CN109867001B

CN109867001B - Reagent device for detecting liver tumor marker enzyme in serum

Info

Publication number: CN109867001B
Application number: CN201910283565.8A
Authority: CN
Inventors: 刘辉; 孟凡瑞; 李美芳
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-04-10
Filing date: 2019-04-10
Publication date: 2020-10-16
Anticipated expiration: 2039-04-10
Also published as: CN109867001A

Abstract

The invention discloses a reagent device for detecting liver tumor marker enzyme in serum, which comprises an insulation box and two moving plates, wherein the top of the insulation box is fixedly connected with two symmetrical side plates, the side surface of the moving plate close to the bottom is provided with a through hole and is connected with positioning rods in a sliding way through the through hole, the opposite ends of the two positioning rods are fixedly connected with the two sides of the insulation box, the surface of one end of the positioning rod close to the insulation box is sleeved with a pressure spring, and the two ends of the pressure spring are fixedly connected with the opposite sides of the moving plate and the insulation. According to the invention, through the matching use of the structures, the problems that in the actual use process, the traditional kit is difficult to realize heat preservation operation on a detection reagent, the reagent is easy to inactivate or reduce the activity, and meanwhile, the reagent taken out of the kit partially precipitates after being kept still for a long time, and needs to be shaken up when in use, so that the labor amount of doctors is increased. Bringing inconvenience to the use.

Description

Reagent device for detecting liver tumor marker enzyme in serum

Technical Field

The invention relates to the technical field of reagent storage, in particular to a reagent device for detecting liver tumor marker enzyme in serum.

Background

The tumor is a cell clone capable of rapidly proliferating, a large amount of enzymes, proteins, hormones and the like are involved in the biochemical reaction process of the tumor cell, not only are the expression quantity changed, but also isozyme spectrum changes and ectopic hormone expression exist, and the changes usually indicate the occurrence and development of the tumor. The detection of the change of the indexes has great clinical application value and is a frequently used reference index for clinicians; the tumor marker is also called tumor marker, and refers to a substance which is characterized in malignant tumor cells, or is produced by malignant tumor cells in an abnormal way, or is produced by the stimulation response of a host to the tumor, and can reflect the occurrence and development of the tumor and monitor the response of the tumor to treatment. Tumor markers are present in tissues, body fluids and excretions of tumor patients and can be detected by immunological, biological and chemical methods; in clinical application, different enzymes are selected for examination according to signs so as to make correct diagnosis; for this people provides a serum liver tumor marker enzyme detection kit which is convenient for various medical institutions to commonly use, for example, a serum liver tumor marker enzyme detection kit disclosed in chinese patent CN202101995U includes a rectangular box body and a box cover which is connected with one side of the rectangular box body in a bending manner, a reagent rack is placed in the box body, 4 circular insertion holes are formed on the reagent rack, and a reagent bottle for respectively accommodating gamma-glutamyl transpeptidase, an alpha-L-fucosidase, a lactate dehydrogenase reagent bottle and an alkaline phosphatase reagent bottle are formed. The utility model discloses a carry out gamma-glutamyl transpeptidase, alpha-L-fucosidase, lactate dehydrogenase, alkaline phosphatase detection and analysis according to using enzyme coupling rate method, be applicable to the diagnosis of liver tumor patient, be convenient for popularize, can be used to full-automatic survey, be applicable to medical treatment and scientific research institutions at all levels and use; however, the traditional kit is difficult to realize heat preservation operation on the detection reagent when in use, the reagent is easy to inactivate or reduce the activity, and meanwhile, the reagent taken out of the kit partially precipitates after being kept still for a long time, and the reagent needs to be shaken up when in use, thereby increasing the labor capacity of doctors. Bringing inconvenience to the use.

Disclosure of Invention

The invention aims to provide a reagent device for detecting liver tumor marker enzyme in serum, which improves the traditional device and solves the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme: the reagent device for detecting the liver tumor marker enzyme in the serum comprises an insulation box and two movable plates, wherein the top of the insulation box is fixedly connected with two symmetrical side plates, the side surface, close to the bottom, of each movable plate is provided with a through hole and is connected with a positioning rod in a sliding mode through the through hole, opposite ends of the two positioning rods are fixedly connected with the two sides of the insulation box, a pressure spring is sleeved on the surface, close to one end of the insulation box, of each positioning rod, and the two ends of the pressure spring are fixedly connected with the opposite sides of the.

