CN110074392A - A kind of Antialcoholic liver-protecting nourishing the stomach shield intestines composition and preparation method thereof - Google Patents

A kind of Antialcoholic liver-protecting nourishing the stomach shield intestines composition and preparation method thereof Download PDF

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Publication number
CN110074392A
CN110074392A CN201910304163.1A CN201910304163A CN110074392A CN 110074392 A CN110074392 A CN 110074392A CN 201910304163 A CN201910304163 A CN 201910304163A CN 110074392 A CN110074392 A CN 110074392A
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liver
parts
stomach
zinc
nourishing
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逯家辉
朱晏锋
王迪
王助乾
张静茹
肖洋
刘燕隔
滕乐生
孟庆繁
滕利荣
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Jilin University
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Jilin University
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/14—Yeasts or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/175—Rhamnosus

Abstract

The invention discloses a kind of Antialcoholic liver-protecting nourishing the stomach to protect intestines composition; there are reparation and protective effect to stomach lining using hickory chick, Hericium erinaceus, Boletus aereus; assistant can be with stachyose together as stomach probiotics nutriment with polysaccharide; enteron aisle is directly protected; to indirect protection liver, polysaccharide can also promote the absorption of Zinc-rich saccharomyces cerevisiae, and zinc is the important substance for forming a variety of enzymes in liver; organic zinc in Zinc-rich saccharomyces cerevisiae is more easily absorbed by the body, and liver is directly protected.It complements each other between raw material, a variety of reactions can occur during the preparation process, unexpected pharmacodynamic effects are such as generated to act synergistically by the bonding again of hydrogen bond, Van der Waals force and chemical bond.

Description

A kind of Antialcoholic liver-protecting nourishing the stomach shield intestines composition and preparation method thereof
Technical field
The invention belongs to technical field of health care food more particularly to a kind of Antialcoholic liver-protecting nourishing the stomach to protect intestines composition, simultaneously also Provide preparation method.
Background technique
Spirits culture is the important component of Chinese nation's cooking culture, it has also become the indispensable work of people's social activities Tool.After human body is drunk, alcohol is fat-soluble liquid, without digestion, is directly absorbed into blood rapidly, complete in two hours It absorbing, wherein 20% alcohol is absorbed by stomach, and has part to carry out first-pass metabolism, remaining 80% is absorbed by duodenum and jejunum, The alcohol of absorption of human body, which is quickly distributed to whole body, respectively to be organized.Authoritative medical journal " lancet " research, alcohol user gently then cause dusk It sleeps and various automatisms, it is heavy then even cause alcoholism dead.With going deep into for research, the machine of alcohol harmful to human It is more and more clear to make.Liver is the major organs for being metabolized alcohol, and alcohol is catalyzed through alcohol dehydrogenase in liver (ADH) and generates second Aldehyde, acetaldehyde are further oxidized to nontoxic acetic acid by the acetaldehyde dehydrogenase (ALDH) in liver mitochondrion, ultimately generate titanium dioxide Carbon and energy.But liver metabolism alcohol speed is slow, and alcohol has cytotoxicity, and an excessive consumption of alcohol causes liver to be difficult to fastly Speed metabolism, alcohol accumulation liver can make liver plasma membrane surface lipids peroxidating, destroy liver plasma membrane, further development can make liver thin The structures such as micro-pipe and mitochondria intracellular are destroyed, and intracellular metabolic disorder is made, and lead to have cytotoxic metabolism production Object acetaldehyde generates, so as to cause swelling of liver cell, necrosis.
Stomach is the vitals that ethyl alcohol more early contacts, and ethyl alcohol also becomes domestic and foreign scholars' research to the damage mechanisms of stomach lining One of important topic.There is pertinent literature confirmation, it is to carry out in liver, but also have small part to exist that ethyl alcohol is metabolized 90% in vivo It is oxidized in alimentary canal, i.e., is oxidized metabolism in stomach, this phenomenon becomes the first-pass metabolism of ethyl alcohol, its main feature is that for ethyl alcohol Absorptivity it is very sensitive.Long-term alcohol can make stomach lining alcohol dehydrogenase (ADH) activity decline, and gastric acid is made to reduce and promote Bacterial growth causes to accelerate gastric emptying, ethyl alcohol is caused to contact reduction with gastric alcohol dehydrogenase (ADH), final to inhibit alcohol in stomach The first-pass metabolism in portion makes more ethyl alcohol enter blood circulation by intestinal absorption.
