CN109907319A - A kind of rice bran extract and preparation method thereof and the application in health food - Google Patents
A kind of rice bran extract and preparation method thereof and the application in health food Download PDFInfo
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Abstract
A kind of rice bran extract and preparation method thereof and the application in health food, the rice bran extract is using rice bran as raw material, pass through ethanolic extraction, the auxiliary extracting of enzyme and ultrasonic wave assisted extraction wherein biologically active substance after polishing, the content > 1.2mg/g of Rice Bran Flavonoid in rice bran extract object.The invention also includes the preparation methods of rice bran extract.The resource utilization of present invention realization rice bran；Guarantee that ethyl alcohol extracts the effect of active matters of rice bran matter, extracted product purity is high, and extraction efficiency is high, and operating method is simple, extraction time is short, low to apparatus for preparation requirement, and intermediate product and final product are nontoxic, it is highly-safe, there is broad mass market prospect, convenient for batch production；A kind of the present invention provides paddy by-product after ridge paddy machine is milled and the method for rice bran resource utilization discarded.Invention also provides a kind of demands for meeting consumer to the health food for improving memory function.
Description
Technical field
The present invention relates to a kind of rice bran extraction processes, and in particular to a kind of rice bran extract and preparation method thereof and in health care
Application in food.
Background technique
Rice bran is that a kind of brown rice is milled byproduct made from (polishing) process, is had very high nutritive value.But
Be, due to fat content is high, containing the environmental contaminants in various enzymes and mill processes, it quickly can souring rot.Moreover, only
10% rice bran for accounting for brown rice total weight is realistically distributed in mill processes and its availability is very low, and most of rice sugar removes
It is used as outside feed or fertilizer and is all discarded.Although rice bran, there is these disadvantages, rice bran biology rich in is living
Property ingredient such as Rice Bran Flavonoid, rice bran polysaccharide, tocopherol, vitamin B complex, vitamin E etc., wherein Rice Bran Flavonoid is in rice bran
Most important one kind compound, and more a kind of compound was studied in recent years, this compound is with 2- phenyl chromogen
Ketone is parent nucleus, it includes 4H-1-Benzopyran-4-one, 2- (3,4-dihydroxyphenyl) -3,5,7-
trihydroxy-Flavone、4'',5,7-Trihydroxyflavanone、2-(3,4-Dihydroxyphenyl)-3,5,7-
The substances such as trihydroxychromenylium.
CN 107137619A discloses a kind of anti-breast cancer health care product containing Rice Bran Flavonoid, by following raw material by weight hundred
Divide than composition: Rice Bran Flavonoid 50-70%, Radix Morindae Officinalis extract 5-10%, Radix Aristolochiae extract 5-10%, extract of Zhuling 5-
10%, Shorthorned Epimedium P.E 5-10%, bupleurum extract 5-10%.Pass through the experimental study to people's breast cancer cells ira vitro, hair
The composition of existing Rice Bran Flavonoid has good inhibiting effect to tumor cell in vitro, has for the prevention and treatment of breast cancer very aobvious
The effect of work.The preparation method that Rice Bran Flavonoid is mentioned in the invention is to digest after rice bran powder is dissolved in water, then assisted with ethyl alcohol
It extracts, the active matters of rice bran matter that can be extracted is limited, and Rice Bran Flavonoid purity and recovery rate are also to be improved.
CN 106983830A discloses a kind of antidepression health care product containing Rice Bran Flavonoid, by following raw material percentage by weight
Than composition: Rice Bran Flavonoid 50-70%, Magnolia cortex P.E 5-10%, lucid asparagus extract 5-10%, pulp of dogwood fruit extract 5-
10%, Notogineng Extract 5-10%, Bitter Orang P.E 5-10%.Pass through the experimental study to external depression model cell, discovery
The composition of Rice Bran Flavonoid has preferable protective effect to cell, has better effects for the prevention and treatment of depression, can be to avoid
Toxic side effect caused by excessive chemical synthetic drug.It is that rice bran powder is molten that the preparation method of Rice Bran Flavonoid is mentioned in the invention
Enzymatic hydrolysis carries out hot water extraction after water, then with ethyl alcohol assisted extraction, the active matters of rice bran matter that can be extracted is also limited, Rice Bran Flavonoid
Purity and recovery rate are also to be improved.
