CN109846977A - It is a kind of prevent and treat slight type hepatic encephalopathy Chinese medicine compound prescription composition and preparation method - Google Patents
It is a kind of prevent and treat slight type hepatic encephalopathy Chinese medicine compound prescription composition and preparation method Download PDFInfo
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Abstract
The invention belongs to drug manufacture fields, more particularly to a kind of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy and preparation method, mainly use a kind of main component of milk thistle, Rhizoma Chuanxiong, Asian puccoon, the rhizoma bolbostemmae, rhizoma acori graminei, mantis egg-case, phoenix-tail fern, membranaceous marshmarigold herb, pennywort, toad grass, Ardisia pusilla, Astilbe chinensis, clover, Indian beech, Fordia cauliflora, Sweet Broomwort Herb as Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy, the profitable strain in balance intestinal；Exclude harmful toxins；Accelerate the recovery of physical function, make the slight faster rehabilitation of type hepatic encephalopathy, and medical fluid is heated in whole city during the preparation process, enable ingredient in drug at analyzing, and eddy flow is carried out to medical fluid, the medical fluid of reflux is utilized again, accelerates the output of medical fluid, reduces the waste of medical fluid during the filtration process；Save the cost.
Description
[technical field]
The invention belongs to drug manufacture fields, and in particular to it is a kind of prevent and treat slight type hepatic encephalopathy Chinese medicine compound prescription composition and
Preparation method.
[background technique]
Slight type hepatic encephalopathy (minimal hepatic encephalopathy, MHE) is previously referred to as recessive or sub-
Clinical type hepatic encephalopathy refers to without obvious clinical manifestation and biochemistry exception, is only capable of with fine intelligent test and (or) electro physiology
The hepatic encephalopathy .MHE that detection can just make diagnosis is cirrhosis common complication, and foreign countries have been reported that display liver cirrhosis patient MHE
Disease incidence be 30%-84%, the domestic disease incidence for once carrying out intelligence tests discovery MHE to 409 liver cirrhosis patients reached
51.3%.MHE conditions of patients concealment is strong, and there are obstacle, operational capacity and stress abilities to lower for nervous functional defects, especially right
In being engaged in high altitude operation or mechanical driver, exists and unexpected hidden danger easily occurs.Therefore it early diagnoses and treatment MHE is with important
Meaning, and paid attention to extensively by domestic and foreign scholars.The cause of disease and pathogenesis of MHE is still not very clear at present, there is no one so far
Kind treatment method or drug have the curative effect of affirmative to all patients.In recent years, some scholars have carried out using Chinese medicine compound prescription group
At the clinical research for carrying out treatment MHE, but curative effect is not obvious, it is therefore desirable to which developing directly can effectively eradicate slight type liver property
Encephalopathy and without any toxicity and side effects Chinese medicine compound prescription composition.
[summary of the invention]
In view of problem above, the present invention provides a kind of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy and preparation sides
Method, the Chinese medicine compound prescription composition that this is a kind of to prevent and treat slight type hepatic encephalopathy are made of plurality of Chinese, effectively eradicate slight type liver property
Encephalopathy and without any toxicity and side effects.
The technical problems to be solved by the invention are implemented with the following technical solutions:
It is a kind of prevent and treat slight type hepatic encephalopathy Chinese medicine compound prescription composition be mainly made of following parts by weight material: 22-30 parts
Milk thistle, 11-23 part Rhizoma Chuanxiong, 14-16 portions of Asian puccoons, the 5-10 parts of rhizoma bolbostemmaes, 5-11 parts of rhizoma acori gramineis, 4-8 parts of mantis egg-cases, 6-12 portions of phoenix
Tail grass, 10-16 parts of membranaceous marshmarigold herbs, 5-12 parts of pennyworts, 10-15 parts of toad grass, 3-13 parts of Ardisia pusillas, 7-15 parts of Astilbe chinensis, 5-15
Part clover, 4-12 parts of Indian beech, 22-29 parts of Fordia caulifloras, 16-23 parts of Sweet Broomwort Herbs.
Preferably, a kind of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy is mainly made of following parts by weight material:
22 portions of milk thistles, 11 parts of Rhizoma Chuanxiongs, 14 portions of Asian puccoons, 5 parts of rhizoma bolbostemmaes, 5 parts of rhizoma acori gramineis, 4 parts of mantis egg-cases, 6 portions of phoenix-tail ferns, 10 parts of horseshoes
Grass, 5 parts of pennyworts, 10 parts of toad grass, 3 parts of Ardisia pusillas, 7 parts of Astilbe chinensis, 5 portions of clovers, 4 parts of Indian beech, 22 parts of Fordia caulifloras, 16
Part Sweet Broomwort Herb.
Preferably, a kind of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy is mainly made of following parts by weight material:
26 portions of milk thistles, 19 parts of Rhizoma Chuanxiongs, 15 portions of Asian puccoons, 8 parts of rhizoma bolbostemmaes, 6 parts of rhizoma acori gramineis, 6 parts of mantis egg-cases, 8 portions of phoenix-tail ferns, 12 parts of horseshoes
Grass, 8 parts of pennyworts, 13 parts of toad grass, 7 parts of Ardisia pusillas, 11 parts of Astilbe chinensis, 9 portions of clovers, 8 parts of Indian beech, 24 parts of Fordia caulifloras,
19 parts of Sweet Broomwort Herbs.