Intestinal mucosal barrier is the important immune defense barrier of body, it can by enteron aisle exogenous material and body every Open, body enable to resist the intrusion of pathogenic microorganism and the damage of antigen molecule, mainly include enterocyte barrier, Immunization barrier and microbial barrier, midgut epithelial cell barrier are most important one of barriers.And long-term alcohol will lead to intestines Mucosal villi shortens, or even atrophy phenomenon occurs, keeps intestinal mucosal barrier impaired.Intestinal endotoxin and its activation Hepatic kupffer cells Inflammatory factor is generated, related document confirms that alcohol serves not only as liver toxic agent, can weaken metabolism and the liver cell of normal liver cell Stability, damage mitochondrial function, while alcohol can cause intestinal permeability to increase, make gut derived exndotoxin leak to be formed it is secondary Attack aggravates hepatic injury.
Through state food pharmaceuticals administration general bureau (CFDA) --- health food website " data query " column has been announced Health food information be data source, and with " having assistant protection function to chemical damage " be keyword carried out China Ratify health food data collection.Ricipe for health care food type, dosage form, healthcare function, functional component are counted respectively, It is effectively collected in health food in 325 altogether, while there is " having assistant protection function to chemical damage " and " have to gastric mucosa The product of assistant protection function " only has 11 kinds, and the health food that three kinds of internal organs of liver sausage stomach are protected there is no.
Edible mushroom is considered to have nutrition, nourishing and pharmacological function.In recent years, the alimentary health-care function of edible mushroom is studied Very fast development is arrived, modern medicine study shows that edible mushroom primary healthcare function has the organism balance for adjusting human body, improves body Immunoregulation capability improves blood circulation, enhances cardiovascular function, and prevention cancer cell is formed, and has certain protection to make in liver With, and have the effects that stomach invigorating is aid digestion.Currently, edible fungus is mainly with the preliminary working product such as dried product, snack food Main, intensive processing product is few, using modern high technology technique, such as fermentation technique, promotes edible fungi nutrition and health care function The sustainable development that can be studied.The complicated component of edible mushroom, function are also presented diversified trend, heterogeneity functional characteristics and The different physiological activity difference of different mushroom substances of the same race is very different, the characteristics of having function diversification, specify ingredient mechanism.
Summary of the invention
The present invention provides a kind of Antialcoholic liver-protecting nourishing the stomach shield intestines composition and preparation method thereof, by hickory chick, Hericium erinaceus, black Bolete is primary raw material, is aided with Lactobacillus rhamnosus with synergy, stachyose, Zinc-rich saccharomyces cerevisiae, is crushed using broken wall Technology, full nutrition multicomponent systemization intervene the health food of human liver stomach.By probiotics in paraphyte, enteron aisle screen is repaired Barrier absorbs edible fungi polysaccharide, improves cytokine levels, and protection stomach lining, is protected liver supplement Zn-ef ficiency, thus Reduce harm of the ethyl alcohol to human body.Reaching disintoxicating product on alleviation existing market is mainly chemicals and Chinese materia medica preparation, and is changed Learning class product, there are toxic side effects, and traditional Chinese medicine effect is slow, the bad technical problem of alcohol user's compliance.And fill up no liver The blank for crowd's product of drinking that stomach is protected jointly.
To achieve the goals above, the present invention adopts the following technical scheme:
Intestines composition is protected in a kind of liver-protecting sobering up nourishing the stomach, it is characterised in that is made of following raw material:
10-30 parts of hickory chick, 10-20 parts of Hericium erinaceus, 10-20 parts of Boletus aereus, 1-10 parts of Lactobacillus rhamnosus, stachyose 1-10 Part, 1-5 parts of Zinc-rich saccharomyces cerevisiae.
Further, Antialcoholic liver-protecting nourishing the stomach shield intestines composition is prepared into tablet health food.
A kind of method for preparing tablet thereof of Antialcoholic liver-protecting nourishing the stomach shield intestines composition, includes the following steps:
Weigh 10-30 parts of hickory chick, 10-20 parts of Hericium erinaceus, 10-20 parts of Boletus aereus, 1-10 parts of Lactobacillus rhamnosus, stachyose 1-10 parts, 1-5 parts of Zinc-rich saccharomyces cerevisiae, are sufficiently mixed to obtain component mixture；Said mixture is carried out by three-dimensional colloid mill Grinding, minimum grain size are 0.1-1 μm, then by spray drying, mix, softwood processed, granulation, after tabletting, tablet be made.
