CN109793775A - It is a kind of for preventing and treating the substance and purposes of hyperlipidemia - Google Patents
It is a kind of for preventing and treating the substance and purposes of hyperlipidemia Download PDFInfo
- Publication number
- CN109793775A CN109793775A CN201711136369.5A CN201711136369A CN109793775A CN 109793775 A CN109793775 A CN 109793775A CN 201711136369 A CN201711136369 A CN 201711136369A CN 109793775 A CN109793775 A CN 109793775A
- Authority
- CN
- China
- Prior art keywords
- rubber tree
- seeds
- solvent
- fatty contents
- tree fatty
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a kind of seeds of rubber tree fatty contents and application thereof.Substance of the invention is the fatty contents of seeds of rubber tree, be can be applied in drug, health food and food, for preventing and treating hyperlipidemia.The substance is made with the kernel for drying the seeds of rubber tree after decladding by the methods of mechanical presses method, extraction method, supercritical extraction.Hyperlipemia passes through daily to be taken or the edible drug, health food, food for being added to the substance can be obtained good treatment and adjuvant treatment effect.
Description
Technical field
The invention belongs to biomedicine fields, and specifically the present invention relates to a kind of for preventing and treating the object of hyperlipidemia
Matter (seeds of rubber tree fatty contents) and purposes.
Background technique
In recent years, the incidence of hyperlipidemia is in obvious ascendant trend, age of onset is also shifted to an earlier date, to human health
Very harmful, this trend is mainly with people's social progress, the continuous improvement of living standard, the eating habit of people
Change gradually occurs, by plenty of meat and fish, the gluttony crapulence of original plain tea and simple food till now, present many people is caused to be suffering from
Vascular hypertension.
Hyperlipidemia refers to blood cholesterol (TC) or triglycerides (TG) is excessively high or high-density lipoprotein cholesterol (HLD-C)
Too low, modern medicine is referred to as dyslipidemia.If hyperlipemia, it is be easy to cause " blood is thick ", is deposited on vascular wall, is gradually blocked up
Blood vessel is filled in, keeps blood flow slack-off, serious blood flow interrupts.
For the current drug for clinically being used to treat hyperlipidemia mainly based on Statins, drug effect is significant but has side effect.
Therefore, exploitation can be used to prevent and treat hyperlipidemia, and the substance of not no toxic side effect is of crucial importance.
Summary of the invention
Substance (the fat-soluble portion of seeds of rubber tree that the purpose of the present invention is to provide a kind of for preventing and treating hyperlipidemia
Point) and purposes.The substance is the fatty contents of the seed of rubber tree, can be applied to drug, health food, in food, uses
In prevention and treatment hyperlipidemia.Hyperlipemic patients pass through daily take or the edible drug for being added to the substance, health food,
Food can be obtained good treatment and adjuvant treatment effect.
In order to realize above-mentioned purpose of the invention, the present invention provides the following technical solutions:
Seeds of rubber tree fatty contents, the seeds of rubber tree fatty contents are prepared by any one of following methods:
Mechanical presses method: using virgin rubber tree species as raw material, after drying shelling, kernel is obtained, kernel material is before extrusion
It is heated to 80-100 DEG C, then by static squeeze or dynamic screw extrusion, extrusion liquid is rubber tree
Seed fatty contents；
Extraction method: using virgin rubber tree species as raw material, after drying shelling, obtaining kernel, and kernel is carried out extruding, is granulated
Or it is rolling embryo with leaching container that is after processing, being put into sealing, solvent is added, selected solvent is soybean extracting solvent no.6, boiling
One of 30-90 DEG C of point range of petroleum ether, n-hexane, ether, ethyl acetate, n-butanol, or wherein several mixing
Object is stirred and mixes with solvent to material under the temperature condition and normal pressure lower than solvent boiling point, or carries out ultrasonic wave
Processing, allows material to come into full contact with solvent, staticly settles later, leaches solvent, then in the temperature for being higher than solvent boiling point and very
Under empty condition, solvent is allowed to volatilize, the liquid stayed is seeds of rubber tree fatty contents；
Supercritical extract: using virgin rubber tree species as raw material, after drying shelling, obtaining kernel, and kernel is carried out extruding, is granulated
Or after rolling embryo processing, it is put into the supercritical extract container of sealing pressure resistance, solvents carbon dioxide is added, is being more than solvent critical
Under conditions of temperature and critical pressure, material is stirred and is mixed with solvent, or carry out ultrasonication, allow material and
Solvent comes into full contact with.It staticly settles later, leaches solvent, then at room temperature, reduce pressure, allow solvent to volatilize, leave
The liquid come is seeds of rubber tree fatty contents.
