CN109846910A - A kind of compound lentinan particle conducive to chronic hepatitis and tumor in digestive tract rehabilitation - Google Patents
A kind of compound lentinan particle conducive to chronic hepatitis and tumor in digestive tract rehabilitation Download PDFInfo
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- CN109846910A CN109846910A CN201910264342.7A CN201910264342A CN109846910A CN 109846910 A CN109846910 A CN 109846910A CN 201910264342 A CN201910264342 A CN 201910264342A CN 109846910 A CN109846910 A CN 109846910A
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Abstract
The invention discloses a kind of compound lentinan particles conducive to chronic hepatitis and tumor in digestive tract rehabilitation, are made of the bulk pharmaceutical chemicals calculating by weight as follows: 25-35 parts of isomalto-oligosaccharide, 25-35 parts of isomaltoketose, 15-25 parts of Shitake Mushroom P.E, its surplus are starch.Product of the present invention both replenished qi to invigorate the spleen, qi-restoratives righting, and beneficial bacterium can be promoted to grow, inhibit the growth of pathogenic bacteria and spoilage organisms, improve gastrointestinal tract environment, mitigates digestive tract reaction, such as the symptoms such as dry, nausea, diarrhea, mitigate caused toxic side effect after cancer patient is postoperative or radiotherapy chemotherapy；It releives the intense strain of patient, improves the quality of living, enhance the confidence of the patient Zhan Sheng serious illness.
Description
Technical field
The present invention relates to a kind of functional health product compositions, and in particular to lentinan and isomalto-oligosaccharide, different
Composition of maltulose and preparation method thereof.
Background technique
The pathogenesis of tumor in digestive tract is extremely complex, but mainly there are three factors, and one is exactly inherent cause.So-called something lost
Biography factor is exactly this gene for having the inactivation of an oncogene or oncogene or activation to cause to come in patient body
Mutation causes the tumor invasion come.Second reason is exactly eating habit, for example often eats scalding food, wax-made product, bubble
Dish smokes, drinks, and internal carcinogenic factor is caused to increase.Third reason is exactly the influence of environment.Air pollution, water pollution, food
Product additive etc. leads to canceration to gastral influence.Due to seriously affecting for these factors, causes disease of digestive tract and swell
The incidence of tumor is especially high.According to national authority data in 2017, first five cancer of the death rate was mainly lung cancer and digestive system
Cancer, tumor in digestive tract just accounts for 6 in death rate top 10, therefore it provides more treatments or improvement disease of digestive tract
It is necessary with the functional product of tumour.
The be conducive to chronic hepatitis and tumor in digestive tract rehabilitation product now sold currently on the market have very much, most of to also relate to
The effect of possessing can improve the immunity of the human body, replenish qi to invigorate the spleen, qi-restoratives righting.Major product such as Lentinan has QI invigorating strong
Spleen, the effect of qi-restoratives righting.It is mainly used for the treatment of the Radiotherapy chemotherapy of chronic type b metastatic hepatitis and tumor in digestive tract, it is clinical
Using for many years, there is apparent therapeutic effect, but have the following deficiencies: that prescription is single, comprehensive therapeutic effect cannot be played, it can not be multi-party
Position mitigates the toxic side effect of patient；To improving, gastrointestinal tract environment effect is unobvious；The anxious psychology of patient cannot be alleviated；Hard capsule
Agent has a disintegrating procedue, absorbs slower；Dysphagia is not suitable for dysphagia patients and children taking.
Therefore, it is necessary to provide it is a kind of have replenish qi to invigorate the spleen with qi-restoratives centralizing function, can effectively improve gastrointestinal function, subtract
Light digestive tract reaction, such as dry, nausea, diarrhea symptom improve human body to the absorbability of nutritional ingredient and mineral money, alleviate
Biotonus further enhances body immunity, improves the quality of living, and generates synergistic effect, is conducive to chronic type b
The rehabilitation of metastatic hepatitis patient, the compound for reducing caused toxic side effect after alimentary tumor patient is postoperative or radiotherapy chemotherapy are fragrant
Mushroom polyoses grain solves the above problems.
Summary of the invention
Compound lentinan particle provided by the invention, is made of the bulk pharmaceutical chemicals calculating by weight as follows: different malt is low
25-35 parts of glycan, 25-35 parts of isomaltoketose, 15-25 parts of Shitake Mushroom P.E, its surplus are starch.
As a preferred embodiment, the lentinan compound granular is made of the bulk pharmaceutical chemicals calculating by weight as follows:
30 parts of isomalto-oligosaccharide, 30 parts of isomaltoketose, 20 parts of Shitake Mushroom P.E, 20 parts of starch.
Wherein, the Shitake Mushroom P.E production technology specifically: weigh mushroom crushing, sieving；Stirring is added to place, so
After be heated up to 90 degree, refluxing extraction, extracting solution is stood, filter, filtrate decompression, concentration, be cooled to room temperature；Ethyl alcohol, Bian Jia is added
Side stirring, makes to be uniformly mixed, stand overnight, and is centrifuged, the sediment for taking centrifugation to obtain, with ethanol washing 2 times, low temperature drying, and powder
It is broken, obtain Shitake Mushroom P.E.
