CN109793847A - A kind of composite isatis root acupoint injection therapy liquid and preparation method thereof and application method - Google Patents
A kind of composite isatis root acupoint injection therapy liquid and preparation method thereof and application method Download PDFInfo
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Abstract
The invention belongs to pharmaceutical technology fields, it discloses a kind of composite isatis root acupoint injection therapy liquid and preparation method thereof and application method, the injection includes the raw material of following parts by weight: 20-50 parts of isatis root extract, 20-30 parts of kudzu root extract, 10-30 parts of Baical Skullcap root P.E, 10-20 parts of Salvia root P.E, 10-30 parts of Astragalus Root P.E, 10-40 parts of erigeron breviscapus extracts, 5-20 parts of safflower extract, 1-10 parts of yam extract and 1000-3000 parts of injection liquid.Injection of the invention is injected by acupuncture point, can reduce patients' blood, gets through patient's channels and collaterals, promotes the blood circulation of entire patient, improves blood quality, has preventive and therapeutic effect to diabetic neuropathy.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of composite isatis root acupoint injection therapy liquid and preparation method thereof and
Application method.
Background technique
Diabete peripheral herve pathology is one of diabetes major chronic complication, is that incidence is most in diabetic complications
A kind of illness high, appearance is earliest, illness rate are average in 50%-60%.Its physical and mental health for having seriously affected diabetic
And quality of life, it is one of main pathological basis of diabetes.Because its pathogenesis not yet illustrates completely, not yet look for so far
To a kind of ideal treatment method.
Drug injection therapy is that medical fluid etc. is injected into related acupuncture points on the human body or privileged site for guidance with basic theory of tcm,
Method using the synergistic effect of needle thorn and drug to treat disease, is to be produced by a variety for the treatment of factor collective effects in body
Raw therapeutic effect.In recent years, acupoint injection therapy is in treatment diabetic peripheral neuropathy, diabetic retinopathy, sugar
Urine sick occur together cutaneous pruritus and diabetic nephropathy etc. achieve positive effect, and acupoint injection therapy can obviously improve DPN's
Various clinical symptoms have good rush rehabilitative action to the function of limbs of patient.
Summary of the invention
In order to solve the above problems existing in the present technology, it is an object of that present invention to provide a kind of composite isatis root acupuncture point notes
Liquid and preparation method thereof and application method are penetrated, injection is injected by acupuncture point, patients' blood is can reduce, gets through patient
Channels and collaterals promote the blood circulation of entire patient, improve blood quality, have preventive and therapeutic effect to diabetic neuropathy.
The technical scheme adopted by the invention is as follows: a kind of composite isatis root acupoint injection therapy liquid, the original including following parts by weight
Material: 20-50 parts of isatis root extract, 20-30 parts of kudzu root extract, 10-30 parts of Baical Skullcap root P.E, 10-20 parts of Salvia root P.E,
10-30 parts of Astragalus Root P.E, 10-40 parts of erigeron breviscapus extracts, 5-20 parts of safflower extract, 1-10 parts of yam extract and injection
With 1000-3000 parts of liquid.
The injection liquid is pure water or the sodium chloride solution of 0.9wt%.
Another technical solution of the present invention are as follows: a kind of preparation method of composite isatis root acupoint injection therapy liquid, including
Following steps:
Step S1, in injection liquid be added isatis root extract, kudzu root extract, Baical Skullcap root P.E, Salvia root P.E,
Astragalus Root P.E, erigeron breviscapus extracts, safflower extract and yam extract, and stirring and dissolving；
After the completion of dissolution, active carbon is added into injection liquid by step S2, and heating stirring 10-25min is then passed through micro-
Hole membrane filtration obtains clear injection solution；
Step S3, the injection solution that step S2 is obtained is carried out under nitrogen protection environment filling, is then sterilized, is infused
Penetrate liquid.
It is preferred that the isatis root extract is decocted the preparation method comprises the following steps: Radix Isatidis water is decocted 1-3 times
Decoction liquor heating is concentrated to get concentrate, concentrate 50%-70% alcohol reflux is extracted 2-4 times, each 1- by boil liquid
2h, combined extract are simultaneously filtered, are concentrated, are dried in vacuo, are crushed, and obtain isatis root extract.
