CN201096776Y

CN201096776Y - Biologic chip

Info

Publication number: CN201096776Y
Application number: CNU200720043379XU
Authority: CN
Inventors: 吴堂明; 潘能科; 陆冬雷; 张必达; 江晨亮
Original assignee: JIANGSU SANLIAN BIOENGINEERING CO Ltd
Current assignee: JIANGSU SANLIAN BIOENGINEERING CO Ltd
Priority date: 2007-10-30
Filing date: 2007-10-30
Publication date: 2008-08-06
Anticipated expiration: 2017-10-30

Abstract

The utility model relates to a biochip, aiming at providing a biochip which is low in framing effect, high in biochip and substrate combing amount, slow in fixed sample activity reduction and easy in automation realization. The technical proposal of the utility model is that the biochip comprises a colored-glass substrate and sampling points on the substrate; the root part of the colored-glass substrate is inserted into a long groove of a handle; a gasket clamping part is arranged between the root part of the substrate and the long groove of the handle; the part with the sampling points on the substrate is arranged into a reaction slot with a concave groove and is sealed; the colored-glass substrate can be green, purple or black; the handle is made of polytetrafluoroethylene; the gasket is made rubber and the reaction slot is made of organic glass. The biochip is low in framing effect and easy in automation realization; after assembly of the handle, the chip is inserted into the reaction groove and sealed; therefore, the chip can only contact with limited air; and the deactivation of bioactive substances such as protein is controlled to achieve the purpose of prolonging chip storage time.

Description

A kind of biochip

Technical field

The utility model relates to a kind of biochip.

Background technology

The making of biochip mainly contains two kinds of forms: a kind of is porous polymer membrane substrate form, mainly fix biological sample by physisorption, though biological sample is had higher unit area fixed amount, but cause the background values height easily in the operation, precision is poor, be difficult to realize robotization, problems such as experimental repeatability difference; Second kind is hard substrate form, mainly be with hard substrates such as glass sheet or silicon chips after chemical conversion treatment, direct synthesising probing needle on substrate, perhaps will synthesize good probe, antibody, biological samples such as antigen are selected and are added on the substrate, react by chemical bond, biological sample is fixed on the hard substrate, its advantage is the sample fixation, advantages such as precision is good, but common on the market its shortcoming of glass sheet sheet base is that the frame effect is obvious at present, and precision still fails to satisfy clinical request for utilization, and biological sample and sheet base binding capacity are low, the active shortcomings such as fast, realization robotization difficulty that reduce of fixed sample.

Summary of the invention

Technical problem to be solved in the utility model provides that a kind of frame effect is low, biological sample and sheet base binding capacity height, the active biochip of slowly, easily realizing robotization that reduces of fixed sample.

The purpose of this utility model is achieved through the following technical solutions: a kind of biochip, comprise the sampling point on coloured glass chip and the sheet base, the root of coloured glass sheet base inserts in the elongated slot of one handle, be provided with pad chucking between the root of sheet base and the elongated slot of handle, have the part of sampling point to pack on the sheet base and seal in the reeded reactive tank.

The color of coloured glass sheet base is green, or purple, also can be black; The material of handle is a teflon; The material of pad is a rubber, and the material of reactive tank is an organic glass.

Sampling point is a protein on the glass chip, nucleic acid, and histotomy, polypeptide, the dot matrix spread pattern is a rectangle, rib type, linear pattern.

The beneficial effects of the utility model: owing to adopted green, the glass chip of purple or black has dropped to floor level with background values, the frame effect obviously reduces, the sheet base is loaded onto the extracting that helps the instrument and equipment mechanical arm behind the handle and is moved the realization robotization, insert in the reactive tank chip and sealing after finishing the handle assembling, chip is only contacted with limited air, controlled the inactivation of bioactivators such as albumen to greatest extent, reach the purpose that prolongs the chip resting period.

Description of drawings

Fig. 1 is a front view of the present utility model;

Fig. 2 is that the A-A of Fig. 1 is to view;

Fig. 3 be Fig. 1 vertical view;

Fig. 4 removes vertical view behind the part 6 for Fig. 2.

Embodiment

The utility model is described in further detail below in conjunction with accompanying drawing.

A kind of biochip, comprise the sampling point on coloured glass chip 3 and the sheet base, the root 5 of coloured glass sheet base inserts in the elongated slot 7 of one handle 6, the root 5 of sheet base and 7 of the elongated slots of handle are provided with pad 4 chuckings, there is the part 1 of sampling point to pack in one fluted 8 the reactive tank 2 on the sheet base, with handle 6 and reactive tank 2 wringing fits, the part 1 that sampling point is arranged on the sheet base is sealed in the reactive tank 2.

The color of coloured glass sheet base 3 is green or purple or black, and the material of handle 6 is a teflon, and the material of pad 4 is a rubber, and the material of reactive tank 2 is an organic glass, and the sampling point on the sheet base is protein or nucleic acid or histotomy or polypeptide.

During making, by predetermined dot matrix arrangement mode biological sample is put green, on purple or the black glass sheet base,, after the drying handle is installed on the sheet base, coincide in the reactive tank of then chip being packed into and closely can use through sealing with spotting robot.

Claims

1, a kind of biochip, comprise the sampling point on coloured glass chip (3) and the sheet base, it is characterized in that: the root (5) of described coloured glass sheet base inserts in the elongated slot (7) of one handle (6), be provided with pad (4) chucking between the elongated slot (7) of root of sheet base (5) and handle, the sealing in the reactive tank (2) of fluted (8) of packing into of the part (1) of sampling point is arranged on the sheet base.

2, biochip according to claim 1 is characterized in that: the color of described coloured glass sheet base (3) is for green.

3, biochip according to claim 1 is characterized in that: the color of described coloured glass sheet base (3) is a purple.

4, biochip according to claim 1 is characterized in that: the color of described coloured glass sheet base (3) is a black.

5, biochip according to claim 1 is characterized in that: the material of described handle (6) is a teflon.

6, biochip according to claim 1 is characterized in that: the material of described pad (4) is a rubber.

7, biochip according to claim 1 is characterized in that: the material of described reactive tank (2) is an organic glass.

8, biochip according to claim 1 is characterized in that: the sampling point on described base is protein or nucleic acid or histotomy or polypeptide.