Preferably, a kind of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy is mainly made of following material: 30 parts of water
Fly Ji, 23 parts of Rhizoma Chuanxiongs, 16 portions of Asian puccoons, 10 parts of rhizoma bolbostemmaes, 11 parts of rhizoma acori gramineis, 8 parts of mantis egg-cases, 12 portions of phoenix-tail ferns, 16 parts of membranaceous marshmarigold herbs,
12 parts of pennyworts, 15 parts of toad grass, 13 parts of Ardisia pusillas, 15 parts of Astilbe chinensis, 15 portions of clovers, 12 parts of Indian beech, 29 parts of Fordia caulifloras,
23 parts of Sweet Broomwort Herbs.
A kind of production method of Chinese medicine compound prescription composition that preventing and treating slight type hepatic encephalopathy, comprising the following steps:
1) by milk thistle, Rhizoma Chuanxiong, Asian puccoon, the rhizoma bolbostemmae, rhizoma acori graminei, mantis egg-case, phoenix-tail fern, membranaceous marshmarigold herb, pennywort, toad
Grass, Ardisia pusilla, Astilbe chinensis, clover, Indian beech, Fordia cauliflora, Sweet Broomwort Herb crush to obtain mixed-powder, and mixed-powder is put into medicine
In agent equipment；
Medicament equipment includes: tank body, motor, the first rocker arm, the second rocker arm, fixed block, motion bar, water inlet pipe, charging
Pipe, pressing plate, plate hole, delivery pump, delivery pipe, return pipe, cyclone, discharge nozzle, heater strip；
Tank body is sealing hollow structure；Motion bar both ends are flexibly connected with tank body upper and lower ends；First one end and electricity
The motor shaft of machine is fixedly connected；Second one end is flexibly connected with fixed block, and the other end is flexibly connected with the first rocker arm；Gu
Determine block to be fixedly connected with motion bar；Water inlet pipe and feed pipe connect with tank body and are connected to tank interior；Motion bar is installed on
Tank interior is simultaneously fixedly connected with motion bar, and motion bar is provided with several plate holes；Delivery pipe connect the other end and rotation with tank body
Flow connection at the top of device；Return pipe one end connect the other end with tank body and connect with cyclone bottom；Delivery pipe and return pipe are and tank
Internal portion's connection；Delivery pump is installed in delivery pipe；It is connected to and is partially housed in inside cyclone inside discharge nozzle and cyclone；
Discharge nozzle is contained in the part inside cyclone and is provided with heater strip；Heater strip is looped around outside discharge nozzle；Pressing plate is located at water inlet
Between pipe and feed pipe；Pressing plate is located at below water inlet pipe；
Mixed-powder is put into the tank body of medicament equipment from feed pipe, 130-140 DEG C of water is passed through toward water inlet pipe；Starting electricity
Machine；Motor rotation drives the first rocker arm to move in a circle；The rotation of first rocker arm pulls the second rocker motion；Realize the second rocker arm band
Dynamic motion bar moves up and down relative to tank body；Motion bar band dynamic pressure plate moves up and down in tank body, constantly to the intracorporal mixing of tank
Powder is rolled；Water is flowed to below pressing plate from plate hole and is mixed with mixed-powder；
2) starting motor carries out after rolling 50-70 minutes the mixed-powder in step 1), and starting delivery pump will be in tank body
The mixing liquid in portion is squeezed into cyclone；Mixing liquid is entered in cyclone along a tangential direction by delivery pipe, due to by eddy flow
The limitation of wall, mixing liquid do top-down rotary motion；Impurity particle in mixing liquid is acted on by centrifugal force, to
The movement of cyclone bottom, then tank body is flowed by return pipe and is mixed with mixed-powder, it is continuous using heater strip during eddy flow
Mixing liquid is heated, prevents mixing liquid cooling, the mixing liquid and mixed powder for flowing back into tank body are recombined, mentioned
High preparation efficiency；Mixing liquid after impurity separation is overflowed from discharge nozzle, after the liquid coolant seal overflowed from discharge nozzle, is obtained
To the Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy.
Further, the diameter of several plate holes is 2-3cm.
Further, pressing plate is circular plate structure.
Further, cyclone cone angle is 160-175 °.
Further, the diameter of cyclone is 55-60mm.
Further, mixing liquid is entered the pressure that cyclone uses by delivery pipe along a tangential direction and is by delivery pump
0.15-0.25MPa。
Milk thistle, Chinese medicine name.Nature and flavor: it is bitter, it is cool.Clearing heat and promoting diuresis；Soothing liver-gallbladder.With hepatoprotective effect, reducing blood lipid and anti-dynamic
Arteries and veins atherosclerosis plaque forming, the effect to cardiovascular system, the protective effect to cerebral ischemia, platelet aggregation-against.