The movable plate comprises a movable plate and is characterized in that a first through groove is formed in the front side of the movable plate, a first sliding column is connected to the inner wall of the first through groove in a sliding mode, a rotating arm is fixedly connected to the rear end of the first sliding column, a groove is formed in the front side of a side plate, the surface of the rotating arm is connected with the inner wall of the groove in a rotating mode through a pin shaft, a second through groove is formed in the surface of the rotating arm, a second sliding column is connected to the inner wall of the second through groove in a sliding mode, a connecting rod is fixedly connected to the rear end of the second sliding column, a heat insulation plate is fixedly connected to the bottom of the connecting rod, the side face of.

The top fixedly connected with framework of curb plate, the inner wall fixedly connected with pillar of framework, the top fixedly connected with spheroid of pillar, the spacing rotation in spheroidal surface has the carousel, the upper surface of carousel is equipped with the rubber tape, the surface of test tube and the inner wall sliding connection of rubber tape, the upper surface fixedly connected with motor of framework, the bottom of output shaft runs through the upper surface and the fixedly connected with rocking arm of framework on the motor, be close to the upper surface sliding connection at edge on the bottom of rocking arm and the carousel.

Preferably, the bottom of the heat preservation box is fixedly connected with a base, the base is a circular truncated cone-shaped base, and one end of the base, with a relatively larger caliber, faces downwards.

Preferably, the back sides of the two moving plates are fixedly connected with non-slip pads, and the side faces of the non-slip pads are provided with finger grooves.

Preferably, one end of the positioning rod, which is far away from the heat preservation box, is fixedly connected with a baffle, and the side surface of the baffle can be movably connected with the side surface of the movable plate.

Preferably, the number of the through holes on the heat insulation plate is not less than five, and the through holes are uniformly distributed on the heat insulation plate.

Preferably, the upper surface of the rotating disc is provided with a sliding chute, and the inner wall of the sliding chute is in sliding connection with the bottom of the rotating arm.

Preferably, the bottom of the rotating arm is an arc-shaped surface, and the arc-shaped surface on the rotating arm is in sliding connection with the inner wall of the sliding groove.

Compared with the prior art, the invention has the following beneficial effects:

firstly, the constant temperature of the detection reagent is continuously kept through the heat insulation box, so that the detection reagent can keep a high-activity state; the moving plate plays a role in transmission; the stability of the movable plate in the left-right movement process is ensured through the limitation of the positioning rod; when the two moving plates are pressed, after the elasticity of the pressure spring is overcome, the two moving plates move oppositely; after the opposite pressing of the moving plates is released, the two moving plates are enabled to carry out the opposite movement under the action of the elastic force of the pressure spring; the through grooves have the functions of limiting and guiding; the sliding columns are used for transmission together; when the test tube lifting device is used, when the two moving plates move in opposite directions, the sliding column I moves downwards in the through groove I, so that the rotating arm rotates in the groove, one end, far away from the moving plates, of the rotating arm is tilted, the heat insulation plate is moved upwards through transmission of the connecting rod, the test tube is driven to ascend together, and the test tube is conveniently taken away from the heat insulation plate; in the same way, when the two moving plates move away from each other, the heat insulation plate can descend and is clamped with the inner wall of the heat insulation box, so that sealing heat insulation is realized;

the lower surface of the turntable is provided with an arc surface groove matched with the sphere, the arc surface groove is used for clamping the turntable and the sphere, and the turntable can freely rotate on the sphere; the test tube is fixed on the upper surface of the turntable through the rubber belt and freely rotates along with the turntable, so that the reagent in the test tube is uniformly shaken; the rotating arm is driven to rotate by the motor, and the bottom of the rotating arm slides on the upper surface of the rotating disc, so that the rotating disc rotates by taking a ball on the pillar as a rotating center;

the invention solves the problems that the traditional kit is difficult to realize heat preservation operation on a detection reagent in the use process in the actual use process, the reagent is easy to inactivate or reduce the activity, and the reagent taken out from the kit partially precipitates after being kept still for a long time and needs to be shaken up in use, thereby increasing the labor capacity of doctors. Bringing inconvenience to the use.