The preparation method of compound lentinan particle provided by the invention, comprising the following steps: 1) match according to parts by weight
Than weighing raw material, mixes, stir evenly；2) mixture pulverizes and sieves；3) it is dried in 60 DEG C or less to making pellet, it is aqueous
Amount reach 5% hereinafter, packaging to get.
Lentinan extract, which has, to replenish qi to invigorate the spleen, and the effect of qi-restoratives righting for chronic type b metastatic hepatitis and disappears
The Radiotherapy chemotherapy for changing road tumour has exact effect.Scientific research proves that it is thin that mushroom polysaccharide can promote bone-marrow-derived lymphocyte to be converted into slurry
Born of the same parents increase antibody tormation, the enhancing of humoral immunity ability.The function of one mononuclear phagocyte system of monokaryon can be improved, it is thin to reinforce macrophage
The phagocytic activity of born of the same parents and desmacyte.There is expert's research to think lentinan as the specific restorative of lymphocyte and stimulation
Agent is known most strong and best substance in the world at present.Multinomial research has shown that lentinan antitumor action is to pass through increasing
The function of strong immune system is realized.Meanwhile it is fragrant eat in other compositions can reduce liver caused by tumor radiotherapy and chemotherapy
The toxic side effects such as functional lesion and leukopenia.
The mixture that isomalto-oligosaccharide is made of the carbohydrate of different polymerization degree, main ingredient include: isomaltose,
Panose and Isomaltotriose, Isomaltotetraose etc..Do not have to hydrolyze the enzymatic hydrolysis system of isomalto-oligosaccharide in the enteron aisle of human body, because
This, they are not digested absorption, and being directly entered big enteral is preferably that Bifidobacterium is utilized, thus, isomalto-oligosaccharide
It is the proliferation factor of Bifidobacterium, i.e. bifidus factor.It is also referred to as prebiotic again due to beneficial bacterium in its energy high efficiently multiplying enteron aisle
Member.After isomalto-oligosaccharide enters human body intestinal canal, it is that the beneficial bacterium in enteron aisle absorbs decomposition, generates a large amount of short chain fatty acids,
Intestines peristalsis can be stimulated, increases excrement degree of wetting and keeps certain osmotic pressure, and inhibits external source pathogenic bacteria and enteral inherently rotten
The proliferation for losing bacterium reduces the generation of toxic tunning and harmful bacteria；Beneficial bacterium bacterium is helped to pass through phosphatidic acid and intestinal mucosa
Epithelial cell cooperates, and occupies intestinal mucosa surface jointly with other anaerobic bacterias, forms one layer of biomembrane with protective effect
Barrier prevents the invasion of pernicious bacteria, to up to bidirectional modulation constipation and diarrhea, protection liver, the synthesis for promoting vitamin, promote
Into mineral absorptions such as calcium, magnesium, zinc, purification enteron aisle is generated, promotes enterocinesia, releases constipation, promotes immunity of organisms, reducing and put
The effects for the treatment of toxicity caused by chemotherapy.
Isomaltoketose is a kind of natural carbohydrate found in the products such as sugarcane, honey, and it is in recent years that foreign countries, which claim isomalt,
Emerging functionality eats sugar alcohol in the world, is a kind of functional disaccharides.Whole world numerous studies and exploitation, function and is answered
With developed successively always, especially there is specific functionality to human body brain, having and improving mental concentration, anxiety of releiving effect
The effects of fruit and improvement cerebral function.
Compound lentinan particle provided by the invention have replenish qi to invigorate the spleen, qi-restoratives centralizing function, can effectively improve stomach and intestine
Road function mitigates the symptoms such as digestive tract reaction, such as dry, nausea, diarrhea, improves suction of the human body to nutritional ingredient and mineral money
Receipts ability alleviates biotonus, further enhances body immunity, improve the quality of living；And synergistic effect is generated, it is beneficial
In the rehabilitation of chronic type b metastatic hepatitis patient, reduce after alimentary tumor patient is postoperative or radiotherapy chemotherapy that caused poison is secondary to be made
With.
Specific embodiment
Below with reference to specific embodiment, the present invention will be further described.
Embodiment one, the preparation process that lentinan extracts are as follows；
100 grams of mushroom are weighed, is crushed, 50 meshes are crossed；2000 milliliters of pure water are added, stirring is placed 30 minutes, then heated
To 90 degree, refluxing extraction 150 minutes, extracting solution stands 8-12 hours, filters；Filtrate decompression (low temperature concentration) is concentrated into 600-
It 800 milliliters, is cooled to room temperature；90% or more ethyl alcohol is added to alcohol content up to 70%, it is stirring while adding, make to be uniformly mixed, it is quiet
Centrifugation overnight is set, the sediment for taking centrifugation to obtain, with 70% ethanol washing 2 times, (60 DEG C of taking precipitate or less dry for low temperature drying
It is dry), it crushes, obtains lentinan extract.
