CN109937257B - 生产目标物质的方法 - Google Patents

生产目标物质的方法 Download PDF

Info

Publication number
CN109937257B
CN109937257B CN201780066708.9A CN201780066708A CN109937257B CN 109937257 B CN109937257 B CN 109937257B CN 201780066708 A CN201780066708 A CN 201780066708A CN 109937257 B CN109937257 B CN 109937257B
Authority
CN
China
Prior art keywords
gene
protein
strain
target substance
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780066708.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN109937257A (zh
Inventor
B.米吉茨
C.罗切
P.凯利
朝里彩香
福井启太
户矢崎未来
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of CN109937257A publication Critical patent/CN109937257A/zh
Application granted granted Critical
Publication of CN109937257B publication Critical patent/CN109937257B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/204—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/20—Synthetic spices, flavouring agents or condiments
    • A23L27/24—Synthetic spices, flavouring agents or condiments prepared by fermentation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y303/00—Hydrolases acting on ether bonds (3.3)
    • C12Y303/01—Thioether and trialkylsulfonium hydrolases (3.3.1)
    • C12Y303/01001—Adenosylhomocysteinase (3.3.1.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201780066708.9A 2016-10-26 2017-10-26 生产目标物质的方法 Active CN109937257B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662413056P 2016-10-26 2016-10-26
US62/413,056 2016-10-26
PCT/JP2017/038796 WO2018079684A1 (en) 2016-10-26 2017-10-26 Method for producing objective substance

Publications (2)

Publication Number Publication Date
CN109937257A CN109937257A (zh) 2019-06-25
CN109937257B true CN109937257B (zh) 2023-06-30

Family

ID=60570163

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780066708.9A Active CN109937257B (zh) 2016-10-26 2017-10-26 生产目标物质的方法

Country Status (5)

Country Link
US (1) US11053519B2 (https=)
EP (1) EP3532628B1 (https=)
JP (2) JP2019536449A (https=)
CN (1) CN109937257B (https=)
WO (1) WO2018079684A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3960870A4 (en) 2019-03-29 2023-06-07 Ajinomoto Co., Inc. PROCESS FOR PRODUCTION OF ALLOLACTOSE
JPWO2020226087A1 (https=) 2019-05-08 2020-11-12
US12516357B1 (en) 2019-08-01 2026-01-06 Amyris, Inc. Modified host cells for high efficiency production of vanillin
WO2021085405A1 (ja) 2019-10-28 2021-05-06 味の素株式会社 ベンズアルデヒドの製造方法
CN115243561A (zh) 2020-03-04 2022-10-25 味之素株式会社 突变型转谷氨酰胺酶
BR112023005635A2 (pt) 2020-09-29 2023-04-25 Ajinomoto Kk Método e composição para produzir um alimento, transglutaminase mutante, gene, vetor, e, microrganismo
CN112980743B (zh) * 2021-04-22 2022-10-21 华南理工大学 一种枯草芽孢杆菌及其在提高酱油中4-乙基愈创木酚含量中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020806A1 (en) * 2000-09-09 2002-03-14 Degussa Ag Nucleotide sequences which code for the sahh gene
EP1507008A2 (en) * 2000-09-09 2005-02-16 Degussa AG Nucleotide sequences which code for the sahH gene
CN101255431A (zh) * 2000-03-09 2008-09-03 Basf公司 编码代谢途径蛋白的谷氨酸棒杆菌基因