Invention also provides the seeds of rubber tree fatty contents containing therapeutically effective amount and pharmaceutically may be used
The pharmaceutical composition of the carrier of receiving.
And health food, it is made of the seeds of rubber tree fatty contents and health food common carrier.
With food is made of the seeds of rubber tree fatty contents and food common carrier.
The present invention also provides the seeds of rubber tree fatty contents in preparing the drug for treating hyperlipidemia
Using.
Application as mentioned, wherein the seeds of rubber tree fatty contents are as sole active agent.
Present invention further provides the seeds of rubber tree fatty contents in preparation for preventing and assisting in the treatment of
Application in the health food of hyperlipidemia.
And the seeds of rubber tree fatty contents are in preparing the food for preventing and assisting in the treatment of hyperlipidemia
Application.
Application as mentioned, wherein the seeds of rubber tree fatty contents are as sole active agent.
Shown with existing according to animal model experiment data and other clinical laboratory datas for hyperlipemic patients
It is treated compared with the drug of adjuvant treatment, the present invention has the advantage that the treatment that (1) is hyperlipidemia is mentioned with adjuvant treatment
A kind of completely new substance is supplied；(2) without side-effects, it can be used for a long time for hyperlipemic patients；(3) hyperlipidemia effect is prevented and treated
Fruit is significant, the experimental results showed that substance of the present invention can significantly reduce cholesterol (TC) in mice serum, triglycerides (TG) and
Low density lipoprotein cholesterol (LDL-C) is horizontal, hence it is evident that increasing high density lipoprotein cholesterol (HLD-C) is horizontal.
Specific embodiment
Below by the embodiment of the present invention, property content is described further for the essence of the present invention, but is not limited with this
The fixed present invention.
Embodiment 1
This example is the influence for proving substance of the present invention to mice serum blood lipid level.Before giving tested material, with material modeling high in fat.
Give reference material after the completion of modeling and object of the present invention tested, after experiment, CHO, TG in measurement mice serum, HDL-C,
LDL-C content.Specific experiment method and steps are as follows.
1 experimental animal
The healthy adult cleaning grade BALB/c male mice for selecting Beijing Vital River Experimental Animals Technology Co., Ltd. to provide is (perhaps
It is SCXK (capital) 2012-0001 that number, which can be demonstrate,proved), mouse weight range is 20.0 ± 2.0g.
2 experimental designs
BALB/c male mice adaptive feeding is after 1 week, according to mouse weight, 45 mouse is randomly divided into 3 groups, are respectively as follows:
High dose substance control group, substance low dose group of the present invention and substance high dose group of the present invention, every group 15.Each group mouse is given
In material high in fat, high lipid food formula are as follows: lard 18%, sucrose 10%, cholesterol 0.9%, remaining is basal feed.
The selection of 3 dosage gives mode with tested material:
Continuous gavage gives tested material after mouse adapts to one week of raising.Tested material human body recommended amounts are 15.0g/ days, by adult
60kg batheroom scale, being equivalent to daily per kilogram of body weight recommended amounts is 250.0mg.High and low dose group mouse is given respectively
The tested material of 7500.0mg/kg.BW and 2500.0mg/kg.BW, 30,10 multiple doses of the suitable human body recommended amounts of difference, each dosage
Group gives substance of the present invention, and high dose substance control group gives olive oil.After continuous gavage 30 days, plucks eyeball and take blood (before blood sampling
Fasting 12h, can't help water), 3000r/min is centrifuged 15min and separates serum, illustrates to require in measurement mice serum according to kit
CHO, TG, HDL-C, LDL-C content.
4 test methods
Each group mouse is fed by experimental design, mouse is freely eaten and drinking-water, and 20-25 DEG C of raising temperature, humidity 40%-
45%.The stomach-filling of every morning 9:00 stomach-filling the 30th day, is plucked eyeball and is taken blood (fasting 12h, can't help water before taking a blood sample), 3000r/min from
Heart 15min separates serum, illustrates to require CHO, TG, HDL-C, LDL-C content in measurement mice serum according to kit.
