CN109890404A - 视觉功能再生剂或视觉功能降低预防剂 - Google Patents

视觉功能再生剂或视觉功能降低预防剂 Download PDF

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Publication number
CN109890404A
CN109890404A CN201780066838.2A CN201780066838A CN109890404A CN 109890404 A CN109890404 A CN 109890404A CN 201780066838 A CN201780066838 A CN 201780066838A CN 109890404 A CN109890404 A CN 109890404A
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Prior art keywords
amino acid
visual performance
ala
val
leu
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Pending
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CN201780066838.2A
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English (en)
Chinese (zh)
Inventor
栗原俊英
坚田侑作
国见洋光
坪田一男
神取秀树
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Keio University
Nagoya Institute of Technology NUC
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Keio University
Nagoya Institute of Technology NUC
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Application filed by Keio University, Nagoya Institute of Technology NUC filed Critical Keio University
Priority to CN202311592678.9A priority Critical patent/CN117695375A/zh
Priority to CN202311592670.2A priority patent/CN117701604A/zh
Priority to CN202311592868.0A priority patent/CN117701605A/zh
Priority to CN202311593358.5A priority patent/CN117701637A/zh
Publication of CN109890404A publication Critical patent/CN109890404A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14171—Demonstrated in vivo effect

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201780066838.2A 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂 Pending CN109890404A (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN202311592678.9A CN117695375A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂
CN202311592670.2A CN117701604A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂
CN202311592868.0A CN117701605A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂
CN202311593358.5A CN117701637A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016-172149 2016-09-02
JP2016172149 2016-09-02
PCT/JP2017/031579 WO2018043707A1 (ja) 2016-09-02 2017-09-01 視覚機能再生剤又は視覚機能低下予防剤

Related Child Applications (4)

Application Number Title Priority Date Filing Date
CN202311592670.2A Division CN117701604A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂
CN202311592678.9A Division CN117695375A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂
CN202311592868.0A Division CN117701605A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂
CN202311593358.5A Division CN117701637A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂

Publications (1)

Publication Number Publication Date
CN109890404A true CN109890404A (zh) 2019-06-14

Family

ID=61301215

Family Applications (5)

Application Number Title Priority Date Filing Date
CN201780066838.2A Pending CN109890404A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂
CN202311592678.9A Pending CN117695375A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂
CN202311592670.2A Pending CN117701604A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂
CN202311592868.0A Pending CN117701605A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂
CN202311593358.5A Pending CN117701637A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂

Family Applications After (4)

Application Number Title Priority Date Filing Date
CN202311592678.9A Pending CN117695375A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂
CN202311592670.2A Pending CN117701604A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂
CN202311592868.0A Pending CN117701605A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂
CN202311593358.5A Pending CN117701637A (zh) 2016-09-02 2017-09-01 视觉功能再生剂或视觉功能降低预防剂

Country Status (6)

Country Link
US (2) US11932679B2 (https=)
EP (2) EP4653537A3 (https=)
JP (5) JP6757024B2 (https=)
CN (5) CN109890404A (https=)
ES (1) ES3059584T3 (https=)
WO (1) WO2018043707A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024199431A1 (zh) * 2023-03-29 2024-10-03 郑州大学第一附属医院 一种嵌合蛋白在治疗视神经变性疾病中的应用
CN118791624A (zh) * 2023-04-11 2024-10-18 苏州星明优健生物技术有限公司 用于治疗视网膜神经退行性疾病的新型gpcr嵌合视蛋白

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4653537A3 (en) 2016-09-02 2026-01-07 Keio University Rhodopsin gene therapy for regenerating visual function or for preventing deterioration in visual function
WO2020148913A1 (ja) * 2019-01-18 2020-07-23 俊英 栗原 網膜疾患の予防および進行抑制、視覚認知行動機能の改善、および視覚機能強化
US11771741B2 (en) 2019-09-13 2023-10-03 Restore Vision Inc. Nucleic acid construct that encodes chimeric rhodopsin
WO2021049634A1 (ja) * 2019-09-13 2021-03-18 株式会社レストアビジョン キメラロドプシンをコードする核酸コンストラクト
CN114729009A (zh) 2019-10-31 2022-07-08 伯尔尼大学 用于眼部基因递送的aav载体变体
CA3195696A1 (en) * 2020-09-17 2022-03-24 Restore Vision Inc. Composition for treating or preventing diseases, disorders, or conditions associated with endoplasmic reticulum stress or all-trans-retinal, protecting retinal thickness, or suppressing reduction in retinal thickness or progress of reduction in retinal thickness

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WO2020148913A1 (ja) 2019-01-18 2020-07-23 俊英 栗原 網膜疾患の予防および進行抑制、視覚認知行動機能の改善、および視覚機能強化
US11771741B2 (en) 2019-09-13 2023-10-03 Restore Vision Inc. Nucleic acid construct that encodes chimeric rhodopsin
WO2021049634A1 (ja) 2019-09-13 2021-03-18 株式会社レストアビジョン キメラロドプシンをコードする核酸コンストラクト

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024199431A1 (zh) * 2023-03-29 2024-10-03 郑州大学第一附属医院 一种嵌合蛋白在治疗视神经变性疾病中的应用
CN118791624A (zh) * 2023-04-11 2024-10-18 苏州星明优健生物技术有限公司 用于治疗视网膜神经退行性疾病的新型gpcr嵌合视蛋白

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Publication number Publication date
EP3508212A4 (en) 2020-05-20
JP7427208B2 (ja) 2024-02-05
WO2018043707A1 (ja) 2018-03-08
EP4653537A2 (en) 2025-11-26
CA3035651A1 (en) 2018-03-08
CN117701637A (zh) 2024-03-15
US11932679B2 (en) 2024-03-19
JP6757024B2 (ja) 2020-09-16
CN117701605A (zh) 2024-03-15
US20190194294A1 (en) 2019-06-27
JP2024026791A (ja) 2024-02-28
EP3508212A1 (en) 2019-07-10
EP3508212B1 (en) 2025-10-22
CN117701604A (zh) 2024-03-15
EP4653537A3 (en) 2026-01-07
JP2020117513A (ja) 2020-08-06
JPWO2018043707A1 (ja) 2019-07-25
JP2022126804A (ja) 2022-08-30
ES3059584T3 (en) 2026-03-23
JP2026063282A (ja) 2026-04-10
CN117695375A (zh) 2024-03-15
US20240247049A1 (en) 2024-07-25

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