Rhizoma Chuanxiong can increase renal blood flow, and can diuresis.Rhizoma Chuanxiong can inhibit DNA to synthesize, and prompt can inhibit protein and antibody
It generates.Rhizoma Chuanxiong plays the role of certain antivitamin E deficiency diseases, it is avoided that causing trophism encephalopathy because of vitamin E deficiency.It can
Reduce H2O2And O2Caused peroxidatic reaction of lipid plays the role of oh resistant and malonaldehyde (MDA) haemolysis.It can obviously reduce complement
Haemolysis inhibits the combination of complement component 3 b (C36) and erythrocyte membrane.Rhizoma Chuanxiong has inhibiting effect to liver fibrosis.
Asian puccoon can also inhibit staphylococcus aureus, Bacterium prodigiosum to having inhibiting effect in capital section 68-1 virus test tube.It is purple
The tincture of grass has inhibiting effect to pyogenic baeceria, Escherichia coli.And the recovery of hepar damnification can be accelerated.
Rhizoma bolbostemmae master contains triterpenoid saponins, such as Bolbostemma paniculatum glucoside A, second, third, fourth；Still contain Coumarins, Asian puccoon cyanogen
The ingredients such as glycosides.Can be clearing heat and detoxicating, mass dissipating and swelling eliminating；Has the function of antiviral and antitumor.
Sweet Broomwort Herb herb (aerial part) herb contains alkaloid 1.6%, dulciol and anti-diabetic ingredient amellin.Root
Containing mannitol about 1%, and containing tannin etc..Root skin contains hexacosyl alcohol, β-sitosterol, D-mannitol.To beta-oxybutyria, albuminuria, acid
The patient of mass formed by blood stasis, symptom can also have mitigation.And excessively high serium inorganic phosphorus is made to decrease, hypercholesterolemia is also mitigated.
Indian beech complete stool can be used as medicine.Development is relatively more in terms of Indian beech composition Study, is separated to from Indian beech
Chemical component mainly have flavones, flavanone, chalcone, dihydrochalcone, triterpene, alkaloid and amino acid etc., modern medicine
Reason is research shows that Indian beech has antibacterial, anti-inflammatory, analgesia, antiviral, antiulcer and the bioactivity such as antitumor.
Fordia cauliflora root, the leaf Fordia cauliflora that can be used as medicine are pungent, flat, sweet in flavor slightly sour, nontoxic, and there is scattered and swollen, analgesic to allay excitement, moisten
Lung resolving sputum and other effects.For diseases such as body post-equalization, pathogen invasion is kept out.
By adopting the above-described technical solution, the invention has the following advantages: mainly using milk thistle, Rhizoma Chuanxiong, purple
Grass, the rhizoma bolbostemmae, rhizoma acori graminei, mantis egg-case, phoenix-tail fern, membranaceous marshmarigold herb, pennywort, toad grass, Ardisia pusilla, Astilbe chinensis, clover, water are yellow
The main component for the Chinese medicine compound prescription composition that skin, Fordia cauliflora, Sweet Broomwort Herb prevent and treat slight type hepatic encephalopathy as a kind of, in balance intestinal
Profitable strain；Exclude harmful toxins；The recovery for accelerating physical function, makes the slight faster rehabilitation of type hepatic encephalopathy.And
And medical fluid is heated in whole city during the preparation process, enables ingredient in drug at analyzing, and carry out eddy flow to medical fluid,
The medical fluid of reflux is utilized again, accelerates the output of medical fluid, reduces the waste of medical fluid during the filtration process；Save the cost.
[Detailed description of the invention]
Fig. 1 is the structural schematic diagram of medicament of the present invention equipment.
Main element symbol description
| Tank body 1 | Motor 11 | First rocker arm 12 |
| Second rocker arm 13 | Fixed block 14 | Motion bar 15 |
| Water inlet pipe 16 | Feed pipe 17 | Pressing plate 18 |
| Plate hole 19 | Delivery pump 20 | Delivery pipe 21 |
| Return pipe 22 | Cyclone 23 | Discharge nozzle 24 |
| Heater strip 25 |
[specific embodiment]
The following examples can help those skilled in the art that the present invention is more fully understood, but cannot be with any
Mode limits the present invention.
Embodiment 1
It is a kind of prevent and treat slight type hepatic encephalopathy Chinese medicine compound prescription composition be mainly made of following parts by weight material: 22 parts of powder-refining with waters
Ji, 11 parts of Rhizoma Chuanxiongs, 14 portions of Asian puccoons, 5 parts of rhizoma bolbostemmaes, 5 parts of rhizoma acori gramineis, 4 parts of mantis egg-cases, 6 portions of phoenix-tail ferns, 10 parts of membranaceous marshmarigold herbs, 5 parts of days
Coriandrum, 10 parts of toad grass, 3 parts of Ardisia pusillas, 7 parts of Astilbe chinensis, 5 portions of clovers, 4 parts of Indian beech, 22 parts of Fordia caulifloras, 16 portions of rock sugar
Grass.