Rice bran extract not only has antioxidation, can reduce injury of the oxidative stress effect to cell；Also have anti-
Inflammatory effect can prevent the transmitting of inflammatory factor in the cell, to reduce the apoptosis of nerve cell, can effectively remove freedom
Base has highly important effect for anti-aging, and in anticancer, antibacterial, reduction blood glucose, blood lipid etc. can also play a variety of
Biological action.Therefore, some functional food rice brans can be made using rice bran extract as core functionality raw material to mention
Object is taken to can be used as the high-quality raw material of health food.
Despite this, up to the present, there are not the disclosed or well known extraction bioactive ingredients from rice bran
Rice bran extract is not also applied to improve the application of memory function by method.
Summary of the invention
The technical problem to be solved by the present invention is to overcome drawbacks described above of the existing technology, provide a kind of extraction
Yield is higher, and physiological activity is higher, is easy to be absorbed by organisms the rice bran extract utilized.
The further technical problems to be solved of the present invention are to overcome drawbacks described above of the existing technology, provide one kind and mention
Take high-efficient, extraction time is shorter, requires lower, the preparation method of highly-safe rice bran extract to apparatus for preparation.
Further, the present invention also provides the rice bran extracts in the health food for improving memory function for teenager
Purposes.
Further, the present invention also provides the rice bran extracts to improve memory function prevention senile dementia for person in middle and old age
Health food in purposes.
Further, the present invention provides the rice bran extract for anti-aging, anti-oxidant and strengthen immunity health care
Purposes in food.
The technical solution adopted by the present invention to solve the technical problems is as follows: a kind of rice bran extract, using rice bran as raw material
Pass through ethanolic extraction, the auxiliary extracting of enzyme and ultrasonic wave assisted extraction wherein biologically active substance, the rice after polishing
The content > 1.2mg/g of Rice Bran Flavonoid in chaff extract object.
The present invention further solves technical solution used by its technical problem: a kind of preparation side of rice bran extract
Method, comprising the following steps:
(1) rice bran is polished: rice bran impurity elimination being ground, sieving obtains rice bran coarse powder；
(2) ethanolic extraction: rice bran coarse powder obtained by step (1) is placed in stuffed conical flask, and rice bran meal quality 20~40 is added
Ethanol solution again extracts 1~2h, obtains rice bran ethyl alcohol and extracts solution；
(3) the auxiliary extracting of enzyme: extracting solution heating water bath for rice bran ethyl alcohol obtained by step (2), until rice-bran crude is added in 60 DEG C of whens
The cellulase of silty amount 4~6% adjusts pH value 6~8, and after digesting 1.5~2h, boiling water bath inactivates 15~20 min, obtains rice
Chaff enzymolysis and extraction solution；
(4) ultrasonic wave assisted extraction: rice bran ethyl alcohol obtained by step (3) is extracted enzymatic hydrolysis solution and is placed in ultrasonic cleaner and is shaken
It extracts, obtains rice bran ultrasonic extraction solution.
(5) centrifugal concentrating: rice bran ultrasonic extraction solution obtained by step (4) is placed in a centrifuge, supernatant is taken after centrifugation
It is concentrated with Rotary Evaporators, obtains rice bran and extract concentrate.
(6) it is freeze-dried: by the extraction concentrate freeze-drying of rice bran obtained by step (5).
Further, rice bran described in step (1) is by-product of the long-grained nonglutinous rice paddy after ridge paddy machine is milled.
Further, sieving described in step (1) is 50~70 meshes.
Further, the volume fraction of ethanol solution described in step (2) is 70~80%.
Further, the power of ultrasonic cleaner described in step (4) be 100~300W, ultrasonic time be 120~
140min。
Further, in step (5) centrifuge 3000~5000 r/min of power, centrifugation time be 10~15 min.
