixing ceramide 1 and ceramide 3 at a weight ratio of 1: 3, polyethylene glycol-400, 1, 3-butanediol and deionized water, and stirring uniformly; 3) adding the mixture prepared in the step 1) into the mixture prepared in the step 2), and placing the mixture in an ultrasonic generator to mix for 8min at room temperature under high-frequency oscillation of 40Hz to obtain the natural soothing and moisturizing composition (toning lotion 6).
Examples of the experiments
The purpose of this experimental example was to investigate whether the natural soothing moisturizing composition (lotion) prepared according to the example of the present invention has moisturizing, soothing effects.
1. Investigation mode
A total of 84 subjects identified as having a "dry skin condition" were recruited to the experiment, with an age between 38 and 45 years, of which 39 were male and 45 were female. The clinical manifestations of the subject of the "dry skin condition" are a condition of the facial skin with lack of water, dryness, the appearance of dandruff, fine lines or chaps, and the skin being accompanied by at least one of the inflammatory reactions of telangiectasia, pigmentation or burning pain.
The subjects were asked to refrain from using any skin care product for a week prior to conducting the experiment, in addition to daily skin cleansing.
2. Application method
The subjects were randomized into 7 groups of 12 people each. Groups 1, 2 and 3 are experimental groups, to which the natural soothing and moisturizing compositions (lotions 1, 2 and 3) prepared according to examples 3, 4 and 5 of the present invention were applied, respectively. Groups 4, 5 and 6 are experimental control groups to which the natural soothing and moisturizing compositions (lotions 4, 5 and 6) prepared according to comparative examples 1, 2 and 3 of the present invention were applied, respectively. Group 7 was a blank control group, without any skin care product applied.
The specific application method comprises the following steps: after cleansing the skin every morning and evening, the natural soothing moisturizing composition (lotion) prepared according to the present invention was dipped in a cotton pad, applied to the forehead and cheeks, and gently tapped to promote its absorption into the skin. Application was continued for 4 weeks.
3. Evaluation method
The change in skin moisture content of each group of subjects before the start of the experiment and 4 weeks after application of the natural soothing moisturizing composition (lotion) of the present invention was measured using a commercially available skin moisture meter.
Meanwhile, after the experiment was finished, each subject was asked to score the effect of the applied natural soothing and moisturizing composition (lotion) in soothing the skin in the range of 0 to 5 points according to the description of the following table.
The score values for each experimental group were then summed and divided by the total number of subjects to obtain the average score for each group.
4. Results of the experiment
Table 1 skin moisture test results
| Group of | Water content before use% | Water content after application% |
| Toning lotion 1 group | 36.9±3.3 | 58.3±5.4 |
| Toning lotion 2 groups | 34.6±2.7 | 59.2±6.2 |
| Toning lotion 3 groups | 35.3±3.1 | 58.7±6.1 |
| Toning lotion 4 groups | 36.2±3.0 | 43.8±4.6 |
| Toning lotion 5 groups | 37.1±4.1 | 49.7±5.2 |
| Toning lotion 6 groups | 35.2±3.6 | 48.8±4.9 |
| Blank control group | 35.5±3.8 | 35.7±3.7 |
(n-12, results expressed as mean soil standard deviation)
TABLE 2 skin soothing effect Scoring test results
| Group of | Skin soothing effect score |
| Toning lotion 1 group | 4.6±0.3 |
| Toning lotion 2 groups | 4.7±0.2 |
| Toning lotion 3 groups | 4.6±0.2 |
| Toning lotion 4 groups | 3.2±0.2 |
| Toning lotion 5 groups | 3.9±0.3 |
| Toning lotion 6 groups | 3.7±0.2 |
| Blank control group | 0.3±0.1 |
(n-12, results expressed as mean soil standard deviation)
5. Discussion of the related Art
The above results indicate that the lotion containing a certain amount of ceramide alone as an active ingredient has certain moisturizing and soothing effects on the skin compared to the blank control group. The inventors have unexpectedly found that, when a certain amount of neem tree extract or lithospermum erythrorhizon extract as an active ingredient is added to a cosmetic water composition, it has an effect of improving the moisturizing and soothing effects of the skin. When a certain amount of three active ingredients, namely ceramide, the neem tree extract and the lithospermum extract, are used in a matching way, the skin moisturizing and soothing effects are obviously enhanced. This demonstrates that the natural soothing and moisturizing composition of the present invention has excellent skin moisturizing, soothing and anti-inflammatory effects and thus can be used for daily care of various skin types, especially dry skin.