A kind of production method of Chinese medicine compound prescription composition that preventing and treating slight type hepatic encephalopathy, comprising the following steps:
1) by milk thistle, Rhizoma Chuanxiong, Asian puccoon, the rhizoma bolbostemmae, rhizoma acori graminei, mantis egg-case, phoenix-tail fern, membranaceous marshmarigold herb, pennywort, toad
Grass, Ardisia pusilla, Astilbe chinensis, clover, Indian beech, Fordia cauliflora, Sweet Broomwort Herb crush to obtain mixed-powder, and mixed-powder is put into medicine
In agent equipment；
Medicament equipment includes: tank body 1, motor 11, the first rocker arm 12, the second rocker arm 13, fixed block 14, motion bar 15,
Water inlet pipe 16, feed pipe 17, pressing plate 18, plate hole 19, delivery pump 20, delivery pipe 21, return pipe 22, cyclone 23, discharge nozzle
24, heater strip 25；
Tank body 1 is sealing hollow structure；15 both ends of motion bar are flexibly connected with 1 upper and lower ends of tank body；First rocker arm 12 1
End is fixedly connected with the motor shaft of motor 11；Second rocker arm, 13 one end is flexibly connected with fixed block 14, and the other end shakes with first
Arm 12 is flexibly connected；Fixed block 14 is fixedly connected with motion bar 15；Water inlet pipe 16 and feed pipe 17 are connect with tank body 1 and and tank
It is connected to inside body 1；Pressing plate 18 is installed on 1 inside of tank body and is fixedly connected with motion bar 15, and pressing plate 18 is provided with several plate holes
19；The diameter of several plate holes 19 is 2-3cm in the present embodiment；Delivery pipe 21 connect the other end and cyclone 23 with tank body 1
Top connection；22 one end of return pipe connect the other end with tank body 1 and connect with 23 bottom of cyclone；Delivery pipe 21 and return pipe 22 are equal
It is connected to inside tank body 1；Delivery pump 20 is installed in delivery pipe 21；Simultaneously partial receipt is connected to inside discharge nozzle 24 and cyclone 23
Inside cyclone 23；The part that discharge nozzle 24 is contained in inside cyclone 23 is provided with heater strip 25；Heater strip 25 is looped around
Outside discharge nozzle 24；Pressing plate 18 is between water inlet pipe 16 and feed pipe 17；Pressing plate 18 is located at 16 lower section of water inlet pipe；In this implementation
In example, pressing plate 18 is circular plate structure；
Mixed-powder is put into the tank body 1 of medicament equipment from feed pipe 17,140 DEG C of water is passed through toward water inlet pipe 16；Starting
Motor 11；The rotation of motor 11 drives the first rocker arm 12 to move in a circle；The rotation of first rocker arm 12 pulls the movement of the second rocker arm 13；It is real
Existing second rocker arm 13 drives motion bar 15 to move up and down relative to tank body 1；Motion bar 15 is transported in tank body up and down with dynamic pressure plate 18
It is dynamic, constantly the mixed-powder in tank body 1 is rolled；Water flows to 18 lower section of pressing plate from plate hole 19 and mixes with mixed-powder；
2) starting motor 11 carries out after rolling 50 minutes the mixed-powder in step 1), starts delivery pump 20 for tank body 1
Internal mixing liquid is squeezed into cyclone 23；Mixing liquid is entered in cyclone 23 along a tangential direction by delivery pipe 21, at this
It is 0.15- that mixing liquid is entered the pressure that cyclone 23 uses by delivery pipe 21 by delivery pump 20 along a tangential direction in embodiment
0.25MPa；23 cone angle of cyclone is 160-175 °；The diameter of cyclone 23 is 55-60mm；Facilitate solid-liquid point in mixing liquid
From；Due to being limited by 23 wall of cyclone, mixing liquid does top-down rotary motion；Impurity particle in mixing liquid
It is acted on by centrifugal force, is moved to 23 bottom of cyclone, then tank body 1 is flowed by return pipe 22 and is mixed with mixed-powder, in eddy flow
During constantly mixing liquid is heated using heater strip 25, in the present embodiment, 25 heating temperature of heater strip is
135-145℃；Prevent mixing liquid cooling, the mixing liquid and mixed powder for flowing back into tank body 1 recombine, and improve preparation effect
Rate；Mixing liquid after impurity separation is overflowed from discharge nozzle 24, by after the liquid coolant seal that discharge nozzle 24 overflows, is prevented
Control the Chinese medicine compound prescription composition of slight type hepatic encephalopathy.
Embodiment 2
It is a kind of prevent and treat slight type hepatic encephalopathy Chinese medicine compound prescription composition be mainly made of following parts by weight material: 26 parts of powder-refining with waters
Ji, 19 parts of Rhizoma Chuanxiongs, 15 portions of Asian puccoons, 8 parts of rhizoma bolbostemmaes, 6 parts of rhizoma acori gramineis, 6 parts of mantis egg-cases, 8 portions of phoenix-tail ferns, 12 parts of membranaceous marshmarigold herbs, 8 parts of days
Coriandrum, 13 parts of toad grass, 7 parts of Ardisia pusillas, 11 parts of Astilbe chinensis, 9 portions of clovers, 8 parts of Indian beech, 24 parts of Fordia caulifloras, 19 portions of rock sugar
Grass.