Drawings

FIG. 1 is a front cross-sectional view of the structure of the present invention;

fig. 2 is a top view of the chute of the present invention.

In the figure: 1-insulation box, 2-side plate, 3-movable plate, 4-positioning rod, 5-pressure spring, 6-through groove I, 7-sliding column I, 8-rotating arm, 9-groove, 10-through groove II, 11-sliding column II, 12-connecting rod, 13-heat insulation plate, 14-test tube, 15-frame, 16-support, 17-rotating disc, 18-rubber belt, 19-motor, 20-rotating arm, 21-base, 22-anti-skid pad, 23-baffle and 24-sliding groove.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1 to 2, the present invention provides a technical solution: a liver tumor marker enzyme detection reagent device in serum comprises an insulation can 1 and two moving plates 3, wherein the insulation can 1 has the effect of continuously keeping constant temperature for detecting a reagent, so that the test reagent can keep a high-activity state, intermittent heat supply is realized in the insulation can 1 mainly through an electric heating wire after a power supply is switched on, meanwhile, tinfoil paper is pasted in the insulation can and used for enhancing the insulation effect, the moving plates 3 play a role in transmission, the bottom of the insulation can 1 is fixedly connected with a base 21, the base 21 is a circular table-shaped base, one end with a relatively larger caliber on the base 21 faces downwards, and through the arrangement of the base 21, the stability of the device when the whole device is used is improved, and the device is not easy to shake; the arrangement of the round table-shaped base, and the end with relatively larger caliber on the base 21 faces downwards, the contact area with the supporting surface is increased, the integral stability of the device is further improved, the back sides of the two moving plates 3 are fixedly connected with the anti-slip pads 22, the side surfaces of the anti-slip pads 22 are provided with finger grooves, when the two moving plates 3 are oppositely extruded, the anti-slip effect is further improved through the arrangement of the anti-slip pads 22, the anti-slip effect is further improved when the two moving plates are pressed, the top of the heat preservation box 1 is fixedly connected with the two symmetrical side plates 2, the side surface of the moving plate 3 close to the bottom is provided with a through hole and is connected with a positioning rod 4 through the through hole in a sliding way, the stability when the moving plates 3 move left and right is ensured through the limitation of the positioning rod 4, the end of the positioning rod 4 far away from the heat preservation box, through the arrangement of the baffle plate 23, the situation that after the pressing of the pressure spring 5 is relieved, the elastic force of the pressure spring 5 is suddenly released, so that the moving plate 3 excessively moves and is separated from the contact with the positioning rods 4, the opposite ends of the two positioning rods 4 are fixedly connected with the two sides of the heat insulation box 1, the surface of one end, close to the heat insulation box 1, of each positioning rod 4 is sleeved with the pressure spring 5, and when the pressing is carried out, after the elastic force of the pressure spring 5 is overcome, the opposite movement of the two moving plates 3 is; after the opposite pressing of the moving plates 3 is released, the two moving plates 3 are subjected to the opposite movement under the action of the elastic force of the pressure spring 5; two ends of the pressure spring 5 are fixedly connected with the opposite sides of the moving plate 3 and the heat preservation box 1.