It is preferred that the Baical Skullcap root P.E the preparation method comprises the following steps: radix scutellariae is measured 30%-70% ethyl alcohol with 5-10 times
Refluxing extraction 2-4 times, 1-2 hours each, combined extract, filtering, concentration, then be filtered with inorganic ceramic membrane, collect filter
Liquid is concentrated again, by being dried in vacuo and crushing, obtains Baical Skullcap root P.E.
It is preferred that the erigeron breviscapus extracts the preparation method comprises the following steps: fleabane flower is smashed, and soaked with 70% ethyl alcohol
12-24h is steeped, is then used ultrasonic wave extraction 2-4 times, each 2-3h, is filtered after combined extract, using being obtained after reduced pressure
Erigeron breviscapus extracts.
It is preferred that in step s 2, the additional amount of the active carbon is the 0.1%-0.3% of injection liquid.
It is preferred that in step s 2, filtering with microporous membrane includes that filtering with microporous membrane, first time micropore are filtered twice
The aperture of film filtering is 0.45um, and the aperture of second of filtering with microporous membrane is 0.22um.
It is preferred that in step s3, the sterilizing is 120 DEG C of pressure sterilizings 20-30 minutes or 130 DEG C of hot pressing are gone out
Bacterium 10-20 minutes.
Another technical solution of the present invention are as follows: a kind of application method of composite isatis root acupoint injection therapy liquid, it is described
Injection is injected by pancreas Yu cave, Pishu Points, point st 36 or SANYINJIAO acupoint.
The invention has the benefit that
The present invention provides a kind of composite isatis root acupoint injection therapy liquid and preparation method thereof and application method, injection to pass through
Acupuncture point is injected, and can reduce patients' blood, gets through patient's channels and collaterals, promotes the blood circulation of entire patient, improves blood matter
Amount has significant therapeutic effect to diabetes, cerebral hemorrhage, cerebral thrombosis, cerebral infarction bolt, Parkinson, gout, hemiplegia etc., to patient
The function of limbs has good rush rehabilitative action, while having preventive and therapeutic effect to diabetic neuropathy.The present invention has both
The double action of needle thorn and drug had not only compensated for external drug and has been not easy to penetrate deficiency cave in, but can by the enhancing of stimulation acupuncture point,
Channels and collaterals are got through, and easy to operate, cheap, Small side effects are curative for effect, are with a wide range of applications.
Specific embodiment
Embodiment 1
A kind of composite isatis root acupoint injection therapy liquid is present embodiments provided, the raw material including following parts by weight: Radix Isatidis mentions
20 parts of object, 20 parts of kudzu root extract, 10 parts of Baical Skullcap root P.E, 10 parts of Salvia root P.E, 10 parts of Astragalus Root P.E, fleabane flower is taken to mention
Take 10 parts of object, 5 parts of safflower extract, 1 part of yam extract and 1000 parts of pure water.
Preferably, Pueraria Flavonid content is 50-95wt%, radix scutellariae in the Baical Skullcap root P.E in the kudzu root extract
Glycosides content is 85%-95wt%, and astragalus polyose content is 30-95wt% in the Astragalus Root P.E, in the yam extract
Chinese yam polysaccharide content is 20-95wt%.
The present invention uses isatis root extract, kudzu root extract, Baical Skullcap root P.E, Salvia root P.E, Astragalus Root P.E, lamp
Small cup flower extract, safflower extract and yam extract obtain injection according to a certain ratio, and injection passes through acupoint injection therapy
Patient is acted on, has the function of clearing heat and promoting diuresis, removing toxic substances except yellow, change dissipates the stagnant stasis of blood, the promoting flow of qi and blood circulation, hundred arteries and veins of dredging.The present invention
By mutual cooperation between each raw material and mutually coordinated, it can reduce patients' blood, get through patient's channels and collaterals, promote entire patient
Blood circulation, improve blood quality, reduce thrombosis.
The present embodiment additionally provides the preparation method of above-mentioned composite isatis root acupoint injection therapy liquid, comprising the following steps:
Isatis root extract, kudzu root extract, Baical Skullcap root P.E, Salvia root P.E, Huang is added in step S1 in pure water
Stilbene extract, erigeron breviscapus extracts, safflower extract and yam extract, and stirring and dissolving.
After the completion of dissolution, active carbon is added into pure water by step S2, and heating stirring 25min then passes through miillpore filter
Filtering, obtains clear injection solution.Wherein, the additional amount of the active carbon is the 0.1% of pure water.Preferably, micropore is filtered
Film filtering includes that filtering with microporous membrane, the aperture of first time filtering with microporous membrane are 0.45um, second of miillpore filter mistake twice
The aperture of filter is 0.22um.