A kind of production method of Chinese medicine compound prescription composition that preventing and treating slight type hepatic encephalopathy, comprising the following steps:
1) by milk thistle, Rhizoma Chuanxiong, Asian puccoon, the rhizoma bolbostemmae, rhizoma acori graminei, mantis egg-case, phoenix-tail fern, membranaceous marshmarigold herb, pennywort, toad
Grass, Ardisia pusilla, Astilbe chinensis, clover, Indian beech, Fordia cauliflora, Sweet Broomwort Herb crush to obtain mixed-powder, and mixed-powder is put into medicine
In agent equipment；
Medicament equipment includes: tank body 1, motor 11, the first rocker arm 12, the second rocker arm 13, fixed block 14, motion bar 15,
Water inlet pipe 16, feed pipe 17, pressing plate 18, plate hole 19, delivery pump 20, delivery pipe 21, return pipe 22, cyclone 23, discharge nozzle
24, heater strip 25；
Tank body 1 is sealing hollow structure；15 both ends of motion bar are flexibly connected with 1 upper and lower ends of tank body；First rocker arm 12 1
End is fixedly connected with the motor shaft of motor 11；Second rocker arm, 13 one end is flexibly connected with fixed block 14, and the other end shakes with first
Arm 12 is flexibly connected；Fixed block 14 is fixedly connected with motion bar 15；Water inlet pipe 16 and feed pipe 17 are connect with tank body 1 and and tank
It is connected to inside body 1；Pressing plate 18 is installed on 1 inside of tank body and is fixedly connected with motion bar 15, and pressing plate 18 is provided with several plate holes
19；Delivery pipe 21 connect at the top of the other end and cyclone 23 with tank body 1 and connects；22 one end of return pipe connect the other end with tank body 1
It is connect with 23 bottom of cyclone；Delivery pipe 21 and return pipe 22 are connected to inside tank body 1；Delivery pump 20 is installed on delivery pipe 21
On；It is connected to and is partially housed in inside cyclone 23 inside discharge nozzle 24 and cyclone 23；Discharge nozzle 24 is contained in cyclone 23
Internal part is provided with heater strip 25；Heater strip 25 is looped around outside discharge nozzle 24；Pressing plate 18 is located at water inlet pipe 16 and charging
Between pipe 17；Pressing plate 18 is located at 16 lower section of water inlet pipe；
Mixed-powder is put into the tank body 1 of medicament equipment from feed pipe 17,135 DEG C of water is passed through toward water inlet pipe 16；Starting
Motor 11；The rotation of motor 11 drives the first rocker arm 12 to move in a circle；The rotation of first rocker arm 12 pulls the movement of the second rocker arm 13；It is real
Existing second rocker arm 13 drives motion bar 15 to move up and down relative to tank body 1；Motion bar 15 is transported in tank body up and down with dynamic pressure plate 18
It is dynamic, constantly the mixed-powder in tank body 1 is rolled；Water flows to 18 lower section of pressing plate from plate hole 19 and mixes with mixed-powder；
2) starting motor 11 carries out after rolling 59 minutes the mixed-powder in step 1), starts delivery pump 20 for tank body 1
Internal mixing liquid is squeezed into cyclone 23；Mixing liquid is entered in cyclone 23 along a tangential direction by delivery pipe 21, due to
It is limited by 23 wall of cyclone, mixing liquid does top-down rotary motion；Impurity particle in mixing liquid by from
Mental power function is moved to 23 bottom of cyclone, then is flowed into tank body 1 by return pipe 22 and mixed with mixed-powder, in the process of eddy flow
It is middle constantly mixing liquid to be heated using heater strip 25, prevent mixing liquid cooling, flow back into the mixing liquid of tank body 1 with
Mixed powder recombines, and improves preparation efficiency；Mixing liquid after impurity separation is overflowed from discharge nozzle 24, will be from discharge nozzle 24
After the liquid coolant seal of spilling, the Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy is obtained.
Embodiment 3
It is a kind of prevent and treat slight type hepatic encephalopathy Chinese medicine compound prescription composition be mainly made of following parts by weight material: 30 parts of powder-refining with waters
Ji, 23 parts of Rhizoma Chuanxiongs, 16 portions of Asian puccoons, 10 parts of rhizoma bolbostemmaes, 11 parts of rhizoma acori gramineis, 8 parts of mantis egg-cases, 12 portions of phoenix-tail ferns, 16 parts of membranaceous marshmarigold herbs, 12
Part pennywort, 15 parts of toad grass, 13 parts of Ardisia pusillas, 15 parts of Astilbe chinensis, 15 portions of clovers, 12 parts of Indian beech, 29 parts of Fordia caulifloras, 23
Part Sweet Broomwort Herb.
