CN109847100A - 一种具有生物活性的骨水泥及其制备方法 - Google Patents
一种具有生物活性的骨水泥及其制备方法 Download PDFInfo
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- CN109847100A CN109847100A CN201910280988.4A CN201910280988A CN109847100A CN 109847100 A CN109847100 A CN 109847100A CN 201910280988 A CN201910280988 A CN 201910280988A CN 109847100 A CN109847100 A CN 109847100A
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- Prior art keywords
- bone cement
- bone
- preparation
- biologically active
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000002639 bone cement Substances 0.000 title claims abstract description 114
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 38
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims abstract description 25
- 239000004926 polymethyl methacrylate Substances 0.000 claims abstract description 25
- 239000002131 composite material Substances 0.000 claims description 34
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
- 239000000243 solution Substances 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 16
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 8
- 238000000465 moulding Methods 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 238000004108 freeze drying Methods 0.000 claims description 5
- 239000011259 mixed solution Substances 0.000 claims description 5
- 239000000178 monomer Substances 0.000 claims description 5
- 230000010355 oscillation Effects 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 102100026735 Coagulation factor VIII Human genes 0.000 claims description 4
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims description 4
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 4
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 claims description 3
- 229910001928 zirconium oxide Inorganic materials 0.000 claims description 3
- 239000000463 material Substances 0.000 abstract description 25
- 239000004615 ingredient Substances 0.000 abstract description 12
- 230000000975 bioactive effect Effects 0.000 abstract description 6
- 238000006116 polymerization reaction Methods 0.000 abstract description 6
- 229940036811 bone meal Drugs 0.000 abstract description 3
- 239000002374 bone meal Substances 0.000 abstract description 3
- 239000003054 catalyst Substances 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 abstract description 2
- 230000000295 complement effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 22
- 230000000694 effects Effects 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 238000005452 bending Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 239000007943 implant Substances 0.000 description 4
- 238000007711 solidification Methods 0.000 description 4
- 230000008023 solidification Effects 0.000 description 4
- 238000004506 ultrasonic cleaning Methods 0.000 description 4
- 230000006835 compression Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 102000007547 Laminin Human genes 0.000 description 2
- 108010085895 Laminin Proteins 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- -1 developer Substances 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 230000004072 osteoblast differentiation Effects 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
检测内容 | 性能指标 | 标准要求 |
抗压强度/MPa | 82 | >70 |
弯曲强度/MPa | 55 | >50 |
弯曲模量/GPa | 3.0 | >1.8 |
温度峰值/℃ | 52 | <90 |
凝固时间/min | 18 | >5 |
显影效果 | 轮廓清晰、位置易辨 | -- |
检测内容 | 性能指标 | 标准要求 |
抗压强度/MPa | 80 | >70 |
弯曲强度/MPa | 53 | >50 |
弯曲模量/GPa | 3.2 | >1.8 |
温度峰值/℃ | 57 | <90 |
凝固时间/min | 12 | >5 |
显影效果 | 轮廓清晰、位置易辨 | -- |
检测内容 | 性能指标 | 标准要求 |
抗压强度/MPa | 72 | >70 |
弯曲强度/MPa | 54 | >50 |
弯曲模量/GPa | 2.1 | >1.8 |
温度峰值/℃ | 56 | <90 |
凝固时间/min | 10 | >5 |
显影效果 | 轮廓清晰、位置易辨 | -- |
Claims (6)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910280988.4A CN109847100B (zh) | 2019-04-09 | 2019-04-09 | 一种具有生物活性的骨水泥及其制备方法 |