The foregoing is only a preferred embodiment of the present invention. It should be noted that, for those skilled in the art, without departing from the spirit and principle of the present invention, several improvements, modifications, equivalents and the like can be made, and these improvements, modifications, equivalents and the like also should be regarded as falling within the protection scope of the present invention.
Claims (8)
1. A natural soothing and moisturizing composition is characterized by being prepared from the following raw materials in parts by weight: 6-10 parts of ceramide and 1-4 parts of neem tree extract; 1-4 parts of lithospermum extract; 5-9 parts of polyethylene glycol-400; 5-9 parts of 1, 3-butanediol; 1-5 parts of polyoxyethylene (20) sorbitan monolaurate; 13-17 parts of ethanol; 1-5 parts of apricot gum; 0.4-0.8 part of hydroxybenzoate; 60-80 parts of deionized water;
the neem tree extract is prepared by the following method: taking a mixture of dried bark, leaves and seeds of the neem tree in a weight ratio of 1: 2, crushing, adding 50 v/v% ethanol into 1g of the mixture according to a proportion of 10mL of 50 v/v% ethanol, soaking at room temperature for 2-4 days, and then carrying out rotary evaporation at a water bath temperature of 40 ℃ until the mixture is dried to obtain neem extract;
the lithospermum extract is prepared by the following method: taking dry roots of lithospermum erythrorhizon, crushing, adding n-hexane according to the proportion that 1g of mixture corresponds to 8mL of n-hexane, soaking at room temperature for 6-8 days, and then carrying out rotary evaporation at the water bath temperature of 40 ℃ until the materials are dry to obtain the lithospermum erythrorhizon extract.
2. The natural soothing and moisturizing composition according to claim 1, which is prepared from the following raw materials in parts by weight: 7-9 parts of ceramide and 2-3 parts of neem tree extract; 2-3 parts of lithospermum extract; 6-8 parts of polyethylene glycol-400; 6-8 parts of 1, 3-butanediol; 2-4 parts of polyoxyethylene (20) sorbitan monolaurate; 14-16 parts of ethanol; 2-4 parts of apricot gum; 0.5-0.7 part of hydroxybenzoate; and 65-75 parts of deionized water.
3. The natural soothing and moisturizing composition according to claim 2, which is prepared from the following raw materials in parts by weight: 8 parts of ceramide and 2.5 parts of neem tree extract; 2.5 parts of lithospermum extract; polyethylene glycol-4007 parts; 7 parts of 1, 3-butanediol; 3 parts of polyoxyethylene (20) sorbitan monolaurate; 15 parts of ethanol; 3 parts of apricot gum; 0.6 part of hydroxybenzoate; and 70 parts of deionized water.
4. A natural soothing moisturizing composition according to any one of claims 1 to 3 in the form of a lotion.
5. A natural soothing moisturizing composition according to any of claims 1 to 3, wherein the ceramide is a 1: 3 mixture of ceramide 1 and ceramide 3 by weight.
6. A natural soothing moisturizing composition according to any of claims 1 to 3, wherein the neem tree extract is prepared using the following method: taking mixture of dried bark, leaves and seeds of Azadirachta indica at weight ratio of 1: 2, pulverizing, adding 50 v/v% ethanol at ratio of 1g mixture to 10mL 50 v/v% ethanol, soaking at room temperature for 2-4 days, and rotary steaming at 40 deg.C water bath temperature to dry to obtain Azadirachta indica extract.
7. A natural soothing and moisturizing composition according to any one of claims 1 to 3, wherein the comfrey extract is prepared using the following method: taking dry roots of lithospermum erythrorhizon, crushing, adding n-hexane according to the proportion that 1g of mixture corresponds to 8mL of n-hexane, soaking at room temperature for 6-8 days, and then carrying out rotary evaporation at the water bath temperature of 40 ℃ until the materials are dry to obtain the lithospermum erythrorhizon extract.
8. A process for preparing a natural soothing moisturizing composition according to any one of claims 1-7, the process comprising the steps of: 1) mixing neem tree extract, radix Arnebiae extract, polyoxyethylene (20) sorbitan monolaurate, gum apricot, and hydroxybenzoate with ethanol at room temperature, and stirring; 2) mixing ceramide, polyethylene glycol-400, 1, 3-butanediol and deionized water at room temperature, and uniformly stirring; 3) adding the mixture prepared in the step 1) into the mixture prepared in the step 2), and placing the mixture in an ultrasonic generator to mix for 5-10min at room temperature under high-frequency oscillation of 30-50Hz to obtain the natural soothing and moisturizing composition.
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