The front side of the moving plate 3 is provided with a first through groove 6, the first through groove 6 plays a limiting and guiding role, the inner wall of the first through groove 6 is connected with a first sliding column 7 in a sliding manner, the first sliding column 7 plays a transmission role, the rear end of the first sliding column 7 is fixedly connected with a rotating arm 8, the front side of the side plate 2 is provided with a groove 9, the surface of the rotating arm 8 is rotatably connected with the inner wall of the groove 9 through a pin shaft, the surface of the rotating arm 8 is provided with a second through groove 10, the inner wall of the second through groove 10 is connected with a second sliding column 11 in a sliding manner, the rear end of the second sliding column 11 is fixedly connected with a connecting rod 12, the bottom of the connecting rod 12 is fixedly connected with a heat insulation plate 13, when the two moving plates 3 move oppositely, the first sliding column 7 moves downwards in the first through groove 6, the rotating arm 8 rotates in the groove 9, one end of the moving plate, far away from the 3, the test tube 14 is driven to ascend together, so that the test tube is convenient to take away from the heat insulation plate 13, and similarly, when the two moving plates 3 move away from each other, the heat insulation plate 13 can descend and is clamped with the inner wall of the heat insulation box 1, so that sealing and heat insulation are realized; the number of the through holes on the heat insulation plate 13 is not less than five, the through holes are uniformly distributed on the heat insulation plate 13, the test tubes 14 are fixed through the through holes on the heat insulation plate 13, the number of the through holes on the heat insulation plate 13 is not less than five, the heat insulation plate 1 can be used for placing a sufficient number of test tubes and storing a sufficient number of reagents, the side surface of the heat insulation plate 13 is in sliding connection with the inner wall of the heat insulation plate 1, the upper surface of the heat insulation plate 13 is provided with the through holes and is in sliding connection with the test tubes 14 through the through holes, the test tubes 14 are test tubes with sealed;

the top of the side plate 2 is fixedly connected with a frame body 15, the frame body 15 plays a fixing role, the inner wall of the frame body 15 is fixedly connected with a supporting column 16, the top of the supporting column 16 is fixedly connected with a sphere, the surface of the sphere is limited and rotated with a rotary table 17, the lower surface of the rotary table 17 is provided with an arc groove matched with the sphere and clamped with the sphere through the arc groove, the rotary table 17 can freely rotate on the sphere, the upper surface of the rotary table 17 is provided with a sliding groove 24, the inner wall of the sliding groove 24 is slidably connected with the bottom of a rotary arm 20, the stability of rotation of the rotary arm 20 on the rotary table 17 is ensured through the arrangement of the sliding groove 24, the upper surface of the rotary table 17 is provided with a rubber belt 18, a test tube 14 is fixed on the upper surface of the rotary table 17 through; the surface of test tube 14 and the inner wall sliding connection of rubber tape 18, the last fixed surface of framework 15 is connected with motor 19, the bottom of output shaft runs through the upper surface of framework 15 and fixedly connected with rocking arm 20 on motor 19, drive the rotation of rocking arm 20 through motor 19, the bottom of rocking arm 20 slides on the upper surface of carousel 17, make carousel 17 use the spheroid on the pillar 16 to rotate as the center of rotation, the bottom of rocking arm 20 is the arcwall face, and the arcwall face on the rocking arm 20 and the inner wall sliding connection of spout 24, through the setting of rocking arm 20 bottom arcwall face, make the slip of rocking arm 20 in spout 24 more smooth, the bottom of rocking arm 20 and the last upper surface sliding connection who is close to the edge on carousel 17.

The working principle is as follows: when the reagent device for detecting liver tumor marker enzyme in serum is used and pressed, the two moving plates 3 move oppositely after the elasticity of the pressure spring 5 is overcome; after the opposite pressing of the moving plates 3 is released, the two moving plates 3 are subjected to the opposite movement under the action of the elastic force of the pressure spring 5; when the two moving plates 3 move oppositely, the sliding column I7 moves downwards in the through groove I6, so that the rotating arm 8 rotates in the groove 9, one end of the rotating arm 8, far away from the moving plates 3, is tilted, the heat insulation plate 13 moves upwards through transmission of the connecting rod 12, the test tube 14 is driven to ascend together, and the test tube is conveniently taken away from the heat insulation plate 13; when the two moving plates 3 move away from each other, the heat insulation plate 13 can descend and is clamped with the inner wall of the heat insulation box 1, so that sealing heat insulation is realized; the lower surface of the turntable 17 is provided with an arc surface groove matched with the sphere and the turntable 17 can freely rotate on the sphere by completing the clamping of the arc surface groove and the sphere; the test tube 14 is fixed on the upper surface of the turntable 17 through the rubber belt 18 and freely rotates along with the turntable 17, so that the reagent in the test tube 14 is uniformly shaken; the rotating arm 20 is driven by the motor 19 to rotate, the bottom of the rotating arm 20 slides on the upper surface of the rotating disc 17, so that the rotating disc 17 rotates by taking a sphere on the strut 16 as a rotating center; through the cooperation between the above-mentioned structure, solved in the in-service use because traditional kit is difficult to realize the heat preservation operation to detect reagent when using, easily make reagent deactivation or activity reduce, there is partial sediment in the reagent that the kit was taken out after long-time stewing storage simultaneously, still need shake it when using, increased doctor's amount of labour. Bringing inconvenience to the use.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A liver tumor marker enzyme detect reagent device in serum which characterized in that: the heat preservation box comprises a heat preservation box (1) and two movable plates (3), wherein the top of the heat preservation box (1) is fixedly connected with two symmetrical side plates (2), a through hole is formed in the side surface, close to the bottom, of each movable plate (3) and is connected with a positioning rod (4) in a sliding mode through the through hole, the opposite ends of the two positioning rods (4) are fixedly connected with the two sides of the heat preservation box (1), a pressure spring (5) is sleeved on the surface, close to one end of the heat preservation box (1), of each positioning rod (4), and the two ends of each pressure spring (5) are fixedly connected with the opposite sides of;