The extraction yield of Rice Bran Flavonoid is higher in rice bran extract of the present invention, content > 1.2mg/g, has excellent antioxygen
The physiological activity such as change, anti-radiation, antitumor have quenching activity oxygen, eliminate human free radical, is anti-aging, protection skin, prevention
Heart disease slows down the different physiological roles such as atherosclerosis, protection angiocarpy, pre- anti-cancer, and performance safety is reliable, does not have
Side effect has a very wide range of applications prospect in food, skin care item and field of medicaments.
The invention has the advantages that: (1) using the byproduct rice bran of paddy processing as raw material, and therefrom extracting has biology living
The content > 1.2mg/g of property substance such as Rice Bran Flavonoid, realizes the resource utilization of rice bran；(2) it utmostly ensure that ethyl alcohol mentions
The effect of active matters of rice bran matter is taken, extracted product purity is high, and extraction efficiency is high, and operating method is simple, and extraction time is short,
Low to apparatus for preparation requirement, intermediate product and final product are nontoxic, highly-safe, therefore have broad mass market prospect, convenient for criticizing
Amount production；(3) provide a kind of purposes in the health food for improving memory function for teenager of rice bran extract or with
Improve the purposes in memory function prevention senile dementia or anti-aging, anti-oxidant, strengthen immunity health food in person in middle and old age.
Specific embodiment
Below with reference to embodiment, the invention will be further described.
Chemical reagent used in the embodiment of the present invention is obtained by routine business approach unless otherwise specified.
Embodiment 1
The preparation method of the present embodiment rice bran extract, comprising the following steps:
(1) rice bran is polished: rice bran being ground into rice bran powder, crosses 60 meshes, rice bran coarse powder is made.
(2) ethanolic extraction: weighing 2.000g rice bran coarse powder in 250ml stuffed conical flask with assay balance, and 80ml is added
The ethanol solution that volumetric concentration is 75% extracts 1.5h.
(3) the auxiliary extracting of enzyme: being placed in 60 DEG C of water-baths and heat, addition when fluid temperature in conical flask reaches 60 DEG C
Rice bran meal quality is stirred evenly than the cellulase for 5%, with HCl standard solution and NaOH standard solution adjust pH value to
7.0,60 DEG C of water-bath 1.5h；Conical flask, which is placed in 15 min of water-bath at 90 DEG C, makes enzyme-deactivating.
(4) ultrasonic wave assisted extraction: the rice bran solution after water-bath is placed in the ultrasonic cleaner of 200 W of power, is surpassed
The sound time is 120 min.
(5) centrifugal concentrating: being centrifuged after ultrasound, and the power of centrifuge is 4000 r/min, is centrifuged 10min, is taken supernatant
Liquid is concentrated with Rotary Evaporators,
(6) it is freeze-dried: then concentrate being freeze-dried, obtains rice bran extract.
The content of the Rice Bran Flavonoid of the rice bran extract prepared in the present embodiment is 1.25mg/g.
Embodiment 2
The preparation method of the present embodiment rice bran extract, comprising the following steps:
(1) rice bran is polished: rice bran being ground into rice bran powder, crosses 60 meshes, rice bran coarse powder is made.
(2) ethanolic extraction: weighing 2.000g rice bran coarse powder in 250ml stuffed conical flask with assay balance, and 80ml is added
The ethanol solution 1.5h that volumetric concentration is 74%.
(3) the auxiliary extracting of enzyme: being placed in 60 DEG C of water-baths and heat, addition when fluid temperature in conical flask reaches 60 DEG C
Rice bran meal quality is stirred evenly than the cellulase for 4%, with HCl standard solution and NaOH standard solution adjust pH value to
7.0,60 DEG C of water-bath 1.5h；Conical flask, which is placed in 15 min of water-bath at 90 DEG C, makes enzyme-deactivating.
(4) ultrasonic wave assisted extraction: the rice bran solution after water-bath is placed in the ultrasonic cleaner of 200 W of power, is surpassed
The sound time is 120 min.
(5) centrifugal concentrating: being centrifuged after ultrasound, and the power of centrifuge is 4000 r/min, is centrifuged 10min, is taken supernatant
Liquid is concentrated with Rotary Evaporators,
(6) it is freeze-dried: then concentrate being freeze-dried, obtains rice bran extract.