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5089592A (https=) 1973-12-13 1975-07-18
JPS57134500A (en) 1981-02-12 1982-08-19 Kyowa Hakko Kogyo Co Ltd Plasmid pcg1
JPS57183799A (en) 1981-04-17 1982-11-12 Kyowa Hakko Kogyo Co Ltd Novel plasmid
JPS5835197A (ja) 1981-08-26 1983-03-01 Kyowa Hakko Kogyo Co Ltd プラスミドｐｃｇ２
JPS58192900A (ja) 1982-05-04 1983-11-10 Ajinomoto Co Inc 複合プラスミド
JPH01191686A (ja) 1988-01-26 1989-08-01 Mitsubishi Petrochem Co Ltd 複合プラスミド
FR2627508B1 (fr) 1988-02-22 1990-10-05 Eurolysine Procede pour l'integration d'un gene choisi sur le chromosome d'une bacterie et bacterie obtenue par ledit procede
US5185262A (en) 1988-07-27 1993-02-09 Mitsubishi Petrochemical Co., Ltd. DNA fragment containing gene which encodes the function of stabilizing plasmid in host microorganism
JP2678995B2 (ja) 1988-09-08 1997-11-19 三菱化学株式会社 トリプトフアンシンターゼの製造法
JPH02207791A (ja) 1989-02-07 1990-08-17 Ajinomoto Co Inc 微生物の形質転換法
JP2973446B2 (ja) 1990-01-11 1999-11-08 三菱化学株式会社 新規プラスミドベクター
JPH07108228B2 (ja) 1990-10-15 1995-11-22 味の素株式会社 温度感受性プラスミド
JPH05244941A (ja) 1992-03-03 1993-09-24 Toyo Ink Mfg Co Ltd Ｎａｄｈ依存性パラヒドロキシ安息香酸ヒドロキシラーゼ及びその製造方法
US5272073A (en) 1992-06-30 1993-12-21 Purdue Research Foundation Biocatalytic synthesis of catechol from glucose
JPH0775589A (ja) 1993-09-08 1995-03-20 Kawasaki Steel Corp プロトカテキュ酸の製造方法
AU4431196A (en) 1995-01-23 1996-08-14 Novo Nordisk A/S Dna integration by transposition
JPH0970291A (ja) 1995-06-30 1997-03-18 Ajinomoto Co Inc 人工トランスポゾンを用いた遺伝子増幅方法
JP4168463B2 (ja) 1996-12-05 2008-10-22 味の素株式会社 Ｌ−リジンの製造法
AU756507B2 (en) 1998-03-18 2003-01-16 Ajinomoto Co., Inc. L-glutamic acid-producing bacterium and method for producing L-glutamic acid
WO2000017319A2 (en) 1998-09-18 2000-03-30 Board Of Trustees Operating Michigan State University Synthesis of vanillin from a carbon source
WO2000018935A1 (en) 1998-09-25 2000-04-06 Ajinomoto Co.,Inc. Process for constructing amino acid-producing bacterium and process for producing amino acid by fermentation method with the use of the thus constructed amino acid-producing bacterium
JP2000262288A (ja) 1999-03-16 2000-09-26 Ajinomoto Co Inc コリネ型細菌の温度感受性プラスミド
EP1257649B1 (en) * 1999-06-25 2010-01-20 Paik Kwang Industrial Co., Ltd. Corynebacterium glutamicum genes encoding metabolic pathway proteins
US6759224B2 (en) 2000-09-09 2004-07-06 Degussa Ag Nucleotide sequences which code for the sahH gene
WO2004111254A1 (en) 2003-06-19 2004-12-23 Poalis A/S A method of producing a low molecular weight organic compound in a cell
DK1651758T3 (da) 2003-07-29 2008-09-01 Ajinomoto Kk Fremgangsmåde tl fremstilling af L-lysin eller L-threonin ved anvendelse af Escherichia bakterier med svækket æblesyreenzymaktivitet
JP4882063B2 (ja) 2005-10-12 2012-02-22 国立大学法人東京農工大学 テレフタル酸の代謝に関与する新規遺伝子
JP5088136B2 (ja) 2005-10-18 2012-12-05 味の素株式会社 コハク酸の製造方法
RU2418069C2 (ru) 2006-09-29 2011-05-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Способ конструирования рекомбинантных бактерий, принадлежащих к роду pantoea, и способ продукции l-аминокислот с использованием бактерий, принадлежащих к роду pantoea
US20090325244A1 (en) * 2006-10-24 2009-12-31 Basf Se Method of increasing gene expression using modified codon usage
JP2010207094A (ja) 2009-03-06 2010-09-24 Genaris Inc プロトカテク酸の製造法
CN105063104B (zh) 2011-08-08 2019-08-13 国际香料香精公司 用于香草醛或香草醛β-D-葡萄糖苷的生物合成的组合物和方法
BR112013016373B1 (pt) 2011-11-11 2021-05-18 Ajinomoto Co., Inc método para produzir uma substância alvo
AU2013339881B2 (en) 2012-11-05 2017-08-24 Danstar Ferment Ag Vanillin synthase
US20160230200A1 (en) * 2013-09-05 2016-08-11 Danmarks Tekniske Universitet Microorganisms for efficient production of melatonin and related compounds
JP6263672B1 (ja) * 2016-02-29 2018-01-17 長瀬産業株式会社 エルゴチオネインの発酵生産

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101255431A (zh) * 2000-03-09 2008-09-03 Basf公司 编码代谢途径蛋白的谷氨酸棒杆菌基因
WO2002020806A1 (en) * 2000-09-09 2002-03-14 Degussa Ag Nucleotide sequences which code for the sahh gene
EP1507008A2 (en) * 2000-09-09 2005-02-16 Degussa AG Nucleotide sequences which code for the sahH gene

Also Published As

Publication number Publication date
US11053519B2 (en) 2021-07-06
EP3532628B1 (en) 2024-02-28
CN109937257A (zh) 2019-06-25
JP2022082679A (ja) 2022-06-02
EP3532628A1 (en) 2019-09-04
US20190241915A1 (en) 2019-08-08
JP7359248B2 (ja) 2023-10-11
JP2019536449A (ja) 2019-12-19
WO2018079684A1 (en) 2018-05-03

Similar Documents

Publication Publication Date Title
CN109890972B (zh) 生产目标物质的方法
CN109937257B (zh) 生产目标物质的方法
JP7318199B2 (ja) 目的物質の製造方法
JP7331985B2 (ja) 目的物質の製造方法
CN109890960B (zh) 用于生产醛的方法
JP6881448B2 (ja) アルデヒドの製造方法
EP3406727B1 (en) Method for producing objective substance
US10883124B2 (en) Method for producing objective substance
JP7188385B2 (ja) Ｌ－メチオニンまたは合成にｓ－アデノシルメチオニンを要求する代謝物の製造方法
WO2020027251A1 (en) Method for producing objective substance

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant