CN109793807A - A kind of substance and preparation method and purposes for preventing and treating parkinsonism - Google Patents
A kind of substance and preparation method and purposes for preventing and treating parkinsonism Download PDFInfo
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- CN109793807A CN109793807A CN201711140844.6A CN201711140844A CN109793807A CN 109793807 A CN109793807 A CN 109793807A CN 201711140844 A CN201711140844 A CN 201711140844A CN 109793807 A CN109793807 A CN 109793807A
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Abstract
The present invention discloses a kind of substance for preventing and treating parkinsonism and preparation method and purposes.Substance of the invention is the fatty contents of seeds of rubber tree, can be applied to drug, health food, in food, treatment and adjuvant treatment for Parkinson's disease patients.The substance is made with the kernel for drying the seeds of rubber tree after decladding by the methods of mechanical presses method, supercritical extraction.Parkinson's disease patients pass through daily to be taken or the edible drug, health food, food for being added to the substance can be obtained good treatment and adjuvant treatment effect.
Description
Technical field
The invention belongs to biomedicine fields, and specifically the present invention relates to one kind is treated for Parkinson's disease patients
With the substance (fatty contents of seeds of rubber tree) and preparation method and purposes of adjuvant treatment.
Background technique
Parkinsonism (Parkinson disease, PD) insidious onset, makes slow progress.Onset symptoms are usually side limb
Body tremble or activity is clumsy, and then involve contralateral limbs.Clinically it is mainly shown as that static tremor, bradykinesia, flesh are strong
Straight and posture gait disorder.People more and more notice the non-motor symptoms such as depression, constipation and sleep disturbance in recent years
It is the common main suit of Parkinson's disease patients, their influences to patients ' life quality are even more than motor symptoms.
Currently, drug therapy is the most important treatment means of parkinsonism.Dopar is still most effective drug,
Though effective in cure, many patients are forced to be discontinued because side effect is big, or because of long term usage, drug effect decrescence, and not can control the state of an illness from
So development.Therefore, disturbances in patients with Parkinson disease needs a kind of without side-effects, and can take for a long time, can alleviate symptom, can also delay
The substance of progression of the disease improves the quality of life of disturbances in patients with Parkinson disease.
Summary of the invention
The substance and preparation method that the purpose of the present invention is to provide a kind of for preventing and treating Parkinson's disease patients and
Purposes.The substance is the fatty contents of seeds of rubber tree, be can be applied in drug, health food and food, for pa gold
The treatment and adjuvant treatment of gloomy disease patient.Parkinson's disease patients pass through daily take or the edible drug for being added to the substance,
The effect that health food or food can be obtained good alleviation symptom, delays progression of the disease.
In order to realize above-mentioned purpose of the invention, the present invention provides the following technical solutions:
Seeds of rubber tree fatty contents, the seeds of rubber tree fatty contents are prepared by any one in following methods:
Mechanical presses method: using virgin rubber tree species as raw material, after drying shelling, kernel is obtained, kernel material is before extrusion
It is heated to 80-100 DEG C, then by static squeeze or dynamic screw extrusion, extrusion liquid is rubber tree
Seed fatty contents；
Extraction method: using virgin rubber tree species as raw material, after drying shelling, obtaining kernel, and kernel is carried out extruding, is granulated
Or it is rolling embryo with leaching container that is after processing, being put into sealing, solvent is added, selected solvent is soybean extracting solvent no.6, boiling
One of 30-90 DEG C of point range of petroleum ether, n-hexane, ether, ethyl acetate, n-butanol, or wherein several mixing
Object is stirred and mixes with solvent to material under the temperature condition and normal pressure lower than solvent boiling point, or carries out ultrasonic wave
Processing, allows material to come into full contact with solvent, staticly settles later, leaches solvent, then in the temperature for being higher than solvent boiling point and very
Under empty condition, solvent is allowed to volatilize, the liquid stayed is seeds of rubber tree fatty contents；
Supercritical extract: using virgin rubber tree species as raw material, after drying shelling, obtaining kernel, and kernel is carried out extruding, is granulated
Or after rolling embryo processing, it is put into the supercritical extract container of sealing pressure resistance, solvents carbon dioxide is added, is being more than solvent critical
Under conditions of temperature and critical pressure, material is stirred and is mixed with solvent, or carry out ultrasonication, allow material and
Solvent comes into full contact with.It staticly settles later, leaches solvent, then at room temperature, reduce pressure, allow solvent to volatilize, leave
The liquid come is seeds of rubber tree fatty contents.