5 data processings and result judgement
Experimental data input computer establishes database with EXCEL software, for statistical analysis using SPSS19.0 software.If
Each group variance is neat, using one-way analysis of variance method (oneway-ANOVA), using α=0.05 as significance, calculates F value,
If F < F0.05, conclusion each group no significant difference is obtained；If F >=F0.05, P≤0.05 is then compareed with multiple experimental groups and one
The comparative approach two-by-two of mean is counted between group.If not being able to satisfy homogeneity of variance, multiple ratio is carried out using Duncan ' s method
Compared with.Experimental result with " mean+SD ((± SD) " it indicates.
6 results and analysis
The substance of the present invention of table 1 to mice serum blood lipid level influence (± SD)
| Grouping | Number of animals (only) | TC | TG | HDL-C | LDL-C |
| High dose substance control group | 15 | 3.22±0.37A | 1.11±0.21A | 1.68±0.13A | 0.56±0.16A |
| Substance low dose group of the present invention | 15 | 2.69±0.46B | 0.76±0.26B | 1.93±0.36B | 0.47±0.12A |
| Substance high dose group of the present invention | 15 | 2.26±0.13C | 0.71±0.20B | 2.32±0.24C | 0.28±0.04B |
Note: significant (P < 0.05) with column data difference lowercase letter indication difference in table；Different capitalizations indicate that difference is extremely aobvious
It writes (P < 0.01);Same letter indicates that difference is not significant (P > 0.05).
The experimental results showed that dosages of substance group of the present invention is compared with hyperlipidemia model control group, serum after intragastric administration on mice 30d
CHO, TG content reduce, and difference is extremely significant (P < 0.01)；Substance low dose group of the present invention is compared with high dose control group, blood
Clear LDL-C difference is not significant (P > 0.05), but its content reduces, and substance high dose group of the present invention is compareed with high dose substance
Group is compared, and difference is extremely significant (P < 0.01)；Dosages of substance group of the present invention is compared with hyperlipidemia model control group, serum HDL-C level
It increases, and difference is extremely significant (P < 0.01).
Embodiment 2
Mechanical presses method prepares seeds of rubber tree fatty contents, and institute's choosing method is static extrusion.With 100kg virgin rubber tree
Seed is raw material, after drying shelling, prepares kernel 40kg.Kernel material arrives 80-100 DEG C in heat, then squeezes by static
Pressure, pressure 50MPa, squeezing out 12kg liquid is substance seeds of rubber tree fatty contents of the invention.
16 patients that this effect example randomly selects physical examination too high cholesterol within the hospital participate in verifying, by 16 volunteers
Be randomly divided into two groups, every group of 8 people, wherein one group to eat substance seeds of rubber tree grease of the invention before the meal in the morning, afternoon and evening daily molten
Property, amount is 15.0g/ days, and eating method is taken before the meal for daily three.Another set is edible fat-soluble made of olive oil
Substance, amount and eating method are identical as substance of the present invention.Observe 2 months cholesterol datas, and prepare table such as the following table 2,
Table 3:(unit: mmol/L)
2 olive oil data of table
| Volunteer's number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
| Former cholesterol data | 7.34 | 8.45 | 6.55 | 9.16 | 10.27 | 9.19 | 12.32 | 6.64 |
| After one month | 7.21 | 7.97 | 6.43 | 8.91 | 9.71 | 8.82 | 11.51 | 6.33 |
| After two months | 7.12 | 7.09 | 6.13 | 8.72 | 9.43 | 8.51 | 11.01 | 6.34 |
The substance data of the present invention of table 3
| Volunteer's number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
| Former cholesterol data | 8.42 | 7.27 | 8.51 | 8.12 | 9.17 | 12.21 | 13.12 | 7.34 |
| After one month | 6.61 | 5.39 | 6.13 | 6.56 | 7.21 | 10.33 | 10.71 | 5.21 |
| After two months | 4.82 | 4.17 | 5.01 | 5.12 | 5.53 | 6.81 | 7.01 | 4.11 |
The experimental results showed that substance of the present invention is for reducing, body's cholesterol is higher positive effect.
Embodiment 3
Mechanical presses method prepares seeds of rubber tree fatty contents, and institute's choosing method is screw extrusion method.With 100kg virgin rubber tree
Seed is raw material, after drying shelling, prepares kernel 40kg.Kernel material arrives 80-100 DEG C in heat, then passes through dynamic spiral shell
Rotation squeezes, and the screw extrusion time is 45 seconds or so, and squeezing out 15kg liquid is substance seeds of rubber tree liposoluble of the invention
Property part.