A kind of production method of Chinese medicine compound prescription composition that preventing and treating slight type hepatic encephalopathy, comprising the following steps:
1) by milk thistle, Rhizoma Chuanxiong, Asian puccoon, the rhizoma bolbostemmae, rhizoma acori graminei, mantis egg-case, phoenix-tail fern, membranaceous marshmarigold herb, pennywort, toad
Grass, Ardisia pusilla, Astilbe chinensis, clover, Indian beech, Fordia cauliflora, Sweet Broomwort Herb crush to obtain mixed-powder, and mixed-powder is put into medicine
In agent equipment；
Medicament equipment includes: tank body 1, motor 11, the first rocker arm 12, the second rocker arm 13, fixed block 14, motion bar 15,
Water inlet pipe 16, feed pipe 17, pressing plate 18, plate hole 19, delivery pump 20, delivery pipe 21, return pipe 22, cyclone 23, discharge nozzle
24, heater strip 25；
Tank body 1 is sealing hollow structure；15 both ends of motion bar are flexibly connected with 1 upper and lower ends of tank body；First rocker arm 12 1
End is fixedly connected with the motor shaft of motor 11；Second rocker arm, 13 one end is flexibly connected with fixed block 14, and the other end shakes with first
Arm 12 is flexibly connected；Fixed block 14 is fixedly connected with motion bar 15；Water inlet pipe 16 and feed pipe 17 are connect with tank body 1 and and tank
It is connected to inside body 1；Pressing plate 18 is installed on 1 inside of tank body and is fixedly connected with motion bar 15, and pressing plate 18 is provided with several plate holes
19；Delivery pipe 21 connect at the top of the other end and cyclone 23 with tank body 1 and connects；22 one end of return pipe connect the other end with tank body 1
It is connect with 23 bottom of cyclone；Delivery pipe 21 and return pipe 22 are connected to inside tank body 1；Delivery pump 20 is installed on delivery pipe 21
On；It is connected to and is partially housed in inside cyclone 23 inside discharge nozzle 24 and cyclone 23；Discharge nozzle 24 is contained in cyclone 23
Internal part is provided with heater strip 25；Heater strip 25 is looped around outside discharge nozzle 24；Pressing plate 18 is located at water inlet pipe 16 and charging
Between pipe 17；Pressing plate 18 is located at 16 lower section of water inlet pipe；
Mixed-powder is put into the tank body 1 of medicament equipment from feed pipe 17,140 DEG C of water is passed through toward water inlet pipe 16；Starting
Motor 11；The rotation of motor 11 drives the first rocker arm 12 to move in a circle；The rotation of first rocker arm 12 pulls the movement of the second rocker arm 13；It is real
Existing second rocker arm 13 drives motion bar 15 to move up and down relative to tank body 1；Motion bar 15 is transported in tank body up and down with dynamic pressure plate 18
It is dynamic, constantly the mixed-powder in tank body 1 is rolled；Water flows to 18 lower section of pressing plate from plate hole 19 and mixes with mixed-powder；
2) starting motor 11 carries out after rolling 70 minutes the mixed-powder in step 1), starts delivery pump 20 for tank body 1
Internal mixing liquid is squeezed into cyclone 23；Mixing liquid is entered in cyclone 23 along a tangential direction by delivery pipe 21, due to
It is limited by 23 wall of cyclone, mixing liquid does top-down rotary motion；Impurity particle in mixing liquid by from
Mental power function is moved to 23 bottom of cyclone, then is flowed into tank body 1 by return pipe 22 and mixed with mixed-powder, in the process of eddy flow
It is middle constantly mixing liquid to be heated using heater strip 25, prevent mixing liquid cooling, flow back into the mixing liquid of tank body 1 with
Mixed powder recombines, and improves preparation efficiency；Mixing liquid after impurity separation is overflowed from discharge nozzle 24, will be from discharge nozzle 24
After the liquid coolant seal of spilling, the Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy is obtained.
Experimental example
Random selection hospital's hepatopathy section is hospitalized and meets patient 280 of the standard of being included in, by successively coding of being hospitalized, random point
For A, B, C, D, E, F, G7 group.A group using a kind of Chinese medicine compound prescription for preventing and treating slight type hepatic encephalopathy made of embodiment 1 form into
Row treatment；B group is treated using a kind of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy made of embodiment 2；C group is adopted
Made of embodiment 3 it is a kind of prevent and treat slight type hepatic encephalopathy Chinese medicine compound prescription composition treated；D group is using in embodiment 1
Manufactured a kind of slight type of prevention and treatment after removal milk thistle, Rhizoma Chuanxiong, Asian puccoon, the rhizoma bolbostemmae, rhizoma acori graminei, mantis egg-case, phoenix-tail fern, membranaceous marshmarigold herb
The Chinese medicine compound prescription composition of hepatic encephalopathy is treated；E group uses in embodiment 1 and removes pennywort, toad grass, Ardisia pusilla, Astilbe chinensis
A kind of manufactured Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy is treated afterwards；G group using give vitamin B compound and
Traditional Chinese herbal decoction oral medication；7 groups of patients have comparativity in age, gender, the cause of disease, course of disease etc..Remaining six groups are used daily
Medicine 1 time, seven groups of the course for the treatment of is 30 days for a course for the treatment of.Observe the NCT of pretherapy and post-treatment MHE patient, plasma endotoxin, blood ammonia,
The variation of TBIL, ALB.