Step S3, the injection solution that step S2 is obtained is carried out under nitrogen protection environment filling, is then sterilized, is infused
Penetrate liquid.Wherein, it is described sterilizing for 120 DEG C pressure sterilizing 30 minutes.
Specifically, the isatis root extract the preparation method comprises the following steps: Radix Isatidis water is decocted obtains decoction liquor 3 times, will
Decoction liquor heating is concentrated to get concentrate, and concentrate 50%-70% alcohol reflux is extracted 4 times, each 1-2h, merges and extracts
Liquid is simultaneously filtered, is concentrated, is dried in vacuo, is crushed, and obtains isatis root extract.The Baical Skullcap root P.E the preparation method comprises the following steps: by yellow
A kind of reed mentioned in ancient books is measured 30%-70% alcohol reflux with 5-10 times and is extracted 4 times, 1-2 hours each, combined extract, filtering, concentration, then uses nothing
Machine ceramic membrane is filtered, and is collected filtrate and is concentrated again, by being dried in vacuo and crushing, obtains Baical Skullcap root P.E.The oil lamp
Flower extract the preparation method comprises the following steps: fleabane flower is smashed, and impregnate 12-24h with 70% ethyl alcohol, then use ultrasonic wave extraction 4 times,
Each 2-3h is filtered after combined extract, using obtaining erigeron breviscapus extracts after reduced pressure.It can be dropped by repeatedly purifying
Low impurity content improves the active constituent content of extract, improves the quality and curative effect of drug.
The present embodiment additionally provides the application method of above-mentioned composite isatis root acupoint injection therapy liquid, and the injection passes through pancreas Yu
Cave, Pishu Points, point st 36 or SANYINJIAO acupoint are injected.Foundation " acupuncture technique operating technology specification " the 6th when use
Point " acupoint injection therapy " carries out, and first extracts medical fluid with disposable sterilized syringe, after carrying cave positioning, disinfection, needle enter pancreas Yu cave,
Pishu Points, point st 36 or SANYINJIAO acupoint, adjustment are brought about the desired sensation, and 1ml medical fluid is injected, out needle and pressing haemostatic.Pass through pancreas Yu cave, spleen
Yu cave, point st 36 or SANYINJIAO acupoint are injected, and can reduce patients' blood, get through patient's channels and collaterals, promote entire patient
Blood circulation, improve blood quality, have to diabetes, cerebral hemorrhage, cerebral thrombosis, cerebral infarction bolt, Parkinson, gout, hemiplegia etc.
Significant therapeutic effect, and acupoint selection is simple and convenient to operate, safety economy, Small side effects.
Embodiment 2
A kind of composite isatis root acupoint injection therapy liquid is present embodiments provided, the raw material including following parts by weight: Radix Isatidis mentions
50 parts of object, 30 parts of kudzu root extract, 30 parts of Baical Skullcap root P.E, 20 parts of Salvia root P.E, 30 parts of Astragalus Root P.E, fleabane flower is taken to mention
Take 40 parts of object, 20 parts of safflower extract, 10 parts of yam extract and 3000 parts of injection liquid, wherein the injection liquid is
The sodium chloride solution of 0.9wt%.
Specifically, Pueraria Flavonid content is 50-95wt%, radix scutellariae in the Baical Skullcap root P.E in the kudzu root extract
Glycosides content is 85%-95wt%, and astragalus polyose content is 30-95wt% in the Astragalus Root P.E, in the yam extract
Chinese yam polysaccharide content is 20-95wt%.
The present embodiment additionally provides the preparation method of above-mentioned composite isatis root acupoint injection therapy liquid, comprising the following steps:
Isatis root extract, kudzu root extract, Baical Skullcap root P.E, Radix Salviae Miltiorrhizae are added in sodium chloride solution and extracts by step S1
Object, Astragalus Root P.E, erigeron breviscapus extracts, safflower extract and yam extract, and stirring and dissolving.
After the completion of dissolution, active carbon is added into sodium chloride solution by step S2, and heating stirring 10-25min is then passed through
Filtering with microporous membrane obtains clear injection solution.Wherein, the additional amount of the active carbon is the 0.3% of sodium chloride solution.It is excellent
Selection of land, filtering with microporous membrane include filtering with microporous membrane twice, and the aperture of first time filtering with microporous membrane is 0.45um, for the second time
The aperture of filtering with microporous membrane is 0.22um.