The content of the Rice Bran Flavonoid of the rice bran extract prepared in the present embodiment is 1.3mg/g.
Embodiment 3
The preparation method of the present embodiment rice bran extract, comprising the following steps:
(1) rice bran is polished: rice bran being ground into rice bran powder, crosses 60 meshes, rice bran coarse powder is made.
(2) ethanolic extraction: weighing 2.000g rice bran coarse powder in 250ml stuffed conical flask with assay balance, and 100ml is added
The ethanol solution 1.5h that volumetric concentration is 77%.
(3) the auxiliary extracting of enzyme: being placed in 60 DEG C of water-baths and heat, addition when fluid temperature in conical flask reaches 60 DEG C
Rice bran meal quality is stirred evenly than the cellulase for 6%, with HCl standard solution and NaOH standard solution adjust pH value to
7.0,60 DEG C of water-bath 1.5h；Conical flask, which is placed in 15 min of water-bath at 90 DEG C, makes enzyme-deactivating.
(4) ultrasonic wave assisted extraction: the rice bran solution after water-bath is placed in the ultrasonic cleaner of 200 W of power, is surpassed
The sound time is 120 min.
(5) centrifugal concentrating: being centrifuged after ultrasound, and the power of centrifuge is 4000 r/min, is centrifuged 10min, is taken supernatant
Liquid is concentrated with Rotary Evaporators,
(6) it is freeze-dried: then concentrate being freeze-dried, obtains rice bran extract.
The content of the Rice Bran Flavonoid of the rice bran extract prepared in the present embodiment is 1.5mg/g.
The present embodiment, which prepares rice bran extract application D- galactolipin, which intends dementia mice progress rice bran extract, is improving memory
The validity check of function.
Modeling method: from animal factor induction property memory impairment, quasi- dementia mice is manufactured using injection of d-galactose
Model, abbreviation D- galactolipin intend dementia mice model.
1 material
1.1 animal
Male ICR mouse 70,22.0~25.0g of weight, animal quality quality certification number: 43004700042902, it is purchased from Hunan
This Lake scape reaches experimental animal Co., Ltd, experimental animal production licence number: the Hunan SCXK() 2011-0003；In Hunan Province's medicine
The raising of object Research on Safety Assessment center barrier environment, experimental animal use credit number: the Hunan SYXK() 2015-0016.
1.2 rice bran extracts and reagent
The rice bran extract obtained by the present embodiment, the content of Rice Bran Flavonoid are 1.5mg/g.
0.9% sodium chloride injection (lot number: 20170112, Hunan Kangyuan Pharmacy Co., Ltd.'s product)；
D- galactolipin (lot number: C10110341, MACKIN Products).
1.3 instrument
Morris water maze, Chengdu Tai Meng science and technology Co., Ltd product；New object identification system, Shanghai Ji amount science and technology are limited
Products.
2 methods
The foundation of 2.1 animal packets and animal model
Male ICR mouse 70,22.0~25.0g of weight, model control group, donepezil (3.0mg/ are randomly divided by weight
Kg) group, rice bran extract be low, high dose group (100mg/kg, 200mg/kg), every group 10, separately takes 10 mouse as normal
Control group.Remaining mouse subcutaneous injection D- galactolipin 120mg/kg, 1 time a day, 70 days continuous (10 weeks), Normal group nape
0.9% isometric sodium chloride injection of portion's subcutaneous injection, after injecting 14 days (2 weeks), corresponding medical fluid is given in stomach-filling to each group respectively,
Administered volume is 20mL/kg, successive administration 8 weeks, successive administration 8 weeks, respectively at administration 5 weeks and after the last administration each group mouse into
Row water maze and the detection of new object identification behaviouristics.