Observe pretherapy and post-treatment liver function index index variation comparison
Influence of the 1 each group therapeutic scheme of table to slight type hepatic encephalopathy
Seen from table 1, after treating 1 course for the treatment of, the NCT of A, B, C group patient, plasma endotoxin, blood ammonia, TBIL, ALB content
It is decreased obviously, has significant difference compared with other four groups.Prove a kind of Chinese medicine compound prescription group for preventing and treating slight type hepatic encephalopathy of the present invention
At having the function of liver protection, protect liver, nourishing the liver and subtracting " poison " synergy have and significantly resist slight type hepatic encephalopathy effect, can make slight
Type hepatic encephalopathy index is obviously improved.And a kind of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy has rapid-action, safety
Property it is high, technical operation is simple, medicament sources are simple, applied widely the advantages that, be suitable for promoting and applying.And lacks and wherein appointed
One simply or multi-flavor medicine will be greatly reduced therapeutic effect.
Typical case
Mr. Wu, 56 years old.Whole skin mucous membrane is without xanthochromia, and sclera is without xanthochromia.Abdomen splash it is grand, percussion be in tympanitic note, abdomen is soft, nothing
Subcutaneous varicos vein of abdominal wall has no visible peristalsis visible intestinal peristalsis and peristaltic wave.Obvious mass is not touched, and liver costal margin does not touch, 3cm under spleen rib.Gurgling sound is just
Often.Hepatic region tenderness percussion pain is obvious.The area Shuan Shen is without percussion pain.Report result: slight type hepatic encephalopathy；By controlling for course for the treatment of
It treats, patient treats the state of an illness and improves significantly, and repetition measurement mind is clear after 3 months, appetite is good, sleep quality is high, stool and urine is without exception, raw
Change index is normal, and abdominal B-scan ultrasonography is shown no obvious abnormalities.
It is beautiful certain, medical history: there is starting to occur epigastric discomfort without obvious inducement before March and closes, nausea, detests in female, illness in 67 years old
Oil, slight out of strength, poor appetite, abdominal distension, haemocyanin reduce, bilirubin increases, prolonged prothrombin；It is anti-using one kind
Control the Chinese medicine compound prescription composition treatment of slight type hepatic encephalopathy；By the treatment of two courses for the treatment of, patient treats the state of an illness and improves significantly.Through
Hospital's check, appetite increases, liver function is normal, and hepatic region tenderness disappears, and slight type hepatic encephalopathy has disappeared.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, fall within the scope of the claimed invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. a kind of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy, which is characterized in that mainly by following parts by weight material system
At: 22-30 portions of milk thistles, 11-23 parts of Rhizoma Chuanxiongs, 14-16 portions of Asian puccoons, the 5-10 parts of rhizoma bolbostemmaes, 5-11 parts of rhizoma acori gramineis, 4-8 parts of mulberry Piao
Octopus, 6-12 portions of phoenix-tail ferns, 10-16 parts of membranaceous marshmarigold herbs, 5-12 parts of pennyworts, 10-15 parts of toad grass, 3-13 parts of Ardisia pusillas, 7-15 parts
Astilbe chinensis, 5-15 portions of clovers, 4-12 parts of Indian beech, 22-29 parts of Fordia caulifloras, 16-23 parts of Sweet Broomwort Herbs.
2. a kind of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy according to claim 1, which is characterized in that described
It is a kind of prevent and treat slight type hepatic encephalopathy Chinese medicine compound prescription composition include following parts by weight material: 22 portions of milk thistles, 11 parts of Rhizoma Chuanxiongs,
14 portions of Asian puccoons, 5 parts of rhizoma bolbostemmaes, 5 parts of rhizoma acori gramineis, 4 parts of mantis egg-cases, 6 portions of phoenix-tail ferns, 10 parts of membranaceous marshmarigold herbs, 5 parts of pennyworts, 10 parts of toads
Bufonid toad grass, 3 parts of Ardisia pusillas, 7 parts of Astilbe chinensis, 5 portions of clovers, 4 parts of Indian beech, 22 parts of Fordia caulifloras, 16 parts of Sweet Broomwort Herbs.
3. a kind of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy according to claim 1, which is characterized in that described
It is a kind of prevent and treat slight type hepatic encephalopathy Chinese medicine compound prescription composition be mainly made of following parts by weight material: 26 portions of milk thistles, 19 parts
Rhizoma Chuanxiong, 15 portions of Asian puccoons, 8 parts of rhizoma bolbostemmaes, 6 parts of rhizoma acori gramineis, 6 parts of mantis egg-cases, 8 portions of phoenix-tail ferns, 12 parts of membranaceous marshmarigold herbs, 8 parts of pennyworts, 13
Part toad grass, 7 parts of Ardisia pusillas, 11 parts of Astilbe chinensis, 9 portions of clovers, 8 parts of Indian beech, 24 parts of Fordia caulifloras, 19 parts of Sweet Broomwort Herbs.