Six kinds of first wifves such as the selected hickory chick of the present invention, Hericium erinaceus, Boletus aereus expect combination collocation, and proportion is real by animal Test its reasonability of scientific validation.Raw material is food materials, greatly improves the safety of product, is set about from whole, using edible mushroom, The full nutrition multicomponent combination solid of the multiple-microorganisms cell such as yeast, probiotics, liquid micronized pulverization technology damage human liver Wound, gastrointestinal mucosa carry out system intervention, restore it thoroughly.
In prescription of the present invention, hickory chick has help digestion stomach function regulating, liver protection and other effects.Hericium erinaceus, also known as Hericium erinaceus are famous Dual-purpose of drug and food fungi；It is recorded according to Compendium of Material Medica and " China's book on Chinese herbal medicine ", Hericium erinaceus is mild-natured, sweet in flavor, clinically main at present to use In treatment gastric duodenal ulcer, chronic gastritis and tumor in digestive tract etc..Boletus aereus has the effects that protect liver, anticancer.Benefit Raw bacterium can be colonized in enteron aisle, metabolite and active material by formed chemical barrier it is changeable in the pH value of environment, oxygen Change reduction potential, and then directly inhibit the generation of harmful bacteria, improves the quantity of beneficial bacterium；In addition, probiotics can be made by exclusion With biological containment is formed, so that harmful bacteria be inhibited to echo production in enteron aisle interior suction, intestinal flora balance is maintained.Related document card Real, probiotics can stimulate the growth of beneficial bacterium in enteron aisle, and inhibit pathogenic bacteria to grow in enteron aisle through a variety of ways, reduce The field planting of pathogenic bacteria and Adhering capacity, so as to improve intestinal barrier function.Existing immunological regulation in body can also be adjusted and exempted from Epidemic disease stimulation inducing macrophage and lymphocyte generate cell factor, improve immunity of organisms.Numerous studies confirm, a variety of Probiotics has good antioxidant activity and free radical scavenging ability, plays a significant role to body antioxidant levels are improved, And there are potential protective effects to liver.Lactobacillus rhamnosus is to study a kind of probiotics the most thorough, relative to other The ability of its environment of resistance to intestinal acidity is stronger for probiotics, only generates Pfansteihl during the fermentation without other acids, therefore It is without side-effects to human body.It is able to maintain that intestinal flora balance, improves gut barrier function, adjusts immunity of organisms, and to wine Essence hepatopathy has significant protective effect.Stachyose is as emerging functional oligose, because it is delaying senescence, is adjusting stomach Intestinal microecology balance has physiological function in terms of improving immunity, Antialcoholic liver-protecting, and development and application is paid more and more attention. Zinc is one of the essential trace elements of the human body, zinc-deficiency often occurs in patient body and in alcoholic liver disease animal model in excessive drinking The case where.Clinical research shows that Zn content is lower in the serum and liver of alcoholic liver disease patient, this subtracts with zinc-iron alloy solution in enteron aisle The excretion of few and urine zinc increases related；The a large amount of liver gene for participating in various kinds of cell function will receive the influence of zinc-deficiency, root It is past accordingly studies have shown that supplement zinc can prevent caused hepatic injury of indulging in excessive drinking, and liver caused by can controlling because of alcohol aoxidizes Stress reaction, and play a role in liver regeneration.Zinc-rich saccharomyces cerevisiae is a kind of important zinc nutrition replenishers, it be with Yeast is carrier, and zinc is independently absorbed and converted during the growth process by yeast, makes zinc and the intracorporal biology point of yeast Son organically combines, and a kind of zinc of biological state is formed, so that the inorganic zinc and organic zinc that eliminate traditional chemical property are to human body Toxicity and stomach stimulation, also enable that zinc is more efficient, is more safely absorbed and utilized by the body.
Of the invention has an advantageous effect in that
There are reparation and protective effect to stomach lining using hickory chick, Hericium erinaceus, Boletus aereus, assistant can be with stachyose one with polysaccharide It rises and is used as stomach probiotics nutriment, enteron aisle is directly protected, thus indirect protection liver, polysaccharide can also promote zinc-rich ferment Female absorption, zinc are the important substances for forming a variety of enzymes in liver, and the organic zinc in Zinc-rich saccharomyces cerevisiae is more easily absorbed by the body, for liver It is dirty directly to be protected.It complements each other between raw material, a variety of reactions can occur during the preparation process, such as pass through hydrogen bond, Van der Waals The bonding again of power and chemical bond generates unexpected pharmacodynamic effects to act synergistically.