This effect example has auxiliary reducing blood lipid performance to verify the present invention to human body, and the present inventor organizes 100 aspirations
Person tests.The selection criteria of volunteer is in the blood lipid water in normal diet, after detection fasting 12-14 hours
Flat, at least lipids detection twice in half a year, serum total cholesterol is in 5.18-6.21mmol/L, and serum triglyceride exists
1.70-2.25mmol/L.Wherein 50 volunteers are 20.0g/ days by amount, and eating method takes this hair for daily three before the meal
Bright substance seeds of rubber tree grease insoluble portion, in addition 50 volunteers take placebo as control.Given the test agent is given
Time 45 days.Control group and the primary work of test-meal group, diet are constant during experiment.The measurement serum of volunteer is tested after test
TC, TG, LDL-C, HDL-C are horizontal, reduce > 15%, HDL-C rising > 0.104mmol/L as TC reduces > 10%, TG, then determine have
Have that auxiliary lipid-lowering efficacy is effective, effective standard is such as not achieved, then judgement is invalid.
Pass through the test of volunteer: 50 are taken volunteers sera TC, TG, LDL-C horizontal checkout front and back of placebo
Without significant change；49 reach effective standard, total effective rate 98% in 50 volunteers for taking substance of the present invention.In addition, institute
Have during the test of volunteer and after the test in 6 months, does not occur the influence to human body health.
Embodiment 4
Solvent extraction prepares seeds of rubber tree fatty contents, and extracting selected solvent is No. 6 solvents.With the fresh rubber of 100kg
Gum seed is that raw material prepares kernel 40kg after drying shelling.Then after kernel being carried out expanding treatment, it is put into sealing
Leaching container, the solvent of 2 times of weight is added.Under 55 DEG C of (be lower than solvent boiling point) conditions and normal pressure, to material and solvent into
Row is stirred and is mixed, and material is allowed to come into full contact with solvent.It staticly settles later, leaches solvent, then (be higher than solvent at 120 DEG C
Boiling temperature) under 100Pa vacuum condition, allow solvent to volatilize, staying 18kg liquid is substance rubber of the invention
The sub- fatty contents of tree species.
This effect example is 100 hyperlipemic patients of tracking, continuously eats liposoluble substance provided by the invention three months,
Middle amount is 25.0g/ days, and eating method takes substance seeds of rubber tree grease dissolubility portion of the invention for daily three before the meal
Point, start one month, do not reduce conventional reducing blood lipid dosage, stringent smoking cessation is relieved the effect of alcohol, and from second month, starts to gradually decrease often
Reducing blood lipid dosage is advised, to third month, hypolipidemic is drunk in stopping, and holding eats fat-soluble object provided by the invention daily
Matter after 100 days, measures blood lipid on an empty stomach, as a result see the table below:
| Total plasma cholesterol (mmol/L) | <5.2 | <5.8 | <6.0 |
| Plasma triglyceride (mmol/L) | <1.7 | <2.0 | <2.3 |
| Number | 70 | 25 | 5 |
| Conclusion | Normally | Normally | It is normal reluctantly |
It as can be seen from the table, can after eating liposoluble substance provided by the invention for 100 hyperlipemic patients of detection
The number of blood lipid is effectively reduced as 95 people, wherein other 5 people due to older, also belongs to normal lipid, therefore hyperlipidemia is suffered from
Person, which can trust, eats liposoluble substance provided by the invention.
Embodiment 5
Supercritical extraction prepares seeds of rubber tree fatty contents, and selected solvent is carbon dioxide.With 100kg virgin rubber
Tree species is that raw material prepares kernel 40kg after drying shelling.After kernel is carried out granulation processing, it is put into sealing pressure resistance
Supercritical extract container, is added solvent, and solvent quality is 2 times of quality of material.At 35 DEG C, 10MPa(is more than the stagnation temperature of solvent
Degree and critical pressure) under conditions of, material is stirred and is mixed with solvent, material is allowed to come into full contact with solvent.It is quiet later
Precipitating is set, solvent is leached, then under room temperature at 25 DEG C, reduces pressure to normal pressure (0.1MPa), allows solvent to volatilize, stay
18kg liquid is substance seeds of rubber tree fatty contents of the invention.