Invention also provides the seeds of rubber tree fatty contents containing therapeutically effective amount and pharmaceutically may be used
The pharmaceutical composition of the carrier of receiving.
And health food, it is made of the seeds of rubber tree fatty contents and health food common carrier.
And food, it is made of the seeds of rubber tree fatty contents and food common carrier.
The present invention also provides the seeds of rubber tree fatty contents for treating application of the parkinsonism in drug.
The application, wherein the seeds of rubber tree fatty contents are as sole active agent.
Present invention further provides the seeds of rubber tree fatty contents to protect for assisting in the treatment of parkinsonism
Application in health food.
And the seeds of rubber tree fatty contents are for assisting in the treatment of application of the parkinsonism in food.
According to the experimental data of parkinsonism animal model, and other experimental datas, Parkinson is directed to existing
Disease patient is treated compared with the drug of adjuvant treatment, the present invention has the advantage that (1) seeds of rubber tree liposoluble substance
There is no toxic side effect, can be used for a long time for disturbances in patients with Parkinson disease, the development of the state of an illness can be delayed；(2) disturbances in patients with Parkinson disease onset is hidden
It attacks, not noticeable, usually delay treatment, however seeds of rubber tree liposoluble substance itself has the effect of prevention to parkinsonism
Fruit can play the role of prevention so can suitably take when not falling ill；(3) warp is clinical experiments have proved that Parkinson's disease patients
Daily by taking or having eaten the drug, health food or the food that add the liposoluble substance and be directly prepared into, can effectively change
It trembles caused by kind parkinsonism, the symptoms such as obstacle of taking action；And the course of disease can be alleviated, improve the sleep disturbance of patient, can obviously change
The quality of life of kind Parkinson's disease patients.
Specific embodiment
Below by the embodiment of the present invention, property content is described further for the essence of the present invention, but is not limited with this
The fixed present invention.
Embodiment 1
This example is the influence probed into substance of the present invention and cause PD model mice to paraquat (Paraquat) (PQ).This example is divided into
4 groups, wherein blank control group stomach-filling distilled water 10ml/kg 1 time a day, 1 times a week intraperitoneal injection of saline 10ml/kg；
Remaining 3 groups are injected intraperitoneally PQ, 10mg/kg, and colchicin of stomach-filling daily 1 times a week, by 4 times of adult dosage, i.e.,
0.2mg/kg, the continuous administration of modeling in 6 weeks；After the completion of modeling, positive controls 1 Madopar of daily stomach-filling is equivalent to human body and pushes away
7.5 times of the amount of recommending are administered by 125mg/kg dosage, be administered continuously to modeling latter week；Object human body recommended amounts of the present invention are
15.0g/ days, adult's 60kg batheroom scale is pressed, being equivalent to daily per kilogram of body weight recommended amounts is 250.0mg.Dosage is
2500.0mg/kg.BW, is equivalent to 10 times of human body recommended amounts, and gastric infusion was administered continuously to modeling latter week.In identical item
It is raised under part, the behaviouristics for observing mouse changes.Turn-club test and autonomic activities test experiments, observation index such as table are carried out respectively
Shown in 1.Specific experimental procedure is as follows.