Antialcoholic liver-protecting nourishing the stomach shield intestines composition of the present invention crushes the mode combined with liquid cellular using solid cellular, Under the premise of so that consumer is easier to absorption, maximum remains the activity of the multicomponent among raw material, complete nutrition ingredients and utmostly Generation pharmacodynamics value, make product better effect.
The use easy to carry of intestines composition is protected in Antialcoholic liver-protecting nourishing the stomach of the present invention, and drug action is obvious, can not only play and relieve the effect of alcohol The effect of liver protection, but also intestinal flora composed structure can be improved, protective effect is played to gastric mucosa, there is good guarantor Strong effect.
Detailed description of the invention
Influence of Fig. 1 present composition to AST level in serum；
Influence of Fig. 2 present composition to serum alt level；
The influence that Fig. 3 present composition changes liver pathology；
Influence of Fig. 4 present composition to PEG2 level in stomach；
Influence of Fig. 5 present composition to stomach pathological change；
Influence of Fig. 6 present composition to LPS level in serum；
Influence of Fig. 7 present composition to intestines pathological change.
Specific embodiment
Technical solution of the present invention is described further combined with specific embodiments below, in order to same domain technical staff Understanding, but do not limit interest field of the invention.
Embodiment 1
It is weighed in the following manner with the parts by weight of each raw material: 10 parts of hickory chick, 20 parts of Hericium erinaceus, 20 parts of Boletus aereus, sandlwood 1 part of sugared lactobacillus, 5 parts of stachyose, 1 part of Zinc-rich saccharomyces cerevisiae, are sufficiently mixed to obtain component mixture.Said mixture is successively passed through Micronizer and three-dimensional colloid mill are crushed and are ground, and final emulsion minimum grain size is 0.1-1 μm, are then passed through Spray drying mixes, softwood processed, granulation, after tabletting, tablet is made.
Embodiment 2
It is weighed in the following manner with the parts by weight of each raw material: 20 parts of hickory chick, 10 parts of Hericium erinaceus, 15 parts of Boletus aereus, sandlwood 5 parts of sugared lactobacillus, 1 part of stachyose, 3 parts of Zinc-rich saccharomyces cerevisiae, are sufficiently mixed to obtain component mixture.Said mixture is successively passed through Micronizer and three-dimensional colloid mill are crushed and are ground, and final emulsion minimum grain size is 0.1-1 μm, are then passed through Spray drying mixes, softwood processed, granulation, after tabletting, tablet is made.
Embodiment 3
It is weighed in the following manner with the parts by weight of each raw material: 30 parts of hickory chick, 15 parts of Hericium erinaceus, 10 parts of Boletus aereus, sandlwood 10 parts of sugared lactobacillus, 5 parts of stachyose, 5 parts of Zinc-rich saccharomyces cerevisiae, are sufficiently mixed to obtain component mixture.Said mixture is successively led to It crosses micronizer and three-dimensional colloid mill is crushed and ground, final emulsion minimum grain size is 0.1-1 μm, then logical Spray drying is crossed, mixes, softwood processed, granulation, after tabletting, tablet be made.
It should be noted that all be substituted for the present composition ingredient technical solution for extracting any combination of raw material It all belongs to the scope of protection of the present invention.
It is used to illustrate the present composition proportion that optimization obtains by following tests example, and generates unexpected collaboration Effect can not only play the role of Antialcoholic liver-protecting, but also can improve intestinal flora composed structure, play guarantor to gastric mucosa Shield effect, has good health-care effect.
1 experimental method
1.1 animal feedings and grouping administration.
This test example is for illustrating that Antialcoholic liver-protecting nourishing the stomach shield intestines composition components of the present invention can not only play Antialcoholic liver-protecting Effect, but also intestinal flora composed structure can be improved, protective effect is played to gastric mucosa.It is male to prepare health C57BL/6J Property mouse 70,18~22 g of weight, 23 ± 1 DEG C of raising temperature, relative humidity 55 ± 5% is randomly divided into 7 groups, and every group 10, Respectively as blank control group, model group, positive group (health promoting liquid being made every effort to overcome, as positive control), example composition group, combination 1(hickory chick, Hericium erinaceus, Boletus aereus), combination 2(hickory chick, Lactobacillus rhamnosus, Zinc-rich saccharomyces cerevisiae), combination 3(rhamnose cream Bacillus, stachyose, Zinc-rich saccharomyces cerevisiae).