Mr. Lin, male, 45 years old, had a surplus with hyperlipidemia 2 years, often felt dizzy uncomfortable in chest, nervous palpitaition, limbs fatigue, limb
It is fat-soluble to eat the present invention by the symptoms such as body numbness, triglyceride 2.89, high-density lipoprotein cholesterol HDL-C 2.06mol/L
After 6 months, symptom out of strength, uncomfortable in chest disappears substance (wherein amount is 30.0g/ days, and eating method is taken before the meal for daily three),
Triglycerides is reduced to normal value after 08 months 1 year edible, and high-density lipoprotein cholesterol is reduced to just after eating 06 months 1 year
Constant value.
Embodiment 6:
Seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5, by the part and excipient weight
Excipient, pelletizing press sheet is added in ratio than 1:1 or 1:2.Tablet can be used as drug, health food or food.
Embodiment 7:
Seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5 and are wrapped in soft capsule by the part
In capsule material, routinely soft capsule is made in capsule preparations method.Soft capsule can be used as drug, health food or food.
Embodiment 8:
Seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5, with the part, in addition emulsifier,
Osmotic pressure regulator and water obtain emulsion for injection by high-pressure homogeneous emulsification.
Embodiment 9
Seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5, by the part, then as follows
Tablet is made:
Tablet: seeds of rubber tree fatty contents 100mg
Appropriate starch
Appropriate corn pulp
Magnesium Stearate proper quantity
Preparation method: seeds of rubber tree fatty contents are mixed with auxiliary agent, and sieving uniformly mixes in suitable container,
Obtained granulating mixture tabletting.
Embodiment 10
Seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5, by the part, then as follows
Soft capsule is made:
Soft capsule: seeds of rubber tree fatty contents 1000mg
Appropriate gelatin
Appropriate glycerol
Appropriate amount of water
Preparation method: gelatin, glycerol, which are put into distilled water, to impregnate makes gelatin expansion, softening, is then uniformly mixed, obtains
Capsule material glue.Prepared capsule material glue is taken out, is coated in flat plate surface, keeps thickness uniform, then with 90 DEG C or so
Temperature heating, evaporates surface moisture, becomes the cushion compound for having certain toughness, having certain elasticity.Finally with pelleting mold or
Automatic rotation rolling capsule machine, seeds of rubber tree fatty contents (1000mg) are fitted into soft capsule skin, soft capsule is produced.
Seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5, by the part, then by following
Emulsion for injection is made in method:
Emulsion for injection: seeds of rubber tree fatty contents 200g
Appropriate lecithin
Appropriate glycerol
Appropriate sodium chloride
Appropriate amount of water
Preparation method: according to formula, by seeds of rubber tree fatty contents, lecithin, glycerol mixing adds water to 1000mL, adds
Appropriate sodium chloride adjusts osmotic pressure, high-pressure homogeneous emulsification, and 121 DEG C of sterilizings are down to room temperature to get emulsion for injection is arrived.
Embodiment 12
Tablet: being made seeds of rubber tree fatty contents 100mg, lactose 180mg of the invention by the method in embodiment 2-5,
Starch 55mg, magnesium stearate 5mg；
Preparation method: seeds of rubber tree fatty contents of the invention, newborn sugar and starch will be made by the method in embodiment 2-5
Mixing, is uniformly moistened with water, and the mixture after moistening is sieved and is dried, re-sieving, magnesium stearate is added, then by mixture
Tabletting, every slice weight 250mg, seeds of rubber tree fatty contents content of the invention are 10mg.
Embodiment 13
Capsule: seeds of rubber tree fatty contents 2000g of the invention, gelatin is made by the method in embodiment 2-5
1000g, glycerol 500g, water 1000g；
Preparation method: by gelatin 1000g, glycerol 500g, being put into 1000g water to impregnate makes gelatin expansion, softening, and then stirring is mixed
It closes uniformly, obtains capsule material glue.Prepared capsule material glue is taken out, is coated in flat plate surface, keeps thickness uniform, then uses
90 DEG C or so of temperature heating, evaporates surface moisture, becomes the cushion compound for having certain toughness, having certain elasticity.Finally with pressure
Ball mold rotates rolling capsule machine automatically, and seeds of rubber tree fatty contents 1000mg is fitted into soft capsule skin, and flexible glue is made
Capsule.Every soft capsule weight 1.4g, seeds of rubber tree fatty contents content of the invention is 1000mg.