Step S3, the injection solution that step S2 is obtained is carried out under nitrogen protection environment filling, is then sterilized, is infused
Penetrate liquid.Wherein, the sterilizing is 130 DEG C of pressure sterilizings, 15 minutes
Specifically, the isatis root extract the preparation method comprises the following steps: Radix Isatidis water is decocted obtains decoction liquor 1-3 times,
Decoction liquor heating is concentrated to get concentrate, concentrate 50%-70% alcohol reflux is extracted 3 times, each 1-2h, merging mentions
It takes liquid and filters, is concentrated, is dried in vacuo, crushes, obtain isatis root extract.The Baical Skullcap root P.E the preparation method comprises the following steps: will
Radix scutellariae is measured 30%-70% alcohol reflux with 5-10 times and is extracted 3 times, 1-2 hours each, combined extract, filtering, concentration, then uses
Inorganic ceramic membrane is filtered, and is collected filtrate and is concentrated again, by being dried in vacuo and crushing, obtains Baical Skullcap root P.E.The lamp
Small cup flower extract the preparation method comprises the following steps: fleabane flower is smashed, and 12-24h is impregnated with 70% ethyl alcohol, then with ultrasonic wave extraction 3
Secondary, each 2-3h is filtered after combined extract, using obtaining erigeron breviscapus extracts after reduced pressure.
The present embodiment additionally provides the application method of above-mentioned composite isatis root acupoint injection therapy liquid, and the injection passes through pancreas Yu
Cave, Pishu Points, point st 36 or SANYINJIAO acupoint are injected.Foundation " acupuncture technique operating technology specification " the 6th when use
Point " acupoint injection therapy " carries out, and first extracts medical fluid with disposable sterilized syringe, after carrying cave positioning, disinfection, needle enter pancreas Yu cave,
Pishu Points, point st 36 or SANYINJIAO acupoint, adjustment are brought about the desired sensation, and 1ml medical fluid is injected, out needle and pressing haemostatic.Pass through pancreas Yu cave, spleen
Yu cave, point st 36 or SANYINJIAO acupoint are injected, and can reduce patients' blood, get through patient's channels and collaterals, promote entire patient
Blood circulation, improve blood quality, have to diabetes, cerebral hemorrhage, cerebral thrombosis, cerebral infarction bolt, Parkinson, gout, hemiplegia etc.
Significant therapeutic effect, and acupoint selection is simple and convenient to operate, safety economy, Small side effects.
Embodiment 3
A kind of composite isatis root acupoint injection therapy liquid is present embodiments provided, the raw material including following parts by weight: Radix Isatidis mentions
35 parts of object, 25 parts of kudzu root extract, 20 parts of Baical Skullcap root P.E, 15 parts of Salvia root P.E, 20 parts of Astragalus Root P.E, fleabane flower is taken to mention
Take 25 parts of object, 10 parts of safflower extract, 5 parts of yam extract and 2000 parts of injection liquid.Wherein, the injection liquid is pure
Water.
Preferably, Pueraria Flavonid content is 50-95wt%, radix scutellariae in the Baical Skullcap root P.E in the kudzu root extract
Glycosides content is 85%-95wt%, and astragalus polyose content is 30-95wt% in the Astragalus Root P.E, in the yam extract
Chinese yam polysaccharide content is 20-95wt%.
The present embodiment additionally provides the preparation method of above-mentioned composite isatis root acupoint injection therapy liquid, comprising the following steps:
Step S1, in injection liquid be added isatis root extract, kudzu root extract, Baical Skullcap root P.E, Salvia root P.E,
Astragalus Root P.E, erigeron breviscapus extracts, safflower extract and yam extract, and stirring and dissolving.
After the completion of dissolution, 0.2% active carbon is added into injection liquid by step S2, and heating stirring 10-25min is passed through after
Filtering with microporous membrane is crossed, clear injection solution is obtained.Preferably, filtering with microporous membrane includes filtering with microporous membrane twice, the
The aperture of filtering with microporous membrane is 0.45um, and the aperture of second of filtering with microporous membrane is 0.22um.
