CN109803982A - Fviii的纯化过程 - Google Patents

Fviii的纯化过程 Download PDF

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Publication number
CN109803982A
CN109803982A CN201780063125.0A CN201780063125A CN109803982A CN 109803982 A CN109803982 A CN 109803982A CN 201780063125 A CN201780063125 A CN 201780063125A CN 109803982 A CN109803982 A CN 109803982A
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CN
China
Prior art keywords
fviii
structure domain
concentration range
domain deletion
deletion form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780063125.0A
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English (en)
Chinese (zh)
Inventor
汤姆·约翰斯顿
伊恩·加纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Profactor Pharma Ltd
Original Assignee
Profactor Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Profactor Pharma Ltd filed Critical Profactor Pharma Ltd
Publication of CN109803982A publication Critical patent/CN109803982A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
CN201780063125.0A 2016-10-11 2017-10-11 Fviii的纯化过程 Pending CN109803982A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1617240.5 2016-10-11
GBGB1617240.5A GB201617240D0 (en) 2016-10-11 2016-10-11 Purification process
PCT/GB2017/053073 WO2018069700A1 (fr) 2016-10-11 2017-10-11 Procédé de purification de fviii

Publications (1)

Publication Number Publication Date
CN109803982A true CN109803982A (zh) 2019-05-24

Family

ID=57610627

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780063125.0A Pending CN109803982A (zh) 2016-10-11 2017-10-11 Fviii的纯化过程

Country Status (6)

Country Link
EP (1) EP3526245A1 (fr)
CN (1) CN109803982A (fr)
EA (1) EA201990926A1 (fr)
GB (1) GB201617240D0 (fr)
WO (1) WO2018069700A1 (fr)
ZA (1) ZA201902183B (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009116A1 (fr) * 1994-09-23 1996-03-28 Massey University Resines chromatographiques et leurs procedes de mise en ×uvre
CN101730707A (zh) * 2007-07-11 2010-06-09 诺沃-诺迪斯克有限公司 使用混合式或多模式树脂来纯化因子ⅷ
CN102066417A (zh) * 2008-06-24 2011-05-18 奥克塔法马股份有限公司 提纯凝固因子ⅷ的方法
CN103539852A (zh) * 2012-07-12 2014-01-29 上海泰龙生物医药科技有限公司 一种从细胞培养液中分离纯化重组人凝血八因子的方法
CN104861060A (zh) * 2014-02-21 2015-08-26 神州细胞工程有限公司 一种纯化凝血因子viii的方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009116A1 (fr) * 1994-09-23 1996-03-28 Massey University Resines chromatographiques et leurs procedes de mise en ×uvre
CN101730707A (zh) * 2007-07-11 2010-06-09 诺沃-诺迪斯克有限公司 使用混合式或多模式树脂来纯化因子ⅷ
CN102066417A (zh) * 2008-06-24 2011-05-18 奥克塔法马股份有限公司 提纯凝固因子ⅷ的方法
CN103539852A (zh) * 2012-07-12 2014-01-29 上海泰龙生物医药科技有限公司 一种从细胞培养液中分离纯化重组人凝血八因子的方法
CN104861060A (zh) * 2014-02-21 2015-08-26 神州细胞工程有限公司 一种纯化凝血因子viii的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
江海燕等: "重组人凝血因子Ⅷ结构改造的研究进展", 《药物生物技术》 *

Also Published As

Publication number Publication date
EA201990926A1 (ru) 2019-09-30
EP3526245A1 (fr) 2019-08-21
GB201617240D0 (en) 2016-11-23
WO2018069700A1 (fr) 2018-04-19
ZA201902183B (en) 2021-02-24

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