4. a kind of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy according to claim 1, which is characterized in that described
It is a kind of prevent and treat slight type hepatic encephalopathy Chinese medicine compound prescription composition be mainly made of following material: 30 portions of milk thistles, 23 parts of Rhizoma Chuanxiongs, 16
Part Asian puccoon, 10 parts of rhizoma bolbostemmaes, 11 parts of rhizoma acori gramineis, 8 parts of mantis egg-cases, 12 portions of phoenix-tail ferns, 16 parts of membranaceous marshmarigold herbs, 12 parts of pennyworts, 15 parts
Toad grass, 13 parts of Ardisia pusillas, 15 parts of Astilbe chinensis, 15 portions of clovers, 12 parts of Indian beech, 29 parts of Fordia caulifloras, 23 parts of Sweet Broomwort Herbs.
5. a kind of production method of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy according to claim 1, special
Sign is, comprising the following steps:
1) by milk thistle, Rhizoma Chuanxiong, Asian puccoon, the rhizoma bolbostemmae, rhizoma acori graminei, mantis egg-case, phoenix-tail fern, membranaceous marshmarigold herb, pennywort, toad grass, nine
Section dragon, Astilbe chinensis, clover, Indian beech, Fordia cauliflora, Sweet Broomwort Herb crush to obtain mixed-powder, and mixed-powder is put into medicament and is set
In standby；
Medicament equipment includes: tank body, motor, the first rocker arm, the second rocker arm, fixed block, motion bar, water inlet pipe, feed pipe, pressure
Plate, plate hole, delivery pump, delivery pipe, return pipe, cyclone, discharge nozzle, heater strip；
Tank body is sealing hollow structure；Motion bar both ends are flexibly connected with tank body upper and lower ends；First one end and motor
Motor shaft be fixedly connected；Second one end is flexibly connected with fixed block, and the other end is flexibly connected with the first rocker arm；Fixed block
It is fixedly connected with motion bar；Water inlet pipe and feed pipe connect with tank body and are connected to tank interior；Pressing plate is installed in tank body
Portion is simultaneously fixedly connected with motion bar, and pressing plate is provided with several plate holes；Delivery pipe connect the other end and cyclone apex with tank body
Connection；Return pipe one end connect the other end with tank body and connect with cyclone bottom；Delivery pipe and return pipe connect with tank interior
It is logical；Delivery pump is installed in delivery pipe；It is connected to and is partially housed in inside cyclone inside discharge nozzle and cyclone；Discharge nozzle is received
It is dissolved in the part inside cyclone and is provided with heater strip；Heater strip is looped around outside discharge nozzle；Pressing plate is located at water inlet pipe and charging
Between pipe；Pressing plate is located at below water inlet pipe；
Mixed-powder is put into the tank body of medicament equipment from feed pipe, 130-140 DEG C of water is passed through toward water inlet pipe；Start motor；
Motor rotation drives the first rocker arm to move in a circle；The rotation of first rocker arm pulls the second rocker motion；Realize that the second rocker arm drives
Motion bar moves up and down relative to tank body；Motion bar band dynamic pressure plate moves up and down in tank body, constantly to the intracorporal mixed powder of tank
It is rolled at end；Water is flowed to below pressing plate from plate hole and is mixed with mixed-powder；
2) starting motor carries out after rolling 50-70 minutes the mixed-powder in step 1), starts delivery pump for tank interior
Mixing liquid is squeezed into cyclone；Mixing liquid is entered in cyclone along a tangential direction by delivery pipe, due to by eddy flow wall
Limitation, mixing liquid does top-down rotary motion；Impurity particle in mixing liquid is acted on by centrifugal force, Xiang Xuanliu
The movement of device bottom, then tank body is flowed by return pipe and is mixed with mixed-powder, using heater strip constantly to mixed during eddy flow
It closes liquid to be heated, prevents mixing liquid cooling, the mixing liquid and mixed powder for flowing back into tank body recombine, and improve system
Standby efficiency；Mixing liquid after impurity separation is overflowed from discharge nozzle, after the liquid coolant seal overflowed from discharge nozzle, is prevented
Control the Chinese medicine compound prescription composition of slight type hepatic encephalopathy.
6. a kind of production method of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy according to claim 5, special
Sign is that the diameter of several plate holes is 2-3cm.
7. a kind of production method of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy according to claim 5, special
Sign is that pressing plate is circular plate structure.
8. a kind of production method of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy according to claim 5, special
Sign is that cyclone cone angle is 160-175 °.
9. a kind of production method of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy according to claim 5, special
Sign is that the diameter of cyclone is 55-60mm.
10. a kind of production method of Chinese medicine compound prescription composition for preventing and treating slight type hepatic encephalopathy according to claim 5, special
Sign is that it is 0.15-0.25MPa that mixing liquid is entered the pressure that cyclone uses by delivery pump along a tangential direction by delivery pipe.
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| CN111282627A (en) * | 2020-03-26 | 2020-06-16 | 淄博海瑞医疗器械有限公司 | A infiltration device that is used for traditional chinese medicine to pound to pieces in-process |
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| CN101474366A (en) * | 2007-12-31 | 2009-07-08 | 赵合生 | Medicament for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
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