Step S3, the injection solution that step S2 is obtained is carried out under nitrogen protection environment filling, is then sterilized, is infused
Penetrate liquid.Wherein, it is described sterilizing for 120 DEG C pressure sterilizing 30 minutes.
Specifically, the isatis root extract the preparation method comprises the following steps: Radix Isatidis water is decocted obtains decoction liquor 1-3 times,
Decoction liquor heating is concentrated to get concentrate, concentrate 50%-70% alcohol reflux is extracted 4 times, each 1-2h, merging mentions
It takes liquid and filters, is concentrated, is dried in vacuo, crushes, obtain isatis root extract.The Baical Skullcap root P.E the preparation method comprises the following steps: will
Radix scutellariae is measured 30%-70% alcohol reflux with 5-10 times and is extracted 2 times, 1-2 hours each, combined extract, filtering, concentration, then uses
Inorganic ceramic membrane is filtered, and is collected filtrate and is concentrated again, by being dried in vacuo and crushing, obtains Baical Skullcap root P.E.The lamp
Small cup flower extract the preparation method comprises the following steps: fleabane flower is smashed, and 12-24h is impregnated with 70% ethyl alcohol, then with ultrasonic wave extraction 3
Secondary, each 2-3h is filtered after combined extract, using obtaining erigeron breviscapus extracts after reduced pressure.
The present embodiment additionally provides the application method of above-mentioned composite isatis root acupoint injection therapy liquid, and the injection passes through pancreas Yu
Cave, Pishu Points, point st 36 or SANYINJIAO acupoint are injected.Foundation " acupuncture technique operating technology specification " the 6th when use
Point " acupoint injection therapy " carries out, and first extracts medical fluid with disposable sterilized syringe, after carrying cave positioning, disinfection, needle enter pancreas Yu cave,
Pishu Points, point st 36 or SANYINJIAO acupoint, adjustment are brought about the desired sensation, and 1ml medical fluid is injected, out needle and pressing haemostatic.Pass through pancreas Yu cave, spleen
Yu cave, point st 36 or SANYINJIAO acupoint are injected, and can reduce patients' blood, get through patient's channels and collaterals, promote entire patient
Blood circulation, improve blood quality, have to diabetes, cerebral hemorrhage, cerebral thrombosis, cerebral infarction bolt, Parkinson, gout, hemiplegia etc.
Significant therapeutic effect, and acupoint selection is simple and convenient to operate, safety economy, Small side effects.
Embodiment 4
A kind of composite isatis root acupoint injection therapy liquid is present embodiments provided, the raw material including following parts by weight: Radix Isatidis mentions
25 parts of object, 20 parts of kudzu root extract, 15 parts of Baical Skullcap root P.E, 15 parts of Salvia root P.E, 20 parts of Astragalus Root P.E, fleabane flower is taken to mention
Take 15 parts of object, 5 parts of safflower extract, 3 parts of yam extract and 1500 parts of injection liquid.Wherein, the injection liquid is
The sodium chloride solution of 0.9wt%.
Preferably, Pueraria Flavonid content is 50-95wt%, radix scutellariae in the Baical Skullcap root P.E in the kudzu root extract
Glycosides content is 85%-95wt%, and astragalus polyose content is 30-95wt% in the Astragalus Root P.E, in the yam extract
Chinese yam polysaccharide content is 20-95wt%.
The present embodiment additionally provides the preparation method of above-mentioned composite isatis root acupoint injection therapy liquid, comprising the following steps:
Step S1, in injection liquid be added isatis root extract, kudzu root extract, Baical Skullcap root P.E, Salvia root P.E,
Astragalus Root P.E, erigeron breviscapus extracts, safflower extract and yam extract, and stirring and dissolving；
After the completion of dissolution, 0.1% active carbon is added into injection liquid by step S2, and heating stirring 10-25min is passed through after
Filtering with microporous membrane is crossed, clear injection solution is obtained.Preferably, filtering with microporous membrane includes filtering with microporous membrane twice, the
The aperture of filtering with microporous membrane is 0.45um, and the aperture of second of filtering with microporous membrane is 0.22um.
Step S3, the injection solution that step S2 is obtained is carried out under nitrogen protection environment filling, is then sterilized, is infused
Penetrate liquid.Wherein, it is described sterilizing for 120 DEG C pressure sterilizing 25 minutes.