Embodiment 14
Emulsion for injection: being made seeds of rubber tree fatty contents 200g, glycerol 25g of the invention by the method in embodiment 2-5,
Lecithin 12g, water 1000g, sodium chloride 1g.
Preparation method: accurate weighing by the method in embodiment 2-5 be made seeds of rubber tree fatty contents 200g of the invention,
Glycerol 25g, lecithin 12g, mixing add water to 1000mL, add sodium chloride, osmotic pressure is adjusted to 350mosm/kg H2O。
High-pressure homogeneous emulsification obtains emulsion, and 121 DEG C of sterilizings are down to room temperature, are aseptically filled to the sterile glass vials of 250mL
Middle encapsulation.Every bottle of emulsion for injection specification is 250mL, and seeds of rubber tree fatty contents content of the invention is 50g.
Embodiment 15
Food: being made seeds of rubber tree fatty contents of the invention by the method in embodiment 2-5, by the part and common food
It is reconciled with oil, is directly becoming food (edible oil)
Preparation method: seeds of rubber tree fatty contents of the invention are made by the method in embodiment 2-5 in 10kg, are added to
In 10kg soybean oil, 20kg blending edible oil is obtained.By the filling vial at 500g of blending edible oil, rubber tree of the invention
Seed fatty contents content is 250g.
Claims (10)
1. seeds of rubber tree fatty contents, it is characterised in that the seeds of rubber tree fatty contents are by any in following methods
Kind is prepared:
Mechanical presses method: using virgin rubber tree species as raw material, after drying shelling, kernel is obtained, kernel material is before extrusion
It is heated to 80-100 DEG C, then by static squeeze or dynamic screw extrusion, extrusion liquid is rubber tree
Seed fatty contents；
Extraction method: using virgin rubber tree species as raw material, after drying shelling, obtaining kernel, and kernel is carried out extruding, is granulated
Or it is rolling embryo with leaching container that is after processing, being put into sealing, solvent is added, selected solvent is soybean extracting solvent no.6, boiling
One of 30-90 DEG C of point range of petroleum ether, n-hexane, ether, ethyl acetate, n-butanol, or wherein several mixing
Object is stirred and mixes with solvent to material under the temperature condition and normal pressure lower than solvent boiling point, or carries out ultrasonic wave
Processing, allows material to come into full contact with solvent, staticly settles later, leaches solvent, then in the temperature for being higher than solvent boiling point and very
Under empty condition, solvent is allowed to volatilize, the liquid stayed is seeds of rubber tree fatty contents；
Supercritical extract: using virgin rubber tree species as raw material, after drying shelling, obtaining kernel, and kernel is carried out extruding, is granulated
Or after rolling embryo processing, it is put into the supercritical extract container of sealing pressure resistance, solvents carbon dioxide is added, is being more than solvent critical
Under conditions of temperature and critical pressure, material is stirred and is mixed with solvent, or carry out ultrasonication, allow material and
Solvent comes into full contact with, and staticly settles later, leaches solvent, then at room temperature, reduces pressure, allows solvent to volatilize, leave
The liquid come is seeds of rubber tree fatty contents.
2. seeds of rubber tree fatty contents described in claim 1 and pharmaceutically acceptable carrier containing therapeutically effective amount
Pharmaceutical composition.
3. health food is made of seeds of rubber tree fatty contents described in claim 1 and health food common carrier.
4. food is made of seeds of rubber tree fatty contents described in claim 1 and food common carrier.
5. seeds of rubber tree fatty contents described in claim 1 prevent and treat the application in high blood cholesterol drug in preparation.
6. application as claimed in claim 5, which is characterized in that the seeds of rubber tree fatty contents are as in drug
Sole active agent.
7. seeds of rubber tree fatty contents described in claim 1 are in the health food of preparation prevention and adjuvant treatment hyperlipidemia
In application.
8. application as claimed in claim 7, which is characterized in that the seeds of rubber tree fatty contents are as unique living
Property ingredient.
9. seeds of rubber tree fatty contents described in claim 1 are in the food of preparation prevention and adjuvant treatment hyperlipidemia
Using.