Reagent, sample and animal
1.1 reagents: paraquat (Paraquat) (PQ), lot number: 090511, Shandong Qiaochang Chemical Co., Ltd's production；Autumn waters -- limid eyes
Celestial alkali, 0.5mg/ piece, lot number: 090207, the production of Xishuangbanna pharmaceutcal corporation, Ltd；Madopar, 250mg/ piece, lot number:
SH0784, the production of Shanghai Co., Ltd, Roche Group；DAB kit, lot number: 09043, purchased from the limited public affairs of Wuhan doctor moral biology
Department；TH antibody 1 is anti-, lot number: 090516, it is purchased from Wuhan doctor moral biology Co., Ltd, remaining reagent is that commercially available analysis is pure；
1.2 test sample preparation methods: mechanical presses method prepares seeds of rubber tree fatty contents, and institute's choosing method is static squeezes
Platen press.Using 100kg virgin rubber tree species as raw material, after drying shelling, kernel 40kg is prepared.Kernel material arrives 80- in heat
100 DEG C, then by static extruding, pressure 50MPa, squeezing out 12kg liquid is substance rubber tree species of the invention
Sub- fatty contents；
1.3 experimental animals: Kunming mouse, SPF grades, 28.0 ± 2.0g, half male and half female, animal credit number are as follows: the Shandong SCXK()
2012-0015。
Experimental method
2.1 modelings and administration: take kunming mice 80, weight: 28.0 ± 2.0g, half male and half female are randomly divided into 4 after adapting to 1 week
Group, is respectively as follows: blank control group, model group, positive controls, dosage group of the present invention, and every group 20, totally 4 groups.Wherein blank pair
According to group stomach-filling distilled water 10ml/kg 1 time a day, intraperitoneal injection of saline 10ml/kg 1 times a week；Remaining 3 groups abdomens 1 times a week
Chamber injects PQ, 10mg/kg, and colchicin of stomach-filling daily, by 4 times of adult dosage, i.e. 0.2mg/kg, continuous 6 weeks
Modeling administration；In addition, positive controls 1 Madopar of daily stomach-filling, is equivalent to 7.5 times of human body recommended amounts, that is, press 125mg/
The administration of kg dosage, was administered continuously to modeling latter week；The dosage that this hair prepares substance is 166.7mg/kg.BW, is equivalent to
10 times of human body recommended amounts, gastric infusion were administered continuously to modeling latter week.It raises under the same conditions, observes the row of mouse
Change to learn；
2.2 index observing
2.2.1 turn-club test normal mouse has climbing ability, this needs grip appropriate in sports coordination, we use
Turn-club test detects the dyskinesia after mouse gives PQ.After stopping administration 1 week, mouse is put in transfer rod tester
On, 6 are put every time, is rotated by 20 turns of speed per minute, and the number to fall down in every mouse 3min is recorded；
2.2.2 autonomic activities measurement stops after giving PQ1 weeks, mouse is put into the active box of autonomic activities tester, every time
6 mouse are measured simultaneously, and 1 mouse in each case is put into mouse adaptation 3min and starts to test again, when computer enters measurement journey
After sequence, activity and the number stood in mouse 10min are automatically recorded by computer.
Experimental result
3.1 behaviouristics variation therapeutic administratp observes the behaviouristics variation of mouse after a week, and every group of 20 mouse are turned respectively
Stick experiment and autonomic activities test, the results are shown in Table 1；
1 mice behavior testing result of table (unit: secondary)
| Group | n | Transfer rod averages out lower number | Horizontal anomalous movement average | Standing activity number | Activity general comment mean |
| Blank control group | 20 | 2 | 8 | 78 | 86 |
| Model group | 20 | 6** | 3.5 | 24.5** | 28** |
| Positive controls | 20 | 5 | 9.5 | 59.5## | 69## |
| Dosage group of the present invention | 20 | 7 | 11.5 | 49.5# | 67.5## |
Note: compared with the control group, there is conspicuousness in *, P < 0.05 to P；There are extremely significant property in *, P < 0.01.P is compared with to model group, #, P
< 0.05 has conspicuousness；There are extremely significant property in ##, P < 0.01
3.2 conclusions: test result shows that the present invention can effectively antagonize the change of Parkinson's mice behavior caused by PQ, can have
Effect improve tremble caused by parkinsonism, the symptoms such as obstacle of taking action.