Specifically, the isatis root extract the preparation method comprises the following steps: Radix Isatidis water is decocted obtains decoction liquor 1-3 times,
Decoction liquor heating is concentrated to get concentrate, concentrate 50%-70% alcohol reflux is extracted 3 times, each 1-2h, merging mentions
It takes liquid and filters, is concentrated, is dried in vacuo, crushes, obtain isatis root extract.The Baical Skullcap root P.E the preparation method comprises the following steps: will
Radix scutellariae is measured 30%-70% alcohol reflux with 5-10 times and is extracted 3 times, 1-2 hours each, combined extract, filtering, concentration, then uses
Inorganic ceramic membrane is filtered, and is collected filtrate and is concentrated again, by being dried in vacuo and crushing, obtains Baical Skullcap root P.E.The lamp
Small cup flower extract the preparation method comprises the following steps: fleabane flower is smashed, and 12-24h is impregnated with 70% ethyl alcohol, then with ultrasonic wave extraction 4
Secondary, each 2-3h is filtered after combined extract, using obtaining erigeron breviscapus extracts after reduced pressure.
The present embodiment additionally provides the application method of above-mentioned composite isatis root acupoint injection therapy liquid, and the injection passes through pancreas Yu
Cave, Pishu Points, point st 36 or SANYINJIAO acupoint are injected.Foundation " acupuncture technique operating technology specification " the 6th when use
Point " acupoint injection therapy " carries out, and first extracts medical fluid with disposable sterilized syringe, after carrying cave positioning, disinfection, needle enter pancreas Yu cave,
Pishu Points, point st 36 or SANYINJIAO acupoint, adjustment are brought about the desired sensation, and 1ml medical fluid is injected, out needle and pressing haemostatic.Pass through pancreas Yu cave, spleen
Yu cave, point st 36 or SANYINJIAO acupoint are injected, and can reduce patients' blood, get through patient's channels and collaterals, promote entire patient
Blood circulation, improve blood quality, have to diabetes, cerebral hemorrhage, cerebral thrombosis, cerebral infarction bolt, Parkinson, gout, hemiplegia etc.
Significant therapeutic effect, and acupoint selection is simple and convenient to operate, safety economy, Small side effects.
Embodiment 5
A kind of composite isatis root acupoint injection therapy liquid is present embodiments provided, the raw material including following parts by weight: Radix Isatidis mentions
45 parts of object, 30 parts of kudzu root extract, 25 parts of Baical Skullcap root P.E, 20 parts of Salvia root P.E, 25 parts of Astragalus Root P.E, fleabane flower is taken to mention
Take 20 parts of object, 15 parts of safflower extract, 5 parts of yam extract and 3000 parts of injection liquid.Wherein, the injection liquid is pure
Water.
Preferably, Pueraria Flavonid content is 50-95wt%, radix scutellariae in the Baical Skullcap root P.E in the kudzu root extract
Glycosides content is 85%-95wt%, and astragalus polyose content is 30-95wt% in the Astragalus Root P.E, in the yam extract
Chinese yam polysaccharide content is 20-95wt%.
The present embodiment additionally provides the preparation method of above-mentioned composite isatis root acupoint injection therapy liquid, comprising the following steps:
Step S1, in injection liquid be added isatis root extract, kudzu root extract, Baical Skullcap root P.E, Salvia root P.E,
Astragalus Root P.E, erigeron breviscapus extracts, safflower extract and yam extract, and stirring and dissolving；
After the completion of dissolution, 0.3% active carbon is added into injection liquid by step S2, and heating stirring 10-25min is passed through after
Filtering with microporous membrane is crossed, clear injection solution is obtained.Preferably, filtering with microporous membrane includes filtering with microporous membrane twice, the
The aperture of filtering with microporous membrane is 0.45um, and the aperture of second of filtering with microporous membrane is 0.22um.
Step S3, the injection solution that step S2 is obtained is carried out under nitrogen protection environment filling, is then sterilized, is infused
Penetrate liquid.Wherein, it is described sterilizing for 130 DEG C pressure sterilizing 15 minutes.