10. application as claimed in claim 9, which is characterized in that the seeds of rubber tree fatty contents are as unique
Active constituent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711136369.5A CN109793775A (en) | 2017-11-16 | 2017-11-16 | It is a kind of for preventing and treating the substance and purposes of hyperlipidemia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711136369.5A CN109793775A (en) | 2017-11-16 | 2017-11-16 | It is a kind of for preventing and treating the substance and purposes of hyperlipidemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109793775A true CN109793775A (en) | 2019-05-24 |
Family
ID=66555378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711136369.5A Pending CN109793775A (en) | 2017-11-16 | 2017-11-16 | It is a kind of for preventing and treating the substance and purposes of hyperlipidemia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109793775A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1154217A (en) * | 1996-12-11 | 1997-07-16 | 曹敏 | Method for making edible health-care kernel and edible oil from seed of rubber tree |
| CN101288358A (en) * | 2007-04-16 | 2008-10-22 | 中国热带农业科学院热带生物技术研究所 | Rubber seed storage technique |
| CN101475872A (en) * | 2009-01-12 | 2009-07-08 | 云南三环生物技术有限公司 | Method for extracting oil from rubber seed |
-
2017
- 2017-11-16 CN CN201711136369.5A patent/CN109793775A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1154217A (en) * | 1996-12-11 | 1997-07-16 | 曹敏 | Method for making edible health-care kernel and edible oil from seed of rubber tree |
| CN101288358A (en) * | 2007-04-16 | 2008-10-22 | 中国热带农业科学院热带生物技术研究所 | Rubber seed storage technique |
| CN101475872A (en) * | 2009-01-12 | 2009-07-08 | 云南三环生物技术有限公司 | Method for extracting oil from rubber seed |
Non-Patent Citations (1)
| Title |
|---|
| 王慧敏: "橡胶籽油的提取、精炼及其氧化稳定性研究", 《中国优秀硕士学论文全文数据库工程科技Ι辑》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105169203B (en) | A kind of Fructus Amomi extract and application thereof | |
| CN109793775A (en) | It is a kind of for preventing and treating the substance and purposes of hyperlipidemia | |
| CN103920140B (en) | A kind of people is with blood sugar lowering Weight-reducing and lipid-lowering compound preparation | |
| CN110960502A (en) | Substance for treating metabolic syndrome and application thereof | |
| CN109793809A (en) | A kind of substance and preparation method and purposes for preventing and treating hyperlipemia | |
| CN109793784A (en) | A kind of substance and preparation method and purposes for preventing and treating hyperlipemia | |
| CN108635373A (en) | The new application of donkey-hide gelatin Weight-reducing and lipid-lowering | |
| CN105641674A (en) | Compound nanometer preparation for treating diabetes mellitus type 2 and preparation method thereof | |
| CN109793780A (en) | It is a kind of for the hypoglycemic substance of type II diabetes, preparation method and applications | |
| CN110302340A (en) | A kind of Chinese medicinal tablet and preparation method thereof with hypolipemic function | |
| CN109793808A (en) | It is a kind of for preventing and treating the substance and purposes of parkinsonism | |
| CN109793807A (en) | A kind of substance and preparation method and purposes for preventing and treating parkinsonism | |
| CN110433191A (en) | A kind of substance is restoring and is improving the application in adult male sexual function | |
| CN108159258A (en) | Treatment is with Chinese medicine for treating diabetes composition of lumbar vertebra disease and preparation method thereof | |
| CN114306373B (en) | Lipid-lowering composition containing acanthopanax trifoliatus neutral polysaccharide ATP1-1 and preparation method thereof | |
| CN102846731A (en) | A Chinese medicinal composition for the treatment of breast hyperplasia or mastitis and its preparation method | |
| CN109793801A (en) | It is a kind of improve immunity substance and its application | |
| CN109793802A (en) | A kind of substance and preparation method and purposes for preventing and treating parkinsonism | |
| CN109793787A (en) | It is a kind of for the hypoglycemic substance of Gestational hyperglycemia, preparation method and applications | |
| CN108261511A (en) | A kind of composition with antiobesity action and preparation method thereof and purposes | |
| CN105770187A (en) | Health food capable of improving immunity and preparing method thereof | |
| KR101888478B1 (en) | Compostions for reducing weight using herb medicine | |
| CN109793794A (en) | A kind of substance, the preparation method and applications of alleviation and treatment gout | |
| CN109793798A (en) | A kind of substance and application for Therapy for Systemic Lupus Erythematosus and rehabilitation | |
| CN109793805A (en) | It is a kind of improve immunity substance and its application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190524 |