a first through groove (6) is formed in the front side of the moving plate (3), a first sliding column (7) is connected to the inner wall of the first through groove (6) in a sliding mode, the rear end of the sliding column I (7) is fixedly connected with a rotating arm (8), the front side of the side plate (2) is provided with a groove (9), the surface of the rotating arm (8) is rotationally connected with the inner wall of the groove (9) through a pin shaft, a second through groove (10) is formed in the surface of the rotating arm (8), a second sliding column (11) is connected to the inner wall of the second through groove (10) in a sliding mode, the rear end of the sliding column II (11) is fixedly connected with a connecting rod (12), the bottom of the connecting rod (12) is fixedly connected with a heat insulation plate (13), the side surface of the heat insulation board (13) is connected with the inner wall of the heat insulation box (1) in a sliding way, the upper surface of the heat insulation plate (13) is provided with a through hole and is connected with a test tube (14) in a sliding way through the through hole;

the top fixedly connected with framework (15) of curb plate (2), inner wall fixedly connected with pillar (16) of framework (15), the top fixedly connected with spheroid of pillar (16), the spacing carousel (17) that has rotated in spheroidal surface, the upper surface of carousel (17) is equipped with rubber tape (18), the surface of test tube (14) and the inner wall sliding connection of rubber tape (18), the upper surface fixedly connected with motor (19) of framework (15), the upper surface and the fixedly connected with rocking arm (20) of framework (15) are run through to the bottom of output shaft on motor (19), be close to the upper surface sliding connection at edge on the bottom of rocking arm (20) and carousel (17).

2. The reagent device for detecting liver tumor marker enzyme in serum according to claim 1, wherein: the bottom fixedly connected with base (21) of insulation can (1), base (21) position round platform shape base, and the relatively great one end of bore is down on base (21).

3. The reagent device for detecting liver tumor marker enzyme in serum according to claim 1, wherein: the back sides of the two moving plates (3) are fixedly connected with anti-slip pads (22), and finger grooves are formed in the side faces of the anti-slip pads (22).

4. The reagent device for detecting liver tumor marker enzyme in serum according to claim 1, wherein: one end of the positioning rod (4) far away from the heat preservation box (1) is fixedly connected with a baffle (23), and the side face of the baffle (23) can be movably connected with the side face of the movable plate (3).

5. The reagent device for detecting liver tumor marker enzyme in serum according to claim 1, wherein: the number of the through holes on the heat insulation plate (13) is not less than five, and the through holes are uniformly distributed on the heat insulation plate (13).

6. The reagent device for detecting liver tumor marker enzyme in serum according to claim 1, wherein: the upper surface of the rotary table (17) is provided with a sliding chute (24), and the inner wall of the sliding chute (24) is in sliding connection with the bottom of the rotating arm (20).

7. The reagent device for detecting liver tumor marker enzyme in serum according to claim 1, wherein: the bottom of the rotating arm (20) is an arc-shaped surface, and the arc-shaped surface on the rotating arm (20) is connected with the inner wall of the sliding groove (24) in a sliding manner.