Specifically, the isatis root extract the preparation method comprises the following steps: Radix Isatidis water is decocted obtains decoction liquor 1-3 times,
Decoction liquor heating is concentrated to get concentrate, concentrate 50%-70% alcohol reflux is extracted 4 times, each 1-2h, merging mentions
It takes liquid and filters, is concentrated, is dried in vacuo, crushes, obtain isatis root extract.The Baical Skullcap root P.E the preparation method comprises the following steps: will
Radix scutellariae is measured 30%-70% alcohol reflux with 5-10 times and is extracted 2 times, 1-2 hours each, combined extract, filtering, concentration, then uses
Inorganic ceramic membrane is filtered, and is collected filtrate and is concentrated again, by being dried in vacuo and crushing, obtains Baical Skullcap root P.E.The lamp
Small cup flower extract the preparation method comprises the following steps: fleabane flower is smashed, and 12-24h is impregnated with 70% ethyl alcohol, then with ultrasonic wave extraction 3
Secondary, each 2-3h is filtered after combined extract, using obtaining erigeron breviscapus extracts after reduced pressure.
The present embodiment additionally provides the application method of above-mentioned composite isatis root acupoint injection therapy liquid, and the injection passes through pancreas Yu
Cave, Pishu Points, point st 36 or SANYINJIAO acupoint are injected.Foundation " acupuncture technique operating technology specification " the 6th when use
Point " acupoint injection therapy " carries out, and first extracts medical fluid with disposable sterilized syringe, after carrying cave positioning, disinfection, needle enter pancreas Yu cave,
Pishu Points, point st 36 or SANYINJIAO acupoint, adjustment are brought about the desired sensation, and 1ml medical fluid is injected, out needle and pressing haemostatic.Pass through pancreas Yu cave, spleen
Yu cave, point st 36 or SANYINJIAO acupoint are injected, and can reduce patients' blood, get through patient's channels and collaterals, promote entire patient
Blood circulation, improve blood quality, have to diabetes, cerebral hemorrhage, cerebral thrombosis, cerebral infarction bolt, Parkinson, gout, hemiplegia etc.
Significant therapeutic effect, and acupoint selection is simple and convenient to operate, safety economy, Small side effects.
Composite isatis root acupoint injection therapy liquid provided by the invention, is injected by acupuncture point, has had both needle thorn and drug
Double action had not only compensated for external drug and has been not easy to penetrate deficiency in cave, but also can have been enhanced by stimulation acupuncture point, get through channels and collaterals, right
Cardiovascular and cerebrovascular disease has good control efficiency, and its is easy to operate, cheap, Small side effects, curative for effect, has wide
General application prospect.
0 grade of diabetes B diabetes 30 are chosen, patient with diabetic feet meets diabetes world clinical guidelines
Diagnostic criteria.Wherein male 15, female 15, the age -65 years old 45 years old, average age 54.3 years old, diabetic duration (3 ± 1.3) year；
Receive diabetes systematic treating, oral hypoglycemic agents or insulin therapy are effective.All patients feet's skins are complete, no opening
Lesion is venation block through Chinese medical discrimination, and it is purplish red or purple dim to show as pedal skin, and limbs send out numbness cool, sharp ache.Phase
It closes the point st 36 that patient numbers in order, and spends each patient and carries out injection composite isatis root acupoint injection therapy liquid, inject 1 daily
It is secondary, 1ml injection is injected every time, and 7 days as a course for the treatment of.
As a result: after the completion of a course for the treatment of, the diabetes of all patients have obtained different degrees of improvement, specific table
Now accelerate for the blood flow velocity of arteria dorsalis pedis, blood flow increases, and foot pain is substantially reduced.It is some after the completion of two courses for the treatment of
The lighter patients feet's skin of diabetes has been gradually recovered, and more serious patients feet's pain has obtained apparent improvement.
After the completion of three courses for the treatment of, the lighter patients feet's function of some diabetes is recovered completely, more serious patients feet
It has been gradually recovered.
Thus illustrate, injection of the invention is conducive to improve pedal blood circulation, alleviates the foot symptom of diabetes
And sign, there is good rush rehabilitative action to the function of limbs of patient, there is preferable prevention and treatment to make diabetic neuropathy
With.The present invention has broken the barrier of traditional technology, brings new hope for domestic diabetic.
The present invention is not limited to above-mentioned optional embodiment, anyone can show that other are each under the inspiration of the present invention
The product of kind form.Above-mentioned specific embodiment should not be understood the limitation of pairs of protection scope of the present invention, protection of the invention
Range should be subject to be defined in claims, and specification can be used for interpreting the claims.