Embodiment 2
Mechanical presses method prepares seeds of rubber tree fatty contents, and institute's choosing method is static extrusion.With 100kg virgin rubber tree
Seed is raw material, after drying shelling, prepares kernel 40kg.Kernel material arrives 80-100 DEG C in heat, then squeezes by static
Pressure, pressure 50MPa, squeezing out 12kg liquid is substance seeds of rubber tree fatty contents of the invention.
The double born of the same parents' first of disturbances in patients with Parkinson disease and second, female, the age 56 years old, their father suffered from parkinsonism, so having family
Genetic history, onset symptoms be side limbs tremble and activity is clumsy, be accumulated to contralateral limbs later.Elder sister takes Asia after the onset
Liposoluble substance made of flaxseed oil, and younger sister starts to take the fatty contents of seeds of rubber tree made of the present embodiment, clothes
Dosage is 5.0g/ days (in terms of the substance treated for disturbances in patients with Parkinson disease), after taking 2 months, hospital is gone to check, elder sister
Side limbs tremble and activity clumsiness is further aggravated, while with insomnia, and the state of an illness of younger sister remains always steady
Fixed, the cardinal symptom and sign of younger sister disappears substantially, and part work can be taken care of oneself and be participated in life.Illustrate only to take of the invention
Substance seeds of rubber tree fatty contents, can be used to treat the disturbances in patients with Parkinson disease of early stage.
Embodiment 3
Mechanical presses method prepares seeds of rubber tree fatty contents, and institute's choosing method is screw extrusion method.With 100kg virgin rubber tree
Seed is raw material, after drying shelling, prepares kernel 40kg.Kernel material arrives 80-100 DEG C in heat, then squeezes by dynamic spiral
Pressure, screw extrusion time are 45 seconds or so, and squeezing out 15kg liquid is substance seeds of rubber tree fatty contents of the invention.
Disturbances in patients with Parkinson disease third, male, the age 65 years old, patient main suit was that " my limbs send out deadlock and harden, limbs, neck or trunk
Feel there is apparent resistance." fall ill and treated later using the pharmaceutical admixtures of Dopar.After treatment one month,
The dosage of Dopar is kept to original half, and starts to take the fat-soluble portion of seeds of rubber tree made of the present embodiment
Point, dose is 10g/ days (in terms of the substance assisted in the treatment of for disturbances in patients with Parkinson disease), and after one month (the 2 of morbidity treatment
After a month), the state of an illness can remain stable, and cardinal symptom and sign take a favorable turn, but movement still has certain difficulty or slow compared with ordinary person.
Illustrate to eat substance seeds of rubber tree fatty contents of the invention that there is apparent adjuvant treatment effect to disturbances in patients with Parkinson disease.
Embodiment 4
Solvent extraction prepares seeds of rubber tree fatty contents, and extracting selected solvent is No. 6 solvents.With the fresh rubber of 100kg
Gum seed is that raw material prepares kernel 40kg after drying shelling.Then after kernel being carried out expanding treatment, it is put into sealing
Leaching container, the solvent of 2 times of weight is added.Under 55 DEG C of (be lower than solvent boiling point) conditions and normal pressure, to material and solvent into
Row is stirred and is mixed, and material is allowed to come into full contact with solvent.It staticly settles later, leaches solvent, then (be higher than solvent at 120 DEG C
Boiling temperature) under 100Pa vacuum condition, allow solvent to volatilize, staying 18kg liquid is substance rubber of the invention
The sub- fatty contents of tree species.
Disturbances in patients with Parkinson disease fourth, male, the age 60 years old, patient main suit are as follows: " I has found that the right hand (or left hand) of oneself must not recently
Strength, it is agile in the past to be not so good as, and writes unlike so beautiful in the past, and the harvest for beating egg thinks that the right hand is not obedient, not as good as another
Hand is flexible.Think that right leg hair is heavy when on foot, it appears that it is a little dilatory, it sleeps also not so good, it is usually more irritated." adopt after the onset
It is treated with the pharmaceutical admixtures of dopamine agonist.After treatment one month, dose is kept to original half, and starts to eat this reality
The fatty contents of seeds of rubber tree made of example are applied, amount is 20g/ days (to be assisted in the treatment of for disturbances in patients with Parkinson disease
Substance meter), after four months (behind 3 months of morbidity treatment), conditions of patients can remain stable, and cardinal symptom and sign take a favorable turn.