Combine 1 sample preparation methods: 20 parts of hickory chick, 15 parts of Hericium erinaceus, 15 parts of Boletus aereus are sufficiently mixed to obtain component Mixture.Said mixture is successively passed through to micronizer and three-dimensional colloid mill is crushed and ground, final emulsion Minimum grain size is 0.1-1 μm, then by spray drying, mix, softwood processed, granulation, after tabletting, tablet be made.
It combines 2 sample preparation methods: weighing 15 parts of hickory chick, 5 parts of Lactobacillus rhamnosus, 3 parts of Zinc-rich saccharomyces cerevisiae, be sufficiently mixed Obtain component mixture.Said mixture is successively passed through to micronizer and three-dimensional colloid mill is crushed and ground, most Whole emulsion minimum grain size is 0.1-1 μm, then by spray drying, mix, softwood processed, granulation, after tabletting, tablet be made.
It combines 3 sample preparation methods: weighing 5 parts of Lactobacillus rhamnosus, 5 parts of stachyose, 3 parts of Zinc-rich saccharomyces cerevisiae, be sufficiently mixed Obtain component mixture.Said mixture is successively passed through to micronizer and three-dimensional colloid mill is crushed and ground, most Whole emulsion minimum grain size is 0.1-1 μm, then by spray drying, mix, softwood processed, granulation, after tabletting, tablet be made.
10 ml/kg physiological saline are given in blank group stomach-filling when every morning 9, remaining is organized equal stomach-filling and gives 13 g/kg 56 Red Star strong, colourless liquor distilled from sorghum is spent, when afternoon 4,10 ml/kg physiological saline are given in blank group and model group stomach-filling；Power is given in positive group stomach-filling Gram health promoting liquid；Corresponding sample (800 mg/ of same volume are given in example composition group, combination 1, combination 2 and combination 3 Kg).
The preparation method of 1.4 samples
Medication terminates, and the fasting of each group mouse can't help plucking after 6 h of water eyeball and take blood, blood stand after 30 min 3500 r/min from 10 min of the heart, takes supernatant, is placed in -20 DEG C of refrigerators and saves for use.After blood sampling, by experimental animal put to death, be rapidly separated mouse liver, Stomach and intestines are saved in -80 DEG C of refrigerators, spare.Some animals stomach is taken, quantitative physiological saline is added and is prepared into 10% liver tissue homogenate Liquid, it is to be measured.
1.5 pathological study
Liver, stomach and intestines are fixed in formalin, are stored at room temperature.Paraffin embedding, slice and HE dyeing are then carried out, and is passed through 400 times of fluorescence inverted microscopes carry out pathological observation and analysis.
The measurement of 1.6 Some Circulating Factors
According to Shanghai source leaf kit specification, glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminease in each group mice serum are measured (AST), the level of the factors such as prostaglandin E2 (PGE2), lipopolysaccharides (LPS).
2 interpretations of result
Protective effect of 2.1 compositions to alcohol-induced hepatic injury
AST and ALT: transaminase is the enzyme of transamination between a kind of catalyst vivo acid and ketone acid, clinically often by AST with Index of the ALT as detection liver function.AST is primarily present in liver cell mitochondria, and ALT is primarily present in liver cell cytoplasm In, work as hepatocellular injury, the two enzyme can enter blood from liver cell, therefore clinically be usually used in measuring hepatocellular injury degree.
It can be obtained by Fig. 1 and Fig. 2 data, embodiment group AST has significant decrease compared to model group with ALT content, with the positive Control group is compared reduces 12.82% and 6.56% respectively.Compared to 1-3 group is combined, embodiment group AST and ALT content is minimum.Such as Shown in Fig. 3, pathological observation the result shows that, control group: liver structure is normal.Model group: fraction necrosis of liver cells is bright It is aobvious.Positive group: cell infiltration (mostly neutrophil leucocyte) and accidental necrosis of liver cells in visible lobuli hepatis.Combine 1-3 group: can The micro milling factor of taking a favourable turn infiltration；Embodiment group: normal.On the one hand its reason can significantly reduce in serum with zinc and edible mushroom Triglycerides and cholesterol level play the role of synergistic correlation to the alleviation of alcoholic fatty liver；Another aspect and sandlwood Both sugared lactobacillus (probiotics) and stachyose compounding are inhibiting hepatic injury and chronic inflammation side caused by oxidative stress and alcohol Face has the function of that collaboration is related.Therefore it may be concluded that the present composition is played by the synergistic effect between each component Preferable hepatoprotective effect.