PCT/CN2020/074898 WO2020207114A1 (zh) | 2019-04-09 | 2020-02-12 | 一种具有生物活性的骨水泥及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910280988.4A CN109847100B (zh) | 2019-04-09 | 2019-04-09 | 一种具有生物活性的骨水泥及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109847100A true CN109847100A (zh) | 2019-06-07 |
CN109847100B CN109847100B (zh) | 2020-06-16 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910280988.4A Active CN109847100B (zh) | 2019-04-09 | 2019-04-09 | 一种具有生物活性的骨水泥及其制备方法 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN109847100B (zh) |
WO (1) | WO2020207114A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020207114A1 (zh) * | 2019-04-09 | 2020-10-15 | 浙江科惠医疗器械股份有限公司 | 一种具有生物活性的骨水泥及其制备方法 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100160483A1 (en) * | 2008-12-22 | 2010-06-24 | Heraeus Medical Gmbh | Polymethylmethacrylate bone cement composition for controlled hyperthermia treatment |
CN101934097A (zh) * | 2010-08-19 | 2011-01-05 | 马文 | 含锶的羟基磷灰石-pmma可注射型复合骨水泥及其制备方法和应用 |
WO2012018612A2 (en) * | 2010-07-26 | 2012-02-09 | Warsaw Orthopedic, Inc. | Calcium particle-embedded, snap-to-dough, high-viscosity bone cement |
CN106139253A (zh) * | 2016-07-29 | 2016-11-23 | 深圳先进技术研究院 | 可形成复合骨水泥的组合物及由其形成的骨水泥 |
CN106620841A (zh) * | 2016-12-22 | 2017-05-10 | 宁波华科润生物科技有限公司 | 低温可注射丙烯酸树脂骨水泥及其制备方法 |
CN107412852A (zh) * | 2017-07-26 | 2017-12-01 | 山东冠龙医疗用品有限公司 | 骨水泥组合物及其套组 |
CN107617125A (zh) * | 2017-09-08 | 2018-01-23 | 山东冠龙医疗用品有限公司 | 骨水泥组合物套组 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010005442A1 (en) * | 2008-07-11 | 2010-01-14 | Syracuse University | Multi-solution bone cements and methods of making the same |
US9649404B2 (en) * | 2009-03-05 | 2017-05-16 | Teknimed | Bone filling cement |
FR2957805B1 (fr) * | 2010-03-23 | 2012-04-20 | Teknimed | Systeme a deux composants pour ciment osseux |
CN109847100B (zh) * | 2019-04-09 | 2020-06-16 | 浙江科惠医疗器械股份有限公司 | 一种具有生物活性的骨水泥及其制备方法 |
-
2019
- 2019-04-09 CN CN201910280988.4A patent/CN109847100B/zh active Active
-
2020
- 2020-02-12 WO PCT/CN2020/074898 patent/WO2020207114A1/zh active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100160483A1 (en) * | 2008-12-22 | 2010-06-24 | Heraeus Medical Gmbh | Polymethylmethacrylate bone cement composition for controlled hyperthermia treatment |
WO2012018612A2 (en) * | 2010-07-26 | 2012-02-09 | Warsaw Orthopedic, Inc. | Calcium particle-embedded, snap-to-dough, high-viscosity bone cement |
CN101934097A (zh) * | 2010-08-19 | 2011-01-05 | 马文 | 含锶的羟基磷灰石-pmma可注射型复合骨水泥及其制备方法和应用 |
CN106139253A (zh) * | 2016-07-29 | 2016-11-23 | 深圳先进技术研究院 | 可形成复合骨水泥的组合物及由其形成的骨水泥 |
CN106620841A (zh) * | 2016-12-22 | 2017-05-10 | 宁波华科润生物科技有限公司 | 低温可注射丙烯酸树脂骨水泥及其制备方法 |
CN107412852A (zh) * | 2017-07-26 | 2017-12-01 | 山东冠龙医疗用品有限公司 | 骨水泥组合物及其套组 |
CN107617125A (zh) * | 2017-09-08 | 2018-01-23 | 山东冠龙医疗用品有限公司 | 骨水泥组合物套组 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020207114A1 (zh) * | 2019-04-09 | 2020-10-15 | 浙江科惠医疗器械股份有限公司 | 一种具有生物活性的骨水泥及其制备方法 |
Also Published As
Publication number | Publication date |
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CN109847100B (zh) | 2020-06-16 |
WO2020207114A1 (zh) | 2020-10-15 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A bioactive bone cement and its preparation method Effective date of registration: 20221205 Granted publication date: 20200616 Pledgee: Industrial and Commercial Bank of China Limited Jinhua Branch Pledgor: CANWELL MEDICAL Co.,Ltd. Registration number: Y2022330003493 |
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Date of cancellation: 20231205 Granted publication date: 20200616 Pledgee: Industrial and Commercial Bank of China Limited Jinhua Branch Pledgor: CANWELL MEDICAL Co.,Ltd. Registration number: Y2022330003493 |
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Denomination of invention: A bioactive bone cement and its preparation method Granted publication date: 20200616 Pledgee: Industrial and Commercial Bank of China Limited Jinhua Branch Pledgor: CANWELL MEDICAL Co.,Ltd. Registration number: Y2024980000673 |
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