Illustrate to eat substance seeds of rubber tree fatty contents of the invention that there is good adjuvant treatment effect to Parkinson's disease patients.
Embodiment 5
Supercritical extraction prepares seeds of rubber tree fatty contents, and selected solvent is carbon dioxide.With 100kg virgin rubber
Tree species is that raw material prepares kernel 40kg after drying shelling.After kernel is carried out granulation processing, it is put into sealing pressure resistance
Supercritical extract container, is added solvent, and solvent quality is 2 times of quality of material.At 35 DEG C, 10MPa(is more than the stagnation temperature of solvent
Degree and critical pressure) under conditions of, material is stirred and is mixed with solvent, material is allowed to come into full contact with solvent.It is quiet later
Precipitating is set, solvent is leached, then under room temperature at 25 DEG C, reduces pressure to normal pressure (0.1MPa), allows solvent to volatilize, stay
18kg liquid is substance seeds of rubber tree fatty contents of the invention.
Disturbances in patients with Parkinson disease penta, female, the age 62 years old, patient main suit are as follows: " I has found that the right hand (or left hand) of oneself must not recently
Strength, it is agile in the past to be not so good as, and writes unlike so beautiful in the past, and the harvest for beating egg thinks that the right hand is not obedient, not as good as another
Hand is flexible.Think that right leg hair is heavy when on foot, it appears that it is a little dilatory, it sleeps also not so good, it is usually more irritated." levodopa
The pharmaceutical admixtures of preparation are treated, and after treatment one month, dose is kept to original half, and are started edible the present embodiment and be made
Seeds of rubber tree fatty contents, amount is 30g/ day (to be directed to the substance that is assisted in the treatment of of disturbances in patients with Parkinson disease
Meter), after four months (behind 3 months of morbidity treatment), conditions of patients can remain stable, and cardinal symptom and sign take a favorable turn.It says
It is bright to eat substance seeds of rubber tree fatty contents of the invention, there is good adjuvant treatment effect to Parkinson's disease patients.
Embodiment 6
Seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5, by the part and excipient weight
Excipient, pelletizing press sheet is added in ratio than 1:1 or 1:2.Tablet can be used as drug, health food or food.
Embodiment 7
Seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5 and are wrapped in soft capsule by the part
In capsule material, routinely soft capsule is made in capsule preparations method.Soft capsule can be used as drug, health food or food.
Embodiment 8
Seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5, with the part, in addition emulsifier,
Osmotic pressure regulator and water obtain emulsion for injection by high-pressure homogeneous emulsification.
Embodiment 9
Seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5, by the part, then as follows
Tablet is made:
Tablet: seeds of rubber tree fatty contents 100mg
Appropriate starch
Appropriate corn pulp
Magnesium Stearate proper quantity
Preparation method: seeds of rubber tree fatty contents are mixed with auxiliary agent, and sieving uniformly mixes in suitable container,
Obtained granulating mixture tabletting.
Embodiment 10
Seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5, by the part, then as follows
Soft capsule is made:
Soft capsule: seeds of rubber tree fatty contents 1000mg
Appropriate gelatin
Appropriate glycerol
Appropriate amount of water
Preparation method: gelatin, glycerol, which are put into distilled water, to impregnate makes gelatin expansion, softening, is then uniformly mixed, obtains
Capsule material glue.Prepared capsule material glue is taken out, is coated in flat plate surface, keeps thickness uniform, then with 90 DEG C or so
Temperature heating, evaporates surface moisture, becomes the cushion compound for having certain toughness, having certain elasticity.Finally with pelleting mold or
Automatic rotation rolling capsule machine, seeds of rubber tree fatty contents (1000mg) are fitted into soft capsule skin, soft capsule is produced.