Protective effect of 2.2 compositions to alcohol-induced gastric injury
Prostaglandin (PGE2) is active material important in gastric mucus, can promote gastric mucus and Bicarbonate secretion, promotes stomach Mucosa cells update, and improve stomach lining blood circulation, stimulate the release of mucosa surface active phospholipid, have enhancing adaptability thin Born of the same parents' protective effect is the gastric mucosal protection factor generally acknowledged at present.
It can be obtained by Fig. 4 data, PGE2 content is obviously improved compared to model group, and PGE2 is improved compared with positive controls 48.75%.Compared to 1-3 group is combined, embodiment group PGE2 content highest.
As shown in figure 5, pathological observation the result shows that, control group: liver structure is normal.Model group: epithelium breakage, Denaturation, necrosis, body of gland mucous modification mucous layer cell infiltration.Positive group: gastric epithelial is damaged, has no other exceptions.Combination 1-3 group: epithelium breakage and slight body of gland mucous modification mucous layer cell infiltration；Embodiment group: gastric epithelial is damaged, has no it He is abnormal.Its reason and edible mushroom and Lactobacillus rhamnosus form synbiotic, guarantee the stabilization of product, can also improve probiotics The functionality of product, so that it is related to play anti-ulcer effect.Therefore it can be concluded that, the present composition passes through the association between each component Same-action plays preferable nourishing the stomach effect.
Protective effect of 2.3 compositions to alcohol-induced damage of intestines
LPS: an important pathogenic factor in alcoholic liver disease, under normal circumstances, due to the defense function of gut barrier, Only micro endotoxin can penetrate into enteron aisle and enter portal venous circulation, when acute or chronic drink, then can cause peripheral blood Level of endotoxin significantly increases.It can be inferred that gut barrier injury degree from raised level.
It can be obtained by Fig. 6, embodiment LPS has significant decrease compared with model group, reduces respectively compared with positive controls 3.76%.Compared to 1-3 group is combined, embodiment group acts on the reduction of LPS content in damage of intestines mice serum best.
As shown in fig. 7, pathological observation the result shows that, control group: villus is clear, epithelium be simple columnar epithelium (column Cell and goblet cell) rule is neat, the visible intestinal glands of submucosa.Model group: each layer structural fuzzy of intestinal wall, epithelium breakage, Gland cell denaturation, the visible damaged and cell infiltration of fuzzy surface.Positive group: more normal.Combine 1-3 group: visible villus The visible damaged and cell infiltration in surface；Embodiment group: more normal.It is the reason is as follows that described: edible mushroom, which contains, has biology Active polysaccharide has improvement result to host intestine flora, can promote the metabolism of profitable strain (such as Bacillus acidi lactici, Bifidobacterium) And proliferation, while having apparent inhibiting effect to pathogen (such as Escherichia coli, clostridium and salmonella).Enteron aisle benefit Raw bacterium generates the exocellular polysaccharide being very beneficial to human body while being largely proliferated using stachyose.Two kinds of prebiotics In conjunction with both improving intestinal environment, protective effect played to enteron aisle normal creepage of gastrointestinal functions and gut barrier, to reach collaboration Effect.Therefore it may be concluded that the present composition plays preferable shield intestines effect by the synergistic effect between each component.

Claims (2)

1. intestines composition is protected in a kind of liver-protecting sobering up nourishing the stomach, it is characterised in that made of the raw material of following parts by weight:
10-30 parts of hickory chick, 10-20 parts of Hericium erinaceus, 10-20 parts of Boletus aereus, 1-10 parts of Lactobacillus rhamnosus, stachyose 1-10 Part, 1-5 parts of Zinc-rich saccharomyces cerevisiae.
2. a kind of preparation method of liver-protecting sobering up nourishing the stomach shield intestines composition as described in claim 1, includes the following steps:
Weigh 10-30 parts of hickory chick, 10-20 parts of Hericium erinaceus, 10-20 parts of Boletus aereus, 1-10 parts of Lactobacillus rhamnosus, stachyose 1-10 parts, 1-5 parts of Zinc-rich saccharomyces cerevisiae, are sufficiently mixed to obtain component mixture；Said mixture is carried out by three-dimensional colloid mill Grinding, minimum grain size are 0.1-1 μm, by spray drying, mix, softwood processed, granulation, after tabletting, tablet are made.
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