Platform is fixed on the center of the 2nd quadrant by 2.2 Morris water maze laboratories, is injected tap water in pond, is poured into
White dye keeps platform invisible, and water level is higher than platform 1.5cm.Water temperature stability is at 25 DEG C ± 1 DEG C in experimentation.Every daily
Animal testing 3 times, first animal is placed on platform before test and adapts to 10s, randomly select 3 place of entry, 60s is detected, if finding
Platform then allows it to stop 10s on platform to return cage again, and to platform, stopping 10s(incubation period is denoted as guidance if not finding platform
60s).System automatically records time (escape latency/total time), the target quadrant residence time, target that animal finds platform
The indexs such as quadrant distance, total distance, average speed.Remove platform within 4th day, from the diagonal quadrant midpoint of former real platform by animal towards
Into the water, system record animal passes through the number (wearing platform number) of former real platform quadrant, total distance, average speed to pool wall in 60s
The indexs such as degree.
2.3 new object identification experiments experiment processes are divided into 3 stages: laundering period, the phase of being familiar with, test phase.Laundering period is 3
Animal, is sequentially placed into experimental box by it daily, is familiar with 10 min of environment.After laundering period, next day is familiar with and is tested.
When being familiar with the phase, two identical objects are put into experimental box to fixed, the interior exploration row to two articles of record mouse 5min
For.After being spaced 30 min, into the test phase.In the test phase, by one of familiar objects change position, be moved to it is another ripe
It knows and is fixed at the catercorner magnet of object.Mouse is recorded to the exploration time of novel object and familiar objects, uses index of discrimination
(discrimination index, DI) evaluates the ability of learning and memory of animal.
2.4 statistical methods are for statistical analysis using SPSS16.0, the level set of statistical significance be P≤
0.05, measurement data using mean ± standard deviation () indicate, normality and homogeneity of variance are examined with Leven ' s test method,
If meeting normality and homogeneity of variance (P > 0.05), statistical is carried out with one-way analysis of variance (ANOVA) and LSD test
Analysis；If not meeting normality and homogeneity of variance (P≤0.05), examined with Kruskal-Wallis, if Kruskal-
Wallis examines statistically significant (P < 0.05), then with Dunnett ' s Test(nonparametric technique) it is compared analysis.It comments
Statistical difference and biological significance are considered when valence.
3. result
3.1 rice bran extracts manufacture the influence of quasi- dementia mice model M orris water maze orientation navigation experiment to D- galactolipin
1 rice bran extract of table is on the preclinical influence of mouse orientation navigation
Note: the * compared with Normal groupP< 0.05, * *P< 0.01, the * compared with model control groupP< 0.05, * *P<0.01。
As shown in table 1, compared with Normal group, orientation navigation D1, D3 days model control group mouse is gone up on the stage after administration 9 weeks
Incubation period is obviously prolonged (P < 0.05 or P < 0.01)；Compared with model control group, 8 weeks rice bran extract low dose group mouse are administered
Orientation navigation D3 incubation period significantly reduces (P < 0.05).Donepezil group mouse orientation navigation D2 incubation period significantly reduce (P <
0.05).
3.2 rice bran extracts manufacture the influence of quasi- dementia mice model space explorative experiment to D- galactolipin
Influence of 2 rice bran extract of table to mouse space exploration target quadrant time, distance, spanning platform number
Note: the * compared with Normal groupP< 0.05, *P< 0.01, the * compared with model control groupP< 0.05, * *P<0.01。
As shown in table 2, compared with Normal group, it is obvious that model control group is administered 5 weeks, 8 weeks mouse pass through platform number
It reduces (P < 0.05), compared with model control group, rice bran extract is low, high dose group mouse passes through platform number and significantly reduces (P
< 0.05).Donepezil group mouse significantly reduces (P < 0.05) by platform number.
Influence of 3 rice bran extract of table to mouse space exploration target quadrant time, distance, spanning platform number
Note: the * compared with Normal groupP< 0.05, * *P< 0.01, the * compared with model control groupP< 0.05, * *P<0.01。
As shown in table 3, compared with model control group, rice bran extract low dosage is administered 5 weeks total distance, speed and obviously increases
(P < 0.05).