Embodiment 11
Seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5, by the part, then as follows
Emulsion for injection is made:
Emulsion for injection: seeds of rubber tree fatty contents 200g
Appropriate lecithin
Appropriate glycerol
Appropriate sodium chloride
Appropriate amount of water
Preparation method: according to formula, by seeds of rubber tree fatty contents, lecithin, glycerol mixing adds water to 1000mL, adds
Appropriate sodium chloride adjusts osmotic pressure, high-pressure homogeneous emulsification, and 121 DEG C of sterilizings are down to room temperature to get emulsion for injection is arrived.
Embodiment 12
Tablet: being made seeds of rubber tree fatty contents 10mg, lactose 180mg of the invention by the method in embodiment 2-5,
Starch 55mg, magnesium stearate 5mg；
Preparation method: seeds of rubber tree fatty contents of the invention, newborn sugar and starch will be made by the method in embodiment 2-5
Mixing, is uniformly moistened with water, and the mixture after moistening is sieved and is dried, re-sieving, magnesium stearate is added, then by mixture
Tabletting, every slice weight 250mg, seeds of rubber tree fatty contents content of the invention are 10mg.
Embodiment 13
Capsule: seeds of rubber tree fatty contents 2000g of the invention, gelatin is made by the method in embodiment 2-5
1000g, glycerol 500g, water 1000g；
Preparation method: by gelatin 1000g, glycerol 500g, being put into 1000g water to impregnate makes gelatin expansion, softening, and then stirring is mixed
It closes uniformly, obtains capsule material glue.Prepared capsule material glue is taken out, is coated in flat plate surface, keeps thickness uniform, then uses
90 DEG C or so of temperature heating, evaporates surface moisture, becomes the cushion compound for having certain toughness, having certain elasticity.Finally with pressure
Ball mold rotates rolling capsule machine automatically, and seeds of rubber tree fatty contents 1000mg is fitted into soft capsule skin, and flexible glue is made
Capsule.Every soft capsule weight 1.4g, seeds of rubber tree fatty contents content of the invention is 1000mg.
Embodiment 14
Emulsion for injection: being made seeds of rubber tree fatty contents 200g, glycerol 25g of the invention by the method in embodiment 2-5,
Lecithin 12g, water 1000g, sodium chloride 1g,.
Preparation method: seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5 in accurate weighing
200g, glycerol 25g, lecithin 12g, mixing add water to 1000mL, add sodium chloride, osmotic pressure is adjusted to 350mosm/kg
H2O.High-pressure homogeneous emulsification obtains emulsion, and 121 DEG C of sterilizings are down to room temperature, are aseptically filled to the sterile glass of 250mL
It is encapsulated in glass bottle.Every bottle of emulsion for injection specification is 250mL, and seeds of rubber tree fatty contents content of the invention is 50g.
Embodiment 15
Food: being made seeds of rubber tree fatty contents of the invention by the method in embodiment 2-5, by the part and common food
It is reconciled with oil, is directly becoming food (edible oil).
Preparation method: seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5 in 10kg, addition
Into 10kg soybean oil, 20kg blending edible oil is obtained.By the filling vial at 500g of blending edible oil, rubber of the invention
The sub- fatty contents content of tree species is 250g.