Claims (10)
1. a kind of composite isatis root acupoint injection therapy liquid, which is characterized in that the raw material including following parts by weight: isatis root extract
20-50 parts, 20-30 parts of kudzu root extract, 10-30 parts of Baical Skullcap root P.E, 10-20 parts of Salvia root P.E, Astragalus Root P.E 10-30
Part, 10-40 parts of erigeron breviscapus extracts, 5-20 parts of safflower extract, 1-10 parts of yam extract and injection liquid 1000-3000
Part.
2. composite isatis root acupoint injection therapy liquid according to claim 1, which is characterized in that the injection liquid is pure water
Or the sodium chloride solution of 0.9wt%.
3. a kind of preparation method of composite isatis root acupoint injection therapy liquid described in claim 1, which is characterized in that including following step
It is rapid:
Isatis root extract, kudzu root extract, Baical Skullcap root P.E, Salvia root P.E, Radix Astragali is added in step S1 in injection liquid
Extract, erigeron breviscapus extracts, safflower extract and yam extract, and stirring and dissolving；
After the completion of dissolution, active carbon is added into injection liquid by step S2, and heating stirring 10-25min then passes through micropore filter
Film filtering, obtains clear injection solution；
Step S3, the injection solution that step S2 is obtained is carried out under nitrogen protection environment filling, is then sterilized, is injected
Liquid.
4. the preparation method of composite isatis root acupoint injection therapy liquid according to claim 3, which is characterized in that the Radix Isatidis
Extract obtains decoction liquor the preparation method comprises the following steps: Radix Isatidis water is decocted 1-3 times, and decoction liquor heating is concentrated to get concentration
Liquid, by concentrate with 50%-70% alcohol reflux extract 2-4 time, each 1-2h, combined extract and filter, be concentrated, vacuum do
Dry, crushing, obtains isatis root extract.
5. the preparation method of composite isatis root acupoint injection therapy liquid according to claim 3, which is characterized in that the radix scutellariae mentions
Extracting 2-4 times the preparation method comprises the following steps: radix scutellariae is measured 30%-70% alcohol reflux with 5-10 times for object is taken, it is 1-2 hours each, merge
Extracting solution, filtering, concentration, then be filtered with inorganic ceramic membrane, it collects filtrate and is concentrated again, by being dried in vacuo and crushing,
Obtain Baical Skullcap root P.E.
6. the preparation method of composite isatis root acupoint injection therapy liquid according to claim 3, which is characterized in that the fleabane flower
Extract the preparation method comprises the following steps: fleabane flower is smashed, and impregnate 12-24h with 70% ethyl alcohol, then use ultrasonic wave extraction 2-4 times,
Each 2-3h is filtered after combined extract, using obtaining erigeron breviscapus extracts after reduced pressure.
7. the preparation method of composite isatis root acupoint injection therapy liquid according to claim 3, which is characterized in that in step S2
In, the additional amount of the active carbon is the 0.1%-0.3% of injection liquid.
8. the preparation method of composite isatis root acupoint injection therapy liquid according to claim 3, which is characterized in that in step S2
In, filtering with microporous membrane includes filtering with microporous membrane twice, and the aperture of first time filtering with microporous membrane is 0.45um, and second is micro-
The aperture of hole membrane filtration is 0.22um.
9. the preparation method of composite isatis root acupoint injection therapy liquid according to claim 3, which is characterized in that in step S3
In, the sterilizing for 120 DEG C of pressure sterilizings 20-30 minutes or 130 DEG C pressure sterilizing 10-20 minutes.
10. a kind of application method of composite isatis root acupoint injection therapy liquid described in claim 1, which is characterized in that the injection
Liquid is injected by pancreas Yu cave, Pishu Points, point st 36 or SANYINJIAO acupoint.
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Citations (3)
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|---|---|---|---|---|
| CN1733039A (en) * | 2004-08-13 | 2006-02-15 | 贵阳云岩西创药物科技开发有限公司 | Compound preparation of breviscapinum for treating cardiovascular and cerebrovascular diseases and its preparing process |
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| CN1733039A (en) * | 2004-08-13 | 2006-02-15 | 贵阳云岩西创药物科技开发有限公司 | Compound preparation of breviscapinum for treating cardiovascular and cerebrovascular diseases and its preparing process |
| CN105412291A (en) * | 2015-12-09 | 2016-03-23 | 贵州瑞和制药有限公司龙里药厂 | Application of Shuganning to preparation of medicine for treating diabetic neuropathy and complications |
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Application publication date: 20190524 |