3.3 rice bran extracts manufacture the shadow of the quasi- new object identification behaviouristics test experience of dementia mice model to D- galactolipin
It rings
Influence of 4 rice bran extract of table to mouse index of discrimination
Note: the * compared with Normal groupP< 0.05, * *P< 0.01, the * compared with model control groupP< 0.05, * *P<0.01。
As shown in table 4, compared with Normal group, model control group mouse index of discrimination be substantially reduced (P < 0.05 or P <
0.05)；Compared with model control group, administration 5 weeks after, rice bran extract is low, high dose mouse index of discrimination be substantially reduced (P <
0.05 or P < 0.01)；Rice bran extract low dosage mouse index of discrimination is substantially reduced (P < 0.05 or P < 0.01) after being administered 8 weeks,
Positive control drug donepezil piece group mouse index of discrimination is substantially reduced (P < 0.05 or P < 0.01).
In conclusion rice bran extract prepared by the present invention is low, high dose group can be obviously improved galactolipin and cause reference memory
Damage can be obviously improved galactolipin and cause non-space memory impairment.Experiment shows that rice bran extract intends dementia mice to D- galactolipin
Model learning memory tool improves significantly, and has biggish market prospects and application value.
Claims (10)
1. a kind of rice bran extract, which is characterized in that using rice bran as raw material, pass through the auxiliary extracting of ethanolic extraction, enzyme after polishing
With ultrasonic wave assisted extraction wherein biologically active substance, the content > of Rice Bran Flavonoid in the rice bran extract object
1.2mg/g。
2. a kind of preparation method of rice bran extract as described in claim 1, which comprises the following steps:
(1) rice bran is polished: rice bran impurity elimination being ground, sieving obtains rice bran coarse powder；
(2) ethanolic extraction: rice bran coarse powder obtained by step (1) is placed in stuffed conical flask, and rice bran meal quality 20~40 is added
Ethanol solution again extracts 1~2h, obtains rice bran ethyl alcohol and extracts solution；
(3) the auxiliary extracting of enzyme: extracting solution heating water bath for rice bran ethyl alcohol obtained by step (2), until rice-bran crude is added in 60 DEG C of whens
The cellulase of silty amount 4~6%, adjusting pH value is 6~8, and after digesting 1.5~2h, boiling water bath inactivates 15~20 min, obtains rice
Chaff enzymolysis and extraction solution；
(4) ultrasonic wave assisted extraction: rice bran ethyl alcohol obtained by step (3) is extracted enzymatic hydrolysis solution and is placed in ultrasonic cleaner and is shaken
It extracts, obtains rice bran ultrasonic extraction solution；
(5) centrifugal concentrating: rice bran ultrasonic extraction solution obtained by step (4) is placed in a centrifuge, and supernatant is taken to revolve after centrifugation
Turn evaporimeter to be concentrated, obtains rice bran and extract concentrate；
(6) it is freeze-dried: rice bran obtained by step (5) being extracted into concentrate and is freeze-dried up to rice bran extract.
3. the preparation method of rice bran extract according to claim 2, which is characterized in that rice bran described in step (1) is Xian
By-product of the rice paddy after ridge paddy machine is milled.
4. the preparation method of rice bran extract according to claim 2, which is characterized in that sieving described in step (1) is 50
~70 meshes.
5. according to Claims 2 or 3 or the preparation method of 4 rice bran extracts, which is characterized in that second described in step (2)
The volume fraction of alcoholic solution is 70~80%.
6. the preparation method of the rice bran extract according to one of claim 2~5, which is characterized in that surpass described in step (4)
The power of sound wave washer is 100~300W, and ultrasonic time is 120~140min.
7. the preparation method of the rice bran extract according to one of claim 2~6, which is characterized in that centrifugation in step (5)
3000~5000 r/min of power of machine, centrifugation time are 10~15 min.
8. application of the rice bran extract in the health food for improving memory function for teenager according to claim 1.
9. rice bran extract is in the health care food for improving memory function prevention senile dementia for person in middle and old age according to claim 1
Application in product.
10. rice bran extract is in for anti-aging, anti-oxidant and strengthen immunity health food according to claim 1
Application.
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| CN111440767A (en) * | 2020-04-24 | 2020-07-24 | 尚禾粒线体生物科技(深圳)有限公司 | Mitochondrial protective agent and application thereof |
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Application publication date: 20190621 |