The lentinan extract product feature of embodiment one is as follows: yellow-gray powder, odorless.It dissolves in water, in second
Almost insoluble in alcohol, extract is calculated by dry product, containing lentinan with DEXTROSE ANHYDROUS (C6H12O6) calculate lentinan contain
Amount is 85.0%.
Lentinan content assaying method is as follows: one product of Example about 0.1g, accurately weighed, sets in iodine flask, adds
Distilled water 20ml, heating make to dissolve, add dilute sulfuric acid 25ml, be heated to reflux 4 hours, let cool, and add instructions phenolphthalein solution 1~2 to drip, add hydrogen
Sodium oxide molybdena test solution to neutrality, precision is added iodine solution (0.1mol/L) 25ml, shakes up, sodium hydroxide test solution 4ml, Bian Jia is added dropwise
Side acutely shakes, close plug, and dark place is placed 10 minutes, adds dilute sulfuric acid 4ml, titrates drop with 0.1mol/L sodium thiosulfate immediately
It is fixed, until adding starch indicator solution 2ml when nearly terminal, continue to be titrated to blue disappearance, and titration results are corrected with blank test,
To obtain the final product.The iodine solution (0.1mol/L) of every 1ml is equivalent to the DEXTROSE ANHYDROUS (C of 9.008mg6H12O6).Above-mentioned result is subtracted
The content of monosaccharide is the content of lentinan.This product is calculated by dry product, containing lentinan with anhydrous grape after sour water solution
Sugar (C6H12O6) calculate, 85.0% must not be lower than.
Embodiment two, lentinan compound granular provided by the invention, includes the following steps, weighs the former material of following weight
Material is prepared: 300 grams of isomalto-oligosaccharide, 300 grams of isomaltoketose taken, 200 grams of Shitake Mushroom P.E is added, is added 200 grams of starch,
It stirs evenly, grinding and sieving, 60 DEG C or less dryings, packs, examine water content 5% hereinafter, to obtain the final product.
Functional health product obtained by the present embodiment, cancer patient is postoperative to take, three times a day, each 10-20 grams,
It is taken after being dissolved with warm water, to the improvement situation of patient's nutrition in postoperative situation and immune indexes and in reduction tumour after 7-10 days
The effect of in terms of patient's toxic and side effects of chemoradiotherapy, is good.
The functional health product changes product forms, and patient is facilitated to take；It by scientific composition, both replenished qi to invigorate the spleen, mended
Empty righting, and beneficial bacterium can be promoted to grow, inhibit the growth of pathogenic bacteria and spoilage organisms, improve gastrointestinal tract environment, mitigates alimentary canal
Reaction, such as dry, nausea, diarrhea symptom mitigate caused toxic side effect after cancer patient is postoperative or radiotherapy chemotherapy；It releives trouble
The intense strain of person, improves the quality of living, and enhances the confidence of the patient Zhan Sheng serious illness.
Claims (3)
1. a kind of compound lentinan particle conducive to chronic hepatitis and tumor in digestive tract rehabilitation, which is characterized in that by pressing as follows
The bulk pharmaceutical chemicals of listed as parts by weight are made: 25-35 parts of isomalto-oligosaccharide, 25-35 parts of isomaltoketose, Shitake Mushroom P.E 15-25
Part, its surplus are starch.
2. compound lentinan particle according to claim 1, which is characterized in that the lentinan compound granular is by such as
Under the bulk pharmaceutical chemicals that calculate by weight be made: 30 parts of isomalto-oligosaccharide, 20 parts of Shitake Mushroom P.E, forms sediment at 30 parts of isomaltoketose
20 parts of powder.
3. the preparation method of compound lentinan particle according to claim 1 to 2, which is characterized in that including following
Step: 1) proportion weighs raw material according to parts by weight, mixes, stirs evenly；2) mixture pulverizes and sieves；3) right in 60 DEG C or less
Make pellet and be dried, until its water content reach 5% hereinafter, packaging to get.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910264342.7A CN109846910A (en) | 2019-04-02 | 2019-04-02 | A kind of compound lentinan particle conducive to chronic hepatitis and tumor in digestive tract rehabilitation |
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| CN201910264342.7A CN109846910A (en) | 2019-04-02 | 2019-04-02 | A kind of compound lentinan particle conducive to chronic hepatitis and tumor in digestive tract rehabilitation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111317815A (en) * | 2020-03-02 | 2020-06-23 | 常德集智生物科技有限公司 | Compound yimai multivitamin granules and preparation method thereof |
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2019
- 2019-04-02 CN CN201910264342.7A patent/CN109846910A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111317815A (en) * | 2020-03-02 | 2020-06-23 | 常德集智生物科技有限公司 | Compound yimai multivitamin granules and preparation method thereof |
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Application publication date: 20190607 |