Claims (11)
1. seeds of rubber tree fatty contents, it is characterised in that the seeds of rubber tree fatty contents are by any in following methods
Kind is prepared:
Mechanical presses method: using virgin rubber tree species as raw material, after drying shelling, kernel is obtained, kernel material is before extrusion
It is heated to 80-100 DEG C, then by static squeeze or dynamic screw extrusion, extrusion liquid is rubber tree
Seed fatty contents；
Extraction method: using virgin rubber tree species as raw material, after drying shelling, obtaining kernel, and kernel is carried out extruding, is granulated
Or it is rolling embryo with leaching container that is after processing, being put into sealing, solvent is added, selected solvent is soybean extracting solvent no.6, boiling
One of 30-90 DEG C of point range of petroleum ether, n-hexane, ether, ethyl acetate, n-butanol, or wherein several mixing
Object is stirred and mixes with solvent to material under the temperature condition and normal pressure lower than solvent boiling point, or carries out ultrasonic wave
Processing, allows material to come into full contact with solvent, staticly settles later, leaches solvent, then in the temperature for being higher than solvent boiling point and very
Under empty condition, solvent is allowed to volatilize, the liquid stayed is seeds of rubber tree fatty contents；
Supercritical extract: using virgin rubber tree species as raw material, after drying shelling, obtaining kernel, and kernel is carried out extruding, is granulated
Or after rolling embryo processing, it is put into the supercritical extract container of sealing pressure resistance, solvents carbon dioxide is added, is being more than solvent critical
Under conditions of temperature and critical pressure, material is stirred and is mixed with solvent, or carry out ultrasonication, allow material and
Solvent comes into full contact with.
2. staticly settling later, solvent is leached, then at room temperature, reduces pressure, allows solvent to volatilize, the liquid stayed
Substance is seeds of rubber tree fatty contents.
3. seeds of rubber tree fatty contents described in claim 1 and pharmaceutically acceptable carrier containing therapeutically effective amount
Pharmaceutical composition.
4. health food is made of seeds of rubber tree fatty contents described in claim 1 and health food common carrier.
5. food is made of seeds of rubber tree fatty contents described in claim 1 and food common carrier.
6. seeds of rubber tree fatty contents described in claim 1 are in preparation treatment or the drug of adjuvant treatment parkinsonism disease
In application.
7. application as claimed in claim 5, which is characterized in that the seeds of rubber tree fatty contents are as in drug
Sole active agent.
8. seeds of rubber tree fatty contents described in claim 1 are in preparation treatment or the health care food of adjuvant treatment parkinsonism
Application in product.
9. application as claimed in claim 7, which is characterized in that the seeds of rubber tree fatty contents are as unique living
Property ingredient.
10. seeds of rubber tree fatty contents described in claim 1 answering in the food of preparation adjuvant treatment parkinsonism
With.
11. application as claimed in claim 9, which is characterized in that the seeds of rubber tree fatty contents are as unique
Active constituent.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711140844.6A CN109793807A (en) | 2017-11-16 | 2017-11-16 | A kind of substance and preparation method and purposes for preventing and treating parkinsonism |
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| CN201711140844.6A CN109793807A (en) | 2017-11-16 | 2017-11-16 | A kind of substance and preparation method and purposes for preventing and treating parkinsonism |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101020858A (en) * | 2007-03-15 | 2007-08-22 | 中兴能源技术（武汉）有限公司 | Rubber seed oil extracting process |
| CN101475872A (en) * | 2009-01-12 | 2009-07-08 | 云南三环生物技术有限公司 | Method for extracting oil from rubber seed |
| CN102586000A (en) * | 2012-02-10 | 2012-07-18 | 云南省热带作物科学研究所 | Preparation method of edible rubber seed oil |
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2017
- 2017-11-16 CN CN201711140844.6A patent/CN109793807A/en not_active Withdrawn
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|---|---|---|---|---|
| CN101020858A (en) * | 2007-03-15 | 2007-08-22 | 中兴能源技术（武汉）有限公司 | Rubber seed oil extracting process |
| CN101475872A (en) * | 2009-01-12 | 2009-07-08 | 云南三环生物技术有限公司 | Method for extracting oil from rubber seed |
| CN102586000A (en) * | 2012-02-10 | 2012-07-18 | 云南省热带作物科学研究所 | Preparation method of edible rubber seed oil |
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| 柴岩，等: "《中国特色作物产业发展研究》", 31 August 2008, 西北农林科技大学出版社 * |
| 王慧敏: "橡胶籽油的提取、精炼及其氧化稳定性研究", 《中国优秀硕士学位论文全文数据库工程科技Ι辑》 * |
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Application publication date: 20190524 |